BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0560.0026.p (2351 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value sp|O30408|TYCB_BREPA Tyrocidine synthetase II [Includes: ATP-dep... 1509 0.0 sp|O30409|TYCC_BREPA Tyrocidine synthetase III [Includes: ATP-de... 1442 0.0 pir||JX0340 gramicidin S synthase 2 - Bacillus brevis >gi|511490... 1364 0.0 sp|P14688|GRSB_BACBR Gramicidin S synthetase II [Includes: ATP-d... 1326 0.0 sp|O68008|BACC_BACLI Bacitracin synthetase 3 (BA3) [Includes: AT... 1325 0.0 >sp|O30408|TYCB_BREPA Tyrocidine synthetase II [Includes: ATP-dependent proline adenylase (ProA) (Proline activase); ATP-dependent phenylalanine adenylase (PheA) (Phenylalanine activase); ATP-dependent D-phenylalanine adenylase (D-PheA) (D-phenylalanine activase); Phenylalanine racemase [ATP-hydrolyzing] ] pir||T31075 tyrocidine synthetase 2 - Brevibacillus brevis gb|AAC45929.1| tyrocidine synthetase 2 [Brevibacillus brevis] Length = 3587 Score = 1509 bits (3906), Expect = 0.0, Method: Compositional matrix adjust. Identities = 785/1888 (41%), Positives = 1167/1888 (61%), Gaps = 39/1888 (2%) Query: 14 TSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQHLSNR 72 T++ +K++KYWL+R G + D P + EG+ L L + LQ ++ + Sbjct: 1232 TTDYQKQEKYWLDRFAGEIPVLNLPMDYPRPAVQSFEGERYL-FRTEKQLLESLQDVAQK 1290 Query: 73 SDDSLYYILLTALKWLIVKHTESSIITV----ASPVYMDENSTSEAYNHYVPIIDTFTTG 128 + +LY +LL A L+ K++ + + A V+ D S + + + + + + Sbjct: 1291 TGTTLYMVLLAAYHVLLSKYSGQDDVMIGTVTAGRVHPDTESMTGMFVNTLAMRNQSAPT 1350 Query: 129 MTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHND---- 184 TFR+ LL+V++ TL A++H YPF++++E + +R + + L +L N+ D Sbjct: 1351 KTFRQFLLEVKDNTLAAFEHGQYPFEELVEKLAIQRNRSRNPLFDTLFILQNMDADLIEL 1410 Query: 185 ---AVIPDVGSNIVFGF------TRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQILKGA 235 V P V V F + + AG+S + K F R + +++ Y QIL+ Sbjct: 1411 DGLTVTPYVPEGEVAKFDLSLEASENQAGLSFCFEFCTKLFARETIERMSLHYLQILQAV 1470 Query: 236 AENVSIKLGS--MXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQTPDHVAVKFN 293 + N +L M T E TL +LFE Q ++TP+ AV F Sbjct: 1471 SANTEQELAQIEMLTAHEKQELLVHFNDTAALYPAES-TLSQLFEDQAQKTPEQTAVVFG 1529 Query: 294 NQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLPLDI 353 ++ +TYR+LN +AN+LA LR +GV A Q VG++ +RS++MA GI+ ILK+G AY+P+D Sbjct: 1530 DKRLTYRELNERANQLAHTLRAKGVQAEQSVGIMAQRSLEMAIGIIAILKAGGAYVPIDP 1589 Query: 354 KSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDLILGRALD 413 P ER+ +++ED + ++ +Q EK+ + + + LD++ +++ + A D Sbjct: 1590 DYPNERIAYMLEDCR-RLVLTQQQLAEKMTAN-VECLYLDEEGSYSPQTENIEPIHTAAD 1647 Query: 414 HPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGFLTSFF 473 AY+IYTSGTTG+PKGV++EHR I N++ W + E++ D S+ FD F +FF Sbjct: 1648 L-AYIIYTSGTTGRPKGVMVEHRGIVNSVTWNRDEFALSVRDSGTLSLSFAFDAFALTFF 1706 Query: 474 TPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQSLRIV 533 T IVSG+TVV + + EA+DP+A+ LI + ++ + VP+++ A+L P + +S++ V Sbjct: 1707 TLIVSGSTVVLMPDHEAKDPIALRNLIAAWECSYVVFVPSMFQAILECSTPADIRSIQAV 1766 Query: 534 TLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELTIGKPIGNTR 593 L GEK++P L+ K +HP M ++N YGPTESSV+AT RD +PD +TIG+PI NT Sbjct: 1767 MLGGEKLSPKLVQLCKAMHPQMSVMNAYGPTESSVMATYLRDTQPDQP-ITIGRPIANTA 1825 Query: 594 VYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYRTGDLAR 653 +YIV + +L G+VGE+CI G GLARGY LT +KFV+NP ERMY+TGDL R Sbjct: 1826 IYIVDQHHQLLPVGVVGEICIGGHGLARGYWKKPELTAEKFVANPAVPGERMYKTGDLGR 1885 Query: 654 WTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNSRICAYI 713 W G I+ IGR D Q+K+RGYRIE+GEIE LL Y+ EA+V ++D +S + AY+ Sbjct: 1886 WLHDGTIDFIGRVDDQIKVRGYRIEVGEIEAVLLAYDQTNEAIVVAYQDDRGDSYLAAYV 1945 Query: 714 VCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLKELGARF 773 + ELR L + LP YM+PT+ QL+ FP+TP GK+DR AL + GA + Sbjct: 1946 TGKTAIEESELRAHLLRELPAYMVPTYLIQLDAFPLTPNGKVDRKALPKPEGKPATGAAY 2005 Query: 774 QHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVEIELDEI 833 P E+E++LV IW+N L + V + D+FF LGGHSLKA +++++H+EFQ+++ L + Sbjct: 2006 VAPATEVEAKLVAIWENALGISGVGVLDHFFELGGHSLKAMTVVAQVHREFQIDLLLKQF 2065 Query: 834 FEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTSYNMPEV 893 F TI +LA LI+ ++I P E + YYP+SSAQ+RMY L+ LEG SYN P + Sbjct: 2066 FAAPTIRDLARLIEHSEQAAGAAIQPAEPQAYYPVSSAQQRMYLLHQLEGAGISYNTPGI 2125 Query: 894 MVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYT---EEKID 950 +++EG+LD Q+ + L+ ++ RH+ILRTSF M+ E VQ +HD + +++Y E++ID Sbjct: 2126 IMLEGKLDREQLANALQALVDRHDILRTSFEMVGDELVQKIHDRVAVNMEYVTAEEQQID 2185 Query: 951 DIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLY 1010 D+ F++PFDL PL R+ ++K+A +L ++DMHHI +D SI + ELA LY Sbjct: 2186 DL---FHAFVRPFDLSVPPLLRMSLVKLADERHLLLYDMHHIAADAASITILFDELAELY 2242 Query: 1011 GNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSY 1070 LPE IQ+KDF+VW+K E+ FKQQE +WL F G + +++P D+ RP KS+ Sbjct: 2243 QGRELPEMRIQYKDFAVWQKALHESDAFKQQEAYWLSTFAGNITAVDVPTDFPRPAVKSF 2302 Query: 1071 EGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQ 1130 G ++ ++D+E L ELA TL+M+LLA +N++L+K Q+DIIVG+P++ R + Sbjct: 2303 AGGQVTLSMDQELLSALHELAAHTNTTLFMVLLAAYNVLLAKYAGQDDIIVGTPISGRSR 2362 Query: 1131 VELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRD 1190 EL V+GMF +TLA+RN P K FK FL EVK +AL AFD+QDY FE ++ KL I RD Sbjct: 2363 AELAPVVGMFVHTLAIRNKPTAEKTFKQFLQEVKQNALDAFDHQDYPFESLVEKLGIPRD 2422 Query: 1191 TGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEH--NISRFDITLHCLEGLDGLLHCSF 1248 GRNPLFD M ILQN ++ ++ YE + ++++FD++ H E L Sbjct: 2423 PGRNPLFDTMFILQNDELHAKTLDQLVYRPYESDSALDVAKFDLSFHLTERETDLF-LRL 2481 Query: 1249 EYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLP 1307 EYCT+LFK++TVE M + I+ V A+ E + +I M++ Q +L AFN T + Sbjct: 2482 EYCTKLFKQQTVERMAHHFLQILRAVTANPENELQEIEMLTAAEKQMLLVAFNDTHREYR 2541 Query: 1308 ADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMF 1367 ADQTI LFEE A++ + AL F ++ MS+ ELN+RANQLA +LREKGV +V L+ Sbjct: 2542 ADQTIQQLFEELAEKMPEHTALVFEEKRMSFRELNERANQLAAVLREKGVGPAQIVALLV 2601 Query: 1368 ERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEV 1427 ERS EM+I L LK+GGA+LP+DPDYP ERI++M+EDS +LV+T + + EV Sbjct: 2602 ERSAEMVIATLATLKAGGAFLPVDPDYPEERIRYMLEDSQAKLVVTHAHLLHKVSSQSEV 2661 Query: 1428 IDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLK 1487 +D++ G NLP N SDLAY+IYTSGTTGKPKG +LEHKG+ NL A L Sbjct: 2662 VDVDDPGSYATQTDNLPCANTPSDLAYIIYTSGTTGKPKGVMLEHKGVANLQAVFAHHLG 2721 Query: 1488 IQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAIL 1547 + ++R F+SISFD S+ D+ +L G TL + +++++ND F ++ N IT L Sbjct: 2722 VTPQDRAGHFASISFDASVWDMFGPLLSGATLYVLSRDVINDFQRFAEYVRDNAITFLTL 2781 Query: 1548 PPTYLANLNPNNIHTVDKMITIGSAISSGLVNEWKRKCEYINAYGPTETTVYSSVWIANK 1607 PPTY L P + ++ +IT GSA S LV++WK K Y+N YGPTE+TV +++W A K Sbjct: 2782 PPTYAIYLEPEQVPSLRTLITAGSASSVALVDKWKEKVTYVNGYGPTESTVCATLWKA-K 2840 Query: 1608 QGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKII 1667 E + + IGKPI NT++YI+D L+ G GELCI G+ L RGYW RPE+TA+K + Sbjct: 2841 PDEPVETITIGKPIQNTKLYIVDDQLQLKAPGQMGELCISGLSLARGYWNRPELTAEKFV 2900 Query: 1668 TAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKD- 1726 K+YRTGDLARWLPDG +EYLGR+D QVKIRG RVE E+++ LL+ + +K+ Sbjct: 2901 DNPFVPGTKMYRTGDLARWLPDGTIEYLGRIDHQVKIRGHRVELGEVESVLLRYDTVKEA 2960 Query: 1727 VIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGK 1786 +TH ++ Q A +CAYY++ + + +LR + ++LP +M+PA+F+++E PLT N K Sbjct: 2961 AAITHEDDRGQ-AYLCAYYVAEGEATPAQLRAYMENELPNYMVPAFFIQLEKMPLTPNDK 3019 Query: 1787 IDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAM 1846 ID+K LP P R Y P+ E+E +LA +W +VL +++VG +DNFFE+GGDS+KA+ Sbjct: 3020 IDRKALPKPNQEENRTEQYAAPQTELEQLLAGIWADVLGIKQVGTQDNFFELGGDSIKAI 3079 Query: 1847 QVAAILGKHRLHMEIKDLFHRQKIAELS 1874 QV+ L + +K+LF I E + Sbjct: 3080 QVSTRLNASGWTLAMKELFQYPTIEEAA 3107 Score = 1270 bits (3287), Expect = 0.0, Method: Compositional matrix adjust. Identities = 741/2018 (36%), Positives = 1139/2018 (56%), Gaps = 129/2018 (6%) Query: 119 VPIIDTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKI-IEDVQAISDRDFSFVRHVLC- 176 +P G TF E L V + TL Q P++ + + D+Q S + H+L Sbjct: 302 IPFRVQAKAGQTFSELLQAVHKRTL-----QSQPYEHVPLYDIQTQSVLKQELIDHLLVI 356 Query: 177 ----LLTNIHNDAVIPDVGSNI----VFGFTRDDAGI--------SLNLIYNLKYFTRNF 220 L+ + A+ +G I +F T D + + YN F Sbjct: 357 ENYPLVEALQKKALNQQIGFTITAVEMFEPTNYDLTVMVMPKEELAFRFDYNAALFDEQV 416 Query: 221 VMQLAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQ 280 V +LA QI A N ++L + +T T + T++ELF +Q Sbjct: 417 VQKLAGHLQQIADCVANNSGVELCQIPLLTEAETSQLLAKRTETAADYPAATMHELFSRQ 476 Query: 281 VRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILG 340 +TP+ VAV F +Q +TYR+L+ K+N+LAR LR +G+G +VG L++RS+DM GILG Sbjct: 477 AEKTPEQVAVVFADQHLTYRELDEKSNQLARFLRKKGIGTGSLVGTLLDRSLDMIVGILG 536 Query: 341 ILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLEN 400 +LK+G A++P+D + P ER+ +++ + + + V+ K+ T I ++ V+ E Sbjct: 537 VLKAGGAFVPIDPELPAERIAYMLTHSRVPLVVTQNHLRAKVTTPTET-IDINTAVIGE- 594 Query: 401 ESDLDLILGRALDHPA---YVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRM 457 ES + +L+ P Y+IYTSGTTGQPKGV++EHR+++N + + + + +++ Sbjct: 595 ESRAPI---ESLNQPHDLFYIIYTSGTTGQPKGVMLEHRNMANLMHFTFDQTNIAFHEKV 651 Query: 458 LQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSA 517 LQ + FD F+ ++SG + + R + I +I+ +++P + Sbjct: 652 LQYTTCSFDVCYQEIFSTLLSGGQLYLITNELRRHVEKLFAFIQEKQIS-ILSLPVSFLK 710 Query: 518 LLRNMKPEEAQS----LRIVTLAGEKVTPNLLIASKQLHPGME-----IVNEYGPTESSV 568 + N + + AQS ++ + AGE+ L+ + +L + + N YGP+E+ V Sbjct: 711 FIFNEQ-DYAQSFPRCVKHIITAGEQ-----LVVTHELQKYLRQHRVFLHNHYGPSETHV 764 Query: 569 LATLKRDLKPDDTELT-IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNE 627 + T D EL IGKPI NT +YI+ + L+LK G+VGEL ISGA + RGYLH Sbjct: 765 VTTCTMDPGQAIPELPPIGKPISNTGIYILDEGLQLKPEGIVGELYISGANVGRGYLHQP 824 Query: 628 VLTRDKFVSNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLL 687 LT +KF+ NP++ ERMYRTGDLA W G++E +GR D QVK+RG+RIELGEIE+RLL Sbjct: 825 ELTAEKFLDNPYQPGERMYRTGDLALWLPDGQLEFLGRIDHQVKIRGHRIELGEIESRLL 884 Query: 688 EYNGITEAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQF 747 + I EAVV D+ +CAY+V + LS E+R L+++LPEYM+P+ F LE+ Sbjct: 885 NHPAIKEAVVIDRADETGGKFLCAYVVLQKALSDEEMRAYLAQALPEYMIPSFFVTLERI 944 Query: 748 PMTPTGKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLG 807 P+TP GK DR AL + + A + PT E+E +LV IW+ +L V + I D+FF LG Sbjct: 945 PVTPNGKTDRRALPKPEGSAKTKADYVAPTTELEQKLVAIWEQILGVSPIGIQDHFFTLG 1004 Query: 808 GHSLKATMLLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYP 867 GHSLKA L+SR+ KE Q ++ L +FE+ TI LAA ++ Y +I E + YYP Sbjct: 1005 GHSLKAIQLISRIQKECQADVPLRVLFEQPTIQALAAYVEGGEESAYLAIPQAEPQAYYP 1064 Query: 868 MSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIH 927 +SSAQKRM L L+ ST YN+P M++EG LD ++E + +++RHE LRTSFH I+ Sbjct: 1065 VSSAQKRMLILNQLDPHSTVYNLPVAMILEGTLDKARLEHAISNLVARHESLRTSFHTIN 1124 Query: 928 HEPVQVVHDTIDFSIDY---TEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYL 984 EPV +H+ I Y EE+++++ L F+QPFDL T+PL RV ++K+A ++ Sbjct: 1125 GEPVSRIHEQGHLPIVYLETAEEQVNEVIL---GFMQPFDLVTAPLCRVGLVKLAENRHV 1181 Query: 985 FMFDMHHIISDGISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEF 1044 + DMHHIISDG+S L + + + LY N LPE I +KDF+VWEK + D+++QE++ Sbjct: 1182 LIIDMHHIISDGVSSQLILNDFSRLYQNKALPEQRIHYKDFAVWEKAWTQTTDYQKQEKY 1241 Query: 1045 WLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLA 1104 WL F GE+P+L LP+DY RP +S+EG + F +K+ L+++A G TLYM+LLA Sbjct: 1242 WLDRFAGEIPVLNLPMDYPRPAVQSFEGERYLFRTEKQLLESLQDVAQKTGTTLYMVLLA 1301 Query: 1105 LFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVK 1164 ++++LSK + Q+D+++G+ R + ES+ GMF NTLAMRN A K F+ FL EVK Sbjct: 1302 AYHVLLSKYSGQDDVMIGTVTAGRVHPDTESMTGMFVNTLAMRNQSAPTKTFRQFLLEVK 1361 Query: 1165 SSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHE 1224 + L+AF++ Y FEE++ KL I R+ RNPLFD + ILQN+ + + + V+ Y E Sbjct: 1362 DNTLAAFEHGQYPFEELVEKLAIQRNRSRNPLFDTLFILQNMDADLIELDGLTVTPYVPE 1421 Query: 1225 HNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISD 1284 +++FD++L E GL C FE+CT+LF RET+E M + I+ V A+ E ++ Sbjct: 1422 GEVAKFDLSLEASENQAGLSFC-FEFCTKLFARETIERMSLHYLQILQAVSANTEQELAQ 1480 Query: 1285 ICMVSENAVQQILA-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNK 1343 I M++ + Q++L FN T+ PA+ T+ LFE+QA++ ++ A+ F D+ ++Y ELN+ Sbjct: 1481 IEMLTAHEKQELLVHFNDTAALYPAESTLSQLFEDQAQKTPEQTAVVFGDKRLTYRELNE 1540 Query: 1344 RANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMI 1403 RANQLA LR KGV A VG+M +RS EM IG + ILK+GGAY+PIDPDYP ERI +M+ Sbjct: 1541 RANQLAHTLRAKGVQAEQSVGIMAQRSLEMAIGIIAILKAGGAYVPIDPDYPNERIAYML 1600 Query: 1404 EDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTG 1463 ED +LVLTQ + + E + L+ G + N+ I+ ++DLAY+IYTSGTTG Sbjct: 1601 EDCR-RLVLTQQQLAEKMTANVECLYLDEEGSYSPQTENIEPIHTAADLAYIIYTSGTTG 1659 Query: 1464 KPKGTLLEHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTT 1523 +PKG ++EH+GIVN N+++ + R+ S +FD + I+ G T+ L Sbjct: 1660 RPKGVMVEHRGIVNSVTWNRDEFALSVRDSGTLSLSFAFDAFALTFFTLIVSGSTVVLMP 1719 Query: 1524 KEILNDNSCFEAFLNSNRITAAILPPTYLANL----NPNNIHTVDKMITIGSAISSGLVN 1579 D + + + + P+ + P +I ++ ++ G +S LV Sbjct: 1720 DHEAKDPIALRNLIAAWECSYVVFVPSMFQAILECSTPADIRSIQAVMLGGEKLSPKLVQ 1779 Query: 1580 EWKR---KCEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQ 1636 K + +NAYGPTE++V ++ + + D P+ IG+PI NT +YI+D++ L Sbjct: 1780 LCKAMHPQMSVMNAYGPTESSVMATYL---RDTQPDQPITIGRPIANTAIYIVDQHHQLL 1836 Query: 1637 PVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLG 1696 PVG+ GE+CIGG GL RGYWK+PE+TA+K + ++Y+TGDL RWL DG ++++G Sbjct: 1837 PVGVVGEICIGGHGLARGYWKKPELTAEKFVANPAVPGERMYKTGDLGRWLHDGTIDFIG 1896 Query: 1697 RMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTEL 1756 R+D+Q+K+RG+R+E EI+A LL + + IV ++ + + AY +EL Sbjct: 1897 RVDDQIKVRGYRIEVGEIEAVLLAYDQTNEAIVVAYQDDRGDSYLAAYVTGKTAIEESEL 1956 Query: 1757 RKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELML 1816 R LL +LP +M+P Y ++++AFPLT NGK+D+K LP PE + Y+ P E+E L Sbjct: 1957 RAHLLRELPAYMVPTYLIQLDAFPLTPNGKVDRKALPKPEGKPATGAAYVAPATEVEAKL 2016 Query: 1817 AEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGKHRLHMEIK-DLFHRQKIAELSE 1875 +WE L + VG+ D+FFE+GG SLKAM V A ++H E + DL +Q A + Sbjct: 2017 VAIWENALGISGVGVLDHFFELGGHSLKAMTVVA-----QVHREFQIDLLLKQFFA--AP 2069 Query: 1876 CVRDLRNNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKH 1935 +RDL I+ S A+I+ P Sbjct: 2070 TIRDLAR---------LIEHSEQAAGAAIQ---------------------PAEPQAYYP 2099 Query: 1936 LPAAVQKYHLMNAEKVHTSIPFRSCGDI---GKIQK-----AILRLVNEQVLLRSVIVND 1987 + +A Q+ +L++ + I + + G I GK+ + A+ LV+ +LR+ Sbjct: 2100 VSSAQQRMYLLH-QLEGAGISYNTPGIIMLEGKLDREQLANALQALVDRHDILRTSFEMV 2158 Query: 1988 GENTYFYEHGSV-YNLPFILIDLSGFDAARRSECLAYLQDHFNKL--PFERDNGLLYRLV 2044 G+ H V N+ ++ + D D F+ PF+ L R+ Sbjct: 2159 GDELVQKIHDRVAVNMEYVTAEEQQID------------DLFHAFVRPFDLSVPPLLRMS 2206 Query: 2045 LVQTAPEDYMLLYSADHAVSDGLSLGIITDQLAAYFAG 2082 LV+ A E ++LLY H +D S+ I+ D+LA + G Sbjct: 2207 LVKLADERHLLLYDMHHIAADAASITILFDELAELYQG 2244 Score = 543 bits (1400), Expect = e-152, Method: Compositional matrix adjust. Identities = 383/1282 (29%), Positives = 649/1282 (50%), Gaps = 106/1282 (8%) Query: 863 RDYYPMSSAQKRMYALYH--LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILR 920 +D Y ++ Q+ M L+H L+ E S+ + + ++G+LDVG L ++ R+++ R Sbjct: 10 QDMYALTPMQEGM--LFHALLDQEHNSHLVQMSISLQGDLDVGLFTDSLHVLVERYDVFR 67 Query: 921 TSF-HMIHHEPVQVVHDTIDFSIDYTEEKIDDIRLEADRFIQ--------PFDLDTSPLF 971 T F + +P+QVV I++ + D + R+ Q F L PL Sbjct: 68 TLFLYEKLKQPLQVVLKQRPIPIEFYDLSACDESEKQLRYTQYKRADQERTFHLAKDPLM 127 Query: 972 RVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLY-----GNAVLPEPEIQFKDFS 1026 RV + +++ Y ++ HHI+ DG + +L +Y A+ EP + F Sbjct: 128 RVALFQMSQHDYQVIWSFHHILMDGWCFSIIFDDLLAIYLSLQNKTALSLEPVQPYSRFI 187 Query: 1027 VWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRK 1086 W ++ + +W + LP + K+++ ++ F+L++ T++ Sbjct: 188 NWLEKQNKQAALN----YWSDYLEAYEQKTTLP-KKEAAFAKAFQPTQYRFSLNRTLTKQ 242 Query: 1087 LKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQ--VELESVMGMFSNTL 1144 L +A N TL ++ ++ ++L K D++ GS V+ R V ++ ++G+F NT+ Sbjct: 243 LGTIASQNQVTLSTVIQTIWGVLLQKYNAAHDVLFGSVVSGRPTDIVGIDKMVGLFINTI 302 Query: 1145 AMRNFPAGNKRFKDFLNEVKSSALSA----------FDNQDYQFEEMISKLDIVRDTGRN 1194 R + F + L V L + Q +E+I L ++ + Sbjct: 303 PFRVQAKAGQTFSELLQAVHKRTLQSQPYEHVPLYDIQTQSVLKQELIDHLLVIENY--- 359 Query: 1195 PLFDAMLILQNIAVN-QFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTR 1253 PL +A LQ A+N Q F V +E + +D+T+ + + L F+Y Sbjct: 360 PLVEA---LQKKALNQQIGFTITAVEMFEP----TNYDLTVMVMPKEE--LAFRFDYNAA 410 Query: 1254 LFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILA-FNQTSFDLPADQTI 1312 LF + V+ + +L+ I + V + + + I +++E Q+LA +T+ D PA T+ Sbjct: 411 LFDEQVVQKLAGHLQQIADCVANNSGVELCQIPLLTEAETSQLLAKRTETAADYPA-ATM 469 Query: 1313 HGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFE 1372 H LF QA++ ++ A+ F DQ ++Y EL++++NQLAR LR+KG+ GS+VG + +RS + Sbjct: 470 HELFSRQAEKTPEQVAVVFADQHLTYRELDEKSNQLARFLRKKGIGTGSLVGTLLDRSLD 529 Query: 1373 MMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNC 1432 M++G LG+LK+GGA++PIDP+ P ERI +M+ S + LV+TQN + E ID+N Sbjct: 530 MIVGILGVLKAGGAFVPIDPELPAERIAYMLTHSRVPLVVTQNHLRAKVTTPTETIDINT 589 Query: 1433 AGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRE 1492 A + + + +N+ DL Y+IYTSGTTG+PKG +LEH+ + NL +Q I E Sbjct: 590 AVIGEESRAPIESLNQPHDLFYIIYTSGTTGQPKGVMLEHRNMANLMHFTFDQTNIAFHE 649 Query: 1493 RVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYL 1552 +V+Q+++ SFDV +I ++L GG L L T E+ AF+ +I+ LP ++L Sbjct: 650 KVLQYTTCSFDVCYQEIFSTLLSGGQLYLITNELRRHVEKLFAFIQEKQISILSLPVSFL 709 Query: 1553 A------NLNPNNIHTVDKMITIGSA-ISSGLVNEWKRKCEYI--NAYGPTETTVYSSVW 1603 + + V +IT G + + + ++ R+ N YGP+ET V ++ Sbjct: 710 KFIFNEQDYAQSFPRCVKHIITAGEQLVVTHELQKYLRQHRVFLHNHYGPSETHVVTTCT 769 Query: 1604 IANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTA 1663 + Q + P PIGKPI NT +YILD+ L+P GI GEL I G + RGY +PE+TA Sbjct: 770 MDPGQAIPELP-PIGKPISNTGIYILDEGLQLKPEGIVGELYISGANVGRGYLHQPELTA 828 Query: 1664 DKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEG 1723 +K + ++YRTGDLA WLPDG LE+LGR+D QVKIRG R+E EI++ LL Sbjct: 829 EKFLDNPYQPGERMYRTGDLALWLPDGQLEFLGRIDHQVKIRGHRIELGEIESRLLNHPA 888 Query: 1724 IKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTS 1783 IK+ +V R ++ +CAY + S E+R L LPE+MIP++FV +E P+T Sbjct: 889 IKEAVVIDRADETGGKFLCAYVVLQKALSDEEMRAYLAQALPEYMIPSFFVTLERIPVTP 948 Query: 1784 NGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSL 1843 NGK D++ LP PE S + + Y+ P E+E L +WE++L + +GI+D+FF +GG SL Sbjct: 949 NGKTDRRALPKPEGSAKTKADYVAPTTELEQKLVAIWEQILGVSPIGIQDHFFTLGGHSL 1008 Query: 1844 KAMQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSSGTEGDAS 1903 KA+Q+ + + K EC D+ + E P + ++ EG Sbjct: 1009 KAIQLISRIQK--------------------ECQADVPLRVLFEQPTIQALAAYVEGGEE 1048 Query: 1904 IEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIPFRSCGDI 1963 L + + + Q S + L+ L Y+L A + ++ D Sbjct: 1049 SAYLA---IPQAEPQAYYPVSSAQKRMLILNQLDPHSTVYNLPVAMILEGTL------DK 1099 Query: 1964 GKIQKAILRLVNEQVLLRSVI--VNDGENTYFYEHGSVYNLPFILIDLSGFDAARRSECL 2021 +++ AI LV LR+ +N + +E G +LP + ++ + + L Sbjct: 1100 ARLEHAISNLVARHESLRTSFHTINGEPVSRIHEQG---HLPIVYLETA--EEQVNEVIL 1154 Query: 2022 AYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQLAAYFA 2081 ++Q PF+ L R+ LV+ A ++L+ H +SDG+S +I + + + Sbjct: 1155 GFMQ------PFDLVTAPLCRVGLVKLAENRHVLIIDMHHIISDGVSSQLILNDFSRLYQ 1208 Query: 2082 GDSSLPVHSLKHHQNY--WDYA 2101 + +LP + H++++ W+ A Sbjct: 1209 -NKALPEQRI-HYKDFAVWEKA 1228 Score = 510 bits (1314), Expect = e-142, Method: Compositional matrix adjust. Identities = 347/1128 (30%), Positives = 556/1128 (49%), Gaps = 