BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0578.0012.p (458 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_472056.1| similar to two-component sensor histidine kinas... 463 e-129 ref|NP_832968.1| Two component system histidine kinase [Bacillus... 454 e-126 ref|NP_466105.1| similar to two-component sensor histidine kinas... 454 e-126 ref|NP_845559.1| sensor histidine kinase [Bacillus anthracis str... 447 e-124 ref|NP_979572.1| sensor histidine kinase [Bacillus cereus ATCC 1... 447 e-124 >ref|NP_472056.1| similar to two-component sensor histidine kinase [Listeria innocua] pir||AI1772 two-component sensor histidine kinase homolog lin2727 [imported] - Listeria innocua (strain Clip11262) emb|CAC97953.1| lin2727 [Listeria innocua] Length = 459 Score = 463 bits (1192), Expect = e-129, Method: Compositional matrix adjust. Identities = 226/457 (49%), Positives = 313/457 (68%), Gaps = 1/457 (0%) Query: 1 MKSLYVRMSLLFCSVIVISSVLGFLISNAYYQAAIKPQNDAKLTKMAIGLQSFIE-DHPD 59 MKSLY R+ + VI+ SS+LGF +N YYQ +KP ND K K+A +Q F + + Sbjct: 1 MKSLYSRIVVTMLVVILSSSLLGFFFANIYYQIKLKPFNDEKTAKIAEEVQQFYQSNRAI 60 Query: 60 TVEEYLLSTASLGYKMYLSNDQGDERFYGLPFRKNDLKEGELQKVLAGSIYHGVADFPSR 119 +++EYL + LGY++YL++ + ++G FRK DL +Q+VLAG YHG+ F + Sbjct: 61 SLKEYLENVGELGYELYLTDGKDQSSYFGGAFRKKDLPNKTVQQVLAGETYHGIDTFDTG 120 Query: 120 MFITGFFDNQLSNTIGVPIHIHGQPYALFMRPDAQVQFGELRLFFAVLIAGTILFSLWFV 179 +FITGFFDN + NTIGVP+ G+ ALF+R D + QFGELR+FFA+++ T + S+ FV Sbjct: 121 IFITGFFDNDVRNTIGVPVKADGEQLALFIRQDPEQQFGELRIFFAMILVFTSIISILFV 180 Query: 180 LITVFHVVRPITRLTEATKKISKGRYDIKLYTARRDEIGQLASHFMSMSRELERTNRARQ 239 LI+ ++V+P+ +LT ATKKI +G YD+ L R+DEIGQLA F M+ ELE++ ARQ Sbjct: 181 LISGRYIVKPVVKLTNATKKIRRGNYDVALEVRRKDEIGQLADSFAKMASELEKSEAARQ 240 Query: 240 EFVANVSHEIESPLTSIQGFAHALKDGTLPEQQRMEYLSIIDQESRRLSVLSKQLLTLSS 299 EFVANVSHE++SPLTS+QGFA L GTL E+++ EYL+++ +E+ RLS L+KQLLTL+S Sbjct: 241 EFVANVSHELQSPLTSMQGFARLLGSGTLTEKEQKEYLTVLSEETTRLSSLTKQLLTLAS 300 Query: 300 LDYDENALDRKSIELRAQLRQVLQIMEWRLTEKELAVRLQVADITLQGDANLLYQVWMNL 359 LD + ++ ++L Q RQ++Q+ EW EKEL + L++ADI GDA LLYQVW NL Sbjct: 301 LDQESELRKKEPVQLAEQWRQLIQMTEWSWREKELTINLELADINYSGDAELLYQVWSNL 360 Query: 360 LSNAIKYTQTGGTIAISAKAENQHCMVTVTDNGEGIPADQLPMIFDRFYKVDRARTRDSN 