BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0560.0025.p (4011 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value sp|O68008|BACC_BACLI Bacitracin synthetase 3 (BA3) [Includes: AT... 1562 0.0 sp|O68006|BACA_BACLI Bacitracin synthetase 1 (BA1) [Includes: AT... 1461 0.0 ref|ZP_00177151.1| hypothetical protein Cwat285401 [Crocosphaera... 1336 0.0 sp|O30408|TYCB_BREPA Tyrocidine synthetase II [Includes: ATP-dep... 1305 0.0 dbj|BAB69699.1| iturin A synthetase B [Bacillus subtilis] 1302 0.0 >sp|O68008|BACC_BACLI Bacitracin synthetase 3 (BA3) [Includes: ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); ATP-dependent D-phenylalanine adenylase (D-PheA) (D-phenylalanine activase); ATP-dependent histidine adenylase (HisA) (Histidine activase); ATP-dependent D-aspartate adenylase (D-AspA) (D-aspartate activase); ATP-dependent asparagine adenylase (AsnA) (Asparagine activase); Aspartate racemase ; Phenylalanine racemase [ATP hydrolyzing] ] pir||T31679 bacitracin synthetase 3 - Bacillus licheniformis gb|AAC06348.1| bacitracin synthetase 3; BacC [Bacillus licheniformis] Length = 6359 Score = 1562 bits (4044), Expect = 0.0, Method: Compositional matrix adjust. Identities = 854/2247 (38%), Positives = 1312/2247 (58%), Gaps = 78/2247 (3%) Query: 1800 VILDKDMHPSPVGVPGEVYLA-------RLTEPSLLAEQ-------PST---STGIMAMY 1842 +I+D+ P+GVPGE+ +A L L AE+ P TG +A + Sbjct: 781 LIMDEAGKLLPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERLYKTGDLAKW 840 Query: 1843 TADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAY 1902 D I+ IG + G I L I+ +L +H I VTV+ + I AY Sbjct: 841 LPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDE--ESRPYICAY 898 Query: 1903 ITP-RGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKAL 1961 IT R S+ E+K FL ++P IP+ F+ +D++PL G ++ + LP D Sbjct: 899 ITANREISLD---ELKGFLGEKLPEYMIPAYFVKMDKLPLTKNGKVDRKALPEPDRTAGA 955 Query: 1962 REEIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDIS 2021 E P NETEE+LA IWR++L +E ND FFE+GG+SLKA+ +A I+KE +I Sbjct: 956 ENEYEAPRNETEEKLAAIWRDILKVEKSGINDHFFEMGGHSLKAAAMAARIRKELKAEIP 1015 Query: 2022 LRMLFEHPTVKGLAKAINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGGAGTAYN 2081 L +F+ PT+KGL + I S I + +K++Y SS+QKRL+ ++Q+ G+G +YN Sbjct: 1016 LGQIFKTPTIKGLGEYIRSTKDSVYSSIQKVEEKEYYRLSSAQKRLYILDQIEGSGLSYN 1075 Query: 2082 ITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSISYSIAED 2141 I + V+G+ D R E A + +++RHE LRTSF + EPVQ I ++ FSI S + Sbjct: 1076 IPFTMKVKGRFDIRRFENALKTIIQRHEALRTSFLMADGEPVQKIEKEVDFSIKCSKIQS 1135 Query: 2142 EDEPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGISANILCNDLISL 2201 E++K+F+ PF L +APLFR +V D EHI++ DMHHII+DG S +L ++ L Sbjct: 1136 LSIQEIIKQFVRPFDLKKAPLFRTEVVKVDDEEHIILFDMHHIISDGASMGVLTKEICDL 1195 Query: 2202 YSGENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQS 2261 Y G+ L L +QYKDY+ + + +++Q EYW + +IP L +P D+PRP + S Sbjct: 1196 YGGKELKPLSLQYKDYSEWQRDFYQKDEMKRQKEYWLNIFKGEIPVLNMPTDYPRPQMHS 1255 Query: 2262 FDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRF 2321 +G +D +LT+ LK ++ T+Y LLLA+Y +LL YS QED++IG+P+ GR Sbjct: 1256 VEGDRIGFAIDGELTKKLKRIAKDNGATMYMLLLAAYTVLLRTYSGQEDVIIGTPIQGRK 1315 Query: 2322 NYSTNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIER 2381 ++ +++GMFVNTLAMRN P KTF E+L +VKE L+A+ENQDY F++L+ +L +ER Sbjct: 1316 HHELKHVIGMFVNTLAMRNHPKGDKTFAEYLQDVKETALKAYENQDYQFDDLVEQLDLER 1375 Query: 2382 DISRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKFDLILEVIENTENLTLNF 2441 D+SRNP+FD MFVLQ+L+ A D ++ + +E ++KFDL L IE + + Sbjct: 1376 DMSRNPLFDTMFVLQNLEKA--DAEIEGLTFEPFESDIHISKFDLTLSAIEKDSKIEFDL 1433 Query: 2442 EYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYP 2501 EYC KLF+ T+ RM+ F+R+L + + + L I+ + ++E + L+Y FNDT T P Sbjct: 1434 EYCTKLFKRETVERMAAHFVRVLEDISKRTDKRLDQIEAMSEDEKNTLLYRFNDTKTDAP 1493 Query: 2502 GGKTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILM 2561 KT+ QLF E+A +P A+V + +++TY + ++NQ+AR LR KGV+PDT VGI++ Sbjct: 1494 TDKTICQLFAERAETSPDKTAVVFEDQTLTYRQLHERSNQLARFLREKGVQPDTAVGIMV 1553 Query: 2562 EHSFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEF 2621 + S E+II + ++KAGGAY+P+DP YP +RI +I+ DS + +L+ + L +K F E Sbjct: 1554 DRSPEMIIGLLGILKAGGAYLPLDPAYPEDRIKYILGDSQTKFLLSEEALIKKRAFIKEA 1613 Query: 2622 ----IDAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGD 2677 ID + D + V+ DLAYIIYTSGSTG PKGV+ +GL+N V Sbjct: 1614 DMINIDIHDKQIAAQDAAQLEPVSRSGDLAYIIYTSGSTGKPKGVLIEQKGLSNLVSAVV 1673 Query: 2678 KTYVHGEAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSGVSYESL----LEAVVIDNQ 2733 K ++S++FD S I+ L +G+ + + G E + L + + Sbjct: 1674 KLMHLNTGSRVIQFASLSFDASAFEIFPALAAGSALVL--GRQEEMMPGQPLTSFLRQYN 1731 Query: 2734 VDFIMLTPSHLKILGEYDLSRLKIRKFIIGGEAFDPFYAKKFF-SRLAEDVEVYNVYGPT 2792 + L P+ L +L E L LK+ + G A AK++ +RL N YGPT Sbjct: 1732 ITHATLPPTVLDVLNESGLENLKV--IVSAGSACSEELAKRWSGNRL-----FINAYGPT 1784 Query: 2793 ETTVACTFYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRG 2852 ETTV T Y + IG PI N +YV+DQN K G+ GELC+ G ++RG Sbjct: 1785 ETTVCATAGIY----EGSGRPHIGSPIANTNVYVLDQNQKPVPTGVVGELCVGGMSLARG 1840 Query: 2853 YLNREELTREKFVPDPFQTSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEI 2912 YLNR ELT EKF+ PF + +YRTGDL R L DG++EFLGR+D QVKIRG+RIELGEI Sbjct: 1841 YLNRPELTAEKFISHPFASGERLYRTGDLARWLPDGHLEFLGRIDHQVKIRGYRIELGEI 1900 Query: 2913 ENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFV 2972 ENQL+K +++AAVI S YLCAY + P +M+P++FV Sbjct: 1901 ENQLLKLDKIDEAAVIARKDDDHSDYLCAYIVSKEDWTSTEISEWLEKELPHYMIPAYFV 1960 Query: 2973 QMKSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNS 3032 ++ +PLT++ KVDRK LP Y AP+N E KL +W +VLG +G S+ Sbjct: 1961 RLDKLPLTSNDKVDRKALPAPDRHVATGAVYEAPRNDTEAKLVDIWRDVLGAGDIGISHH 2020 Query: 3033 FIKLGGDSIKAIQIVSRLKKYGLSLEVKELFLHQNIKGISPFVKQNIKRHNQGTI-EGPV 3091 F GGDSIKA+QIVSRL + GL LE+K+LF + IK ++ +VK+ +R N TI G Sbjct: 2021 FFAAGGDSIKALQIVSRLSRLGLKLEMKDLFANPRIKDLAKYVKKQSQRKNANTIVTGHA 2080 Query: 3092 KLTAIQKWFFEQNFAEMHHWNQS-ILLHNERFDVQFIRQAFQRITEHHDALRMVYRHTGQ 3150 +LT IQKW+F N E+ H+NQS +L FD +++AF +I E HDALRM+Y G Sbjct: 2081 ELTPIQKWYFANNKEELDHFNQSFVLFRKGGFDESCVKKAFNKIMEQHDALRMIYEEKGG 2140 Query: 3151 AGVEQSNRGLAGELFSLEVTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGLYQTTN 3210 + Q NR +LF L+V D+ G D + ++ +IQK + KG L+ LG+++ Sbjct: 2141 DFI-QYNRSFREDLFDLDVYDVRGLDRQAEKVYELATSIQKLSSIRKGKLVHLGIFRADE 2199 Query: 3211 GDYLAIVIHHLVVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALEVYANS 3270 GD+L IVIHHLVVDGVSWRI+ +DF + Y G+ + K+DSYQ++A L+ YA+S Sbjct: 2200 GDHLLIVIHHLVVDGVSWRILFEDFETLYSQALKGQTLEIGYKTDSYQEFARRLKAYAHS 2259 Query: 3271 PKLLQELAYWTDVNRIAVPALPKDSEAGNGKIKDRYQTKTVLS----EKETTNLLRHAGD 3326 L +E YW ++ + V +P N +D Y+ T LS ++ T +LLR+ Sbjct: 2260 RTLSKEAEYWRNIAKARVRFIP----PKNVLKEDVYENSTTLSIKLGKEATADLLRNTNR 2315 Query: 3327 AYQTETXXXXXXXXXXXIKGWANVDRVRINMEGHGREALIQDLDITRTVGWFTSTYPLVL 3386 AY TE + +++++ MEGHGRE +++ +DITRT+GWFT+ YP++L Sbjct: 2316 AYNTEINDILLTALLTGARDITGENKLKVMMEGHGREDILEGVDITRTIGWFTTMYPVLL 2375 Query: 3387 ELANSHELPLHIMTTKETIRQTPNKGMGYQVLKYLTSPELRAAVDFN--VMPEISFNYLG 3444 + L I KET+R+ PNKG+GY +LKY+ DF ISFNYLG Sbjct: 2376 DAGEEKALSQQIKMVKETLRKIPNKGIGYGLLKYMAEDP-----DFTNEEKARISFNYLG 2430 Query: 3445 QFGNEASYGTFEICNTFMESTESPESHRPYAIDINAMIVGNRVEIRVDYNPGQFNEATMS 3504 + + G F + + + R ++I+INA+++ + + I +N ++ + T+S Sbjct: 2431 DIDADMNRGEFSGSSFSEGESIGGKIARSHSIEINAIVMNHELVIHTTFNQMEYEKDTIS 2490 Query: 3505 RFAELLLNSLKLIISHCTREERIQRSPSDLTYKKLTFEELDDLNRLYPGGITDVYTMTPM 3564 R L L+ II HCT++ +R+PSD ++ EL+++ Y I +Y + M Sbjct: 2491 RLNHQLKERLEQIIKHCTQQTESERTPSDYGDTNISLAELEEIKGKYRSAIEKIYPLANM 2550 Query: 3565 QESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRFVYKKLHRP 3624 Q+ MLFHA+++ SDAY +Q ++D++G + +L SF I+ +++ILR + Y+ + P Sbjct: 2551 QKGMLFHAIEDHTSDAYFQQTVMDIEGYVDPAILEASFNDIMKRHEILRASYEYEIVEEP 2610 Query: 3625 LQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGPLMRAILLKTGDSV 3684 QI++ + + +I + ++ +ERL DR+K FDL + LMRA LLKT + Sbjct: 2611 RQIIIENRSIDFTYFNIAKSSAQQQEMFIERLLNEDRKKGFDLSKDVLMRAYLLKTAERS 2670 Query: 3685 YQMLWSFHHILMDGWCIGIVLKDMLEHYK-QLNAGSRPSLETHQYRLYLDWLASKNKEEA 3743 Y+++WS HHIL+DGWC+GI+++++ Y+ ++N + P ET Y Y+ WL +++EEA Sbjct: 2671 YRLVWSHHHILLDGWCLGIIMRELFVIYENRMNGKASPLKETKPYSDYIKWLERQDQEEA 2730 Query: 3744 KVYWMQYLEDYKYKELL-----RKEGTSKEFRLAVLDIKLEEKVRTAVTHVASSSGITIN 3798 + YW +YL+ Y+ + L RK+ + + R V I L +++ + +A+ + +T++ Sbjct: 2731 RQYWREYLKGYEEQAQLPTLTKRKKSSRYDRREKV--IHLSKQLTKQLKELAAKNSVTLH 2788 Query: 3799 SFFQAVWGILLSKYDNAEDVVFGAVISGRSPEIEGIERMVGLFINTIPVRVRLSGKT-FH 3857 + Q +WG++L++Y +DVVFG V+SGR ++GIE M+GLFINTIP R+R + + F+ Sbjct: 2789 TVIQTIWGLMLTRYTKIDDVVFGTVVSGREANVDGIEDMIGLFINTIPTRIRFNEQARFN 2848 Query: 3858 ELAGEIQSSFISSEQYGYVPLSDIQAWS--HRDLINHVMVFENYPLDREIRDTDGQQMEY 3915 + ++Q I S +Y Y+ L+++QA S +DLI+H++VFENY D + D + QM+ Sbjct: 2849 DCLQKVQEDAIQSNRYNYMNLAEVQALSSLKKDLIDHILVFENYEADEQ--DFEESQMKT 2906 Query: 3916 GFQIAGCEILEHTNYDFSIIIEPGEDFIIRIVYNALAYDKETISILESYLLAIIGQVTAC 3975 GF++ E + FS+ + PGE+ + + Y+ YD++ I+ +E ++ + QVTA Sbjct: 2907 GFKVNEISAAEQSITAFSMSVTPGEELTLVLTYDGNVYDRDIINNIEGHIKRVAEQVTAN 2966 Query: 3976 PQIEAGDVEVLSQEEKLKLMNVFNKPN 4002 + ++++L++EE+ L+ FN+ N Sbjct: 2967 ENRKIAEIDMLAEEERKTLLYEFNRTN 2993 Score = 1495 bits (3870), Expect = 0.0, Method: Compositional matrix adjust. Identities = 843/2239 (37%), Positives = 1272/2239 (56%), Gaps = 59/2239 (2%) Query: 1801 ILDKDMHPSPVGVPGEVYL-----AR--LTEPSLLAEQ-------PSTS---TGIMAMYT 1843 IL+ + P+G PGE+ L AR L P L E+ P S TG +A + Sbjct: 3319 ILNHNQQLLPLGTPGELCLSGEGLARGYLNRPDLTLEKFVPNPFAPGESMYRTGDLARFL 3378 Query: 1844 ADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKIL-AY 1902 D +I+ +G + G I L I+ QL+ I AAV + Q K L AY Sbjct: 3379 PDGQIEYLGRIDHQVKIRGFRIELGEIENQLLKIEGIDAAAVMARED---QAGGKYLCAY 3435 Query: 1903 ITPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALR 1962 I + V +++K LL +P +PS F+ LD++PL + G I+ + LP + + Sbjct: 3436 IVADKAA--GVADVRKCLLKELPDYMVPSYFVKLDQLPLTANGKIDRKALP--EPSSTIS 3491 Query: 1963 EEIM-LPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDIS 2021 E P N TEE+L IW +VL +E + + +FFELGG+SLKA+ L + KE ++ Sbjct: 3492 EATYEAPRNRTEEKLVSIWEDVLGIENIGISHNFFELGGHSLKAAALTAKLHKEMKIEVP 3551 Query: 2022 LRMLFEHPTVKGLAKAINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGGAGTAYN 2081 LR LFE PT+K + I +S IT +K++Y SS+Q+RL+ + Q+ G +YN Sbjct: 3552 LRQLFETPTIKDIGDFIESMKESPYASITQAEEKEYYALSSAQRRLYILNQIEPGGLSYN 3611 Query: 2082 ITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSISYSIAED 2141 + + + G D R E+AF++L++RHE LRT+F ++ EPVQ I ++ F + Y Sbjct: 3612 MPFAMKIAGDFDVDRFEDAFRQLIERHEALRTAFVMVDGEPVQKIEKEVDFKVKYGRLGQ 3671 Query: 2142 EDEPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGISANILCNDLISL 2201 + E +K FI PF+L +APL R ++ S EH++++DMHHII+DG+S I +L L Sbjct: 3672 DPLEEKIKAFIKPFALEKAPLLRAEVLKASGDEHVLMLDMHHIISDGVSMAIFTRELAEL 3731 Query: 2202 YSGENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQS 2261 Y G+ LP L +QYKD++ + +++Q +YW + ++P L LP D RP +S Sbjct: 3732 YEGKTLPPLTIQYKDFSEWQKLFYQKDEVKRQEDYWLNVFQGEVPVLNLPADEKRPQKRS 3791 Query: 2262 FDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRF 2321 +G +D + + L L+ T+Y LLLA Y LL+KY+ QEDIV+GSP+AGR Sbjct: 3792 IEGDIVQFEIDGETSAMLNKLAKENGATMYMLLLAGYTTLLAKYTGQEDIVVGSPIAGRH 3851 Query: 2322 NYSTNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIER 2381 + +++G+F+NTLAMRN P F ++L EVKE L+A+ENQDYPF+EL+ KL ++R Sbjct: 3852 HSDLKHVIGLFINTLAMRNHPKGDMPFADYLKEVKETALKAYENQDYPFDELVEKLDVKR 3911 Query: 2382 DISRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKFDLILEVIENTENLTLNF 2441 D+SR+P+FD M VLQ+ D D+ D + + + +++KFDL L E E + F Sbjct: 3912 DMSRHPLFDTMLVLQNFDGDEADI--DGLTFQPLQTEVNISKFDLTLTAAETNEGIQCVF 3969 Query: 2442 EYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYP 2501 Y KLF+ STI RM+ + IL + ++ LSD+++L EE + L+ YP Sbjct: 3970 NYSTKLFKRSTIERMAGHLINILKEAANDPHMPLSDVNMLSDEEMNALLDQNQGKQADYP 4029 Query: 2502 GGKTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILM 2561 +TV+QLFE+QA +TP A+V+ E +TY N + NQ+AR+LR KG D V I++ Sbjct: 4030 QDQTVHQLFEQQADKTPEQTAVVYADEKLTYRELNERANQLARLLRDKGADADQPVAIMI 4089 Query: 2562 EHSFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEF 2621 E S E+IISM AV+KAG AYVPI+P ++R N I+ DS I+L + E F GE Sbjct: 4090 EPSLEMIISMLAVLKAGAAYVPIEPEQLAKRTNEILSDSRAAILLVKGSVKENVAFAGEI 4149 Query: 2622 IDAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYV 2681 ++ A SN + S D AYIIYTSGSTG PKGV RH + NY W K Sbjct: 4150 VNVADGLIDAKVASNLSASGSADQNAYIIYTSGSTGKPKGVFVRHGNVVNYTTWFMKEAG 4209 Query: 2682 HGEAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSGVSYESLLEAV--VIDNQVDFIML 2739 E L SS AFDL T I+ L+SG+++ I Y + A+ + +N + +I L Sbjct: 4210 LTENDKAMLVSSYAFDLGYTSIFSALLSGSELHIARKECYTNAHRALKYIKENGITYIKL 4269 Query: 2740 TPSHLKI-LGEYDLSRLK----IRKFIIGGEAFDPFYAKKFFSRLAEDVEVYNVYGPTET 2794 TPS I + + S K +R ++GGE + + F+++ + V V N YGPTET Sbjct: 4270 TPSLFNIFVNDPGFSAEKPCATLRLVVLGGEMINTRDVETFYNQYPDHV-VMNHYGPTET 4328 Query: 2795 TVACTFYRYYPDK-DLRNPVP-IGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRG 2852 T+ F P+ D P IG PI N YV+D+N KL G+ GELCIAG GV+ G Sbjct: 4329 TIGSVFKVIDPEHLDSFKECPVIGTPIHNTNAYVLDENMKLLPEGVYGELCIAGAGVTGG 4388 Query: 2853 YLNREELTREKFVPDPFQTSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEI 2912 Y+NR + T+EKF+ +PF MYRTGDL R L DGN+E GR+D QVK+RG+RIE EI Sbjct: 4389 YVNRPDETKEKFIENPFAPHTKMYRTGDLARRLSDGNIELAGRIDTQVKVRGYRIEPEEI 4448 Query: 2913 ENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFV 2972 +N+L+ + +A + ++ LCAY+TAD + P +M+PS FV Sbjct: 4449 KNRLLAHDDIKEAFIAAREDHKGAKQLCAYFTADAELPFEDIRTYLMHELPEYMIPSSFV 4508 Query: 2973 QMKSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNS 3032 Q++ +PL+A+GK+D LP+ + E Y P+N EEKL +WEEVLGI+K+G ++ Sbjct: 4509 QIEKMPLSANGKIDTAALPEPQPGKETE--YEPPRNETEEKLVQIWEEVLGIDKIGITHH 4566 Query: 3033 FIKLGGDSIKAIQIVSRLKKYGLSLEVKELFLHQNIKGISPFVK-QNIKRHNQGTIEGPV 3091 F GGDSIKA+Q++SRL + GLSLE+K+LF + IK +S +VK ++ K + T+EG V Sbjct: 4567 FFAAGGDSIKALQMISRLSREGLSLEMKDLFANPQIKSLSRYVKAESDKSASYETVEGEV 4626 Query: 3092 KLTAIQKWFFEQNFAEMHHWNQSILLHNER-FDVQFIRQAFQRITEHHDALRMVYRHTGQ 3150 LT IQ+ +F N + +H+N +++L+ + FD +++ F+ I +HHDALR V+ T + Sbjct: 4627 LLTPIQQEYFSLNKTDRNHYNHAVMLYRKNGFDESIVKRVFKEIIKHHDALRTVF--TEE 4684 Query: 3151 AG-VEQSNRGLAGELFSLEVTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGLYQTT 3209 G + Q NRG +LF L V D++ +D ++ +Q+ ID+E GPL+KL +++T Sbjct: 4685 DGKIIQYNRGPDKQLFDLFVYDVSSENDQPQKVYQLATELQQSIDIETGPLVKLAVFKTN 4744 Query: 3210 NGDYLAIVIHHLVVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALEVYAN 3269 NGD+L I+IHHLVVDG+SWRI+ +D A Y L NGE+ K+ SYQ +A + YA Sbjct: 4745 NGDHLLIIIHHLVVDGISWRILFEDLAIGYSQLANGEKVEFYPKTASYQAYARHIAEYAK 4804 Query: 3270 SPKLLQELAYWTDVNRIAVPALPKDSEAGNGKIKDRYQTKTVLSEKETTNLLRHAGDAYQ 3329 S KLL E YW V L + AG K++D T L ++ET LLR AY Sbjct: 4805 SVKLLSEKQYWLKAIAEGVEFLDMNENAGAFKVEDSRTFSTELEKEETKRLLRETNRAYH 4864 Query: 3330 TETXXXXXXXXXXXIKGWANVDRVRINMEGHGREALIQDLDITRTVGWFTSTYPLVLELA 3389 TE + +++RI +EGHGRE + +DI+RTVGWFTS YP+ ++L Sbjct: 4865 TEINDILITALLVAARDMNGQNQLRITLEGHGREQVADGIDISRTVGWFTSKYPVFIDLG 4924 Query: 3390 NSHELPLHIMTTKETIRQTPNKGMGYQVLKYLTSPELRAAVDFNVMPEISFNYLGQFGNE 3449 ++ I KE +R PNKG+GY +LKYLT + + I FNYLGQ + Sbjct: 4925 QETDMSRTIKMVKEHLRNVPNKGIGYGILKYLTRD---SEIAKGAASPILFNYLGQLDED 4981 Query: 3450 ASYGTFEICNTFMESTESPESHRPYAIDINAMIVGNRVEIRVDYNPGQFNEATMSRFAEL 3509 + G F + R + ++INA++ ++ I+ YN ++E + FA+ Sbjct: 4982 INSGEFSSSHLSPGEAAGKGITREHPLEINAVVFRGKLAIQTTYNTRAYSEDVVRAFAQN 5041 Query: 3510 LLNSLKLIISHCTREERIQRSPSDLTYKKLTFEELDDLNRLYPG-GITDVYTMTPMQESM 3568 +LK +I HC E +++PSD K ++ ++L+++ Y G I +Y + MQ M Sbjct: 5042 YKEALKAVIRHCAEREETEKTPSDYGDKGISLDQLEEIKLKYKGMEIEKIYPLANMQRGM 5101 Query: 3569 LFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRFVYKKLHRPLQIV 3628 LFHAL++K S AY EQ +++KG I + L E+F I+ +++ILR Y+ P ++ Sbjct: 5102 LFHALEDKESQAYFEQMAINMKGLIDERLFAETFNDIMERHEILRASIEYEITDEPRNVI 5161 Query: 3629 LGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGPLMRAILLKTGDSVYQML 3688 + +L++ D+ +E+ ++ + DREK F L PL+RA L++T D Y + Sbjct: 5162 IKDRKINLDYHDLRKQSPAEREQVIQAYRKADREKGFRLNSEPLIRAALMRTEDDSYTFI 5221 Query: 3689 WSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSLETHQ-YRLYLDWLASKNKEEAKVYW 3747 W+ HHIL+DGW GI++ ++ Y A + LE + Y Y+ WL ++KE AK YW Sbjct: 5222 WTNHHILLDGWSRGIIMGELFHMYHMKEARQKHRLEEARPYSDYIGWLQQQDKEAAKAYW 5281 Query: 3748 MQYLEDYKYKE----LLRKEGTSKEFRLAVLDIKLEEKVRTAVTHVASSSGITINSFFQA 3803 YL + K L G +K R + I+ E++ +T +AS + +T ++ Q Sbjct: 5282 RNYLSGFTEKSPISVLAGSSGHAKYKRKEAV-IEFPEQLTGRITELASRNNVTFHTVLQC 5340 Query: 3804 VWGILLSKYDNAEDVVFGAVISGRSPEIEGIERMVGLFINTIPVRVRL-SGKTFHELAGE 3862 +WG+LL++Y+ +DVVFG VISGR ++ GIE+MVGLFINT+P R+RL ++F EL Sbjct: 5341 IWGMLLARYNQTDDVVFGTVISGRDAQVTGIEKMVGLFINTVPTRIRLDKSQSFKELIKS 5400 Query: 3863 IQSSFISSEQYGYVPLSDIQAWSH--RDLINHVMVFENYPLDREIRDTDGQQMEYGFQIA 3920 +Q + Y + LS++Q+ S R+L++H+++FENY +D+ +T G++ GF Sbjct: 5401 VQEQALEGRTYHDMNLSEVQSLSELKRELLDHILIFENYAVDQSAFETSGKRGA-GFVFE 5459 Query: 3921 GCEILEHTNYDFSIIIEPGEDFIIRIVYNALAYDKETISILESYLLAIIGQVTACPQIEA 3980 E TNY F+I+ PGE +I++ Y+ Y I+ ++ +L ++ QV Sbjct: 5460 EIHAEEQTNYGFNIVAVPGERLVIKLTYDGNIYHDHIIAGIKGHLQQVMEQVVQHEDQSL 5519 Query: 3981 GDVEVLSQEEKLKLMNVFN 3999 D+ VLS+ E+ +L+ +N Sbjct: 5520 NDITVLSEAERNRLLYEWN 5538 Score = 623 bits (1607), Expect = e-176, Method: Compositional matrix adjust. Identities = 373/1050 (35%), Positives = 567/1050 (54%), Gaps = 51/1050 (4%) Query: 2058 YPQSSSQKRLFAIEQMGGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFEL 2117 YP ++ Q+ + AY ++++G +D E F +++RHE LR S E Sbjct: 5092 YPLANMQRGMLFHALEDKESQAYFEQMAINMKGLIDERLFAETFNDIMERHEILRASIEY 5151 Query: 2118 -LHDEPVQVIHDDIPFSISY------SIAEDEDEPELVKRFILP--FSLNQAPLFRVHIV 2168 + DEP VI D ++ Y S AE E + ++ F LN PL R ++ Sbjct: 5152 EITDEPRNVIIKDRKINLDYHDLRKQSPAEREQVIQAYRKADREKGFRLNSEPLIRAALM 5211 Query: 2169 SRSDHEHIVIMDMHHIIADGISANILCNDLISLY---SGENLPGLEVQ--YKDYTALHNE 2223 D + I HHI+ DG S I+ +L +Y LE Y DY Sbjct: 5212 RTEDDSYTFIWTNHHILLDGWSRGIIMGELFHMYHMKEARQKHRLEEARPYSDYIG---- 5267 Query: 2224 MLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLS 2283 L + YW+ LS + + + + LT + L+ Sbjct: 5268 WLQQQDKEAAKAYWRNYLSGFTEKSPISVLAGSSGHAKYKRKEAVIEFPEQLTGRITELA 5327 Query: 2284 NRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNYST--NNMVGMFVNTLAMRNQ 2341 +R T +T+L + +LL++Y+ +D+V G+ ++GR T MVG+F+NT+ R + Sbjct: 5328 SRNNVTFHTVLQCIWGMLLARYNQTDDVVFGTVISGRDAQVTGIEKMVGLFINTVPTRIR 5387 Query: 2342 PAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLA 2401 K ++F+E + V+E LE D E+ S ++R++ D + + ++ + Sbjct: 5388 LDKSQSFKELIKSVQEQALEGRTYHDMNLSEVQSLSELKREL-----LDHILIFENYAVD 5442 Query: 2402 VPDVHLDDIRLNGYEFKNDVAK------FDLILEVIENTENLTLNFEYCAKLFQESTIIR 2455 R G+ F+ A+ F++ V E L + Y ++ + I Sbjct: 5443 QSAFETSGKRGAGFVFEEIHAEEQTNYGFNI---VAVPGERLVIKLTYDGNIYHDHIIAG 5499 Query: 2456 MSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAA 2515 + +++ VV++ + L+DI +L + E +RL+Y +NDT YP +T+++LFEEQA Sbjct: 5500 IKGHLQQVMEQVVQHEDQSLNDITVLSEAERNRLLYEWNDTKAEYPN-QTIHRLFEEQAE 5558 Query: 2516 RTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEHSFELIISMFAVM 2575 +TP A+V + +TY N K+NQ+AR LR KGVK DT V I+ E S E+++ + ++ Sbjct: 5559 KTPELAAVVSGNDKLTYRELNEKSNQLARYLRDKGVKADTIVAIMAERSPEMVVGIMGIL 5618 Query: 2576 KAGGAYVPIDPTYPSERINFIIKDSNLEIMLT-HKG-----LAEKCQFQGEFIDAASSKW 2629 KAGGAY+PIDP YP ERI ++++DS I+L HK E + G+F Sbjct: 5619 KAGGAYLPIDPDYPEERIKYMLEDSGAAIILADHKQDLGTLHQEAVELTGDF------SS 5672 Query: 2630 YCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYVHGEAVDFP 2689 Y D+ P + D LAYIIYTSGSTG PKGVM R +GL NY+ W D+ YV GE +DF Sbjct: 5673 YPADNLEPAG--NADSLAYIIYTSGSTGKPKGVMIRQRGLVNYITWADRVYVQGEQLDFA 5730 Query: 2690 LYSSIAFDLSVTLIYIPLISGNKVFIYS-GVSYESLLEAVVIDNQVDFIMLTPSHLKILG 2748 LYSSIAFDL+VT I+ PLISGN+V +Y E L+ V D + + LTPSHL ++ Sbjct: 5731 LYSSIAFDLTVTSIFTPLISGNRVIVYRHSEDGEPLIRKVFRDQKAGIVKLTPSHLSLVK 5790 Query: 2749 EYDLSRLKIRKFIIGGEAFDPFYAKKFFSRLAEDVEVYNVYGPTETTVACTFYRYYPDKD 2808 + D S I++ I+GGE AK+ R ++E+YN YGPTET V C Y+Y D Sbjct: 5791 DMDASGSSIKRLIVGGEDLKTELAKEITERFHHNIEIYNEYGPTETVVGCMIYQYDAGWD 5850 Query: 2809 LRNPVPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREELTREKFVPDP 2868 + VPIG P NVQLY++D+ ++Q +GI GEL I+GDGV++GYLN+ ELT EKF+P+P Sbjct: 5851 RQVSVPIGKPASNVQLYILDERQEVQPVGIAGELYISGDGVAKGYLNKPELTSEKFLPNP 5910 Query: 2869 FQTSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVI 2928 F MYRTGDL +M DG++E+LGR+D QVKIRG+RIELGEIE+QL++ + +AAV Sbjct: 5911 FLPGERMYRTGDLAKMRPDGHIEYLGRIDHQVKIRGYRIELGEIEHQLLRHSDIKEAAVA 5970 Query: 2929 ISTGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRK 2988 T + + LCAY ++ + P +MVPS+ +++ +PLT +GKVD K Sbjct: 5971 AKTDQNNDQVLCAYVVSERDITQKDIKTFLAKELPEYMVPSYLLKLDELPLTPNGKVDLK 6030 Query: 2989 KLPDSFESFQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVS 3048 LP+ S Y P++ +EEK+A +WE++L I ++G + + +G +S+ + VS Sbjct: 6031 ALPEPDRSAGALLEYEPPRHELEEKMAAIWEDILNIEQIGINANIFDIGANSLNVMSFVS 6090 Query: 3049 RL-KKYGLSLEVKELFLHQNIKGISPFVKQ 3077 RL + G + K++F IK +S F+K Sbjct: 6091 RLYAELGFRVPFKDIFSKPTIKELSDFLKH 6120 Score = 613 bits (1582), Expect = e-173, Method: Compositional matrix adjust. Identities = 403/1269 (31%), Positives = 676/1269 (53%), Gaps = 70/1269 (5%) Query: 2058 YPQSSSQKRLF--AIEQMGGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSF 2115 YP ++ QK + AIE AY ++ +EG +DP +E +F ++KRHE LR S+ Sbjct: 2545 YPLANMQKGMLFHAIEDH--TSDAYFQQTVMDIEGYVDPAILEASFNDIMKRHEILRASY 2602 Query: 2116 EL-LHDEPVQVIHDDIPFSISY-SIAEDEDEPE--LVKRFI-----LPFSLNQAPLFRVH 2166 E + +EP Q+I ++ +Y +IA+ + + ++R + F L++ L R + Sbjct: 2603 EYEIVEEPRQIIIENRSIDFTYFNIAKSSAQQQEMFIERLLNEDRKKGFDLSKDVLMRAY 2662 Query: 2167 IVSRSDHEHIVIMDMHHIIADGISANILCNDLISLY----SGENLPGLEVQ-YKDYTALH 2221 ++ ++ + ++ HHI+ DG I+ +L +Y +G+ P E + Y DY Sbjct: 2663 LLKTAERSYRLVWSHHHILLDGWCLGIIMRELFVIYENRMNGKASPLKETKPYSDYI--- 2719 Query: 2222 NEMLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKV 2281 + L + + +YW++ L LP R +D + L LT+ LK Sbjct: 2720 -KWLERQDQEEARQYWREYLKGYEEQAQLPTLTKRKKSSRYDRREKVIHLSKQLTKQLKE 2778 Query: 2282 LSNRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNY--STNNMVGMFVNTLAMR 2339 L+ + TL+T++ + ++L++Y+ +D+V G+ V+GR +M+G+F+NT+ R Sbjct: 2779 LAAKNSVTLHTVIQTIWGLMLTRYTKIDDVVFGTVVSGREANVDGIEDMIGLFINTIPTR 2838 Query: 2340 NQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERDISRNPVFDVMFVLQSLD 2399 + + F + L +V+E+ +++ E+ + +++D+ D + V ++ + Sbjct: 2839 IRFNEQARFNDCLQKVQEDAIQSNRYNYMNLAEVQALSSLKKDL-----IDHILVFENYE 2893 Query: 2400 LAVPDVHLDDIRLNGYEFKNDVAKFDLILEVIENT----ENLTLNFEYCAKLFQESTIIR 2455 D ++ G++ N+++ + + + E LTL Y ++ I Sbjct: 2894 ADEQDFEESQMK-TGFKV-NEISAAEQSITAFSMSVTPGEELTLVLTYDGNVYDRDIINN 2951 Query: 2456 MSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAA 2515 + R+ V N N +++ID+L +EE L+Y FN T YP KT++QLFEEQA Sbjct: 2952 IEGHIKRVAEQVTANENRKIAEIDMLAEEERKTLLYEFNRTNADYPRNKTIHQLFEEQAE 3011 Query: 2516 RTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEHSFELIISMFAVM 2575 RTPG A+V + E ++Y+ N ++NQ+A +LR KGVKPD VG++ E S E+I+ M AV+ Sbjct: 3012 RTPGHTAVVFEKEELSYKALNERSNQLAGLLREKGVKPDMIVGVMAERSVEMIVGMLAVL 3071 Query: 2576 KAGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQG-EFIDAASSKWYCGDD 2634 KAGGAY+PIDP YP +RI ++I+DS + I+L F + + +K ++ Sbjct: 3072 KAGGAYLPIDPEYPEDRIRYMIEDSGISILLKKADKQIDVDFTCIDMNEKGLAKDMAAEN 3131 Query: 2635 SNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYVHGEAVDFPLYSSI 2694 S +S D+AY+IYTSGSTG PKGVM HQ + N ++W ++Y + A S Sbjct: 3132 LGHTSGSS--DMAYVIYTSGSTGKPKGVMVNHQSIVNTLYWRKQSYGYSTADATLQVPSF 3189 Query: 2695 AFDLSVTLIYIPLISGNKVFIYSGVSYESL-LEAVVIDNQVDFIMLTPS-HLKILGEYDL 2752 +FD SV I+ LISG K+ + + + V+ ++ ++ PS +L +L + Sbjct: 3190 SFDSSVEDIFTTLISGAKLVLIRDLRMNPREIIGVLRTHKATNLLAVPSFYLNLLDTIEQ 3249 Query: 2753 SRLKIRKFIIGGEAFDPFYAKKFFSRLAEDVEVYNVYGPTETTVACTFYRYYPDKDLRNP 2812 +R + GE F+ ++ F +L +V+++N YGPTE +V T D + Sbjct: 3250 