62/1128 (5%) Query: 1 MSIQNANINV----LLSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRL 56 M IQ + V L + K+++ YWL+ G+ T + TD + A+ + L Sbjct: 2250 MRIQYKDFAVWQKALHESDAFKQQEAYWLSTFAGNITAVDVPTDFPRPAVKSFAGGQVTL 2309 Query: 57 DIPDGLFQQLQHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSE--- 113 + L L L+ ++ +L+ +LL A L+ K+ I V +P+ S +E Sbjct: 2310 SMDQELLSALHELAAHTNTTLFMVLLAAYNVLLAKYAGQDDIIVGTPI--SGRSRAELAP 2367 Query: 114 ---AYNHYVPIIDTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSF 170 + H + I + T TF++ L +V++ L A+DHQDYPF+ ++E + D + Sbjct: 2368 VVGMFVHTLAIRNKPTAEKTFKQFLQEVKQNALDAFDHQDYPFESLVEKLGIPRDPGRNP 2427 Query: 171 VRHVLCLLTN--IH-------------NDAVIPDVGSNIVFGFTRDDAGISLNLIYNLKY 215 + + +L N +H +D+ + ++ F T + + L L Y K Sbjct: 2428 LFDTMFILQNDELHAKTLDQLVYRPYESDSALDVAKFDLSFHLTERETDLFLRLEYCTKL 2487 Query: 216 FTRNFVMQLAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNME-DMTLY 274 F + V ++A + QIL+ N +L + T++ D T+ Sbjct: 2488 FKQQTVERMAHHFLQILRAVTANPENELQEIEMLTAAEKQMLLVAFNDTHREYRADQTIQ 2547 Query: 275 ELFEKQVRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDM 334 +LFE+ + P+H A+ F + +++R+LN +AN+LA VLR +GVG QIV LLVERS +M Sbjct: 2548 QLFEELAEKMPEHTALVFEEKRMSFRELNERANQLAAVLREKGVGPAQIVALLVERSAEM 2607 Query: 335 AGGILGILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDD 394 L LK+G A+LP+D PEER+++++ED+ ++ V++ K+ V+ +DD Sbjct: 2608 VIATLATLKAGGAFLPVDPDYPEERIRYMLEDSQAKLVVTHAHLLHKVSSQS-EVVDVDD 2666 Query: 395 DVLLENESDLDLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDAS 454 ++D +L AY+IYTSGTTG+PKGV++EH+ ++N Sbjct: 2667 PGSYATQTD-NLPCANTPSDLAYIIYTSGTTGKPKGVMLEHKGVANLQAVFAHHLGVTPQ 2725 Query: 455 DRMLQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTL 514 DR S FD + F P++SGAT+ L D + + + IT F+ +P Sbjct: 2726 DRAGHFASISFDASVWDMFGPLLSGATLYVLSRDVINDFQRFAEYVRDNAIT-FLTLPPT 2784 Query: 515 YSALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKR 574 Y+ L +PE+ SLR + AG + L+ K+ + VN YGPTES+V ATL + Sbjct: 2785 YAIYL---EPEQVPSLRTLITAGSASSVALVDKWKE---KVTYVNGYGPTESTVCATLWK 2838 Query: 575 DLKPDDT--ELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRD 632 KPD+ +TIGKPI NT++YIV D L+LKA G +GELCISG LARGY + LT + Sbjct: 2839 -AKPDEPVETITIGKPIQNTKLYIVDDQLQLKAPGQMGELCISGLSLARGYWNRPELTAE 2897 Query: 633 KFVSNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGI 692 KFV NPF +MYRTGDLARW G IE +GR D QVK+RG+R+ELGE+E+ LL Y+ + Sbjct: 2898 KFVDNPFVPGTKMYRTGDLARWLPDGTIEYLGRIDHQVKIRGHRVELGEVESVLLRYDTV 2957 Query: 693 TEAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPT 752 EA ED + +CAY V + + +LR + LP YM+P F QLE+ P+TP Sbjct: 2958 KEAAAITHEDDRGQAYLCAYYVAEGEATPAQLRAYMENELPNYMVPAFFIQLEKMPLTPN 3017 Query: 753 GKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLK 812 K+DR AL + ++ P E+E L IW +VL + +V DNFF LGG S+K Sbjct: 3018 DKIDRKALPKPNQEENRTEQYAAPQTELEQLLAGIWADVLGIKQVGTQDNFFELGGDSIK 3077 Query: 813 ATMLLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQ 872 A + +RL+ + + E+F+ TI A + + ++ E ++ Q Sbjct: 3078 AIQVSTRLNASGWT-LAMKELFQYPTIEEAALRVIPNSRESEQGVVEGE----IALTPIQ 3132 Query: 873 KRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQ 932 K +A + + +N ++ E D G V +Q++ H+ LR + Q Sbjct: 3133 KWFFA--NNFTDRHHWNQAVMLFREDGFDEGLVRQAFQQIVEHHDALRMVYKQEDGAIKQ 3190 Query: 933 VVHDTID-----FSIDYTEEKIDDIRL--EADRFIQPFDLDTSPLFRVKIIKIASRHYLF 985 + D +S D + R+ +D+ DL+ PL V + +L Sbjct: 3191 INRGLTDERFRFYSYDLKNHANSEARILELSDQIQSSIDLEHGPLVHVALFATKDGDHL- 3249 Query: 986 MFDMHHIISDGISIGLFIKELALLYGNA------VLPEPEIQFKDFSVWEKESAENGDFK 1039 + +HH++ DG+S + ++ + Y A VLP+ FKD++ ++ A++ + Sbjct: 3250 LVAIHHLVVDGVSWRILFEDFSSAYSQALHQQEIVLPKKTDSFKDWAAQLQKYADSDELL 3309 Query: 1040 QQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKL 1087 ++ +W + + LP D+ K + F L T L Sbjct: 3310 REVAYWHNL-ETTTTTAALPTDFVTADRKQKHTRTLSFALTVPQTENL 3356 >sp|O30409|TYCC_BREPA Tyrocidine synthetase III [Includes: ATP-dependent asparagine adenylase (AsnA) (Asparagine activase); ATP-dependent glutamine adenylase (GlnA) (Glutamine activase); ATP-dependent tyrosine adenylase (TyrA) (Tyrosine activase); ATP-dependent valine adenylase (ValA) (Valine activase); ATP-dependent ornithine adenylase (OrnA) (Ornithine activase); ATP-dependent leucine adenylase (LeuA) (Leucine activase)] pir||T31076 tyrocidine synthetase 3 - Brevibacillus brevis gb|AAC45930.1| tyrocidine synthetase 3 [Brevibacillus brevis] Length = 6486 Score = 1442 bits (3732), Expect = 0.0, Method: Compositional matrix adjust. Identities = 748/1899 (39%), Positives = 1144/1899 (60%), Gaps = 41/1899 (2%) Query: 12 LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRLDIPDGLFQQLQHLSN 71 T E +++ YWLN G + TD + ++ + L +QL L+ Sbjct: 2260 FQTEEFAEQEAYWLNTFTGEIPVLNLPTDYPRPSVKSFAGDRFVFGSGTALPKQLHQLAQ 2319 Query: 72 RSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEA----YNHYVPIIDTFTT 127 + +LY +LL A L+ K++ I V +P ++ +E+ + + + + + Sbjct: 2320 ETGTTLYMVLLAAYNVLLSKYSRQEDIIVGAPTAGRSHAETESIVGMFVNTLALRNEPAG 2379 Query: 128 GMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN---- 183 G TFR+ L +V+ TLGA++HQDYP D++++ + D + + + +L N+ Sbjct: 2380 GKTFRDFLAEVKINTLGAFEHQDYPLDELVDKLDMQRDLSRNPLFDTVFILQNMEQKPFE 2439 Query: 184 ---------DAVIPDVGSNIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQILKG 234 A + ++ ++A I +L Y+ K F+R + ++A + QIL+ Sbjct: 2440 MEQLTITPYSAEVKQAKFDLSLEAYEENAEIIFSLDYSTKLFSRETIEKIATHFIQILRA 2499 Query: 235 AAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNM-EDMTLYELFEKQVRQTPDHVAVKFN 293 + L + +++ ++ TL LFE+Q ++P AV+ + Sbjct: 2500 VIAEPEMPLSEITMLTEAEKQRLLVDFNGAHKDFPQNKTLQALFEEQAEKSPQATAVEIS 2559 Query: 294 NQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLPLDI 353 Q ++Y++LN +AN+LA LR +GV +Q VG++ RS++M GIL ILK+G AY+P+D Sbjct: 2560 GQPLSYQELNERANQLAATLRERGVQPDQPVGIMANRSVEMVVGILAILKAGGAYVPIDP 2619 Query: 354 KSPEERLQFLIEDAGIEVAVSNKQTEEKLKRD-GLTVIRLDDDVLLE-NESDLDLILGRA 411 + PEER+ +++ D + ++ K KL + LDD+ + S+L I Sbjct: 2620 EYPEERVAYMLTDCQARLVLTQKHLGAKLGSSVTAECLYLDDESNYGVHRSNLQPI--NT 2677 Query: 412 LDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGFLTS 471 AY+IYTSGTTG+PKGV++EHR I N + W+K+EY DR L S+ FD F+ S Sbjct: 2678 ASDLAYIIYTSGTTGKPKGVMVEHRGIVNNVLWKKAEYQMKVGDRSLLSLSFAFDAFVLS 2737 Query: 472 FFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQSLR 531 FFTP++SGATVV ++ EA+DP+++ +LI + T VP+L+ A+L P + + L+ Sbjct: 2738 FFTPVLSGATVVLAEDEEAKDPVSLKKLIAASRCTLMTGVPSLFQAILECSTPADIRPLQ 2797 Query: 532 IVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELTIGKPIGN 591 VTL GEK+T L+ KQL+P + IVNEYGPTESSV+AT +R PD +TIG+PI N Sbjct: 2798 TVTLGGEKITAQLVEKCKQLNPDLVIVNEYGPTESSVVATWQRLAGPD-AAITIGRPIAN 2856 Query: 592 TRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYRTGDL 651 T +YIV +L+ G+VGE+CI G GLARGY + LT +KFVS+PF A ERMY+TGDL Sbjct: 2857 TSLYIVNQYHQLQPIGVVGEICIGGRGLARGYWNKPALTEEKFVSHPFAAGERMYKTGDL 2916 Query: 652 ARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNSRICA 711 +W G IE IGR D QVK+RGYRIE+GEIE+ LL +T AVV ++EDQ S + A Sbjct: 2917 GKWLPDGTIEYIGRIDEQVKVRGYRIEIGEIESALLAAEKLTAAVVVVYEDQLGQSALAA 2976 Query: 712 YIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLKELGA 771 Y D L +L LSK LP YM+P HF QL+Q P+TP GK+D+ AL + A Sbjct: 2977 YFTADEQLDVTKLWSHLSKRLPSYMIPAHFVQLDQLPLTPNGKVDKKALPKPEGKPVTEA 3036 Query: 772 RFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVEIELD 831 ++ PTN +ES+L EIW+ VL V + I DNFF +GGHSLKA + +++H+E+QVE+ L Sbjct: 3037 QYVAPTNAVESKLAEIWERVLGVSGIGILDNFFQIGGHSLKAMAVAAQVHREYQVELPLK 3096 Query: 832 EIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTSYNMP 891 +F + TI LA + + TY I P ++YYP+SSAQKRMY L T YNMP Sbjct: 3097 VLFAQPTIKALAQYVATSGKETYVPIEPAPLQEYYPVSSAQKRMYVLRQFADTGTVYNMP 3156 Query: 892 EVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYTEEKIDD 951 + +EG+LD + E+ + ++ RHE LRTSFH ++ EPVQ VH+ ++ ++ Y E Sbjct: 3157 SALYIEGDLDRKRFEAAIHGLVERHESLRTSFHTVNGEPVQRVHEHVELNVQYAEVTEAQ 3216 Query: 952 IRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLYG 1011 + + F+Q FDL +PL RV + K+A++ +LF+ DMHHIISDG+S G+ ++E + LY Sbjct: 3217 VEPTVESFVQAFDLTKAPLLRVGLFKLAAKRHLFLLDMHHIISDGVSAGIIMEEFSKLYR 3276 Query: 1012 NAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYE 1071 LP + +KDF+VW+ E ++ + + E +WL F G++P+L LP D+ RP+ +S+E Sbjct: 3277 GEELPALSVHYKDFAVWQSELFQSDVYTEHENYWLNAFSGDIPVLNLPADFSRPLTQSFE 3336 Query: 1072 GSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQV 1131 G + F DK L +LA ++ +TL+M+LLA +N++L+K + QEDI+VG+P+ R Sbjct: 3337 GDCVSFQADKALLDDLHKLAQESQSTLFMVLLAAYNVLLAKYSGQEDIVVGTPIAGRSHA 3396 Query: 1132 ELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDT 1191 ++E+V+GMF NTLA+RN+P K F+ FL EVK + L A+ +QDY FE ++ KLDI RD Sbjct: 3397 DIENVLGMFVNTLALRNYPVETKHFQAFLEEVKQNTLQAYAHQDYPFEALVEKLDIQRDL 3456 Query: 1192 GRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYC 1251 RNPLFD M ILQN+ ++ +K+ Y + ++FD+TL E G +H + Y Sbjct: 3457 SRNPLFDTMFILQNLDQKAYELDGLKLEAYPAQAGNAKFDLTLEAHEDETG-IHFALVYS 3515 Query: 1252 TRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQI-LAFNQTSFDLPADQ 1310 T+LF+RE++E M + ++ QV+AD+ + +I ++SE + + + FN T P D Sbjct: 3516 TKLFQRESIERMAGHFLQVLRQVVADQATALREISLLSEEERRIVTVDFNNTFAAYPRDL 3575 Query: 1311 TIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERS 1370 TI LFE+QA + + A+ Q ++Y ELN++ANQLA +LR+ GV S+VGL+ +RS Sbjct: 3576 TIQELFEQQAAKTPEHAAVVMDGQMLTYRELNEKANQLAHVLRQNGVGKESIVGLLADRS 3635 Query: 1371 FEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGE---V 1427 EM+ G +GILK+GGAYL +DP++P ER+ +M+ED G+++VL Q + L GE Sbjct: 3636 LEMITGIMGILKAGGAYLGLDPEHPSERLAYMLEDGGVKVVLVQK---HLLPLVGEGLMP 3692 Query: 1428 IDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLK 1487 I L L D N ++N +SDLAY++YTSG+TGKPKG ++EH+ + L + ++ Sbjct: 3693 IVLEEESLRPEDCGNPAIVNGASDLAYVMYTSGSTGKPKGVMVEHRNVTRLVM-HTNYVQ 3751 Query: 1488 IQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAIL 1547 +++ +R++Q +I FD +I ++L G +L L +K++L D FL +N+IT L Sbjct: 3752 VRESDRMIQTGAIGFDAMTFEIFGALLHGASLYLVSKDVLLDAEKLGDFLRTNQITTMWL 3811 Query: 1548 -PPTY--LANLNPNNIHTVDKMITIGSAISSGLVNEWKRK---CEYINAYGPTETTVYSS 1601 P + L+ NP ++ +I G A+S +N K E N YGPTE T +S+ Sbjct: 3812 TSPLFNQLSQDNPAMFDSLRALIVGGEALSPKHINRVKSALPDLEIWNGYGPTENTTFST 3871 Query: 1602 VWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEM 1661 ++ + E + +PIGKPI N+ YI+D QP+G+PGELC+GG G+ RGY +PE+ Sbjct: 3872 CYLIEQHFE--EQIPIGKPIANSTAYIVDGNNQPQPIGVPGELCVGGDGVARGYVNKPEL 3929 Query: 1662 TADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKI 1721 TA+K + + +YRTGDLARWLPDG +EYLGR+D+QVKIRG+R+E EI+ L + Sbjct: 3930 TAEKFVPNPFAPGETMYRTGDLARWLPDGTIEYLGRIDQQVKIRGYRIELGEIETVLSQQ 3989 Query: 1722 EGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPL 1781 +K+ +V + ++CAY++ ELR+ + +LP +M+PAY+V+ME PL Sbjct: 3990 AQVKEAVVAVIEEANGQKALCAYFVPEQAVDAAELREAMSKQLPGYMVPAYYVQMEKLPL 4049 Query: 1782 TSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGD 1841 T+NGK+D++ LP P S ++ +N+ E L ++W+EVL + +GI DNFFE+GG Sbjct: 4050 TANGKVDRRALPQPSGERTTGSAFVAAQNDTEAKLQQIWQEVLGIPAIGIHDNFFEIGGH 4109 Query: 1842 SLKAMQVAAILGK-HRLHMEIKDLFHRQKIAELSECVRD 1879 SLKAM V + K ++ + +K LF I EL+ + + Sbjct: 4110 SLKAMNVITQVHKTFQVELPLKALFATPTIHELAAHIAE 4148 Score = 1399 bits (3621), Expect = 0.0, Method: Compositional matrix adjust. Identities = 789/2145 (36%), Positives = 1216/2145 (56%), Gaps = 109/2145 (5%) Query: 9 NVLLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQ 67 N L T KK++++WLN + TD P S G L L ++LQ Sbjct: 1220 NELFQTEAYKKQEQHWLNTFADEIPLLNLPTDYPRPSVQSFAGDLVL-FAAGKELLERLQ 1278 Query: 68 HLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIID 123 +++ + +LY ILL A L+ K+T I V +PV + D + + + + + + Sbjct: 1279 QVASETGTTLYMILLAAYNVLLSKYTGQEDIIVGTPVAGRSHADVENIMGIFVNTLALRN 1338 Query: 124 TFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN 183 + TF + L +V++ L AYDHQDYPF++++E + D + + L L N + Sbjct: 1339 QPASSKTFAQFLQEVKQNALAAYDHQDYPFEELVEKLAIQRDISRNPLFDTLFSLENANQ 1398 Query: 184 DAV-IPDVGS------------NIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQ 230 ++ I ++ + ++ + A I L + K F + V ++A+ Y + Sbjct: 1399 QSLAIAELTASPYELFNKISKFDLALNASESPADIQFQLTFATKLFKKETVERMARHYLE 1458 Query: 231 ILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTY-QNMEDMTLYELFEKQVRQTPDHVA 289 IL+ +E + L + T+ + L++L E+Q +TPD VA Sbjct: 1459 ILRWISEQPTASLADIDMMTEAEKRTLLLNVNDTFVERTAATALHQLVEEQAARTPDEVA 1518 Query: 290 VKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYL 349 V + ++TYR+LNA+AN+LAR+LR+ G G + ++G++V+RS M G+L +LK+G AY Sbjct: 1519 VVYEEYALTYRELNARANQLARLLRSHGTGPDTLIGIMVDRSPGMVVGMLAVLKAGGAYT 1578 Query: 350 PLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLEN-ESDLDLIL 408 P+D P ER+Q+++ D+ + ++ + +E G +I +D++ + +++LD + Sbjct: 1579 PIDPSYPPERIQYMLSDSQAPILLTQRHLQELAAYQG-EIIDVDEEAIYTGADTNLDNVA 1637 Query: 409 GRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGF 468 G+ D AYVIYTSG+TG PKGV+I H++I N + W + + D +LQ + FD Sbjct: 1638 GK--DDLAYVIYTSGSTGNPKGVMISHQAICNHMLWMRETFPLTTEDAVLQKTPFSFDAS 1695 Query: 469 LTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQ 528 + F+ P+++G +V RD + +LI KIT VP+L ++ + Sbjct: 1696 VWEFYLPLITGGQLVLAKPDGHRDIAYMTRLIRDEKITTLQMVPSLLDLVMTDPGWSACT 1755 Query: 529 SLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDD-TELTIGK 587 SL+ V GE +TP L+ + +++N YGPTE+++ AT + + + + IGK Sbjct: 1756 SLQRVFCGGEALTPALVSRFYETQQA-QLINLYGPTETTIDATYWPCPRQQEYSAIPIGK 1814 Query: 588 PIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYR 647 PI N R+Y+V + +L+ G+ GELCI+G GLARGY E LT+ FV NPFE MYR Sbjct: 1815 PIDNVRLYVVNASNQLQPVGVAGELCIAGDGLARGYWQREELTKASFVDNPFEPGGTMYR 1874 Query: 648 TGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNS 707 TGD+ R+ G IE +GR D QVK+RG+RIELGEIE LL++ + VV +D + Sbjct: 1875 TGDMVRYLPDGHIEYLGRIDHQVKIRGHRIELGEIEATLLQHEAVKAVVVMARQDGKGQN 1934 Query: 708 RICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLK 767 + AY+V ++ + ELR LS +LP YM+P+ F LEQ P++ GK+DR AL +D Sbjct: 1935 SLYAYVVAEQDIQTAELRTYLSATLPAYMVPSAFVFLEQLPLSANGKVDRKALPQPEDAA 1994 Query: 768 ELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVE 827 A + P NE E++L IW++VL V+ + +HD+FF LGGHSLKA ++S L + FQV+ Sbjct: 1995 ASAAVYVAPRNEWEAKLAAIWESVLGVEPIGVHDHFFELGGHSLKAMHVISLLQRSFQVD 2054 Query: 828 IELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTS 887 + L +FE TI LA L+ + R GTY++I P EK++YYP+S+AQKRM+ L +EG S Sbjct: 2055 VPLKVLFESPTIAGLAPLVAAARKGTYTAIPPVEKQEYYPVSAAQKRMFILQQMEGAGIS 2114 Query: 888 YNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYTEE 947 YNMP M ++G+LD +++ L+ ++ RHE LRTSFH + E VQ VHD +D +I + E Sbjct: 2115 YNMPGFMYLDGKLDTERLQQALKSLVQRHESLRTSFHSVQGETVQRVHDDVDLAISFGEA 2174 Query: 948 KIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELA 1007 + R A++FIQPFDL T+PL R +IK+A +LFM D+HHI+ DG+SIGL I+E A Sbjct: 2175 TEAETRQIAEQFIQPFDLGTAPLLRAGLIKLAPERHLFMLDLHHIVVDGVSIGLLIEEFA 2234 Query: 1008 LLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVH 1067 LY LP IQ+KDF+ W+++ + +F +QE +WL F GE+P+L LP DY RP Sbjct: 2235 QLYHGEELPALRIQYKDFAKWQQDWFQTEEFAEQEAYWLNTFTGEIPVLNLPTDYPRPSV 2294 Query: 1068 KSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTR 1127 KS+ G + F ++L +LA + G TLYM+LLA +N++LSK + QEDIIVG+P Sbjct: 2295 KSFAGDRFVFGSGTALPKQLHQLAQETGTTLYMVLLAAYNVLLSKYSRQEDIIVGAPTAG 2354 Query: 1128 RRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDI 1187 R E ES++GMF NTLA+RN PAG K F+DFL EVK + L AF++QDY +E++ KLD+ Sbjct: 2355 RSHAETESIVGMFVNTLALRNEPAGGKTFRDFLAEVKINTLGAFEHQDYPLDELVDKLDM 2414 Query: 1188 VRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCS 1247 RD RNPLFD + ILQN+ F+ ++ ++ Y E ++FD++L E + + S Sbjct: 2415 QRDLSRNPLFDTVFILQNMEQKPFEMEQLTITPYSAEVKQAKFDLSLEAYEE-NAEIIFS 2473 Query: 1248 FEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILA-FNQTSFDL 1306 +Y T+LF RET+E + + I+ VIA+ E+ +S+I M++E Q++L FN D Sbjct: 2474 LDYSTKLFSRETIEKIATHFIQILRAVIAEPEMPLSEITMLTEAEKQRLLVDFNGAHKDF 2533 Query: 1307 PADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLM 1366 P ++T+ LFEEQA++ A+E Q +SY ELN+RANQLA LRE+GV VG+M Sbjct: 2534 PQNKTLQALFEEQAEKSPQATAVEISGQPLSYQELNERANQLAATLRERGVQPDQPVGIM 2593 Query: 1367 FERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGE 1426 RS EM++G L ILK+GGAY+PIDP+YP ER+ +M+ D +LVLTQ L G Sbjct: 2594 ANRSVEMVVGILAILKAGGAYVPIDPEYPEERVAYMLTDCQARLVLTQKHLGAKL---GS 2650 Query: 1427 VIDLNCAGLNN-----MDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTAS 1481 + C L++ + SNL IN +SDLAY+IYTSGTTGKPKG ++EH+GIVN Sbjct: 2651 SVTAECLYLDDESNYGVHRSNLQPINTASDLAYIIYTSGTTGKPKGVMVEHRGIVNNVLW 2710 Query: 1482 NKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNR 1541 K + +++ +R + S +FD ++ +L G T+ L E D + + ++R Sbjct: 2711 KKAEYQMKVGDRSLLSLSFAFDAFVLSFFTPVLSGATVVLAEDEEAKDPVSLKKLIAASR 2770 Query: 1542 ITAAILPPTYLANL----NPNNIHTVDKMITIGSAISSGLVNEWKR---KCEYINAYGPT 1594 T P+ + P +I + + G I++ LV + K+ +N YGPT Sbjct: 2771 CTLMTGVPSLFQAILECSTPADIRPLQTVTLGGEKITAQLVEKCKQLNPDLVIVNEYGPT 2830 Query: 1595 ETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRG 1654 E++V ++ W + D + IG+PI NT +YI+++Y LQP+G+ GE+CIGG GL RG Sbjct: 2831 ESSVVAT-W--QRLAGPDAAITIGRPIANTSLYIVNQYHQLQPIGVVGEICIGGRGLARG 2887 Query: 1655 YWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEI 1714 YW +P +T +K ++ + ++Y+TGDL +WLPDG +EY+GR+DEQVK+RG+R+E EI Sbjct: 2888 YWNKPALTEEKFVSHPFAAGERMYKTGDLGKWLPDGTIEYIGRIDEQVKVRGYRIEIGEI 2947 Query: 1715 KAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFV 1774 ++ LL E + +V ++QL +++ AY+ + VT+L L +LP +MIPA+FV Sbjct: 2948 ESALLAAEKLTAAVVVVYEDQLGQSALAAYFTADEQLDVTKLWSHLSKRLPSYMIPAHFV 3007 Query: 1775 RMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDN 1834 +++ PLT NGK+D+K LP PE + Y+ P N +E LAE+WE VL + +GI DN Sbjct: 3008 QLDQLPLTPNGKVDKKALPKPEGKPVTEAQYVAPTNAVESKLAEIWERVLGVSGIGILDN 3067 Query: 1835 FFEVGGDSLKAMQVAA-ILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRI 1893 FF++GG SLKAM VAA + ++++ + +K LF + I L++ V Sbjct: 3068 FFQIGGHSLKAMAVAAQVHREYQVELPLKVLFAQPTIKALAQYVA--------------- 3112 Query: 1894 DSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHT 1953 +SG E IE QE S + V + Y++ +A + Sbjct: 3113 -TSGKETYVPIE--------PAPLQEYYPVSSAQKRMYVLRQFADTGTVYNMPSALYIEG 3163 Query: 1954 SIPFRSCGDIGKIQKAILRLVNEQVLLRSVI--VNDGENTYFYEHGSVYNLPFILIDLSG 2011 + D + + AI LV LR+ VN +EH + N+ + + + Sbjct: 3164 DL------DRKRFEAAIHGLVERHESLRTSFHTVNGEPVQRVHEHVEL-NVQYAEVTEAQ 3216 Query: 2012 FDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGI 2071 + S A+ K P L R+ L + A + ++ L H +SDG+S GI Sbjct: 3217 VEPTVESFVQAF---DLTKAP-------LLRVGLFKLAAKRHLFLLDMHHIISDGVSAGI 3266 Query: 2072 ITDQLAAYFAGDSSLPVHSLKH------------------HQNYW 2098 I ++ + + G+ LP S+ + H+NYW Sbjct: 3267 IMEEFSKLYRGE-ELPALSVHYKDFAVWQSELFQSDVYTEHENYW 3310 Score = 1347 bits (3485), Expect = 0.0, Method: Compositional matrix adjust. Identities = 761/2118 (35%), Positives = 1195/2118 (56%), Gaps = 102/2118 (4%) Query: 11 LLSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSAL----GIEGKESLRLDIPDGLFQQL 66 L + + + YWLN G D +L P + EG + + L L Sbjct: 3297 LFQSDVYTEHENYWLNAFSG---DIPVLNLPADFSRPLTQSFEG-DCVSFQADKALLDDL 3352 Query: 67 QHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPII 122 L+ S +L+ +LL A L+ K++ I V +P+ + D + + + + + Sbjct: 3353 HKLAQESQSTLFMVLLAAYNVLLAKYSGQEDIVVGTPIAGRSHADIENVLGMFVNTLALR 3412 Query: 123 DTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIH 182 + F+ L +V++ TL AY HQDYPF+ ++E + D + + + +L N+ Sbjct: 3413 NYPVETKHFQAFLEEVKQNTLQAYAHQDYPFEALVEKLDIQRDLSRNPLFDTMFILQNLD 3472 Query: 183 NDA---------VIPDVGSNIVFGFT----RDDAGISLNLIYNLKYFTRNFVMQLAKQYF 229 A P N F T D+ GI L+Y+ K F R + ++A + Sbjct: 