419 L+NAIKYT GG I + E + V V ++G GI + + IFDRFYK ++RTR+ Sbjct: 361 LNNAIKYTPLGGNIQVRLYEETTNVFVEVWNSGAGISKEDMAKIFDRFYKASQSRTREEG 420 Query: 420 SSGLGLSIVRKIIEVHGGTVEATSTVGEGTTFTVTLP 456 SSGLGLSI +KII +H G + S +GTTF V LP Sbjct: 421 SSGLGLSICKKIITLHHGEITVESNTDKGTTFKVKLP 457 >ref|NP_832968.1| Two component system histidine kinase [Bacillus cereus ATCC 14579] gb|AAP10169.1| Two component system histidine kinase [Bacillus cereus ATCC 14579] Length = 458 Score = 454 bits (1168), Expect = e-126, Method: Compositional matrix adjust. Identities = 214/457 (46%), Positives = 314/457 (68%), Gaps = 1/457 (0%) Query: 1 MKSLYVRMSLLFCSVIVISSVLGFLISNAYYQAAIKPQNDAKLTKMAIGLQSFIEDHPDT 60 MKSLY R + ++++SS++GFL++N YYQ +KP N K+ K A ++S E + Sbjct: 1 MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQVKLKPYNSEKILKYAEEVKSLYEKQSEE 60 Query: 61 VEE-YLLSTASLGYKMYLSNDQGDERFYGLPFRKNDLKEGELQKVLAGSIYHGVADFPSR 119 +E YL S A LGY++Y+ +DQ + + G FRK + + + KVL G ++GV+ +P+R Sbjct: 61 NQETYLHSIAKLGYEIYIVDDQKNGKRIGNAFRKTSISDATVHKVLQGETFNGVSTYPTR 120 Query: 120 MFITGFFDNQLSNTIGVPIHIHGQPYALFMRPDAQVQFGELRLFFAVLIAGTILFSLWFV 179 +FITGFFDN+L N++GVP+ + YALF+RPD Q QFGE+R+F AVL+ +L S+ F+ Sbjct: 121 LFITGFFDNELINSVGVPVKHGDKQYALFIRPDIQNQFGEMRIFLAVLLGFIVLLSIIFI 180 Query: 180 LITVFHVVRPITRLTEATKKISKGRYDIKLYTARRDEIGQLASHFMSMSRELERTNRARQ 239 I ++VRPI + T+AT+KI+ G Y I+L R+DEIG L++ F M++ ++ + RQ Sbjct: 181 AIAAGYIVRPIRKFTKATQKIASGEYKIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ 240 Query: 240 EFVANVSHEIESPLTSIQGFAHALKDGTLPEQQRMEYLSIIDQESRRLSVLSKQLLTLSS 299 EFV+NVSHE +SPL+SIQGF+ L+ + E++R YL II+ ES+R+S L KQLLTL+S Sbjct: 241 EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSEEERNHYLQIIEGESKRMSSLCKQLLTLAS 300 Query: 300 LDYDENALDRKSIELRAQLRQVLQIMEWRLTEKELAVRLQVADITLQGDANLLYQVWMNL 359 LD +E L K L+ Q++ V+ ++EW+ EK++AV V DIT+QGD NLL+QVW N+ Sbjct: 301 LDKEEKVLQIKDFSLQKQIKDVIFMLEWKWREKDIAVEFDVPDITIQGDENLLHQVWSNI 360 Query: 360 LSNAIKYTQTGGTIAISAKAENQHCMVTVTDNGEGIPADQLPMIFDRFYKVDRARTRDSN 419 +N+IK++ GGTI + +++++DNG G+ +++ IFDRFYKVD AR R+ Sbjct: 361 FTNSIKFSNDGGTIEFFVEELESSVIISISDNGIGMEKEEMDRIFDRFYKVDTARARNVE 420 Query: 420 SSGLGLSIVRKIIEVHGGTVEATSTVGEGTTFTVTLP 456 