PLDDLRFVTVAGEGFNESLIRQHFEKLP-NVKLFNEYGPTENSVCSTRGELRKDDE---K 3305 Query: 2813 VPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREELTREKFVPDPFQTS 2872 V IG PI N ++Y+++ N +L +G PGELC++G+G++RGYLNR +LT EKFVP+PF Sbjct: 3306 VVIGRPISNHKVYILNHNQQLLPLGTPGELCLSGEGLARGYLNRPDLTLEKFVPNPFAPG 3365 Query: 2873 GMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVIISTG 2932 MYRTGDL R L DG +E+LGR+D QVKIRG RIELGEIENQL+K G++ AAV+ Sbjct: 3366 ESMYRTGDLARFLPDGQIEYLGRIDHQVKIRGFRIELGEIENQLLKIEGIDAAAVMARED 3425 Query: 2933 PTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKLPD 2992 +YLCAY AD P +MVPS+FV++ +PLTA+GK+DRK LP+ Sbjct: 3426 QAGGKYLCAYIVADKAAGVADVRKCLLKELPDYMVPSYFVKLDQLPLTANGKIDRKALPE 3485 Query: 2993 SFESFQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRL-K 3051 + E Y AP+N EEKL +WE+VLGI +G S++F +LGG S+KA + ++L K Sbjct: 3486 PSSTIS-EATYEAPRNRTEEKLVSIWEDVLGIENIGISHNFFELGGHSLKAAALTAKLHK 3544 Query: 3052 KYGLSLEVKELFLHQNIKGISPFVKQNIKRHNQGTIEGPVK-----LTAIQKWFFEQNFA 3106 + + + +++LF IK I F+ +++K +I + L++ Q+ + N Sbjct: 3545 EMKIEVPLRQLFETPTIKDIGDFI-ESMKESPYASITQAEEKEYYALSSAQRRLYILNQI 3603 Query: 3107 EMHHWNQSILLHNE---RFDVQFIRQAFQRITEHHDALRMVYRHTGQAGVEQSNRGLAGE 3163 E + ++ + FDV AF+++ E H+ALR + V++ + + Sbjct: 3604 EPGGLSYNMPFAMKIAGDFDVDRFEDAFRQLIERHEALRTAFVMVDGEPVQKIEKEVD-- 3661 Query: 3164 LFSLEVTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGLYQTTNGDYLAIV-IHHLV 3222 F ++ L D + IK K LEK PLL+ + + + +++ ++ +HH++ Sbjct: 3662 -FKVKYGRLG-----QDPLEEKIKAFIKPFALEKAPLLRAEVLKASGDEHVLMLDMHHII 3715 Query: 3223 VDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALEVYANSPKLLQELAYWTD 3282 DGVS I + A Y E L + Y+ ++E +++ ++ ++ YW + Sbjct: 3716 SDGVSMAIFTRELAELY------EGKTLPPLTIQYKDFSEWQKLFYQKDEVKRQEDYWLN 3769 Query: 3283 VNRIAVPAL 3291 V + VP L Sbjct: 3770 VFQGEVPVL 3778 Score = 591 bits (1523), Expect = e-166, Method: Compositional matrix adjust. Identities = 396/1264 (31%), Positives = 647/1264 (51%), Gaps = 60/1264 (4%) Query: 2058 YPQSSSQKRLFAIEQMGGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFEL 2117 YP S+ QK + A AY I+ ++G +D EE+ ++KRHE LR SF Sbjct: 9 YPLSNMQKGMLFHAMKDEASHAYFEQFIIELKGDVDERMFEESLNEVMKRHEILRASFHH 68 Query: 2118 LHDEPVQVIHDDIPFSISY-SIAEDEDEPELVKRFILP-----FSLNQAPLFRVHIVSRS 2171 DEP+ VI D Y I D+ +++R++ F L + L R ++ S Sbjct: 69 RLDEPLHVIIKDRHMKFDYLDIRGRHDQDGVLERYLAEDRQKGFDLAKDTLMRACLIRMS 128 Query: 2172 DHEHIVIMDMHHIIADGISANILCNDLISLY----SGENLPGLEVQ-YKDYTALHNEMLS 2226 D + + HHI+ DG I+ ++L+++Y G+N + + Y DY + L Sbjct: 129 DDSYQFVWTYHHILLDGWCLGIILDELLTIYEMKRKGQNHQLEDPRPYSDYI----KWLE 184 Query: 2227 NERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLSNRL 2286 ++ + YW+ LS +LP P F ++ +LT L L+NR Sbjct: 185 DQDKEEAQSYWESYLSGYDQKNSLP-KLRTPSETGFKRREKTIECSKELTNRLIKLANRN 243 Query: 2287 KTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNY--STNNMVGMFVNTLAMRNQPAK 2344 T+ T+L + + ++L+KY+N ED+V G+ V+GR MVG+F+NT+ R + K Sbjct: 244 HVTINTVLQSIWGVILAKYNNSEDVVFGTVVSGRDAEVEGIETMVGVFINTIPTRIRLDK 303 Query: 2345 HKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERD-ISRNPVFDVMFVLQSLDLAVP 2403 K F++ L + + + LE+ E+ + ++ D I VF+ V Q Sbjct: 304 DKLFKDVLRQTQADALESSRYNYMNLAEVQALSELKNDLIDHVMVFENYAVDQKAFEEKN 363 Query: 2404 DVHLDDIRLNGYEFKNDVAKFDLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRI 2463 DV + + ++G E N L+ + L L F Y ++ + I + + + + Sbjct: 364 DVGFEMVNVSGEEQTNYHFSISAALD-----DQLKLLFIYDENVYDTTIIETLEKHIITV 418 Query: 2464 LTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGAVAL 2523 V E+ L DI+L+ KEE R++ TFNDT T YP K +++LFEEQA +TP AL Sbjct: 419 AEQVAEDETQTLRDINLVSKEEQHRILDTFNDTKTGYPKDKPLHELFEEQAMKTPDHTAL 478 Query: 2524 VHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGAYVP 2583 V + +TY N K NQ AR+LR KG+ + I+ + SFE+II + ++KAGGAY+P Sbjct: 479 VFGAQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADRSFEMIIGIIGILKAGGAYLP 538 Query: 2584 IDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEFIDAASSKWYCGDDSNPVSVNSP 2643 IDP P RI F++ D+ ++L A+ + + I SVN Sbjct: 539 IDPETPKHRIAFMLSDTKAGVLLAQGKAADGIDCEADIIHLDKGVADGFSKKRLSSVNDS 598 Query: 2644 DDLAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYVHGEAVDFPL-YSSIAFDLSVTL 2702 D AYIIYTSGSTG+PKGV+T H V + Y+ D L S+ +FD SV Sbjct: 599 GDTAYIIYTSGSTGMPKGVVTPHYSAARVV--KNTNYIDITEDDAILQLSNYSFDGSVFD 656 Query: 2703 IYIPLISGNKVFIYSGVSYESLLEA-----VVIDNQVDFIMLTPSHLKILGEYDLSRL-K 2756 I+ L++G + + + E++L V+ QV + +T + L + ++ L K Sbjct: 657 IFGALLNGASLVL---IEKETVLNTHELAEVIKKEQVSVMFITTALFNTLADINIGCLAK 713 Query: 2757 IRKFIIGGEAFDPFYAKKFFSRLAEDVEVYNVYGPTETTVACTFYRYYPDKDLRNPVPIG 2816 +RK +GGE + +K + + D ++ +VYGPTE+TV T+Y D +PIG Sbjct: 714 LRKIFLGGERASIPHVRKVLNHVGRD-KLIHVYGPTESTVYATYYFINEIDDEAETIPIG 772 Query: 2817 GPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREELTREKFVPDPFQTSGMMY 2876 P+ N + ++D+ GKL IG+PGELCIAGDG+S+GYLNREELT EKF+P PF +Y Sbjct: 773 SPLANTSVLIMDEAGKLLPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERLY 832 Query: 2877 RTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVIISTGPTDS 2936 +TGDL + L DGN+EF+GR+D QVKIRG RIELGEIE++L +N+ V + Sbjct: 833 KTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDEESR 892 Query: 2937 RYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKLPDSFES 2996 Y+CAY TA+ ++ P +M+P++FV+M +PLT +GKVDRK LP+ + Sbjct: 893 PYICAYITANREISLDELKGFLGEKLPEYMIPAYFVKMDKLPLTKNGKVDRKALPEPDRT 952 Query: 2997 FQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRLKK-YGL 3055 E+ Y AP+N EEKLA +W ++L + K G ++ F ++GG S+KA + +R++K Sbjct: 953 AGAENEYEAPRNETEEKLAAIWRDILKVEKSGINDHFFEMGGHSLKAAAMAARIRKELKA 1012 Query: 3056 SLEVKELFLHQNIKGISPFV---KQNIKRHNQGTIEGP-VKLTAIQKWFFEQNFAEMHHW 3111 + + ++F IKG+ ++ K ++ Q E +L++ QK + + E Sbjct: 1013 EIPLGQIFKTPTIKGLGEYIRSTKDSVYSSIQKVEEKEYYRLSSAQKRLYILDQIEGSGL 1072 Query: 3112 NQSI---LLHNERFDVQFIRQAFQRITEHHDALRMVYRHTGQAGVEQSNRGLAGELFSLE 3168 + +I + RFD++ A + I + H+ALR + V++ + + FS++ Sbjct: 1073 SYNIPFTMKVKGRFDIRRFENALKTIIQRHEALRTSFLMADGEPVQKIEKEVD---FSIK 1129 Query: 3169 VTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGLYQTTNGDYLAIV-IHHLVVDGVS 3227 + + + IK + DL+K PL + + + + +++ + +HH++ DG S Sbjct: 1130 CSKIQSLS-----IQEIIKQFVRPFDLKKAPLFRTEVVKVDDEEHIILFDMHHIISDGAS 1184 Query: 3228 WRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALEVYANSPKLLQELAYWTDVNRIA 3287 ++ + Y G+E L S Y+ ++E + ++ ++ YW ++ + Sbjct: 1185 MGVLTKEICDLY----GGKE--LKPLSLQYKDYSEWQRDFYQKDEMKRQKEYWLNIFKGE 1238 Query: 3288 VPAL 3291 +P L Sbjct: 1239 IPVL 1242 Score = 323 bits (829), Expect = 4e-86, Method: Compositional matrix adjust. Identities = 168/451 (37%), Positives = 275/451 (60%), Gaps = 12/451 (2%) Query: 3555 ITDVYTMTPMQESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRT 3614 + +Y ++ MQ+ MLFHA+K++ S AY EQ I++LKGD+ + + ES ++ +++ILR Sbjct: 5 VEKIYPLSNMQKGMLFHAMKDEASHAYFEQFIIELKGDVDERMFEESLNEVMKRHEILRA 64 Query: 3615 RFVYKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGPLMR 3674 F + +L PL +++ D H++F+ + ++ +ER A DR+K FDL + LMR Sbjct: 65 SF-HHRLDEPLHVII--KDRHMKFDYLDIRGRHDQDGVLERYLAEDRQKGFDLAKDTLMR 121 Query: 3675 AILLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSLETHQ-YRLYLD 3733 A L++ D YQ +W++HHIL+DGWC+GI+L ++L Y+ G LE + Y Y+ Sbjct: 122 ACLIRMSDDSYQFVWTYHHILLDGWCLGIILDELLTIYEMKRKGQNHQLEDPRPYSDYIK 181 Query: 3734 WLASKNKEEAKVYWMQYLEDYKYKELLRKEGTSKE--FRLAVLDIKLEEKVRTAVTHVAS 3791 WL ++KEEA+ YW YL Y K L K T E F+ I+ +++ + +A+ Sbjct: 182 WLEDQDKEEAQSYWESYLSGYDQKNSLPKLRTPSETGFKRREKTIECSKELTNRLIKLAN 241 Query: 3792 SSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGRSPEIEGIERMVGLFINTIPVRVRL 3851 + +TIN+ Q++WG++L+KY+N+EDVVFG V+SGR E+EGIE MVG+FINTIP R+RL Sbjct: 242 RNHVTINTVLQSIWGVILAKYNNSEDVVFGTVVSGRDAEVEGIETMVGVFINTIPTRIRL 301 Query: 3852 -SGKTFHELAGEIQSSFISSEQYGYVPLSDIQAWSH--RDLINHVMVFENYPLDREIRDT 3908 K F ++ + Q+ + S +Y Y+ L+++QA S DLI+HVMVFENY +D++ + Sbjct: 302 DKDKLFKDVLRQTQADALESSRYNYMNLAEVQALSELKNDLIDHVMVFENYAVDQKAFE- 360 Query: 3909 DGQQMEYGFQIAGCEILEHTNYDFSIIIEPGEDFIIRIVYNALAYDKETISILESYLLAI 3968 ++ + GF++ E TNY FSI + + +Y+ YD I LE +++ + Sbjct: 361 --EKNDVGFEMVNVSGEEQTNYHFSISAALDDQLKLLFIYDENVYDTTIIETLEKHIITV 418 Query: 3969 IGQVTACPQIEAGDVEVLSQEEKLKLMNVFN 3999 QV D+ ++S+EE+ ++++ FN Sbjct: 419 AEQVAEDETQTLRDINLVSKEEQHRILDTFN 449 Score = 160 bits (406), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 104/399 (26%), Positives = 186/399 (46%), Gaps = 16/399 (4%) Query: 1352 GVVHHETVGLYLRGELNKAALETAYHKVLNRHESLRST-ISADGNEQIVASHANADIFFA 1410 G+ ++ + ++G + E A ++ RHE+LR++ + ADG ++ F+ Sbjct: 1071 GLSYNIPFTMKVKGRFDIRRFENALKTIIQRHEALRTSFLMADGEP---VQKIEKEVDFS 1127 Query: 1411 DILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIADGW 1470 + +L Q ++K+ FD PL R V+ E+++ HHII+DG Sbjct: 1128 IKCSKIQSLS----IQEIIKQFVRPFDLKKAPLFRTEVVKVDDEEHIILFDMHHIISDGA 1183 Query: 1471 SLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQPKEKAAAYWKNKFSVQ 1530 S+ V +E+ LY G + L P + DY+ WQ+ + ++ YW N F + Sbjct: 1184 SMGVLTKEICDLY-----GGKELKPLSLQYKDYSEWQRDFYQKDEMKRQKEYWLNIFKGE 1238 Query: 1531 TPAFELPSFRIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVSLFTVLLSAYKVLLYR 1590 P +P+ R +G R + +D LT KLK +++ +++ +LL+AY VLL Sbjct: 1239 IPVLNMPTDYPRPQMHSVEGDRIGFAIDGELTKKLKRIAKDNGATMYMLLLAAYTVLLRT 1298 Query: 1591 ISNHKELVVGIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXXXXXXX 1650 S +++++G P G+ KH++G +N L + TF Sbjct: 1299 YSGQEDVIIGTPIQGRKHHELKHVIGMFVNTLAMRNHPKGDKTFAEYLQDVKETALKAYE 1358 Query: 1651 XQDYSYASLMKELHSLDGSVHPPQINTMFNMDKSLETPD--FTGMDVELLQSPVSYSKYD 1708 QDY + L+++L P +TMF + ++LE D G+ E +S + SK+D Sbjct: 1359 NQDYQFDDLVEQLDLERDMSRNPLFDTMFVL-QNLEKADAEIEGLTFEPFESDIHISKFD 1417 Query: 1709 LSMNIVELDHELMIDFEYDPNLFDTQIITGWANYFNRIL 1747 L+++ +E D ++ D EY LF + + A +F R+L Sbjct: 1418 LTLSAIEKDSKIEFDLEYCTKLFKRETVERMAAHFVRVL 1456 Score = 147 bits (372), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 101/399 (25%), Positives = 176/399 (44%), Gaps = 16/399 (4%) Query: 1352 GVVHHETVGLYLRGELNKAALETAYHKVLNRHESLRSTISADGNEQIVASHANADIFFAD 1411 G+ ++ + + G+ + E A+ +++ RHE+LR+ E + D Sbjct: 3607 GLSYNMPFAMKIAGDFDVDRFEDAFRQLIERHEALRTAFVMVDGEPVQKIEKEVDF---- 3662 Query: 1412 ILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIADGWS 1471 Y LG + + + + K F PL+R VL + E++L L HHII+DG S Sbjct: 3663 -KVKYGRLGQDPLEEKI-KAFIKPFALEKAPLLRAEVLKASGDEHVLMLDMHHIISDGVS 3720 Query: 1472 LIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQPKEKAAAYWKNKFSVQT 1531 + +F +ELA LY ++L P + D++ WQK + ++ YW N F + Sbjct: 3721 MAIFTRELAELYEG-----KTLPPLTIQYKDFSEWQKLFYQKDEVKRQEDYWLNVFQGEV 3775 Query: 1532 PAFELPSFRIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVSLFTVLLSAYKVLLYRI 1591 P LP+ R +G ++ +D +A L +++ +++ +LL+ Y LL + Sbjct: 3776 PVLNLPADEKRPQKRSIEGDIVQFEIDGETSAMLNKLAKENGATMYMLLLAGYTTLLAKY 3835 Query: 1592 SNHKELVVGIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXXXXXXXX 1651 + +++VVG P AG+ KH++G +N L +M F Sbjct: 3836 TGQEDIVVGSPIAGRHHSDLKHVIGLFINTLAMRNHPKGDMPFADYLKEVKETALKAYEN 3895 Query: 1652 QDYSYASLMKELHSLDGSVHPPQINTMF---NMDKSLETPDFTGMDVELLQSPVSYSKYD 1708 QDY + L+++L P +TM N D + D G+ + LQ+ V+ SK+D Sbjct: 3896 QDYPFDELVEKLDVKRDMSRHPLFDTMLVLQNFDG--DEADIDGLTFQPLQTEVNISKFD 3953 Query: 1709 LSMNIVELDHELMIDFEYDPNLFDTQIITGWANYFNRIL 1747 L++ E + + F Y LF I A + IL Sbjct: 3954 LTLTAAETNEGIQCVFNYSTKLFKRSTIERMAGHLINIL 3992 Score = 117 bits (294), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 109/423 (25%), Positives = 190/423 (44%), Gaps = 30/423 (7%) Query: 1340 QISLVIHSNDTHGV-VHHETVGLYLRGELNKAALETAYHKVLNRHESLRSTISADGNE-- 1396 Q ++ H+ + H + + + + G ++ A LE +++ ++ RHE LR++ + E Sbjct: 2551 QKGMLFHAIEDHTSDAYFQQTVMDIEGYVDPAILEASFNDIMKRHEILRASYEYEIVEEP 2610 Query: 1397 -QIVASHANADIFFADILADYSALGDEAINQALLKEN-AAAFDSVMGPLIRLRVLATARH 1454 QI+ + + D + +I A SA E + LL E+ FD L+R +L TA Sbjct: 2611 RQIIIENRSIDFTYFNI-AKSSAQQQEMFIERLLNEDRKKGFDLSKDVLMRAYLLKTAER 2669 Query: 1455 EYLLALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQ 1514 Y L S HHI+ DGW L + ++EL +Y G S L P+SDY W LE Q Sbjct: 2670 SYRLVWSHHHILLDGWCLGIIMRELFVIYENRMNGKASPLKETKPYSDYIKW----LERQ 2725 Query: 1515 PKEKAAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYV-LDIPLTAKLKAVSQSMK 1573 +E+A YW+ +LP+ R + R R + + L LT +LK ++ Sbjct: 2726 DQEEARQYWREYLKGYEEQAQLPTLTKRKKSS-RYDRREKVIHLSKQLTKQLKELAAKNS 2784 Query: 1574 VSLFTVLLSAYKVLLYRISNHKELVVGIPTAGQMQM--GQKHLVGYCLNILPFSTTINPE 1631 V+L TV+ + + ++L R + ++V G +G+ G + ++G +N +P N + Sbjct: 2785 VTLHTVIQTIWGLMLTRYTKIDDVVFGTVVSGREANVDGIEDMIGLFINTIPTRIRFNEQ 2844 Query: 1632 MTFRXXXXXXXXXXXXXXXXQDYSYASLMKELHSLDGSVHPPQINTMFNMDK-SLETPDF 1690 F Y+Y +L E+ +L S+ I+ + + + DF Sbjct: 2845 ARFNDCLQKVQEDAIQSNR---YNYMNLA-EVQAL-SSLKKDLIDHILVFENYEADEQDF 2899 Query: 1691 ------TGMDV-ELLQSPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQIITGWANYF 1743 TG V E+ + S + + +S+ E EL + YD N++D II + Sbjct: 2900 EESQMKTGFKVNEISAAEQSITAFSMSVTPGE---ELTLVLTYDGNVYDRDIINNIEGHI 2956 Query: 1744 NRI 1746 R+ Sbjct: 2957 KRV 2959 Score = 112 bits (279), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 101/421 (23%), Positives = 189/421 (44%), Gaps = 25/421 (5%) Query: 1326 TRAPQVLKLTEEQQQISLVIHS-NDTHGVVHHETVGLYLRGELNKAALETAYHKVLNRHE 1384 T+ ++ L+ Q+ ++ H+ D + E + L+G++++ E + ++V+ RHE Sbjct: 3 TKVEKIYPLSNMQK--GMLFHAMKDEASHAYFEQFIIELKGDVDERMFEESLNEVMKRHE 60 Query: 1385 SLRSTISADGNE--QIVASHANADIFFADILADYSALGDEAINQALLKENAAAFDSVMGP 1442 LR++ +E ++ + + DI + D + + L ++ FD Sbjct: 61 ILRASFHHRLDEPLHVIIKDRHMKFDYLDIRGRHDQ--DGVLERYLAEDRQKGFDLAKDT 118 Query: 1443 LIRLRVLATARHEYLLALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTPTPFSD 1502 L+R ++ + Y + HHI+ DGW L + L EL +Y + G L P P+SD Sbjct: 119 LMRACLIRMSDDSYQFVWTYHHILLDGWCLGIILDELLTIYEMKRKGQNHQLEDPRPYSD 178 Query: 1503 YAIWQKRMLESQPKEKAAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYV-LDIPL 1561 Y W LE Q KE+A +YW++ S LP R G ++ R + + L Sbjct: 179 YIKW----LEDQDKEEAQSYWESYLSGYDQKNSLPKLRTPSETGFKR--REKTIECSKEL 232 Query: 1562 TAKLKAVSQSMKVSLFTVLLSAYKVLLYRISNHKELVVGIPTAGQMQ--MGQKHLVGYCL 1619 T +L ++ V++ TVL S + V+L + +N +++V G +G+ G + +VG + Sbjct: 233 TNRLIKLANRNHVTINTVLQSIWGVILAKYNNSEDVVFGTVVSGRDAEVEGIETMVGVFI 292 Query: 1620 NILPFSTTINPEMTFRXXXXXXXXXXXXXXXXQDYSYASL--MKELHSLDGSV--HPPQI 1675 N +P ++ + F+ Y+Y +L ++ L L + H Sbjct: 293 NTIPTRIRLDKDKLFKDVLRQTQADALESSR---YNYMNLAEVQALSELKNDLIDHVMVF 349 Query: 1676 NTMFNMDKSLETPDFTGMDVELLQSPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQI 1735 K+ E + G ++ + S + Y S++ LD +L + F YD N++DT I Sbjct: 350 ENYAVDQKAFEEKNDVGFEM-VNVSGEEQTNYHFSISAA-LDDQLKLLFIYDENVYDTTI 407 Query: 1736 I 1736 I Sbjct: 408 I 408 Score = 111 bits (278), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 85/300 (28%), Positives = 131/300 (43%), Gaps = 29/300 (9%) Query: 1801 ILDKDMHPSPVGVPGEVYLA-------RLTEPSLLAEQ--PST--------STGIMAMYT 1843 ILD+ PVG+ GE+Y++ L +P L +E+ P+ TG +A Sbjct: 5868 ILDERQEVQPVGIAGELYISGDGVAKGYLNKPELTSEKFLPNPFLPGERMYRTGDLAKMR 5927 Query: 1844 ADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAYI 1903 D I+ +G + G I L I+ QL+ H I AAV K DQ + AY+ Sbjct: 5928 PDGHIEYLGRIDHQVKIRGYRIELGEIEHQLLRHSDIKEAAVAAKTDQN--NDQVLCAYV 5985 Query: 1904 TPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALRE 1963 K +IK FL +P +PS + LDE+PL G ++ + LP D Sbjct: 5986 VSERDITQK--DIKTFLAKELPEYMVPSYLLKLDELPLTPNGKVDLKALPEPDRSAGALL 6043 Query: 1964 EIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDISLR 2023 E P +E EE++A IW ++LN+E + N + F++G NSL + E + + Sbjct: 6044 EYEPPRHELEEKMAAIWEDILNIEQIGINANIFDIGANSLNVMSFVSRLYAELGFRVPFK 6103 Query: 2024 MLFEHPTVKGLAKAINGAG---KSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGGAGTAY 2080 +F PT+K L+ + A K + + L + + K LF G AY Sbjct: 6104 DIFSKPTIKELSDFLKHAQDLLKDYTDDCMQLTRAE-----EGGKNLFCFPPAASMGIAY 6158 Score = 107 bits (267), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 100/429 (23%), Positives = 184/429 (42%), Gaps = 29/429 (6%) Query: 1340 QISLVIHS-NDTHGVVHHETVGLYLRGELNKAALETAYHKVLNRHESLRSTIS---ADGN 1395 Q ++ H+ D + E + + ++G +++ ++ ++ RHE LR++I D Sbjct: 5098 QRGMLFHALEDKESQAYFEQMAINMKGLIDERLFAETFNDIMERHEILRASIEYEITDEP 5157 Query: 1396 EQIVASHANADIFFADILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHE 1455 ++ ++ + D+ A ++ I + F PLIR ++ T Sbjct: 5158 RNVIIKDRKINLDYHDLRKQSPAEREQVIQAYRKADREKGFRLNSEPLIRAALMRTEDDS 5217 Query: 1456 YLLALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQP 1515 Y + HHI+ DGWS + + EL +Y + + L P+SDY W L+ Q Sbjct: 5218 YTFIWTNHHILLDGWSRGIIMGELFHMYHMKEARQKHRLEEARPYSDYIGW----LQQQD 5273 Query: 1516 KEKAAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYVLDIP--LTAKLKAVSQSMK 1573 KE A AYW+N S T + P + ++G K R V++ P LT ++ ++ Sbjct: 5274 KEAAKAYWRNYLSGFTE--KSPISVLAGSSGHAKYKRKEAVIEFPEQLTGRITELASRNN 5331 Query: 1574 VSLFTVLLSAYKVLLYRISNHKELVVGIPTAGQ--MQMGQKHLVGYCLNILPFSTTINPE 1631 V+ TVL + +LL R + ++V G +G+ G + +VG +N +P ++ Sbjct: 5332 VTFHTVLQCIWGMLLARYNQTDDVVFGTVISGRDAQVTGIEKMVGLFINTVPTRIRLDKS 5391 Query: 1632 MTFRXXXXXXXXXXXXXXXXQDY------SYASLMKELHSLDGSVHPPQINTMFNMDKS- 1684 +F+ D S + L +EL LD + I + +D+S Sbjct: 5392 QSFKELIKSVQEQALEGRTYHDMNLSEVQSLSELKREL--LDHIL----IFENYAVDQSA 5445 Query: 1685 LETPDFTGMDVELLQSPVSYSKYDLSMNIVELDHE-LMIDFEYDPNLFDTQIITGWANYF 1743 ET G + + + + + NIV + E L+I YD N++ II G + Sbjct: 5446 FETSGKRGAGF-VFEEIHAEEQTNYGFNIVAVPGERLVIKLTYDGNIYHDHIIAGIKGHL 5504 Query: 1744 NRILLAVLQ 1752 +++ V+Q Sbjct: 5505 QQVMEQVVQ 5513 >sp|O68006|BACA_BACLI Bacitracin synthetase 1 (BA1) [Includes: ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); ATP-dependent cysteine adenylase (CysA) (Cysteine activase); ATP-dependent leucine adenylase (LeuA) (Leucine activase); ATP-dependent glutamate adenylase (GluA) (Glutamate activase); ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); Glutamate racemase ] pir||T31677 bacitracin synthetase 1 - Bacillus licheniformis gb|AAC06346.1| bacitracin synthetase 1; BacA [Bacillus licheniformis] Length = 5255 Score = 1461 bits (3783), Expect = 0.0, Method: Compositional matrix adjust. Identities = 833/2253 (36%), Positives = 1255/2253 (55%), Gaps = 87/2253 (3%) Query: 1801 ILDKDMHPSPVGVPGEVYLA-------RLTEPSLLAEQ-------PSTS---TGIMAMYT 1843 IL+KD+ P+G GE+ +A + P L E+ P TG +A Sbjct: 2437 ILNKDLQLCPLGASGELCIAGEGLARGYVNRPELTREKFIGNPFVPGERMYRTGDLAKML 2496 Query: 1844 ADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAYI 1903 D I+ +G + + G I I+ +L+ + I AAV + G D + AY+ Sbjct: 2497 PDGNIQFLGRVDQQVKIRGYRIEPGEIENRLLKYEKIEEAAVIAREDG--DHDPYLCAYV 2554 Query: 1904 TPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALRE 1963 T + P+ +I+ FL +P IP F+ LD +PL G ++++ LP + + Sbjct: 2555 TVKKEVEPE--KIRAFLKKSLPDYMIPQYFVQLDGLPLTVNGKVDKKSLPVPERSVTMDR 2612 Query: 1964 EIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDISLR 2023 P ++ EE+L IW L + + N FFE GG+SLKA+ L +I KE + + LR Sbjct: 2613 RYEAPRDQMEEKLVSIWEEALGINKIGINSHFFEAGGHSLKAAALVSTIHKELNVKLPLR 2672 Query: 2024 MLFEHPTVKGLAKAINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGGAGTAYNIT 2083 +FE PT+KGL K F + +K +Y SS+QKRL+ + Q G + AYN+ Sbjct: 2673 QIFETPTIKGLRDISVRRRKCFYID-RKTEEKPYYRLSSAQKRLYILSQTG-SHVAYNMP 2730 Query: 2084 GILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSISYSIAEDED 2143 + +EG D R E + +VKRHE RTSF ++ E +Q I +I F ++YS E Sbjct: 2731 FAMTLEGDFDIRRFENTLKNMVKRHESFRTSFVMIDGEVMQQIEKEIDFQVAYSDIGKES 2790 Query: 2144 EPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGISANILCNDLISLYS 2203 E +K FI PF L +APL R +V ++ EH+++ DMHHII+DG+S +I +L +LY Sbjct: 2791 AEEKIKSFIRPFHLEKAPLLRAEVVKLNEREHLLMFDMHHIISDGVSTDIFIQELGALYE 2850 Query: 2204 GENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFD 2263 G++L +QYKDY N +E +++Q EYW + DIP L LP+D RP +S + Sbjct: 2851 GKSLKPFHIQYKDYAEWENSHARSEELKRQEEYWLKTYKGDIPVLDLPIDHKRPLTKSSE 2910 Query: 2264 GACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNY 2323 G + ++S+ R L+ ++ T+Y LLLA Y LLSKY+ QEDI++G+P AGR + Sbjct: 2911 GDTVTAAIESETFRKLQHMAKENGVTMYMLLLAGYTALLSKYTGQEDIIVGTPAAGRNHE 2970 Query: 2324 STNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERDI 2383 +++GMFVNTLA+RN P KTF+++L EVKENTL+A+ENQDYPFEEL+ K+ I+RD+ Sbjct: 2971 DIQHLIGMFVNTLAIRNHPEGKKTFRDYLQEVKENTLQAYENQDYPFEELVEKVNIKRDM 3030 Query: 2384 SRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKFDLILEVIENTENLTLNFEY 2443 +RNP+FD M V + D V + +R E K ++KFD+ + E + L L EY Sbjct: 3031 ARNPLFDTMLVYHNTD--VKPFEAEGLRSRLVEIKRGISKFDITVTASEAADGLRLEVEY 3088 Query: 2444 CAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGG 2503 LF + + R+SE + +L ++ ++ ++ ID+L K E R++Y FN T + Sbjct: 3089 STTLFNKERMERLSEHLISLLEQAADHPDIAINQIDVLTKGERHRVLYDFNRTDGVFCKE 3148 Query: 2504 KTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEH 2563 T+ +LFE+QA +TP A+ E+I+Y N + N +A LR KGV PD GIL E Sbjct: 3149 MTIPELFEKQAEKTPDHPAVAFGDETISYRELNERANSLAFTLRQKGVGPDVIAGILTER 3208 Query: 2564 SFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEF-- 2621 S E+I+ + ++KAGGAY+PIDP YP ERI++I+KDS++ ++ + + G+ Sbjct: 3209 SIEMIVGIMGILKAGGAYLPIDPAYPQERISYIVKDSDVSVLCAAGDVDPGEAYTGDIIR 3268 Query: 2622 IDAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVW-WGDKTY 2680 ID + + + + P LAY+IYTSGSTG PKGVM H + N V ++ Y Sbjct: 3269 IDQTGQNDHVENLKHDI---KPQHLAYVIYTSGSTGKPKGVMIEHHSVNNLVHGLNERIY 3325 Query: 2681 VHGEA-VDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSGVSYESLLEAVVI-----DNQV 2734 H +A ++ L + FD SV I+ L+ G+ + I V E+ +A+ + N + Sbjct: 3326 QHLDAHLNVALVAPYIFDASVKQIFAALLFGHTLCI---VPRETAWDAMSLIEYYSKNNI 3382 Query: 2735 DFIMLTPSHLKILGEYDLSRLK--IRKFIIGGEAFDPFYAKKFFSRLAE-DVEVYNVYGP 2791 + +TP+HL +L D + L+ +++ I+GG+A P F + + NVYGP Sbjct: 3383 NVSDMTPAHLNMLAYVDKTELEFDVKELIVGGDALTPDVIGGLFHKFPNLSCNITNVYGP 3442 Query: 2792 TETTVACTFYRYYPDKDLRNP-VPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVS 2850 TE V ++ K + P +PIG P+ N +Y+VD+ + +GI GELCIAG+GV+ Sbjct: 3443 TECCVDAASHQIESGKVPQTPSIPIGRPLLNTSIYIVDKELRPLPVGIAGELCIAGEGVA 3502 Query: 2851 RGYLNREELTREKFVPDPFQTSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELG 2910 RGY+NR ELT EKFV PF+ MY+TGDL L DG +EFLGR D QVKIRG+RIELG Sbjct: 3503 RGYVNRPELTAEKFVDHPFEPGKKMYKTGDLAMWLPDGQIEFLGRADHQVKIRGYRIELG 3562 Query: 2911 EIENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSF 2970 E+E QL+ + +AAVI + YLCAY +D + P +M+PS+ Sbjct: 3563 EVEQQLLTHEKIKEAAVIAGKDQNGNSYLCAYIASDKELPAADVRQFLEREMPDYMIPSY 3622 Query: 2971 FVQMKSIPLTASGKVDRKKLPDSFESFQMED--AYSAPQNFIEEKLALVWEEVLGINKVG 3028 FV++ +P T SGKVDR LP++ + + + Y P+N IE KL VW E+LG +G Sbjct: 3623 FVKLDRLPRTPSGKVDRSALPEADGNVNVMEGTGYDPPRNEIERKLVQVWREILGAEDIG 3682 Query: 3029 TSNSFIKLGGDSIKAIQIVSRLKKYGLSLEVKELFLHQNIKGISPFVKQNI--KRHNQGT 3086 S+ F GGDSIKA+QIVSRL K L LE+K LF + IK +S F+ + ++HN+ Sbjct: 3683 ISHHFFAAGGDSIKALQIVSRLAKMNLKLEMKALFANPKIKDLSRFITEETRHRKHNK-P 3741 Query: 3087 IEGPVKLTAIQKWFFEQNFAEMHHWNQSILL-HNERFDVQFIRQAFQRITEHHDALRMVY 3145 + G +L IQK +F N E+ H+NQS +L + +D +R AF +I E HDALRM+Y Sbjct: 3742 VTGETELLPIQKRYFANNKEELDHFNQSFMLFRKDGYDENIVRTAFNKILEQHDALRMIY 3801 Query: 3146 RHTGQAGVEQSNRGLAGELFSLEVTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGL 3205 + Q NRG LF L+V D+ G D + + IQK + KG L+ LG+ Sbjct: 3802 EEK-DGDIIQYNRGYRENLFDLDVYDVRGFDSQEEKVFELATGIQKKSSIRKGKLVHLGI 3860 Query: 3206 YQTTNGDYLAIVIHHLVVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALE 3265 ++ GD+L I IHHLVVDGVSWRI+ +DF + YL GE + K+DSYQ++A L+ Sbjct: 3861 FRADEGDHLLIAIHHLVVDGVSWRILFEDFETLYLQALKGEPLDIGYKTDSYQEFARQLK 3920 Query: 3266 VYANSPKLLQELAYWTDVNRIAVPALPKDSEAGNGKIKDRYQTKTVLSEK----ETTNLL 3321 YA S +LL+E YW VP +P + +D ++ LS + T LL Sbjct: 3921 KYAQSRRLLKEREYWQKALEADVPFIPAEKLE-----RDTFEHSATLSIRIGPDVTAKLL 3975 Query: 3322 RHAGDAYQTETXXXXXXXXXXXIKGWANVDRVRINMEGHGREALIQDLDITRTVGWFTST 3381 R+A AY TE ++ +++++ MEGHGRE ++ +DITRT+GWFT+ Sbjct: 3976 RNAFKAYNTEINDILLTALIAAVRDITGENKLKVMMEGHGREDILDGVDITRTIGWFTTV 4035 Query: 3382 YPLVLELANSHELPLHIMTTKETIRQTPNKGMGYQVLKYLTSPELRAAVDFNVMPEISFN 3441 YP+ ++L E+ +I KE +R+ PNKG+GY VLKY+T EL+ +SFN Sbjct: 4036 YPVFIDLGEEKEISQNIKMVKEALRKIPNKGIGYGVLKYMTE-ELQK---IQTQAPLSFN 