3473 QKAYELDGLKLEAYPAQAGNAKFDLTLEAHEDETGIHFALVYSTKLFQRESIERMAGHFL 3532 Query: 230 QILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNM-EDMTLYELFEKQVRQTPDHV 288 Q+L+ + + L + T+ D+T+ ELFE+Q +TP+H Sbjct: 3533 QVLRQVVADQATALREISLLSEEERRIVTVDFNNTFAAYPRDLTIQELFEQQAAKTPEHA 3592 Query: 289 AVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAY 348 AV + Q +TYR+LN KAN+LA VLR GVG IVGLL +RS++M GI+GILK+G AY Sbjct: 3593 AVVMDGQMLTYRELNEKANQLAHVLRQNGVGKESIVGLLADRSLEMITGIMGILKAGGAY 3652 Query: 349 LPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDLIL 408 L LD + P ERL +++ED G++V + K L +GL I L+++ L + I+ Sbjct: 3653 LGLDPEHPSERLAYMLEDGGVKVVLVQKHLL-PLVGEGLMPIVLEEESLRPEDCGNPAIV 3711 Query: 409 GRALDHPAYVIYTSGTTGQPKGVIIEHRSIS------NTIQWRKSEYSFDASDRMLQLFS 462 A D AYV+YTSG+TG+PKGV++EHR+++ N +Q R+S DRM+Q + Sbjct: 3712 NGASDL-AYVMYTSGSTGKPKGVMVEHRNVTRLVMHTNYVQVRES-------DRMIQTGA 3763 Query: 463 YIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNM 522 FD F ++ GA++ + + D + + ++IT L++ L ++ Sbjct: 3764 IGFDAMTFEIFGALLHGASLYLVSKDVLLDAEKLGDFLRTNQITTMWLTSPLFNQLSQD- 3822 Query: 523 KPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTE 582 P SLR + + GE ++P + K P +EI N YGPTE++ +T + + + Sbjct: 3823 NPAMFDSLRALIVGGEALSPKHINRVKSALPDLEIWNGYGPTENTTFSTCYLIEQHFEEQ 3882 Query: 583 LTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEAN 642 + IGKPI N+ YIV N + + G+ GELC+ G G+ARGY++ LT +KFV NPF Sbjct: 3883 IPIGKPIANSTAYIVDGNNQPQPIGVPGELCVGGDGVARGYVNKPELTAEKFVPNPFAPG 3942 Query: 643 ERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWED 702 E MYRTGDLARW G IE +GR D QVK+RGYRIELGEIE L + + EAVVA+ E+ Sbjct: 3943 ETMYRTGDLARWLPDGTIEYLGRIDQQVKIRGYRIELGEIETVLSQQAQVKEAVVAVIEE 4002 Query: 703 QNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRN 762 N +CAY V ++ + A ELRE++SK LP YM+P ++ Q+E+ P+T GK+DR AL Sbjct: 4003 ANGQKALCAYFVPEQAVDAAELREAMSKQLPGYMVPAYYVQMEKLPLTANGKVDRRALPQ 4062 Query: 763 NQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHK 822 + G+ F N+ E++L +IW+ VL + + IHDNFF +GGHSLKA +++++HK Sbjct: 4063 PSGERTTGSAFVAAQNDTEAKLQQIWQEVLGIPAIGIHDNFFEIGGHSLKAMNVITQVHK 4122 Query: 823 EFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLE 882 FQVE+ L +F TI LAA I + +I P E +YP+S AQKRMY L+ E Sbjct: 4123 TFQVELPLKALFATPTIHELAAHIAESAFEQFETIQPVEPAAFYPVSFAQKRMYILHQFE 4182 Query: 883 GESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSI 942 G SYN+P V+V+EG+LD + + ++ ++ RHE LRTSFH ++ EP+Q VH ++ + Sbjct: 4183 GSGISYNVPSVLVLEGKLDYDRFAAAIQSLVKRHESLRTSFHSVNGEPLQRVHPDVELPV 4242 Query: 943 DYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLF 1002 E D IQPFDL+ +PLFRV +IK+ + +LF DMHHIISDG+S+ + Sbjct: 4243 RLLEATEDQSESLIQELIQPFDLEIAPLFRVNLIKLGAERHLFFMDMHHIISDGVSLAVI 4302 Query: 1003 IKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDY 1062 ++E+A LY L + IQ+KDF+VW+ + A++ F++QE+FW + F GE+PLL LP DY Sbjct: 4303 VEEIASLYAGKQLSDLRIQYKDFAVWQTKLAQSDRFQKQEDFWTRTFAGEIPLLNLPHDY 4362 Query: 1063 KRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVG 1122 RP +S++G + +L++LA + G TL+M+LLA ++++LSK QE+I+VG Sbjct: 4363 PRPSVQSFDGDTVALGTGHHLLEQLRKLAAETGTTLFMVLLAAYHVLLSKYAGQEEIVVG 4422 Query: 1123 SPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMI 1182 +P+ R ++E ++GMF NTLA++N AG+ F+ FL +VK +AL AF++QDY FE ++ Sbjct: 4423 TPIAGRSHADVERIVGMFVNTLALKNTAAGSLSFRAFLEDVKQNALHAFEHQDYPFEHLV 4482 Query: 1183 SKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDG 1242 KL + RD RNPLFD M L + + ++KVS Y +I++FD++L +E DG Sbjct: 4483 EKLQVRRDLSRNPLFDTMFSLGLAESAEGEVADLKVSPYPVNGHIAKFDLSLDAMEKQDG 4542 Query: 1243 LLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQ 1301 LL F YCT+LF +ETV+ + + ++ + AD +I ++ I ++S+ + +L +F Sbjct: 4543 LL-VQFSYCTKLFAKETVDRLAAHYVQLLQTITADPDIELARISVLSKAETEHMLHSFLA 4601 Query: 1302 TSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGS 1361 T P D+T LFEEQ ++ +E A+ F ++ ++Y ELN +ANQLAR+LR KGV S Sbjct: 4602 TKTAYPTDKTFQKLFEEQVEKTPNEIAVLFGNEQLTYQELNAKANQLARVLRRKGVKPES 4661 Query: 1362 VVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWL 1421 VG++ +RS M+IG L +LK+GG ++PIDPDYP ER FM+EDS +L+LT + + Sbjct: 4662 TVGILVDRSLYMVIGMLAVLKAGGTFVPIDPDYPLERQAFMLEDSEAKLLLTLQKMNSQV 4721 Query: 1422 DFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTAS 1481 F E L+ ++ + NL + + ++AY+IYTSGTTGKPKG ++EH+ N+ + Sbjct: 4722 AFPYETFYLDTETVDQEETGNLEHVAQPENVAYIIYTSGTTGKPKGVVIEHRSYANVAFA 4781 Query: 1482 NKEQLKIQDRE-RVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSN 1540 K++ + R++Q +S +FDVS D + ++L GG L + + D + + + Sbjct: 4782 WKDEYHLDSFPVRLLQMASFAFDVSTGDFARALLTGGQLVICPNGVKMDPASLYETIRRH 4841 Query: 1541 RIT------AAILPPTYLANLNPNNIHTVDKMITIGSAISSG-----LVNEWKRKCEYIN 1589 IT A I+P + N ++ + K++ +G+ L+ + +K IN Sbjct: 4842 EITIFEATPALIMPLMHYVYENELDMSQM-KLLILGADSCPAEDFKTLLARFGQKMRIIN 4900 Query: 1590 AYGPTETTVYSSVWIANKQGEV-DDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGG 1648 +YG TE + +S + + VPIGKP+ N MY++D + NLQPVG+ GELCIGG Sbjct: 4901 SYGVTEACIDTSYYEETDVTAIRSGTVPIGKPLPNMTMYVVDAHLNLQPVGVVGELCIGG 4960 Query: 1649 IGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFR 1708 G+ RGY RPE+T +K + + ++YRTGDLA+W DGN+E+LGR D QVKIRG R Sbjct: 4961 AGVARGYLNRPELTEEKFVPNPFAPGERLYRTGDLAKWRADGNVEFLGRNDHQVKIRGVR 5020 Query: 1709 VEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFM 1768 +E EI+ +L K++GI + +V R+++ Q +CAY ++ ELR LL +LP+ M Sbjct: 5021 IELGEIETQLRKLDGITEAVVVAREDRGQEKELCAYVVADHKLDTAELRANLLKELPQAM 5080 Query: 1769 IPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEK 1828 IPAYFV ++A PLT+NGK+D++ LP P+ +M R + Y+ PR+ E LA+VWE+VL + + Sbjct: 5081 IPAYFVTLDALPLTANGKVDRRSLPAPDVTMLRTTEYVAPRSVWEARLAQVWEQVLNVPQ 5140 Query: 1829 VGIEDNFFEVGGDSLKAMQV-AAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVE 1887 VG D+FF +GG SL+AM+V +++ ++++ + ++ LF + I EL+ + + + Sbjct: 5141 VGALDDFFALGGHSLRAMRVLSSMHNEYQVDIPLRILFEKPTIQELAAFIEETAKGNVF- 5199 Query: 1888 NPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMN 1947 SIE ++ Q S + + Y++ + Sbjct: 5200 ---------------SIE--------PVQKQAYYPVSSAQKRMYILDQFEGVGISYNMPS 5236 Query: 1948 AEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRS--VIVNDGENTYFYEHGSVYNLPFI 2005 + + + +++ A RL+ LR+ +VN +E ++PF Sbjct: 5237 TMLIEGKL------ERTRVEAAFQRLIARHESLRTSFAVVNGEPVQNIHE-----DVPFA 5285 Query: 2006 LIDLSGFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSD 2065 L + R + +Q PF+ + L R+ L++ + Y+L H++SD Sbjct: 5286 LAYSEVTEQEARELVSSLVQ------PFDLEVAPLIRVSLLKIGEDRYVLFTDMHHSISD 5339 Query: 2066 GLSLGIITDQLAAYFAGD 2083 G+S GI+ + + GD Sbjct: 5340 GVSSGILLAEWVQLYQGD 5357 Score = 1303 bits (3373), Expect = 0.0, Method: Compositional matrix adjust. Identities = 730/1921 (38%), Positives = 1104/1921 (57%), Gaps = 65/1921 (3%) Query: 11 LLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQHL 69 L + +K++ +W G + D P S +G +++ L L +QL+ L Sbjct: 4332 LAQSDRFQKQEDFWTRTFAGEIPLLNLPHDYPRPSVQSFDG-DTVALGTGHHLLEQLRKL 4390 Query: 70 SNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIIDTF 125 + + +L+ +LL A L+ K+ I V +P+ + D + + + + +T Sbjct: 4391 AAETGTTLFMVLLAAYHVLLSKYAGQEEIVVGTPIAGRSHADVERIVGMFVNTLALKNTA 4450 Query: 126 TTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISD--RDFSF-VRHVLCLLTNIH 182 ++FR L V++ L A++HQDYPF+ ++E +Q D R+ F L L + Sbjct: 4451 AGSLSFRAFLEDVKQNALHAFEHQDYPFEHLVEKLQVRRDLSRNPLFDTMFSLGLAESAE 4510 Query: 183 NDAV------IPDVGSNIVFGFTRD----DAGISLNLIYNLKYFTRNFVMQLAKQYFQIL 232 + P G F + D G+ + Y K F + V +LA Y Q+L Sbjct: 4511 GEVADLKVSPYPVNGHIAKFDLSLDAMEKQDGLLVQFSYCTKLFAKETVDRLAAHYVQLL 4570 Query: 233 KGAAENVSIKLG--SMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQTPDHVAV 290 + + I+L S+ T+T D T +LFE+QV +TP+ +AV Sbjct: 4571 QTITADPDIELARISVLSKAETEHMLHSFLATKTAYPT-DKTFQKLFEEQVEKTPNEIAV 4629 Query: 291 KFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLP 350 F N+ +TY++LNAKAN+LARVLR +GV VG+LV+RS+ M G+L +LK+G ++P Sbjct: 4630 LFGNEQLTYQELNAKANQLARVLRRKGVKPESTVGILVDRSLYMVIGMLAVLKAGGTFVP 4689 Query: 351 LDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDLILGR 410 +D P ER F++ED+ ++ ++ ++ ++ T + V E +L+ + Sbjct: 4690 IDPDYPLERQAFMLEDSEAKLLLTLQKMNSQVAFPYETFYLDTETVDQEETGNLEHVAQP 4749 Query: 411 ALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASD-RMLQLFSYIFDGFL 469 ++ AY+IYTSGTTG+PKGV+IEHRS +N K EY D+ R+LQ+ S+ FD Sbjct: 4750 --ENVAYIIYTSGTTGKPKGVVIEHRSYANVAFAWKDEYHLDSFPVRLLQMASFAFDVST 4807 Query: 470 TSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEE--A 527 F +++G +V DP ++ + I H+IT F A P L L+ + E Sbjct: 4808 GDFARALLTGGQLVICPNGVKMDPASLYETIRRHEITIFEATPALIMPLMHYVYENELDM 4867 Query: 528 QSLRIVTLAGEKVTP---NLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELT 584 ++++ L + L+A + M I+N YG TE+ + + ++T++T Sbjct: 4868 SQMKLLILGADSCPAEDFKTLLA--RFGQKMRIINSYGVTEACIDTSYY-----EETDVT 4920 Query: 585 --------IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVS 636 IGKP+ N +Y+V +L L+ G+VGELCI GAG+ARGYL+ LT +KFV Sbjct: 4921 AIRSGTVPIGKPLPNMTMYVVDAHLNLQPVGVVGELCIGGAGVARGYLNRPELTEEKFVP 4980 Query: 637 NPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAV 696 NPF ER+YRTGDLA+W G +E +GR D QVK+RG RIELGEIE +L + +GITEAV Sbjct: 4981 NPFAPGERLYRTGDLAKWRADGNVEFLGRNDHQVKIRGVRIELGEIETQLRKLDGITEAV 5040 Query: 697 VALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMD 756 V ED+ +CAY+V D L ELR +L K LP+ M+P +F L+ P+T GK+D Sbjct: 5041 VVAREDRGQEKELCAYVVADHKLDTAELRANLLKELPQAMIPAYFVTLDALPLTANGKVD 5100 Query: 757 RNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATML 816 R +L + P + E+RL ++W+ VL V +V D+FF LGGHSL+A + Sbjct: 5101 RRSLPAPDVTMLRTTEYVAPRSVWEARLAQVWEQVLNVPQVGALDDFFALGGHSLRAMRV 5160 Query: 817 LSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMY 876 LS +H E+QV+I L +FEK TI LAA I+ G SI P +K+ YYP+SSAQKRMY Sbjct: 5161 LSSMHNEYQVDIPLRILFEKPTIQELAAFIEETAKGNVFSIEPVQKQAYYPVSSAQKRMY 5220 Query: 877 ALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHD 936 L EG SYNMP M++EG+L+ +VE+ +++I+RHE LRTSF +++ EPVQ +H+ Sbjct: 5221 ILDQFEGVGISYNMPSTMLIEGKLERTRVEAAFQRLIARHESLRTSFAVVNGEPVQNIHE 5280 Query: 937 TIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDG 996 + F++ Y+E + R +QPFDL+ +PL RV ++KI Y+ DMHH ISDG Sbjct: 5281 DVPFALAYSEVTEQEARELVSSLVQPFDLEVAPLIRVSLLKIGEDRYVLFTDMHHSISDG 5340 Query: 997 ISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLL 1056 +S G+ + E LY VLPE IQ+KDF+VW++E +++ F +QE +WL+ F ++P+L Sbjct: 5341 VSSGILLAEWVQLYQGDVLPELRIQYKDFAVWQQEFSQSAAFHKQEAYWLQTFADDIPVL 5400 Query: 1057 ELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQ 1116 LP D+ RP +S+ G + K T L +LA G TLYM+LLA +N++L+K Q Sbjct: 5401 NLPTDFTRPSTQSFAGDQCTIGAGKALTEGLHQLAQATGTTLYMVLLAAYNVLLAKYAGQ 5460 Query: 1117 EDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDY 1176 EDIIVG+P+T R +LE ++GMF NTLAMRN P K F +FL EVK +AL A+ +QDY Sbjct: 5461 EDIIVGTPITGRSHADLEPIVGMFVNTLAMRNKPQREKTFSEFLQEVKQNALDAYGHQDY 5520 Query: 1177 QFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFY--EHEHNISRFDITL 1234 FEE++ KL I RD RNPLFD + QN E ++ + + ++FD+T Sbjct: 5521 PFEELVEKLAIARDLSRNPLFDTVFTFQNSTEEVMTLPECTLAPFMTDETGQHAKFDLTF 5580 Query: 1235 HCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQ 1294 E + + EY T LF RET+E + I ++ + IR+ +I M+ Q Sbjct: 5581 SATEEREEMT-IGVEYSTSLFTRETMERFSRHFLTIAASIVQNPHIRLGEIDMLLPEEKQ 5639 Query: 1295 QILA-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLR 1353 QILA FN T+ D+T+H LFEEQ + D+ AL F +Q+++Y ELN+RAN+LAR+LR Sbjct: 5640 QILAGFNDTAVSYALDKTLHQLFEEQVDKTPDQAALLFSEQSLTYSELNERANRLARVLR 5699 Query: 1354 EKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLT 1413 KGV +V +M ERS EM+IG LGILK+GGAY+P+DP YP ERI++++EDS L+L+ Sbjct: 5700 AKGVGPDRLVAIMAERSPEMVIGILGILKAGGAYVPVDPGYPQERIQYLLEDSNAALLLS 5759 Query: 1414 QNIPYNWLDFDG----EVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTL 1469 Q L E +DLN + GSNLP +N+ +DLAY+IYTSGTTGKPKG + Sbjct: 5760 QAHLLPLLAQVSSELPECLDLNAELDAGLSGSNLPAVNQPTDLAYVIYTSGTTGKPKGVM 5819 Query: 1470 LEHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILND 1529 + H+GIVN +++ ++ +Q S +FD + + +L G T L + D Sbjct: 5820 IPHQGIVNCLQWRRDEYGFGPSDKALQVFSFAFDGFVASLFAPLLGGATCVLPQEAAAKD 5879 Query: 1530 NSCFEAFLNSNRITAAI-LPPTYLANLNPNNIHTVDKMITI---GSAISSGLVNEWKRKC 1585 + + + +T +P + A L+ + +++ + G + LV + K K Sbjct: 5880 PVALKKLMAATEVTHYYGVPSLFQAILDCSTTTDFNQLRCVTLGGEKLPVQLVQKTKEKH 5939 Query: 1586 EYI---NAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPG 1642 I N YGPTE +V +++ ++ E + IG+P+ N Q+YI+D+ +LQP+G+ G Sbjct: 5940 PAIEINNEYGPTENSVVTTI---SRSIEAGQAITIGRPLANVQVYIVDEQHHLQPIGVVG 5996 Query: 1643 ELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQV 1702 ELCIGG GL RGY +PE+TA+K + ++Y+TGDL +W DG +EY+GR DEQV Sbjct: 5997 ELCIGGAGLARGYLNKPELTAEKFVANPFRPGERMYKTGDLVKWRTDGTIEYIGRADEQV 6056 Query: 1703 KIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHAS-ICAYYISAMDYSVTELRKQLL 1761 K+RG+R+E EI++ +L +GI +V R + S +CAY+++A SV+ LR L Sbjct: 6057 KVRGYRIEIGEIESAVLAYQGIDQAVVVARDDDATAGSYLCAYFVAATAVSVSGLRSHLA 6116 Query: 1762 SKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWE 1821 +LP +MIP+YFV ++ PL++NGK+D+K LP P+ S Y+ PRN E LA +W+ Sbjct: 6117 KELPAYMIPSYFVELDQLPLSANGKVDRKALPKPQQSDATTREYVAPRNATEQQLAAIWQ 6176 Query: 1822 EVLRLEKVGIEDNFFEVGGDSLKA-MQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDL 1880 EVL +E +GI D FFE+GG SLKA + +A + ++ + + +F I ++++ + Sbjct: 6177 EVLGVEPIGITDQFFELGGHSLKATLLIAKVYEYMQIELPLNLIFQYPTIEKVADFITHK 6236 Query: 1881 R 1881 R Sbjct: 6237 R 6237 Score = 1212 bits (3137), Expect = 0.0, Method: Compositional matrix adjust. Identities = 684/1858 (36%), Positives = 1064/1858 (57%), Gaps = 85/1858 (4%) Query: 270 DMTLYELFEKQVRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVE 329 D T++EL +Q +TP AV ++TY++L ++ +LA LR +G+ + IV ++ E Sbjct: 463 DKTIFELIAEQASRTPAKAAVVCGEDTLTYQELMERSAQLANALREKGIASGSIVSIMAE 522 Query: 330 RSIDMAGGILGILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTV 389 S+++ I+ +L+SGAAYLP+D + P++R+Q+L++D+ + ++ + ++ G +V Sbjct: 523 HSLELIVAIMAVLRSGAAYLPIDPEYPQDRIQYLLDDSQTTLLLTQSHLQPNIRFAG-SV 581 Query: 390 IRLDDDVLLENESDLDLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEY 449 + LDD L E S D AY+IYTSG+TG PKG +I H+ + N I W Y Sbjct: 582 LYLDDRSLYEGGST-SFAPESKPDDLAYMIYTSGSTGNPKGAMITHQGLVNYIWWANKVY 640 Query: 450 -SFDASDRMLQLFSYI-FDGFLTSFFTPIVSGATV-VFLDETEARDPLAIIQLITLHKIT 506 +A D L+S I FD +TS FTP++SG T+ V+ + + I+ +I +K+ Sbjct: 641 VQGEAVD--FPLYSSISFDLTVTSIFTPLLSGNTIHVYRGADKVQ---VILDIIKDNKVG 695 Query: 507 HFIAVPTLYSALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLH----PGMEIVNEYG 562 PT + L+ ++ +A S+R + GE + L +KQ++ ++I NEYG Sbjct: 696 IIKLTPT-HLKLIEHID-GKASSIRRFIVGGENLPTKL---AKQIYDHFGENVQIFNEYG 750 Query: 563 PTESSVLATLKRDLKPDDT---ELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGL 619 PTE+ V+ + P T + IG P N ++Y++ +++ G +GE+ I+G G+ Sbjct: 751 PTET-VVGCMIYLYDPQTTTQESVPIGVPADNVQLYLLDASMQPVPVGSLGEMYIAGDGV 809 Query: 620 ARGYLHNEVLTRDKFVSNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIEL 679 A+GY + LT++KF+ NPF +MYRTGDLA+W G +E GR D QVK+RG+RIE+ Sbjct: 810 AKGYFNRPELTKEKFIDNPFRPGTKMYRTGDLAKWLPDGNMEYAGRMDYQVKIRGHRIEM 869 Query: 680 GEIENRLLEYNGITEAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPT 739 GEIE RL ++ + EAVV + +D++ + + AY+V +R L+ ELRE L ++LP YM+P+ Sbjct: 870 GEIETRLTQHEAVKEAVVIVEKDESGQNVLYAYLVSERELTVAELREFLGRTLPSYMIPS 929 Query: 740 HFFQLEQFPMTPTGKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSI 799 F +L + P+T GK++R L G + P NEIE++L EIW+ VL + +V I Sbjct: 930 FFIRLAEIPLTANGKVERKKLPKPAGAVVTGTAYAAPQNEIEAKLAEIWQQVLGISQVGI 989 Query: 800 HDNFFMLGGHSLKATMLLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILP 859 HD+FF LGGHSLKA ++ ++ K +VE+ + +FE T+ LA + Y++I P Sbjct: 990 HDDFFDLGGHSLKAMTVVFQVSKALEVELPVKALFEHPTVAELARFLSRSEKTEYTAIQP 1049 Query: 860 TEKRDYYPMSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEIL 919 +++YP+SSAQKRMY L EG SYN+ +++EG+LD + S ++Q+ RHE L Sbjct: 1050 VAAQEFYPVSSAQKRMYILQQFEGNGISYNISGAILLEGKLDYARFASAVQQLAERHEAL 1109 Query: 920 RTSFHMIHHEPVQVVHDTID---FSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKII 976 RTSFH I EPVQ VH+ ++ F ++ E++ + I E F++PFDL +PL R ++ Sbjct: 1110 RTSFHRIDGEPVQKVHEEVEVPLFMLEAPEDQAEKIMRE---FVRPFDLGVAPLMRTGLL 1166 Query: 977 KIASRHYLFMFDMHHIISDGISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENG 1036 K+ +LF+ DMHHIISDG+S + ++E A LY A L +Q+KDF+ W+ E + Sbjct: 1167 KLGKDRHLFLLDMHHIISDGVSSQILLREFAELYQGADLQPLSLQYKDFAAWQNELFQTE 1226 Query: 1037 DFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGA 1096 +K+QE+ WL F E+PLL LP DY RP +S+ G + F KE +L+++A + G Sbjct: 1227 AYKKQEQHWLNTFADEIPLLNLPTDYPRPSVQSFAGDLVLFAAGKELLERLQQVASETGT 1286 Query: 1097 TLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRF 1156 TLYM+LLA +N++LSK T QEDIIVG+PV R ++E++MG+F NTLA+RN PA +K F Sbjct: 1287 TLYMILLAAYNVLLSKYTGQEDIIVGTPVAGRSHADVENIMGIFVNTLALRNQPASSKTF 1346 Query: 1157 KDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEM 1216 FL EVK +AL+A+D+QDY FEE++ KL I RD RNPLFD + L+N E+ Sbjct: 1347 AQFLQEVKQNALAAYDHQDYPFEELVEKLAIQRDISRNPLFDTLFSLENANQQSLAIAEL 1406 Query: 1217 KVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIA 1276 S YE + IS+FD+ L+ E + + T+LFK+ETVE M + I+ + Sbjct: 1407 TASPYELFNKISKFDLALNASES-PADIQFQLTFATKLFKKETVERMARHYLEILRWISE 1465 Query: 1277 DREIRISDICMVSENAVQQILA-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQT 1335 ++DI M++E + +L N T + A +H L EEQA R DE A+ + + Sbjct: 1466 QPTASLADIDMMTEAEKRTLLLNVNDTFVERTAATALHQLVEEQAARTPDEVAVVYEEYA 1525 Query: 1336 MSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYP 1395 ++Y ELN RANQLARLLR G +++G+M +RS M++G L +LK+GGAY PIDP YP Sbjct: 1526 LTYRELNARANQLARLLRSHGTGPDTLIGIMVDRSPGMVVGMLAVLKAGGAYTPIDPSYP 1585 Query: 1396 GERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYM 1455 ERI++M+ DS ++LTQ + GE+ID++ + +NL + DLAY+ Sbjct: 1586 PERIQYMLSDSQAPILLTQRHLQELAAYQGEIIDVDEEAIYTGADTNLDNVAGKDDLAYV 1645 Query: 1456 IYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILL 1515 IYTSG+TG PKG ++ H+ I N +E + + V+Q + SFD S+ + + ++ Sbjct: 1646 IYTSGSTGNPKGVMISHQAICNHMLWMRETFPLTTEDAVLQKTPFSFDASVWEFYLPLIT 1705 Query: 1516 GGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTY--LANLNP--NNIHTVDKMITIGS 1571 GG L L + D + + +IT + P+ L +P + ++ ++ G Sbjct: 1706 GGQLVLAKPDGHRDIAYMTRLIRDEKITTLQMVPSLLDLVMTDPGWSACTSLQRVFCGGE 1765 Query: 1572 AISSGLVNEW--KRKCEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYIL 1629 A++ LV+ + ++ + IN YGPTETT+ ++ W +Q E +PIGKPI N ++Y++ Sbjct: 1766 ALTPALVSRFYETQQAQLINLYGPTETTIDATYWPCPRQQEY-SAIPIGKPIDNVRLYVV 1824 Query: 1630 DKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPD 1689 + LQPVG+ GELCI G GL RGYW+R E+T + G +YRTGD+ R+LPD Sbjct: 1825 NASNQLQPVGVAGELCIAGDGLARGYWQREELTKASFVDNPFEPGGTMYRTGDMVRYLPD 1884 Query: 1690 GNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAM 1749 G++EYLGR+D QVKIRG R+E EI+A LL+ E +K V+V R++ S+ AY ++ Sbjct: 1885 GHIEYLGRIDHQVKIRGHRIELGEIEATLLQHEAVKAVVVMARQDGKGQNSLYAYVVAEQ 1944 Query: 1750 DYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPR 1809 D ELR L + LP +M+P+ FV +E PL++NGK+D+K LP PE++ + Y+ PR Sbjct: 1945 DIQTAELRTYLSATLPAYMVPSAFVFLEQLPLSANGKVDRKALPQPEDAAASAAVYVAPR 2004 Query: 1810 NEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGKH-RLHMEIKDLFHRQ 1868 NE E LA +WE VL +E +G+ D+FFE+GG SLKAM V ++L + ++ + +K LF Sbjct: 2005 NEWEAKLAAIWESVLGVEPIGVHDHFFELGGHSLKAMHVISLLQRSFQVDVPLKVLFESP 2064 Query: 1869 KIAELSECVRDLRNNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRN 1928 IA L+ V R P ++ QE + + Sbjct: 2065 TIAGLAPLVAAARKGTYTAIP------------------------PVEKQEYYPVSAAQK 2100 Query: 1929 APLVGKHLPAAVQKYHLMNAEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRSVIVNDG 1988 + + + A Y++ + + D ++Q+A+ LV LR+ + Sbjct: 2101 RMFILQQMEGAGISYNMPGFMYLDGKL------DTERLQQALKSLVQRHESLRTSFHSVQ 2154 Query: 1989 ENTYFYEHGSVYNLPFILIDLS-GFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQ 2047 T H V DL+ F A +E + PF+ L R L++ Sbjct: 2155 GETVQRVHDDV--------DLAISFGEATEAETRQIAEQFIQ--PFDLGTAPLLRAGLIK 2204 Query: 2048 TAPEDYMLLYSADHAVSDGLSLGIITDQLAAYFAGDSSLPVHSLKHHQNYWDYADQMQ 2105 APE ++ + H V DG+S+G++ ++ A + G+ LP ++ Y D+A Q Sbjct: 2205 LAPERHLFMLDLHHIVVDGVSIGLLIEEFAQLYHGE-ELPALRIQ----YKDFAKWQQ 2257 Score = 520 bits (1340), Expect = e-145, Method: Compositional matrix adjust. Identities = 333/1041 (31%), Positives = 556/1041 (53%), Gaps = 50/1041 (4%) Query: 866 YPMSSAQKRMYALYH--LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSF 923 YP++ Q+ M L+H + S++Y + +EG+ + E L +++ +E+LRT+F Sbjct: 11 YPLTPLQEGM--LFHAVTDTGSSAYCLQMSATIEGDFHLPLFEKSLNKLVENYEVLRTAF 68 Query: 924 -HMIHHEPVQVVHDTIDFSIDYTEEKIDDI-RLEADRFIQP-------FDLDTSPLFRVK 974 + P QVV ++ E I + E D +IQ FDL L + Sbjct: 69 VYQNMQRPRQVVFKERKVTVPC--ENIAHLPSAEQDAYIQAYTKQHHAFDLTKDNLMKAA 126 Query: 975 IIKIASRHYLFMFDMHHIISDGISIGLFIKEL-----ALLYGNAVLPEPEIQFKDFSVWE 1029 I + A Y ++ HHII DG ++G+ + +L AL G + E + ++ W Sbjct: 127 IFQTAENKYRLVWAFHHIIVDGWTLGVLLHKLLTYYAALRKGEPIPREATKPYSEYIKWL 186 Query: 1030 KESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKE 1089 + +N D + +W G P YE + FT+ E T++L + Sbjct: 187 DK--QNKD--EALAYWQNYLAGYDHQAAFPKKKLGTEASRYEHVEAMFTIAPEKTQQLIQ 242 Query: 1090 LAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVT-RRRQVE-LESVMGMFSNTLAMR 1147 +A N AT+ + AL+ I+ S N +D++ GS V+ R Q++ +ES++G+F NT+ R Sbjct: 243 IANQNQATMSSVFQALWGILASTYKNADDVVFGSVVSGRPPQIQGIESMVGLFINTIPTR 302 Query: 1148 NFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEM--ISKLDIVRDTGRNPLFDAMLILQN 1205 + F + L V+ AL+ + Y F + I +++ L D ++ +N Sbjct: 303 VQTNKQQTFSELLQTVQKQALA---SATYDFAPLYEIQSTTVLKQE----LIDHLVTFEN 355 Query: 1206 IAVNQFQFGEMKVSF---YEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVET 1262 + + E + F E + +D+ + L+ Y +++ V Sbjct: 356 YPDHSMKHLEESLGFQFTVESGDEQTSYDLNVVVALAPSNELYVKLSYNAAVYESSFVNR 415 Query: 1263 MIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLPADQTIHGLFEEQAK 1321 + +L+ +++QVI + + + +I +++E QQ+L A+N T+ + P D+TI L EQA Sbjct: 416 IEGHLRTVIDQVIGNPHVHLHEIGIITEEEKQQLLVAYNDTAAEYPRDKTIFELIAEQAS 475 Query: 1322 RRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGIL 1381 R + A+ + T++Y EL +R+ QLA LREKG+ +GS+V +M E S E+++ + +L Sbjct: 476 RTPAKAAVVCGEDTLTYQELMERSAQLANALREKGIASGSIVSIMAEHSLELIVAIMAVL 535 Query: 1382 KSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGS 1441 +SG AYLPIDP+YP +RI+++++DS L+LTQ+ + F G V+ L+ L + Sbjct: 536 RSGAAYLPIDPEYPQDRIQYLLDDSQTTLLLTQSHLQPNIRFAGSVLYLDDRSLYEGGST 595 Query: 1442 NLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVN-LTASNKEQLKIQDRERVVQFSSI 1500 + ++ DLAYMIYTSG+TG PKG ++ H+G+VN + +NK ++ + + + +SSI Sbjct: 596 SFAPESKPDDLAYMIYTSGSTGNPKGAMITHQGLVNYIWWANKVYVQGEAVDFPL-YSSI 654 Query: 1501 SFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYLANLN--PN 1558 SFD+++ I +L G T+ + + + N++ L PT+L + Sbjct: 655 SFDLTVTSIFTPLLSGNTIHVYRGA--DKVQVILDIIKDNKVGIIKLTPTHLKLIEHIDG 712 Query: 1559 NIHTVDKMITIGSAISSGLVNE----WKRKCEYINAYGPTETTVYSSVWIANKQGEVDDP 1614 ++ + I G + + L + + + N YGPTET V +++ + Q + Sbjct: 713 KASSIRRFIVGGENLPTKLAKQIYDHFGENVQIFNEYGPTETVVGCMIYLYDPQTTTQES 772 Query: 1615 VPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRI 1674 VPIG P N Q+Y+LD PVG GE+ I G G+ +GY+ RPE+T +K I Sbjct: 773 VPIGVPADNVQLYLLDASMQPVPVGSLGEMYIAGDGVAKGYFNRPELTKEKFIDNPFRPG 832 Query: 1675 GKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKN 1734 K+YRTGDLA+WLPDGN+EY GRMD QVKIRG R+E EI+ L + E +K+ +V K+ Sbjct: 833 TKMYRTGDLAKWLPDGNMEYAGRMDYQVKIRGHRIEMGEIETRLTQHEAVKEAVVIVEKD 892 Query: 1735 QLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPV 1794 + + AY +S + +V ELR+ L LP +MIP++F+R+ PLT+NGK+++K LP Sbjct: 893 ESGQNVLYAYLVSERELTVAELREFLGRTLPSYMIPSFFIRLAEIPLTANGKVERKKLPK 952 Query: 1795 PENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGK 1854 P ++ + Y P+NEIE LAE+W++VL + +VGI D+FF++GG SLKAM V + K Sbjct: 953 PAGAVVTGTAYAAPQNEIEAKLAEIWQQVLGISQVGIHDDFFDLGGHSLKAMTVVFQVSK 1012 Query: 1855 H-RLHMEIKDLFHRQKIAELS 1874 + + +K LF +AEL+ Sbjct: 1013 ALEVELPVKALFEHPTVAELA 1033 >pir||JX0340 gramicidin S synthase 2 - Bacillus brevis dbj|BAA06146.1| gramicidin S synthetase 2 [Brevibacillus brevis] Length = 4450 Score = 1364 bits (3530), Expect = 0.0, Method: Compositional matrix adjust. Identities = 795/2153 (36%), Positives = 1232/2153 (57%), Gaps = 117/2153 (5%) Query: 9 NVLLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDG--LFQQ 65 N LL + ++K++ YWLN + TD P + +GK R G L Sbjct: 1226 NRLLQSDVIEKQEAYWLNVFTEEIPVLNLPTDYPRPTIQSFDGK---RFTFSTGKQLMDD 1282 Query: 66 LQHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPI 121 L ++ + +LY +LL A + K++ I V +P+ + D + + + + I Sbjct: 1283 LYKVATETGTTLYMVLLAAYNVFLSKYSGQDDIVVGTPIAGRSHADVENMLGMFVNTLAI 1342 Query: 122 IDTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTN- 180 TF++ L V++T L AY++ DYPFD ++E + D + + + +L N Sbjct: 1343 RSRLNNEDTFKDFLANVKQTALHAYENPDYPFDTLVEKLGIQRDLSRNPLFDTMFVLQNT 1402 Query: 181 ------IHNDAVIPDVGS------NIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQY 228 + + P V + ++ + + I L L Y K FT V ++A + Sbjct: 1403 DRKSFEVEQITITPYVPNSRHSKFDLTLEVSEEQNEILLCLEYCTKLFTDKTVERMAGHF 1462 Query: 229 FQILKGAAENVSIKLGSMXXXXXXXXXXXXXX---QTRTYQNMEDMTLYELFEKQVRQTP 285 QIL N +I + + TY +M+ T+ LFE+QV +TP Sbjct: 1463 LQILHAIVGNPTIIISEIEILSEEEKQHILFEFNDTKTTYPHMQ--TIQGLFEEQVEKTP 1520 Query: 286 DHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSG 345 DHVAV + +Q++TYR+LN +AN++ARVLR +GV + IVGLLVERS +M GI+GILK+G Sbjct: 1521 DHVAVGWKDQALTYRELNERANQVARVLRQKGVQPDNIVGLLVERSPEMLVGIMGILKAG 1580 Query: 346 AAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLD 405 AYLPLD + P +R+ ++I+D G+ + ++ +Q L D + LD+D L + +S Sbjct: 1581 GAYLPLDPEYPADRISYMIQDCGVRIMLT-QQHLLSLVHDEFDCVILDEDSLYKGDSSNL 1639 Query: 406 LILGRALDHPAYVIYTSGTTGQPKGVIIEHRSI------SNTIQWRKSEYSFDASDRMLQ 459 + +A D AY++YTSG+TG+PKGV++EHR++ +N +Q R+ DR++Q Sbjct: 1640 APVNQAGDL-AYIMYTSGSTGKPKGVMVEHRNVIRLVKNTNYVQVRED-------DRIIQ 1691 Query: 460 LFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALL 519 + FD F ++ GA + + + D + + + ++IT L++ L Sbjct: 1692 TGAIGFDALTFEVFGSLLHGAELYPVTKDVLLDAEKLHKFLQANQITIMWLTSPLFNQLS 1751 Query: 520 RNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPD 579 + + E LR + + G+ ++P + K+ P + + N YGPTE++ +T K Sbjct: 1752 QGTE-EMFAGLRSLIVGGDALSPKHINNVKRKCPNLTMWNGYGPTENTTFSTCFLIDKEY 1810 Query: 580 DTELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPF 639 D + IGK I N+ VYI+ +L+ G+ GELC+ G G+ARGY++ LT +KFV NPF Sbjct: 1811 DDNIPIGKAISNSTVYIMDRYGQLQPVGVPGELCVGGDGVARGYMNQPALTEEKFVPNPF 1870 Query: 640 EANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVAL 699 ERMYRTGDLARW G IE +GR D QVK+RGYRIE GEIE L+++ + E+V+ + Sbjct: 1871 APGERMYRTGDLARWLPDGTIEYLGRIDQQVKIRGYRIEPGEIETLLVKHKKVKESVIMV 1930 Query: 700 WEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNA 759 ED N +CAY V + ++ ELRE ++K LP YM+P +F Q+EQ P+T GK++R+A Sbjct: 1931 VEDNNGQKALCAYYVPEEEVTVSELREYIAKELPVYMVPAYFVQIEQMPLTQNGKVNRSA 1990 Query: 760 LRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSR 819 L + P+++IE +L EIW NVL V+K+ + DNFF LGGHSL+A ++S+ Sbjct: 1991 LPKPDGEFGTATEYVAPSSDIEMKLAEIWHNVLGVNKIGVLDNFFELGGHSLRAMTMISQ 2050 Query: 820 LHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALY 879 +HKEF VE+ L +FE TI LA I G Y +I P +DYYP+SSAQKRMY LY Sbjct: 2051 VHKEFDVELPLKVLFETPTISALAQYIADGEKGMYLAIQPVTPQDYYPVSSAQKRMYILY 2110 Query: 880 HLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTID 939 EG +YN+P VM +EG+LD + E ++ +I+RHE LRTSF+ ++ EPVQ VH ++ Sbjct: 2111 EFEGAGITYNVPNVMFIEGKLDYQRFEYAIKSLINRHEALRTSFYSLNGEPVQRVHQNVE 2170 Query: 940 FSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISI 999 I Y+E K D+I + F+QPFDL+ +P RV ++K+AS +LF+ DMHHIISDG+S+ Sbjct: 2171 LQIAYSEAKEDEIEQIVESFVQPFDLEIAPALRVGLVKLASDRHLFLMDMHHIISDGVSM 2230 Query: 1000 GLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELP 1059 + KE+A LY L E IQ+KDF+VW+ E ++ ++Q+ +WL F ++P+L L Sbjct: 2231 QIITKEIADLYKGKELAELHIQYKDFAVWQNEWFQSAALEKQKTYWLNTFAEDIPVLNLS 2290 Query: 1060 VDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDI 1119 DY RP +S+EG + F+ K+ +LK LA + G TLYMLLLA +N++L K + QE+I Sbjct: 2291 TDYPRPTIQSFEGDIVTFSAGKQLAEELKRLATETGTTLYMLLLAAYNVLLHKYSGQEEI 2350 Query: 1120 IVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFE 1179 +VG+P+ R ++E+++GMF NTLA++N P + F +FL EVK +AL AF+NQDY FE Sbjct: 2351 VVGTPIAGRSHADVENIVGMFVNTLALKNTPIAVRTFHEFLLEVKQNALEAFENQDYPFE 2410 Query: 1180 EMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSF--YEHEHNISRFDITLHCL 1237 +I KL + RD RNPLFD M L NI Q + G +SF YE ++ I++FDI+ L Sbjct: 2411 NLIEKLQVRRDLSRNPLFDTMFSLSNID-EQVEIGIEGLSFSPYEMQYWIAKFDISFDIL 2469 Query: 1238 EGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL 1297 E D + F YCT LFK+ET+E + + I+ +++ + EI++ +I M+SE Q++L Sbjct: 2470 EKQDDI-QFYFNYCTNLFKKETIERLATHFMHILQEIVINPEIKLCEINMLSEEEQQRVL 2528 Query: 1298 A-FNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKG 1356 FN T ++ H LFEEQ ++ D A+ + +SY ELN +ANQLAR+LR+KG Sbjct: 2529 YDFNGTDATYATNKIFHELFEEQVEKTPDHIAVIDEREKLSYQELNAKANQLARVLRQKG 2588 Query: 1357 VTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNI 1416 V S+VG+M +RS +M++G LG+LK+GGAY+PID DYP ERI +M+EDSG L+LTQ Sbjct: 2589 VQPNSMVGIMVDRSLDMIVGMLGVLKAGGAYVPIDIDYPQERISYMMEDSGAALLLTQQK 2648 Query: 1417 PYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIV 1476 + F G+++ L+ + + SNL I R D+AY+IYTSGTTGKPKG ++EH+ V Sbjct: 2649 LTQQIAFSGDILYLDQEEWLHEEASNLEPIARPQDIAYIIYTSGTTGKPKGVMIEHQSYV 2708 Query: 1477 NLTASNKEQLKIQDRE-RVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEA 1535 N+ + K+ ++ R++Q +S +FDVS D + ++L GG L + E+ D + A Sbjct: 2709 NVAMAWKDAYRLDTFPVRLLQMASFAFDVSAGDFARALLTGGQLIVCPNEVKMDPASLYA 2768 Query: 1536 FLNSNRIT------AAILP---PTYLANLNPNNIHTVDKMITIGSAISS-----GLVNEW 1581 + IT A ++P Y L+ + + +++ +GS S LV+ + Sbjct: 2769 IIKKYDITIFEATPALVIPLMEYIYEQKLDISQL----QILIVGSDSCSMEDFKTLVSRF 2824 Query: 1582 KRKCEYINAYGPTETTVYSSVWIANKQG-EVDDPVPIGKPILNTQMYILDKYRNLQPVGI 1640 +N+YG TE + SS + V VPIGKP N +MYI+++Y +QPVG+ Sbjct: 2825 GSTIRIVNSYGVTEACIDSSYYEQPLSSLHVTGTVPIGKPYANMKMYIMNQYLQIQPVGV 2884 Query: 1641 PGELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDE 1700 GELCIGG G+ RGY RP++TA+K + K+YRTGDLARW+PDGN+E+LGR D Sbjct: 2885 IGELCIGGAGVARGYLNRPDLTAEKFVPNPFVPGEKLYRTGDLARWMPDGNVEFLGRNDH 2944 Query: 1701 QVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQL 1760 QVKIRG R+E EI+A+L K + IK+ V R++ ++ +CAY ++ + +V ELR L Sbjct: 2945 QVKIRGIRIELGEIEAQLRKHDSIKEATVIAREDHMKEKYLCAYMVTEGEVNVAELRAYL 3004 Query: 1761 LSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVW 1820 + LP MIP+YFV +EA PLT+NGKID++ LP P+ S+ + Y+ PR +E L E+W Sbjct: 3005 ATDLPAAMIPSYFVSLEAMPLTANGKIDKRSLPEPDGSISIGTEYVAPRTMLEGKLEEIW 3064 Query: 1821 EEVLRLEKVGIEDNFFEVGGDSLKAMQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDL 1880 ++VL L++VGI D+FF +GG SLKAM V + + H++ E+ +R L Sbjct: 3065 KDVLGLQRVGIHDDFFTIGGHSLKAMAVISQV-------------HKECQTEVP--LRVL 3109 Query: 1881 RNNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAV 1940 P ++ I+ + TE +I+ + Q+ S + + Sbjct: 3110 FETPTIQGLAKYIEETDTEQYMAIQ--------PVSGQDYYPVSSAQKRMFIVNQFDGVG 3161 Query: 1941 QKYHLMNAEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRSV--IVNDGENTYFYEHGS 1998 Y++ + + + + +++ A RL+ LR+ I+N +E Sbjct: 3162 ISYNMPSIMLIEGKL------ERTRLESAFKRLIERHESLRTSFEIINGKPVQKIHEEAD 3215 Query: 1999 VYNLPFILIDLSGFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYS 2058 +N+ + +E + + D F + PF+ L R+ L++ + ++L++ Sbjct: 3216 -FNMSY---------QVASNEQVEKMIDEFIQ-PFDLSVAPLLRVELLKLEEDRHVLIFD 3264 Query: 2059 ADHAVSDGLSLGIITDQLAAYFAGDSSLPVHSLKHH-----QNYWDYADQMQK 2106 H +SDG+S I+ +L + G+ +LP +++ QN W ++ +K Sbjct: 3265 MHHIISDGISSNILMKELGELYQGN-ALPELRIQYKDFAVWQNEWFQSEAFKK 3316 Score = 1339 bits (3465), Expect = 0.0, Method: Compositional matrix adjust. Identities = 745/1928 (38%), Positives = 1134/1928 (58%), Gaps = 61/1928 (3%) Query: 9 NVLLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQ 67 N ++ ++K+K YWLN + TD P + EG + + L ++L+ Sbjct: 2261 NEWFQSAALEKQKTYWLNTFAEDIPVLNLSTDYPRPTIQSFEG-DIVTFSAGKQLAEELK 2319 Query: 68 HLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIID 123 L+ + +LY +LL A L+ K++ I V +P+ + D + + + + + + Sbjct: 2320 RLATETGTTLYMLLLAAYNVLLHKYSGQEEIVVGTPIAGRSHADVENIVGMFVNTLALKN 2379 Query: 124 TFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN 183 T TF E LL+V++ L A+++QDYPF+ +IE +Q D + + + L+NI Sbjct: 2380 TPIAVRTFHEFLLEVKQNALEAFENQDYPFENLIEKLQVRRDLSRNPLFDTMFSLSNIDE 2439 Query: 184 DAVIPDVG--------------SNIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYF 229 I G +I F I Y F + + +LA + Sbjct: 2440 QVEIGIEGLSFSPYEMQYWIAKFDISFDILEKQDDIQFYFNYCTNLFKKETIERLATHFM 2499 Query: 230 QILKGAAENVSIKLGSMXXXXXXXXXXXXXX---QTRTYQNMEDMTLYELFEKQVRQTPD 286 IL+ N IKL + TY + +ELFE+QV +TPD Sbjct: 2500 HILQEIVINPEIKLCEINMLSEEEQQRVLYDFNGTDATYAT--NKIFHELFEEQVEKTPD 2557 Query: 287 HVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGA 346 H+AV + ++Y++LNAKAN+LARVLR +GV N +VG++V+RS+DM G+LG+LK+G Sbjct: 2558 HIAVIDEREKLSYQELNAKANQLARVLRQKGVQPNSMVGIMVDRSLDMIVGMLGVLKAGG 2617 Query: 347 AYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDL 406 AY+P+DI P+ER+ +++ED+G + ++ ++ +++ G ++ LD + L E+ Sbjct: 2618 AYVPIDIDYPQERISYMMEDSGAALLLTQQKLTQQIAFSG-DILYLDQEEWLHEEASNLE 2676 Query: 407 ILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASD-RMLQLFSYIF 465 + R D AY+IYTSGTTG+PKGV+IEH+S N K Y D R+LQ+ S+ F Sbjct: 2677 PIARPQD-IAYIIYTSGTTGKPKGVMIEHQSYVNVAMAWKDAYRLDTFPVRLLQMASFAF 2735 Query: 466 DGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPE 525 D F +++G ++ DP ++ +I + IT F A P L L+ + + Sbjct: 2736 DVSAGDFARALLTGGQLIVCPNEVKMDPASLYAIIKKYDITIFEATPALVIPLMEYIYEQ 2795 Query: 526 --EAQSLRIVTLAGEKVT-PNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDT- 581 + L+I+ + + + + + + IVN YG TE+ + ++ +P + Sbjct: 2796 KLDISQLQILIVGSDSCSMEDFKTLVSRFGSTIRIVNSYGVTEACIDSSYYE--QPLSSL 2853 Query: 582 ----ELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSN 637 + IGKP N ++YI+ L+++ G++GELCI GAG+ARGYL+ LT +KFV N Sbjct: 2854 HVTGTVPIGKPYANMKMYIMNQYLQIQPVGVIGELCIGGAGVARGYLNRPDLTAEKFVPN 2913 Query: 638 PFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVV 697 PF E++YRTGDLARW G +E +GR D QVK+RG RIELGEIE +L +++ I EA V Sbjct: 2914 PFVPGEKLYRTGDLARWMPDGNVEFLGRNDHQVKIRGIRIELGEIEAQLRKHDSIKEATV 2973 Query: 698 ALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDR 757 ED +CAY+V + ++ ELR L+ LP M+P++F LE P+T GK+D+ Sbjct: 2974 IAREDHMKEKYLCAYMVTEGEVNVAELRAYLATDLPAAMIPSYFVSLEAMPLTANGKIDK 3033 Query: 758 NALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLL 817 +L +G + P +E +L EIWK+VL + +V IHD+FF +GGHSLKA ++ Sbjct: 3034 RSLPEPDGSISIGTEYVAPRTMLEGKLEEIWKDVLGLQRVGIHDDFFTIGGHSLKAMAVI 3093 Query: 818 SRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYA 877 S++HKE Q E+ L +FE TI LA I+ Y +I P +DYYP+SSAQKRM+ Sbjct: 3094 SQVHKECQTEVPLRVLFETPTIQGLAKYIEETDTEQYMAIQPVSGQDYYPVSSAQKRMFI 3153 Query: 878 LYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDT 937 + +G SYNMP +M++EG+L+ ++ES +++I RHE LRTSF +I+ +PVQ +H+ Sbjct: 3154 VNQFDGVGISYNMPSIMLIEGKLERTRLESAFKRLIERHESLRTSFEIINGKPVQKIHEE 3213 Query: 938 IDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGI 997 DF++ Y + + D FIQPFDL +PL RV+++K+ ++ +FDMHHIISDGI Sbjct: 3214 ADFNMSYQVASNEQVEKMIDEFIQPFDLSVAPLLRVELLKLEEDRHVLIFDMHHIISDGI 3273 Query: 998 SIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLE 1057 S + +KEL LY LPE IQ+KDF+VW+ E ++ FK+QEE+W+ +F E P+L+ Sbjct: 3274 SSNILMKELGELYQGNALPELRIQYKDFAVWQNEWFQSEAFKKQEEYWVNVFADERPILD 3333 Query: 1058 LPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQE 1117 +P DY RP+ +S++G+++ F K+ L +A + G TLYM+LLA +N++LSK + QE Sbjct: 3334 IPTDYPRPMQQSFDGAQLTFGTGKQLMDGLYRVATETGTTLYMVLLAAYNVLLSKYSGQE 3393 Query: 1118 DIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQ 1177 DIIVG+P+ R +LE+++GMF NTLAMRN P G K FK F++E+K +AL+AF+NQDY Sbjct: 3394 DIIVGTPIVGRSHTDLENIVGMFVNTLAMRNKPEGEKTFKAFVSEIKQNALAAFENQDYP 3453 Query: 1178 FEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMK------VSFYEHEHNISRFD 1231 FEE+I KL+I RD RNPLFD + LQNI F+ E+ VS EH ++FD Sbjct: 3454 FEELIEKLEIQRDLSRNPLFDTLFSLQNIGEESFELAELTCKPFDLVSKLEH----AKFD 3509 Query: 1232 ITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSEN 1291 ++L +E + + +YCT+L+K +TVE + + IV ++ + ++++SDI M+SE Sbjct: 3510 LSLVAVEKEEEIAF-GLQYCTKLYKEKTVEQLAQHFIQIVKAIVENPDVKLSDIDMLSEE 3568 Query: 1292 AVQQI-LAFNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLAR 1350 +QI L FN T P +QTI LFEEQ K+ + A+ + Q ++Y ELN +ANQLAR Sbjct: 3569 EKKQIMLEFNDTKIQYPQNQTIQELFEEQVKKTPEHIAIVWEGQALTYHELNIKANQLAR 3628 Query: 1351 LLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQL 1410 +LREKGVT V +M ERS EM++G ILK+GGAY+PIDP YP ERI++++EDSG L Sbjct: 3629 VLREKGVTPNHPVAIMTERSLEMIVGIFSILKAGGAYVPIDPAYPQERIQYLLEDSGATL 3688 Query: 1411 VLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLL 1470 +LTQ+ N L D E +DL DG+NLP +N+S+DLAY+IYTSGTTGKPKG ++ Sbjct: 3689 LLTQSHVLNKLPVDIEWLDLTDEQNYVEDGTNLPFMNQSTDLAYIIYTSGTTGKPKGVMI 3748 Query: 1471 EHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDN 1530 EH+ I+N KE+ + + +Q S +FD + + IL G T L +E D Sbjct: 3749 EHQSIINCLQWRKEEYEFGPGDTALQVFSFAFDGFVASLFAPILAGATSVLPKEEEAKDP 3808 Query: 1531 SCFEAFLNSNRITAAI-LPPTYLANLNPNNIHTVDKM--ITIGS----AISSGLVNEWKR 1583 + + S IT +P + A L+ ++ + + +T+G A + E + Sbjct: 3809 VALKKLIASEEITHYYGVPSLFSAILDVSSSKDLQNLRCVTLGGEKLPAQIVKKIKEKNK 3868 Query: 1584 KCEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGE 1643 + E N YGPTE +V +++ + +V+ + IG P+ N +YI++ LQPVG+ GE Sbjct: 3869 EIEVNNEYGPTENSVVTTIM---RDIQVEQEITIGCPLSNVDVYIVNCNHQLQPVGVVGE 3925 Query: 1644 LCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVK 1703 LCIGG GL RGY +PE+TADK + ++Y+TGDLA+W DG +EY+GR+DEQVK Sbjct: 3926 LCIGGQGLARGYLNKPELTADKFVVNPFVPGERMYKTGDLAKWRSDGMIEYVGRVDEQVK 3985 Query: 1704 IRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSK 1763 +RG+R+E EI++ +L+ E IK+ +V ++ +CAY + D +LR L Sbjct: 3986 VRGYRIELGEIESAILEYEKIKEAVVIVSEHTASEQMLCAYIVGEEDVLTLDLRSYLAKL 4045 Query: 1764 LPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEV 1823 LP +MIP YF+++++ PLT NGK+D+K LP P+ Y+ PRNEIE L +W+EV Sbjct: 4046 LPSYMIPNYFIQLDSIPLTPNGKVDRKALPEPQTIGLMAREYVAPRNEIEAQLVLIWQEV 4105 Query: 1824 LRLEKVGIEDNFFEVGGDSLKA-MQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRN 1882 L +E +GI DNFFE+GG SLKA + VA I ++ M + +F I +++E + + Sbjct: 4106 LGIELIGITDNFFELGGHSLKATLLVAKIYEYMQIEMPLNVVFKHSTIMKIAEYITHQES 4165 Query: 1883 NPIVENPV 1890 V P+ Sbjct: 4166 ENNVHQPI 4173 Score = 1322 bits (3422), Expect = 0.0, Method: Compositional matrix adjust. Identities = 747/2139 (34%), Positives = 1221/2139 (57%), Gaps = 101/2139 (4%) Query: 12 LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKE--SLRLDIPDGLFQQLQHL 69 L + ++ +YW ++ D + K+A+ E R L QQL + Sbjct: 190 LEKQDKQEALRYWKEHLMNY--DQSVTLPKKKAAINNTTYEPAQFRFAFDKVLTQQLLRI 247 Query: 70 SNRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEA------YNHYVPIID 123 +N+S +L + T ++ K+ ++ + S V + S + + +P+ Sbjct: 248 ANQSQVTLNIVFQTIWGIVLQKYNSTNDVVYGSVVSGRPSEISGIEKMVGLFINTLPLRI 307 Query: 124 TFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLC-----LL 178 +F E + V + L + H+ +P + ++Q ++ + + H++ L+ Sbjct: 308 QTQKDQSFIELVKTVHQNVLFSQQHEYFP----LYEIQNHTELKQNLIDHIMVIENYPLV 363 Query: 179 TNIHNDAVIPDVGSNI--------------VFGFTRDDAGISLNLIYNLKYFTRNFVMQL 224 + ++++ VG + V RD+ IS+ L YN + +F+ ++ Sbjct: 364 EELQKNSIMQKVGFTVRDVKMFEPTNYDMTVMVLPRDE--ISVRLDYNAAVYDIDFIRKI 421 Query: 225 AKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQT 284 ++ A N + + + + D T+++LF +QV +T Sbjct: 422 EGHMKEVALCVANNPHVLVQDVPLLTKQEKQHLLVELHDSITEYPDKTIHQLFTEQVEKT 481 Query: 285 PDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKS 344 P+HVAV F ++ +TYR+L+ ++N+LAR LR +GV I+G+++ERS++M GILGILK+ Sbjct: 482 PEHVAVVFEDEKVTYRELHERSNQLARFLREKGVKKESIIGIMMERSVEMIVGILGILKA 541 Query: 345 GAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDL 404 G A++P+D + P+ER+ ++++ + + ++ + ++K T++ D + E ++ Sbjct: 542 GGAFVPIDPEYPKERIGYMLD--SVRLVLTQRHLKDKFAFTKETIVIEDPSISHELTEEI 599 Query: 405 DLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYI 464 D I + Y+IYTSGTTG+PKGV++EH++I N + + + + + SD++LQ + Sbjct: 600 DYI--NESEDLFYIIYTSGTTGKPKGVMLEHKNIVNLLHFTFEKTNINFSDKVLQYTTCS 657 Query: 465 FDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKP 524 FD F+ ++SG + + + RD + L+ I ++ P + + N + Sbjct: 658 FDVCYQEIFSTLLSGGQLYLIRKETQRDVEQLFDLVKRENI-EVLSFPVAFLKFIFNERE 716 Query: 525 ---EEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDT 581 ++ + AGE++ N + + N YGP+E+ V+ T + + + Sbjct: 717 FINRFPTCVKHIITAGEQLVVNNEFKRYLHEHNVHLHNHYGPSETHVVTTYTINPEAEIP 776 Query: 582 ELT-IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFE 640 EL IGKPI NT +YI+ +L+ G+VGEL ISGA + RGYL+N+ LT +KF ++PF Sbjct: 777 ELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGANVGRGYLNNQELTAEKFFADPFR 836 Query: 641 ANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALW 700 NERMYRTGDLARW G IE +GRAD QVK+RG+RIELGEIE +LL G+ EAVV Sbjct: 837 PNERMYRTGDLARWLPDGNIEFLGRADHQVKIRGHRIELGEIEAQLLNCKGVKEAVVIDK 896 Query: 701 EDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNAL 760 D +CAY+V + ++ ELRE L K+LP+YM+P+ F L+Q P+TP GK+DR +L Sbjct: 897 ADDKGGKYLCAYVVMEVEVNDSELREYLGKALPDYMIPSFFVPLDQLPLTPNGKIDRKSL 956 Query: 761 RNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRL 820 N + + A++ PTNE+E +L +IW+ VL + ++ I DNFF LGGHSLKA L+SR+ Sbjct: 957 PNLEGIVNTNAKYVVPTNELEEKLAKIWEEVLGISQIGIQDNFFSLGGHSLKAITLISRM 1016 Query: 821 HKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYH 880 +KE V+I L +FE TI ++ I + +Y +I P +++YYP+SS QKRM+ L Sbjct: 1017 NKECNVDIPLRLLFEAPTIQEISNYINGAKKESYVAIQPVPEQEYYPVSSVQKRMFILNE 1076 Query: 881 LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDF 940 + T+YN+P VM ++G+L+ Q+E+ +++++ RHE LRTSFH I+ EPVQ VH ++ Sbjct: 1077 FDRSGTAYNLPGVMFLDGKLNYRQLEAAVKKLVERHEALRTSFHSINGEPVQRVHQNVEL 1136 Query: 941 SIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIG 1000 I Y+E D + F+QPF L+ +PL RV ++K+ + +LF+ DMHHIISDG+S+ Sbjct: 1137 QIAYSESTEDQVERIIAEFMQPFALEVAPLLRVGLVKLEAERHLFIMDMHHIISDGVSMQ 1196 Query: 1001 LFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPV 1060 + I+E+A LY LP IQ+KDF+VW ++ ++QE +WL +F E+P+L LP Sbjct: 1197 IMIQEIADLYKEKELPTLGIQYKDFTVWHNRLLQSDVIEKQEAYWLNVFTEEIPVLNLPT 1256 Query: 1061 DYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDII 1120 DY RP +S++G + F+ K+ L ++A + G TLYM+LLA +N+ LSK + Q+DI+ Sbjct: 1257 DYPRPTIQSFDGKRFTFSTGKQLMDDLYKVATETGTTLYMVLLAAYNVFLSKYSGQDDIV 1316 Query: 1121 VGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEE 1180 VG+P+ R ++E+++GMF NTLA+R+ FKDFL VK +AL A++N DY F+ Sbjct: 1317 VGTPIAGRSHADVENMLGMFVNTLAIRSRLNNEDTFKDFLANVKQTALHAYENPDYPFDT 1376 Query: 1181 MISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGL 1240 ++ KL I RD RNPLFD M +LQN F+ ++ ++ Y S+FD+TL E Sbjct: 1377 LVEKLGIQRDLSRNPLFDTMFVLQNTDRKSFEVEQITITPYVPNSRHSKFDLTLEVSEEQ 1436 Query: 1241 DGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AF 1299 + +L C EYCT+LF +TVE M + I++ ++ + I IS+I ++SE Q IL F Sbjct: 1437 NEILLC-LEYCTKLFTDKTVERMAGHFLQILHAIVGNPTIIISEIEILSEEEKQHILFEF 1495 Query: 1300 NQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTA 1359 N T P QTI GLFEEQ ++ D A+ + DQ ++Y ELN+RANQ+AR+LR+KGV Sbjct: 1496 NDTKTTYPHMQTIQGLFEEQVEKTPDHVAVGWKDQALTYRELNERANQVARVLRQKGVQP 1555 Query: 1360 GSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYN 1419 ++VGL+ ERS EM++G +GILK+GGAYLP+DP+YP +RI +MI+D G++++LTQ + Sbjct: 1556 DNIVGLLVERSPEMLVGIMGILKAGGAYLPLDPEYPADRISYMIQDCGVRIMLTQQHLLS 1615 Query: 1420 WLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLT 1479 + + + + L+ L D SNL +N++ DLAY++YTSG+TGKPKG ++EH+ ++ L Sbjct: 1616 LVHDEFDCVILDEDSLYKGDSSNLAPVNQAGDLAYIMYTSGSTGKPKGVMVEHRNVIRL- 1674 Query: 1480 ASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNS 1539 N +++++ +R++Q +I FD ++ S+L G L TK++L D FL + Sbjct: 1675 VKNTNYVQVREDDRIIQTGAIGFDALTFEVFGSLLHGAELYPVTKDVLLDAEKLHKFLQA 1734 Query: 1540 NRITAAILPPTYLANLNPNN---IHTVDKMITIGSAISSGLVNEWKRKCEYI---NAYGP 1593 N+IT L L+ + +I G A+S +N KRKC + N YGP Sbjct: 1735 NQITIMWLTSPLFNQLSQGTEEMFAGLRSLIVGGDALSPKHINNVKRKCPNLTMWNGYGP 1794 Query: 1594 TETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTR 1653 TE T +S+ ++ +K E DD +PIGK I N+ +YI+D+Y LQPVG+PGELC+GG G+ R Sbjct: 1795 TENTTFSTCFLIDK--EYDDNIPIGKAISNSTVYIMDRYGQLQPVGVPGELCVGGDGVAR 1852 Query: 1654 GYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQE 1713 GY +P +T +K + + ++YRTGDLARWLPDG +EYLGR+D+QVKIRG+R+EP E Sbjct: 1853 GYMNQPALTEEKFVPNPFAPGERMYRTGDLARWLPDGTIEYLGRIDQQVKIRGYRIEPGE 1912 Query: 1714 IKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYF 1773 I+ L+K + +K+ ++ ++ ++CAYY+ + +V+ELR+ + +LP +M+PAYF Sbjct: 1913 IETLLVKHKKVKESVIMVVEDNNGQKALCAYYVPEEEVTVSELREYIAKELPVYMVPAYF 1972 Query: 1774 VRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIED 1833 V++E PLT NGK+++ LP P+ + Y+ P ++IE+ LAE+W VL + K+G+ D Sbjct: 1973 VQIEQMPLTQNGKVNRSALPKPDGEFGTATEYVAPSSDIEMKLAEIWHNVLGVNKIGVLD 2032 Query: 1834 NFFEVGGDSLKAM-QVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGR 1892 NFFE+GG SL+AM ++ + + + + +K LF I+ L++ + D Sbjct: 2033 NFFELGGHSLRAMTMISQVHKEFDVELPLKVLFETPTISALAQYIAD------------- 2079 Query: 1893 IDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVH 1952 G +G + + + Q+ S + + A Y++ N + Sbjct: 2080 ----GEKG-------MYLAIQPVTPQDYYPVSSAQKRMYILYEFEGAGITYNVPNVMFIE 2128 Query: 1953 TSIPFRSCGDIGKIQKAILRLVNEQVLLRSVIVNDGENTYFYEHGSVYNLPFILIDLS-G 2011 + D + + AI L+N LR+ +++ +G ++L Sbjct: 2129 GKL------DYQRFEYAIKSLINRHEALRT--------SFYSLNGEPVQRVHQNVELQIA 2174 Query: 2012 FDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGI 2071 + A+ E ++ PF+ + R+ LV+ A + ++ L H +SDG+S+ I Sbjct: 2175 YSEAKEDEIEQIVESFVQ--PFDLEIAPALRVGLVKLASDRHLFLMDMHHIISDGVSMQI 2232 Query: 2072 ITDQLAAYFAGDSSLPVH----SLKHHQNYWDYADQMQK 2106 IT ++A + G +H QN W + ++K Sbjct: 2233 ITKEIADLYKGKELAELHIQYKDFAVWQNEWFQSAALEK 2271 Score = 532 bits (1370), Expect = e-149, Method: Compositional matrix adjust. Identities = 386/1278 (30%), Positives = 646/1278 (50%), Gaps = 116/1278 (9%) Query: 863 RDYYPMSSAQKRMYALYH--LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILR 920 +D Y +S Q+ M L+H L+ + ++ + + +EG +DV + L +I R+++ R Sbjct: 10 QDMYRLSPMQEGM--LFHALLDKDKNAHLVQMSIAIEGIVDVELLSESLNILIDRYDVFR 67 Query: 921 TSF-HMIHHEPVQVV----------HDTIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSP 969 T+F H +P+QVV D + E+ I+ + + + FDL P Sbjct: 68 TTFLHEKIKQPLQVVLKERPVQLQFKDISSLDEEKREQAIEQYKYQDGETV--FDLTRDP 125 Query: 970 LFRVKIIKIASRHYLFMFDMHHIISDG----------ISIGLFIKELALLYGNAVLPEPE 1019 L RV I + +Y ++ HHI+ DG +I L +KE L AV P Sbjct: 126 LMRVAIFQTGKVNYQMIWSFHHILMDGWCFNIIFNDLFNIYLSLKEKKPLQLEAVQP--- 182 Query: 1020 IQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTL 1079 +K F W E D ++ +W + + LP + +YE ++ F Sbjct: 183 --YKQFIKW----LEKQDKQEALRYWKEHLMNYDQSVTLPKKKAAINNTTYEPAQFRFAF 236 Query: 1080 DKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQ--VELESVM 1137 DK T++L +A + TL ++ ++ I+L K + D++ GS V+ R +E ++ Sbjct: 237 DKVLTQQLLRIANQSQVTLNIVFQTIWGIVLQKYNSTNDVVYGSVVSGRPSEISGIEKMV 296 Query: 1138 GMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLF 1197 G+F NTL +R ++ F + + V + L + ++ + E+ + ++ ++ L Sbjct: 297 GLFINTLPLRIQTQKDQSFIELVKTVHQNVLFSQQHEYFPLYEIQNHTELKQN-----LI 351 Query: 1198 DAMLILQNIA-VNQFQFGEM--KVSFYEHEHNI---SRFDITLHCLEGLDGLLHCSFEYC 1251 D +++++N V + Q + KV F + + + +D+T+ L + + +Y Sbjct: 352 DHIMVIENYPLVEELQKNSIMQKVGFTVRDVKMFEPTNYDMTVMVLPRDE--ISVRLDYN 409 Query: 1252 TRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILAFNQTSFDLPADQT 1311 ++ + + + ++K + V + + + D+ ++++ Q +L S D+T Sbjct: 410 AAVYDIDFIRKIEGHMKEVALCVANNPHVLVQDVPLLTKQEKQHLLVELHDSITEYPDKT 469 Query: 1312 IHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSF 1371 IH LF EQ ++ + A+ F D+ ++Y EL++R+NQLAR LREKGV S++G+M ERS Sbjct: 470 IHQLFTEQVEKTPEHVAVVFEDEKVTYRELHERSNQLARFLREKGVKKESIIGIMMERSV 529 Query: 1372 EMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLN 1431 EM++G LGILK+GGA++PIDP+YP ERI +M++ ++LVLTQ + F E I + Sbjct: 530 EMIVGILGILKAGGAFVPIDPEYPKERIGYMLD--SVRLVLTQRHLKDKFAFTKETIVIE 587 Query: 1432 CAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDR 1491 +++ + IN S DL Y+IYTSGTTGKPKG +LEHK IVNL E+ I Sbjct: 588 DPSISHELTEEIDYINESEDLFYIIYTSGTTGKPKGVMLEHKNIVNLLHFTFEKTNINFS 647 Query: 1492 ERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTY 1551 ++V+Q+++ SFDV +I ++L GG L L KE D + I P + Sbjct: 648 DKVLQYTTCSFDVCYQEIFSTLLSGGQLYLIRKETQRDVEQLFDLVKRENIEVLSFPVAF 707 Query: 1552 LA---------NLNPNNIHTVDKMITIGSAISSGLVNEWKR-----KCEYINAYGPTETT 1597 L N P V +IT G + NE+KR N YGP+ET Sbjct: 708 LKFIFNEREFINRFPT---CVKHIITAGEQLVVN--NEFKRYLHEHNVHLHNHYGPSETH 762 Query: 1598 VYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWK 1657 V ++ I N + E+ + PIGKPI NT +YILD+ + LQP GI GEL I G + RGY Sbjct: 763 VVTTYTI-NPEAEIPELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGANVGRGYLN 821 Query: 1658 RPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAE 1717 E+TA+K ++YRTGDLARWLPDGN+E+LGR D QVKIRG R+E EI+A+ Sbjct: 822 NQELTAEKFFADPFRPNERMYRTGDLARWLPDGNIEFLGRADHQVKIRGHRIELGEIEAQ 881 Query: 1718 LLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRME 1777 LL +G+K+ +V + + +CAY + ++ + +ELR+ L LP++MIP++FV ++ Sbjct: 882 LLNCKGVKEAVVIDKADDKGGKYLCAYVVMEVEVNDSELREYLGKALPDYMIPSFFVPLD 941 Query: 1778 AFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFE 1837 PLT NGKID+K LP E + ++ Y+ P NE+E LA++WEEVL + ++GI+DNFF Sbjct: 942 QLPLTPNGKIDRKSLPNLEGIVNTNAKYVVPTNELEEKLAKIWEEVLGISQIGIQDNFFS 1001 Query: 1838 VGGDSLKAMQVAAILGKH-RLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSS 1896 +GG SLKA+ + + + K + + ++ LF I E+S I+ + Sbjct: 1002 LGGHSLKAITLISRMNKECNVDIPLRLLFEAPTIQEIS----------------NYINGA 1045 Query: 1897 GTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIP 1956 E +I+ + +QE S++ + + Y+L + + Sbjct: 1046 KKESYVAIQ--------PVPEQEYYPVSSVQKRMFILNEFDRSGTAYNLPGVMFLDGKLN 1097 Query: 1957 FRSCGDIGKIQKAILRLVNEQVLLRSVIVN-DGENTYFYEHGSVYNLPFILIDLSGFDAA 2015 +R +++ A+ +LV LR+ + +GE + + S D Sbjct: 1098 YR------QLEAAVKKLVERHEALRTSFHSINGEPVQRVHQNVELQIAY---SESTEDQV 1148 Query: 2016 RRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQ 2075 R ++Q PF + L R+ LV+ E ++ + H +SDG+S+ I+ + Sbjct: 1149 ERI-IAEFMQ------PFALEVAPLLRVGLVKLEAERHLFIMDMHHIISDGVSMQIMIQE 1201 Query: 2076 LAAYFAGDSSLPVHSLKH 2093 +A + + LP +++ Sbjct: 1202 IADLYK-EKELPTLGIQY 1218 >sp|P14688|GRSB_BACBR Gramicidin S synthetase II [Includes: ATP-dependent proline adenylase (PROA) (Proline activase); ATP-dependent valine adenylase (VALA) (Valine activase); ATP-dependent ornithine adenylase (ORNA) (Ornithine activase); ATP-dependent leucine adenylase (LEUA) (Leucine activase)] pir||YGBSG2 gramicidin S synthetase (EC 6.-.-.-) component II - Bacillus brevis emb|CAA43838.1| grsB [Brevibacillus brevis] Length = 4452 Score = 1326 bits (3431), Expect = 0.0, Method: Compositional matrix adjust. Identities = 744/1928 (38%), Positives = 1131/1928 (58%), Gaps = 60/1928 (3%) Query: 9 NVLLSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQ 67 N + ++K+K YWLN + TD P + EG + + L ++L+ Sbjct: 2262 NEWFQSDALEKQKTYWLNTFAEDIPVLNLSTDYPRPTIQSFEG-DIVTFSAGKQLAEELK 2320 Query: 68 HLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIID 123 L+ + +LY +LL A L+ K++ I V +P+ + D + + + + + + Sbjct: 2321 RLAAETGTTLYMLLLAAYNVLLHKYSGQEEIVVGTPIAGRSHADVENIVGMFVNTLALKN 2380 Query: 124 TFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN 183 T TF E LL+V++ L A+++QDYPF+ +IE +Q D + + + L+NI Sbjct: 2381 TPIAVRTFHEFLLEVKQNALEAFENQDYPFENLIEKLQVRRDLSRNPLFDTMFSLSNIDE 2440 Query: 184 DAVIPDVGSN--------------IVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYF 229 I G N I F I Y F + + +LA + Sbjct: 2441 QVEIGIEGLNFSPYEMQYWIAKFDISFDILEKQDDIQFYFNYCTNLFKKETIERLATHFM 2500 Query: 230 QILKGAAENVSIKLGSMXXXXXXXXXXXXXX---QTRTYQNMEDMTLYELFEKQVRQTPD 286 IL+ N IKL + TY + +ELFE+QV +TPD Sbjct: 2501 HILQEIVINPEIKLCEINMLSEEEQQRVLYDFNGTDATYAT--NKIFHELFEEQVEKTPD 2558 Query: 287 HVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGA 346 H+AV + ++Y++LNAKAN+LARVLR +GV N +VG++V+RS+DM G+LG+LK+G Sbjct: 2559 HIAVIDEREKLSYQELNAKANQLARVLRQKGVQPNSMVGIMVDRSLDMIVGMLGVLKAGG 2618 Query: 347 AYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDL 406 AY+P+DI P+ER+ +++ED+G + ++ ++ +++ G ++ LD + L E+ Sbjct: 2619 AYVPIDIDYPQERISYMMEDSGAALLLTQQKLTQQIAFSG-DILYLDQEEWLHEEASNLE 2677 Query: 407 ILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASD-RMLQL--FSY 463 + R + AY+IYTSGTTG+PKGV+IEH+S N K Y D R+LQ+ F++ Sbjct: 2678 PIARP-HYIAYIIYTSGTTGKPKGVMIEHQSYVNVAMAWKDAYRLDTFPVRLLQMASFAF 2736 Query: 464 IFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMK 523 FD F +++G ++ DP ++ +I + IT F A P L L+ + Sbjct: 2737 AFDVSAGDFARALLTGGQLIVCPNEVKMDPASLYAIIKKYDITIFEATPALVIPLMEYIY 2796 Query: 524 PE--EAQSLRIVTLAGEKVT-PNLLIASKQLHPGMEIVNEYGPTESS-VLATLKRDLKPD 579 + + L+I+ + + + + + + IVN YG TE++ +LA + + L Sbjct: 2797 EQKLDISQLQILIVGSDSCSMEDFKTLVSRFGSTIRIVNSYGVTEAALILAIMNQPLSSL 2856 Query: 580 DTELT--IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSN 637 T IGKP N ++YI+ L+++ G++GELCI GAG+ARGYL+ LT +KFV N Sbjct: 2857 HVTGTVPIGKPYANMKMYIMNQYLQIQPVGVIGELCIGGAGVARGYLNRPDLTAEKFVPN 2916 Query: 638 PFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVV 697 PF E++YRTGDLARW G +E +GR D QVK+RG RIELGEIE +L +++ I EA V Sbjct: 2917 PFVPGEKLYRTGDLARWMPDGNVEFLGRNDHQVKIRGIRIELGEIEAQLRKHDSIKEATV 2976 Query: 698 ALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDR 757 ED +CAY+V + ++ ELR L+ M+P++F LE P+T GK+D+ Sbjct: 2977 IAREDHMKEKYLCAYMVTEGEVNVAELRAYLANDRAA-MIPSYFVSLEAMPLTANGKIDK 3035 Query: 758 NALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLL 817 +L +G + P +E +L EIWK+VL + +V IHD+FF +GGHSLKA ++ Sbjct: 3036 RSLPEPDGSISIGTEYDRPRTMLEGKLEEIWKDVLGLQRVGIHDDFFTIGGHSLKAMAVI 3095 Query: 818 SRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYA 877 S++HKE Q E+ L +FE TI LA I+ Y +I P +DYYP+SSAQKRM+ Sbjct: 3096 SQVHKECQTEVPLRVLFETPTIQGLAKYIEETDTEQYMAIQPVSGQDYYPVSSAQKRMFI 3155 Query: 878 LYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDT 937 + G SYNMP +M++EG+L+ ++ES +++I RHE LRTSF +I+ +PVQ +H+ Sbjct: 3156 VNQFVGVGISYNMPSIMLIEGKLERTRLESAFKRLIERHESLRTSFEIINGKPVQKIHEE 3215 Query: 938 IDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGI 997 +DF++ Y + + D FIQPFDL +PL RV+++K+ ++ +FDMHHIISDGI Sbjct: 3216 VDFNMSYQVASNEQVEKMIDEFIQPFDLSVAPLLRVELLKLEEDRHVLIFDMHHIISDGI 3275 Query: 998 SIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLE 1057 S + +KEL LY LPE IQ+KDF+VW+ E ++ FK+QEE+W+ +F E P+L+ Sbjct: 3276 SSNILMKELGELYQGNALPELRIQYKDFAVWQNEWFQSEAFKKQEEYWVNVFADERPILD 3335 Query: 1058 LPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQE 1117 +P DY RP+ +S++G+++ F K+ L +A + G TLYM+LLA +N++LSK + QE Sbjct: 3336 IPTDYPRPMQQSFDGAQLTFGTGKQLMDGLYRVATETGTTLYMVLLAAYNVLLSKYSGQE 3395 Query: 1118 DIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQ 1177 DIIVG+P+ R +LE+++GMF NTLAMRN P G K FK F++E+K +AL+AF+NQDY Sbjct: 3396 DIIVGTPIVGRSHTDLENIVGMFVNTLAMRNKPEGEKTFKAFVSEIKQNALAAFENQDYP 3455 Query: 1178 FEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMK------VSFYEHEHNISRFD 1231 FEE+I KL+I RD RNPLFD + LQNI F+ E+ VS EH ++FD Sbjct: 3456 FEELIEKLEIQRDLSRNPLFDTLFSLQNIGEESFELAELTCKPFDLVSKLEH----AKFD 3511 Query: 1232 ITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSEN 1291 ++L + + + +YCT+L+K +TVE + + IV ++ + ++++SDI M+SE Sbjct: 3512 LSLVAV-VFEEEIAFGLQYCTKLYKEKTVEQLAQHFIQIVKAIVENPDVKLSDIDMLSEE 3570 Query: 1292 AVQQI-LAFNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLAR 1350 +QI L FN T +QTI LFEEQ K+ + A+ + Q + Y ELN +ANQLAR Sbjct: 3571 EKKQIMLEFNDTKIQYTQNQTIQELFEEQVKKTPEHIAIVWEGQALIYHELNIKANQLAR 3630 Query: 1351 LLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQL 1410 +LREKGVT V +M ERS EM++G ILK+GGAY+PIDP YP ERI++++EDSG L Sbjct: 3631 VLREKGVTPNHPVAIMTERSLEMIVGIFSILKAGGAYVPIDPAYPQERIQYLLEDSGAAL 3690 Query: 1411 VLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLL 1470 +LTQ+ N L D E +DL DG+NLP +N+S+DLAY+IYTSGTTGKPKG ++ Sbjct: 3691 LLTQSHVLNKLPVDIEWLDLTDEQNYVEDGTNLPFMNQSTDLAYIIYTSGTTGKPKGVMI 3750 Query: 1471 EHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDN 1530 EH+ I+N KE+ + + +Q S +FD + + IL G T L +E D Sbjct: 3751 EHQSIINCLQWRKEEYEFGPGDTALQVFSFAFDGFVASLFAPILAGATSVLPKEEEAKDP 3810 Query: 1531 SCFEAFLNSNRITAAI-LPPTYLANLNPNNIHTVDKM--ITIGS----AISSGLVNEWKR 1583 + + S IT +P + A L+ ++ + + +T+G A + E + Sbjct: 3811 VALKKLIASEEITHYYGVPSLFSAILDVSSSKDLQNLRCVTLGGEKLPAQIVKKIKEKNK 3870 Query: 1584 KCEYINAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGE 1643 + E N YGPTE +V +++ + +V+ + IG+P+ N +YI++ LQPVG+ GE Sbjct: 3871 EIEVNNEYGPTENSVVTTIM---RDIQVEQEITIGRPLSNVDVYIVNCNHQLQPVGVVGE 3927 Query: 1644 LCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVK 1703 LCIGG GL RGY +PE+TADK + ++Y+TGDLA+W DG +EY+GR+DEQVK Sbjct: 3928 LCIGGQGLARGYLNKPELTADKFVVNPFVPGERMYKTGDLAKWRSDGMIEYVGRVDEQVK 3987 Query: 1704 IRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSK 1763 +RG+R+E EI++ +L+ E IK+ +V ++ +CAY + D +LR L Sbjct: 3988 VRGYRIELGEIESAILEYEKIKEAVVMVSEHTASEQMLCAYIVGEEDVLTLDLRSYLAKL 4047 Query: 1764 LPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEV 1823 LP +MIP YF+++++ PLT NGK+D+K LP P+ Y+ PRNEIE L +W+EV Sbjct: 4048 LPSYMIPNYFIQLDSIPLTPNGKVDRKALPEPQTIGLMAREYVAPRNEIEAQLVLIWQEV 4107 Query: 1824 LRLEKVGIEDNFFEVGGDSLKA-MQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRN 1882 L +E +GI DNFFE+GG SLKA + VA I ++ M + +F I +++E + + Sbjct: 4108 LGIELIGITDNFFELGGHSLKATLLVAKIYEYMQIEMPLNVVFKHSTIMKIAEYITHQES 4167 Query: 1883 NPIVENPV 1890 V P+ Sbjct: 4168 ENNVHQPI 4175 Score = 1303 bits (3371), Expect = 0.0, Method: Compositional matrix adjust. Identities = 763/2086 (36%), Positives = 1192/2086 (57%), Gaps = 122/2086 (5%) Query: 79 YILLTALKWLIVKHTESSIITVASPV----YMDENSTSEAYNHYVPIIDTFTTGMTFRES 134 + L + + + K++ I V +P+ + D + + + + I TF++ Sbjct: 1297 WFYLLRIMFFLSKYSGQDDIVVGTPIAGRSHADVENMLGMFVNTLAIRSRLNNEDTFKDF 1356 Query: 135 LLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTN-------IHNDAVI 187 L V++T L AY++ DYPFD ++E + D + + + +L N + + Sbjct: 1357 LANVKQTALHAYENPDYPFDTLVEKLGIQRDLSRNPLFDTMFVLQNTDRKSFEVEQITIT 1416 Query: 188 PDVGS------NIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQILKGAAENVSI 241 P V + ++ + + I L L Y K FT V ++A + QIL N +I Sbjct: 1417 PYVPNSRHSKFDLTLEVSEEQNEILLCLEYCTKLFTDKTVERMAGHFLQILHAIVGNPTI 1476 Query: 242 KLGSMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEK-------QVRQTPDHVAVKFNN 294 + + Q ++ + T Y L ++ + R+ DHVAV + + Sbjct: 1477 IISEIEILSEEEK------QHILFEFNDTKTTYPLCKQFKDYLRNRWRRRADHVAVGWKD 1530 Query: 295 QSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLPLDIK 354 Q++TYR+LN +AN++ARVLR +GV + IVGLLVERS +M GI+GILK+G AYLPLD + Sbjct: 1531 QTLTYRELNERANQVARVLRQKGVQPDNIVGLLVERSPEMLVGIMGILKAGGAYLPLDPE 1590 Query: 355 SPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDLILGRALDH 414 P +R+ ++I+D G+ + ++ +Q L D + LD+D L + +S + +A D Sbjct: 1591 YPADRISYMIQDCGVRIMLT-QQHLLSLVHDEFDCVILDEDSLYKGDSSNLAPVNQAGDL 1649 Query: 415 PAYVIYTSGTTGQPKGVIIEHRSI------SNTIQWRKSEYSFDASDRMLQLFSYIFDGF 468 AY++YTSG+TG+PKGV++EHR++ +N +Q R+ DR++Q + FD Sbjct: 1650 -AYIMYTSGSTGKPKGVMVEHRNVIRLVKNTNYVQVRED-------DRIIQTGAIGFDAL 1701 Query: 469 LTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQ 528 F ++ GA + + + D + + + ++IT L++ L + + E Sbjct: 1702 TFEVFGSLLHGAELYPVTKDVLLDAEKLHKFLQANQITIMWLTSPLFNQLSQGTE-EMFA 1760 Query: 529 SLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELTIGKP 588 LR + + G+ ++P + K+ P + + N YGPTE++ +T K D + IGK Sbjct: 1761 GLRSLIVGGDALSPKHINNVKRKCPNLTMWNGYGPTENTTFSTCFLIDKEYDDNIPIGKA 1820 Query: 589 IGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYRT 648 I N+ VYI+ +L+ G+ GELC+ G G+ARGY++ LT +KFV NPF ERMYRT Sbjct: 1821 ISNSTVYIMDRYGQLQPVGVPGELCVGGDGVARGYMNQPALTEEKFVPNPFAPGERMYRT 1880 Query: 649 GDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNSR 708 GDLARW G IE +GR D QVK+RGYRIE GEIE L+++ + E+V+ + ED N Sbjct: 1881 GDLARWLPDGTIEYLGRIDQQVKIRGYRIEPGEIETLLVKHKKVKESVIMVVEDNNGQKA 1940 Query: 709 ICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLKE 768 +CAY V + ++ ELRE ++K LP YM+P +F Q+EQ P+T GK++R+AL Sbjct: 1941 LCAYYVPEEEVTVSELREYIAKELPVYMVPAYFVQIEQMPLTQNGKVNRSALPKPDGEFG 2000 Query: 769 LGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVEI 828 + P+++IE +L EIW NVL V+K+ + DNFF LGGHSL+A ++S++HKEF VE+ Sbjct: 2001 TATEYVAPSSDIEMKLAEIWHNVLGVNKIGVLDNFFELGGHSLRAMTMISQVHKEFDVEL 2060 Query: 829 ELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTSY 888 L +FE TI LA I + G Y +I P DYYP+SSAQKRMY LY EG +Y Sbjct: 2061 PLKVLFETPTISALAQYIADGQKGMYLAIQPVTPTDYYPVSSAQKRMYILYEFEGAGITY 2120 Query: 889 NMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYTEEK 948 N+P VM +EG+LD + E ++ +++RHE LRTSF+ ++ EPVQ VH ++ I Y+E K Sbjct: 2121 NVPNVMFIEGKLDYQRFEYAIKSLVNRHEALRTSFYSLNGEPVQRVHQNVELQIAYSEAK 2180 Query: 949 IDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELAL 1008 D+I + F+QPFDL+ +PL RV ++K+AS YLF+ DMHHIISDG+S+ + KE+A Sbjct: 2181 EDEIEQIVESFVQPFDLEIAPLLRVGLVKLASDRYLFLMDMHHIISDGVSMQIITKEIAD 2240 Query: 1009 LYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHK 1068 LY L E IQ+KDF+VW+ E ++ ++Q+ +WL F ++P+L L DY RP + Sbjct: 2241 LYKGKELAELHIQYKDFAVWQNEWFQSDALEKQKTYWLNTFAEDIPVLNLSTDYPRPTIQ 2300 Query: 1069 SYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRR 1128 S+EG + F+ K+ +LK LA + G TLYMLLLA +N++L K + QE+I+VG+P+ R Sbjct: 2301 SFEGDIVTFSAGKQLAEELKRLAAETGTTLYMLLLAAYNVLLHKYSGQEEIVVGTPIAGR 2360 Query: 1129 RQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIV 1188 ++E+++GMF NTLA++N P + F +FL EVK +AL AF+NQDY FE +I KL + Sbjct: 2361 SHADVENIVGMFVNTLALKNTPIAVRTFHEFLLEVKQNALEAFENQDYPFENLIEKLQVR 2420 Query: 1189 RDTGRNPLFDAMLILQNIAVNQFQFGEMKVSF--YEHEHNISRFDITLHCLEGLDGLLHC 1246 RD RNPLFD M L NI Q + G ++F YE ++ I++FDI+ LE D + Sbjct: 2421 RDLSRNPLFDTMFSLSNID-EQVEIGIEGLNFSPYEMQYWIAKFDISFDILEKQDD-IQF 2478 Query: 1247 SFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILA-FNQTSFD 1305 F YCT LFK+ET+E + + I+ +++ + EI++ +I M+SE Q++L FN T Sbjct: 2479 YFNYCTNLFKKETIERLATHFMHILQEIVINPEIKLCEINMLSEEEQQRVLYDFNGTDAT 2538 Query: 1306 LPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGL 1365 ++ H LFEEQ ++ D A+ + +SY ELN +ANQLAR+LR+KGV S+VG+ Sbjct: 2539 YATNKIFHELFEEQVEKTPDHIAVIDEREKLSYQELNAKANQLARVLRQKGVQPNSMVGI 2598 Query: 1366 MFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDG 1425 M +RS +M++G LG+LK+GGAY+PID DYP ERI +M+EDSG L+LTQ + F G Sbjct: 2599 MVDRSLDMIVGMLGVLKAGGAYVPIDIDYPQERISYMMEDSGAALLLTQQKLTQQIAFSG 2658 Query: 1426 EVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQ 1485 +++ L+ + + SNL I R +AY+IYTSGTTGKPKG ++EH+ VN+ + K+ Sbjct: 2659 DILYLDQEEWLHEEASNLEPIARPHYIAYIIYTSGTTGKPKGVMIEHQSYVNVAMAWKDA 2718 Query: 1486 LKIQDRE-RVVQFSS--ISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRI 1542 ++ R++Q +S +FDVS D + ++L GG L + E+ D + A + I Sbjct: 2719 YRLDTFPVRLLQMASFAFAFDVSAGDFARALLTGGQLIVCPNEVKMDPASLYAIIKKYDI 2778 Query: 1543 T------AAILP---PTYLANLNPNNIHTVDKMITIGSAISS-----GLVNEWKRKCEYI 1588 T A ++P Y L+ + + +++ +GS S LV+ + + Sbjct: 2779 TIFEATPALVIPLMEYIYEQKLDISQL----QILIVGSDSCSMEDFKTLVSRFGSTIRIV 2834 Query: 1589 NAYGPTETTVYSSVWIANKQG-EVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIG 1647 N+YG TE + ++ V VPIGKP N +MYI+++Y +QPVG+ GELCIG Sbjct: 2835 NSYGVTEAALILAIMNQPLSSLHVTGTVPIGKPYANMKMYIMNQYLQIQPVGVIGELCIG 2894 Query: 1648 GIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGF 1707 G G+ RGY RP++TA+K + K+YRTGDLARW+PDGN+E+LGR D QVKIRG Sbjct: 2895 GAGVARGYLNRPDLTAEKFVPNPFVPGEKLYRTGDLARWMPDGNVEFLGRNDHQVKIRGI 2954 Query: 1708 RVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEF 1767 R+E EI+A+L K + IK+ V R++ ++ +CAY ++ + +V ELR L + Sbjct: 2955 RIELGEIEAQLRKHDSIKEATVIAREDHMKEKYLCAYMVTEGEVNVAELRAYLANDRAA- 3013 Query: 1768 MIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLE 1827 MIP+YFV +EA PLT+NGKID++ LP P+ S+ + Y PR +E L E+W++VL L+ Sbjct: 3014 MIPSYFVSLEAMPLTANGKIDKRSLPEPDGSISIGTEYDRPRTMLEGKLEEIWKDVLGLQ 3073 Query: 1828 KVGIEDNFFEVGGDSLKAMQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVE 1887 +VGI D+FF +GG SLKAM V + + H++ E+ +R L P ++ Sbjct: 3074 RVGIHDDFFTIGGHSLKAMAVISQV-------------HKECQTEVP--LRVLFETPTIQ 3118 Query: 1888 NPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMN 1947 I+ + TE +I+ + Q+ S + + Y++ + Sbjct: 3119 GLAKYIEETDTEQYMAIQ--------PVSGQDYYPVSSAQKRMFIVNQFVGVGISYNMPS 3170 Query: 1948 AEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRSV--IVNDGENTYFYEHGSVYNLPFI 2005 + + + +++ A RL+ LR+ I+N +E Sbjct: 3171 IMLIEGKL------ERTRLESAFKRLIERHESLRTSFEIINGKPVQKIHEE--------- 3215 Query: 2006 LIDLSGFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSD 2065 +D + +E + + D F + PF+ L R+ L++ + ++L++ H +SD Sbjct: 3216 -VDFNMSYQVASNEQVEKMIDEFIQ-PFDLSVAPLLRVELLKLEEDRHVLIFDMHHIISD 3273 Query: 2066 GLSLGIITDQLAAYFAGDSSLPVHSLKHH-----QNYWDYADQMQK 2106 G+S I+ +L + G+ +LP +++ QN W ++ +K Sbjct: 3274 GISSNILMKELGELYQGN-ALPELRIQYKDFAVWQNEWFQSEAFKK 3318 Score = 1220 bits (3156), Expect = 0.0, Method: Compositional matrix adjust. Identities = 724/2155 (33%), Positives = 1189/2155 (55%), Gaps = 132/2155 (6%) Query: 12 LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKE--SLRLDIPDGLFQQLQHL 69 L + ++ +YW ++ D + K+A+ E R L QQL + Sbjct: 190 LEKQDKQEALRYWKEHLMNY--DQSVTLPKKKAAINNTTYEPAQFRFAFDKVLTQQLLRI 247 Query: 70 SNRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEA------YNHYVPIID 123 +N+S +L + T ++ K+ ++ + S V + S + + +P+ Sbjct: 248 ANQSQVTLNIVFQTIWGIVLQKYNSTNHVVYGSVVSGRPSEISGIEKMVGLFINTLPLRI 307 Query: 124 TFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLC-----LL 178 +F E + V + L + H+ +P + ++Q ++ + + H++ L+ Sbjct: 308 QTQKDQSFIELVKTVHQNVLFSQQHEYFP----LYEIQNHTELKQNLIDHIMVIENYPLV 363 Query: 179 TNIHNDAVIPDVGSNI--------------VFGFTRDDAGISLNLIYNLKYFTRNFVMQL 224 + ++++ VG + V RD+ IS+ L YN + +F+ ++ Sbjct: 364 EELQKNSIMQKVGFTVRDVKMFEPTNYDMTVMVLPRDE--ISVRLDYNAAVYDIDFIKKI 421 Query: 225 AKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQT 284 ++ A N + + + + D T+++LF +QV +T Sbjct: 422 EGHMKEVALCVANNPHVLVQDVPLLTKQEKQHLLVELHDSITEYPDKTIHQLFTEQVEKT 481 Query: 285 PDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKS 344 P+HVAV F ++ +TYR+L+ ++N+LAR LR +GV I+G+++ERS++M GILGILK+ Sbjct: 482 PEHVAVVFEDEKVTYRELHERSNQLARFLREKGVKKESIIGIMMERSVEMIVGILGILKA 541 Query: 345 GAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDL 404 G A++P+D + P+ER+ ++++ + + ++ + ++K T++ D + E ++ Sbjct: 542 GGAFVPIDPEYPKERIGYMLD--SVRLVLTQRHLKDKFAFTKETIVIEDPSISHELTEEI 599 Query: 405 DLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYI 464 D I + Y+IYTSGTTG+PKGV++EH++I N + + + + + SD++LQ + + Sbjct: 600 DYI--NESEDLFYIIYTSGTTGKPKGVMLEHKNIVNLLHFTFEKTNINFSDKVLQYTNAV 657 Query: 465 FDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKP 524 FF+ ++SG + + + RD + L+ I ++ P + + N + Sbjct: 658 LTCVTKKFFSTLLSGGQLYLIRKETQRDVEQLFDLVKRENI-EVLSFPVAFLKFIFNERE 716 Query: 525 ---EEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDT 581 ++ + AGE++ N + + N YGP+E+ V+ T + + + Sbjct: 717 FINRFPTCVKHIITAGEQLVVNNEFKRYLHEHNVHLHNHYGPSETHVVTTYTINPEAEIP 776 Query: 582 ELT-IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFE 640 EL IGKPI NT +YI+ +L+ G+VGEL ISGA + RGYL+N+ LT +KF ++PF Sbjct: 777 ELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGANVGRGYLNNQELTAEKFFADPFR 836 Query: 641 ANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALW 700 NERMYRTGDLARW G IE +GRAD QVK+RG+RIELGEIE +LL G+ EAVV Sbjct: 837 PNERMYRTGDLARWLPDGNIEFLGRADHQVKIRGHRIELGEIEAQLLNCKGVKEAVVIDK 896 Query: 701 EDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNAL 760 D +CAY+V + ++ ELRE L K+LP+YM+P+ F L+ + GK+DR +L Sbjct: 897 ADDKGGKYLCAYVVMEVEVNDSELREYLGKALPDYMIPSFFVPLDHVRLHLNGKIDRKSL 956 Query: 761 RNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRL 820 N + + A++ PTNE+E +L +IW+ VL + ++ I DNFF LGGHSLKA L+SR+ Sbjct: 957 PNLEGIVNTNAKYVVPTNELEEKLAKIWEEVLGISQIGIQDNFFSLGGHSLKAITLISRM 1016 Query: 821 HKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYH 880 +KE V+I L +FE TI ++ I + +Y +I P +++YYP+SS QKRM+ L Sbjct: 1017 NKECNVDIPLRLLFEAPTIQEISNYINGAKKESYVAIQPVPEQEYYPVSSVQKRMFILNE 1076 Query: 881 LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDF 940 + T+YN+P VM ++G+L+ Q+E+ +++++ RHE LRTSFH I+ EPVQ VH ++ Sbjct: 1077 FDRSGTAYNLPGVMFLDGKLNYRQLEAAVKKLVERHEALRTSFHSINGEPVQRVHQNVEL 1136 Query: 941 SIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIG 1000 I Y+E D + F+QPF L+ PL RV ++K+ + +LF+ DMHHIISDG+S+ Sbjct: 1137 QIAYSESTEDQVERIIAEFMQPFALEVRPLLRVGLVKLEAERHLFIMDMHHIISDGVSMQ 1196 Query: 1001 LFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPV 1060 + I+E+A LY LP IQ+KDF+VW ++ ++Q E L E Sbjct: 1197 IMIQEIADLYKEKELPTLGIQYKDFTVWHNRLLQSDVIEKQ----------EASLAERIC 1246 Query: 1061 DYKRPVHKSYEGSKI-PFTLDKETTRKLKELAGDNGATLYMLL-------------LALF 1106 + + K PF +K+L ++L+M+ L Sbjct: 1247 RRDSSIESTDRLPKYQPF-----KALMVKDLHSVQESSLWMIYTRWQQKQEQHYIWFYLL 1301 Query: 1107 NIM--LSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVK 1164 IM LSK + Q+DI+VG+P+ R ++E+++GMF NTLA+R+ FKDFL VK Sbjct: 1302 RIMFFLSKYSGQDDIVVGTPIAGRSHADVENMLGMFVNTLAIRSRLNNEDTFKDFLANVK 1361 Query: 1165 SSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHE 1224 +AL A++N DY F+ ++ KL I RD RNPLFD M +LQN F+ ++ ++ Y Sbjct: 1362 QTALHAYENPDYPFDTLVEKLGIQRDLSRNPLFDTMFVLQNTDRKSFEVEQITITPYVPN 1421 Query: 1225 HNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISD 1284 S+FD+TL E + +L C EYCT+LF +TVE M + I++ ++ + I IS+ Sbjct: 1422 SRHSKFDLTLEVSEEQNEILLC-LEYCTKLFTDKTVERMAGHFLQILHAIVGNPTIIISE 1480 Query: 1285 ICMVSENAVQQIL-AFNQTSFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNK 1343 I ++SE Q IL FN T P + + +RR D A+ + DQT++Y ELN+ Sbjct: 1481 IEILSEEEKQHILFEFNDTKTTYPLCKQFKDYLRNRWRRRADHVAVGWKDQTLTYRELNE 1540 Query: 1344 RANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMI 1403 RANQ+AR+LR+KGV ++VGL+ ERS EM++G +GILK+GGAYLP+DP+YP +RI +MI Sbjct: 1541 RANQVARVLRQKGVQPDNIVGLLVERSPEMLVGIMGILKAGGAYLPLDPEYPADRISYMI 1600 Query: 1404 EDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTG 1463 +D G++++LTQ + + + + + L+ L D SNL +N++ DLAY++YTSG+TG Sbjct: 1601 QDCGVRIMLTQQHLLSLVHDEFDCVILDEDSLYKGDSSNLAPVNQAGDLAYIMYTSGSTG 1660 Query: 1464 KPKGTLLEHKGIVNLTASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTT 1523 KPKG ++EH+ ++ L N +++++ +R++Q +I FD ++ S+L G L T Sbjct: 1661 KPKGVMVEHRNVIRL-VKNTNYVQVREDDRIIQTGAIGFDALTFEVFGSLLHGAELYPVT 1719 Query: 1524 KEILNDNSCFEAFLNSNRITAAILPPTYLANLNPNN---IHTVDKMITIGSAISSGLVNE 1580 K++L D FL +N+IT L L+ + +I G A+S +N Sbjct: 1720 KDVLLDAEKLHKFLQANQITIMWLTSPLFNQLSQGTEEMFAGLRSLIVGGDALSPKHINN 1779 Query: 1581 WKRKCEYI---NAYGPTETTVYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQP 1637 KRKC + N YGPTE T +S+ ++ +K E DD +PIGK I N+ +YI+D+Y LQP Sbjct: 1780 VKRKCPNLTMWNGYGPTENTTFSTCFLIDK--EYDDNIPIGKAISNSTVYIMDRYGQLQP 1837 Query: 1638 VGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGR 1697 VG+PGELC+GG G+ RGY +P +T +K + + ++YRTGDLARWLPDG +EYLGR Sbjct: 1838 VGVPGELCVGGDGVARGYMNQPALTEEKFVPNPFAPGERMYRTGDLARWLPDGTIEYLGR 1897 Query: 1698 MDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELR 1757 +D+QVKIRG+R+EP EI+ L+K + +K+ ++ ++ ++CAYY+ + +V+ELR Sbjct: 1898 IDQQVKIRGYRIEPGEIETLLVKHKKVKESVIMVVEDNNGQKALCAYYVPEEEVTVSELR 1957 Query: 1758 KQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLA 1817 + + +LP +M+PAYFV++E PLT NGK+++ LP P+ + Y+ P ++IE+ LA Sbjct: 1958 EYIAKELPVYMVPAYFVQIEQMPLTQNGKVNRSALPKPDGEFGTATEYVAPSSDIEMKLA 2017 Query: 1818 EVWEEVLRLEKVGIEDNFFEVGGDSLKAM-QVAAILGKHRLHMEIKDLFHRQKIAELSEC 1876 E+W VL + K+G+ DNFFE+GG SL+AM ++ + + + + +K LF I+ L++ Sbjct: 2018 EIWHNVLGVNKIGVLDNFFELGGHSLRAMTMISQVHKEFDVELPLKVLFETPTISALAQY 2077 Query: 1877 VRDLRNNPIVENPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHL 1936 + D G +G + + + + S + + Sbjct: 2078 IAD-----------------GQKG-------MYLAIQPVTPTDYYPVSSAQKRMYILYEF 2113 Query: 1937 PAAVQKYHLMNAEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRSVIVNDGENTYFYEH 1996 A Y++ N + + D + + AI LVN LR+ +++ + Sbjct: 2114 EGAGITYNVPNVMFIEGKL------DYQRFEYAIKSLVNRHEALRT--------SFYSLN 2159 Query: 1997 GSVYNLPFILIDLS-GFDAARRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYML 2055 G ++L + A+ E ++ PF+ + L R+ LV+ A + Y+ Sbjct: 2160 GEPVQRVHQNVELQIAYSEAKEDEIEQIVESFVQ--PFDLEIAPLLRVGLVKLASDRYLF 2217 Query: 2056 LYSADHAVSDGLSLGIITDQLAAYFAGDSSLPVH----SLKHHQNYWDYADQMQK 2106 L H +SDG+S+ IIT ++A + G +H QN W +D ++K Sbjct: 2218 LMDMHHIISDGVSMQIITKEIADLYKGKELAELHIQYKDFAVWQNEWFQSDALEK 2272 Score = 508 bits (1308), Expect = e-142, Method: Compositional matrix adjust. Identities = 415/1461 (28%), Positives = 706/1461 (48%), Gaps = 148/1461 (10%) Query: 863 RDYYPMSSAQKRMYALYH--LEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILR 920 +D Y +S Q+ M L+H L+ + ++ + + +EG +DV + L +I R+++ R Sbjct: 10 QDMYRLSPMQEGM--LFHALLDKDKNAHLVQMSIAIEGIVDVELLSESLNILIDRYDVFR 67 Query: 921 TSF-HMIHHEPVQVV----------HDTIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSP 969 T+F H +P+QVV D + E+ I+ + + + FDL P Sbjct: 68 TTFLHEKIKQPLQVVLKERPVQLQFKDISSLDEEKREQAIEQYKYQDGETV--FDLTRDP 125 Query: 970 LFRVKIIKIASRHYLFMFDMHHIISDG----------ISIGLFIKELALLYGNAVLPEPE 1019 L RV I + +Y ++ HHI+ DG +I L +KE L AV P Sbjct: 126 LMRVAIFQTGKVNYQMIWSFHHILMDGWCFNIIFNDLFNIYLSLKEKKPLQLEAVQP--- 182 Query: 1020 IQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTL 1079 +K F W E D ++ +W + + LP + +YE ++ F Sbjct: 183 --YKQFIKW----LEKQDKQEALRYWKEHLMNYDQSVTLPKKKAAINNTTYEPAQFRFAF 236 Query: 1080 DKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQ--VELESVM 1137 DK T++L +A + TL ++ ++ I+L K + ++ GS V+ R +E ++ Sbjct: 237 DKVLTQQLLRIANQSQVTLNIVFQTIWGIVLQKYNSTNHVVYGSVVSGRPSEISGIEKMV 296 Query: 1138 GMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLF 1197 G+F NTL +R ++ F + + V + L + ++ + E+ + ++ ++ L Sbjct: 297 GLFINTLPLRIQTQKDQSFIELVKTVHQNVLFSQQHEYFPLYEIQNHTELKQN-----LI 351 Query: 1198 DAMLILQNIA-VNQFQFGEM--KVSFYEHEHNI---SRFDITLHCLEGLDGLLHCSFEYC 1251 D +++++N V + Q + KV F + + + +D+T+ L + + +Y Sbjct: 352 DHIMVIENYPLVEELQKNSIMQKVGFTVRDVKMFEPTNYDMTVMVLPRDE--ISVRLDYN 409 Query: 1252 TRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILAFNQTSFDLPADQT 1311 ++ + ++ + ++K + V + + + D+ ++++ Q +L S D+T Sbjct: 410 AAVYDIDFIKKIEGHMKEVALCVANNPHVLVQDVPLLTKQEKQHLLVELHDSITEYPDKT 469 Query: 1312 IHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSF 1371 IH LF EQ ++ + A+ F D+ ++Y EL++R+NQLAR LREKGV S++G+M ERS Sbjct: 470 IHQLFTEQVEKTPEHVAVVFEDEKVTYRELHERSNQLARFLREKGVKKESIIGIMMERSV 529 Query: 1372 EMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLN 1431 EM++G LGILK+GGA++PIDP+YP ERI +M++ ++LVLTQ + F E I + Sbjct: 530 EMIVGILGILKAGGAFVPIDPEYPKERIGYMLD--SVRLVLTQRHLKDKFAFTKETIVIE 587 Query: 1432 CAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDR 1491 +++ + IN S DL Y+IYTSGTTGKPKG +LEHK IVNL E+ I Sbjct: 588 DPSISHELTEEIDYINESEDLFYIIYTSGTTGKPKGVMLEHKNIVNLLHFTFEKTNINFS 647 Query: 1492 ERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTY 1551 ++V+Q+++ ++L GG L L KE D + I P + Sbjct: 648 DKVLQYTNAVLTCVTKKFFSTLLSGGQLYLIRKETQRDVEQLFDLVKRENIEVLSFPVAF 707 Query: 1552 LA---------NLNPNNIHTVDKMITIGSAISSGLVNEWKR-----KCEYINAYGPTETT 1597 L N P V +IT G + NE+KR N YGP+ET Sbjct: 708 LKFIFNEREFINRFPT---CVKHIITAGEQLVVN--NEFKRYLHEHNVHLHNHYGPSETH 762 Query: 1598 VYSSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWK 1657 V ++ I N + E+ + PIGKPI NT +YILD+ + LQP GI GEL I G + RGY Sbjct: 763 VVTTYTI-NPEAEIPELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGANVGRGYLN 821 Query: 1658 RPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAE 1717 E+TA+K ++YRTGDLARWLPDGN+E+LGR D QVKIRG R+E EI+A+ Sbjct: 822 NQELTAEKFFADPFRPNERMYRTGDLARWLPDGNIEFLGRADHQVKIRGHRIELGEIEAQ 881 Query: 1718 LLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRME 1777 LL +G+K+ +V + + +CAY + ++ + +ELR+ L LP++MIP++FV ++ Sbjct: 882 LLNCKGVKEAVVIDKADDKGGKYLCAYVVMEVEVNDSELREYLGKALPDYMIPSFFVPLD 941 Query: 1778 AFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFE 1837 L NGKID+K LP E + ++ Y+ P NE+E LA++WEEVL + ++GI+DNFF Sbjct: 942 HVRLHLNGKIDRKSLPNLEGIVNTNAKYVVPTNELEEKLAKIWEEVLGISQIGIQDNFFS 1001 Query: 1838 VGGDSLKAMQVAAILGKH-RLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSS 1896 +GG SLKA+ + + + K + + ++ LF I E+S I+ + Sbjct: 1002 LGGHSLKAITLISRMNKECNVDIPLRLLFEAPTIQEIS----------------NYINGA 1045 Query: 1897 GTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIP 1956 E +I+ + +QE S++ + + Y+L + + Sbjct: 1046 KKESYVAIQ--------PVPEQEYYPVSSVQKRMFILNEFDRSGTAYNLPGVMFLDGKLN 1097 Query: 1957 FRSCGDIGKIQKAILRLVNEQVLLRSVIVN-DGENTYFYEHGSVYNLPFILIDLSGFDAA 2015 +R +++ A+ +LV LR+ + +GE + + S D Sbjct: 1098 YR------QLEAAVKKLVERHEALRTSFHSINGEPVQRVHQNVELQIAY---SESTEDQV 1148 Query: 2016 RRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQ 2075 R ++Q PF + L R+ LV+ E ++ + H +SDG+S+ I+ + Sbjct: 1149 ERI-IAEFMQ------PFALEVRPLLRVGLVKLEAERHLFIMDMHHIISDGVSMQIMIQE 1201 Query: 2076 LAAYFAGDSSLPVHSLKHH-----QNYWDYADQMQKGPQNLSEQQLCGMFRLAAFAAQAR 2130 +A + + LP +++ N +D ++K +L+E ++C R + Sbjct: 1202 IADLYK-EKELPTLGIQYKDFTVWHNRLLQSDVIEKQEASLAE-RIC---RRDSSIESTD 1256 Query: 2131 ELEKY-----INSKNRHKSTMLDL-VIPLRLGNKEKSH--WQLALEVMIPLCGKMFGIRE 2182 L KY + K+ H L +I R K++ H W L +M K G + Sbjct: 1257 RLPKYQPFKALMVKDLHSVQESSLWMIYTRWQQKQEQHYIWFYLLRIMF-FLSKYSGQDD 1315 Query: 2183 VPFWLVNNGRRYEENLYYDIVGDFADVIPVLAGNNQTDSLEKWIQHLVNECVKGNISFVN 2242 + GR + + +++G F + + + + N D+ + ++ N+ Sbjct: 1316 IVVGTPIAGRSHAD--VENMLGMFVNTLAIRSRLNNEDTFKDFL---------ANVKQTA 1364 Query: 2243 LMLNGGTAYPFAETSRLLEKL 2263 L YPF L+EKL Sbjct: 1365 LHAYENPDYPF---DTLVEKL 1382 >sp|O68008|BACC_BACLI Bacitracin synthetase 3 (BA3) [Includes: ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); ATP-dependent D-phenylalanine adenylase (D-PheA) (D-phenylalanine activase); ATP-dependent histidine adenylase (HisA) (Histidine activase); ATP-dependent D-aspartate adenylase (D-AspA) (D-aspartate activase); ATP-dependent asparagine adenylase (AsnA) (Asparagine activase); Aspartate racemase ; Phenylalanine racemase [ATP hydrolyzing] ] pir||T31679 bacitracin synthetase 3 - Bacillus licheniformis gb|AAC06348.1| bacitracin synthetase 3; BacC [Bacillus licheniformis] Length = 6359 Score = 1325 bits (3430), Expect = 0.0, Method: Compositional matrix adjust. Identities = 732/1898 (38%), Positives = 1126/1898 (59%), Gaps = 47/1898 (2%) Query: 12 LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRLDIPDGLFQQLQHLSN 71 L + ++ + YW + + G + + + S G + +E ++ L +L L+N Sbjct: 183 LEDQDKEEAQSYWESYLSGYDQKNSLPKLRTPSETGFKRREKT-IECSKELTNRLIKLAN 241 Query: 72 RSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHYVPI-IDTFTTGMT 130 R+ ++ +L + ++ K+ S + + V ++ E V + I+T T + Sbjct: 242 RNHVTINTVLQSIWGVILAKYNNSEDVVFGT-VVSGRDAEVEGIETMVGVFINTIPTRIR 300 Query: 131 F-RESLLQ--VRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHNDAVI 187 ++ L + +R+T A + Y + + E VQA+S+ + HV+ + Sbjct: 301 LDKDKLFKDVLRQTQADALESSRYNYMNLAE-VQALSELKNDLIDHVMVFENYAVDQKAF 359 Query: 188 P---DVGSNIV---------FGFTRD---DAGISLNLIYNLKYFTRNFVMQLAKQYFQIL 232 DVG +V + F+ D + L IY+ + + L K + Sbjct: 360 EEKNDVGFEMVNVSGEEQTNYHFSISAALDDQLKLLFIYDENVYDTTIIETLEKHIITVA 419 Query: 233 KGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNM-EDMTLYELFEKQVRQTPDHVAVK 291 + AE+ + L + T +D L+ELFE+Q +TPDH A+ Sbjct: 420 EQVAEDETQTLRDINLVSKEEQHRILDTFNDTKTGYPKDKPLHELFEEQAMKTPDHTALV 479 Query: 292 FNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLPL 351 F Q +TYR+LN KAN+ AR+LR +G+G I ++ +RS +M GI+GILK+G AYLP+ Sbjct: 480 FGAQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADRSFEMIIGIIGILKAGGAYLPI 539 Query: 352 DIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDLILGRA 411 D ++P+ R+ F++ D V ++ + + + + +I LD V + S L Sbjct: 540 DPETPKHRIAFMLSDTKAGVLLAQGKAADGIDCEA-DIIHLDKGVA-DGFSKKRLSSVND 597 Query: 412 LDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEY-SFDASDRMLQLFSYIFDGFLT 470 AY+IYTSG+TG PKGV+ H S + + + + Y D +LQL +Y FDG + Sbjct: 598 SGDTAYIIYTSGSTGMPKGVVTPHYSAARVV--KNTNYIDITEDDAILQLSNYSFDGSVF 655 Query: 471 SFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEAQSL 530 F +++GA++V +++ + + ++I +++ L++ L ++ L Sbjct: 656 DIFGALLNGASLVLIEKETVLNTHELAEVIKKEQVSVMFITTALFNTLA-DINIGCLAKL 714 Query: 531 RIVTLAGEKVT-PNLLIASKQL-HPGME-IVNEYGPTESSVLATLKRDLKPDDTELTI-- 585 R + L GE+ + P++ K L H G + +++ YGPTES+V AT + DD TI Sbjct: 715 RKIFLGGERASIPHV---RKVLNHVGRDKLIHVYGPTESTVYATYYFINEIDDEAETIPI 771 Query: 586 GKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERM 645 G P+ NT V I+ + +L G+ GELCI+G GL++GYL+ E LT +KF+ +PF ER+ Sbjct: 772 GSPLANTSVLIMDEAGKLLPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERL 831 Query: 646 YRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQND 705 Y+TGDLA+W G IE IGR D QVK+RG+RIELGEIE+RL + I E +V + ED+ Sbjct: 832 YKTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDEES 891 Query: 706 NSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQD 765 ICAYI +R +S EL+ L + LPEYM+P +F ++++ P+T GK+DR AL Sbjct: 892 RPYICAYITANREISLDELKGFLGEKLPEYMIPAYFVKMDKLPLTKNGKVDRKALPEPDR 951 Query: 766 LKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQ 825 ++ P NE E +L IW+++L+V+K I+D+FF +GGHSLKA + +R+ KE + Sbjct: 952 TAGAENEYEAPRNETEEKLAAIWRDILKVEKSGINDHFFEMGGHSLKAAAMAARIRKELK 1011 Query: 826 VEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGES 885 EI L +IF+ TI L I+S + YSSI E+++YY +SSAQKR+Y L +EG Sbjct: 1012 AEIPLGQIFKTPTIKGLGEYIRSTKDSVYSSIQKVEEKEYYRLSSAQKRLYILDQIEGSG 1071 Query: 886 TSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYT 945 SYN+P M ++G D+ + E+ L+ +I RHE LRTSF M EPVQ + +DFSI + Sbjct: 1072 LSYNIPFTMKVKGRFDIRRFENALKTIIQRHEALRTSFLMADGEPVQKIEKEVDFSIKCS 1131 Query: 946 EEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKE 1005 + + I+ +F++PFDL +PLFR +++K+ ++ +FDMHHIISDG S+G+ KE Sbjct: 1132 KIQSLSIQEIIKQFVRPFDLKKAPLFRTEVVKVDDEEHIILFDMHHIISDGASMGVLTKE 1191 Query: 1006 LALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRP 1065 + LYG L +Q+KD+S W+++ + + K+Q+E+WL +FKGE+P+L +P DY RP Sbjct: 1192 ICDLYGGKELKPLSLQYKDYSEWQRDFYQKDEMKRQKEYWLNIFKGEIPVLNMPTDYPRP 1251 Query: 1066 VHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPV 1125 S EG +I F +D E T+KLK +A DNGAT+YMLLLA + ++L + QED+I+G+P+ Sbjct: 1252 QMHSVEGDRIGFAIDGELTKKLKRIAKDNGATMYMLLLAAYTVLLRTYSGQEDVIIGTPI 1311 Query: 1126 TRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKL 1185 R+ EL+ V+GMF NTLAMRN P G+K F ++L +VK +AL A++NQDYQF++++ +L Sbjct: 1312 QGRKHHELKHVIGMFVNTLAMRNHPKGDKTFAEYLQDVKETALKAYENQDYQFDDLVEQL 1371 Query: 1186 DIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLH 1245 D+ RD RNPLFD M +LQN+ + + +E + +IS+FD+TL +E D + Sbjct: 1372 DLERDMSRNPLFDTMFVLQNLEKADAEIEGLTFEPFESDIHISKFDLTLSAIEK-DSKIE 1430 Query: 1246 CSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSF 1304 EYCT+LFKRETVE M + ++ + + R+ I +SE+ +L FN T Sbjct: 1431 FDLEYCTKLFKRETVERMAAHFVRVLEDISKRTDKRLDQIEAMSEDEKNTLLYRFNDTKT 1490 Query: 1305 DLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVG 1364 D P D+TI LF E+A+ D+ A+ F DQT++Y +L++R+NQLAR LREKGV + VG Sbjct: 1491 DAPTDKTICQLFAERAETSPDKTAVVFEDQTLTYRQLHERSNQLARFLREKGVQPDTAVG 1550 Query: 1365 LMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFD 1424 +M +RS EM+IG LGILK+GGAYLP+DP YP +RIK+++ DS + +L++ F Sbjct: 1551 IMVDRSPEMIIGLLGILKAGGAYLPLDPAYPEDRIKYILGDSQTKFLLSEEALIKKRAFI 1610 Query: 1425 GEV----IDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTA 1480 E ID++ + D + L ++RS DLAY+IYTSG+TGKPKG L+E KG+ NL + Sbjct: 1611 KEADMINIDIHDKQIAAQDAAQLEPVSRSGDLAYIIYTSGSTGKPKGVLIEQKGLSNLVS 1670 Query: 1481 SNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSN 1540 + + + + RV+QF+S+SFD S +I ++ G L L +E + +FL Sbjct: 1671 AVVKLMHLNTGSRVIQFASLSFDASAFEIFPALAAGSALVLGRQEEMMPGQPLTSFLRQY 1730 Query: 1541 RITAAILPPTYLANLNPNNIHTVDKMITIGSAISSGLVNEWKRKCEYINAYGPTETTVYS 1600 IT A LPPT L LN + + + +++ GSA S L W +INAYGPTETTV + Sbjct: 1731 NITHATLPPTVLDVLNESGLENLKVIVSAGSACSEELAKRWSGNRLFINAYGPTETTVCA 1790 Query: 1601 SVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPE 1660 + I G IG PI NT +Y+LD+ + P G+ GELC+GG+ L RGY RPE Sbjct: 1791 TAGIYEGSGRPH----IGSPIANTNVYVLDQNQKPVPTGVVGELCVGGMSLARGYLNRPE 1846 Query: 1661 MTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLK 1720 +TA+K I+ + ++YRTGDLARWLPDG+LE+LGR+D QVKIRG+R+E EI+ +LLK Sbjct: 1847 LTAEKFISHPFASGERLYRTGDLARWLPDGHLEFLGRIDHQVKIRGYRIELGEIENQLLK 1906 Query: 1721 IEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFP 1780 ++ I + V RK+ +CAY +S D++ TE+ + L +LP +MIPAYFVR++ P Sbjct: 1907 LDKIDEAAVIARKDDDHSDYLCAYIVSKEDWTSTEISEWLEKELPHYMIPAYFVRLDKLP 1966 Query: 1781 LTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGG 1840 LTSN K+D+K LP P+ + + Y PRN+ E L ++W +VL +GI +FF GG Sbjct: 1967 LTSNDKVDRKALPAPDRHVATGAVYEAPRNDTEAKLVDIWRDVLGAGDIGISHHFFAAGG 2026 Query: 1841 DSLKAMQVAAILGKHRLHMEIKDLFHRQKIAELSECVR 1878 DS+KA+Q+ + L + L +E+KDLF +I +L++ V+ Sbjct: 2027 DSIKALQIVSRLSRLGLKLEMKDLFANPRIKDLAKYVK 2064 Score = 1311 bits (3392), Expect = 0.0, Method: Compositional matrix adjust. Identities = 769/2154 (35%), Positives = 1213/2154 (56%), Gaps = 112/2154 (5%) Query: 12 LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRLDIPDGLFQQLQHLSN 71 L + ++ ++YW + G E +++ T + + + + L +QL+ L+ Sbjct: 2722 LERQDQEEARQYWREYLKGYEEQAQLPTLTKRKKSSRYDRREKVIHLSKQLTKQLKELAA 2781 Query: 72 RSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHYVPIIDTFTTGMTF 131 ++ +L+ ++ T ++ ++T+ + + V E + + I+T T + F Sbjct: 2782 KNSVTLHTVIQTIWGLMLTRYTKIDDVVFGTVVSGREANVDGIEDMIGLFINTIPTRIRF 2841 Query: 132 RES------LLQVRETTLGA--YDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN 183 E L +V+E + + Y++ + + +VQA+S + H+L + Sbjct: 2842 NEQARFNDCLQKVQEDAIQSNRYNYMN------LAEVQALSSLKKDLIDHILVFENYEAD 2895 Query: 184 DAVIPDVGSNIVFGFTRDDAG------------------ISLNLIYNLKYFTRNFVMQLA 225 + + S + GF ++ ++L L Y+ + R+ + + Sbjct: 2896 EQDFEE--SQMKTGFKVNEISAAEQSITAFSMSVTPGEELTLVLTYDGNVYDRDIINNIE 2953 Query: 226 KQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNM-EDMTLYELFEKQVRQT 284 ++ + N + K+ + RT + + T+++LFE+Q +T Sbjct: 2954 GHIKRVAEQVTANENRKIAEIDMLAEEERKTLLYEFNRTNADYPRNKTIHQLFEEQAERT 3013 Query: 285 PDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKS 344 P H AV F + ++Y+ LN ++N+LA +LR +GV + IVG++ ERS++M G+L +LK+ Sbjct: 3014 PGHTAVVFEKEELSYKALNERSNQLAGLLREKGVKPDMIVGVMAERSVEMIVGMLAVLKA 3073 Query: 345 GAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDL 404 G AYLP+D + PE+R++++IED+GI + + K+ ++++ D T I +++ L ++ + Sbjct: 3074 GGAYLPIDPEYPEDRIRYMIEDSGISILL--KKADKQIDVD-FTCIDMNEKGLAKDMAAE 3130 Query: 405 DLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYI 464 +L AYVIYTSG+TG+PKGV++ H+SI NT+ WRK Y + +D LQ+ S+ Sbjct: 3131 NLGHTSGSSDMAYVIYTSGSTGKPKGVMVNHQSIVNTLYWRKQSYGYSTADATLQVPSFS 3190 Query: 465 FDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKP 524 FD + FT ++SGA +V + + +P II ++ HK T+ +AVP+ Y LL ++ Sbjct: 3191 FDSSVEDIFTTLISGAKLVLIRDLRM-NPREIIGVLRTHKATNLLAVPSFYLNLLDTIE- 3248 Query: 525 EEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELT 584 + LR VT+AGE +L+ + P +++ NEYGPTE+SV +T + +L+ DD ++ Sbjct: 3249 QPLDDLRFVTVAGEGFNESLIRQHFEKLPNVKLFNEYGPTENSVCST-RGELRKDDEKVV 3307 Query: 585 IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANER 644 IG+PI N +VYI+ N +L G GELC+SG GLARGYL+ LT +KFV NPF E Sbjct: 3308 IGRPISNHKVYILNHNQQLLPLGTPGELCLSGEGLARGYLNRPDLTLEKFVPNPFAPGES 3367 Query: 645 MYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQN 704 MYRTGDLAR+ G+IE +GR D QVK+RG+RIELGEIEN+LL+ GI A V EDQ Sbjct: 3368 MYRTGDLARFLPDGQIEYLGRIDHQVKIRGFRIELGEIENQLLKIEGIDAAAVMAREDQA 3427 Query: 705 DNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNAL-RNN 763 +CAYIV D+ ++R+ L K LP+YM+P++F +L+Q P+T GK+DR AL + Sbjct: 3428 GGKYLCAYIVADKAAGVADVRKCLLKELPDYMVPSYFVKLDQLPLTANGKIDRKALPEPS 3487 Query: 764 QDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKE 823 + E A ++ P N E +LV IW++VL ++ + I NFF LGGHSLKA L ++LHKE Sbjct: 3488 STISE--ATYEAPRNRTEEKLVSIWEDVLGIENIGISHNFFELGGHSLKAAALTAKLHKE 3545 Query: 824 FQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEG 883 ++E+ L ++FE TI ++ I+S + Y+SI E+++YY +SSAQ+R+Y L +E Sbjct: 3546 MKIEVPLRQLFETPTIKDIGDFIESMKESPYASITQAEEKEYYALSSAQRRLYILNQIEP 3605 Query: 884 ESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSID 943 SYNMP M + G+ DV + E RQ+I RHE LRT+F M+ EPVQ + +DF + Sbjct: 3606 GGLSYNMPFAMKIAGDFDVDRFEDAFRQLIERHEALRTAFVMVDGEPVQKIEKEVDFKVK 3665 Query: 944 YTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFI 1003 Y D + + FI+PF L+ +PL R +++K + ++ M DMHHIISDG+S+ +F Sbjct: 3666 YGRLGQDPLEEKIKAFIKPFALEKAPLLRAEVLKASGDEHVLMLDMHHIISDGVSMAIFT 3725 Query: 1004 KELALLYGNAVLPEPEIQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYK 1063 +ELA LY LP IQ+KDFS W+K + + K+QE++WL +F+GEVP+L LP D K Sbjct: 3726 RELAELYEGKTLPPLTIQYKDFSEWQKLFYQKDEVKRQEDYWLNVFQGEVPVLNLPADEK 3785 Query: 1064 RPVHKSYEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGS 1123 RP +S EG + F +D ET+ L +LA +NGAT+YMLLLA + +L+K T QEDI+VGS Sbjct: 3786 RPQKRSIEGDIVQFEIDGETSAMLNKLAKENGATMYMLLLAGYTTLLAKYTGQEDIVVGS 3845 Query: 1124 PVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMIS 1183 P+ R +L+ V+G+F NTLAMRN P G+ F D+L EVK +AL A++NQDY F+E++ Sbjct: 3846 PIAGRHHSDLKHVIGLFINTLAMRNHPKGDMPFADYLKEVKETALKAYENQDYPFDELVE 3905 Query: 1184 KLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGL 1243 KLD+ RD R+PLFD ML+LQN ++ + + E NIS+FD+TL E +G Sbjct: 3906 KLDVKRDMSRHPLFDTMLVLQNFDGDEADIDGLTFQPLQTEVNISKFDLTLTAAETNEG- 3964 Query: 1244 LHCSFEYCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILAFNQ-T 1302 + C F Y T+LFKR T+E M +L I+ + D + +SD+ M+S+ + +L NQ Sbjct: 3965 IQCVFNYSTKLFKRSTIERMAGHLINILKEAANDPHMPLSDVNMLSDEEMNALLDQNQGK 4024 Query: 1303 SFDLPADQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSV 1362 D P DQT+H LFE+QA + ++ A+ + D+ ++Y ELN+RANQLARLLR+KG A Sbjct: 4025 QADYPQDQTVHQLFEQQADKTPEQTAVVYADEKLTYRELNERANQLARLLRDKGADADQP 4084 Query: 1363 VGLMFERSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLD 1422 V +M E S EM+I L +LK+G AY+PI+P+ +R ++ DS ++L + + Sbjct: 4085 VAIMIEPSLEMIISMLAVLKAGAAYVPIEPEQLAKRTNEILSDSRAAILLVKGSVKENVA 4144 Query: 1423 FDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASN 1482 F GE++++ ++ SNL + AY+IYTSG+TGKPKG + H +VN T Sbjct: 4145 FAGEIVNVADGLIDAKVASNLSASGSADQNAYIIYTSGSTGKPKGVFVRHGNVVNYTTWF 4204 Query: 1483 KEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRI 1542 ++ + + ++ + SS +FD+ I ++L G L + KE + ++ N I Sbjct: 4205 MKEAGLTENDKAMLVSSYAFDLGYTSIFSALLSGSELHIARKECYTNAHRALKYIKENGI 4264 Query: 1543 TAAILPPTYLANLNPNN--------IHTVDKMITIGSAISSGLVNEWKRKCE---YINAY 1591 T L P+ L N+ N+ T+ ++ G I++ V + + +N Y Sbjct: 4265 TYIKLTPS-LFNIFVNDPGFSAEKPCATLRLVVLGGEMINTRDVETFYNQYPDHVVMNHY 4323 Query: 1592 GPTETTVYSSVWIANKQGEVDD----PVPIGKPILNTQMYILDKYRNLQPVGIPGELCIG 1647 GPTETT+ S + + + +D PV IG PI NT Y+LD+ L P G+ GELCI Sbjct: 4324 GPTETTIGSVFKVIDPE-HLDSFKECPV-IGTPIHNTNAYVLDENMKLLPEGVYGELCIA 4381 Query: 1648 GIGLTRGYWKRPEMTADKIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGF 1707 G G+T GY RP+ T +K I + K+YRTGDLAR L DGN+E GR+D QVK+RG+ Sbjct: 4382 GAGVTGGYVNRPDETKEKFIENPFAPHTKMYRTGDLARRLSDGNIELAGRIDTQVKVRGY 4441 Query: 1708 RVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEF 1767 R+EP+EIK LL + IK+ + R++ +CAY+ + + ++R L+ +LPE+ Sbjct: 4442 RIEPEEIKNRLLAHDDIKEAFIAAREDHKGAKQLCAYFTADAELPFEDIRTYLMHELPEY 4501 Query: 1768 MIPAYFVRMEAFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLE 1827 MIP+ FV++E PL++NGKID LP P+ + + Y PPRNE E L ++WEEVL ++ Sbjct: 4502 MIPSSFVQIEKMPLSANGKIDTAALPEPQPG--KETEYEPPRNETEEKLVQIWEEVLGID 4559 Query: 1828 KVGIEDNFFEVGGDSLKAMQVAAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVE 1887 K+GI +FF GGDS+KA+Q+ + L + L +E+KDLF +I LS V+ Sbjct: 4560 KIGITHHFFAAGGDSIKALQMISRLSREGLSLEMKDLFANPQIKSLSRYVK--------- 4610 Query: 1888 NPVGRIDSSGTEGDASIEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMN 1947 D S + EVL L I+ + ++ RN H AV Y Sbjct: 4611 ---AESDKSASYETVEGEVL----LTPIQQEYFSLNKTDRN------HYNHAVMLYR--- 4654 Query: 1948 AEKVHTSIPFRSCGDIGKIQKAILRLVNEQVLLRSVIVNDGENTYFYEHGSVYNLPFILI 2007 ++ D +++ ++ LR+V + Y G L Sbjct: 4655 ----------KNGFDESIVKRVFKEIIKHHDALRTVFTEEDGKIIQYNRGPDKQ----LF 4700 Query: 2008 DLSGFDAARRSECLAYLQDHFNKL--PFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSD 2065 DL +D + ++ + +L + + G L +L + +T D++L+ H V D Sbjct: 4701 DLFVYDVSSENDQPQKVYQLATELQQSIDIETGPLVKLAVFKTNNGDHLLII-IHHLVVD 4759 Query: 2066 GLSLGIITDQLAAYFA----GDSSLPVHSLKHHQNYWDYADQMQKGPQNLSEQQ 2115 G+S I+ + LA ++ G+ +Q Y + + K + LSE+Q Sbjct: 4760 GISWRILFEDLAIGYSQLANGEKVEFYPKTASYQAYARHIAEYAKSVKLLSEKQ 4813 Score = 619 bits (1596), Expect = e-175, Method: Compositional matrix adjust. Identities = 413/1258 (32%), Positives = 672/1258 (53%), Gaps = 97/1258 (7%) Query: 866 YPMSSAQKRMYALYHLEGESTS--YNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSF 923 YP+++ QK M L+H + TS Y VM +EG +D +E+ ++ RHEILR S+ Sbjct: 2545 YPLANMQKGM--LFHAIEDHTSDAYFQQTVMDIEGYVDPAILEASFNDIMKRHEILRASY 2602 Query: 924 -HMIHHEPVQVV--HDTIDF-------SIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRV 973 + I EP Q++ + +IDF S +E + L DR + FDL L R Sbjct: 2603 EYEIVEEPRQIIIENRSIDFTYFNIAKSSAQQQEMFIERLLNEDR-KKGFDLSKDVLMRA 2661 Query: 974 KIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLYGN----AVLPEPEIQ-FKDFSVW 1028 ++K A R Y ++ HHI+ DG +G+ ++EL ++Y N P E + + D+ W Sbjct: 2662 YLLKTAERSYRLVWSHHHILLDGWCLGIIMRELFVIYENRMNGKASPLKETKPYSDYIKW 2721 Query: 1029 EKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLK 1088 E D ++ ++W + KG +LP KR Y+ + L K+ T++LK Sbjct: 2722 ----LERQDQEEARQYWREYLKGYEEQAQLPTLTKRKKSSRYDRREKVIHLSKQLTKQLK 2777 Query: 1089 ELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVT-RRRQVE-LESVMGMFSNTLAM 1146 ELA N TL+ ++ ++ +ML++ T +D++ G+ V+ R V+ +E ++G+F NT+ Sbjct: 2778 ELAAKNSVTLHTVIQTIWGLMLTRYTKIDDVVFGTVVSGREANVDGIEDMIGLFINTIPT 2837 Query: 1147 RNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNI 1206 R RF D L +V+ A+ + E+ + + +D L D +L+ +N Sbjct: 2838 RIRFNEQARFNDCLQKVQEDAIQSNRYNYMNLAEVQALSSLKKD-----LIDHILVFENY 2892 Query: 1207 AVNQ--FQFGEMKVSFYEHEHNISRFDITLHCLEGLDGL-LHCSFEYCTRLFKRETVETM 1263 ++ F+ +MK F +E + + IT + G L Y ++ R+ + + Sbjct: 2893 EADEQDFEESQMKTGFKVNEISAAEQSITAFSMSVTPGEELTLVLTYDGNVYDRDIINNI 2952 Query: 1264 IDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLPADQTIHGLFEEQAKR 1322 ++K + QV A+ +I++I M++E + +L FN+T+ D P ++TIH LFEEQA+R Sbjct: 2953 EGHIKRVAEQVTANENRKIAEIDMLAEEERKTLLYEFNRTNADYPRNKTIHQLFEEQAER 3012 Query: 1323 RGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILK 1382 A+ F + +SY LN+R+NQLA LLREKGV +VG+M ERS EM++G L +LK Sbjct: 3013 TPGHTAVVFEKEELSYKALNERSNQLAGLLREKGVKPDMIVGVMAERSVEMIVGMLAVLK 3072 Query: 1383 SGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGL-NNMDGS 1441 +GGAYLPIDP+YP +RI++MIEDSGI ++L + +D D ID+N GL +M Sbjct: 3073 AGGAYLPIDPEYPEDRIRYMIEDSGISILLKK--ADKQIDVDFTCIDMNEKGLAKDMAAE 3130 Query: 1442 NLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRERVVQFSSIS 1501 NL + SSD+AY+IYTSG+TGKPKG ++ H+ IVN K+ + +Q S S Sbjct: 3131 NLGHTSGSSDMAYVIYTSGSTGKPKGVMVNHQSIVNTLYWRKQSYGYSTADATLQVPSFS 3190 Query: 1502 FDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYLANLNPNNIH 1561 FD S+ DI +++ G L L +N L +++ T + P++ NL Sbjct: 3191 FDSSVEDIFTTLISGAKLVLIRDLRMNPREII-GVLRTHKATNLLAVPSFYLNLLDTIEQ 3249 Query: 1562 TVD--KMITI-GSAISSGLVNEWKRK---CEYINAYGPTETTVYSSVWIANKQGEV---D 1612 +D + +T+ G + L+ + K + N YGPTE +V S+ +GE+ D Sbjct: 3250 PLDDLRFVTVAGEGFNESLIRQHFEKLPNVKLFNEYGPTENSVCST------RGELRKDD 3303 Query: 1613 DPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADS 1672 + V IG+PI N ++YIL+ + L P+G PGELC+ G GL RGY RP++T +K + + Sbjct: 3304 EKVVIGRPISNHKVYILNHNQQLLPLGTPGELCLSGEGLARGYLNRPDLTLEKFVPNPFA 3363 Query: 1673 RIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHR 1732 +YRTGDLAR+LPDG +EYLGR+D QVKIRGFR+E EI+ +LLKIEGI V R Sbjct: 3364 PGESMYRTGDLARFLPDGQIEYLGRIDHQVKIRGFRIELGEIENQLLKIEGIDAAAVMAR 3423 Query: 1733 KNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLL 1792 ++Q +CAY ++ V ++RK LL +LP++M+P+YFV+++ PLT+NGKID+K L Sbjct: 3424 EDQAGGKYLCAYIVADKAAGVADVRKCLLKELPDYMVPSYFVKLDQLPLTANGKIDRKAL 3483 Query: 1793 PVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQVAAIL 1852 P P +++ + Y PRN E L +WE+VL +E +GI NFFE+GG SLKA + A L Sbjct: 3484 PEPSSTIS-EATYEAPRNRTEEKLVSIWEDVLGIENIGISHNFFELGGHSLKAAALTAKL 3542 Query: 1853 GKH-RLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSSGTEGDASIEVLCSIW 1911 K ++ + ++ LF I ++ + + ++ +P ASI Sbjct: 3543 HKEMKIEVPLRQLFETPTIKDIGDFIESMKESPY----------------ASIT------ 3580 Query: 1912 LGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIPFRSCGDIGKIQKAIL 1971 + +++E S + + + Y++ A K+ D+ + + A Sbjct: 3581 --QAEEKEYYALSSAQRRLYILNQIEPGGLSYNMPFAMKIAGDF------DVDRFEDAFR 3632 Query: 1972 RLVNEQVLLRSVIVN-DGENTYFYEHGSVYNLPFILIDLSGFDAARRSECLAYLQDHFNK 2030 +L+ LR+ V DGE E + + + + + + A+++ Sbjct: 3633 QLIERHEALRTAFVMVDGEPVQKIEKEVDFKVKYGRLGQDPLE----EKIKAFIK----- 3683 Query: 2031 LPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQLAAYFAGDSSLPV 2088 PF + L R +++ + ++++L+ H +SDG+S+ I T +LA + G + P+ Sbjct: 3684 -PFALEKAPLLRAEVLKASGDEHVLMLDMHHIISDGVSMAIFTRELAELYEGKTLPPL 3740 Score = 616 bits (1588), Expect = e-174, Method: Compositional matrix adjust. Identities = 415/1287 (32%), Positives = 674/1287 (52%), Gaps = 116/1287 (9%) Query: 858 LPTEKRDYYPMSSAQKRMYALYHLEGESTSYNMPEVMVME--GELDVGQVESVLRQMISR 915 + T+ YP+S+ QK M L+H + S+ E ++E G++D E L +++ R Sbjct: 1 MKTKVEKIYPLSNMQKGM--LFHAMKDEASHAYFEQFIIELKGDVDERMFEESLNEVMKR 58 Query: 916 HEILRTSFHMIHHEPVQVV-------HDTIDFSIDYTEEKIDDIRLEADRFIQPFDLDTS 968 HEILR SFH EP+ V+ D +D + ++ + + L DR + FDL Sbjct: 59 HEILRASFHHRLDEPLHVIIKDRHMKFDYLDIRGRHDQDGVLERYLAEDR-QKGFDLAKD 117 Query: 969 PLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLY------GNAVLPEPEIQF 1022 L R +I+++ Y F++ HHI+ DG +G+ + EL +Y N L +P + Sbjct: 118 TLMRACLIRMSDDSYQFVWTYHHILLDGWCLGIILDELLTIYEMKRKGQNHQLEDPR-PY 176 Query: 1023 KDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKE 1082 D+ W E+ D ++ + +W G LP + P ++ + KE Sbjct: 177 SDYIKW----LEDQDKEEAQSYWESYLSGYDQKNSLP-KLRTPSETGFKRREKTIECSKE 231 Query: 1083 TTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVT-RRRQVE-LESVMGMF 1140 T +L +LA N T+ +L +++ ++L+K N ED++ G+ V+ R +VE +E+++G+F Sbjct: 232 LTNRLIKLANRNHVTINTVLQSIWGVILAKYNNSEDVVFGTVVSGRDAEVEGIETMVGVF 291 Query: 1141 SNTLAMRNFPAGNKRFKDFLNEVKSSAL--SAFDNQDYQFEEMISKLDIVRDTGRNPLFD 1198 NT+ R +K FKD L + ++ AL S ++ + + +S+L +N L D Sbjct: 292 INTIPTRIRLDKDKLFKDVLRQTQADALESSRYNYMNLAEVQALSEL-------KNDLID 344 Query: 1199 AMLILQNIAVNQFQFGEMKVSFYE------HEHNISRFDITLHCLEGLDGLLHCSFEYCT 1252 +++ +N AV+Q F E +E E F I+ LD L F Y Sbjct: 345 HVMVFENYAVDQKAFEEKNDVGFEMVNVSGEEQTNYHFSISA----ALDDQLKLLFIYDE 400 Query: 1253 RLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLPADQT 1311 ++ +ET+ ++ + QV D + DI +VS+ +IL FN T P D+ Sbjct: 401 NVYDTTIIETLEKHIITVAEQVAEDETQTLRDINLVSKEEQHRILDTFNDTKTGYPKDKP 460 Query: 1312 IHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSF 1371 +H LFEEQA + D AL F Q M+Y ELN++ANQ ARLLREKG+ GS+ ++ +RSF Sbjct: 461 LHELFEEQAMKTPDHTALVFGAQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADRSF 520 Query: 1372 EMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLN 1431 EM+IG +GILK+GGAYLPIDP+ P RI FM+ D+ ++L Q + +D + ++I L+ Sbjct: 521 EMIIGIIGILKAGGAYLPIDPETPKHRIAFMLSDTKAGVLLAQGKAADGIDCEADIIHLD 580 Query: 1432 CAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDR 1491 + L +N S D AY+IYTSG+TG PKG + H + N + I + Sbjct: 581 KGVADGFSKKRLSSVNDSGDTAYIIYTSGSTGMPKGVVTPHYSAARVV-KNTNYIDITED 639 Query: 1492 ERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTY 1551 + ++Q S+ SFD S+ DI ++L G +L L KE + + + +++ + Sbjct: 640 DAILQLSNYSFDGSVFDIFGALLNGASLVLIEKETVLNTHELAEVIKKEQVSVMFITTAL 699 Query: 1552 LANLNPNNIHTVDKM--ITIGSAISS-----GLVNEWKRKCEYINAYGPTETTVYSSVWI 1604 L NI + K+ I +G +S ++N R + I+ YGPTE+TVY++ + Sbjct: 700 FNTLADINIGCLAKLRKIFLGGERASIPHVRKVLNHVGRD-KLIHVYGPTESTVYATYYF 758 Query: 1605 ANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTAD 1664 N+ + + +PIG P+ NT + I+D+ L P+G+PGELCI G GL++GY R E+TA+ Sbjct: 759 INEIDDEAETIPIGSPLANTSVLIMDEAGKLLPIGVPGELCIAGDGLSKGYLNREELTAE 818 Query: 1665 KIITAADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGI 1724 K I ++Y+TGDLA+WLPDGN+E++GR+D QVKIRGFR+E EI++ L E I Sbjct: 819 KFIPHPFIPGERLYKTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDI 878 Query: 1725 KDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSN 1784 + IVT R+++ ICAY + + S+ EL+ L KLPE+MIPAYFV+M+ PLT N Sbjct: 879 NETIVTVREDEESRPYICAYITANREISLDELKGFLGEKLPEYMIPAYFVKMDKLPLTKN 938 Query: 1785 GKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLK 1844 GK+D+K LP P+ + + Y PRNE E LA +W ++L++EK GI D+FFE+GG SLK Sbjct: 939 GKVDRKALPEPDRTAGAENEYEAPRNETEEKLAAIWRDILKVEKSGINDHFFEMGGHSLK 998 Query: 1845 AMQVAAILGKH-RLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSSGTEGDAS 1903 A +AA + K + + + +F I L E +R +++ Sbjct: 999 AAAMAARIRKELKAEIPLGQIFKTPTIKGLGEYIRSTKDS-------------------- 1038 Query: 1904 IEVLCSIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMN---AEKVHTSIPF--- 1957 V SI Q++ E R L +A ++ ++++ + +IPF Sbjct: 1039 --VYSSI-------QKVEEKEYYR--------LSSAQKRLYILDQIEGSGLSYNIPFTMK 1081 Query: 1958 -RSCGDIGKIQKAILRLVNEQVLLR-SVIVNDGENTYFYEHGSVYNLPFILIDLSGFDAA 2015 + DI + + A+ ++ LR S ++ DGE E +D S + Sbjct: 1082 VKGRFDIRRFENALKTIIQRHEALRTSFLMADGEPVQKIEKE---------VDFSIKCSK 1132 Query: 2016 RRSECLAYLQDHFNKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQ 2075 +S + + F + PF+ L+R +V+ E++++L+ H +SDG S+G++T + Sbjct: 1133 IQSLSIQEIIKQFVR-PFDLKKAPLFRTEVVKVDDEEHIILFDMHHIISDGASMGVLTKE 1191 Query: 2076 LAAYFAGDSSLPVHSLKHHQNYWDYAD 2102 + + G P+ SL+ Y DY++ Sbjct: 1192 ICDLYGGKELKPL-SLQ----YKDYSE 1213 Score = 513 bits (1320), Expect = e-143, Method: Compositional matrix adjust. Identities = 327/1045 (31%), Positives = 562/1045 (53%), Gaps = 49/1045 (4%) Query: 866 YPMSSAQKRMYALYHL--EGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSF 923 YP+++ Q+ M L+H + ES +Y + M+G +D ++ RHEILR S Sbjct: 5092 YPLANMQRGM--LFHALEDKESQAYFEQMAINMKGLIDERLFAETFNDIMERHEILRASI 5149 Query: 924 -HMIHHEPVQVVHDTIDFSIDYTE---------EKIDDIRLEADRFIQPFDLDTSPLFRV 973 + I EP V+ ++DY + E++ +ADR + F L++ PL R Sbjct: 5150 EYEITDEPRNVIIKDRKINLDYHDLRKQSPAEREQVIQAYRKADRE-KGFRLNSEPLIRA 5208 Query: 974 KIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLYGNAVLP-----EPEIQFKDFSVW 1028 +++ Y F++ HHI+ DG S G+ + EL +Y E + D+ W Sbjct: 5209 ALMRTEDDSYTFIWTNHHILLDGWSRGIIMGELFHMYHMKEARQKHRLEEARPYSDYIGW 5268 Query: 1029 EKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLK 1088 ++ D + + +W G + V H Y+ + ++ T ++ Sbjct: 5269 LQQQ----DKEAAKAYWRNYLSGFTEKSPISVLAGSSGHAKYKRKEAVIEFPEQLTGRIT 5324 Query: 1089 ELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVT-RRRQVE-LESVMGMFSNTLAM 1146 ELA N T + +L ++ ++L++ +D++ G+ ++ R QV +E ++G+F NT+ Sbjct: 5325 ELASRNNVTFHTVLQCIWGMLLARYNQTDDVVFGTVISGRDAQVTGIEKMVGLFINTVPT 5384 Query: 1147 RNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNI 1206 R ++ FK+ + V+ AL D E+ S ++ R+ L D +LI +N Sbjct: 5385 RIRLDKSQSFKELIKSVQEQALEGRTYHDMNLSEVQSLSELKRE-----LLDHILIFENY 5439 Query: 1207 AVNQFQF---GEMKVSF-YEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVET 1262 AV+Q F G+ F +E H + + + + L Y ++ + Sbjct: 5440 AVDQSAFETSGKRGAGFVFEEIHAEEQTNYGFNIVAVPGERLVIKLTYDGNIYHDHIIAG 5499 Query: 1263 MIDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLPADQTIHGLFEEQAK 1321 + +L+ ++ QV+ + ++DI ++SE ++L +N T + P +QTIH LFEEQA+ Sbjct: 5500 IKGHLQQVMEQVVQHEDQSLNDITVLSEAERNRLLYEWNDTKAEYP-NQTIHRLFEEQAE 5558 Query: 1322 RRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGIL 1381 + + A+ + ++Y ELN+++NQLAR LR+KGV A ++V +M ERS EM++G +GIL Sbjct: 5559 KTPELAAVVSGNDKLTYRELNEKSNQLARYLRDKGVKADTIVAIMAERSPEMVVGIMGIL 5618 Query: 1382 KSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNNMDGS 1441 K+GGAYLPIDPDYP ERIK+M+EDSG ++L + + E ++L ++ Sbjct: 5619 KAGGAYLPIDPDYPEERIKYMLEDSGAAIILADH-KQDLGTLHQEAVEL-TGDFSSYPAD 5676 Query: 1442 NLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVN-LTASNKEQLKIQDRERVVQFSSI 1500 NL + LAY+IYTSG+TGKPKG ++ +G+VN +T +++ ++ + + + +SSI Sbjct: 5677 NLEPAGNADSLAYIIYTSGSTGKPKGVMIRQRGLVNYITWADRVYVQGEQLDFAL-YSSI 5735 Query: 1501 SFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYLANLNPNNI 1560 +FD+++ I + L+ G + + + + L P++L+ + + Sbjct: 5736 AFDLTVTSI-FTPLISGNRVIVYRHSEDGEPLIRKVFRDQKAGIVKLTPSHLSLVKDMDA 5794 Query: 1561 H--TVDKMITIGSAISSGLVNE----WKRKCEYINAYGPTETTVYSSVWIANKQGEVDDP 1614 ++ ++I G + + L E + E N YGPTET V ++ + + Sbjct: 5795 SGSSIKRLIVGGEDLKTELAKEITERFHHNIEIYNEYGPTETVVGCMIYQYDAGWDRQVS 5854 Query: 1615 VPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRI 1674 VPIGKP N Q+YILD+ + +QPVGI GEL I G G+ +GY +PE+T++K + Sbjct: 5855 VPIGKPASNVQLYILDERQEVQPVGIAGELYISGDGVAKGYLNKPELTSEKFLPNPFLPG 5914 Query: 1675 GKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKN 1734 ++YRTGDLA+ PDG++EYLGR+D QVKIRG+R+E EI+ +LL+ IK+ V + + Sbjct: 5915 ERMYRTGDLAKMRPDGHIEYLGRIDHQVKIRGYRIELGEIEHQLLRHSDIKEAAVAAKTD 5974 Query: 1735 QLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPV 1794 Q +CAY +S D + +++ L +LPE+M+P+Y ++++ PLT NGK+D K LP Sbjct: 5975 QNNDQVLCAYVVSERDITQKDIKTFLAKELPEYMVPSYLLKLDELPLTPNGKVDLKALPE 6034 Query: 1795 PENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQ-VAAILG 1853 P+ S Y PPR+E+E +A +WE++L +E++GI N F++G +SL M V+ + Sbjct: 6035 PDRSAGALLEYEPPRHELEEKMAAIWEDILNIEQIGINANIFDIGANSLNVMSFVSRLYA 6094 Query: 1854 KHRLHMEIKDLFHRQKIAELSECVR 1878 + + KD+F + I ELS+ ++ Sbjct: 6095 ELGFRVPFKDIFSKPTIKELSDFLK 6119 Score = 480 bits (1235), Expect = e-133, Method: Compositional matrix adjust. Identities = 328/1126 (29%), Positives = 572/1126 (50%), Gaps = 83/1126 (7%) Query: 16 EMKKKKKYWLNRVVGSETDSRILTD---PHKSALGIEGKESLRLDIPDGLFQQLQHLSNR 72 E+K+++ YWLN G + D P K + IEG + ++ +I L L+ Sbjct: 3759 EVKRQEDYWLNVFQGEVPVLNLPADEKRPQKRS--IEG-DIVQFEIDGETSAMLNKLAKE 3815 Query: 73 SDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHYVPI-IDTFTT---- 127 + ++Y +LL L+ K+T I V SP+ +S H + + I+T Sbjct: 3816 NGATMYMLLLAGYTTLLAKYTGQEDIVVGSPIAGRHHSD---LKHVIGLFINTLAMRNHP 3872 Query: 128 --GMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHNDA 185 M F + L +V+ET L AY++QDYPFD+++E + D + + +L N D Sbjct: 3873 KGDMPFADYLKEVKETALKAYENQDYPFDELVEKLDVKRDMSRHPLFDTMLVLQNFDGDE 3932 Query: 186 VIPDVGS-------------NIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQIL 232 D + ++ + GI Y+ K F R+ + ++A IL Sbjct: 3933 ADIDGLTFQPLQTEVNISKFDLTLTAAETNEGIQCVFNYSTKLFKRSTIERMAGHLINIL 3992 Query: 233 KGAAENVSIKLGSMXX-XXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQTPDHVAVK 291 K AA + + L + Q + +D T+++LFE+Q +TP+ AV Sbjct: 3993 KEAANDPHMPLSDVNMLSDEEMNALLDQNQGKQADYPQDQTVHQLFEQQADKTPEQTAVV 4052 Query: 292 FNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLPL 351 + ++ +TYR+LN +AN+LAR+LR++G A+Q V +++E S++M +L +LK+GAAY+P+ Sbjct: 4053 YADEKLTYRELNERANQLARLLRDKGADADQPVAIMIEPSLEMIISMLAVLKAGAAYVPI 4112 Query: 352 DIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDVLLENESDLDLILGRA 411 + + +R ++ D+ + + +E + G V D L++ + +L + Sbjct: 4113 EPEQLAKRTNEILSDSRAAILLVKGSVKENVAFAGEIVNVADG--LIDAKVASNLSASGS 4170 Query: 412 LDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGFLTS 471 D AY+IYTSG+TG+PKGV + H ++ N W E +D+ + + SY FD TS Sbjct: 4171 ADQNAYIIYTSGSTGKPKGVFVRHGNVVNYTTWFMKEAGLTENDKAMLVSSYAFDLGYTS 4230 Query: 472 FFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRN-----MKPEE 526 F+ ++SG+ + + + ++ I + IT+ P+L++ + + KP Sbjct: 4231 IFSALLSGSELHIARKECYTNAHRALKYIKENGITYIKLTPSLFNIFVNDPGFSAEKP-- 4288 Query: 527 AQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTEL--- 583 +LR+V L GE + + +P ++N YGPTE+++ + K + P+ + Sbjct: 4289 CATLRLVVLGGEMINTRDVETFYNQYPDHVVMNHYGPTETTIGSVFKV-IDPEHLDSFKE 4347 Query: 584 --TIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEA 641 IG PI NT Y++ +N++L G+ GELCI+GAG+ GY++ T++KF+ NPF Sbjct: 4348 CPVIGTPIHNTNAYVLDENMKLLPEGVYGELCIAGAGVTGGYVNRPDETKEKFIENPFAP 4407 Query: 642 NERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWE 701 + +MYRTGDLAR + G IE+ GR DTQVK+RGYRIE EI+NRLL ++ I EA +A E Sbjct: 4408 HTKMYRTGDLARRLSDGNIELAGRIDTQVKVRGYRIEPEEIKNRLLAHDDIKEAFIAARE 4467 Query: 702 DQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALR 761 D ++CAY D L ++R L LPEYM+P+ F Q+E+ P++ GK+D AL Sbjct: 4468 DHKGAKQLCAYFTADAELPFEDIRTYLMHELPEYMIPSSFVQIEKMPLSANGKIDTAALP 4527 Query: 762 NNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLH 821 Q KE ++ P NE E +LV+IW+ VL +DK+ I +FF GG S+KA ++SRL Sbjct: 4528 EPQPGKE--TEYEPPRNETEEKLVQIWEEVLGIDKIGITHHFFAAGGDSIKALQMISRLS 4585 Query: 822 KEFQVEIELDEIFEKQTICNLAALIK--SKRPGTYSSI-----LPTEKRDYYPMSSAQKR 874 +E + +E+ ++F I +L+ +K S + +Y ++ L +++Y+ ++ + Sbjct: 4586 RE-GLSLEMKDLFANPQIKSLSRYVKAESDKSASYETVEGEVLLTPIQQEYFSLNKTDR- 4643 Query: 875 MYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSF-----HMIHHE 929 YN ++ + D V+ V +++I H+ LRT F +I + Sbjct: 4644 -----------NHYNHAVMLYRKNGFDESIVKRVFKEIIKHHDALRTVFTEEDGKIIQYN 4692 Query: 930 --PVQVVHDTIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKIASRHYLFMF 987 P + + D + + ++ + A Q D++T PL ++ + K + +L + Sbjct: 4693 RGPDKQLFDLFVYDVSSENDQPQKVYQLATELQQSIDIETGPLVKLAVFKTNNGDHLLII 4752 Query: 988 DMHHIISDGISIGLFIKELALLY-----GNAVLPEPEI-QFKDFSVWEKESAENGDFKQQ 1041 +HH++ DGIS + ++LA+ Y G V P+ ++ ++ E A++ + Sbjct: 4753 -IHHLVVDGISWRILFEDLAIGYSQLANGEKVEFYPKTASYQAYARHIAEYAKSVKLLSE 4811 Query: 1042 EEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKL 1087 +++WLK V L++ + K + L+KE T++L Sbjct: 4812 KQYWLKAIAEGVEFLDM--NENAGAFKVEDSRTFSTELEKEETKRL 4855 Score = 466 bits (1198), Expect = e-129, Method: Compositional matrix adjust. Identities = 330/1120 (29%), Positives = 560/1120 (50%), Gaps = 81/1120 (7%) Query: 16 EMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQHLSNRSD 74 EMK++K+YWLN G + TD P +EG + + I L ++L+ ++ + Sbjct: 1223 EMKRQKEYWLNIFKGEIPVLNMPTDYPRPQMHSVEG-DRIGFAIDGELTKKLKRIAKDNG 1281 Query: 75 DSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHYVPIIDTFTTGM----- 129 ++Y +LL A L+ ++ + + +P+ ++ +I F + Sbjct: 1282 ATMYMLLLAAYTVLLRTYSGQEDVIIGTPI------QGRKHHELKHVIGMFVNTLAMRNH 1335 Query: 130 -----TFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN- 183 TF E L V+ET L AY++QDY FD ++E + D + + + +L N+ Sbjct: 1336 PKGDKTFAEYLQDVKETALKAYENQDYQFDDLVEQLDLERDMSRNPLFDTMFVLQNLEKA 1395 Query: 184 DAVIPDV------------GSNIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQI 231 DA I + ++ D+ I +L Y K F R V ++A + ++ Sbjct: 1396 DAEIEGLTFEPFESDIHISKFDLTLSAIEKDSKIEFDLEYCTKLFKRETVERMAAHFVRV 1455 Query: 232 LKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNM-EDMTLYELFEKQVRQTPDHVAV 290 L+ ++ +L + T + D T+ +LF ++ +PD AV Sbjct: 1456 LEDISKRTDKRLDQIEAMSEDEKNTLLYRFNDTKTDAPTDKTICQLFAERAETSPDKTAV 1515 Query: 291 KFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLP 350 F +Q++TYR L+ ++N+LAR LR +GV + VG++V+RS +M G+LGILK+G AYLP Sbjct: 1516 VFEDQTLTYRQLHERSNQLARFLREKGVQPDTAVGIMVDRSPEMIIGLLGILKAGGAYLP 1575 Query: 351 LDIKSPEERLQFLIEDAGIEVAVSNKQTEEK---LKRDGLTVIRLDDDVLLENESDLDLI 407 LD PE+R+++++ D+ + +S + +K +K + I + D + ++ Sbjct: 1576 LDPAYPEDRIKYILGDSQTKFLLSEEALIKKRAFIKEADMINIDIHDKQIAAQDAAQLEP 1635 Query: 408 LGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDG 467 + R+ D AY+IYTSG+TG+PKGV+IE + +SN + + R++Q S FD Sbjct: 1636 VSRSGD-LAYIIYTSGSTGKPKGVLIEQKGLSNLVSAVVKLMHLNTGSRVIQFASLSFDA 1694 Query: 468 FLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPEEA 527 F + +G+ +V + E + + + ITH PT+ L Sbjct: 1695 SAFEIFPALAAGSALVLGRQEEMMPGQPLTSFLRQYNITHATLPPTVLDVL----NESGL 1750 Query: 528 QSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELTIGK 587 ++L+++ AG + L +K+ +N YGPTE++V AT + IG Sbjct: 1751 ENLKVIVSAGSACSEEL---AKRWSGNRLFINAYGPTETTVCATA--GIYEGSGRPHIGS 1805 Query: 588 PIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEANERMYR 647 PI NT VY++ N + G+VGELC+ G LARGYL+ LT +KF+S+PF + ER+YR Sbjct: 1806 PIANTNVYVLDQNQKPVPTGVVGELCVGGMSLARGYLNRPELTAEKFISHPFASGERLYR 1865 Query: 648 TGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNS 707 TGDLARW G +E +GR D QVK+RGYRIELGEIEN+LL+ + I EA V +D + + Sbjct: 1866 TGDLARWLPDGHLEFLGRIDHQVKIRGYRIELGEIENQLLKLDKIDEAAVIARKDDDHSD 1925 Query: 708 RICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLK 767 +CAYIV ++ E+ E L K LP YM+P +F +L++ P+T K+DR AL Sbjct: 1926 YLCAYIVSKEDWTSTEISEWLEKELPHYMIPAYFVRLDKLPLTSNDKVDRKALPAPDRHV 1985 Query: 768 ELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVE 827 GA ++ P N+ E++LV+IW++VL + I +FF GG S+KA ++SRL + ++ Sbjct: 1986 ATGAVYEAPRNDTEAKLVDIWRDVLGAGDIGISHHFFAAGGDSIKALQIVSRLSR-LGLK 2044 Query: 828 IELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYALYHLEGESTS 887 +E+ ++F I +LA +K + ++ + T + P+ QK +A + + E Sbjct: 2045 LEMKDLFANPRIKDLAKYVKKQSQRKNANTIVTGHAELTPI---QKWYFA--NNKEELDH 2099 Query: 888 YNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYTEE 947 +N V+ +G D V+ +++ +H+ LR MI+ E D I ++ + E+ Sbjct: 2100 FNQSFVLFRKGGFDESCVKKAFNKIMEQHDALR----MIYEEKGG---DFIQYNRSFRED 2152 Query: 948 KID----DIRLEADRFIQPFDLDTS----------PLFRVKIIKIASRHYLFMFDMHHII 993 D D+R + + ++L TS L + I + +L + +HH++ Sbjct: 2153 LFDLDVYDVRGLDRQAEKVYELATSIQKLSSIRKGKLVHLGIFRADEGDHLLIV-IHHLV 2211 Query: 994 SDGISIGLFIKELALLYGNAVLPEP-EIQFKDFSVWE-----KESAENGDFKQQEEFWLK 1047 DG+S + ++ LY A+ + EI +K S E K A + ++ E+W Sbjct: 2212 VDGVSWRILFEDFETLYSQALKGQTLEIGYKTDSYQEFARRLKAYAHSRTLSKEAEYWRN 2271 Query: 1048 MFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKL 1087 + K V + K V+++ + + L KE T L Sbjct: 2272 IAKARVRFIPPKNVLKEDVYEN--STTLSIKLGKEATADL 2309 Score = 410 bits (1053), Expect = e-112, Method: Compositional matrix adjust. Identities = 263/865 (30%), Positives = 451/865 (52%), Gaps = 43/865 (4%) Query: 12 LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRLDIPDGLFQQLQHLSN 71 L + + K YW N + G S I S ++ ++ P+ L ++ L++ Sbjct: 5269 LQQQDKEAAKAYWRNYLSGFTEKSPISVLAGSSGHAKYKRKEAVIEFPEQLTGRITELAS 5328 Query: 72 RSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHYVPIIDTFTT---- 127 R++ + + +L L+ ++ ++ + + + + + I+T T Sbjct: 5329 RNNVTFHTVLQCIWGMLLARYNQTDDVVFGTVISGRDAQVTGIEKMVGLFINTVPTRIRL 5388 Query: 128 --GMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHNDA 185 +F+E + V+E L + D + +VQ++S+ + H+L + N D Sbjct: 5389 DKSQSFKELIKSVQEQALEGRTYHDMN----LSEVQSLSELKRELLDHIL-IFENYAVDQ 5443 Query: 186 VIPDVGSNIVFGFTRDD------------------AGISLNLIYNLKYFTRNFVMQLAKQ 227 + GF ++ + + L Y+ + + + + Sbjct: 5444 SAFETSGKRGAGFVFEEIHAEEQTNYGFNIVAVPGERLVIKLTYDGNIYHDHIIAGIKGH 5503 Query: 228 YFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQTPDH 287 Q+++ ++ L + T + T++ LFE+Q +TP+ Sbjct: 5504 LQQVMEQVVQHEDQSLNDITVLSEAERNRLLYEWNDTKAEYPNQTIHRLFEEQAEKTPEL 5563 Query: 288 VAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAA 347 AV N +TYR+LN K+N+LAR LR++GV A+ IV ++ ERS +M GI+GILK+G A Sbjct: 5564 AAVVSGNDKLTYRELNEKSNQLARYLRDKGVKADTIVAIMAERSPEMVVGIMGILKAGGA 5623 Query: 348 YLPLDIKSPEERLQFLIEDAGIEVAVSN-KQTEEKLKRDGLTVIRLDDDVLLENESDLDL 406 YLP+D PEER+++++ED+G + +++ KQ L ++ + L D +L+ Sbjct: 5624 YLPIDPDYPEERIKYMLEDSGAAIILADHKQDLGTLHQEA---VELTGDFSSYPADNLEP 5680 Query: 407 ILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYI-F 465 G A D AY+IYTSG+TG+PKGV+I R + N I W Y L+S I F Sbjct: 5681 A-GNA-DSLAYIIYTSGSTGKPKGVMIRQRGLVNYITWADRVY-VQGEQLDFALYSSIAF 5737 Query: 466 DGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPE 525 D +TS FTP++SG V+ +E +PL I+ + + + + + +L+++M Sbjct: 5738 DLTVTSIFTPLISGNRVIVYRHSEDGEPL--IRKVFRDQKAGIVKLTPSHLSLVKDMDAS 5795 Query: 526 EAQSLRIVTLAGEKVTPNLLIA-SKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTELT 584 S++ + + GE + L +++ H +EI NEYGPTE+ V + + D +++ Sbjct: 5796 -GSSIKRLIVGGEDLKTELAKEITERFHHNIEIYNEYGPTETVVGCMIYQYDAGWDRQVS 5854 Query: 585 --IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEAN 642 IGKP N ++YI+ + E++ G+ GEL ISG G+A+GYL+ LT +KF+ NPF Sbjct: 5855 VPIGKPASNVQLYILDERQEVQPVGIAGELYISGDGVAKGYLNKPELTSEKFLPNPFLPG 5914 Query: 643 ERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWED 702 ERMYRTGDLA+ G IE +GR D QVK+RGYRIELGEIE++LL ++ I EA VA D Sbjct: 5915 ERMYRTGDLAKMRPDGHIEYLGRIDHQVKIRGYRIELGEIEHQLLRHSDIKEAAVAAKTD 5974 Query: 703 QNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRN 762 QN++ +CAY+V +R ++ +++ L+K LPEYM+P++ +L++ P+TP GK+D AL Sbjct: 5975 QNNDQVLCAYVVSERDITQKDIKTFLAKELPEYMVPSYLLKLDELPLTPNGKVDLKALPE 6034 Query: 763 NQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHK 822 ++ P +E+E ++ IW+++L ++++ I+ N F +G +SL +SRL+ Sbjct: 6035 PDRSAGALLEYEPPRHELEEKMAAIWEDILNIEQIGINANIFDIGANSLNVMSFVSRLYA 6094 Query: 823 EFQVEIELDEIFEKQTICNLAALIK 847 E + +IF K TI L+ +K Sbjct: 6095 ELGFRVPFKDIFSKPTIKELSDFLK 6119 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.320 0.137 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 3,441,931,018 Number of extensions: 148701951 Number of successful extensions: 395913 Number of sequences better than 1.0e-05: 3622 Number of HSP's gapped: 372687 Number of HSP's successfully gapped: 7181 Length of query: 2351 Length of database: 757,237,578 Length adjustment: 142 Effective length of query: 2209 Effective length of database: 371,693,520 Effective search space: 821070985680 Effective search space used: 821070985680 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 134 (56.2 bits)