BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0584.0038.p (202 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_626620.1| putative transcriptional regulator [Streptomyce... 79 7e-14 ref|NP_631757.1| putative tetR-family transcriptional regulator ... 78 1e-13 ref|NP_826973.1| putative TetR-family transcriptional regulator ... 74 2e-12 gb|AAM94766.1| CalR1 [Micromonospora echinospora] 74 2e-12 ref|NP_823439.1| putative TetR-family transcriptional regulator ... 71 2e-11 >ref|NP_626620.1| putative transcriptional regulator [Streptomyces coelicolor A3(2)] emb|CAB62706.1| putative transcriptional regulator [Streptomyces coelicolor A3(2)] Length = 227 Score = 78.6 bits (192), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 62/157 (39%), Positives = 78/157 (49%), Gaps = 8/157 (5%) Query: 11 KSGLRERKKDETRRTLIEIALNLAIERGVGQVRVEDIAAAANVSLRTFNNYFPSKEAAII 70 + GLRE KK TR L+ AL L ERG + V+DIA AA+VS RTF YF SKE A Sbjct: 18 RPGLRELKKQRTRDLLLRSALELFTERGYEETTVDDIAEAADVSQRTFFRYFASKEDAAF 77 Query: 71 GNAYQRSEKIAVALADRPPGEALKDSLRAAVLAGFSE--PADRQWLA---HMILLR---D 122 A A+ RPP EA D+LR A+ +S A Q + HM R Sbjct: 78 FVARLAESHFVRAVLARPPEEAPLDALRRALAESWSTIGEAVEQLVPLELHMRFYRVIES 137 Query: 123 DPALIGAQRKAEIEFERNLAKVIAERTKKDLTRDIYP 159 PAL+ A + E E +A+V+A R D+ D P Sbjct: 138 TPALLAAHLRRATELEEEIARVVAVREGLDVDTDPRP 174 >ref|NP_631757.1| putative tetR-family transcriptional regulator [Streptomyces coelicolor A3(2)] emb|CAC22727.1| putative tetR-family transcriptional regulator [Streptomyces coelicolor A3(2)] Length = 219 Score = 78.2 bits (191), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 65/137 (47%), Positives = 81/137 (59%), Gaps = 2/137 (1%) Query: 13 GLRERKKDETRRTLIEIALNLAIERGVGQVRVEDIAAAANVSLRTFNNYFPSKEAAIIGN 72 GLRERKK TR L E AL LA+ERG QVRVEDIA AA VS RT+NNYF S+E AI+ Sbjct: 8 GLRERKKRATREALREAALRLAVERGPDQVRVEDIAEAAGVSPRTYNNYFASREQAIVSA 67 Query: 73 AY-QRSEKIAVALADRPPGEALKDSLRAAVLAGFSEPADRQWLAHMILLRDDPALIGAQR 131 R +IA A+A RP G L D++ AV+ ++ +R+ A ++L+ AL A Sbjct: 68 VTADREARIAAAVAARPAGVRLADAVTEAVVEQYTNTGEREHRA-LLLITTRTALRDAFL 126 Query: 132 KAEIEFERNLAKVIAER 148 E L VIAER Sbjct: 127 DTTAGIELPLTAVIAER 143 >ref|NP_826973.1| putative TetR-family transcriptional regulator [Streptomyces avermitilis MA-4680] dbj|BAC73508.1| putative TetR-family transcriptional regulator [Streptomyces avermitilis MA-4680] Length = 226 Score = 74.3 bits (181), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/158 (34%), Positives = 75/158 (47%), Gaps = 10/158 (6%) Query: 11 KSGLRERKKDETRRTLIEIALNLAIERGVGQVRVEDIAAAANVSLRTFNNYFPSKEAAII 70 + GLRERKK TR L+ AL L + +G + V++IA A +VS RTF YF KE A Sbjct: 6 RPGLRERKKRRTRDALLRAALELFLAQGYERTTVDEIAEAVDVSQRTFFRYFAGKEEAAF 65 Query: 71 GNAYQRSEKIAVALADRPPGEALKDSLRAAVLAGFSE---------PADRQWLAHMILLR 121 A+ +RPP EA ++LR AVL + P + + L+ Sbjct: 66 LTQRIAESHFVAAVRERPPHEAPLEALRRAVLESWETIGEAIEQVVPVELHMRTYQ-LIE 124 Query: 122 DDPALIGAQRKAEIEFERNLAKVIAERTKKDLTRDIYP 159 PAL+ + E E LA++IA R D+ D P Sbjct: 125 STPALLAVHLRHSAELEEELARIIAGREGLDVDADPRP 162 >gb|AAM94766.1| CalR1 [Micromonospora echinospora] Length = 206 Score = 73.9 bits (180), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/175 (33%), Positives = 88/175 (50%), Gaps = 4/175 (2%) Query: 26 LIEIALNLAIERGVGQVRVEDIAAAANVSLRTFNNYFPSKEAAIIGNAYQRSEKIAVALA 85 L AL L ERG+ QV VE+I+ AA VS RTF NYF K+ A++G+ + ++ LA Sbjct: 24 LTGAALRLVAERGLAQVTVEEISEAAGVSPRTFFNYFACKDDALVGDHAGDAARLVARLA 83 Query: 86 DRPPGEALKDSLRAAVLAGFSEP-ADRQ-WLAHMILLRDDPALIGAQRKAEIEFERNLAK 143 PP + +LRAA+ E +R+ W M ++ +P L+ +E ER +A+ Sbjct: 84 AVPPEVPVLTALRAALDEVIDEVRTERELWCLRMEVVTRNPVLLPRLVAGNVETERAIAE 143 Query: 144 VIAERTKKDLTRDIYPTXXXXXXXXXXXXXVFFWTSSTPGGPTLHEILDEAISQL 198 V+A R D YP + W ++ P GP L +++DEA + L Sbjct: 144 VVAARVGVDPDHG-YPALVTAVAGAAVRTAMTRW-AAHPDGPDLADLVDEAFAAL 196 >ref|NP_823439.1| putative TetR-family transcriptional regulator [Streptomyces avermitilis MA-4680] dbj|BAC69974.1| putative TetR-family transcriptional regulator [Streptomyces avermitilis MA-4680] Length = 196 Score = 70.9 bits (172), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 40/96 (41%), Positives = 56/96 (58%) Query: 7 MKTEKSGLRERKKDETRRTLIEIALNLAIERGVGQVRVEDIAAAANVSLRTFNNYFPSKE 66 M G RERKK TR+ L + AL+L +ERG QV V+DIA AA+VS T +FPSKE Sbjct: 1 MNEMTMGRRERKKAATRKALADAALDLFLERGYDQVSVKDIADAADVSTTTLFKHFPSKE 60 Query: 67 AAIIGNAYQRSEKIAVALADRPPGEALKDSLRAAVL 102 A + ++ + A+ DR PG ++ +L +L Sbjct: 61 ALVFDEDAEQEAALVSAVRDRAPGRSIPAALCEGIL 96 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.317 0.133 0.371 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 263,402,978 Number of extensions: 9068339 Number of successful extensions: 24212 Number of sequences better than 1.0e-05: 45 Number of HSP's gapped: 24221 Number of HSP's successfully gapped: 45 Length of query: 202 Length of database: 757,237,578 Length adjustment: 120 Effective length of query: 82 Effective length of database: 431,425,698 Effective search space: 35376907236 Effective search space used: 35376907236 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 123 (52.0 bits)