4091 Query: 3442 YLGQFGNEASYGTFEICNTFMESTESPESH------RPYAIDINAMIVGNRVEIRVDYNP 3495 Y G+ N+ + F +S SP R AI++NA+ + + I +N Sbjct: 4092 YFGEMNNDMNR------KVFSQSPFSPGESIGGKIVRHCAIEMNAISLNGELTIYTTFNQ 4145 Query: 3496 GQFNEATMSRFAELLLNSLKLIISHCTREERIQRSPSDLTYKKLTFEELDDLNRLYPG-G 3554 Q+ +T+ + + +L+ I+ HC +E +PSD L EEL+ + Y Sbjct: 4146 DQYQTSTIEQLNQSFKENLEKIVDHCVDKEGSDMTPSDYGDVSLGLEELELIKDKYSAFQ 4205 Query: 3555 ITDVYTMTPMQESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRT 3614 I +Y + MQ+ MLFH ++ S AY +Q ++ LKG + ++L ESF IV +++ILR Sbjct: 4206 IEKIYPLANMQKGMLFHNAMDQTSGAYFQQIVIKLKGRVHPDILEESFHEIVKRHEILRA 4265 Query: 3615 RFVYKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGPLMR 3674 F Y+ P QI+ D+T + + +E D+EK FDL LMR Sbjct: 4266 SFEYEITAEPRQIIARDRKTPFTSIDLTGENRTRQHRFIETYLKEDQEKGFDLSSEALMR 4325 Query: 3675 AILLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAG-SRPSLETHQYRLYLD 3733 L+K D Y+++WS HHIL+DGWC+GIVL ++ Y ++ G SR E Y Y+ Sbjct: 4326 VCLIKMSDESYRLIWSHHHILLDGWCLGIVLSELFSLYGKIMKGESRRLKEPKPYGDYIK 4385 Query: 3734 WLASKNKEEAKVYWMQYLEDYKYKELL---RKEGTSKEFRLAVLDIKLEEKVRTAVTHVA 3790 WL +++EEA YW YL+ Y+ + L + TS+E+ I +++ T +T +A Sbjct: 4386 WLEKQDQEEAVAYWKDYLKGYESRSELPAFNRGATSEEYCGKEKVISFSKELTTKITRIA 4445 Query: 3791 SSSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGRSPEIEGIERMVGLFINTIPVRVR 3850 +TIN+ Q +WG++L+KY N ++VVFG V+SGR ++GIE MVGLFI+TIP R+ Sbjct: 4446 KQHHVTINTVLQGIWGMILAKYKNTDEVVFGTVVSGREAPVDGIEEMVGLFIHTIPTRIS 4505 Query: 3851 LSG-KTFHELAGEIQSSFISSEQYGYVPLSDIQAWSH--RDLINHVMVFENYPLDREIRD 3907 G ++F E+ + Q+ I S +Y Y+ LS+IQ S R+LI HVM F+NY D E+ Sbjct: 4506 FEGARSFKEVLKKTQAESIESNRYSYMNLSEIQVLSEMKRELITHVMAFQNYAFDEELFR 4565 Query: 3908 TDGQQMEYGFQIAGCEILEHTNYDFSII-IEPGEDFIIRIVYNALAYDKETISILESYLL 3966 + Q E GF++ G E TNY+F++ + E +++ +N YD I LE +++ Sbjct: 4566 S--QSGETGFELEGVHGKERTNYNFNLTGVLEDEQLKLKLTFNENVYDNTIIETLEKHII 4623 Query: 3967 AIIGQVTACPQIEAGDVEVLSQEEKLKLMNVFN 3999 + QV D+ ++S+EE+ ++++ FN Sbjct: 4624 TVAEQVAEDETQTLRDINLVSKEEQHRILHTFN 4656 Score = 889 bits (2297), Expect = 0.0, Method: Compositional matrix adjust. Identities = 571/1780 (32%), Positives = 942/1780 (52%), Gaps = 100/1780 (5%) Query: 1789 YGVSWDEADIFVILDKDMHPSPVGVPGEVYLA------------RLTEPSLLAEQP---S 1833 YG I+V L+++ PVGV GE+Y+ TE S + Q Sbjct: 1388 YGKPLANQKIYV-LNQNKQLCPVGVEGELYIGGAGVASGYIHDQEKTEHSFIQHQELGYI 1446 Query: 1834 TSTGIMAMYTADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVT--VKPSG 1891 TG + D ++ +G + G + + I+ LV H I A+V P G Sbjct: 1447 YKTGDYGVLKEDGYVEFLGRKDSQVKIRGYRVEMGEIENTLVSHQEITKASVIDYTSPDG 1506 Query: 1892 TFQRDQKILAYITPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERL 1951 + + A++ +I ++ ++K+FL +P IP+ F+ ++EIPL G +++R Sbjct: 1507 I----KNLYAFVVAE-NAISQL-DVKEFLQKTLPDYMIPAKFVQIEEIPLTVNGKVDKRT 1560 Query: 1952 LPAFDE----DKALREEIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASL 2007 L E D+ R MLPENET+ L EIW+++ L+ +N + ++E+GG+SLKA Sbjct: 1561 LHDLAEQHTADEGQRGGRMLPENETQAMLLEIWKDIFGLDSINLDVSYYEIGGDSLKAIS 1620 Query: 2008 LAFSIQKEFSTDISLRMLFEHPTVKGLAKAINGAGKSFLPE-ITPLGKKDWYPQSSSQKR 2066 + I K + ++ + +F++ T+ L + +S + I +K++YP S +Q+R Sbjct: 1621 IITEINKRMNVEMPISEIFKNDTIIALDHYLKNREESDMEHPIQKAREKEYYPTSPAQQR 1680 Query: 2067 LFAIEQMGGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVI 2126 ++ + + AY+I L VEG+++ ++E A + ++RHE LRT FE+ ++E +Q I Sbjct: 1681 MYMLSMLENERGAYHIPMALLVEGRINAMQLENALKTFLQRHEILRTGFEIQNNELIQKI 1740 Query: 2127 HDDIPFSISY-----SIAEDEDEPELVKRF----ILPFSLNQAPLFRVHIVSRSDHEHIV 2177 ++++ F + Y SI + E+ R+ I PF L++ PL R ++ D HI+ Sbjct: 1741 YENVDFRLEYECLDASITDQHALMEITSRYCKESIKPFDLSRPPLMRAKLIKIDDIRHIL 1800 Query: 2178 IMDMHHIIADGISANILCNDLISLYSGENLPGLEVQYKDYTALHNEMLSNERIRQQGEYW 2237 +++ HHII+DG+S IL N+++ LYS LP + VQYKDY ++ + +++Q YW Sbjct: 1801 VINFHHIISDGVSQGILMNEILELYSNVPLPEVNVQYKDYVEWNHTFNQSAAMKKQEAYW 1860 Query: 2238 QQLLSDDIPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLAS 2297 + D L P D+ R + +F+G+ + ++ +L+ ++ L+ TTLYT++L++ Sbjct: 1861 LDVYRDIPSKLDFPYDYKRHHIDTFEGSSVFLEMERELSDHIRKLAKHNGTTLYTVMLSA 1920 Query: 2298 YNILLSKYSNQEDIVIGSPVAGRFNYSTNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKE 2357 Y +LL+KY+NQ DIV+G+ AGR + ++ G+FVNTLA+RN+ +F+EFL + KE Sbjct: 1921 YYVLLNKYTNQTDIVVGTAAAGRLHPDLQDVFGVFVNTLALRNEVDTSYSFKEFLQQTKE 1980 Query: 2358 NTLEAFENQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEF 2417 T+ AF+N +YPF++LI KL R+ +RNP+FD MFVL+ D + D++L+ F Sbjct: 1981 RTIAAFDNSEYPFDDLIRKLNGVRESNRNPLFDTMFVLE--DARMFTKQKGDVKLSPIIF 2038 Query: 2418 KNDVAKFDLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSD 2477 + D AKFD+I V++ + + LN EY LF++ TI +++E + RIL V EN +V L Sbjct: 2039 ELDNAKFDMIFNVLDFEQKIVLNIEYSTSLFKDETIQKIAEDYFRILEEVSENLDVALHQ 2098 Query: 2478 IDLLPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGAVALVHQGESITYEHFNR 2537 ID++ ++E L+ +FN T TAYP GK ++QLFEEQA R P A+V + + +TY N Sbjct: 2099 IDMISRQEKRTLLESFNHTKTAYPKGKAIHQLFEEQAKRIPDHTAVVFEDQKLTYRQLNE 2158 Query: 2538 KTNQMARMLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGAYVPIDPTYPSERINFII 2597 K NQ+AR+LR KGVKPDT VGI+ME S ++I ++ V+KAGGAY+PIDP YP ER+ ++ Sbjct: 2159 KANQVARLLREKGVKPDTLVGIMMERSSDMIAAILGVLKAGGAYLPIDPEYPPERMRYMA 2218 Query: 2598 KDSNLEIMLTHKGLAEKCQFQG-EFIDAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGST 2656 DS ++++++ LAE+ + E I + D S+ +VN DLAY+IYTSGST Sbjct: 2219 FDSEVKVIISDVPLAEELTAESIELIHMDDERIAGQDRSDIDNVNQSGDLAYVIYTSGST 2278 Query: 2657 GLPKGVMTRHQGLTNYVWWGDKTYVHGEAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIY 2716 G PKGVM HQ L N W + G+ + +Y+SI+FD V ++ + +G V + Sbjct: 2279 GKPKGVMIEHQSLINLCSWHQSCFEVGQNDNSSIYASISFDAFVWELFPYITAGATVHV- 2337 Query: 2717 SGVSYESLLEAVVIDNQVDFIMLTPSHL--KILGEYD-LSRLKIRKFIIGGEAFDPFYAK 2773 ++ E+ L+ ++ +T S L + ++ L +R + GG+ + F K Sbjct: 2338 --LNQETRLDVEKLNRYFHDHHITISFLPTPVCEQFTALDNHSLRTLLTGGDKLNVFKEK 2395 Query: 2774 KFFSRLAEDVEVYNVYGPTETTVACTFYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNGKL 2833 + ++ N YGPTE TV T + DK +N +PIG PI NV++Y+++++ +L Sbjct: 2396 SY--------QIVNNYGPTENTVVATSFPI--DKSHQN-IPIGKPIDNVKVYILNKDLQL 2444 Query: 2834 QGIGIPGELCIAGDGVSRGYLNREELTREKFVPDPFQTSGMMYRTGDLVRMLQDGNVEFL 2893 +G GELCIAG+G++RGY+NR ELTREKF+ +PF MYRTGDL +ML DGN++FL Sbjct: 2445 CPLGASGELCIAGEGLARGYVNRPELTREKFIGNPFVPGERMYRTGDLAKMLPDGNIQFL 2504 Query: 2894 GRMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTADFPMNXXX 2953 GR+D QVKIRG+RIE GEIEN+L+K + +AAVI YLCAY T + Sbjct: 2505 GRVDQQVKIRGYRIEPGEIENRLLKYEKIEEAAVIAREDGDHDPYLCAYVTVKKEVEPEK 2564 Query: 2954 XXXXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIEEK 3013 P +M+P +FVQ+ +PLT +GKVD+K LP S M+ Y AP++ +EEK Sbjct: 2565 IRAFLKKSLPDYMIPQYFVQLDGLPLTVNGKVDKKSLPVPERSVTMDRRYEAPRDQMEEK 2624 Query: 3014 LALVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRL-KKYGLSLEVKELFLHQNIKGIS 3072 L +WEE LGINK+G ++ F + GG S+KA +VS + K+ + L ++++F IKG+ Sbjct: 2625 LVSIWEEALGINKIGINSHFFEAGGHSLKAAALVSTIHKELNVKLPLRQIFETPTIKGLR 2684 Query: 3073 PFVKQNIKRH-----NQGTIEGP-VKLTAIQKWFFEQNFAEMH-HWNQSILLHNE-RFDV 3124 +++R ++ T E P +L++ QK + + H +N + E FD+ Sbjct: 2685 DI---SVRRRKCFYIDRKTEEKPYYRLSSAQKRLYILSQTGSHVAYNMPFAMTLEGDFDI 2741 Query: 3125 QFIRQAFQRITEHHDALRMVYRHTGQAGVEQSNRGLAGELFSLEVTDLTGCDDHTDLMHA 3184 + + + + H++ R + ++Q + + F + +D+ + Sbjct: 2742 RRFENTLKNMVKRHESFRTSFVMIDGEVMQQIEKEID---FQVAYSDIG-----KESAEE 2793 Query: 3185 GIKTIQKGIDLEKGPLLKLGLYQTTNGDYLAIV-IHHLVVDGVSWRIILDDFASCYLSLD 3243 IK+ + LEK PLL+ + + ++L + +HH++ DGVS I + + + Y Sbjct: 2794 KIKSFIRPFHLEKAPLLRAEVVKLNEREHLLMFDMHHIISDGVSTDIFIQELGALY---- 2849 Query: 3244 NGEEAGLIEKSDSYQKWAEALEVYANSPKLLQELAYWTDVNRIAVPA--LPKDSEAGNGK 3301 E L Y+ +AE +A S +L ++ YW + +P LP D + K Sbjct: 2850 --EGKSLKPFHIQYKDYAEWENSHARSEELKRQEEYWLKTYKGDIPVLDLPIDHKRPLTK 2907 Query: 3302 IKDRYQTKTVLSEKETTNLLRHAGDAYQTETXXXXXXXXXXXIKGWANVDRVRINMEGHG 3361 + T T E ET L+H + + + + + G Sbjct: 2908 SSEG-DTVTAAIESETFRKLQHMAKENGVTMYMLLLAGYTALLSKYTGQEDIIVGTPAAG 2966 Query: 3362 REALIQDLDITRTVGWFTSTYPLVLELANSHELPLHIMTTKE-TIRQTPNKGMGYQVLKY 3420 R DI +G F +T + ++ KE T++ N+ ++ L Sbjct: 2967 R----NHEDIQHLIGMFVNTLAIRNHPEGKKTFRDYLQEVKENTLQAYENQDYPFEEL-- 3020 Query: 3421 LTSPELRAAVDFNVMPEISFNYLGQFGNEASYGTFEICNTFMESTESPESHRPYAIDINA 3480 + ++ + N + + Y + FE E + I + A Sbjct: 3021 VEKVNIKRDMARNPLFDTMLVY-----HNTDVKPFEAEGLRSRLVEIKRGISKFDITVTA 3075 Query: 3481 MIVGNRVEIRVDYNPGQFNEATMSRFAELLLNSLKLIISH 3520 + + + V+Y+ FN+ M R +E L++ L+ H Sbjct: 3076 SEAADGLRLEVEYSTTLFNKERMERLSEHLISLLEQAADH 3115 Score = 552 bits (1422), Expect = e-155, Method: Compositional matrix adjust. Identities = 347/1046 (33%), Positives = 557/1046 (53%), Gaps = 46/1046 (4%) Query: 2058 YPQSSSQKRLFAIEQMGGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFEL 2117 YP ++ QK + M AY ++ ++G++ P +EE+F +VKRHE LR SFE Sbjct: 4210 YPLANMQKGMLFHNAMDQTSGAYFQQIVIKLKGRVHPDILEESFHEIVKRHEILRASFEY 4269 Query: 2118 -LHDEPVQVIHDD--IPF-SISYSIAEDEDEPELVKRFILP-----FSLNQAPLFRVHIV 2168 + EP Q+I D PF SI + + ++ ++ F L+ L RV ++ Sbjct: 4270 EITAEPRQIIARDRKTPFTSIDLTGENRTRQHRFIETYLKEDQEKGFDLSSEALMRVCLI 4329 Query: 2169 SRSDHEHIVIMDMHHIIADGISANILCNDLISLY----SGENLPGLEVQ-YKDYTALHNE 2223 SD + +I HHI+ DG I+ ++L SLY GE+ E + Y DY + Sbjct: 4330 KMSDESYRLIWSHHHILLDGWCLGIVLSELFSLYGKIMKGESRRLKEPKPYGDYI----K 4385 Query: 2224 MLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLS 2283 L + + YW+ L LP + + G ++ +LT + ++ Sbjct: 4386 WLEKQDQEEAVAYWKDYLKGYESRSELPAFNRGATSEEYCGKEKVISFSKELTTKITRIA 4445 Query: 2284 NRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFN--YSTNNMVGMFVNTLAMRNQ 2341 + T+ T+L + ++L+KY N +++V G+ V+GR MVG+F++T+ R Sbjct: 4446 KQHHVTINTVLQGIWGMILAKYKNTDEVVFGTVVSGREAPVDGIEEMVGLFIHTIPTRIS 4505 Query: 2342 PAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERDISRNPVFDVM-FVLQSLDL 2400 ++F+E L K+ E+ E+ Y + L S++ + ++ R + VM F + D Sbjct: 4506 FEGARSFKEVL---KKTQAESIESNRYSYMNL-SEIQVLSEMKRELITHVMAFQNYAFD- 4560 Query: 2401 AVPDVHLDDIRLNGYEFK----NDVAKFDLILEVIENTENLTLNFEYCAKLFQESTIIRM 2456 ++ G+E + + ++ L + E L L + ++ + I + Sbjct: 4561 --EELFRSQSGETGFELEGVHGKERTNYNFNLTGVLEDEQLKLKLTFNENVYDNTIIETL 4618 Query: 2457 SERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAAR 2516 + + + V E+ L DI+L+ KEE R+++TFNDT T YP K +++LFEEQA + Sbjct: 4619 EKHIITVAEQVAEDETQTLRDINLVSKEEQHRILHTFNDTKTGYPKDKPLHELFEEQAMK 4678 Query: 2517 TPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEHSFELIISMFAVMK 2576 TP ALV + +TY N K NQ AR+LR KG+ + I+ + SFE+II + ++K Sbjct: 4679 TPDHTALVFGAQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADRSFEMIIGIIGILK 4738 Query: 2577 AGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEFIDAASSKWYCGDDSN 2636 AGG Y+PIDP P +RI++++K+S +++T L + F + +D S + + + N Sbjct: 4739 AGGTYLPIDPETPRDRIDYMLKNSGAALLVTTDSLLKP--FDIKTVDLCSDELHLLSEEN 4796 Query: 2637 PVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYVHGEAVDFPLYSSIAF 2696 VN D AYI+YTSGSTG PKGV+ H V + + G V L S+ +F Sbjct: 4797 LPRVNRSSDTAYIVYTSGSTGTPKGVVIPHYSAARVVKNTNYIDITGNDVILQL-SNYSF 4855 Query: 2697 DLSVTLIYIPLISGNKVFIYSGVSYESLLEA-----VVIDNQVDFIMLTPSHLKILGEYD 2751 D SV I+ L++G + + + E++L V+ QV + +T + L + + Sbjct: 4856 DGSVFDIFGALLNGASLVL---IEKETVLNTHELAEVIKKEQVSVMFITTALFNTLADIN 4912 Query: 2752 LSRL-KIRKFIIGGEAFDPFYAKKFFSRLAEDVEVYNVYGPTETTVACTFYRYYPDKDLR 2810 + L K+RK + GGE + +K + D ++ +VYGPTE+TV T+Y D Sbjct: 4913 IGCLAKLRKILFGGERASIPHVRKVLDHVGRD-KLIHVYGPTESTVYATYYFINEIDDEA 4971 Query: 2811 NPVPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREELTREKFVPDPFQ 2870 +PIG P+ N + ++D+ GKL IG+PGELCIAGDG+S+GYLNREELT EKF+P PF Sbjct: 4972 ETIPIGSPLANTSVLIMDEAGKLLPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFI 5031 Query: 2871 TSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVIIS 2930 +Y+TGDL + L DGN+EF+GR+D QVKIRG RIELGEIE++L +N+ V + Sbjct: 5032 PGERLYKTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVR 5091 Query: 2931 TGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKL 2990 Y+CAY TA+ ++ P +M+P++FV+M +PLT +GKVDRK L Sbjct: 5092 EDEESRPYICAYITANREISLDELKGFLGEKLPDYMIPAYFVKMDKLPLTKNGKVDRKAL 5151 Query: 2991 PDSFESFQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRL 3050 P+ S E Y AP+N++E+++ + E+VLG ++G S F GG+S+KA+Q V + Sbjct: 5152 PEPDRSAGTEAEYEAPRNYVEQRIISILEDVLGTERMGISCHFFDKGGNSLKAMQAVHSI 5211 Query: 3051 KK-YGLSLEVKELFLHQNIKGISPFV 3075 K +G+ + + F H K ++ FV Sbjct: 5212 NKTFGIDMRISTFFKHPTAKSLARFV 5237 Score = 503 bits (1295), Expect = e-140, Method: Compositional matrix adjust. Identities = 449/1695 (26%), Positives = 775/1695 (45%), Gaps = 164/1695 (9%) Query: 1800 VILDKDMHPSPVGVPGEVYLA-------RLTEPSLLAEQ-------PST---STGIMAMY 1842 +I+D+ P+GVPGE+ +A L L AE+ P TG +A + Sbjct: 359 LIMDEAGKLVPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERLYKTGDLAKW 418 Query: 1843 TADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAY 1902 D I+ IG + G I L I+ +L +H I VTV+ + I AY Sbjct: 419 LPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDE--ESRPYICAY 476 Query: 1903 ITP-RGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKAL 1961 IT R S+ E+K FL ++P IP+ F+ LD++PL G ++ + LP D Sbjct: 477 ITANREISLD---ELKGFLGEKLPEYMIPAYFVKLDKLPLTKNGKVDRKALPEPDRTAGA 533 Query: 1962 REEIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDIS 2021 E P NETEE+LA +W++VL++E +D F ++GG+SL A L I+++ + +I Sbjct: 534 ENEYEAPRNETEEKLAAVWQDVLHVEKAGIHDHFAQMGGHSLHAMELIAKIKEKMNVEIP 593 Query: 2022 LRMLFEHPTVKGLAKAING-----AGKSFLPEIT-PLGKKDWYPQSSSQKRLFA--IEQM 2073 L LF+ T+K L+ I G + + P + +P + Q E Sbjct: 594 LHQLFKLATIKELSAFIEANHQEDKGDTLVTRAADPENIHEIFPLTGIQLAYLVGRDETF 653 Query: 2074 GGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFS 2133 G A N+T + E +D R + Q+L+ RH LRT ++ + Q I + + Sbjct: 654 EIGGVATNLT--VEFEADVDLNRFQLTLQKLIDRHPILRT---IVFENGTQKI---LEAT 705 Query: 2134 ISYSIAED---------------EDEPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVI 2178 Y+I E ++ + I P + PLF + + Sbjct: 706 QRYTIETQDLRGFTEEEINVRILEQREKMTSKIIDP---SVWPLFELKTFMLPGEKKYFF 762 Query: 2179 MDMHHIIADGISANILCNDLISLYS--GENLPGLEVQYKDYTALHNEMLSNERIRQQGEY 2236 +++ +I D S L + LY G LP LE ++DY R ++ +Y Sbjct: 763 LNVDPLICDDSSMKRLIREFKQLYENPGLQLPSLEYSFRDYVLASINFKQTSRYQKDQQY 822 Query: 2237 WQQLLSDDIPSL-TLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLL 2295 W L D PS LPL V +S LD LK + T ++L Sbjct: 823 WLDKL-DHFPSAPELPLKSDPAHVAKPSFKKFSTFLDGHTWNELKKKARHHHLTPTSVLC 881 Query: 2296 ASYNILLSKYSNQEDIVIGSPVAGR--FNYSTNNMVGMFVNTLAMRNQPAKH-KTFQEFL 2352 A+Y +L+ +S Q I V R F+ NM+G F + + + ++ +F F Sbjct: 882 AAYAYILAYWSRQNHFAINLTVFNRIPFHPDVKNMIGDFTSLMLLDIHAEENMSSFWRFA 941 Query: 2353 LEVKENTLEAFENQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLDDIRL 2412 L V++ LEA E++ Y ++I + + +++ V ++F S+ PD D + Sbjct: 942 LNVQDTLLEALEHRHYDGVDVIRNIAKKNGMNKKAVMPIVFT--SVLSENPDDSFDSLVD 999 Query: 2413 --NGYEFKNDVAKFDLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTTVVEN 2470 N + F ++ + +V E L + ++Y ++F+ I M ++++ ++ V Sbjct: 1000 FDNIHFFSTRTSQVYIDNQVYEINGGLYITWDYVEQIFEHEVIESMFDQYIAVIQKAVSG 1059 Query: 2471 CNVLLSDIDLLPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGAVALVHQGESI 2530 +V S I + E++ ++I +NDT ++ K +++LF Q P +AL H E + Sbjct: 1060 EDV--STIQM--NEKSRQMISAYNDTDQSF-DAKPLHELFTGQVKHGPDRMALKHHDEVM 1114 Query: 2531 TYEHFNRKTNQMARMLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGAYVPIDPTYPS 2590 TY+ + K+NQ+AR L KGV+ +G++ + S I+++ AV+K G AY+P+DP YP Sbjct: 1115 TYQELDEKSNQVARFLIGKGVEKGDYIGVIGKRSLGTIVNLLAVLKTGAAYIPLDPDYPE 1174 Query: 2591 ERINFIIKDSNLEIMLTHKGLAEKCQFQGEFIDAASSKWYCGDDSNPVSVNSP-DDLAYI 2649 ER +I SN + ++H + E I+ S PV DD+AY+ Sbjct: 1175 ERKAYIQSKSNCKFFISHD------VYDKEHIERFSKA--------PVDRKVDLDDMAYV 1220 Query: 2650 IYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYVHGEAVDFPLYSSIAFDLSVTLIYIPLIS 2709 I+TSGSTG PKGV H N + ++ + E + SS+ FDLSV ++ L S Sbjct: 1221 IFTSGSTGKPKGVQITHVPQRNTILDINEKFNVTEQDNIMGISSLCFDLSVYDVFGALSS 1280 Query: 2710 GNKVFIYS------GVSYESLLEAVVIDNQVDFIMLTPSHLKILGEYDLSRLKIRKFIIG 2763 G + I + + E + I N V IM + + + +L+ +R ++ Sbjct: 1281 GASLVIIDDQRDVFSLKETAEKERITIWNSVPAIMGMTA--DVYPDNELNH-HLRLILLS 1337 Query: 2764 GEAFDPFYAKKFFSRLAEDVEVYNVYGPTETTVACTFYRYYPDKDLRNPVPIGGPIFNVQ 2823 G+ + P + ++ EV ++ G TE ++ +Y ++ +P G P+ N + Sbjct: 1338 GD-WIPLQLPATIKKTFKNAEVISLGGATEGSIWSIYYPIQKVEEDWKSIPYGKPLANQK 1396 Query: 2824 LYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREELTREKFVPDPFQTSGMMYRTGDLVR 2883 +YV++QN +L +G+ GEL I G GV+ GY++ +E T F+ Q G +Y+TGD Sbjct: 1397 IYVLNQNKQLCPVGVEGELYIGGAGVASGYIHDQEKTEHSFI--QHQELGYIYKTGDYGV 1454 Query: 2884 MLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCAYY 2943 + +DG VEFLGR D QVKIRG+R+E+GEIEN LV + KA+VI T P + L A+ Sbjct: 1455 LKEDGYVEFLGRKDSQVKIRGYRVEMGEIENTLVSHQEITKASVIDYTSPDGIKNLYAFV 1514 Query: 2944 TADFPMNXXXXXXXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKLPDSFESFQMEDAY 3003 A+ ++ P +M+P+ FVQ++ IPLT +GKVD++ L D E ++ Sbjct: 1515 VAENAISQLDVKEFLQKTLPDYMIPAKFVQIEEIPLTVNGKVDKRTLHDLAEQHTADEGQ 1574 Query: 3004 SA----PQNFIEEKLALVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRL-KKYGLSLE 3058 P+N + L +W+++ G++ + S+ ++GGDS+KAI I++ + K+ + + Sbjct: 1575 RGGRMLPENETQAMLLEIWKDIFGLDSINLDVSYYEIGGDSLKAISIITEINKRMNVEMP 1634 Query: 3059 VKELFLHQNIKGISPFVKQNIKRHNQGTIEGPVKLTAIQKWFFEQNFAEMHHWNQSILLH 3118 + E+F + I + + +K + +E P++ A +K ++ + A+ + S +L Sbjct: 1635 ISEIFKNDTIIALDHY----LKNREESDMEHPIQ-KAREKEYYPTSPAQQRMYMLS-MLE 1688 Query: 3119 NE--------------RFDVQFIRQAFQRITEHHDALRMVYRHTGQAGVEQSNRGLAGEL 3164 NE R + + A + + H+ LR G E N L ++ Sbjct: 1689 NERGAYHIPMALLVEGRINAMQLENALKTFLQRHEILR--------TGFEIQNNELIQKI 1740 Query: 3165 F-------SLEVTDLTGCDDHTDLMHAGIKTIQKGI---DLEKGPLLKLGLYQTTNGDYL 3214 + E D + D H LM + ++ I DL + PL++ L + + ++ Sbjct: 1741 YENVDFRLEYECLDASITDQHA-LMEITSRYCKESIKPFDLSRPPLMRAKLIKIDDIRHI 1799 Query: 3215 AIV-IHHLVVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALEVYANSPKL 3273 ++ HH++ DGVS I++++ Y ++ L E + Y+ + E + S + Sbjct: 1800 LVINFHHIISDGVSQGILMNEILELYSNVP------LPEVNVQYKDYVEWNHTFNQSAAM 1853 Query: 3274 LQELAYWTDVNRIAVPA---LPKDSEAGNGKIKDRYQTKTVL--SEKETTNLLRHAGDAY 3328 ++ AYW DV R +P+ P D + + D ++ +V E+E ++ +R Sbjct: 1854 KKQEAYWLDVYR-DIPSKLDFPYDYKRHH---IDTFEGSSVFLEMERELSDHIRKLAKHN 1909 Query: 3329 QTETXXXXXXXXXXXIKGWANVDRVRINMEGHGREALIQDLDITRTVGWFTSTYPLVLEL 3388 T + + N + + GR D+ G F +T L E+ Sbjct: 1910 GTTLYTVMLSAYYVLLNKYTNQTDIVVGTAAAGR----LHPDLQDVFGVFVNTLALRNEV 1965 Query: 3389 ANSHELPLHIMTTKE 3403 S+ + TKE Sbjct: 1966 DTSYSFKEFLQQTKE 1980 Score = 448 bits (1152), Expect = e-123, Method: Compositional matrix adjust. Identities = 295/928 (31%), Positives = 475/928 (51%), Gaps = 53/928 (5%) Query: 2484 EETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMA 2543 E LI FN+T T YP KT+++LFEEQA +TP ALV + +TY N K NQ A Sbjct: 17 ENEKELILHFNNTKTDYPKNKTLHELFEEQAMKTPDHTALVFGAQRMTYRELNEKANQTA 76 Query: 2544 RMLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLE 2603 R+LR KG+ + I+ + SFE+II + ++KAGGAY+PIDP P +RI F++ D+ Sbjct: 77 RLLREKGIGRGSIAAIIADRSFEMIIGIIGILKAGGAYLPIDPETPKDRIAFMLSDTKAA 136 Query: 2604 IMLTHKGLAEKCQFQGEFI--DAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKG 2661 ++LT A+ + + + D +S + + + SVN D AYIIYTSGSTG PKG Sbjct: 137 VLLTQGKAADGIDCEADIVQLDREASDGFSKEPLS--SVNDSGDTAYIIYTSGSTGTPKG 194 Query: 2662 VMTRHQGLTNYVWWGDKTYVHGEAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSGVSY 2721 V+T H + V + + + V L S+ +FD SV I+ L++G + + + Sbjct: 195 VITPHYSVIRVVQNTNYIDITEDNVILQL-SNYSFDGSVFDIFGALLNGASLVM---IEK 250 Query: 2722 ESLLE-----AVVIDNQVDFIMLTPSHLKILGEYDLSRL-KIRKFIIGGEAFDPFYAKKF 2775 E+LL + + + +V + +T + ++ + + L +RK + GGE + +K Sbjct: 251 EALLNINRLGSAINEEKVSVMFITTALFNMIADIHVDCLSNLRKILFGGERASIPHVRKV 310 Query: 2776 FSRLAEDVEVYNVYGPTETTVACTFYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNGKLQG 2835 + + D ++ +VYGPTE+TV T+Y D +PIG P+ N + ++D+ GKL Sbjct: 311 LNHVGRD-KLIHVYGPTESTVYATYYFINEIDDEAETIPIGSPLANTSVLIMDEAGKLVP 369 Query: 2836 IGIPGELCIAGDGVSRGYLNREELTREKFVPDPFQTSGMMYRTGDLVRMLQDGNVEFLGR 2895 IG+PGELCIAGDG+S+GYLNREELT EKF+P PF +Y+TGDL + L DGN+EF+GR Sbjct: 370 IGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERLYKTGDLAKWLPDGNIEFIGR 429 Query: 2896 MDDQVKIRGHRIELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTADFPMNXXXXX 2955 +D QVKIRG RIELGEIE++L +N+ V + Y+CAY TA+ ++ Sbjct: 430 IDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDEESRPYICAYITANREISLDELK 489 Query: 2956 XXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIEEKLA 3015 P +M+P++FV++ +PLT +GKVDRK LP+ + E+ Y AP+N EEKLA Sbjct: 490 GFLGEKLPEYMIPAYFVKLDKLPLTKNGKVDRKALPEPDRTAGAENEYEAPRNETEEKLA 549 Query: 3016 LVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRLK-KYGLSLEVKELFLHQNIKGISPF 3074 VW++VL + K G + F ++GG S+ A+++++++K K + + + +LF IK +S F Sbjct: 550 AVWQDVLHVEKAGIHDHFAQMGGHSLHAMELIAKIKEKMNVEIPLHQLFKLATIKELSAF 609 Query: 3075 VKQNIKRHNQGT----------IEGPVKLTAIQKWFF---EQNFAEMHHWNQSILLHNER 3121 ++ N + T I LT IQ + ++ F + Sbjct: 610 IEANHQEDKGDTLVTRAADPENIHEIFPLTGIQLAYLVGRDETFEIGGVATNLTVEFEAD 669 Query: 3122 FDVQFIRQAFQRITEHHDALR-MVYRHTGQAGVEQSNRGLAGELFSLEVTDLTGCDD--- 3177 D+ + Q++ + H LR +V+ + Q +E + R +++E DL G + Sbjct: 670 VDLNRFQLTLQKLIDRHPILRTIVFENGTQKILEATQR------YTIETQDLRGFTEEEI 723 Query: 3178 HTDLMHAGIKTIQKGIDLEKGPLLKLGLYQTT-NGDYLAIVIHHLVVDGVSWRIILDDFA 3236 + ++ K K ID PL +L + Y + + L+ D S + ++ +F Sbjct: 724 NVRILEQREKMTSKIIDPSVWPLFELKTFMLPGEKKYFFLNVDPLICDDSSMKRLIREFK 783 Query: 3237 SCYLSLDNGEEAGLIEKS--DSYQKWAEALEVYANSPKLLQELAYWTDV--NRIAVPALP 3292 Y E GL S S++ + A + + + ++ YW D + + P LP Sbjct: 784 QLY------ENPGLQLPSLEYSFRDYVLASINFKQTSRYQKDQQYWLDKLDHFPSAPELP 837 Query: 3293 KDSEAGNGKIKDRYQTKTVLSEKETTNLLRHAGDAYQTETXXXXXXXXXXXIKGWANVDR 3352 S+ + K ++ + + T N L+ + + W+ + Sbjct: 838 LKSDPAHVA-KPSFKKFSTFLDGHTWNELKKKARHHHLTPTSVLCAAYAYILAYWSRQNH 896 Query: 3353 VRINMEGHGREALIQDLDITRTVGWFTS 3380 IN+ R D+ +G FTS Sbjct: 897 FAINLTVFNRIPF--HPDVKNMIGDFTS 922 Score = 141 bits (356), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 104/423 (24%), Positives = 190/423 (44%), Gaps = 22/423 (5%) Query: 1338 QQQISLVIHSNDTHGVVHHETVGLYLRGELNKAALETAYHKVLNRHESLRSTISADGNEQ 1397 QQ++ ++ + G +H + L + G +N LE A L RHE LR+ NE Sbjct: 1678 QQRMYMLSMLENERGA-YHIPMALLVEGRINAMQLENALKTFLQRHEILRTGFEIQNNEL 1736 Query: 1398 IVASHANADIFFADILADYSALGDEA---INQALLKENAAAFDSVMGPLIRLRVLATARH 1454 I + N D D S A I KE+ FD PL+R +++ Sbjct: 1737 IQKIYENVDFRLEYECLDASITDQHALMEITSRYCKESIKPFDLSRPPLMRAKLIKIDDI 1796 Query: 1455 EYLLALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTP---TPFSDYAIWQKRML 1511 ++L ++ HHII+DG S + + E+ LYS +P P + DY W Sbjct: 1797 RHILVINFHHIISDGVSQGILMNEILELYSN--------VPLPEVNVQYKDYVEWNHTFN 1848 Query: 1512 ESQPKEKAAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQS 1571 +S +K AYW + + + P R +GS ++ L+ ++ +++ Sbjct: 1849 QSAAMKKQEAYWLDVYRDIPSKLDFPYDYKRHHIDTFEGSSVFLEMERELSDHIRKLAKH 1908 Query: 1572 MKVSLFTVLLSAYKVLLYRISNHKELVVGIPTAGQMQMGQKHLVGYCLNILPFSTTINPE 1631 +L+TV+LSAY VLL + +N ++VVG AG++ + + G +N L ++ Sbjct: 1909 NGTTLYTVMLSAYYVLLNKYTNQTDIVVGTAAAGRLHPDLQDVFGVFVNTLALRNEVDTS 1968 Query: 1632 MTFRXXXXXXXXXXXXXXXXQDYSYASLMKELHSLDGSVHPPQINTMFNMDKSLETPDFT 1691 +F+ +Y + L+++L+ + S P +TMF ++ + FT Sbjct: 1969 YSFKEFLQQTKERTIAAFDNSEYPFDDLIRKLNGVRESNRNPLFDTMFVLEDARM---FT 2025 Query: 1692 GMDVELLQSPVSY----SKYDLSMNIVELDHELMIDFEYDPNLFDTQIITGWANYFNRIL 1747 ++ SP+ + +K+D+ N+++ + +++++ EY +LF + I A + RIL Sbjct: 2026 KQKGDVKLSPIIFELDNAKFDMIFNVLDFEQKIVLNIEYSTSLFKDETIQKIAEDYFRIL 2085 Query: 1748 LAV 1750 V Sbjct: 2086 EEV 2088 Score = 135 bits (340), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 100/397 (25%), Positives = 172/397 (43%), Gaps = 14/397 (3%) Query: 1340 QISLVIHSNDTHGVVHHETVGLYLRGELNKAALETAYHKVLNRHESLRST-ISADGNEQI 1398 Q L I S V ++ + L G+ + E ++ RHES R++ + DG Sbjct: 2712 QKRLYILSQTGSHVAYNMPFAMTLEGDFDIRRFENTLKNMVKRHESFRTSFVMIDGE--- 2768 Query: 1399 VASHANADIFFADILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLL 1458 V +I D YS +G E+ + + K F PL+R V+ E+LL Sbjct: 2769 VMQQIEKEI---DFQVAYSDIGKESAEEKI-KSFIRPFHLEKAPLLRAEVVKLNEREHLL 2824 Query: 1459 ALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQPKEK 1518 HHII+DG S +F+QEL ALY +SL P + DYA W+ S+ ++ Sbjct: 2825 MFDMHHIISDGVSTDIFIQELGALYEG-----KSLKPFHIQYKDYAEWENSHARSEELKR 2879 Query: 1519 AAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVSLFT 1578 YW + P +LP R +G ++ KL+ +++ V+++ Sbjct: 2880 QEEYWLKTYKGDIPVLDLPIDHKRPLTKSSEGDTVTAAIESETFRKLQHMAKENGVTMYM 2939 Query: 1579 VLLSAYKVLLYRISNHKELVVGIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRXXX 1638 +LL+ Y LL + + ++++VG P AG+ +HL+G +N L + TFR Sbjct: 2940 LLLAGYTALLSKYTGQEDIIVGTPAAGRNHEDIQHLIGMFVNTLAIRNHPEGKKTFRDYL 2999 Query: 1639 XXXXXXXXXXXXXQDYSYASLMKELHSLDGSVHPPQINTMFNMDKSLETP-DFTGMDVEL 1697 QDY + L+++++ P +TM + P + G+ L Sbjct: 3000 QEVKENTLQAYENQDYPFEELVEKVNIKRDMARNPLFDTMLVYHNTDVKPFEAEGLRSRL 3059 Query: 1698 LQSPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQ 1734 ++ SK+D+++ E L ++ EY LF+ + Sbjct: 3060 VEIKRGISKFDITVTASEAADGLRLEVEYSTTLFNKE 3096 Score = 119 bits (298), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 117/465 (25%), Positives = 223/465 (47%), Gaps = 45/465 (9%) Query: 3559 YTMTPMQESM-LFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRFV 3617 Y +P Q+ M + L+N+R AYH L ++G I L + K + +++ILRT F Sbjct: 1672 YPTSPAQQRMYMLSMLENERG-AYHIPMALLVEGRINAMQLENALKTFLQRHEILRTGFE 1730 Query: 3618 YKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDRE--KRFDLVQGPLMRA 3675 + + +Q + + DF LE+E + +++ A ME +E K FDL + PLMRA Sbjct: 1731 IQN-NELIQKIYENVDFRLEYECLD-ASITDQHALMEITSRYCKESIKPFDLSRPPLMRA 1788 Query: 3676 ILLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSLETH-QYRLYLDW 3734 L+K D + ++ +FHHI+ DG GI++ ++LE Y + P E + QY+ Y++W Sbjct: 1789 KLIKIDDIRHILVINFHHIISDGVSQGILMNEILELYSNV-----PLPEVNVQYKDYVEW 1843 Query: 3735 LASKNKEEA----KVYW----------MQYLEDYKYKELLRKEGTSKEFRLAVLDIKLEE 3780 + N+ A + YW + + DYK + EG+S + +++E Sbjct: 1844 NHTFNQSAAMKKQEAYWLDVYRDIPSKLDFPYDYKRHHIDTFEGSS-------VFLEMER 1896 Query: 3781 KVRTAVTHVASSSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGR-SPEIEGIERMVG 3839 ++ + +A +G T+ + + + +LL+KY N D+V G +GR P+++ + G Sbjct: 1897 ELSDHIRKLAKHNGTTLYTVMLSAYYVLLNKYTNQTDIVVGTAAAGRLHPDLQDV---FG 1953 Query: 3840 LFINTIPVRVRL-SGKTFHELAGEIQSSFISSEQYGYVPLSD-IQAWSHRDLINHVMVFE 3897 +F+NT+ +R + + +F E + + I++ P D I+ + N +F+ Sbjct: 1954 VFVNTLALRNEVDTSYSFKEFLQQTKERTIAAFDNSEYPFDDLIRKLNGVRESNRNPLFD 2013 Query: 3898 NYPLDREIRDTDGQQMEYGFQIAGCEILEHTNYDFSII---IEPGEDFIIRIVYNALAYD 3954 + + R Q+ + I E N F +I ++ + ++ I Y+ + Sbjct: 2014 TMFVLEDARMFTKQKGDVKLSPI---IFELDNAKFDMIFNVLDFEQKIVLNIEYSTSLFK 2070 Query: 3955 KETISILESYLLAIIGQVTACPQIEAGDVEVLSQEEKLKLMNVFN 3999 ETI + I+ +V+ + ++++S++EK L+ FN Sbjct: 2071 DETIQKIAEDYFRILEEVSENLDVALHQIDMISRQEKRTLLESFN 2115 Score = 114 bits (285), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 100/411 (24%), Positives = 177/411 (43%), Gaps = 25/411 (6%) Query: 1340 QISLVIHS--NDTHGVVHHETVGLYLRGELNKAALETAYHKVLNRHESLRST----ISAD 1393 Q ++ H+ + T G + V + L+G ++ LE ++H+++ RHE LR++ I+A+ Sbjct: 4216 QKGMLFHNAMDQTSGAYFQQIV-IKLKGRVHPDILEESFHEIVKRHEILRASFEYEITAE 4274 Query: 1394 GNEQIVASHANADIFFADILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATAR 1453 QI+A D+ + I L ++ FD L+R+ ++ + Sbjct: 4275 PR-QIIARDRKTPFTSIDLTGENRTRQHRFIETYLKEDQEKGFDLSSEALMRVCLIKMSD 4333 Query: 1454 HEYLLALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLES 1513 Y L S HHI+ DGW L + L EL +LY G L P P+ DY W LE Sbjct: 4334 ESYRLIWSHHHILLDGWCLGIVLSELFSLYGKIMKGESRRLKEPKPYGDYIKW----LEK 4389 Query: 1514 QPKEKAAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMK 1573 Q +E+A AYWK+ ELP+F + G LT K+ +++ Sbjct: 4390 QDQEEAVAYWKDYLKGYESRSELPAFNRGATSEEYCGKEKVISFSKELTTKITRIAKQHH 4449 Query: 1574 VSLFTVLLSAYKVLLYRISNHKELVVGIPTAGQMQM--GQKHLVGYCLNILPFSTTINPE 1631 V++ TVL + ++L + N E+V G +G+ G + +VG ++ +P + Sbjct: 4450 VTINTVLQGIWGMILAKYKNTDEVVFGTVVSGREAPVDGIEEMVGLFIHTIPTRISFEGA 4509 Query: 1632 MTFRXXXXXXXXXXXXXXXXQDYSYASLMKELHSLDGSVHPPQINTMFNMDKSLETPDF- 1690 +F+ YSY +L E+ L + M + + + F Sbjct: 4510 RSFKEVLKKTQAESIESNR---YSYMNL-SEIQVLSEMKRELITHVMAFQNYAFDEELFR 4565 Query: 1691 -----TGMDVELLQSPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQII 1736 TG ++E + + Y+ ++ V D +L + ++ N++D II Sbjct: 4566 SQSGETGFELEGVHGK-ERTNYNFNLTGVLEDEQLKLKLTFNENVYDNTII 4615 Score = 112 bits (281), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 83/257 (32%), Positives = 122/257 (47%), Gaps = 23/257 (8%) Query: 1800 VILDKDMHPSPVGVPGEVYLA-------RLTEPSLLAEQ-------PST---STGIMAMY 1842 +I+D+ P+GVPGE+ +A L L AE+ P TG +A + Sbjct: 4986 LIMDEAGKLLPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERLYKTGDLAKW 5045 Query: 1843 TADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAY 1902 D I+ IG + G I L I+ +L +H I VTV+ + I AY Sbjct: 5046 LPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDE--ESRPYICAY 5103 Query: 1903 ITP-RGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKAL 1961 IT R S+ E+K FL ++P IP+ F+ +D++PL G ++ + LP D Sbjct: 5104 ITANREISLD---ELKGFLGEKLPDYMIPAYFVKMDKLPLTKNGKVDRKALPEPDRSAGT 5160 Query: 1962 REEIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDIS 2021 E P N E+R+ I +VL E + + FF+ GGNSLKA SI K F D+ Sbjct: 5161 EAEYEAPRNYVEQRIISILEDVLGTERMGISCHFFDKGGNSLKAMQAVHSINKTFGIDMR 5220 Query: 2022 LRMLFEHPTVKGLAKAI 2038 + F+HPT K LA+ + Sbjct: 5221 ISTFFKHPTAKSLARFV 5237 Score = 107 bits (266), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 103/441 (23%), Positives = 205/441 (46%), Gaps = 42/441 (9%) Query: 3580 AYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRFVYKKLHRPLQIVLGSSDFHLEFE 3639 AY+ + L+GD + K +V +++ RT FV +Q + DF + + Sbjct: 2726 AYNMPFAMTLEGDFDIRRFENTLKNMVKRHESFRTSFVMID-GEVMQQIEKEIDFQVAYS 2784 Query: 3640 DITHMESSEKMAHMERLKALDREKRFDLVQGPLMRAILLKTGDSVYQMLWSFHHILMDGW 3699 DI ES+E E++K+ R F L + PL+RA ++K + + +++ HHI+ DG Sbjct: 2785 DIGK-ESAE-----EKIKSFIRP--FHLEKAPLLRAEVVKLNEREHLLMFDMHHIISDGV 2836 Query: 3700 CIGIVLKDMLEHYKQLNAGSRPSLETHQYRLYLDWLASKNKEE----AKVYWMQ-YLEDY 3754 I ++++ Y+ G QY+ Y +W S + E + YW++ Y D Sbjct: 2837 STDIFIQELGALYE----GKSLKPFHIQYKDYAEWENSHARSEELKRQEEYWLKTYKGDI 2892 Query: 3755 KYKELL--RKEGTSKEFRLAVLDIKLEEKVRTAVTHVASSSGITINSFFQAVWGILLSKY 3812 +L K +K + +E + + H+A +G+T+ A + LLSKY Sbjct: 2893 PVLDLPIDHKRPLTKSSEGDTVTAAIESETFRKLQHMAKENGVTMYMLLLAGYTALLSKY 2952 Query: 3813 DNAEDVVFGAVISGRSPEIEGIERMVGLFINTIPVRVRLSGK-TFHELAGEIQSSFISSE 3871 ED++ G +GR+ E I+ ++G+F+NT+ +R GK TF + E++ + + + Sbjct: 2953 TGQEDIIVGTPAAGRNHE--DIQHLIGMFVNTLAIRNHPEGKKTFRDYLQEVKENTLQAY 3010 Query: 3872 QYGYVPLSDI-------QAWSHRDLINHVMVFENYPLDREIRDTDGQQMEY-GFQIAGCE 3923 + P ++ + + L + ++V+ N TD + E G + E Sbjct: 3011 ENQDYPFEELVEKVNIKRDMARNPLFDTMLVYHN---------TDVKPFEAEGLRSRLVE 3061 Query: 3924 ILEH-TNYDFSIIIEPGEDFI-IRIVYNALAYDKETISILESYLLAIIGQVTACPQIEAG 3981 I + +D ++ D + + + Y+ ++KE + L +L++++ Q P I Sbjct: 3062 IKRGISKFDITVTASEAADGLRLEVEYSTTLFNKERMERLSEHLISLLEQAADHPDIAIN 3121 Query: 3982 DVEVLSQEEKLKLMNVFNKPN 4002 ++VL++ E+ +++ FN+ + Sbjct: 3122 QIDVLTKGERHRVLYDFNRTD 3142 >ref|ZP_00177151.1| hypothetical protein Cwat285401 [Crocosphaera watsonii WH 8501] Length = 6281 Score = 1336 bits (3458), Expect = 0.0, Method: Compositional matrix adjust. Identities = 774/2139 (36%), Positives = 1201/2139 (56%), Gaps = 66/2139 (3%) Query: 1913 VREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALREEIMLPENET 1972 + ++ +FLLS++P +PSAF+ L+ +PL G IN + LP E + L EEI+LP Sbjct: 1861 ISQLPEFLLSKLPNYMVPSAFVTLEALPLTPNGKINRKALPDPLETQILSEEIVLPSTPI 1920 Query: 1973 EERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDISLRMLFEHPTVK 2032 EE LA+IW +L +E V N++FFELGG+SL A+ + I++ F+ ++ LR LFE PT+ Sbjct: 1921 EELLADIWTEILGIETVGVNNNFFELGGHSLIATRVVSQIRQVFNVELPLRSLFEKPTIA 1980 Query: 2033 GLAK----AINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGGAGTAYNITGILHV 2088 LAK IN + I + + P S +Q+RL+ + ++ YNI+G + + Sbjct: 1981 ELAKEIEKVINSDVEVEFVSIERVSRNRELPLSFAQQRLWFLAELEPDSPFYNISGAVKL 2040 Query: 2089 EGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSISY--------SIAE 2140 +G+L+ +E++F +V+RHE LRT+F+ + V VI + P ++S S E Sbjct: 2041 QGQLNVEALEQSFNEIVRRHENLRTNFQTRDGQAVAVISPERPLNLSTVDISSLNGSTQE 2100 Query: 2141 DEDEPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGISANILCNDLIS 2200 ++ E+ K PF +++ L R+ ++ + E+IV++ MHHII+DG S + +L + Sbjct: 2101 EKVRQEITKEAEKPFDISKDLLLRIKLLHLGEEENIVLVTMHHIISDGWSMGVFIKELGT 2160 Query: 2201 LYSG------ENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDDIPSLTLPLDF 2254 LY+ +L L +QY D+ A E L E + Q YW + L + L LP + Sbjct: 2161 LYTNFCNQEPISLQELPIQYVDFAAWQREWLQGEVLENQVSYWLKQLENTPKLLELPTNK 2220 Query: 2255 PRPPVQSFDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYSNQEDIVIG 2314 PRP +Q+F+GA +S L +L+ L LS + +TL+ LLA + LL +Y+ QED+V+G Sbjct: 2221 PRPAIQTFNGATHSFELSKELSLALNKLSQQKGSTLFMTLLAGFQTLLWRYTAQEDVVVG 2280 Query: 2315 SPVAGRFNYSTNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELI 2374 SP+A R ++G FVNTL +R A++ +F E L +V+E TL A+ +QD PFE L+ Sbjct: 2281 SPIANRNRGEIEGLIGFFVNTLVLRTNLAENPSFSELLEQVREVTLGAYSHQDVPFELLV 2340 Query: 2375 SKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKFDLILEVIENT 2434 +L ERD+S +P+F VMFVLQ+ ++ + L + L E K+ AKFDL L + E Sbjct: 2341 ERLQPERDLSHSPLFQVMFVLQNAPMSA--LELPGVTLTSLENKHQTAKFDLSLYMTETE 2398 Query: 2435 ENLTLNFEYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFN 2494 L NFEY LF+E TI RM R+L+ +V N LSD+ LL + E +L++ +N Sbjct: 2399 SGLVGNFEYNTDLFEEKTITRMVGHLERLLSAIVANPQQPLSDLPLLSEPERHQLLWEWN 2458 Query: 2495 DTATAYPGGKTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPD 2554 T YP + ++QLFE Q +TP AVA+ +G+ +TY+ N+K NQ+A LRS GVKP+ Sbjct: 2459 QTKVEYPQNQCIHQLFEAQVEKTPEAVAVEFEGQKLTYQELNKKANQVAHYLRSLGVKPE 2518 Query: 2555 TTVGILMEHSFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEK 2614 VGI +E S E++I + ++KAGGAYVP++PTYP+ERI ++++DS + I+LT L Sbjct: 2519 VLVGIYIERSLEMVIGLLGILKAGGAYVPLEPTYPTERIQYLLEDSKVAILLTRNHLITT 2578 Query: 2615 C-QFQGEFI--DAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTN 2671 ++QG I D NPVS S D+L YIIYTSGSTG PKG M HQG+ N Sbjct: 2579 LPEYQGRIISLDTDPELMTIERKDNPVSGLSRDNLIYIIYTSGSTGKPKGTMNTHQGVVN 2638 Query: 2672 YVWWGDKTYVHGEAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSGVSYE--SLLEAVV 2729 + W ++TY + +FD+S + PL++G + + ++ S L ++ Sbjct: 2639 RLLWMEETYQLTSRDKVLQKTPFSFDVSGWEFWWPLMTGACLVVAQTEGHKDPSYLIKLI 2698 Query: 2730 IDNQVDFIMLTPSHLKILGEY--DLSRLKIRKFIIGGEAFDPFYAKKFFSRLAEDVEVYN 2787 + Q+ + PS L+I E + S +RK GEA +KF S L E++N Sbjct: 2699 KEKQITILHFVPSMLQIFLEEADEESCSSLRKVFCSGEALTVALQEKFLSIL--KAELHN 2756 Query: 2788 VYGPTETTVACTFYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGD 2847 +YGPTE + TF++ D L + VPIG P+ N Q Y++D N + +G+PGEL + G Sbjct: 2757 LYGPTEAAIDVTFWQCQVDSKLSS-VPIGRPVANTQTYILDANLQPVPVGVPGELYLGGV 2815 Query: 2848 GVSRGYLNREELTREKFVPDPFQ---TSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRG 2904 ++RGYLNR ELT E+F+ +PF +S +Y+TGDLVR L DGN+E+LGR+D+QVKIRG Sbjct: 2816 QLARGYLNRPELTAERFIENPFSEDFSSPRLYKTGDLVRYLADGNIEYLGRIDNQVKIRG 2875 Query: 2905 HRIELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCAYYT--ADFPMNXXXXXXXXXXXX 2962 RIELGEIE L P V + VI ++ L AY + + Sbjct: 2876 FRIELGEIETLLASHPEVLETVVIPKEETPGNKRLVAYLVIRPEITIKIEEIRQFLKAKL 2935 Query: 2963 PRHMVPSFFVQMKSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIEEKLALVWEEVL 3022 P +M+PS FV ++++PLT +GKVDRK L +S E Y AP+ IEE L +W+EVL Sbjct: 2936 PNYMIPSAFVTLEALPLTPNGKVDRKILLESQEEISRSKEYVAPETEIEETLVKIWQEVL 2995 Query: 3023 GINKVGTSNSFIKLGGDSIKAIQIVSRLKKYGLSLEVKELFLHQNIKGISPFVKQNIKR- 3081 + KVG ++F ++GGDSI +I++VSR K GL + K++F +Q I ++ K + Sbjct: 2996 LLEKVGIHDNFFEIGGDSILSIKVVSRAKNAGLQIRSKQIFENQTIAELALVAKIKTETI 3055 Query: 3082 HNQGTIEGPVKLTAIQKWFFEQNFAEMHHWNQSILLH-NERFDVQFIRQAFQRITEHHDA 3140 QG + G LT IQKWF ++N E HH+NQS++L + + + ++ Q++ EHHDA Sbjct: 3056 AEQGIVTGIAPLTPIQKWFLDKNPKEAHHFNQSVILEIPGEIEAEIVEKSVQKLLEHHDA 3115 Query: 3141 LRMVY-RHTGQAGVEQSNRGLAGELFSLEVTDLTGC-DDHTDLMHAGIKT-IQKGIDLEK 3197 LR+ + R T + +Q N GL G L + DL+ ++ A I T Q ++L Sbjct: 3116 LRLRFNRETLED--KQINEGL-GVTNLLTIVDLSSTPKEYQGERIAEIATEFQGSLNLRN 3172 Query: 3198 GPLLKLGLYQTTNGD--YLAIVIHHLVVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSD 3255 GPL+++ L+ D L I+IHHLVVDGVSWRI+L D L E A L EK+ Sbjct: 3173 GPLMQVVLFNLGEADNNRLLIIIHHLVVDGVSWRILLSDLEEISQKLTAQEPAKLREKTI 3232 Query: 3256 SYQKWAEALEVYANSPKLLQELAYWTDVNRIAVPALPKDSEAGNGK--IKDRYQTKTVLS 3313 ++ KWAE L YA + ++ EL YW N +P D E + + D Q LS Sbjct: 3233 AFIKWAEELNKYAQTEEVEAELDYWLYKNWTKTGVIPLDCEEKEPENLVGDVVQVSRKLS 3292 Query: 3314 EKETTNLLRHAGDAYQTETXXXXXXXXXXXIKGWANVDRVRINMEGHGREALIQDLDITR 3373 + T LL +AY T+ + W N V IN+EGHGRE L +++D++R Sbjct: 3293 VEATRKLLGEVNEAYNTQINDILLSALKIVLGEWTNSSSVIINLEGHGREELFEEVDLSR 3352 Query: 3374 TVGWFTSTYPLVLELANSHELPLHIMTTKETIRQTPNKGMGYQVLKYLT-SPELRAAVDF 3432 TVGWFTS +P++LE ++ I + KE +R+ PN+GMGY +L+YL+ SP+++ + Sbjct: 3353 TVGWFTSLFPVLLETPEQIQIGEIIKSIKEQLREIPNRGMGYGILRYLSESPDIKEKIAA 3412 Query: 3433 NVMPEISFNYLGQFGNEASYGTFEICNTFMESTESPESHRPYAIDINAMIVGNRVEIRVD 3492 EISFNYLGQF ++ +S + +R + +DIN++I+ +++I Sbjct: 3413 IPQGEISFNYLGQFDQVGEETGWKFAKEPKGVNQSLKQNRDHILDINSLIIEGKLQIEWT 3472 Query: 3493 YNPGQFNEATMSRFAELLLNSLKLIISHCTREERIQRSPSDLTYKKLTFEELDD-LNRLY 3551 YN ++ T+ + A+ L +L+ II HC +EE +PSD +L ++D+ L Sbjct: 3473 YNKNLHSQETIEKLAKKYLKTLENIIEHCQQEETFGYTPSDFPSAQLNQLQIDELLAGFK 3532 Query: 3552 PGGITDVYTMTPMQESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDI 3611 I+ VY ++PMQE MLFH + S Y +Q L L G+I +++ +V ++ + Sbjct: 3533 TKNISSVYPLSPMQEGMLFHTISEPESGVYFQQIALGLTGNIELLAFESAWQKVVDRHSV 3592 Query: 3612 LRTRFVYKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGP 3671 LRT FV + + +PLQIVL E D + ++ ++ L + R + F L Q P Sbjct: 3593 LRTFFVAEDVEKPLQIVLKQVKLPWENMDWRGLSQQKQQEQLDELLSSQRLEGFQLNQAP 3652 Query: 3672 LMRAILLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSL-ETHQYRL 3730 LM+ IL++ ++ Y+ + S HHILMDGWC+ I+ K++L Y+ G +L Y Sbjct: 3653 LMKCILIELSENNYKFVLSSHHILMDGWCLPIIFKEVLSIYEAEIQGKNFNLPRPRPYED 3712 Query: 3731 YLDWLASKNKEEAKVYWMQYLEDYKYKELLRKEGTSKEFRL-----AVLDIKLEEKVRTA 3785 Y+DWL +NKE A +W + L+ + L E + + +L ++++L ++ Sbjct: 3713 YIDWLKLQNKETASQFWQETLQGFTAPTPLVVEKSQYQTQLNKSNYQEIELRLSPQLSRE 3772 Query: 3786 VTHVASSSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGRSPEIEGIERMVGLFINTI 3845 + ++ +T+++ Q VWG+LLS Y ED+VFG +SGR P + +E+ VGLFINT+ Sbjct: 3773 LQALSQKYHLTLSTIMQGVWGLLLSGYSGEEDIVFGVTVSGRPPSLPEVEKRVGLFINTL 3832 Query: 3846 PVRVRL-SGKTFHELAGEIQSSFISSEQYGYVPLSDIQAWSH----RDLINHVMVFENYP 3900 P+R+++ + EIQ ++ Y Y PL DI+A S L +MVFENYP Sbjct: 3833 PLRIQIPPQQQLIPWLEEIQQLMSQAQDYAYTPLVDIKAVSEVPGGMPLFETIMVFENYP 3892 Query: 3901 LDREIRDTDGQQMEYGFQIAGCEILEHTNYDFSIIIEPGEDFIIRIVYNALAYDKETISI 3960 + R + + +I+ + E TNY +++ PGE +IR+ Y+ + ++ ETI Sbjct: 3893 IGRSLTK------DSALEISKIQSFEQTNYPLTVMAVPGEQLLIRVSYDTVRFESETIER 3946 Query: 3961 LESYLLAIIGQVTACPQIEAGDVEVLSQEEKLKLMNVFN 3999 + +L + + PQ ++ +L++ E+ +L+ +N Sbjct: 3947 MSEHLETMFSAIVKNPQQRVREIPLLTETERHQLLWEWN 3985 Score = 811 bits (2096), Expect = 0.0, Method: Compositional matrix adjust. Identities = 536/1599 (33%), Positives = 844/1599 (52%), Gaps = 97/1599 (6%) Query: 1801 ILDKDMHPSPVGVPGEVY-----LAR--LTEPSL---------LAEQPST--STGIMAMY 1842 ILD+ PVGV GE+ LAR P L +E+ S TG +A Y Sbjct: 4315 ILDQSSQLVPVGVVGELCIGGMGLARGYFERPELNKEKFIYNPFSEEESRIYRTGDLARY 4374 Query: 1843 TADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAY 1902 + EI+ +G + G I L I+ Q+ + + A V + D++++AY Sbjct: 4375 LPNGEIEYLGRIDNQVKIRGFRIELGEIETQIAQYTAVKEAVVIARED--IAGDKRLVAY 4432 Query: 1903 ITPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALR 1962 I P+ E+++FL ++P IPSAF++L+++PL G I+ + LP E + L Sbjct: 4433 IVPQEELAVNPSELREFLGEKLPNYMIPSAFVMLEKLPLTPNGKIDRKALPEPQETEILS 4492 Query: 1963 EEIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDISL 2022 EEI+LP EE LA I +L +E V +++FFELGG+SL A+ + I++ F+ ++ L Sbjct: 4493 EEIVLPSTPIEELLAGILSKILGIETVGVHNNFFELGGHSLIATRVVSQIRQVFNVELPL 4552 Query: 2023 RMLFEHPTVKGLAK----AINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGGAGT 2078 R LFE PT+ LAK IN + I + + P S +Q+RL+ + ++ Sbjct: 4553 RSLFEKPTIAELAKEIEKVINSDVEVEFVSIERVSRNRELPLSFAQQRLWFLAELEPDSP 4612 Query: 2079 AYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSISY-- 2136 YNI+G + ++G+L+ +E++F +V+RHE LRT+F+ + V VI + P ++S Sbjct: 4613 FYNISGAVKLQGQLNVEALEQSFNEIVRRHENLRTNFQTRDGQAVAVISPERPLNLSTVD 4672 Query: 2137 ------SIAEDEDEPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGIS 2190 S E++ E+ K PF +++ L R+ ++ + E+IV++ MHHII+DG S Sbjct: 4673 ISSLNGSTQEEKVRQEITKEAEKPFDISKDLLLRIKLLHLGEEENIVLVTMHHIISDGWS 4732 Query: 2191 ANILCNDLISLYSG------ENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDD 2244 + +L +LY+ +L L +QY D+ A E L E + Q YW + L + Sbjct: 4733 MGVFIKELGTLYTNFCNQEPISLQELPIQYVDFAAWQREWLQGEVLENQVSYWLKQLENT 4792 Query: 2245 IPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSK 2304 L LP + PRP +Q+F+GA +S L +L+ L LS + +TL+ LLA + LL + Sbjct: 4793 PKLLELPTNKPRPAIQTFNGATHSFELSKELSLALNKLSQQKGSTLFMTLLAGFQTLLWR 4852 Query: 2305 YSNQEDIVIGSPVAGRFNYSTNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFE 2364 Y+ QED+V+GSP+A R ++G FVNTL +R A++ +F E L +V+E TL A+ Sbjct: 4853 YTAQEDVVVGSPIANRNRGEIEGLIGFFVNTLVLRTNLAENPSFSELLEQVREVTLGAYS 4912 Query: 2365 NQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKF 2424 +QD PFE L+ +L ERD+S +P+F VMFVLQ+ ++ + L + L E K+ AKF Sbjct: 4913 HQDVPFELLVERLQPERDLSHSPLFQVMFVLQNAPMSA--LELPGVTLTSLENKHQTAKF 4970 Query: 2425 DLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKE 2484 DL L + E L +FEY LF+E TI RM R+L+ +V N LSD+ LL + Sbjct: 4971 DLSLYMTETESGLVGSFEYNTDLFEEETITRMVGHLERLLSAIVANPEQRLSDLPLLSEP 5030 Query: 2485 ETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMAR 2544 E +L+ +N+T Y V+QLFE Q +TP AVA+ + + +TY NRK NQ+A Sbjct: 5031 EQHQLLSEWNETKVEY-SSLCVHQLFEVQVEKTPLAVAVEFEDQKLTYHELNRKANQLAH 5089 Query: 2545 MLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEI 2604 LRS GVKP+ VGI +E S E++I + A++KAGGAY+P+DP YP ERI FI++++ + + Sbjct: 5090 YLRSLGVKPEVLVGICVERSLEMVIGLLAILKAGGAYLPLDPNYPQERIQFILEETQVPV 5149 Query: 2605 MLTHKGLAEKC---QFQGEFIDAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKG 2661 +LT L + Q I+ S N +S + D+LAY IYTSGSTG PKG Sbjct: 5150 LLTQASLMDTMPENTAQLVCIEKNSPDIEQQSQDNLISNLTTDNLAYTIYTSGSTGQPKG 5209 Query: 2662 VMTRHQGLTNYVWWGDKTYVHGEAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSG--V 2719 V H L+N+++ + ++ +FD++ +++PLI G ++ + S V Sbjct: 5210 VQIPHSSLSNFLFSMKEEPGLSSKDTLLAVTTYSFDIAALELFLPLIVGARLIVASQEIV 5269 Query: 2720 SYESLLEAVVIDNQVDFIMLTPSHLKILGEYDLSRLKIRKFIIGGEAFDPFYAKKFFSRL 2779 + + L A + D++ + TP+ K+L + K + GGE A + R Sbjct: 5270 ADGTQLLAKLTDSKTTVMQATPATWKLLIAAGWEGNEQLKVLCGGETLPSQLASELLERC 5329 Query: 2780 AEDVEVYNVYGPTETTVACTFYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNGKLQGIGIP 2839 ++N+YGPTETT+ D L + IG I N QLY++DQ+ +L +G+ Sbjct: 5330 E---SLWNMYGPTETTIWSAVSEIKTDSQL---ISIGNGIANTQLYILDQSSQLVPVGVV 5383 Query: 2840 GELCIAGDGVSRGYLNREELTREKFVPDPF-QTSGMMYRTGDLVRMLQDGNVEFLGRMDD 2898 GELCI G+G++RGY R EL +EKF+ +PF + +YRTGDL R L +G +E+LGR+D+ Sbjct: 5384 GELCIGGEGLARGYFQRRELNKEKFIYNPFSEEESRIYRTGDLARYLPNGEIEYLGRIDN 5443 Query: 2899 QVKIRGHRIELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTA--DFPMNXXXXXX 2956 QVKIRG RIELGEIE Q+ + V +A VI + L AY + +N Sbjct: 5444 QVKIRGFRIELGEIETQIAQYTAVKEAVVIAREDIAGDKRLVAYIVPQEELAVNPSELRE 5503 Query: 2957 XXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIEEKLAL 3016 P +M+PS FV ++ +PLT +GK+DRK LP ++ + P IEE LA Sbjct: 5504 FLGEKLPNYMIPSAFVMLEKLPLTPNGKIDRKALPVPEKTPISSNEIVLPSTPIEELLAG 5563 Query: 3017 VWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRLKK-YGLSLEVKELFLHQNIKGISPFV 3075 +W E+LGI VG N F +LGG S+ A +I+S++++ + + + ++ LF I ++ + Sbjct: 5564 IWTEILGIETVGIHNDFFELGGHSLIATRIMSQIRQVFNVDIPLRNLFEKPTIAELAKEI 5623 Query: 3076 KQ-----------NIKRHNQGTIEGPVKLTAIQKWFFEQNFAEMHHWNQSILLHNE-RFD 3123 ++ +I+R ++ E P+ + WF Q + +N S + E + Sbjct: 5624 EKVINSDVGVEVVSIERVSREQ-ELPLSFAQQRLWFLAQIEPDSPFYNMSSTIEVEGSIN 5682 Query: 3124 VQFIRQAFQRITEHHDALRMVYRHTGQAG------VEQSNRGLAGELFSLEVTDLTGCDD 3177 V + Q+F I H++LR + G+ G EQS + +L +L+V + T Sbjct: 5683 VAVLEQSFNEIIRRHESLRTTF-AMGENGPIQIIAPEQSIKITTIDLHNLDVNEQT---- 5737 Query: 3178 HTDLMHAGIKTIQKGIDLEKGPLLKLGLYQT-TNGDYLAIVIHHLVVDGVSWRIILDDFA 3236 + ++ Q +L G L+++ L Q + L + IHH++ D S +++ + A Sbjct: 5738 -EQVQKLALEEAQTPFNLADGLLIRISLLQLGERKNVLLLNIHHIISDAWSMGVLVKELA 5796 Query: 3237 SCYLSLDNGEEAGLIEKSDSYQKWAEALEVYANSPKLLQELAYWTDVNRIAVPALPKDSE 3296 + Y +L N + L E Y +A + KL ++LAYW R + +P Sbjct: 5797 TFYENLVNDKPVQLPELPIQYADFAVWQRQPLQAEKLDKQLAYW----RQQLSGVPDSFN 5852 Query: 3297 AGNGKIKDRYQT----------KTVLSEKETTNLLRHAG 3325 K + QT T LSEK T+L R G Sbjct: 5853 IPTDKPRPELQTFRGAVSEFSLSTELSEK-VTHLSRQEG 5890 Score = 605 bits (1561), Expect = e-171, Method: Compositional matrix adjust. Identities = 364/1025 (35%), Positives = 561/1025 (54%), Gaps = 51/1025 (4%) Query: 1957 EDKALREEIMLPENETEERLAEIWRNVLNLEL-------VNTNDDFFELGGNSLKASLLA 2009 E K R E++ + + EI+ L L + ++ N LG +S+K Sbjct: 426 ETKLTRRELLELSKQQSQSELEIYLRSLILSILRRTDQDIDLNTPLTNLGLDSIKVFEFK 485 Query: 2010 FSIQKEFSTDISLRMLFEHPTVKGLAKAING-------AGKSFLPEITPLGKKDWYPQSS 2062 I+++ I + F +K L I A ++ +P ++Y S Sbjct: 486 NKIEEDMGVTIPIEDFFAELNIKSLCNQILAQLDTPVEASRAIIPTHR---DGNFYQLSF 542 Query: 2063 SQKRLFAIEQMGGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEP 2122 +QKR++ + ++ YNI+G + ++G L+ +E++F +++RHE LRT+F+ + Sbjct: 543 AQKRIWFLAELEPDNPFYNISGTVRIQGHLNLEVLEQSFNEIIRRHETLRTNFQTRDGKA 602 Query: 2123 VQVIHDDIPF--------SISYSIAEDEDEPELVKRFILPFSLNQAPLFRVHIVSRSDHE 2174 V VI + P S+S S E++ + E + PF ++ PL RV ++ E Sbjct: 603 VAVIASERPIKLSIVDVSSLSGSTQEEKVKQETAEEAEKPFDISNDPLLRVKLLRLEQEE 662 Query: 2175 HIVIMDMHHIIADGISANILCNDLISLYSG------ENLPGLEVQYKDYTALHNEMLSNE 2228 +++++ +HHII+DG S +L +L +LY+ L L +QY D+ A + L E Sbjct: 663 NLILVTLHHIISDGWSIGVLLQELTTLYTNFYNQEPLALQELPIQYVDFAAWQRQWLQGE 722 Query: 2229 RIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLSNRLKT 2288 + Q YW + L + L LP D PR +QS+ G YS L +L+ L LS + T Sbjct: 723 VLENQMSYWLKQLENAPEVLELPADNPRQAIQSYRGKIYSFNLSKELSTSLNELSEQQGT 782 Query: 2289 TLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNYSTNNMVGMFVNTLAMRNQPAKHKTF 2348 TL+ LLA + LL +Y+ QEDIV+GSP+A R ++G FVN+L +R A + +F Sbjct: 783 TLFMTLLAGFQTLLWRYTAQEDIVVGSPIANRNRAEVEGLIGFFVNSLVLRTNLAGNPSF 842 Query: 2349 QEFLLEVKENTLEAFENQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLD 2408 +E L +V+E L A+ +QD PF+ L+ +L ER +S NP+F V+F L L+ + D+ L Sbjct: 843 EELLKQVREVALGAYAHQDVPFDLLVERLQPERQLSHNPLFQVVFAL--LNTPMSDLDLP 900 Query: 2409 DIRLNGYEFKNDVAKFDLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTTVV 2468 D L + +A+ DLIL + E + FEY LF+E TI RM+ +L+ +V Sbjct: 901 DATLTVLRNDSGIARCDLILYMTETESGIAGQFEYNTDLFEEKTISRMAGHIQTLLSAIV 960 Query: 2469 ENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGAVALVHQGE 2528 EN +S+I LL E +L+ +N+T Y K ++QLFEEQ P +A+V + + Sbjct: 961 ENPQQKVSEIPLLRATERHQLLVEWNETELEYSQNKCIHQLFEEQVKTKPNGIAVVFEEQ 1020 Query: 2529 SITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGAYVPIDPTY 2588 +TYE N+K NQ+A L GVKPD+ VGI +E S E+II + ++KAGGAY+PIDP Y Sbjct: 1021 QLTYEELNKKANQLAHYLIKLGVKPDSLVGICVERSLEMIIGVLGILKAGGAYLPIDPDY 1080 Query: 2589 PSERINFIIKDSNLEIMLTHKGLAEKCQFQGEFIDAASSKWYCGDDSNPVSVN---SPDD 2645 P ERI +++ DS + I+LT + L EK I + + W + +++N + ++ Sbjct: 1081 PQERIEYMLTDSEVNILLTQERLVEKLPENNSQIISLDTDWSQIATKSDINLNQEINAEN 1140 Query: 2646 LAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYVHGEAVDFPLYSSIAFDLSVTLIYI 2705 LAY+IYTSGSTG PKGVM HQG+ N + + + ++S +FD I + Sbjct: 1141 LAYVIYTSGSTGKPKGVMIEHQGVCNLAQVQRERFKVNSSSRIFQFASFSFDACAWEIVM 1200 Query: 2706 PLISGNKVFIY---SGVSYESLLEAVVIDNQVDFIMLTPSHLKILGEYDLSRLKIRKFII 2762 L+SG ++ I + E+ LE + + + I L PS L ++ +L+++K I+ Sbjct: 1201 ALLSGARLVITDKDKKLPGEN-LEKTLNEYGITHITLPPSALTVMSPENLTQVK--TIIL 