SGLGLSIV+KI+E+H GTV ST GEGTT V LP Sbjct: 421 GSGLGLSIVQKIVELHKGTVSVYSTKGEGTTVRVELP 457 >ref|NP_466105.1| similar to two-component sensor histidine kinase [Listeria monocytogenes EGD-e] pir||AF1397 two-component sensor histidine kinase homolog lmo2582 [imported] - Listeria monocytogenes (strain EGD-e) emb|CAD00660.1| lmo2582 [Listeria monocytogenes] Length = 459 Score = 454 bits (1167), Expect = e-126, Method: Compositional matrix adjust. Identities = 224/457 (49%), Positives = 309/457 (67%), Gaps = 1/457 (0%) Query: 1 MKSLYVRMSLLFCSVIVISSVLGFLISNAYYQAAIKPQNDAKLTKMAIGLQSFIEDHPD- 59 MKSLY R+ + VI+ SS+LGF +N YYQ +K ND K K+A +Q F E + Sbjct: 1 MKSLYSRIVVTMLVVILSSSLLGFFFANIYYQIKLKLFNDEKTAKIAKEVQQFYESNATI 60 Query: 60 TVEEYLLSTASLGYKMYLSNDQGDERFYGLPFRKNDLKEGELQKVLAGSIYHGVADFPSR 119 ++ EYL + LGY++YL++ ++G FRK DL + +++VL G YHG+ F + Sbjct: 61 SLNEYLENVGELGYELYLTDGAEKSTYFGGAFRKKDLPDKTIKQVLDGDTYHGIDSFDTG 120 Query: 120 MFITGFFDNQLSNTIGVPIHIHGQPYALFMRPDAQVQFGELRLFFAVLIAGTILFSLWFV 179 +FITGFFDN + NTIGVP+ + G+ ALF+R D + QFGELR+FFA+++ T + S+ FV Sbjct: 121 IFITGFFDNDVRNTIGVPVQVDGKQLALFIRQDPEQQFGELRIFFAMILIFTSIISILFV 180 Query: 180 LITVFHVVRPITRLTEATKKISKGRYDIKLYTARRDEIGQLASHFMSMSRELERTNRARQ 239 LI+ ++V P+ +LT ATKKI KG YD+ R+DEIGQLA F M+ ELE++ ARQ Sbjct: 181 LISGRYIVNPVVKLTNATKKIRKGNYDVAFEVRRKDEIGQLADSFTKMASELEKSEAARQ 240 Query: 240 EFVANVSHEIESPLTSIQGFAHALKDGTLPEQQRMEYLSIIDQESRRLSVLSKQLLTLSS 299 EFVANVSHE++SPLTS+QGFA L GTL E+++ EYL+++ +E+ RLS L+KQLLTL+S Sbjct: 241 EFVANVSHELQSPLTSMQGFARLLGSGTLTEKEQAEYLTVLSEETTRLSSLTKQLLTLAS 300 Query: 300 LDYDENALDRKSIELRAQLRQVLQIMEWRLTEKELAVRLQVADITLQGDANLLYQVWMNL 359 LD + ++ + L Q RQ++Q+ EW EKEL + L +AD+ GDA LLYQVW NL Sbjct: 301 LDQESELRKKEPVHLAKQWRQLIQMTEWSWREKELTINLDLADVNYTGDAELLYQVWSNL 360 Query: 360 LSNAIKYTQTGGTIAISAKAENQHCMVTVTDNGEGIPADQLPMIFDRFYKVDRARTRDSN 419 L+NAIK+T GG I + + + V V D+G GI + IFDRFYK + +RTR+ Sbjct: 361 LTNAIKFTPQGGNIQVRLYEDTTNVFVEVQDSGVGISKVDMTKIFDRFYKANESRTREEG 420 Query: 420 SSGLGLSIVRKIIEVHGGTVEATSTVGEGTTFTVTLP 456 SSGLGLSI +KII +H G V S++ +GTTFTV LP Sbjct: 421 SSGLGLSICQKIITLHHGEVTVQSSLEKGTTFTVKLP 457 >ref|NP_845559.1| sensor histidine kinase [Bacillus anthracis str. Ames] gb|AAP27045.1| sensor histidine kinase [Bacillus anthracis str. Ames] Length = 458 Score = 447 bits (1149), Expect = e-124, Method: Compositional matrix adjust. Identities = 210/457 (45%), Positives = 312/457 (68%), Gaps = 1/457 (0%) Query: 1 MKSLYVRMSLLFCSVIVISSVLGFLISNAYYQAAIKPQNDAKLTKMAIGLQSFIEDHPDT 60 MKSLY R + ++++SS++GFL++N YYQ +KP N K+ K A ++S E + Sbjct: 1 MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQVKLKPYNSEKILKYAEEVKSLYEKQSEE 60 Query: 61 VEE-YLLSTASLGYKMYLSNDQGDERFYGLPFRKNDLKEGELQKVLAGSIYHGVADFPSR 119 +E YL S A LGY++Y+ +DQ + + G FRK + + ++KVL G ++GV+ +P+R Sbjct: 61 NQEAYLQSIAKLGYEIYIVDDQKNGKRIGNAFRKTTISDDTIRKVLNGETFNGVSTYPTR 120 Query: 120 MFITGFFDNQLSNTIGVPIHIHGQPYALFMRPDAQVQFGELRLFFAVLIAGTILFSLWFV 179 +FITGFFDN+L N++GVP+ + YALF+RPD Q QFGE+R+F AVL+ +L S+ F+ Sbjct: 121 LFITGFFDNELINSVGVPLKHGDKQYALFIRPDIQNQFGEMRIFLAVLLGFIVLLSIIFI 180 Query: 180 LITVFHVVRPITRLTEATKKISKGRYDIKLYTARRDEIGQLASHFMSMSRELERTNRARQ 239 I ++VRPI + T AT+KI+ G Y+I+L R+DEIG L++ F M++ ++ + RQ Sbjct: 181 AIAAGYIVRPIRKFTNATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ 240 Query: 240 EFVANVSHEIESPLTSIQGFAHALKDGTLPEQQRMEYLSIIDQESRRLSVLSKQLLTLSS 299 EFV+NVSHE +SPL+SIQGF+ L+ + ++R YL II+ ES+R+S L KQLLTL+S Sbjct: 241 EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSVEERNHYLQIIEGESKRMSSLCKQLLTLAS 300 Query: 300 LDYDENALDRKSIELRAQLRQVLQIMEWRLTEKELAVRLQVADITLQGDANLLYQVWMNL 359 LD +E L K L+ Q++ V+ ++EW+ EK +A+ V DIT++GD NLL+QVW N+ Sbjct: 301 LDKEEKVLQIKEFNLQKQIKDVIFMLEWKWREKNIAIEFDVPDITIKGDENLLHQVWSNI 360 Query: 360 LSNAIKYTQTGGTIAISAKAENQHCMVTVTDNGEGIPADQLPMIFDRFYKVDRARTRDSN 419 +N+IK++ GGTI + +++++DNG G+ +++ IFDRFYKVD AR R+ Sbjct: 361 FTNSIKFSNEGGTIEFFVEELESSVIISISDNGIGMEKEEMDRIFDRFYKVDTARARNVE 420 Query: 420 SSGLGLSIVRKIIEVHGGTVEATSTVGEGTTFTVTLP 456 SGLGLSIV+KI+E+H G V ST GEGTT V LP Sbjct: 421 GSGLGLSIVQKIVELHNGNVSVYSTKGEGTTVRVELP 457 >ref|NP_979572.1| sensor histidine kinase [Bacillus cereus ATCC 10987] gb|AAS42180.1| sensor histidine kinase [Bacillus cereus ATCC 10987] Length = 458 Score = 447 bits (1149), Expect = e-124, Method: Compositional matrix adjust. Identities = 210/457 (45%), Positives = 312/457 (68%), Gaps = 1/457 (0%) Query: 1 MKSLYVRMSLLFCSVIVISSVLGFLISNAYYQAAIKPQNDAKLTKMAIGLQSFIEDHPDT 