1257 Query: 2763 GGEAFDPFYAKKFFSRLAEDVEVYNVYGPTETTVACTFYRYYPDKDLRNPVPIGGPIFNV 2822 GEA A + E +++N YGPTE TV T Y D + +PIG PI N Sbjct: 1258 AGEACPGTLAALW----QEGRDLFNGYGPTEDTVCATIGEYQQDLE---KLPIGRPIANQ 1310 Query: 2823 QLYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREELTREKFVPDPFQTSGMMYRTGDLV 2882 Q+Y++D+N + IG+ GEL I GDG++RGYLNR ELT EKF+ +P+ ++ +Y+TGDL Sbjct: 1311 QVYILDKNLEPVPIGVSGELHIGGDGLARGYLNRPELTAEKFISNPWNSAEKLYKTGDLA 1370 Query: 2883 RMLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVII-STGPTDSRYLCA 2941 R L DGN+EF+GR+DDQVKIRG RIELGE+E L P + +A VI GP + R L A Sbjct: 1371 RYLADGNIEFVGRIDDQVKIRGFRIELGEVETALDSHPQIQQAVVIPREDGPGNKR-LIA 1429 Query: 2942 YYTAD 2946 Y D Sbjct: 1430 YVVCD 1434 Score = 533 bits (1373), Expect = e-149, Method: Compositional matrix adjust. Identities = 377/1244 (30%), Positives = 630/1244 (50%), Gaps = 75/1244 (6%) Query: 2086 LHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLH-DEPVQVIHDDIPF--------SISY 2136 L + G ++ E A+Q++V RH LRT F ++P+Q++ + +S Sbjct: 3568 LGLTGNIELLAFESAWQKVVDRHSVLRTFFVAEDVEKPLQIVLKQVKLPWENMDWRGLSQ 3627 Query: 2137 SIAEDEDEPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGISANILCN 2196 +++ + L + + F LNQAPL + ++ S++ + ++ HHI+ DG I+ Sbjct: 3628 QKQQEQLDELLSSQRLEGFQLNQAPLMKCILIELSENNYKFVLSSHHILMDGWCLPIIFK 3687 Query: 2197 DLISLYSGE------NLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSD-DIPSLT 2249 +++S+Y E NLP Y+DY + L + ++WQ+ L P+ Sbjct: 3688 EVLSIYEAEIQGKNFNLPRPR-PYEDYI----DWLKLQNKETASQFWQETLQGFTAPT-- 3740 Query: 2250 LPLDFPRPPVQS-FDGACYS---VTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKY 2305 PL + Q+ + + Y + L L+R L+ LS + TL T++ + +LLS Y Sbjct: 3741 -PLVVEKSQYQTQLNKSNYQEIELRLSPQLSRELQALSQKYHLTLSTIMQGVWGLLLSGY 3799 Query: 2306 SNQEDIVIGSPVAGRFNY--STNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAF 2363 S +EDIV G V+GR VG+F+NTL +R Q + +L E+++ +A Sbjct: 3800 SGEEDIVFGVTVSGRPPSLPEVEKRVGLFINTLPLRIQIPPQQQLIPWLEEIQQLMSQA- 3858 Query: 2364 ENQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLA---VPDVHLDDIRLNGYEFKND 2420 QDY + L+ + P+F+ + V ++ + D L+ ++ +E N Sbjct: 3859 --QDYAYTPLVDIKAVSEVPGGMPLFETIMVFENYPIGRSLTKDSALEISKIQSFEQTN- 3915 Query: 2421 VAKFDLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDL 2480 + L + + E L + Y F+ TI RMSE + + +V+N + +I L Sbjct: 3916 ---YPLTVMAVPG-EQLLIRVSYDTVRFESETIERMSEHLETMFSAIVKNPQQRVREIPL 3971 Query: 2481 LPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTN 2540 L + E +L++ +NDT Y V QLFE Q +TP AVA+ + + +TY+ N K N Sbjct: 3972 LTETERHQLLWEWNDTKVEY-SLLCVDQLFEAQVEKTPDAVAVEFEDQKLTYQQLNTKAN 4030 Query: 2541 QMARMLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDS 2600 Q+A LR GVKP+ VGI +E S E++I + A++KAGGAY+P+DP YP ERI FI++++ Sbjct: 4031 QLAHYLRCLGVKPEVLVGICVERSLEMVIGLLAILKAGGAYLPLDPNYPQERIQFILEET 4090 Query: 2601 NLEIMLTHKGLAE---KCQFQGEFIDAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTG 2657 + ++LT L + K + Q ID S N S + D+LAY IYTSGSTG Sbjct: 4091 QVPVLLTQASLLDAMPKHRAQVLCIDKDSPDIEQQSQENITSEVTTDNLAYTIYTSGSTG 4150 Query: 2658 LPKGVMTRHQGLTNYVWWGDKTYVHGEAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYS 2717 PKGV H L+N+++ + ++ +FD++ +++PL+ G ++ + S Sbjct: 4151 KPKGVQIPHSALSNFLFSMKEEPGLSSKDTLLAVTTYSFDIAALELFLPLVVGARLIVAS 4210 Query: 2718 G--VSYESLLEAVVIDNQVDFIMLTPSHLKILGEYDLSRLKIRKFIIGGEAFDPFYAKKF 2775 V+ + L A + D++ + TP+ K+L D + K + GGEA A + Sbjct: 4211 QEIVADGTQLLATLTDSKTTVMQATPATWKLLIAADWQGNEQLKVLCGGEALPSQLASEL 4270 Query: 2776 FSRLAEDVEVYNVYGPTETTVACTFYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNGKLQG 2835 R ++N+YGPTETT+ D L + IG I N QLY++DQ+ +L Sbjct: 4271 LERCE---SLWNMYGPTETTIWSAVSEIKTDSQL---ISIGNGIANTQLYILDQSSQLVP 4324 Query: 2836 IGIPGELCIAGDGVSRGYLNREELTREKFVPDPF-QTSGMMYRTGDLVRMLQDGNVEFLG 2894 +G+ GELCI G G++RGY R EL +EKF+ +PF + +YRTGDL R L +G +E+LG Sbjct: 4325 VGVVGELCIGGMGLARGYFERPELNKEKFIYNPFSEEESRIYRTGDLARYLPNGEIEYLG 4384 Query: 2895 RMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTA--DFPMNXX 2952 R+D+QVKIRG RIELGEIE Q+ + V +A VI + L AY + +N Sbjct: 4385 RIDNQVKIRGFRIELGEIETQIAQYTAVKEAVVIAREDIAGDKRLVAYIVPQEELAVNPS 4444 Query: 2953 XXXXXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIEE 3012 P +M+PS FV ++ +PLT +GK+DRK LP+ E+ + + P IEE Sbjct: 4445 ELREFLGEKLPNYMIPSAFVMLEKLPLTPNGKIDRKALPEPQETEILSEEIVLPSTPIEE 4504 Query: 3013 KLALVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRLKK-YGLSLEVKELFLHQNIKGI 3071 LA + ++LGI VG N+F +LGG S+ A ++VS++++ + + L ++ LF I + Sbjct: 4505 LLAGILSKILGIETVGVHNNFFELGGHSLIATRVVSQIRQVFNVELPLRSLFEKPTIAEL 4564 Query: 3072 SPFVKQ-----------NIKRHNQGTIEGPVKLTAIQKWFFEQNFAEMHHWNQSILLHNE 3120 + +++ +I+R ++ E P+ + WF + + +N S + + Sbjct: 4565 AKEIEKVINSDVEVEFVSIERVSRNR-ELPLSFAQQRLWFLAELEPDSPFYNISGAVKLQ 4623 Query: 3121 -RFDVQFIRQAFQRITEHHDALRMVYR-HTGQA-GVEQSNRGLAGELFSLEVTDLTGCDD 3177 + +V+ + Q+F I H+ LR ++ GQA V R L L +++++ L G Sbjct: 4624 GQLNVEALEQSFNEIVRRHENLRTNFQTRDGQAVAVISPERPL--NLSTVDISSLNGSTQ 4681 Query: 3178 HTDLMHAGIKTIQKGIDLEKGPLLKLGLYQTTNGDYLAIV-IHHLVVDGVSWRIILDDFA 3236 + K +K D+ K LL++ L + + +V +HH++ DG S + + + Sbjct: 4682 EEKVRQEITKEAEKPFDISKDLLLRIKLLHLGEEENIVLVTMHHIISDGWSMGVFIKELG 4741 Query: 3237 SCYLSLDNGEEAGLIEKSDSYQKWAEALEVYANSPKLLQELAYW 3280 + Y + N E L E Y +A + L +++YW Sbjct: 4742 TLYTNFCNQEPISLQELPIQYVDFAAWQREWLQGEVLENQVSYW 4785 Score = 362 bits (928), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 228/725 (31%), Positives = 386/725 (53%), Gaps = 40/725 (5%) Query: 1801 ILDKDMHPSPVGVPGEVY-----LAR-------------LTEPSLLAEQPSTSTGIMAMY 1842 ILD+ PVGV GE+ LAR + P E TG +A Y Sbjct: 5370 ILDQSSQLVPVGVVGELCIGGEGLARGYFQRRELNKEKFIYNPFSEEESRIYRTGDLARY 5429 Query: 1843 TADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAY 1902 + EI+ +G + G I L I+ Q+ + + A V + D++++AY Sbjct: 5430 LPNGEIEYLGRIDNQVKIRGFRIELGEIETQIAQYTAVKEAVVIARED--IAGDKRLVAY 5487 Query: 1903 ITPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALR 1962 I P+ E+++FL ++P IPSAF++L+++PL G I+ + LP ++ Sbjct: 5488 IVPQEELAVNPSELREFLGEKLPNYMIPSAFVMLEKLPLTPNGKIDRKALPVPEKTPISS 5547 Query: 1963 EEIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDISL 2022 EI+LP EE LA IW +L +E V ++DFFELGG+SL A+ + I++ F+ DI L Sbjct: 5548 NEIVLPSTPIEELLAGIWTEILGIETVGIHNDFFELGGHSLIATRIMSQIRQVFNVDIPL 5607 Query: 2023 RMLFEHPTVKGLAK----AINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGGAGT 2078 R LFE PT+ LAK IN + I + ++ P S +Q+RL+ + Q+ Sbjct: 5608 RNLFEKPTIAELAKEIEKVINSDVGVEVVSIERVSREQELPLSFAQQRLWFLAQIEPDSP 5667 Query: 2079 AYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSISYSI 2138 YN++ + VEG ++ +E++F +++RHE LRT+F + + P+Q+I + I+ Sbjct: 5668 FYNMSSTIEVEGSINVAVLEQSFNEIIRRHESLRTTFAMGENGPIQIIAPEQSIKITTID 5727 Query: 2139 AEDED---EPELVKRFIL-----PFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGIS 2190 + D + E V++ L PF+L L R+ ++ + ++++++++HHII+D S Sbjct: 5728 LHNLDVNEQTEQVQKLALEEAQTPFNLADGLLIRISLLQLGERKNVLLLNIHHIISDAWS 5787 Query: 2191 ANILCNDLISLYSG------ENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDD 2244 +L +L + Y LP L +QY D+ + L E++ +Q YW+Q LS Sbjct: 5788 MGVLVKELATFYENLVNDKPVQLPELPIQYADFAVWQRQPLQAEKLDKQLAYWRQQLSGV 5847 Query: 2245 IPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSK 2304 S +P D PRP +Q+F GA +L ++L+ + LS + TL+ LLA+ +LL K Sbjct: 5848 PDSFNIPTDKPRPELQTFRGAVSEFSLSTELSEKVTHLSRQEGVTLFMTLLATLQLLLYK 5907 Query: 2305 YSNQEDIVIGSPVAGRFNYSTNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFE 2364 Y Q+D+++G+ VA R +++G F+N L +R + + TF+E L +V+E TL A+ Sbjct: 5908 YKKQKDVLVGTDVANRNYKEVESLIGFFINILVLRANFSGNPTFRELLEQVREVTLGAYA 5967 Query: 2365 NQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKF 2424 NQD+PF +L+ + ER++SR P+F V+FVL + +P + + ++ + +KF Sbjct: 5968 NQDFPFTKLVETVRPERNLSRTPLFQVLFVLN--NTPIPQLEVSGLKFTPLMVDTETSKF 6025 Query: 2425 DLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKE 2484 D+ L V E L ++Y + LF ST+ R+S +F +L +V N + +++L KE Sbjct: 6026 DMALFVSETETGLKGMWQYNSDLFDLSTMTRLSAQFETLLNNIVNQPNTSIESLEILTKE 6085 Query: 2485 ETDRL 2489 E D++ Sbjct: 6086 EQDKM 6090 Score = 172 bits (436), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 185/744 (24%), Positives = 331/744 (44%), Gaps = 109/744 (14%) Query: 1801 ILDKDMHPSPVGVPGEVYL-----AR--LTEPSLLAEQ----PST---------STGIMA 1840 ILD ++ P PVGVPGE+YL AR L P L AE+ P + TG + Sbjct: 2794 ILDANLQPVPVGVPGELYLGGVQLARGYLNRPELTAERFIENPFSEDFSSPRLYKTGDLV 2853 Query: 1841 MYTADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKIL 1900 Y AD I+ +G + G I L I+ L HP + V P +++++ Sbjct: 2854 RYLADGNIEYLGRIDNQVKIRGFRIELGEIETLLASHPEVLETVVI--PKEETPGNKRLV 2911 Query: 1901 AYITPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKA 1960 AY+ R K+ EI++FL +++P IPSAF+ L+ +PL G ++ ++L E+ + Sbjct: 2912 AYLVIRPEITIKIEEIRQFLKAKLPNYMIPSAFVTLEALPLTPNGKVDRKILLESQEEIS 2971 Query: 1961 LREEIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDI 2020 +E + PE E EE L +IW+ VL LE V +D+FFE+GG+S+ S+ S K I Sbjct: 2972 RSKEYVAPETEIEETLVKIWQEVLLLEKVGIHDNFFEIGGDSI-LSIKVVSRAKNAGLQI 3030 Query: 2021 SLRMLFEHPTVKGLA-----KAINGAGKSFLPEITPLGK-KDWYPQSSSQKRLFAIEQMG 2074 + +FE+ T+ LA K A + + I PL + W+ +++ Sbjct: 3031 RSKQIFENQTIAELALVAKIKTETIAEQGIVTGIAPLTPIQKWF-----------LDKNP 3079 Query: 2075 GAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSF--ELLHDEPVQ----VIHD 2128 +N + IL + G+++ +E++ Q+L++ H+ LR F E L D+ + V + Sbjct: 3080 KEAHHFNQSVILEIPGEIEAEIVEKSVQKLLEHHDALRLRFNRETLEDKQINEGLGVTNL 3139 Query: 2129 DIPFSISYSIAEDEDE--PELVKRFILPFSLNQAPLFRVHI--VSRSDHEHIVIMDMHHI 2184 +S + E + E E+ F +L PL +V + + +D+ ++I+ +HH+ Sbjct: 3140 LTIVDLSSTPKEYQGERIAEIATEFQGSLNLRNGPLMQVVLFNLGEADNNRLLII-IHHL 3198 Query: 2185 IADGISANILCNDL------ISLYSGENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQ 2238 + DG+S IL +DL ++ L + + + N+ E + + +YW Sbjct: 3199 VVDGVSWRILLSDLEEISQKLTAQEPAKLREKTIAFIKWAEELNKYAQTEEVEAELDYW- 3257 Query: 2239 QLLSDDIPSLTLPLDFPRPPVQSFDGACYSVT--LDSDLTRG-LKVLSNRLKTTLYTLLL 2295 L + + +PLD ++ G V+ L + TR L ++ T + +LL Sbjct: 3258 -LYKNWTKTGVIPLDCEEKEPENLVGDVVQVSRKLSVEATRKLLGEVNEAYNTQINDILL 3316 Query: 2296 ASYNILLSKYSNQEDIVIGSPVAGRFNY----STNNMVGMFVNTLAMRNQPAKHKTFQEF 2351 ++ I+L +++N ++I GR + VG F + + + + E Sbjct: 3317 SALKIVLGEWTNSSSVIINLEGHGREELFEEVDLSRTVGWFTSLFPVLLETPEQIQIGEI 3376 Query: 2352 LLEVKENTLEAFENQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLDDIR 2411 + +KE L N+ + GI R +S +P A+P +I Sbjct: 3377 IKSIKEQ-LREIPNRGMGY-------GILRYLSESPDIKEKIA------AIPQ---GEIS 3419 Query: 2412 LN------------GYEFKNDVAKF--------DLILE----VIENTENLTLNFEYCAKL 2447 N G++F + D IL+ +IE L + + Y L Sbjct: 3420 FNYLGQFDQVGEETGWKFAKEPKGVNQSLKQNRDHILDINSLIIEG--KLQIEWTYNKNL 3477 Query: 2448 FQESTIIRMSERFLRILTTVVENC 2471 + TI ++++++L+ L ++E+C Sbjct: 3478 HSQETIEKLAKKYLKTLENIIEHC 3501 Score = 170 bits (430), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 108/393 (27%), Positives = 198/393 (50%), Gaps = 4/393 (1%) Query: 1363 LRGELNKAALETAYHKVLNRHESLRSTI-SADGNE-QIVASHANADIFFADILADYSALG 1420 L+G+LN ALE ++++++ RHE+LR+ + DG +++ ++ DI + + Sbjct: 2040 LQGQLNVEALEQSFNEIVRRHENLRTNFQTRDGQAVAVISPERPLNLSTVDISSLNGSTQ 2099 Query: 1421 DEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIADGWSLIVFLQELA 1480 +E + Q + KE FD L+R+++L E ++ ++ HHII+DGWS+ VF++EL Sbjct: 2100 EEKVRQEITKEAEKPFDISKDLLLRIKLLHLGEEENIVLVTMHHIISDGWSMGVFIKELG 2159 Query: 1481 ALYSTECTGTR-SLLPTPTPFSDYAIWQKRMLESQPKEKAAAYWKNKFSVQTPAFELPSF 1539 LY+ C SL P + D+A WQ+ L+ + E +YW + ELP+ Sbjct: 2160 TLYTNFCNQEPISLQELPIQYVDFAAWQREWLQGEVLENQVSYWLKQLENTPKLLELPTN 2219 Query: 1540 RIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVSLFTVLLSAYKVLLYRISNHKELVV 1599 + R A G+ H + L L+ L +SQ +LF LL+ ++ LL+R + +++VV Sbjct: 2220 KPRPAIQTFNGATHSFELSKELSLALNKLSQQKGSTLFMTLLAGFQTLLWRYTAQEDVVV 2279 Query: 1600 GIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXXXXXXXXQDYSYASL 1659 G P A + + + L+G+ +N L T + +F QD + L Sbjct: 2280 GSPIANRNRGEIEGLIGFFVNTLVLRTNLAENPSFSELLEQVREVTLGAYSHQDVPFELL 2339 Query: 1660 MKELHSLDGSVHPPQINTMFNMDKS-LETPDFTGMDVELLQSPVSYSKYDLSMNIVELDH 1718 ++ L H P MF + + + + G+ + L++ +K+DLS+ + E + Sbjct: 2340 VERLQPERDLSHSPLFQVMFVLQNAPMSALELPGVTLTSLENKHQTAKFDLSLYMTETES 2399 Query: 1719 ELMIDFEYDPNLFDTQIITGWANYFNRILLAVL 1751 L+ +FEY+ +LF+ + IT + R+L A++ Sbjct: 2400 GLVGNFEYNTDLFEEKTITRMVGHLERLLSAIV 2432 Score = 169 bits (429), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 108/393 (27%), Positives = 197/393 (50%), Gaps = 4/393 (1%) Query: 1363 LRGELNKAALETAYHKVLNRHESLRSTI-SADGNE-QIVASHANADIFFADILADYSALG 1420 L+G+LN ALE ++++++ RHE+LR+ + DG +++ ++ DI + + Sbjct: 4622 LQGQLNVEALEQSFNEIVRRHENLRTNFQTRDGQAVAVISPERPLNLSTVDISSLNGSTQ 4681 Query: 1421 DEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIADGWSLIVFLQELA 1480 +E + Q + KE FD L+R+++L E ++ ++ HHII+DGWS+ VF++EL Sbjct: 4682 EEKVRQEITKEAEKPFDISKDLLLRIKLLHLGEEENIVLVTMHHIISDGWSMGVFIKELG 4741 Query: 1481 ALYSTECTGTR-SLLPTPTPFSDYAIWQKRMLESQPKEKAAAYWKNKFSVQTPAFELPSF 1539 LY+ C SL P + D+A WQ+ L+ + E +YW + ELP+ Sbjct: 4742 TLYTNFCNQEPISLQELPIQYVDFAAWQREWLQGEVLENQVSYWLKQLENTPKLLELPTN 4801 Query: 1540 RIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVSLFTVLLSAYKVLLYRISNHKELVV 1599 + R A G+ H + L L+ L +SQ +LF LL+ ++ LL+R + +++VV Sbjct: 4802 KPRPAIQTFNGATHSFELSKELSLALNKLSQQKGSTLFMTLLAGFQTLLWRYTAQEDVVV 4861 Query: 1600 GIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXXXXXXXXQDYSYASL 1659 G P A + + + L+G+ +N L T + +F QD + L Sbjct: 4862 GSPIANRNRGEIEGLIGFFVNTLVLRTNLAENPSFSELLEQVREVTLGAYSHQDVPFELL 4921 Query: 1660 MKELHSLDGSVHPPQINTMFNMDKS-LETPDFTGMDVELLQSPVSYSKYDLSMNIVELDH 1718 ++ L H P MF + + + + G+ + L++ +K+DLS+ + E + Sbjct: 4922 VERLQPERDLSHSPLFQVMFVLQNAPMSALELPGVTLTSLENKHQTAKFDLSLYMTETES 4981 Query: 1719 ELMIDFEYDPNLFDTQIITGWANYFNRILLAVL 1751 L+ FEY+ +LF+ + IT + R+L A++ Sbjct: 4982 GLVGSFEYNTDLFEEETITRMVGHLERLLSAIV 5014 Score = 160 bits (405), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 103/397 (25%), Positives = 192/397 (48%), Gaps = 10/397 (2%) Query: 1363 LRGELNKAALETAYHKVLNRHESLRSTI-SADGNE-QIVASHANADIFFADILADYSALG 1420 ++G LN LE ++++++ RHE+LR+ + DG ++AS + D+ + + Sbjct: 568 IQGHLNLEVLEQSFNEIIRRHETLRTNFQTRDGKAVAVIASERPIKLSIVDVSSLSGSTQ 627 Query: 1421 DEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIADGWSLIVFLQELA 1480 +E + Q +E FD PL+R+++L + E L+ ++ HHII+DGWS+ V LQEL Sbjct: 628 EEKVKQETAEEAEKPFDISNDPLLRVKLLRLEQEENLILVTLHHIISDGWSIGVLLQELT 687 Query: 1481 ALYSTECTGT-RSLLPTPTPFSDYAIWQKRMLESQPKEKAAAYWKNKFSVQTPAFELPSF 1539 LY+ +L P + D+A WQ++ L+ + E +YW + ELP+ Sbjct: 688 TLYTNFYNQEPLALQELPIQYVDFAAWQRQWLQGEVLENQMSYWLKQLENAPEVLELPAD 747 Query: 1540 RIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVSLFTVLLSAYKVLLYRISNHKELVV 1599 R A +G + + L L+ L +S+ +LF LL+ ++ LL+R + +++VV Sbjct: 748 NPRQAIQSYRGKIYSFNLSKELSTSLNELSEQQGTTLFMTLLAGFQTLLWRYTAQEDIVV 807 Query: 1600 GIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXXXXXXXXQDYSYASL 1659 G P A + + + L+G+ +N L T + +F QD + L Sbjct: 808 GSPIANRNRAEVEGLIGFFVNSLVLRTNLAGNPSFEELLKQVREVALGAYAHQDVPFDLL 867 Query: 1660 MKELHSLDGSVHPPQINTMFNMDKSLETP----DFTGMDVELLQSPVSYSKYDLSMNIVE 1715 ++ L H P +F + L TP D + +L++ ++ DL + + E Sbjct: 868 VERLQPERQLSHNPLFQVVFAL---LNTPMSDLDLPDATLTVLRNDSGIARCDLILYMTE 924 Query: 1716 LDHELMIDFEYDPNLFDTQIITGWANYFNRILLAVLQ 1752 + + FEY+ +LF+ + I+ A + +L A+++ Sbjct: 925 TESGIAGQFEYNTDLFEEKTISRMAGHIQTLLSAIVE 961 Score = 152 bits (383), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 103/397 (25%), Positives = 196/397 (49%), Gaps = 5/397 (1%) Query: 1363 LRGELNKAALETAYHKVLNRHESLRSTISA--DGNEQIVASHANADIFFADILADYSALG 1420 + G +N A LE ++++++ RHESLR+T + +G QI+A + I D+ Sbjct: 5677 VEGSINVAVLEQSFNEIIRRHESLRTTFAMGENGPIQIIAPEQSIKITTIDLHNLDVNEQ 5736 Query: 1421 DEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIADGWSLIVFLQELA 1480 E + + L+E F+ G LIR+ +L + +L L+ HHII+D WS+ V ++ELA Sbjct: 5737 TEQVQKLALEEAQTPFNLADGLLIRISLLQLGERKNVLLLNIHHIISDAWSMGVLVKELA 5796 Query: 1481 ALYSTECTGTRSLLPT-PTPFSDYAIWQKRMLESQPKEKAAAYWKNKFSVQTPAFELPSF 1539 Y LP P ++D+A+WQ++ L+++ +K AYW+ + S +F +P+ Sbjct: 5797 TFYENLVNDKPVQLPELPIQYADFAVWQRQPLQAEKLDKQLAYWRQQLSGVPDSFNIPTD 5856 Query: 1540 RIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVSLFTVLLSAYKVLLYRISNHKELVV 1599 + R +G+ + L L+ K+ +S+ V+LF LL+ ++LLY+ K+++V Sbjct: 5857 KPRPELQTFRGAVSEFSLSTELSEKVTHLSRQEGVTLFMTLLATLQLLLYKYKKQKDVLV 5916 Query: 1600 GIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXXXXXXXXQDYSYASL 1659 G A + + L+G+ +NIL + TFR QD+ + L Sbjct: 5917 GTDVANRNYKEVESLIGFFINILVLRANFSGNPTFRELLEQVREVTLGAYANQDFPFTKL 5976 Query: 1660 MKELHSLDGSVHPPQINTMFNMDKS-LETPDFTGMDVELLQSPVSYSKYDLSMNIVELDH 1718 ++ + P +F ++ + + + +G+ L SK+D+++ + E + Sbjct: 5977 VETVRPERNLSRTPLFQVLFVLNNTPIPQLEVSGLKFTPLMVDTETSKFDMALFVSETET 6036 Query: 1719 ELMIDFEYDPNLFDTQIITGWANYFNRILLAVL-QPD 1754 L ++Y+ +LFD +T + F +L ++ QP+ Sbjct: 6037 GLKGMWQYNSDLFDLSTMTRLSAQFETLLNNIVNQPN 6073 Score = 122 bits (307), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 106/466 (22%), Positives = 217/466 (46%), Gaps = 36/466 (7%) Query: 3557 DVYTMTPMQESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRF 3616 + Y ++ Q+ + F A + Y+ + ++G + E+L +SF I+ +++ LRT F Sbjct: 536 NFYQLSFAQKRIWFLAELEPDNPFYNISGTVRIQGHLNLEVLEQSFNEIIRRHETLRTNF 595 Query: 3617 VYKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGPLMRAI 3676 + + + ++ L D++ + S + +++ A + EK FD+ PL+R Sbjct: 596 QTRD-GKAVAVIASERPIKLSIVDVSSLSGSTQEEKVKQETAEEAEKPFDISNDPLLRVK 654 Query: 3677 LLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSLETHQYRLYLD--- 3733 LL+ +L + HHI+ DGW IG++L+++ Y +L+ + Y+D Sbjct: 655 LLRLEQEENLILVTLHHIISDGWSIGVLLQELTTLYTNFYNQEPLALQELPIQ-YVDFAA 713 Query: 3734 ----WLASKNKEEAKVYWMQYLEDYKYKELLRKEGTS-----KEFRLAVLDIKLEEKVRT 3784 WL + E YW++ LE+ E+L + + +R + L +++ T Sbjct: 714 WQRQWLQGEVLENQMSYWLKQLEN--APEVLELPADNPRQAIQSYRGKIYSFNLSKELST 771 Query: 3785 AVTHVASSSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGRS-PEIEGIERMVGLFIN 3843 ++ ++ G T+ A + LL +Y ED+V G+ I+ R+ E+EG ++G F+N Sbjct: 772 SLNELSEQQGTTLFMTLLAGFQTLLWRYTAQEDIVVGSPIANRNRAEVEG---LIGFFVN 828 Query: 3844 TIPVRVRLSGK-TFHELAGEIQSSFISSEQYGYVP-------LSDIQAWSHRDLINHVMV 3895 ++ +R L+G +F EL +++ + + + VP L + SH L V Sbjct: 829 SLVLRTNLAGNPSFEELLKQVREVALGAYAHQDVPFDLLVERLQPERQLSHNPLFQVVFA 888 Query: 3896 FENYPL-DREIRDTDGQQMEYGFQIAGCEILEHTNYDFSIIIEPGEDFIIRIVYNALAYD 3954 N P+ D ++ D + IA C+++ + S I E YN ++ Sbjct: 889 LLNTPMSDLDLPDATLTVLRNDSGIARCDLILYMTETESGIAGQFE-------YNTDLFE 941 Query: 3955 KETISILESYLLAIIGQVTACPQIEAGDVEVLSQEEKLKLMNVFNK 4000 ++TIS + ++ ++ + PQ + ++ +L E+ +L+ +N+ Sbjct: 942 EKTISRMAGHIQTLLSAIVENPQQKVSEIPLLRATERHQLLVEWNE 987 Score = 115 bits (287), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 109/462 (23%), Positives = 211/462 (45%), Gaps = 36/462 (7%) Query: 3565 QESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRFVYKKLHRP 3624 Q+ + F A S Y+ ++++G I +L +SF I+ +++ LRT F + + P Sbjct: 5653 QQRLWFLAQIEPDSPFYNMSSTIEVEGSINVAVLEQSFNEIIRRHESLRTTFAMGE-NGP 5711 Query: 3625 LQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGPLMRAILLKTGDSV 3684 +QI+ + D+ +++ +E+ +++L + + F+L G L+R LL+ G+ Sbjct: 5712 IQIIAPEQSIKITTIDLHNLDVNEQTEQVQKLALEEAQTPFNLADGLLIRISLLQLGERK 5771 Query: 3685 YQMLWSFHHILMDGWCIGIVLKDMLEHYKQL---NAGSRPSLETHQYRLYLDW----LAS 3737 +L + HHI+ D W +G+++K++ Y+ L P L QY + W L + Sbjct: 5772 NVLLLNIHHIISDAWSMGVLVKELATFYENLVNDKPVQLPELPI-QYADFAVWQRQPLQA 5830 Query: 3738 KNKEEAKVYWMQYLEDYKYKELLRKEGTSKE---FRLAVLDIKLEEKVRTAVTHVASSSG 3794 + ++ YW Q L + + E FR AV + L ++ VTH++ G Sbjct: 5831 EKLDKQLAYWRQQLSGVPDSFNIPTDKPRPELQTFRGAVSEFSLSTELSEKVTHLSRQEG 5890 Query: 3795 ITINSFFQAVWGILLSKYDNAEDVVFGAVISGRSPEIEGIERMVGLFINTIPVRVRLSGK 3854 +T+ A +LL KY +DV+ G ++ R+ + +E ++G FIN + +R SG Sbjct: 5891 VTLFMTLLATLQLLLYKYKKQKDVLVGTDVANRN--YKEVESLIGFFINILVLRANFSGN 5948 Query: 3855 -TFHELAGEIQSSFISSEQYGYVPLSDI-------QAWSHRDLINHVMVFENYPLDREIR 3906 TF EL +++ + + P + + + S L + V N P+ Sbjct: 5949 PTFRELLEQVREVTLGAYANQDFPFTKLVETVRPERNLSRTPLFQVLFVLNNTPIP---- 6004 Query: 3907 DTDGQQMEY-GFQIAGCEI-LEHTNYDFSIIIEPGEDFIIRI-VYNALAYDKETISILES 3963 Q+E G + + E + +D ++ + E + + YN+ +D T++ L + Sbjct: 6005 -----QLEVSGLKFTPLMVDTETSKFDMALFVSETETGLKGMWQYNSDLFDLSTMTRLSA 6059 Query: 3964 YLLAIIGQVTACPQIEAGDVEVLSQEE--KLKLMNVFNKPNR 4003 ++ + P +E+L++EE K+KL NK R Sbjct: 6060 QFETLLNNIVNQPNTSIESLEILTKEEQDKMKLAQTKNKKAR 6101 Score = 113 bits (282), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 101/414 (24%), Positives = 186/414 (44%), Gaps = 29/414 (7%) Query: 1354 VHHETVGLYLRGELNKAALETAYHKVLNRHESLRSTISADGNE---QIVASHANADIFFA 1410 V+ + + L L G + A E+A+ KV++RH LR+ A+ E QIV Sbjct: 3561 VYFQQIALGLTGNIELLAFESAWQKVVDRHSVLRTFFVAEDVEKPLQIVLKQVKLPWENM 3620 Query: 1411 DILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIADGW 1470 D E +++ L + F PL++ ++ + + Y LS+HHI+ DGW Sbjct: 3621 DWRGLSQQKQQEQLDELLSSQRLEGFQLNQAPLMKCILIELSENNYKFVLSSHHILMDGW 3680 Query: 1471 SLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQPKEKAAAYWKNKFSVQ 1530 L + +E+ ++Y E G LP P P+ DY W L+ Q KE A+ +W+ Sbjct: 3681 CLPIIFKEVLSIYEAEIQGKNFNLPRPRPYEDYIDW----LKLQNKETASQFWQETLQGF 3736 Query: 1531 TPAFELPSFRIRDAAGVRKGSRHRYVLDIP--LTAKLKAVSQSMKVSLFTVLLSAYKVLL 1588 T L + + + K + L + L+ +L+A+SQ ++L T++ + +LL Sbjct: 3737 TAPTPLVVEKSQYQTQLNKSNYQEIELRLSPQLSRELQALSQKYHLTLSTIMQGVWGLLL 3796 Query: 1589 YRISNHKELVVGIPTAGQ---MQMGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXX 1645 S +++V G+ +G+ + +K VG +N LP I P+ Sbjct: 3797 SGYSGEEDIVFGVTVSGRPPSLPEVEKR-VGLFINTLPLRIQIPPQQQL---IPWLEEIQ 3852 Query: 1646 XXXXXXQDYSYASL--MKELHSLDGSVHPPQINTM-----FNMDKSLETPDFTGMDVELL 1698 QDY+Y L +K + + G + P T+ + + +SL T D + +++ + Sbjct: 3853 QLMSQAQDYAYTPLVDIKAVSEVPGGM--PLFETIMVFENYPIGRSL-TKD-SALEISKI 3908 Query: 1699 QSPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQIITGWANYFNRILLAVLQ 1752 QS + Y L++ V +L+I YD F+++ I + + + A+++ Sbjct: 3909 QS-FEQTNYPLTVMAVP-GEQLLIRVSYDTVRFESETIERMSEHLETMFSAIVK 3960 Score = 108 bits (271), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 114/457 (24%), Positives = 213/457 (46%), Gaps = 34/457 (7%) Query: 3565 QESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRFVYKKLHRP 3624 Q+ + F A S Y+ + L+G + E L +SF IV +++ LRT F + + Sbjct: 4598 QQRLWFLAELEPDSPFYNISGAVKLQGQLNVEALEQSFNEIVRRHENLRTNFQTRD-GQA 4656 Query: 3625 LQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGPLMRAILLKTGDSV 3684 + ++ +L DI+ + S + + + + EK FD+ + L+R LL G+ Sbjct: 4657 VAVISPERPLNLSTVDISSLNGSTQEEKVRQEITKEAEKPFDISKDLLLRIKLLHLGEEE 4716 Query: 3685 YQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSLETHQYRLYLD-------WLAS 3737 +L + HHI+ DGW +G+ +K++ Y SL+ + Y+D WL Sbjct: 4717 NIVLVTMHHIISDGWSMGVFIKELGTLYTNFCNQEPISLQELPIQ-YVDFAAWQREWLQG 4775 Query: 3738 KNKEEAKVYWMQYLEDY-KYKELL--RKEGTSKEFRLAVLDIKLEEKVRTAVTHVASSSG 3794 + E YW++ LE+ K EL + + F A +L +++ A+ ++ G Sbjct: 4776 EVLENQVSYWLKQLENTPKLLELPTNKPRPAIQTFNGATHSFELSKELSLALNKLSQQKG 4835 Query: 3795 ITINSFFQAVWGILLSKYDNAEDVVFGAVISGRSP-EIEGIERMVGLFINTIPVRVRLS- 3852 T+ A + LL +Y EDVV G+ I+ R+ EIEG ++G F+NT+ +R L+ Sbjct: 4836 STLFMTLLAGFQTLLWRYTAQEDVVVGSPIANRNRGEIEG---LIGFFVNTLVLRTNLAE 4892 Query: 3853 GKTFHELAGEIQSSFISSEQYGYVP-------LSDIQAWSHRDLINHVMVFENYPLDR-E 3904 +F EL +++ + + + VP L + SH L + V +N P+ E Sbjct: 4893 NPSFSELLEQVREVTLGAYSHQDVPFELLVERLQPERDLSHSPLFQVMFVLQNAPMSALE 4952 Query: 3905 IRDTDGQQMEYGFQIAGCEILEHTNYDFSIIIEPGEDFII-RIVYNALAYDKETISILES 3963 + +E Q A +D S+ + E ++ YN +++ETI+ + Sbjct: 4953 LPGVTLTSLENKHQTA--------KFDLSLYMTETESGLVGSFEYNTDLFEEETITRMVG 5004 Query: 3964 YLLAIIGQVTACPQIEAGDVEVLSQEEKLKLMNVFNK 4000 +L ++ + A P+ D+ +LS+ E+ +L++ +N+ Sbjct: 5005 HLERLLSAIVANPEQRLSDLPLLSEPEQHQLLSEWNE 5041 Score = 79.7 bits (195), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 174/880 (19%), Positives = 331/880 (37%), Gaps = 148/880 (16%) Query: 2840 GELCIAGDGVSRGYLNREELTREKFVPDPFQTSGMMY-RTGDLVRMLQDGNVEFLGRMDD 2898 GE+ + G +++GY NR + T + F + RTGDL + ++G + GR+ D Sbjct: 241 GEIWVRGQSIAQGYWNRIQETEQTFKARLTNNEKDYFLRTGDLGFLDEEGELFITGRLKD 300 Query: 2899 QVKIRGHR-----IELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTADFPMNXXX 2953 + IRG IEL + + G N A V+ + P Sbjct: 301 LIIIRGRNLYPQDIELTAETSHQALRLGSNAAFVVEENKEEKLVIIQELEFRAKPNLEEV 360 Query: 2954 XXXXXXXXXPRHMVPSF---FVQMKSIPLTASGKVDRKKLPDSFESFQME---DAYSAPQ 3007 H + + ++ IP T+SGK+ R+ F ++ ++ + Sbjct: 361 LIAIRQAVTEFHEIEVYSVVLIKPGRIPKTSSGKIQRRATRQMFLKGTLDIVANSVLETE 420 Query: 3008 NFIEEKLALVWEEVLGINK-------------------------VGTSNSFIKLGGDSIK 3042 + + L E+L ++K + + LG DSIK Sbjct: 421 KVVGIETKLTRRELLELSKQQSQSELEIYLRSLILSILRRTDQDIDLNTPLTNLGLDSIK 480 Query: 3043 AIQIVSRLKK-YGLSLEVKELFLHQNIKGISPFV-----------KQNIKRHNQGTIEGP 3090 + +++++ G+++ +++ F NIK + + + I H G Sbjct: 481 VFEFKNKIEEDMGVTIPIEDFFAELNIKSLCNQILAQLDTPVEASRAIIPTHRDGNF--- 537 Query: 3091 VKLTAIQK--WFFEQNFAEMHHWNQSILLHNE-RFDVQFIRQAFQRITEHHDALRMVY-- 3145 +L+ QK WF + + +N S + + +++ + Q+F I H+ LR + Sbjct: 538 YQLSFAQKRIWFLAELEPDNPFYNISGTVRIQGHLNLEVLEQSFNEIIRRHETLRTNFQT 597 Query: 3146 RHTGQAGVEQSNRGLAGELFSLEVTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGL 3205 R V S R + +L ++V+ L+G + + +K D+ PLL++ L Sbjct: 598 RDGKAVAVIASERPI--KLSIVDVSSLSGSTQEEKVKQETAEEAEKPFDISNDPLLRVKL 655 Query: 3206 YQTTNGDYLAIV-IHHLVVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEAL 3264 + + L +V +HH++ DG S ++L + + Y + N E L E Y +A Sbjct: 656 LRLEQEENLILVTLHHIISDGWSIGVLLQELTTLYTNFYNQEPLALQELPIQYVDFAAWQ 715 Query: 3265 EVYANSPKLLQELAYWTDV--NRIAVPALPKDS-----EAGNGKI------KDRYQTKTV 3311 + L +++YW N V LP D+ ++ GKI K+ + Sbjct: 716 RQWLQGEVLENQMSYWLKQLENAPEVLELPADNPRQAIQSYRGKIYSFNLSKELSTSLNE 775 Query: 3312 LSEKETTNLLRHAGDAYQTETXXXXXXXXXXXIKGWANVDRVRINMEGHGREALIQDLDI 3371 LSE++ T L +Q T + G +R R +EG Sbjct: 776 LSEQQGTTLFMTLLAGFQ--TLLWRYTAQEDIVVGSPIANRNRAEVEG------------ 821 Query: 3372 TRTVGWFTSTYPLVLELANSHELPLHIMTTKET-IRQTPNKGMGYQVLKYLTSPELRAAV 3430 +G+F ++ L LA + + +E + ++ + + +L PE Sbjct: 822 --LIGFFVNSLVLRTNLAGNPSFEELLKQVREVALGAYAHQDVPFDLLVERLQPER---- 875 Query: 3431 DFNVMPEISFNYLGQFGNEASYGTFEICNTFMESTESPESHRP---------------YA 3475 ++S N L Q F + NT M + P++ Y Sbjct: 876 ------QLSHNPLFQV-------VFALLNTPMSDLDLPDATLTVLRNDSGIARCDLILYM 922 Query: 3476 IDINAMIVGNRVEIRVDYNPGQFNEATMSRFAELLLNSLKLIISHCTRE----------E 3525 + + I G + +YN F E T+SR A + L I+ + ++ E Sbjct: 923 TETESGIAG-----QFEYNTDLFEEKTISRMAGHIQTLLSAIVENPQQKVSEIPLLRATE 977 Query: 3526 R----IQRSPSDLTY--KKLTFEELDDLNRLYPGGITDVYTMTPMQESMLFHALKNKRSD 3579 R ++ + ++L Y K + ++ + P GI V+ ++ + + L K + Sbjct: 978 RHQLLVEWNETELEYSQNKCIHQLFEEQVKTKPNGIAVVFE----EQQLTYEELNKKANQ 1033 Query: 3580 AYHEQCILDLKGD-IIQELLNESFKLIVGKYDILRTRFVY 3618 H L +K D ++ + S ++I+G IL+ Y Sbjct: 1034 LAHYLIKLGVKPDSLVGICVERSLEMIIGVLGILKAGGAY 1073 >sp|O30408|TYCB_BREPA Tyrocidine synthetase II [Includes: ATP-dependent proline adenylase (ProA) (Proline activase); ATP-dependent phenylalanine adenylase (PheA) (Phenylalanine activase); ATP-dependent D-phenylalanine adenylase (D-PheA) (D-phenylalanine activase); Phenylalanine racemase [ATP-hydrolyzing] ] pir||T31075 tyrocidine synthetase 2 - Brevibacillus brevis gb|AAC45929.1| tyrocidine synthetase 2 [Brevibacillus brevis] Length = 3587 Score = 1305 bits (3376), Expect = 0.0, Method: Compositional matrix adjust. Identities = 710/1775 (40%), Positives = 1031/1775 (58%), Gaps = 47/1775 (2%) Query: 1801 ILDKDMHPSPVGVPGEVY-----LAR--LTEPSLLAEQ----PST------STGIMAMYT 1843 I+D+ PVGV GE+ LAR +P L AE+ P+ TG + + Sbjct: 1828 IVDQHHQLLPVGVVGEICIGGHGLARGYWKKPELTAEKFVANPAVPGERMYKTGDLGRWL 1887 Query: 1844 ADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAYI 1903 D I IG + G I + I+ L+ + A V + D + AY+ Sbjct: 1888 HDGTIDFIGRVDDQIKVRGYRIEVGEIEAVLLAYDQTNEAIVVAYQDD--RGDSYLAAYV 1945 Query: 1904 TPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALRE 1963 T G + + E++ LL +P +P+ + LD PL G ++ + LP + A Sbjct: 1946 T--GKTAIEESELRAHLLRELPAYMVPTYLIQLDAFPLTPNGKVDRKALPKPEGKPATGA 2003 Query: 1964 EIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDISLR 2023 + P E E +L IW N L + V D FFELGG+SLKA + + +EF D+ L+ Sbjct: 2004 AYVAPATEVEAKLVAIWENALGISGVGVLDHFFELGGHSLKAMTVVAQVHREFQIDLLLK 2063 Query: 2024 MLFEHPTVKGLAKAINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGGAGTAYNIT 2083 F PT++ LA+ I + ++ I P + +YP SS+Q+R++ + Q+ GAG +YN Sbjct: 2064 QFFAAPTIRDLARLIEHSEQAAGAAIQPAEPQAYYPVSSAQQRMYLLHQLEGAGISYNTP 2123 Query: 2084 GILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSISYSIAEDED 2143 GI+ +EGKLD ++ A Q LV RH+ LRTSFE++ DE VQ IHD + ++ Y AE++ Sbjct: 2124 GIIMLEGKLDREQLANALQALVDRHDILRTSFEMVGDELVQKIHDRVAVNMEYVTAEEQQ 2183 Query: 2144 EPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGISANILCNDLISLYS 2203 +L F+ PF L+ PL R+ +V +D H+++ DMHHI AD S IL ++L LY Sbjct: 2184 IDDLFHAFVRPFDLSVPPLLRMSLVKLADERHLLLYDMHHIAADAASITILFDELAELYQ 2243 Query: 2204 GENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFD 2263 G LP + +QYKD+ + ++ +QQ YW + +I ++ +P DFPRP V+SF Sbjct: 2244 GRELPEMRIQYKDFAVWQKALHESDAFKQQEAYWLSTFAGNITAVDVPTDFPRPAVKSFA 2303 Query: 2264 GACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNY 2323 G ++++D +L L L+ TTL+ +LLA+YN+LL+KY+ Q+DI++G+P++GR Sbjct: 2304 GGQVTLSMDQELLSALHELAAHTNTTLFMVLLAAYNVLLAKYAGQDDIIVGTPISGRSRA 2363 Query: 2324 STNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERDI 2383 +VGMFV+TLA+RN+P KTF++FL EVK+N L+AF++QDYPFE L+ KLGI RD Sbjct: 2364 ELAPVVGMFVHTLAIRNKPTAEKTFKQFLQEVKQNALDAFDHQDYPFESLVEKLGIPRDP 2423 Query: 2384 SRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKN--DVAKFDLILEVIENTENLTLNF 2441 RNP+FD MF+LQ+ +L LD + YE + DVAKFDL + E +L L Sbjct: 2424 GRNPLFDTMFILQNDELHAKT--LDQLVYRPYESDSALDVAKFDLSFHLTERETDLFLRL 2481 Query: 2442 EYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYP 2501 EYC KLF++ T+ RM+ FL+IL V N L +I++L E L+ FNDT Y Sbjct: 2482 EYCTKLFKQQTVERMAHHFLQILRAVTANPENELQEIEMLTAAEKQMLLVAFNDTHREYR 2541 Query: 2502 GGKTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILM 2561 +T+ QLFEE A + P ALV + + +++ N + NQ+A +LR KGV P V +L+ Sbjct: 2542 ADQTIQQLFEELAEKMPEHTALVFEEKRMSFRELNERANQLAAVLREKGVGPAQIVALLV 2601 Query: 2562 EHSFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEF 2621 E S E++I+ A +KAGGA++P+DP YP ERI ++++DS ++++TH L K Q E Sbjct: 2602 ERSAEMVIATLATLKAGGAFLPVDPDYPEERIRYMLEDSQAKLVVTHAHLLHKVSSQSEV 2661 Query: 2622 IDAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYV 2681 +D Y N N+P DLAYIIYTSG+TG PKGVM H+G+ N + Sbjct: 2662 VDVDDPGSYATQTDNLPCANTPSDLAYIIYTSGTTGKPKGVMLEHKGVANL----QAVFA 2717 Query: 2682 HGEAVDFPL-----YSSIAFDLSVTLIYIPLISGNKVFIYSG--VSYESLLEAVVIDNQV 2734 H V P ++SI+FD SV ++ PL+SG +++ S ++ V DN + Sbjct: 2718 HHLGVT-PQDRAGHFASISFDASVWDMFGPLLSGATLYVLSRDVINDFQRFAEYVRDNAI 2776 Query: 2735 DFIMLTPSHLKILGEYDLSRLKIRKFIIGGEAFDPFYAKKFFSRLAEDVEVYNVYGPTET 2794 F+ L P++ L + L R I G A + + E V N YGPTE+ Sbjct: 2777 TFLTLPPTYAIYLEPEQVPSL--RTLITAGSA----SSVALVDKWKEKVTYVNGYGPTES 2830 Query: 2795 TVACTFYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRGYL 2854 TV T ++ PD+ + + IG PI N +LY+VD +L+ G GELCI+G ++RGY Sbjct: 2831 TVCATLWKAKPDEPVET-ITIGKPIQNTKLYIVDDQLQLKAPGQMGELCISGLSLARGYW 2889 Query: 2855 NREELTREKFVPDPFQTSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEIEN 2914 NR ELT EKFV +PF MYRTGDL R L DG +E+LGR+D QVKIRGHR+ELGE+E+ Sbjct: 2890 NRPELTAEKFVDNPFVPGTKMYRTGDLARWLPDGTIEYLGRIDHQVKIRGHRVELGEVES 2949 Query: 2915 QLVKQPGVNKAAVIISTGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFVQM 2974 L++ V +AA I YLCAYY A+ P +MVP+FF+Q+ Sbjct: 2950 VLLRYDTVKEAAAITHEDDRGQAYLCAYYVAEGEATPAQLRAYMENELPNYMVPAFFIQL 3009 Query: 2975 KSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNSFI 3034 + +PLT + K+DRK LP + + Y+APQ +E+ LA +W +VLGI +VGT ++F Sbjct: 3010 EKMPLTPNDKIDRKALPKPNQEENRTEQYAAPQTELEQLLAGIWADVLGIKQVGTQDNFF 3069 Query: 3035 KLGGDSIKAIQIVSRLKKYGLSLEVKELFLHQNIKGISPFVKQNIKRHNQGTIEGPVKLT 3094 +LGGDSIKAIQ+ +RL G +L +KELF + I+ + V N + QG +EG + LT Sbjct: 3070 ELGGDSIKAIQVSTRLNASGWTLAMKELFQYPTIEEAALRVIPNSRESEQGVVEGEIALT 3129 Query: 3095 AIQKWFFEQNFAEMHHWNQSILLHNER-FDVQFIRQAFQRITEHHDALRMVYRHTGQAGV 3153 IQKWFF NF + HHWNQ+++L E FD +RQAFQ+I EHHDALRMVY+ A + Sbjct: 3130 PIQKWFFANNFTDRHHWNQAVMLFREDGFDEGLVRQAFQQIVEHHDALRMVYKQEDGA-I 3188 Query: 3154 EQSNRGLAGELFSLEVTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGLYQTTNGDY 3213 +Q NRGL E F DL + + IQ IDLE GPL+ + L+ T +GD+ Sbjct: 3189 KQINRGLTDERFRFYSYDLKNHANSEARILELSDQIQSSIDLEHGPLVHVALFATKDGDH 3248 Query: 3214 LAIVIHHLVVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALEVYANSPKL 3273 L + IHHLVVDGVSWRI+ +DF+S Y + +E L +K+DS++ WA L+ YA+S +L Sbjct: 3249 LLVAIHHLVVDGVSWRILFEDFSSAYSQALHQQEIVLPKKTDSFKDWAAQLQKYADSDEL 3308 Query: 3274 LQELAYWTDVN-RIAVPALPKDSEAGNGKIKDRYQTKTVLSEKETTNLLRHAGDAYQTET 3332 L+E+AYW ++ ALP D + K K L+ +T NLLRH AY TE Sbjct: 3309 LREVAYWHNLETTTTTAALPTDFVTADRKQKHTRTLSFALTVPQTENLLRHVHHAYHTEM 3368 Query: 3333 XXXXXXXXXXXIKGWANVDRVRINMEGHGREALIQDLDITRTVGWFTSTYPLVLELANSH 3392 +K WA+ + V IN+EGHGRE + ++++TRT+GWFTS YP+VL++ + Sbjct: 3369 NDLLLTALGLAVKDWAHTNGVVINLEGHGREDIQNEMNVTRTIGWFTSQYPVVLDMEKAE 3428 Query: 3393 ELPLHIMTTKETIRQTPNKGMGYQVLKYLTSPELRAAVDFNVMPEISFNYLGQFGNEASY 3452 +LP I TKE +R+ P KG+GY++L+ LT+ +L+ + F + PEISFNYLGQF ++ Sbjct: 3429 DLPYQIKQTKENLRRIPKKGIGYEILRTLTTSQLQPPLAFTLRPEISFNYLGQFESDGKT 3488 Query: 3453 GTFEICNTFMESTESPESHRPYAIDINAMIVGNRVEIRVDYNPGQFNEATMSRFAELLLN 3512 G F SPES R + +DI+AMI + I V Y+ Q+ E T++ A+ Sbjct: 3489 GGFTFSPLGTGQLFSPESERVFLLDISAMIEDGELRISVGYSRLQYEEKTIASLADSYRK 3548 Query: 3513 SLKLIISHCTREERIQRSPSDLTYKKLTFEELDDL 3547 L II HC +E + +PSDL ++L+ EEL+++ Sbjct: 3549 HLLGIIEHCMAKEEGEYTPSDLGDEELSMEELENI 3583 Score = 925 bits (2390), Expect = 0.0, Method: Compositional matrix adjust. Identities = 542/1531 (35%), Positives = 823/1531 (53%), Gaps = 67/1531 (4%) Query: 1801 ILDKDMHPSPVGVPGEVYLA-------RLTEPSLLAE-------QPSTS---TGIMAMYT 1843 ILD+ + P G+ GE+Y++ L +P L AE QP TG +A++ Sbjct: 793 ILDEGLQLKPEGIVGELYISGANVGRGYLHQPELTAEKFLDNPYQPGERMYRTGDLALWL 852 Query: 1844 ADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAYI 1903 D +++ +G + G I L I+ +L+ HP I A V + T + + AY+ Sbjct: 853 PDGQLEFLGRIDHQVKIRGHRIELGEIESRLLNHPAIKEAVVIDRADET--GGKFLCAYV 910 Query: 1904 TPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALRE 1963 + + E++ +L +P IPS F+ L+ IP+ G + R LP + + Sbjct: 911 VLQKALSDE--EMRAYLAQALPEYMIPSFFVTLERIPVTPNGKTDRRALPKPEGSAKTKA 968 Query: 1964 EIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDISLR 2023 + + P E E++L IW +L + + D FF LGG+SLKA L IQKE D+ LR Sbjct: 969 DYVAPTTELEQKLVAIWEQILGVSPIGIQDHFFTLGGHSLKAIQLISRIQKECQADVPLR 1028 Query: 2024 MLFEHPTVKGLAKAINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGGAGTAYNIT 2083 +LFE PT++ LA + G +S I + +YP SS+QKR+ + Q+ T YN+ Sbjct: 1029 VLFEQPTIQALAAYVEGGEESAYLAIPQAEPQAYYPVSSAQKRMLILNQLDPHSTVYNLP 1088 Query: 2084 GILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSISYSIAEDED 2143 + +EG LD R+E A LV RHE LRTSF ++ EPV IH+ I Y +E Sbjct: 1089 VAMILEGTLDKARLEHAISNLVARHESLRTSFHTINGEPVSRIHEQGHLPIVYLETAEEQ 1148 Query: 2144 EPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGISANILCNDLISLYS 2203 E++ F+ PF L APL RV +V +++ H++I+DMHHII+DG+S+ ++ ND LY Sbjct: 1149 VNEVILGFMQPFDLVTAPLCRVGLVKLAENRHVLIIDMHHIISDGVSSQLILNDFSRLYQ 1208 Query: 2204 GENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFD 2263 + LP + YKD+ ++Q +YW + +IP L LP+D+PRP VQSF+ Sbjct: 1209 NKALPEQRIHYKDFAVWEKAWTQTTDYQKQEKYWLDRFAGEIPVLNLPMDYPRPAVQSFE 1268 Query: 2264 GACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNY 2323 G Y + L L+ ++ + TTLY +LLA+Y++LLSKYS Q+D++IG+ AGR + Sbjct: 1269 GERYLFRTEKQLLESLQDVAQKTGTTLYMVLLAAYHVLLSKYSGQDDVMIGTVTAGRVHP 1328 Query: 2324 STNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERDI 2383 T +M GMFVNTLAMRNQ A KTF++FLLEVK+NTL AFE+ YPFEEL+ KL I+R+ Sbjct: 1329 DTESMTGMFVNTLAMRNQSAPTKTFRQFLLEVKDNTLAAFEHGQYPFEELVEKLAIQRNR 1388 Query: 2384 SRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKFDLILEVIENTENLTLNFEY 2443 SRNP+FD +F+LQ++D + + LD + + Y + +VAKFDL LE EN L+ FE+ Sbjct: 1389 SRNPLFDTLFILQNMDADL--IELDGLTVTPYVPEGEVAKFDLSLEASENQAGLSFCFEF 1446 Query: 2444 CAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGG 2503 C KLF TI RMS +L+IL V N L+ I++L E L+ FNDTA YP Sbjct: 1447 CTKLFARETIERMSLHYLQILQAVSANTEQELAQIEMLTAHEKQELLVHFNDTAALYPAE 1506 Query: 2504 KTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEH 2563 T+ QLFE+QA +TP A+V + +TY N + NQ+A LR+KGV+ + +VGI+ + Sbjct: 1507 STLSQLFEDQAQKTPEQTAVVFGDKRLTYRELNERANQLAHTLRAKGVQAEQSVGIMAQR 1566 Query: 2564 SFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEFID 2623 S E+ I + A++KAGGAYVPIDP YP+ERI ++++D ++LT + LAEK E + Sbjct: 1567 SLEMAIGIIAILKAGGAYVPIDPDYPNERIAYMLEDCR-RLVLTQQQLAEKMTANVECLY 1625 Query: 2624 AASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYVHG 2683 Y N +++ DLAYIIYTSG+TG PKGVM H+G+ N V W + Sbjct: 1626 LDEEGSYSPQTENIEPIHTAADLAYIIYTSGTTGRPKGVMVEHRGIVNSVTWNRDEFALS 1685 Query: 2684 EAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSGVSYES--LLEAVVIDNQVDFIMLTP 2741 L S AFD + ++SG+ V + + L ++ + +++ P Sbjct: 1686 VRDSGTLSLSFAFDAFALTFFTLIVSGSTVVLMPDHEAKDPIALRNLIAAWECSYVVFVP 1745 Query: 2742 SHLKILGEYDLSR--LKIRKFIIGGEAFDPFYAKKFFSRLAEDVEVYNVYGPTETTVACT 2799 S + + E I+ ++GGE P + + + V N YGPTE++V T Sbjct: 1746 SMFQAILECSTPADIRSIQAVMLGGEKLSPKLV-QLCKAMHPQMSVMNAYGPTESSVMAT 1804 Query: 2800 FYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREEL 2859 + R D P+ IG PI N +Y+VDQ+ +L +G+ GE+CI G G++RGY + EL Sbjct: 1805 YLR---DTQPDQPITIGRPIANTAIYIVDQHHQLLPVGVVGEICIGGHGLARGYWKKPEL 1861 Query: 2860 TREKFVPDPFQTSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQ 2919 T EKFV +P MY+TGDL R L DG ++F+GR+DDQ+K+RG+RIE+GEIE L+ Sbjct: 1862 TAEKFVANPAVPGERMYKTGDLGRWLHDGTIDFIGRVDDQIKVRGYRIEVGEIEAVLLAY 1921 Query: 2920 PGVNKAAVIISTGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFVQMKSIPL 2979 N+A V+ YL AY T + P +MVP++ +Q+ + PL Sbjct: 1922 DQTNEAIVVAYQDDRGDSYLAAYVTGKTAIEESELRAHLLRELPAYMVPTYLIQLDAFPL 1981 Query: 2980 TASGKVDRKKLPDSFESFQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNSFIKLGGD 3039 T +GKVDRK LP AY AP +E KL +WE LGI+ VG + F +LGG Sbjct: 1982 TPNGKVDRKALPKPEGKPATGAAYVAPATEVEAKLVAIWENALGISGVGVLDHFFELGGH 2041 Query: 3040 SIKAIQIVSRL-KKYGLSLEVKELFLHQNIKGISPFVKQNIKRHNQGTIEGPVKLTAIQK 3098 S+KA+ +V+++ +++ + L +K+ F I+ ++ ++ H++ ++ Q Sbjct: 2042 SLKAMTVVAQVHREFQIDLLLKQFFAAPTIRDLARLIE-----HSEQAAGAAIQPAEPQA 2096 Query: 3099 WF----FEQNFAEMHHWNQS--------ILLHNERFDVQFIRQAFQRITEHHDALRMVYR 3146 ++ +Q +H + I++ + D + + A Q + + HD LR + Sbjct: 2097 YYPVSSAQQRMYLLHQLEGAGISYNTPGIIMLEGKLDREQLANALQALVDRHDILRTSFE 2156 Query: 3147 HTGQAGVEQSNRGLAGELFSLEVTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGLY 3206 G V++ + +A + + + DL HA ++ DL PLL++ L Sbjct: 2157 MVGDELVQKIHDRVAVNMEYVTAEE----QQIDDLFHAFVRP----FDLSVPPLLRMSLV 2208 Query: 3207 QTTNGDYLAIV-IHHLVVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALE 3265 + + +L + +HH+ D S I+ D+ A Y G E L E Y+ +A + Sbjct: 2209 KLADERHLLLYDMHHIAADAASITILFDELAELY----QGRE--LPEMRIQYKDFAVWQK 2262 Query: 3266 VYANSPKLLQELAYW--TDVNRIAVPALPKD 3294 S Q+ AYW T I +P D Sbjct: 2263 ALHESDAFKQQEAYWLSTFAGNITAVDVPTD 2293 Score = 545 bits (1405), Expect = e-153, Method: Compositional matrix adjust. Identities = 388/1254 (30%), Positives = 642/1254 (51%), Gaps = 81/1254 (6%) Query: 2086 LHVEGKLDPGRMEEAFQRLVKRHEPLRTSF--ELLHDEPVQVIHDDIPFSISYSIAEDED 2143 + ++G LD G ++ LV+R++ RT F E L +P+QV+ P I + D Sbjct: 41 ISLQGDLDVGLFTDSLHVLVERYDVFRTLFLYEKL-KQPLQVVLKQRPIPIEFYDLSACD 99 Query: 2144 EPELVKRFI--------LPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGISANILC 2195 E E R+ F L + PL RV + S H++ VI HHI+ DG +I+ Sbjct: 100 ESEKQLRYTQYKRADQERTFHLAKDPLMRVALFQMSQHDYQVIWSFHHILMDGWCFSIIF 159 Query: 2196 NDLISLY-SGENLPGLEVQ-YKDYTALHNEMLSNERIRQQGEYWQQLLSDDIPSLTLPLD 2253 +DL+++Y S +N L ++ + Y+ N L + + YW L TLP Sbjct: 160 DDLLAIYLSLQNKTALSLEPVQPYSRFIN-WLEKQNKQAALNYWSDYLEAYEQKTTLPKK 218 Query: 2254 FPRPPVQSFDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYSNQEDIVI 2313 ++F Y +L+ LT+ L ++++ + TL T++ + +LL KY+ D++ Sbjct: 219 -EAAFAKAFQPTQYRFSLNRTLTKQLGTIASQNQVTLSTVIQTIWGVLLQKYNAAHDVLF 277 Query: 2314 GSPVAGRFN--YSTNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFE 2371 GS V+GR + MVG+F+NT+ R Q +TF E L V + TL++ + P Sbjct: 278 GSVVSGRPTDIVGIDKMVGLFINTIPFRVQAKAGQTFSELLQAVHKRTLQSQPYEHVPLY 337 Query: 2372 ELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLDDIRLN---GYEFKN----DVAKF 2424 ++ ++ + + + D + V+++ L L LN G+ + + Sbjct: 338 DIQTQ-----SVLKQELIDHLLVIENYPLVEA---LQKKALNQQIGFTITAVEMFEPTNY 389 Query: 2425 DLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKE 2484 DL + V+ E L F+Y A LF E + +++ +I V N V L I LL + Sbjct: 390 DLTVMVMPK-EELAFRFDYNAALFDEQVVQKLAGHLQQIADCVANNSGVELCQIPLLTEA 448 Query: 2485 ETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMAR 2544 ET +L+ +TA YP T+++LF QA +TP VA+V + +TY + K+NQ+AR Sbjct: 449 ETSQLLAKRTETAADYPAA-TMHELFSRQAEKTPEQVAVVFADQHLTYRELDEKSNQLAR 507 Query: 2545 MLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEI 2604 LR KG+ + VG L++ S ++I+ + V+KAGGA+VPIDP P+ERI +++ S + + Sbjct: 508 FLRKKGIGTGSLVGTLLDRSLDMIVGILGVLKAGGAFVPIDPELPAERIAYMLTHSRVPL 567 Query: 2605 MLTHKGLAEKCQFQGEFIDAASSKWYCGDDSN-PV-SVNSPDDLAYIIYTSGSTGLPKGV 2662 ++T L K E ID ++ G++S P+ S+N P DL YIIYTSG+TG PKGV Sbjct: 568 VVTQNHLRAKVTTPTETIDINTA--VIGEESRAPIESLNQPHDLFYIIYTSGTTGQPKGV 625 Query: 2663 MTRHQGLTNYVWWG-DKTYV--HGEAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSG- 2718 M H+ + N + + D+T + H + + Y++ +FD+ I+ L+SG ++++ + Sbjct: 626 MLEHRNMANLMHFTFDQTNIAFHEKVLQ---YTTCSFDVCYQEIFSTLLSGGQLYLITNE 682 Query: 2719 -VSYESLLEAVVIDNQVDFIMLTPSHLK-ILGEYDLSR---LKIRKFIIGGEAFDPFYAK 2773 + L A + + Q+ + L S LK I E D ++ ++ I GE + Sbjct: 683 LRRHVEKLFAFIQEKQISILSLPVSFLKFIFNEQDYAQSFPRCVKHIITAGEQLVVTHEL 742 Query: 2774 KFFSRLAEDVEVYNVYGPTETTV--ACTFYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNG 2831 + + R V ++N YGP+ET V CT P + + PIG PI N +Y++D+ Sbjct: 743 QKYLR-QHRVFLHNHYGPSETHVVTTCTMD---PGQAIPELPPIGKPISNTGIYILDEGL 798 Query: 2832 KLQGIGIPGELCIAGDGVSRGYLNREELTREKFVPDPFQTSGMMYRTGDLVRMLQDGNVE 2891 +L+ GI GEL I+G V RGYL++ ELT EKF+ +P+Q MYRTGDL L DG +E Sbjct: 799 QLKPEGIVGELYISGANVGRGYLHQPELTAEKFLDNPYQPGERMYRTGDLALWLPDGQLE 858 Query: 2892 FLGRMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTADFPMNX 2951 FLGR+D QVKIRGHRIELGEIE++L+ P + +A VI T ++LCAY ++ Sbjct: 859 FLGRIDHQVKIRGHRIELGEIESRLLNHPAIKEAVVIDRADETGGKFLCAYVVLQKALSD 918 Query: 2952 XXXXXXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIE 3011 P +M+PSFFV ++ IP+T +GK DR+ LP S + + Y AP +E Sbjct: 919 EEMRAYLAQALPEYMIPSFFVTLERIPVTPNGKTDRRALPKPEGSAKTKADYVAPTTELE 978 Query: 3012 EKLALVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRLKKYGLS-LEVKELFLHQNIKG 3070 +KL +WE++LG++ +G + F LGG S+KAIQ++SR++K + + ++ LF I+ Sbjct: 979 QKLVAIWEQILGVSPIGIQDHFFTLGGHSLKAIQLISRIQKECQADVPLRVLFEQPTIQA 1038 Query: 3071 ISPFVKQNIKRH----NQGTIEGPVKLTAIQKWFFEQNFAEMHH--WNQSILLHNE-RFD 3123 ++ +V+ + Q + +++ QK N + H +N + + E D Sbjct: 1039 LAAYVEGGEESAYLAIPQAEPQAYYPVSSAQKRMLILNQLDPHSTVYNLPVAMILEGTLD 1098 Query: 3124 VQFIRQAFQRITEHHDALRMVYRHTGQAGVEQSNRGLAGELFSLEVTDLTGCDDHTDLMH 3183 + A + H++LR + V + + E L + L ++ + + Sbjct: 1099 KARLEHAISNLVARHESLRTSFHTINGEPVSRIH-----EQGHLPIVYLETAEEQVNEVI 1153 Query: 3184 AGIKTIQKGIDLEKGPLLKLGLYQTTNGDYLAIV-IHHLVVDGVSWRIILDDFASCYLSL 3242 G + DL PL ++GL + ++ I+ +HH++ DGVS ++IL+DF+ Y Sbjct: 1154 LG---FMQPFDLVTAPLCRVGLVKLAENRHVLIIDMHHIISDGVSSQLILNDFSRLY--- 1207 Query: 3243 DNGEEAGLIEKSDSYQKWAEALEVYANSPKLLQELAYWTD--VNRIAVPALPKD 3294 + L E+ Y+ +A + + + ++ YW D I V LP D Sbjct: 1208 ---QNKALPEQRIHYKDFAVWEKAWTQTTDYQKQEKYWLDRFAGEIPVLNLPMD 1258 Score = 330 bits (846), Expect = 5e-88, Method: Compositional matrix adjust. Identities = 173/447 (38%), Positives = 266/447 (59%), Gaps = 7/447 (1%) Query: 3555 ITDVYTMTPMQESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRT 3614 + D+Y +TPMQE MLFHAL ++ +++ Q + L+GD+ L +S ++V +YD+ RT Sbjct: 9 VQDMYALTPMQEGMLFHALLDQEHNSHLVQMSISLQGDLDVGLFTDSLHVLVERYDVFRT 68 Query: 3615 RFVYKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGPLMR 3674 F+Y+KL +PLQ+VL +EF D++ + SEK + K D+E+ F L + PLMR Sbjct: 69 LFLYEKLKQPLQVVLKQRPIPIEFYDLSACDESEKQLRYTQYKRADQERTFHLAKDPLMR 128 Query: 3675 AILLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSLETHQ-YRLYLD 3733 L + YQ++WSFHHILMDGWC I+ D+L Y L + SLE Q Y +++ Sbjct: 129 VALFQMSQHDYQVIWSFHHILMDGWCFSIIFDDLLAIYLSLQNKTALSLEPVQPYSRFIN 188 Query: 3734 WLASKNKEEAKVYWMQYLEDYKYKELL-RKEGT-SKEFRLAVLDIKLEEKVRTAVTHVAS 3791 WL +NK+ A YW YLE Y+ K L +KE +K F+ L + + +AS Sbjct: 189 WLEKQNKQAALNYWSDYLEAYEQKTTLPKKEAAFAKAFQPTQYRFSLNRTLTKQLGTIAS 248 Query: 3792 SSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGRSPEIEGIERMVGLFINTIPVRVRL 3851 + +T+++ Q +WG+LL KY+ A DV+FG+V+SGR +I GI++MVGLFINTIP RV+ Sbjct: 249 QNQVTLSTVIQTIWGVLLQKYNAAHDVLFGSVVSGRPTDIVGIDKMVGLFINTIPFRVQA 308 Query: 3852 -SGKTFHELAGEIQSSFISSEQYGYVPLSDIQAWS--HRDLINHVMVFENYPLDREIRDT 3908 +G+TF EL + + S+ Y +VPL DIQ S ++LI+H++V ENYPL ++ Sbjct: 309 KAGQTFSELLQAVHKRTLQSQPYEHVPLYDIQTQSVLKQELIDHLLVIENYPLVEALQKK 368 Query: 3909 DGQQMEYGFQIAGCEILEHTNYDFSIIIEPGEDFIIRIVYNALAYDKETISILESYLLAI 3968 Q + GF I E+ E TNYD ++++ P E+ R YNA +D++ + L +L I Sbjct: 369 ALNQ-QIGFTITAVEMFEPTNYDLTVMVMPKEELAFRFDYNAALFDEQVVQKLAGHLQQI 427 Query: 3969 IGQVTACPQIEAGDVEVLSQEEKLKLM 3995 V +E + +L++ E +L+ Sbjct: 428 ADCVANNSGVELCQIPLLTEAETSQLL 454 Score = 155 bits (391), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 114/425 (26%), Positives = 192/425 (45%), Gaps = 16/425 (3%) Query: 1329 PQVLKLTEEQQQISLVIHSNDTHGVVHHETVGLYLRGELNKAALETAYHKVLNRHESLRS 1388 PQ Q+ L+++ D H V++ V + L G L+KA LE A ++ RHESLR+ Sbjct: 1059 PQAYYPVSSAQKRMLILNQLDPHSTVYNLPVAMILEGTLDKARLEHAISNLVARHESLRT 1118 Query: 1389 TISADGNEQIVASHANADIFFADILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRV 1448 + E + H + Y +E +N+ +L FD V PL R+ + Sbjct: 1119 SFHTINGEPVSRIHEQGHLPIV-----YLETAEEQVNEVILG-FMQPFDLVTAPLCRVGL 1172 Query: 1449 LATARHEYLLALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQK 1508 + A + ++L + HHII+DG S + L + + LY + + + + D+A+W+K Sbjct: 1173 VKLAENRHVLIIDMHHIISDGVSSQLILNDFSRLYQNKALPEQRI-----HYKDFAVWEK 1227 Query: 1509 RMLESQPKEKAAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYVLDIPLTAKLKAV 1568 ++ +K YW ++F+ + P LP R A +G R+ + + L L+ V Sbjct: 1228 AWTQTTDYQKQEKYWLDRFAGEIPVLNLPMDYPRPAVQSFEGERYLFRTEKQLLESLQDV 1287 Query: 1569 SQSMKVSLFTVLLSAYKVLLYRISNHKELVVGIPTAGQMQMGQKHLVGYCLNILPFSTTI 1628 +Q +L+ VLL+AY VLL + S ++++G TAG++ + + G +N L Sbjct: 1288 AQKTGTTLYMVLLAAYHVLLSKYSGQDDVMIGTVTAGRVHPDTESMTGMFVNTLAMRNQS 1347 Query: 1629 NPEMTFRXXXXXXXXXXXXXXXXQDYSYASLMKELHSLDGSVHPPQINTMF---NMDKSL 1685 P TFR Y + L+++L P +T+F NMD L Sbjct: 1348 APTKTFRQFLLEVKDNTLAAFEHGQYPFEELVEKLAIQRNRSRNPLFDTLFILQNMDADL 1407 Query: 1686 ETPDFTGMDVELLQSPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQIITGWANYFNR 1745 D G+ V +K+DLS+ E L FE+ LF + I + ++ + Sbjct: 1408 IELD--GLTVTPYVPEGEVAKFDLSLEASENQAGLSFCFEFCTKLFARETIERMSLHYLQ 1465 Query: 1746 ILLAV 1750 IL AV Sbjct: 1466 ILQAV 1470 Score = 151 bits (381), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 111/429 (25%), Positives = 193/429 (44%), Gaps = 22/429 (5%) Query: 1329 PQVLKLTEEQQQISLVIHSNDTHGVVHHETVGLYLRGELNKAALETAYHKVLNRHESLRS 1388 PQ QQ ++H + G+ ++ + L G+L++ L A +++RH+ LR+ Sbjct: 2094 PQAYYPVSSAQQRMYLLHQLEGAGISYNTPGIIMLEGKLDREQLANALQALVDRHDILRT 2153 Query: 1389 TISADGNEQIVASHANADIFFADILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRV 1448 + G+E + H + + A+ + D L FD + PL+R+ + Sbjct: 2154 SFEMVGDELVQKIHDRVAVNMEYVTAEEQQIDD------LFHAFVRPFDLSVPPLLRMSL 2207 Query: 1449 LATARHEYLLALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQK 1508 + A +LL HHI AD S+ + ELA LY R L + D+A+WQK Sbjct: 2208 VKLADERHLLLYDMHHIAADAASITILFDELAELYQG-----RELPEMRIQYKDFAVWQK 2262 Query: 1509 RMLESQPKEKAAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYVLDIPLTAKLKAV 1568 + ES ++ AYW + F+ A ++P+ R A G + +D L + L + Sbjct: 2263 ALHESDAFKQQEAYWLSTFAGNITAVDVPTDFPRPAVKSFAGGQVTLSMDQELLSALHEL 2322 Query: 1569 SQSMKVSLFTVLLSAYKVLLYRISNHKELVVGIPTAGQMQMGQKHLVGYCLNILPFSTTI 1628 + +LF VLL+AY VLL + + +++VG P +G+ + +VG ++ L Sbjct: 2323 AAHTNTTLFMVLLAAYNVLLAKYAGQDDIIVGTPISGRSRAELAPVVGMFVHTLAIRNKP 2382 Query: 1629 NPEMTFRXXXXXXXXXXXXXXXXQDYSYASLMKELHSLDGSVHPPQINTMFNMDKSLETP 1688 E TF+ QDY + SL+++L G P N +F+ L+ Sbjct: 2383 TAEKTFKQFLQEVKQNALDAFDHQDYPFESLVEKL----GIPRDPGRNPLFDTMFILQND 2438 Query: 1689 DFTGMDVELL-------QSPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQIITGWAN 1741 + ++ L S + +K+DLS ++ E + +L + EY LF Q + A+ Sbjct: 2439 ELHAKTLDQLVYRPYESDSALDVAKFDLSFHLTERETDLFLRLEYCTKLFKQQTVERMAH 2498 Query: 1742 YFNRILLAV 1750 +F +IL AV Sbjct: 2499 HFLQILRAV 2507 Score = 107 bits (268), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 111/480 (23%), Positives = 220/480 (45%), Gaps = 64/480 (13%) Query: 3559 YTMTPMQESM-LFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRF- 3616 Y ++ Q+ M L H L+ +Y+ I+ L+G + +E L + + +V ++DILRT F Sbjct: 2098 YPVSSAQQRMYLLHQLEGA-GISYNTPGIIMLEGKLDREQLANALQALVDRHDILRTSFE 2156 Query: 3617 -----VYKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGP 3671 + +K+H + + ++E+ ++E+ + A R FDL P Sbjct: 2157 MVGDELVQKIHDRVAV-------NMEYV------TAEEQQIDDLFHAFVRP--FDLSVPP 2201 Query: 3672 LMRAILLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSLETHQYRLY 3731 L+R L+K D + +L+ HHI D I I+ ++ E Y+ P + QY+ + Sbjct: 2202 LLRMSLVKLADERHLLLYDMHHIAADAASITILFDELAELYQ---GRELPEMRI-QYKDF 2257 Query: 3732 LDWLASKNKEEA----KVYWMQYLE----------DYKYKELLRKEGTSKEFRLAVLDIK 3777 W + ++ +A + YW+ D+ + K F + + Sbjct: 2258 AVWQKALHESDAFKQQEAYWLSTFAGNITAVDVPTDFPRPAV-------KSFAGGQVTLS 2310 Query: 3778 LEEKVRTAVTHVASSSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGRSPEIEGIERM 3837 +++++ +A+ +A+ + T+ A + +LL+KY +D++ G ISGRS + + Sbjct: 2311 MDQELLSALHELAAHTNTTLFMVLLAAYNVLLAKYAGQDDIIVGTPISGRSRA--ELAPV 2368 Query: 3838 VGLFINTIPVRVRLSG-KTFHELAGEIQSSFISSEQYGYVPLSDI--QAWSHRD-----L 3889 VG+F++T+ +R + + KTF + E++ + + + + P + + RD L Sbjct: 2369 VGMFVHTLAIRNKPTAEKTFKQFLQEVKQNALDAFDHQDYPFESLVEKLGIPRDPGRNPL 2428 Query: 3890 INHVMVFENYPLDREIRDTDGQQMEYGFQIAGCEILEHTNYDFSI-IIEPGEDFIIRIVY 3948 + + + +N L + D Q+ Y L+ +D S + E D +R+ Y Sbjct: 2429 FDTMFILQNDELHAKTLD----QLVYR-PYESDSALDVAKFDLSFHLTERETDLFLRLEY 2483 Query: 3949 NALAYDKETISILESYLLAIIGQVTACPQIEAGDVEVLSQEEKLKLMNVFNKPNRREAAD 4008 + ++T+ + + L I+ VTA P+ E ++E+L+ EK L+ FN +R AD Sbjct: 2484 CTKLFKQQTVERMAHHFLQILRAVTANPENELQEIEMLTAAEKQMLLVAFNDTHREYRAD 2543 Score = 99.0 bits (245), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 107/477 (22%), Positives = 209/477 (43%), Gaps = 78/477 (16%) Query: 3559 YTMTPMQESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRF-- 3616 Y ++ Q+ ML + S Y+ + L+G + + L + +V +++ LRT F Sbjct: 1063 YPVSSAQKRMLILNQLDPHSTVYNLPVAMILEGTLDKARLEHAISNLVARHESLRTSFHT 1122 Query: 3617 --------VYKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLV 3668 ++++ H P I ++E++E+ + L + + FDLV Sbjct: 1123 INGEPVSRIHEQGHLP----------------IVYLETAEEQVNEVILGFM---QPFDLV 1163 Query: 3669 QGPLMRAILLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSLETHQY 3728 PL R L+K ++ + ++ HHI+ DG ++L D Y+ + P H Y Sbjct: 1164 TAPLCRVGLVKLAENRHVLIIDMHHIISDGVSSQLILNDFSRLYQN---KALPEQRIH-Y 1219 Query: 3729 RLYL----DWLASKNKEEAKVYWMQYLE----------DYKYKELLRKEGTSKEFRLAVL 3774 + + W + + ++ + YW+ DY + EG FR Sbjct: 1220 KDFAVWEKAWTQTTDYQKQEKYWLDRFAGEIPVLNLPMDYPRPAVQSFEGERYLFRT--- 1276 Query: 3775 DIKLEEKVRTAVTHVASSSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGR-SPEIEG 3833 E+++ ++ VA +G T+ A + +LLSKY +DV+ G V +GR P+ E Sbjct: 1277 ----EKQLLESLQDVAQKTGTTLYMVLLAAYHVLLSKYSGQDDVMIGTVTAGRVHPDTES 1332 Query: 3834 IERMVGLFINTIPVRVRLS-GKTFHELAGEIQSSFISSEQYGYVPLSDI-------QAWS 3885 M G+F+NT+ +R + + KTF + E++ + +++ ++G P ++ + S Sbjct: 1333 ---MTGMFVNTLAMRNQSAPTKTFRQFLLEVKDNTLAAFEHGQYPFEELVEKLAIQRNRS 1389 Query: 3886 HRDLINHVMVFENYPLDREIRDTDGQQMEYGFQIAGCEILEHTNYDFSIII---EPGEDF 3942 L + + + +N +D ++ + DG + + E+ +D S+ + G F Sbjct: 1390 RNPLFDTLFILQN--MDADLIELDG--LTVTPYVPEGEV---AKFDLSLEASENQAGLSF 1442 Query: 3943 IIRIVYNALAYDKETISILESYLLAIIGQVTACPQIEAGDVEVLSQEEKLKLMNVFN 3999 A +ETI + + L I+ V+A + E +E+L+ EK +L+ FN Sbjct: 1443 CFEFCTKLFA--RETIERMSLHYLQILQAVSANTEQELAQIEMLTAHEKQELLVHFN 1497 Score = 92.4 bits (228), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 92/407 (22%), Positives = 176/407 (43%), Gaps = 29/407 (7%) Query: 1355 HHETVGLYLRGELNKAALETAYHKVLNRHESLRSTISADGNEQ---IVASHANADIFFAD 1411 H + + L+G+L+ + H ++ R++ R+ + +Q +V I F D Sbjct: 35 HLVQMSISLQGDLDVGLFTDSLHVLVERYDVFRTLFLYEKLKQPLQVVLKQRPIPIEFYD 94 Query: 1412 ILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIADGWS 1471 + A + Q + F PL+R+ + ++H+Y + S HHI+ DGW Sbjct: 95 LSACDESEKQLRYTQYKRADQERTFHLAKDPLMRVALFQMSQHDYQVIWSFHHILMDGWC 154 Query: 1472 LIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQPKEKAAAYWKNKFSVQT 1531 + +L A+Y + T L P+S + W LE Q K+ A YW + Sbjct: 155 FSIIFDDLLAIYLSLQNKTALSLEPVQPYSRFINW----LEKQNKQAALNYWSDYLEAYE 210 Query: 1532 PAFELPSFRIRDAAGVR--KGSRHRYVLDIPLTAKLKAVSQSMKVSLFTVLLSAYKVLLY 1589 LP ++AA + + +++R+ L+ LT +L ++ +V+L TV+ + + VLL Sbjct: 211 QKTTLPK---KEAAFAKAFQPTQYRFSLNRTLTKQLGTIASQNQVTLSTVIQTIWGVLLQ 267 Query: 1590 RISNHKELVVGIPTAGQMQ--MGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXXXX 1647 + + +++ G +G+ +G +VG +N +PF TF Sbjct: 268 KYNAAHDVLFGSVVSGRPTDIVGIDKMVGLFINTIPFRVQAKAGQTFSELLQAVHKRTLQ 327 Query: 1648 XXXXQ-----DYSYASLMKE--LHSLDGSVHPPQINTMFNMDKSL-ETPDFTGMDVELLQ 1699 + D S++K+ + L + P + + K+L + FT VE+ + Sbjct: 328 SQPYEHVPLYDIQTQSVLKQELIDHLLVIENYPLVEAL--QKKALNQQIGFTITAVEMFE 385 Query: 1700 SPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQIITGWANYFNRI 1746 + YDL++ ++ EL F+Y+ LFD Q++ A + +I Sbjct: 386 P----TNYDLTVMVMP-KEELAFRFDYNAALFDEQVVQKLAGHLQQI 427 >dbj|BAB69699.1| iturin A synthetase B [Bacillus subtilis] Length = 5362 Score = 1302 bits (3369), Expect = 0.0, Method: Compositional matrix adjust. Identities = 717/1987 (36%), Positives = 1119/1987 (56%), Gaps = 46/1987 (2%) Query: 2043 KSFLPEITPLGK-KDWYPQSSSQKRLFAIEQMGGAGTAYNITGILHVEGKLDPGRMEEAF 2101 + L + LG+ ++ YP + QK + AY + + G L+ ++ Sbjct: 1303 EQLLEQTRELGEAENIYPLTPMQKGMLFHSLFDPNSGAYFQQTMFDLHGDLEIDSFSKSL 1362 Query: 2102 QRLVKRHEPLRTSF-ELLHDEPVQVIHDDIPFSISYSIAEDEDEPE---LVKRF-----I 2152 L ++++ RT+F D+P+Q+I ++ + E + +++++ + Sbjct: 1363 DGLSQKYDIFRTNFYRGWKDQPLQIIFKTKKIGFQFNDLREMKESQKEAMIQQYAREDKM 1422 Query: 2153 LPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADG-----ISANILCNDLISLYSGENL 2207 F L + L R+ I+ + + I HHI+ DG I+ I N L + Sbjct: 1423 RGFDLEKGALMRLFILRTDEKTYRFIWSFHHILMDGWCLPLITKEIFENYFALLQQKQPE 1482 Query: 2208 PGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFDGACY 2267 Y Y E L + ++ YW Q L LP D + Sbjct: 1483 QSSITPYSQYI----EWLGRQDAKEATAYWDQYLEGYEEQTGLPKDHHAAEDGRYVPEKV 1538 Query: 2268 SVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNYSTN- 2326 + + SDLT +K + + TL TLL ++ +LL KY+ D+V GS V+GR N Sbjct: 1539 TCDISSDLTSKMKRTAGKHHVTLNTLLQTAWAVLLQKYNRSRDVVFGSVVSGRPAGIPNV 1598 Query: 2327 -NMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERD-IS 2384 M+G+F+NT+ +R + TF + E +E + + + + +P ++ ++ ++D I+ Sbjct: 1599 ETMIGLFINTIPVRFRCEAGTTFAGLMKEAQERAVASQQFETHPLYDIQARTTQKQDLIT 1658 Query: 2385 RNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKFDLILEVIENTENLTLNFEYC 2444 +F+ V Q ++ ++ + I ++ + + +D L VI E + ++FEY Sbjct: 1659 HLMIFENYPVDQYME-SIGRQNGTSITISNVQMEEQT-NYDFNLTVIPGDE-MNISFEYN 1715 Query: 2445 AKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGGK 2504 A +++ ++I R+ E F++IL VV + ++ + +LL + E L+ T NDTA +P Sbjct: 1716 ANVYERASIERVREHFMQILHQVVTDADIRVDQAELLTEGERRTLLQTLNDTAAPFPQ-T 1774 Query: 2505 TVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEHS 2564 V+QLFEEQ+ RTP A++ + +TY N++ N++AR LR+KGV+ D V I+ +S Sbjct: 1775 PVHQLFEEQSQRTPDQAAVIDKDRQLTYGELNKRANRLARTLRAKGVQTDQPVAIITRNS 1834 Query: 2565 FELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEFIDA 2624 E ++ + AV+K+GGAYVPIDP YP +RI +++ DS I+L + + ++ ++G + Sbjct: 1835 IESVVGILAVLKSGGAYVPIDPEYPQDRIRYMLDDSQAGIVLMQQDVRKQLAYEGVTVLL 1894 Query: 2625 ASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYVHGE 2684 Y D S+ +N LAY+IYTSGSTG PKGV+ H GLTNY+WW + YV GE Sbjct: 1895 DDESSYHQDGSDLAPINDVSHLAYVIYTSGSTGRPKGVLIEHGGLTNYIWWAKEVYVKGE 1954 Query: 2685 AVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSGVSYESLLEAVVIDNQVDFIMLTPSHL 2744 +FPLYSSI+FDL+VT I+ PL++GN + +Y G +LLE++V D +VD I LTP+HL Sbjct: 1955 KANFPLYSSISFDLTVTSIFTPLVTGNAIIVYDGEDKTALLESIVRDPRVDIIKLTPAHL 2014 Query: 2745 KILGEYDLS-RLKIRKFIIGGEAFDPFYAKKFFSRLAEDVEVYNVYGPTETTVACTFYRY 2803 ++L E +++ ++ +R+ I+GGE A+ + +E+ N YGPTET V C YRY Sbjct: 2015 QVLKEMNIADQMAVRRMIVGGENLSTRLARSIHEQFEGRIEICNEYGPTETVVGCMIYRY 2074 Query: 2804 YPDKDLRNPVPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREELTREK 2863 P KD R VPIG N +YV+D+N K IG+PGE+ I+G GV+RGYLNR ELT EK Sbjct: 2075 DPAKDRRESVPIGTAAANTSIYVLDENMKPAPIGVPGEIYISGAGVARGYLNRPELTAEK 2134 Query: 2864 FVPDPFQTSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQPGVN 2923 FV D F+ MY+TGDL + L DGN+E+ GR+D+QVKIRG+RIELGEIE L+++ + Sbjct: 2135 FVDDLFEPGAKMYKTGDLAKWLADGNIEYAGRIDEQVKIRGYRIELGEIEAALLQEEAIK 2194 Query: 2924 KAAVIISTGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFVQMKSIPLTASG 2983 +A V + LCAYY + +MVP++F+++ +PLT++G Sbjct: 2195 EAVVTAREDVHGFKQLCAYYVSGGQTTAARLRKQLSQTLASYMVPAYFIELDEMPLTSNG 2254 Query: 2984 KVDRKKLPDSFESFQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNSFIKLGGDSIKA 3043 K++RK LP Q Y AP+ EE L WE VLG V ++F LGGDSIK+ Sbjct: 2255 KINRKGLPAPNFELQDRAEYKAPRTKAEEILVSAWESVLGAENVSILDNFFDLGGDSIKS 2314 Query: 3044 IQIVSRLKKYGLSLEVKELFLHQNIKGISPFVKQNIKRHNQGTIEGPVKLTAIQKWFFEQ 3103 IQ+ SRL + G +E+K+LF + I +SP +KQN++ +QG ++G V LT IQ WFFEQ Sbjct: 2315 IQVSSRLNQQGYKMEIKDLFQYATIAELSPHIKQNLRIADQGEVKGKVSLTPIQHWFFEQ 2374 Query: 3104 NFAEMHHWNQSILLHN-ERFDVQFIRQAFQRITEHHDALRMVYRHTGQAGVEQSNRGLAG 3162 + H++NQ+++LH E F +RQ Q++ EHHDALRM +R T + G E N +A Sbjct: 2375 TTTDQHYYNQAVMLHAPEGFQETQLRQTLQKLAEHHDALRMTFR-TTENGCEAQNEEIAQ 2433 Query: 3163 E-LFSLEVTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGLYQTTNGDYLAIVIHHL 3221 L+ LEV +L D + A IQ + L GPL+K GL+Q NGD+L I IHHL Sbjct: 2434 SGLYRLEVLNLKEDSDPGRTIEAKADEIQSSMRLSDGPLMKAGLFQCANGDHLLIAIHHL 2493 Query: 3222 VVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALEVYANSPKLLQELAYWT 3281 ++DG+SWRI+L+D S Y +N L +K+DS+Q WA+ L YA S + QE YWT Sbjct: 2494 IIDGISWRILLEDIVSGYKQAENVRVIQLPQKTDSFQLWAKRLSEYAQSETIKQEQEYWT 2553 Query: 3282 DVNRIAVPALPKDSEAGNGKIKDRYQTKTVLSEKETTNLLRHAGDAYQTETXXXXXXXXX 3341 + + V LPKD + KD +++ET LL+ A AY TE Sbjct: 2554 KIEQTEVKPLPKDFHETHTTAKDSETATVEWTKEETELLLKQANRAYHTEINDLLLTSLG 2613 Query: 3342 XXIKGWANVDRVRINMEGHGREALIQDLDITRTVGWFTSTYPLVLELANSHELPLHIMTT 3401 I W+ ++++ I++EGHGRE +IQD+DI+RTVGWFTS YP+VL E+ +I TT Sbjct: 2614 LSISHWSGLEQIPIHLEGHGREQIIQDIDISRTVGWFTSLYPVVLHAQPGKEISDYIKTT 2673 Query: 3402 KETIRQTPNKGMGYQVLKYLTSPELRAAVDFNVMPEISFNYLGQFGNEASYGTFEICNTF 3461 KE +RQ P+KG+GY + +YL+ + + PEISFNYLGQF + ++ + Sbjct: 2674 KEGLRQIPHKGIGYGIARYLS-----GGMPSKLNPEISFNYLGQFDQDLQQHGVQLSSYS 2728 Query: 3462 MESTESPESHRPYAIDINAMIVGNRVEIRVDYNPGQFNEATMSRFAELLLNSLKLIISHC 3521 S S RPY ++IN MI R+++ + Y+ Q+ + T+ R +E + + L+ II+HC Sbjct: 2729 CGSDSSENQERPYVLNINGMITEGRLKLTISYSSKQYAKETIMRLSETIQSRLRTIITHC 2788 Query: 3522 TREERIQRSPSDLTYKKLTFEELDDLNRLYP--GGITDVYTMTPMQESMLFHALKNKRSD 3579 +E+ + +PSD+ K ++ ELD L P G + +VY +TPMQ+ MLFH+L ++ S Sbjct: 2789 VHKEQSELTPSDILLKGMSIGELDQLLIQLPHAGEVENVYPLTPMQKGMLFHSLLDEASS 2848 Query: 3580 AYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRFVYKKLHRPLQIVLGSSDFHLEFE 3639 +Y EQ DL+G++ + S + + Y +LRTRF PLQIV + + F Sbjct: 2849 SYFEQASFDLQGELKIDWFKASLERLFETYAVLRTRFYSGWNDTPLQIVYKTQTPQIHFA 2908 Query: 3640 DITHMESSEKMAHMERLKALDREKRFDLVQGPLMRAILLKTGDSVYQMLWSFHHILMDGW 3699 D+ +E + + + D+ K FDL + PLMR + + D Y ++WSFHHI+MDGW Sbjct: 2909 DLRDIEEHLREDAIAAYQREDKAKGFDLARDPLMRIAIFRMEDRKYHLIWSFHHIVMDGW 2968 Query: 3700 CIGIVLKDMLEHYKQLNAGSRPS-LETHQYRLYLDWLASKNKEEAKVYWMQYLEDYKYK- 3757 C+ ++ K++ +HY L G P L Y Y++WL +++ AK YW YLE YK + Sbjct: 2969 CLSLITKEVFDHYSALQEGREPEPLSAVPYSDYIEWLDRQDQGAAKRYWGGYLEGYKGET 3028 Query: 3758 ELLRK--EGTSKEFRLAVLDIKLEEKVRTAVTHVASSSGITINSFFQAVWGILLSKYDNA 3815 LL K + KE+ A L + + + + +A+ +T+N+ Q +WG+LL KY + Sbjct: 3029 TLLHKIAQHEQKEYAYANLICRFDHEQTKQLQQIANQHQVTLNTLIQTLWGVLLQKYSGS 3088 Query: 3816 EDVVFGAVISGRSPEIEGIERMVGLFINTIPVRVRL-SGKTFHELAGEIQSSFISSEQYG 3874 DVVFG+V+SGR EI +E+M+GLFINTIPVR+R TF + +Q + ++S+ Y Sbjct: 3089 ADVVFGSVVSGRPAEIPDVEQMIGLFINTIPVRIRCDEDSTFADTMQMVQQNALASQSYD 3148 Query: 3875 YVPLSDIQAWSH--RDLINHVMVFENYPLDREIRDTDGQQMEYGFQIAGCEILEHTNYDF 3932 PL +IQA + ++LI+H+M+FENYP+ ++ +T E I + EH++YD Sbjct: 3149 TYPLYEIQAQTEQKQNLIDHIMIFENYPIGQQAEETGHHGTE--LNITNFHMQEHSHYDL 3206 Query: 3933 SIIIEPGEDFIIRIVYNALAYDKETISILESYLLAIIGQVTACPQIEAGDVEVLSQEEKL 3992 ++++ PG+ + +N Y+K + L + ++ QV P ++ D+E+LSQ+EK Sbjct: 3207 NVVVIPGKQLAVHFGFNKNEYEKSEVERLRGHFEKLMQQVLRQPSVKIEDLELLSQQEKE 3266 Query: 3993 KLMNVFN 3999 L++ F Sbjct: 3267 YLLSRFQ 3273 Score = 1129 bits (2919), Expect = 0.0, Method: Compositional matrix adjust. Identities = 621/1790 (34%), Positives = 984/1790 (54%), Gaps = 50/1790 (2%) Query: 2231 RQQGEYWQQLLSDDIPSLTLPL----DFPRPPVQSFDGACYSVTLDSDLTRGLKVLSNRL 2286 + Q YW+ L ++ P D + C +L ++++ + ++N Sbjct: 5 KTQETYWENLFDEEDGLSAFPYFKAADKASLARTGYQEKCICRSLSPEVSQRIMTMANHS 64 Query: 2287 KTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNYSTNNMVGMFVNTLAMRNQPAKHK 2346 Y +LLA LL KY+++ +++G P + + + N + ++N + Sbjct: 65 DMAAYLILLAGIECLLYKYTDRTSLILGIPTVSKQKAGQSAVN----NIVLLKNTLSNES 120 Query: 2347 TFQEFLLEVKENTLEAFENQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVH 2406 TF+ ++KE ++ +NQ+ PF +++ L ++ + P+ + V Sbjct: 121 TFKTVFGQLKEAVNDSLKNQNLPFRKMVRHLSVQYNDEHMPLIHTV------------VS 168 Query: 2407 LDDIRLNGYEFKNDVAKFDLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTT 2466 L++I + + K D A L +EN + L Y L+ E I ++ ++L+ Sbjct: 169 LNEI--HSKQCKEDTATDTLFHFDLENN-GIHLKLFYNGNLYDERYINQIVSHLDQLLSV 225 Query: 2467 VVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGAVALVHQ 2526 ++ + ++LP+ E +L++ FNDT + G +TVYQLFEEQA RTP A+ + Sbjct: 226 ILFQPQAAIHTAEILPEAEKQKLLFDFNDTVRDFSGSRTVYQLFEEQAERTPEHAAVKFK 285 Query: 2527 GESITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGAYVPIDP 2586 + +TY N K +++AR LR+ GV+PDT V IL + S E+I+S+ AV KAGGAYVP+DP Sbjct: 286 NDHLTYRELNEKASRLARTLRNCGVQPDTLVAILADRSLEMIVSIIAVWKAGGAYVPLDP 345 Query: 2587 TYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEFIDAASSKWYCGDDSNPVSVNSPDDL 2646 YP ER+ +++ D++ +++L L F G ID Y D S V L Sbjct: 346 EYPKERLQYLLHDADADVLLVQHHLKNSLAFDGPVIDLNDETSYHADCSLLSPVAGHSHL 405 Query: 2647 AYIIYTSGSTGLPKGVMTRHQGLTNYVWWGDKTYVHGEAVDFPLYSSIAFDLSVTLIYIP 2706 AY+IYTSG+TG PKGVM H G+ N + W + H A + FD + + P Sbjct: 406 AYVIYTSGTTGKPKGVMVEHGGIVNSLQWKKAFFRHSPADRVLVLYPYVFDAFILNFFGP 465 Query: 2707 LISGNKVFIYSGVSYESL--LEAVVIDNQVDFIMLTPSHLKILGEYDLSR---LKIRKFI 2761 LISG + + + ++ + ++ +P LK + E ++R + ++ + Sbjct: 466 LISGATLHLLPNKENKETFAIQNAIKQERITHFSTSPRLLKTMIE-QMNREDFIHVQHVV 524 Query: 2762 IGGEAFDPFYAKKFFSRLAEDVEVYNVYGPTETTVACTFYRYYPDKDLRNPVPIGGPIFN 2821 +GGE + +K S L + + N YGPTE +V TF+ P + + IG P+ N Sbjct: 525 VGGEQLEADTVEKLHS-LQPRIRINNEYGPTENSVVSTFH---PVQSADEQITIGSPVAN 580 Query: 2822 VQLYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREELTREKFVPDPFQTSGMMYRTGDL 2881 Q Y++ + ++Q IG+PGEL + G GV+RGYLNR ELT EKFV MY+TGDL Sbjct: 581 HQAYILGAHHQIQPIGVPGELYVGGAGVARGYLNRPELTEEKFVEHLHVPGQKMYKTGDL 640 Query: 2882 VRMLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCA 2941 R L DG +E+LGR+D QVKIRG+RIE+GE+E + V +AAV+ ++ L A Sbjct: 641 ARWLPDGRIEYLGRIDHQVKIRGYRIEIGEVEAAMFNLENVREAAVVAREDADGAKQLYA 700 Query: 2942 YYTADFPMNXXXXXXXXXXXXPRHMVPSFFVQMKSIPLTASGKVDRKKLPDSFESFQMED 3001 YY + + P +M+PS F+ ++ IPLT++GK+D K LP + E+ + E+ Sbjct: 701 YYVGEPSLTAAQFREELSRELPNYMIPSRFIPLERIPLTSNGKIDLKALPAADENTRAEN 760 Query: 3002 AYSAPQNFIEEKLALVWEEVLGINKVGTSNSFIKLGGDSIKAIQIVSRLKKYGLSLEVKE 3061 Y AP+N IEE LA +W+EVLG ++G ++F GGDSIK+IQ+ SRL + G +++K Sbjct: 761 EYIAPRNTIEELLASIWQEVLGAERIGILDNFFDFGGDSIKSIQVSSRLYQAGYKVDMKH 820 Query: 3062 LFLHQNIKGISPFVKQNIKRHNQGTIEGPVKLTAIQKWFFEQNFAEMHHWNQSILLHN-E 3120 LF H +I +S FV + +QG + G KLT IQ WFFEQ HH+NQ+++L++ E Sbjct: 821 LFKHPSIAELSQFVAPVSRVADQGEVNGGTKLTPIQHWFFEQKMPHAHHYNQAVMLYSAE 880 Query: 3121 RFDVQFIRQAFQRITEHHDALRMVYRHTGQAGVEQSNRGLAGELFSLEVTDLTGCDDHTD 3180 F +R+ +RI HHDALRM++ T + ELF LEV + G D Sbjct: 881 GFKEGPLRRTMERIASHHDALRMIFEKTPDGYAPRITGTDESELFHLEVMNYKGETDPAQ 940 Query: 3181 LMHAGIKTIQKGIDLEKGPLLKLGLYQTTNGDYLAIVIHHLVVDGVSWRIILDDFASCYL 3240 + IQ + L+KGPL+KLGL+Q +GD+L I IHHL++DGVSWRI+L+DFAS Y Sbjct: 941 AIADKANEIQSSMVLDKGPLMKLGLFQCPDGDHLLIAIHHLLIDGVSWRILLEDFASGYE 1000 Query: 3241 SLDNGEEAGLIEKSDSYQKWAEALEVYANSPKLLQELAYWTDVNRIAVPALPKDSEAGNG 3300 + G+ +K+DS+ WA L YA + +E+AYWT+++ I LPKD+ + Sbjct: 1001 QAERGQTIQFPQKTDSFPFWAGQLSKYAAETDMEEEIAYWTELSSIKPQPLPKDTISEGS 1060 Query: 3301 KIKDRYQTKTVLSEKETTNLLRHAGDAYQTETXXXXXXXXXXXIKGWANVDRVRINMEGH 3360 ++D + +++ET LL+ A AY T+ + W + + +N+EGH Sbjct: 1061 LLRDSEEVTIQWTKEETEQLLKQANHAYNTDINDLLLTSLGLAVHKWTGTEEIVVNLEGH 1120 Query: 3361 GREALIQDLDITRTVGWFTSTYPLVLELANSHELPLHIMTTKETIRQTPNKGMGYQVLKY 3420 GRE +I D DI+RT+GWFTS YP+VL + L I KE +R+ P+KGM Y ++KY Sbjct: 1121 GREPIIPDADISRTIGWFTSQYPVVLRMEAGKNLSQRIKIVKEGLRRIPDKGMNYSIIKY 1180 Query: 3421 LTSPELRAAVDFNVMPEISFNYLGQFGNEASYGTFEIC--NTFMESTESPESHRPYAIDI 3478 ++ ++ N PEISFNYLGQF + + I +T + E+ E R +D+ Sbjct: 1181 ISGHSEADSLQLN--PEISFNYLGQFDQDLKHQALRISPFSTGLSMNENQE--RTAVLDL 1236 Query: 3479 NAMIVGNRVEIRVDYNPGQFNEATMSRFAELLLNSLKLIISHCTREERIQRSPSDLTYKK 3538 N MI + + + Y+ Q+ +TM++FA L SL+ +I+HC ++ +PSD+ K Sbjct: 1237 NGMIAEGTLSLTLSYSSKQYERSTMAQFARGLKESLQEVIAHCVSRQQTSLTPSDILLKD 1296 Query: 3539 LTFEELDDL--NRLYPGGITDVYTMTPMQESMLFHALKNKRSDAYHEQCILDLKGDIIQE 3596 ++ +EL+ L G ++Y +TPMQ+ MLFH+L + S AY +Q + DL GD+ + Sbjct: 1297 ISIDELEQLLEQTRELGEAENIYPLTPMQKGMLFHSLFDPNSGAYFQQTMFDLHGDLEID 1356 Query: 3597 LLNESFKLIVGKYDILRTRFVYKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERL 3656 ++S + KYDI RT F +PLQI+ + +F D+ M+ S+K A +++ Sbjct: 1357 SFSKSLDGLSQKYDIFRTNFYRGWKDQPLQIIFKTKKIGFQFNDLREMKESQKEAMIQQY 1416 Query: 3657 KALDREKRFDLVQGPLMRAILLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLN 3716 D+ + FDL +G LMR +L+T + Y+ +WSFHHILMDGWC+ ++ K++ E+Y L Sbjct: 1417 AREDKMRGFDLEKGALMRLFILRTDEKTYRFIWSFHHILMDGWCLPLITKEIFENYFALL 1476 Query: 3717 AGSRPSLET-HQYRLYLDWLASKNKEEAKVYWMQYLEDYKYKELLRKEGTSKE---FRLA 3772 +P + Y Y++WL ++ +EA YW QYLE Y+ + L K+ + E + Sbjct: 1477 QQKQPEQSSITPYSQYIEWLGRQDAKEATAYWDQYLEGYEEQTGLPKDHHAAEDGRYVPE 1536 Query: 3773 VLDIKLEEKVRTAVTHVASSSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGRSPEIE 3832 + + + + + A +T+N+ Q W +LL KY+ + DVVFG+V+SGR I Sbjct: 1537 KVTCDISSDLTSKMKRTAGKHHVTLNTLLQTAWAVLLQKYNRSRDVVFGSVVSGRPAGIP 1596 Query: 3833 GIERMVGLFINTIPVRVRL-SGKTFHELAGEIQSSFISSEQYGYVPLSDIQAWS--HRDL 3889 +E M+GLFINTIPVR R +G TF L E Q ++S+Q+ PL DIQA + +DL Sbjct: 1597 NVETMIGLFINTIPVRFRCEAGTTFAGLMKEAQERAVASQQFETHPLYDIQARTTQKQDL 1656 Query: 3890 INHVMVFENYPLDREIRDTDGQQMEYGFQIAGCEILEHTNYDFSIIIEPGEDFIIRIVYN 3949 I H+M+FENYP+D+ + ++ G+Q I+ ++ E TNYDF++ + PG++ I YN Sbjct: 1657 ITHLMIFENYPVDQYM-ESIGRQNGTSITISNVQMEEQTNYDFNLTVIPGDEMNISFEYN 1715 Query: 3950 ALAYDKETISILESYLLAIIGQVTACPQIEAGDVEVLSQEEKLKLMNVFN 3999 A Y++ +I + + + I+ QV I E+L++ E+ L+ N Sbjct: 1716 ANVYERASIERVREHFMQILHQVVTDADIRVDQAELLTEGERRTLLQTLN 1765 Score = 877 bits (2265), Expect = 0.0, Method: Compositional matrix adjust. Identities = 531/1546 (34%), Positives = 836/1546 (54%), Gaps = 95/1546 (6%) Query: 1801 ILDKDMHPSPVGVPGEVYLA------------RLTEPSLLA-----EQPSTSTGIMAMYT 1843 ILD P GV GE+Y+A LT+ +A E TG +A Sbjct: 3617 ILDSKKRLQPKGVQGELYIAGDGVGRGYLNLPELTDEKFVADPFVPEDRMYRTGDLARLL 3676 Query: 1844 ADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKP--------SGTFQR 1895 D I+ IG + G I L I+ ++ P I AA G F Sbjct: 3677 PDGNIEYIGRIDHQVKIQGFRIELGEIESVMLNVPDIQEAAAAALKDADDEYYLCGYFAA 3736 Query: 1896 DQKILAYITPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAF 1955 D+ I ++ E+++ + +PG IP+ F+ LD++PL G +N +LLPA Sbjct: 3737 DKTI------------QISELRERMARHLPGYMIPAHFVQLDKMPLTPNGKLNRQLLPAP 3784 Query: 1956 DEDKALREEIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKE 2015 + + E + P+ E +L IW +VL LE V D FFE+GG+SL+A+ L IQK+ Sbjct: 3785 VKKRDSGIEYVPPQTSAEIQLTAIWEDVLGLEQVGIRDHFFEIGGHSLRATALIAKIQKQ 3844 Query: 2016 FSTDISLRMLFEHPTVKGLAKAINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGG 2075 I LR +F PT++ LA+ I + I + K+ +YP SS+QKRL+ + + G Sbjct: 3845 MHVQIPLRDVFRFPTIEQLARTITKTELTGYAAIPAIEKRPYYPVSSAQKRLYILNHLEG 3904 Query: 2076 AGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSIS 2135 +YN+ G++ VEGKLD ++++AF+ L+ RHE LRT F++ EPVQ + D F Sbjct: 3905 GELSYNMLGLMTVEGKLDRDKLQQAFRTLILRHESLRTGFKMADGEPVQYVLDHAAFEAE 3964 Query: 2136 YSIAEDEDEPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIADGISANILC 2195 + E++D +++FI PF L++ PL RV ++ I++ DMHHII+DG S ++L Sbjct: 3965 WYQGEEDDADLYIRQFIRPFHLDEPPLLRVGLIELQPDRGILMFDMHHIISDGTSMSVLI 4024 Query: 2196 NDLISLYSGENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDDIPSLTLPLDFP 2255 + I +Y GE LP L +QYKDY ++I++Q YW +L S D+P L LP D+ Sbjct: 4025 KEFIRIYEGETLPPLRIQYKDYAVWQTSEARLQQIQKQEAYWLELYSGDVPVLHLPADYI 4084 Query: 2256 RPPVQSFDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYSNQEDIVIGS 2315 RP + F GA TLD + GLK L+++ ++TLY +LLASY +LLSKYS QEDI++GS Sbjct: 4085 RPSARDFAGATMHFTLDKQKSDGLKQLASQTESTLYMVLLASYTLLLSKYSGQEDIIVGS 4144 Query: 2316 PVAGRFNYSTNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELIS 2375 P+AGR + ++GMFVNTLAMRN P K KTF ++L EVKEN L+A+E+QDYPFE LI Sbjct: 4145 PIAGRPHADLEPIIGMFVNTLAMRNYPEKGKTFSQYLSEVKENALKAYEHQDYPFEALID 4204 Query: 2376 KLGIERDISRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKFDLILEVIENTE 2435 +L I RD+SRNP+FD MFVLQ+ + + ++D+ Y + +AKFDL L +E Sbjct: 4205 QLNIARDLSRNPLFDTMFVLQNTEQE--QLEINDVTFKPYPNGHTMAKFDLTLTAVEEGA 4262 Query: 2436 NLTLNFEYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPKEETDRLIYTFND 2495 ++ EY LF+ TI RM F +++ ++++ L+ ++++ KEE + FND Sbjct: 4263 SIQFTLEYLTALFKPETIERMMGHFEQLVDSIIKQPEAELARLNMMTKEEERDIQQLFND 4322 Query: 2496 TATAYPG-GKTVYQLFEEQAARTPGAVALVHQGESITYEHFNRKTNQMARMLRSKGVKPD 2554 TA A T++QLFE+QA R P A++ +++TY N ++NQ+AR+L+ KG D Sbjct: 4323 TAVAEKRIPTTIHQLFEQQAERNPDHEAVMFGNQTLTYRQLNERSNQLARVLQDKGACTD 4382 Query: 2555 TTVGILMEHSFELIISMFAVMKAGGAYVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEK 2614 V +L + S +II + A++KAG A++PIDP P +R F++KDS +++LT G A Sbjct: 4383 QVVAVLTDRSAHMIIGILAILKAGAAFLPIDPELPEKRRAFMLKDSGADVLLTCAGHAIP 4442 Query: 2615 CQFQGEFIDAASSKWYCGDDSNPVSVNSPDDLAYIIYTSGSTGLPKGVMTRHQGLTNYVW 2674 F+GE + Y G N S +DL Y+IYTSG+TG PKGV H+ +TN + Sbjct: 4443 PLFEGEVLLLDDPLLYQGRTDNLNLSCSENDLMYVIYTSGTTGQPKGVQLEHKTMTNLLA 4502 Query: 2675 W-GDKTYVHGEAVDFPLYSSIAFDLSVTLIYIPLISGNKVFIYSGVSYESL--LEAVVID 2731 + D T + + V +++++FD+ ++ L SG +FI + + L V Sbjct: 4503 YEQDHTQLRFDRV--LQFAAMSFDVCYQEMFSALSSGGTLFIIGNEAKRDIRQLNDFVRT 4560 Query: 2732 NQVDFIMLTPSHLKILGE----YDLSRLKIRKFIIGGEAFDPFYAKKFFSRLAE-DVEVY 2786 + + L + LK+L ++ + I GE + LA V ++ Sbjct: 4561 HGIQTAFLPTAFLKLLASEKHYFEPFAECVDHIIAAGEQL--IATRMLRDMLARHQVTLH 4618 Query: 2787 NVYGPTETTVACTFYRYYPDKDLRNPVPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAG 2846 N YGP+ET V T Y PD D + PIG PI N +++++++ G LQ +GI GELCI+G Sbjct: 4619 NHYGPSETHV-VTMYTVDPDTD-QELQPIGKPISNTEIFILNEAGTLQPVGIVGELCISG 4676 Query: 2847 DGVSRGYLNREELTREKFVPDPFQTSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHR 2906 ++RGY NRE LT E FVP P+ ++ MY+TGDL R L +GN+E+ GR D QVKIRG+R Sbjct: 4677 VSLARGYHNRESLTLETFVPHPYDSNQRMYKTGDLARYLPEGNIEYAGRRDHQVKIRGYR 4736 Query: 2907 