60 MKSLY R + ++++SS++GFL++N YYQ +KP N K+ K A ++S E + Sbjct: 1 MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQVKLKPYNSEKILKYAEEVKSLYEKQSEE 60 Query: 61 VEE-YLLSTASLGYKMYLSNDQGDERFYGLPFRKNDLKEGELQKVLAGSIYHGVADFPSR 119 +E YL S A LGY++Y+ +DQ + + G FRK + + + KVL G ++GV+ +P+R Sbjct: 61 NQEAYLQSIAKLGYEIYIVDDQKNGKRIGNAFRKTSISDDTVHKVLQGETFNGVSTYPTR 120 Query: 120 MFITGFFDNQLSNTIGVPIHIHGQPYALFMRPDAQVQFGELRLFFAVLIAGTILFSLWFV 179 +FITGFFDN+L N++GVP+ + YALF+RPD Q QFGE+R+F AVL+ +L S+ F+ Sbjct: 121 LFITGFFDNELINSVGVPVKHGDKQYALFIRPDIQNQFGEMRIFLAVLLGFIVLLSIIFI 180 Query: 180 LITVFHVVRPITRLTEATKKISKGRYDIKLYTARRDEIGQLASHFMSMSRELERTNRARQ 239 I ++VRPI + T+AT+KI+ G Y+I+L R+DEIG L++ F M++ ++ + RQ Sbjct: 181 AIAAGYIVRPIRKFTKATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ 240 Query: 240 EFVANVSHEIESPLTSIQGFAHALKDGTLPEQQRMEYLSIIDQESRRLSVLSKQLLTLSS 299 EFV+NVSHE +SPL+SIQGF+ L+ + ++R YL II+ ES+R+S L KQLLTL+S Sbjct: 241 EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSMEERNHYLQIIEGESKRMSSLCKQLLTLAS 300 Query: 300 LDYDENALDRKSIELRAQLRQVLQIMEWRLTEKELAVRLQVADITLQGDANLLYQVWMNL 359 LD +E L K L+ Q++ V+ ++EW+ EK++AV V DI ++GD NLL+QVW N+ Sbjct: 301 LDKEEKVLQIKEFNLQKQIKDVIFMLEWKWREKDIAVEFDVPDIVIKGDENLLHQVWSNI 360 Query: 360 LSNAIKYTQTGGTIAISAKAENQHCMVTVTDNGEGIPADQLPMIFDRFYKVDRARTRDSN 419 +N+IK++ GGTI + +++++DNG G+ +++ IFDRFYKVD AR R+ Sbjct: 361 FTNSIKFSNDGGTIEFFVEELESSVIISISDNGIGMEQEEMDRIFDRFYKVDTARARNVE 420 Query: 420 SSGLGLSIVRKIIEVHGGTVEATSTVGEGTTFTVTLP 456 SGLGLSIV+KI+E+H G V ST GEGTT V LP Sbjct: 421 GSGLGLSIVQKIVELHNGNVSVYSTKGEGTTVRVELP 457 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.321 0.136 0.384 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 620,480,618 Number of extensions: 24793823 Number of successful extensions: 89127 Number of sequences better than 1.0e-05: 5792 Number of HSP's gapped: 80650 Number of HSP's successfully gapped: 5823 Length of query: 458 Length of database: 757,237,578 Length adjustment: 129 Effective length of query: 329 Effective length of database: 406,989,807 Effective search space: 133899646503 Effective search space used: 133899646503 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 128 (53.9 bits)