IELGEIENQLVKQPGVNKAAVIISTGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHM 2966 +ELGE+E L+K V +A V+ L AY+TA+ ++ P +M Sbjct: 4737 VELGEVEAALLKH--VQEAVVLAKENTDGQSDLYAYFTAEQSLSISQLKEKLAGQIPGYM 4794 Query: 2967 VPSFFVQMKSIPLTASGKVDRKKLPDSFESFQMEDAYSAPQNFIEEKLALVWEEVLGINK 3026 +PS+F+Q++ +PLT +GKV+R+ LP Q Y AP+ +EE+L +W++VL + + Sbjct: 4795 IPSYFIQLEKLPLTGNGKVNRRALPMPEAGLQTGTDYVAPRTNMEEQLICIWQDVLKVKE 4854 Query: 3027 VGTSNSFIKLGGDSIKAIQIVSRL-KKYGLSLEVKELFLHQNIKGISPFVKQNIKRHNQG 3085 +G ++F LGG S++ + +++++ K++ ++ ++E+F P V++ + + Sbjct: 4855 IGVKDNFFDLGGHSLRGMTLIAKIHKQFSKNISLREVFQ-------CPTVEEMAQAIAEA 4907 Query: 3086 TIEGP-----------VKLTAIQKWFF---EQNFAEMHHWNQSILLHNERFDVQFIRQAF 3131 GP ++++QK + + E+ + IL + D+ ++ AF Sbjct: 4908 ETNGPDYIPKAKAKDVYPVSSVQKMVYLSTQIEGGELSYNMPGILTLEGKLDMNRLQTAF 4967 Query: 3132 QRITEHHDALRMVYRHTGQAGVEQSNRGLAGELFSLEVTDLTGCDDHTDLMHAGIKTIQK 3191 QR+ + H++LR + V+ + FS+E T D + +T + Sbjct: 4968 QRLIQRHESLRTGFEMVRGEPVQVIKSQVE---FSMERYKATA-----DEVEECFRTFVR 5019 Query: 3192 GIDLEKGPLLKLGLYQTTNGDYLAIV-IHHLVVDGVSWRIILDDFASCYLSLDNGEEAGL 3250 DL + PLL+ GL + ++ + +HH++ DG S I +++ Y D E A L Sbjct: 5020 PFDLSQAPLLRAGLIELEQDLHIFMFDMHHIITDGASMNIFVEELIQLY---DGKELAPL 5076 Query: 3251 IEKSDSYQKWAEALEVYANSPKLLQELAYWTDVNRIAVPA--LPKD 3294 + + +W E ++ + YW V +P+ LPKD Sbjct: 5077 RIQYKDFTEWKHQKE---QRERIKSQEEYWLGVFHEELPSFELPKD 5119 Score = 540 bits (1391), Expect = e-151, Method: Compositional matrix adjust. Identities = 384/1288 (29%), Positives = 638/1288 (49%), Gaps = 92/1288 (7%) Query: 2058 YPQSSSQKRLFAIEQMGGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSF-E 2116 YP + QK + + A ++Y ++G+L + + +RL + + LRT F Sbjct: 2828 YPLTPMQKGMLFHSLLDEASSSYFEQASFDLQGELKIDWFKASLERLFETYAVLRTRFYS 2887 Query: 2117 LLHDEPVQVIHDDIPFSISYSIAED------EDEPELVKR--FILPFSLNQAPLFRVHIV 2168 +D P+Q+++ I ++ D ED +R F L + PL R+ I Sbjct: 2888 GWNDTPLQIVYKTQTPQIHFADLRDIEEHLREDAIAAYQREDKAKGFDLARDPLMRIAIF 2947 Query: 2169 SRSDHEHIVIMDMHHIIADGISANILCNDLISLYSG-----ENLPGLEVQYKDYTALHNE 2223 D ++ +I HHI+ DG +++ ++ YS E P V Y DY E Sbjct: 2948 RMEDRKYHLIWSFHHIVMDGWCLSLITKEVFDHYSALQEGREPEPLSAVPYSDYI----E 3003 Query: 2224 MLSNERIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLS 2283 L + YW L TL + + + A D + T+ L+ ++ Sbjct: 3004 WLDRQDQGAAKRYWGGYLEGYKGETTLLHKIAQHEQKEYAYANLICRFDHEQTKQLQQIA 3063 Query: 2284 NRLKTTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRFNY--STNNMVGMFVNTLAMRNQ 2341 N+ + TL TL+ + +LL KYS D+V GS V+GR M+G+F+NT+ +R + Sbjct: 3064 NQHQVTLNTLIQTLWGVLLQKYSGSADVVFGSVVSGRPAEIPDVEQMIGLFINTIPVRIR 3123 Query: 2342 PAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERD-ISRNPVFDVMFVLQSLDL 2400 + TF + + V++N L + YP E+ ++ +++ I +F+ + Q + Sbjct: 3124 CDEDSTFADTMQMVQQNALASQSYDTYPLYEIQAQTEQKQNLIDHIMIFENYPIGQQAEE 3183 Query: 2401 AVPDVHLDDIRLNGYEFKNDVAKFDLILEVIENTENLTLNFEYCAKLFQESTIIRMSERF 2460 H ++ + + + + +DL + VI + L ++F + +++S + R+ F Sbjct: 3184 T--GHHGTELNITNFHMQEH-SHYDLNVVVIPGKQ-LAVHFGFNKNEYEKSEVERLRGHF 3239 Query: 2461 LRILTTVVENCNVLLSDIDLLPKEETDRLIYTFNDTATAYPGGKTVYQLFEEQAARTPGA 2520 +++ V+ +V + D++LL ++E + L+ F YP KT+++LFEEQA RTP Sbjct: 3240 EKLMQQVLRQPSVKIEDLELLSQQEKEYLLSRFQSNDMHYPREKTIHELFEEQAHRTPDN 3299 Query: 2521 VALVHQGESITYEHFNRKTNQMARMLRSKGVKPDTTVGILMEHSFELIISMFAVMKAGGA 2580 A+V +G+ TYE NR+ NQ+AR L++KGV+ D VGI+ E S E+++ + V+KAGGA Sbjct: 3300 TAVVFEGKQFTYEELNRRANQLARTLQAKGVQADQLVGIMTERSLEMVVGILGVLKAGGA 3359 Query: 2581 YVPIDPTYPSERINFIIKDSNLEIMLTHKGLAEKCQFQGEFIDAASSKWYCGDDSNPVSV 2640 Y+PIDP PSERI +I+ DS++ ++L L + F G ID +Y DS+ Sbjct: 3360 YLPIDPDSPSERIRYILNDSSISVLLYCGKLQDDIGFSGTCIDLMEEHFYHEKDSSLALS 3419 Query: 2641 NSPDDLAYIIYTSGSTGLPKGVMTRH-------QGLTNYVWWGDKTYVHGEAVDFPLYSS 2693 LAY IYTSG+TG PKG + H +GL+ V+ + ++ + + Sbjct: 3420 YQSSQLAYAIYTSGTTGKPKGTLIEHRQVIHLIEGLSRQVYSA-----YDAELNIAMLAP 3474 Query: 2694 IAFDLSVTLIYIPLISGNKVFIYSG--VSYESLLEAVVIDNQVDFIMLTPSHLKIL-GEY 2750 FD SV +Y L+SG+ +FI VS + L + +D TP+HLK+L Sbjct: 3475 YYFDASVQQMYASLLSGHTLFIVPKEIVSDGAALCRYYRQHSIDITDGTPAHLKLLIAAG 3534 Query: 2751 DLSRLKIRKFIIGGEAFDPFYA---KKFFSRLAEDVEVYNVYGPTETTVACTFYRYYPDK 2807 DL + ++ +IGGEA K+ F + NVYGPTET V + + Sbjct: 3535 DLQGVTLQHLLIGGEALSKTTVNKLKQLFGEHGAAPGITNVYGPTETCVDASLFNIECSS 3594 Query: 2808 DL----RNPVPIGGPIFNVQLYVVDQNGKLQGIGIPGELCIAGDGVSRGYLNREELTREK 2863 D +N VPIG P+ ++Y++D +LQ G+ GEL IAGDGV RGYLN ELT EK Sbjct: 3595 DAWARSQNYVPIGKPLGRNRMYILDSKKRLQPKGVQGELYIAGDGVGRGYLNLPELTDEK 3654 Query: 2864 FVPDPFQTSGMMYRTGDLVRMLQDGNVEFLGRMDDQVKIRGHRIELGEIENQLVKQPGVN 2923 FV DPF MYRTGDL R+L DGN+E++GR+D QVKI+G RIELGEIE+ ++ P + Sbjct: 3655 FVADPFVPEDRMYRTGDLARLLPDGNIEYIGRIDHQVKIQGFRIELGEIESVMLNVPDIQ 3714 Query: 2924 KAAVIISTGPTDSRYLCAYYTADFPMNXXXXXXXXXXXXPRHMVPSFFVQMKSIPLTASG 2983 +AA D YLC Y+ AD + P +M+P+ FVQ+ +PLT +G Sbjct: 3715 EAAAAALKDADDEYYLCGYFAADKTIQISELRERMARHLPGYMIPAHFVQLDKMPLTPNG 3774 Query: 2984 KVDRKKLPDSFESFQMEDAYSAPQNFIEEKLALVWEEVLGINKVGTSNSFIKLGGDSIKA 3043 K++R+ LP + Y PQ E +L +WE+VLG+ +VG + F ++GG S++A Sbjct: 3775 KLNRQLLPAPVKKRDSGIEYVPPQTSAEIQLTAIWEDVLGLEQVGIRDHFFEIGGHSLRA 3834 Query: 3044 IQIVSRL-KKYGLSLEVKELFLHQNIKGISPFVKQNIKRHNQGTIEGPVKLTAIQKWFF- 3101 +++++ K+ + + ++++F P ++Q + + + G + AI+K + Sbjct: 3835 TALIAKIQKQMHVQIPLRDVFRF-------PTIEQLARTITKTELTGYAAIPAIEKRPYY 3887 Query: 3102 -----EQNFAEMHHWNQSILLHNE--------RFDVQFIRQAFQRITEHHDALRMVYRHT 3148 ++ ++H L +N + D ++QAF+ + H++LR ++ Sbjct: 3888 PVSSAQKRLYILNHLEGGELSYNMLGLMTVEGKLDRDKLQQAFRTLILRHESLRTGFKMA 3947 Query: 3149 GQAGVEQSNRGLAGELFSLEVTDLTGCDDHTDLMHAGIKTIQKGIDLEKGPLLKLGLYQT 3208 V+ + + E G +D DL I+ + L++ PLL++GL + Sbjct: 3948 DGEPVQ-----YVLDHAAFEAEWYQGEEDDADLY---IRQFIRPFHLDEPPLLRVGLIEL 3999 Query: 3209 T-NGDYLAIVIHHLVVDGVSWRIILDDFASCYLSLDNGEEAGLIEKSDSYQKWAEALEVY 3267 + L +HH++ DG S +++ +F Y E L Y+ +A V+ Sbjct: 4000 QPDRGILMFDMHHIISDGTSMSVLIKEFIRIY------EGETLPPLRIQYKDYA----VW 4049 Query: 3268 ANSPKLLQEL----AYWTDVNRIAVPAL 3291 S LQ++ AYW ++ VP L Sbjct: 4050 QTSEARLQQIQKQEAYWLELYSGDVPVL 4077 Score = 506 bits (1304), Expect = e-141, Method: Compositional matrix adjust. Identities = 285/717 (39%), Positives = 424/717 (59%), Gaps = 28/717 (3%) Query: 1785 ELDKYGVSWDEADIFVILDKDMHPSPVGVPGE-----VYLAR-------LTEPSLL---- 1828 EL G +IF IL++ PVG+ GE V LAR LT + + Sbjct: 4641 ELQPIGKPISNTEIF-ILNEAGTLQPVGIVGELCISGVSLARGYHNRESLTLETFVPHPY 4699 Query: 1829 -AEQPSTSTGIMAMYTADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTV 1887 + Q TG +A Y + I+ G + G + L ++ L+ H + A V Sbjct: 4700 DSNQRMYKTGDLARYLPEGNIEYAGRRDHQVKIRGYRVELGEVEAALLKH--VQEAVVLA 4757 Query: 1888 KPSGTFQRDQKILAYITPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGI 1947 K + Q D + AY T + + ++K+ L +IPG IPS F+ L+++PL G + Sbjct: 4758 KENTDGQSD--LYAYFTAEQSL--SISQLKEKLAGQIPGYMIPSYFIQLEKLPLTGNGKV 4813 Query: 1948 NERLLPAFDEDKALREEIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASL 2007 N R LP + + + P EE+L IW++VL ++ + D+FF+LGG+SL+ Sbjct: 4814 NRRALPMPEAGLQTGTDYVAPRTNMEEQLICIWQDVLKVKEIGVKDNFFDLGGHSLRGMT 4873 Query: 2008 LAFSIQKEFSTDISLRMLFEHPTVKGLAKAINGAGKSFLPEITPLGK-KDWYPQSSSQKR 2066 L I K+FS +ISLR +F+ PTV+ +A+AI A ++ P+ P K KD YP SS QK Sbjct: 4874 LIAKIHKQFSKNISLREVFQCPTVEEMAQAIAEA-ETNGPDYIPKAKAKDVYPVSSVQKM 4932 Query: 2067 LFAIEQMGGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVI 2126 ++ Q+ G +YN+ GIL +EGKLD R++ AFQRL++RHE LRT FE++ EPVQVI Sbjct: 4933 VYLSTQIEGGELSYNMPGILTLEGKLDMNRLQTAFQRLIQRHESLRTGFEMVRGEPVQVI 4992 Query: 2127 HDDIPFSISYSIAEDEDEPELVKRFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIA 2186 + FS+ A ++ E + F+ PF L+QAPL R ++ HI + DMHHII Sbjct: 4993 KSQVEFSMERYKATADEVEECFRTFVRPFDLSQAPLLRAGLIELEQDLHIFMFDMHHIIT 5052 Query: 2187 DGISANILCNDLISLYSGENLPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQLLSDDIP 2246 DG S NI +LI LY G+ L L +QYKD+T ++ ERI+ Q EYW + +++P Sbjct: 5053 DGASMNIFVEELIQLYDGKELAPLRIQYKDFTEWKHQKEQRERIKSQEEYWLGVFHEELP 5112 Query: 2247 SLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLSNRLKTTLYTLLLASYNILLSKYS 2306 S LP DF RPPV+SFDG ++ TLD +T+G+K L TT Y +L ++Y+ILL+KYS Sbjct: 5113 SFELPKDFARPPVRSFDGKRHNFTLDKTVTQGIKQLEELTGTTAYMILFSAYSILLAKYS 5172 Query: 2307 NQEDIVIGSPVAGRFNYSTNNMVGMFVNTLAMRNQPAKHKTFQEFLLEVKENTLEAFENQ 2366 Q+DIV+G+P+AGR + ++GMFVNTLA+R P KTF +++ E KE L+AFE+Q Sbjct: 5173 GQDDIVVGTPIAGRPHADLEPIIGMFVNTLAIRTAPMAEKTFLDYITETKETMLKAFEHQ 5232 Query: 2367 DYPFEELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLDDIRLNGYEFKNDVAKFDL 2426 +YPFEEL+ KLG++RD+SRNP+FD MFVLQ+ + D+ +D + + YE AKFDL Sbjct: 5233 EYPFEELVEKLGVKRDLSRNPLFDTMFVLQNTEQT--DIEVDSLAVRPYEQTETAAKFDL 5290 Query: 2427 ILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTTVVENCNVLLSDIDLLPK 2483 L + + + + +F+YC KLF++ TI +++ ++ IL+ ++ N ++ L DI L K Sbjct: 5291 QLNFLIDQDEIQGSFDYCTKLFKKKTIAVLAKDYVMILSAIMRNPSIPLKDIQLSEK 5347 Score = 168 bits (426), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 182/723 (25%), Positives = 314/723 (43%), Gaps = 83/723 (11%) Query: 1801 ILDKDMHPSPVGVPGEVYLA-------RLTEPSLLAE-------QPST---STGIMAMYT 1843 +LD++M P+P+GVPGE+Y++ L P L AE +P TG +A + Sbjct: 2097 VLDENMKPAPIGVPGEIYISGAGVARGYLNRPELTAEKFVDDLFEPGAKMYKTGDLAKWL 2156 Query: 1844 ADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAYI 1903 AD I+ G + G I L I+ L+ I A VT + +++ AY Sbjct: 2157 ADGNIEYAGRIDEQVKIRGYRIELGEIEAALLQEEAIKEAVVTARED--VHGFKQLCAYY 2214 Query: 1904 TPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALRE 1963 G + ++K L + +P+ F+ LDE+PL S G IN + LPA + + R Sbjct: 2215 VSGGQTT--AARLRKQLSQTLASYMVPAYFIELDEMPLTSNGKINRKGLPAPNFELQDRA 2272 Query: 1964 EIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDISLR 2023 E P + EE L W +VL E V+ D+FF+LGG+S+K+ ++ + ++ + ++ Sbjct: 2273 EYKAPRTKAEEILVSAWESVLGAENVSILDNFFDLGGDSIKSIQVSSRLNQQ-GYKMEIK 2331 Query: 2024 MLFEHPTVKGLAKAI--------NGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIEQMGG 2075 LF++ T+ L+ I G K + +TP+ + W+ + ++ + + Sbjct: 2332 DLFQYATIAELSPHIKQNLRIADQGEVKGKV-SLTPI--QHWFFEQTTTDQHY------- 2381 Query: 2076 AGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSFELLHDEPVQVIHDDIPFSIS 2135 YN +LH ++ + Q+L + H+ LR +F + + +++I S Sbjct: 2382 ----YNQAVMLHAPEGFQETQLRQTLQKLAEHHDALRMTFRTTEN-GCEAQNEEIAQSGL 2436 Query: 2136 Y-----SIAEDEDEPELVK----RFILPFSLNQAPLFRVHIVSRSDHEHIVIMDMHHIIA 2186 Y ++ ED D ++ L+ PL + + ++ +H++I +HH+I Sbjct: 2437 YRLEVLNLKEDSDPGRTIEAKADEIQSSMRLSDGPLMKAGLFQCANGDHLLIA-IHHLII 2495 Query: 2187 DGISANILCNDLISLY-SGEN-----LPGLEVQYKDYTALHNEMLSNERIRQQGEYWQQL 2240 DGIS IL D++S Y EN LP ++ + +E +E I+Q+ EYW ++ Sbjct: 2496 DGISWRILLEDIVSGYKQAENVRVIQLPQKTDSFQLWAKRLSEYAQSETIKQEQEYWTKI 2555 Query: 2241 LSDDIPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRGLKVLSNR-LKTTLYTLLLASYN 2299 ++ LP DF + D +V + T L +NR T + LLL S Sbjct: 2556 EQTEVKP--LPKDFHETHTTAKDSETATVEWTKEETELLLKQANRAYHTEINDLLLTSLG 2613 Query: 2300 ILLSKYSNQEDIVIGSPVAGR----FNYSTNNMVGMFVNT--LAMRNQPAKH-----KTF 2348 + +S +S E I I GR + + VG F + + + QP K KT Sbjct: 2614 LSISHWSGLEQIPIHLEGHGREQIIQDIDISRTVGWFTSLYPVVLHAQPGKEISDYIKTT 2673 Query: 2349 QEFLLEVKENTLEAFENQDYPFEELISKLGIERDISRNPVFDVMFVLQSLDLAVPDVHLD 2408 +E L ++ + + Y + SKL E + FD DL V L Sbjct: 2674 KEGLRQIPHKGI-GYGIARYLSGGMPSKLNPEISFNYLGQFDQ-------DLQQHGVQLS 2725 Query: 2409 DIRLNGYEFKNDVAKFDLILEVIENTENLTLNFEYCAKLFQESTIIRMSERFLRILTTVV 2468 +N + L + + L L Y +K + + TI+R+SE L T++ Sbjct: 2726 SYSCGSDSSENQERPYVLNINGMITEGRLKLTISYSSKQYAKETIMRLSETIQSRLRTII 2785 Query: 2469 ENC 2471 +C Sbjct: 2786 THC 2788 Score = 144 bits (364), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 101/395 (25%), Positives = 175/395 (44%), Gaps = 16/395 (4%) Query: 1361 LYLRGELNKAALETAYHKVLNRHESLRSTISADGNE--QIVASHANADIFFADILADYSA 1418 L L G+L+ L+TA+ +++ RHESLR+ E Q++ S + Y A Sbjct: 4952 LTLEGKLDMNRLQTAFQRLIQRHESLRTGFEMVRGEPVQVIKSQVEFS------MERYKA 5005 Query: 1419 LGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIADGWSLIVFLQE 1478 DE + + FD PL+R ++ + ++ HHII DG S+ +F++E Sbjct: 5006 TADEV--EECFRTFVRPFDLSQAPLLRAGLIELEQDLHIFMFDMHHIITDGASMNIFVEE 5063 Query: 1479 LAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQPKEKAAAYWKNKFSVQTPAFELPS 1538 L LY + L P + D+ W+ + + + + YW F + P+FELP Sbjct: 5064 LIQLYDG-----KELAPLRIQYKDFTEWKHQKEQRERIKSQEEYWLGVFHEELPSFELPK 5118 Query: 1539 FRIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVSLFTVLLSAYKVLLYRISNHKELV 1598 R G RH + LD +T +K + + + + +L SAY +LL + S ++V Sbjct: 5119 DFARPPVRSFDGKRHNFTLDKTVTQGIKQLEELTGTTAYMILFSAYSILLAKYSGQDDIV 5178 Query: 1599 VGIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXXXXXXXXQDYSYAS 1658 VG P AG+ + ++G +N L T E TF Q+Y + Sbjct: 5179 VGTPIAGRPHADLEPIIGMFVNTLAIRTAPMAEKTFLDYITETKETMLKAFEHQEYPFEE 5238 Query: 1659 LMKELHSLDGSVHPPQINTMFNMDKSLETP-DFTGMDVELLQSPVSYSKYDLSMNIVELD 1717 L+++L P +TMF + + +T + + V + + +K+DL +N + Sbjct: 5239 LVEKLGVKRDLSRNPLFDTMFVLQNTEQTDIEVDSLAVRPYEQTETAAKFDLQLNFLIDQ 5298 Query: 1718 HELMIDFEYDPNLFDTQIITGWANYFNRILLAVLQ 1752 E+ F+Y LF + I A + IL A+++ Sbjct: 5299 DEIQGSFDYCTKLFKKKTIAVLAKDYVMILSAIMR 5333 Score = 133 bits (335), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 108/409 (26%), Positives = 186/409 (45%), Gaps = 20/409 (4%) Query: 1352 GVVHHETVGLY-LRGELNKAALETAYHKVLNRHESLRSTIS-ADGNE-QIVASHANADIF 1408 G + + +GL + G+L++ L+ A+ ++ RHESLR+ ADG Q V HA F Sbjct: 3905 GELSYNMLGLMTVEGKLDRDKLQQAFRTLILRHESLRTGFKMADGEPVQYVLDHA---AF 3961 Query: 1409 FADILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHEYLLALSAHHIIAD 1468 A+ G+E +++ F PL+R+ ++ +L HHII+D Sbjct: 3962 EAEWYQ-----GEEDDADLYIRQFIRPFHLDEPPLLRVGLIELQPDRGILMFDMHHIISD 4016 Query: 1469 GWSLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQPKEKAAAYWKNKFS 1528 G S+ V ++E +Y E +L P + DYA+WQ Q +K AYW +S Sbjct: 4017 GTSMSVLIKEFIRIYEGE-----TLPPLRIQYKDYAVWQTSEARLQQIQKQEAYWLELYS 4071 Query: 1529 VQTPAFELPSFRIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVSLFTVLLSAYKVLL 1588 P LP+ IR +A G+ + LD + LK ++ + +L+ VLL++Y +LL Sbjct: 4072 GDVPVLHLPADYIRPSARDFAGATMHFTLDKQKSDGLKQLASQTESTLYMVLLASYTLLL 4131 Query: 1589 YRISNHKELVVGIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRXXXXXXXXXXXXX 1648 + S ++++VG P AG+ + ++G +N L TF Sbjct: 4132 SKYSGQEDIIVGSPIAGRPHADLEPIIGMFVNTLAMRNYPEKGKTFSQYLSEVKENALKA 4191 Query: 1649 XXXQDYSYASLMKELHSLDGSVHPPQINTMFNMDKSLETPDFTGMDVELLQSPVSYS--K 1706 QDY + +L+ +L+ P +TMF + + E DV P ++ K Sbjct: 4192 YEHQDYPFEALIDQLNIARDLSRNPLFDTMFVLQNT-EQEQLEINDVTFKPYPNGHTMAK 4250 Query: 1707 YDLSMNIVELDHELMIDFEYDPNLFDTQIITGWANYFNRILLAVL-QPD 1754 +DL++ VE + EY LF + I +F +++ +++ QP+ Sbjct: 4251 FDLTLTAVEEGASIQFTLEYLTALFKPETIERMMGHFEQLVDSIIKQPE 4299 Score = 131 bits (330), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 179/779 (22%), Positives = 310/779 (39%), Gaps = 121/779 (15%) Query: 1801 ILDKDMHPSPVGVPGEVYL-----AR--LTEPSLLAE----------QPSTSTGIMAMYT 1843 IL P+GVPGE+Y+ AR L P L E Q TG +A + Sbjct: 585 ILGAHHQIQPIGVPGELYVGGAGVARGYLNRPELTEEKFVEHLHVPGQKMYKTGDLARWL 644 Query: 1844 ADFEIKVIGHHSRLMSQNGRMINLDTIQEQLVLHPLIGHAAVTVKPSGTFQRDQKILAYI 1903 D I+ +G + G I + ++ + + AAV + + ++ AY Sbjct: 645 PDGRIEYLGRIDHQVKIRGYRIEIGEVEAAMFNLENVREAAVVAREDADGAK--QLYAYY 702 Query: 1904 TPRGTSIPKVREIKKFLLSRIPGNFIPSAFMVLDEIPLNSKGGINERLLPAFDEDKALRE 1963 G + ++ L +P IPS F+ L+ IPL S G I+ + LPA DE+ Sbjct: 703 V--GEPSLTAAQFREELSRELPNYMIPSRFIPLERIPLTSNGKIDLKALPAADENTRAEN 760 Query: 1964 EIMLPENETEERLAEIWRNVLNLELVNTNDDFFELGGNSLKASLLAFSIQKEFSTDISLR 2023 E + P N EE LA IW+ VL E + D+FF+ GG+S+K S+ S + + ++ Sbjct: 761 EYIAPRNTIEELLASIWQEVLGAERIGILDNFFDFGGDSIK-SIQVSSRLYQAGYKVDMK 819 Query: 2024 MLFEHPTVKGLAK------------AINGAGKSFLPEITPLGKKDWYPQSSSQKRLFAIE 2071 LF+HP++ L++ +NG K +TP+ + W+ E Sbjct: 820 HLFKHPSIAELSQFVAPVSRVADQGEVNGGTK-----LTPI--QHWF-----------FE 861 Query: 2072 QMGGAGTAYNITGILHVEGKLDPGRMEEAFQRLVKRHEPLRTSF---------------- 2115 Q YN +L+ G + +R+ H+ LR F Sbjct: 862 QKMPHAHHYNQAVMLYSAEGFKEGPLRRTMERIASHHDALRMIFEKTPDGYAPRITGTDE 921 Query: 2116 -ELLHDEPVQVIHDDIPFSISYSIAEDEDEPELVKRFILPFSLNQAPLFRVHIVSRSDHE 2174 EL H E + + P + +IA+ +E + L++ PL ++ + D + Sbjct: 922 SELFHLEVMNYKGETDP---AQAIADKANEIQ------SSMVLDKGPLMKLGLFQCPDGD 972 Query: 2175 HIVIMDMHHIIADGISANILCNDLISLYS----GENL--PGLEVQYKDYTALHNEMLSNE 2228 H++I +HH++ DG+S IL D S Y G+ + P + + ++ + Sbjct: 973 HLLIA-IHHLLIDGVSWRILLEDFASGYEQAERGQTIQFPQKTDSFPFWAGQLSKYAAET 1031 Query: 2229 RIRQQGEYWQQLLSDDIPSLTLPLDFPRPPVQSFDGACYSVTLDSDLTRG-LKVLSNRLK 2287 + ++ YW +L S I LP D D ++ + T LK ++ Sbjct: 1032 DMEEEIAYWTELSS--IKPQPLPKDTISEGSLLRDSEEVTIQWTKEETEQLLKQANHAYN 1089 Query: 2288 TTLYTLLLASYNILLSKYSNQEDIVIGSPVAGRF----NYSTNNMVGMFVNTL------- 2336 T + LLL S + + K++ E+IV+ GR + + +G F + Sbjct: 1090 TDINDLLLTSLGLAVHKWTGTEEIVVNLEGHGREPIIPDADISRTIGWFTSQYPVVLRME 1149 Query: 2337 AMRNQPAKHKTFQEFLLEVKENTLEAFENQDYPFEELISKLGIERDISRNPVFDVMFVLQ 2396 A +N + K +E L + + + +Y + IS + NP ++ Q Sbjct: 1150 AGKNLSQRIKIVKEGLRRIPDKGM------NYSIIKYISGHSEADSLQLNPEISFNYLGQ 1203 Query: 2397 -SLDLAVPDVHLDDIR--LNGYEFKNDVAKFDLILEVIENTENLTLNFEYCAKLFQESTI 2453 DL + + L+ E + A DL + E T +LTL+ Y +K ++ ST+ Sbjct: 1204 FDQDLKHQALRISPFSTGLSMNENQERTAVLDLNGMIAEGTLSLTLS--YSSKQYERSTM 1261 Query: 2454 IRMSERFLRILTTVVENC-----------NVLLSDIDLLPKEETDRLIYTFNDTATAYP 2501 + + L V+ +C ++LL DI + E+ + YP Sbjct: 1262 AQFARGLKESLQEVIAHCVSRQQTSLTPSDILLKDISIDELEQLLEQTRELGEAENIYP 1320 Score = 98.6 bits (244), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 95/437 (21%), Positives = 207/437 (47%), Gaps = 40/437 (9%) Query: 3580 AYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRFVYKKLHRPLQIVLGSSDFHLEFE 3639 +Y+ ++ ++G + ++ L ++F+ ++ +++ LRT F P+Q VL + F E+ Sbjct: 3908 SYNMLGLMTVEGKLDRDKLQQAFRTLILRHESLRTGFKMAD-GEPVQYVLDHAAFEAEW- 3965 Query: 3640 DITHMESSEKMAHMERLKALDREKRFDLVQGPLMRAILLKTGDSVYQMLWSFHHILMDGW 3699 + E A + + + + F L + PL+R L++ +++ HHI+ DG Sbjct: 3966 ----YQGEEDDADLYIRQFI---RPFHLDEPPLLRVGLIELQPDRGILMFDMHHIISDGT 4018 Query: 3700 CIGIVLKDMLEHYKQLNAGSRPSLETHQYRLYLDWLASKNK----EEAKVYWMQ-YLEDY 3754 + +++K+ + Y+ + P L QY+ Y W S+ + ++ + YW++ Y D Sbjct: 4019 SMSVLIKEFIRIYE---GETLPPLRI-QYKDYAVWQTSEARLQQIQKQEAYWLELYSGDV 4074 Query: 3755 KYKELLRK--EGTSKEFRLAVLDIKLEEKVRTAVTHVASSSGITINSFFQAVWGILLSKY 3812 L ++++F A + L+++ + +AS + T+ A + +LLSKY Sbjct: 4075 PVLHLPADYIRPSARDFAGATMHFTLDKQKSDGLKQLASQTESTLYMVLLASYTLLLSKY 4134 Query: 3813 DNAEDVVFGAVISGRSPEIEGIERMVGLFINTIPVR-VRLSGKTFHELAGEIQSSFISSE 3871 ED++ G+ I+GR P + +E ++G+F+NT+ +R GKTF + E++ + + + Sbjct: 4135 SGQEDIIVGSPIAGR-PHAD-LEPIIGMFVNTLAMRNYPEKGKTFSQYLSEVKENALKAY 4192 Query: 3872 QYGYVP-------LSDIQAWSHRDLINHVMVFENYPLDR-EIRDTDGQQMEYGFQIAGCE 3923 ++ P L+ + S L + + V +N ++ EI D + G +A Sbjct: 4193 EHQDYPFEALIDQLNIARDLSRNPLFDTMFVLQNTEQEQLEINDVTFKPYPNGHTMA--- 4249 Query: 3924 ILEHTNYDFSII-IEPGEDFIIRIVYNALAYDKETISILESYLLAIIGQVTACPQIEAGD 3982 +D ++ +E G + Y + ETI + + ++ + P+ E Sbjct: 4250 -----KFDLTLTAVEEGASIQFTLEYLTALFKPETIERMMGHFEQLVDSIIKQPEAELAR 4304 Query: 3983 VEVLSQEEKLKLMNVFN 3999 + ++++EE+ + +FN Sbjct: 4305 LNMMTKEEERDIQQLFN 4321 Score = 95.5 bits (236), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 79/333 (23%), Positives = 157/333 (47%), Gaps = 23/333 (6%) Query: 3557 DVYTMTPMQESMLFHALKNKRSDAYHEQCILDLKGDIIQELLNESFKLIVGKYDILRTRF 3616 DVY ++ +Q+ + +Y+ IL L+G + L +F+ ++ +++ LRT F Sbjct: 4922 DVYPVSSVQKMVYLSTQIEGGELSYNMPGILTLEGKLDMNRLQTAFQRLIQRHESLRTGF 4981 Query: 3617 VYKKLHRPLQIVLGSSDFHLEFEDITHMESSEKMAHMERLKALDREKRFDLVQGPLMRAI 3676 + P+Q++ +F +E T E E R FDL Q PL+RA Sbjct: 4982 EMVR-GEPVQVIKSQVEFSMERYKATADEVEECFRTFVR--------PFDLSQAPLLRAG 5032 Query: 3677 LLKTGDSVYQMLWSFHHILMDGWCIGIVLKDMLEHYKQLNAGSRPSLETHQYRLYLDWLA 3736 L++ ++ ++ HHI+ DG + I +++++ QL G + QY+ + +W Sbjct: 5033 LIELEQDLHIFMFDMHHIITDGASMNIFVEELI----QLYDGKELAPLRIQYKDFTEWKH 5088 Query: 3737 SKNKEE----AKVYWMQ-YLEDYKYKELLRKEGTS--KEFRLAVLDIKLEEKVRTAVTHV 3789 K + E + YW+ + E+ EL + + F + L++ V + + Sbjct: 5089 QKEQRERIKSQEEYWLGVFHEELPSFELPKDFARPPVRSFDGKRHNFTLDKTVTQGIKQL 5148 Query: 3790 ASSSGITINSFFQAVWGILLSKYDNAEDVVFGAVISGRSPEIEGIERMVGLFINTIPVRV 3849 +G T + + ILL+KY +D+V G I+GR P + +E ++G+F+NT+ +R Sbjct: 5149 EELTGTTAYMILFSAYSILLAKYSGQDDIVVGTPIAGR-PHAD-LEPIIGMFVNTLAIRT 5206 Query: 3850 R-LSGKTFHELAGEIQSSFISSEQYGYVPLSDI 3881 ++ KTF + E + + + + ++ P ++ Sbjct: 5207 APMAEKTFLDYITETKETMLKAFEHQEYPFEEL 5239 Score = 84.3 bits (207), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 87/422 (20%), Positives = 168/422 (39%), Gaps = 13/422 (3%) Query: 1340 QISLVIHSN-DTHGVVHHETVGLYLRGELNKAALETAYHKVLNRHESLRSTISADGNE-- 1396 Q ++ HS D + E L+GEL + + ++ + LR+ + N+ Sbjct: 2834 QKGMLFHSLLDEASSSYFEQASFDLQGELKIDWFKASLERLFETYAVLRTRFYSGWNDTP 2893 Query: 1397 -QIVASHANADIFFADILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHE 1455 QIV I FAD+ L ++AI ++ A FD PL+R+ + + Sbjct: 2894 LQIVYKTQTPQIHFADLRDIEEHLREDAIAAYQREDKAKGFDLARDPLMRIAIFRMEDRK 2953 Query: 1456 YLLALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQP 1515 Y L S HHI+ DGW L + +E+ YS G + P+SDY W R + Sbjct: 2954 YHLIWSFHHIVMDGWCLSLITKEVFDHYSALQEGREPEPLSAVPYSDYIEWLDRQDQGAA 3013 Query: 1516 KEKAAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYVLDIPLTAKLKAVSQSMKVS 1575 K Y + T ++ ++ A R D T +L+ ++ +V+ Sbjct: 3014 KRYWGGYLEGYKGETTLLHKIAQHEQKEYAYANLICR----FDHEQTKQLQQIANQHQVT 3069 Query: 1576 LFTVLLSAYKVLLYRISNHKELVVGIPTAGQMQM--GQKHLVGYCLNILPFSTTINPEMT 1633 L T++ + + VLL + S ++V G +G+ + ++G +N +P + + T Sbjct: 3070 LNTLIQTLWGVLLQKYSGSADVVFGSVVSGRPAEIPDVEQMIGLFINTIPVRIRCDEDST 3129 Query: 1634 FRXXXXXXXXXXXXXXXXQDYSYASLMKELHSLDGSVHPPQINTMFNMDKSLETPDFTGM 1693 F Y + + + I + + + E G Sbjct: 3130 FADTMQMVQQNALASQSYDTYPLYEIQAQTEQKQNLIDHIMIFENYPIGQQAEETGHHGT 3189 Query: 1694 DVELLQSPVS-YSKYDLSMNIVELDHELMIDFEYDPNLFDTQIITGWANYFNRILLAVL- 1751 ++ + + +S YDL++ ++ +L + F ++ N ++ + +F +++ VL Sbjct: 3190 ELNITNFHMQEHSHYDLNVVVIP-GKQLAVHFGFNKNEYEKSEVERLRGHFEKLMQQVLR 3248 Query: 1752 QP 1753 QP Sbjct: 3249 QP 3250 Score = 77.4 bits (189), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 91/377 (24%), Positives = 153/377 (40%), Gaps = 45/377 (11%) Query: 1397 QIVASHANADIFFADILADYSALGDEAINQALLKENAAAFDSVMGPLIRLRVLATARHEY 1456 QI+ F D+ + + I Q ++ FD G L+RL +L T Y Sbjct: 1386 QIIFKTKKIGFQFNDLREMKESQKEAMIQQYAREDKMRGFDLEKGALMRLFILRTDEKTY 1445 Query: 1457 LLALSAHHIIADGWSLIVFLQELAALYSTECTGTRSLLPTPTPFSDYAIWQKRMLESQPK 1516 S HHI+ DGW L + +E+ Y + + TP+S Y W R Q Sbjct: 1446 RFIWSFHHILMDGWCLPLITKEIFENYFALLQQKQPEQSSITPYSQYIEWLGR----QDA 1501 Query: 1517 EKAAAYWKNKFSVQTPAFELPSFRIRDAAGVRKGSRHRYV-----LDIP--LTAKLKAVS 1569 ++A AYW LP +D G RYV DI LT+K+K + Sbjct: 1502 KEATAYWDQYLEGYEEQTGLP----KDHHAAEDG---RYVPEKVTCDISSDLTSKMKRTA 1554 Query: 1570 QSMKVSLFTVLLSAYKVLLYRISNHKELVVGIPTAGQMQ--MGQKHLVGYCLNILPFSTT 1627 V+L T+L +A+ VLL + + +++V G +G+ + ++G +N +P Sbjct: 1555 GKHHVTLNTLLQTAWAVLLQKYNRSRDVVFGSVVSGRPAGIPNVETMIGLFINTIPVRFR 1614 Query: 1628 INPEMTFRXXXXXXXXXXXXXXXXQDYSYASLMKELHSL-DGSVHPPQINTM-------- 1678 TF Q+ + AS E H L D Q + Sbjct: 1615 CEAGTTF----------AGLMKEAQERAVASQQFETHPLYDIQARTTQKQDLITHLMIFE 1664 Query: 1679 -FNMDKSLET---PDFTGMDVELLQSPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQ 1734 + +D+ +E+ + T + + +Q + YD ++ ++ D E+ I FEY+ N+++ Sbjct: 1665 NYPVDQYMESIGRQNGTSITISNVQME-EQTNYDFNLTVIPGD-EMNISFEYNANVYERA 1722 Query: 1735 IITGWANYFNRILLAVL 1751 I +F +IL V+ Sbjct: 1723 SIERVREHFMQILHQVV 1739 Score = 60.1 bits (144), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/240 (21%), Positives = 107/240 (44%), Gaps = 25/240 (10%) Query: 1521 AYWKNKFSVQTPAFELPSFRIRDAAGV-RKGSRHRYV---LDIPLTAKLKAVSQSMKVSL 1576 YW+N F + P F+ D A + R G + + + L ++ ++ ++ ++ Sbjct: 9 TYWENLFDEEDGLSAFPYFKAADKASLARTGYQEKCICRSLSPEVSQRIMTMANHSDMAA 68 Query: 1577 FTVLLSAYKVLLYRISNHKELVVGIPTAGQMQMGQKHLVGYCLNILPFSTTINPEMTFRX 1636 + +LL+ + LLY+ ++ L++GIPT + + GQ + NI+ T++ E TF+ Sbjct: 69 YLILLAGIECLLYKYTDRTSLILGIPTVSKQKAGQSAVN----NIVLLKNTLSNESTFKT 124 Query: 1637 XXXXXXXXXXXXXXXQDYSYASLMKELHSLDGSVHPPQINTMFNMDK--SLETPDFTGMD 1694 Q+ + +++ L H P I+T+ ++++ S + + T D Sbjct: 125 VFGQLKEAVNDSLKNQNLPFRKMVRHLSVQYNDEHMPLIHTVVSLNEIHSKQCKEDTATD 184 Query: 1695 VELLQSPVSYSKYDLSMNIVELDHELMIDFEYDPNLFDTQIITGWANYFNRILLAVL-QP 1753 + +DL N + L Y+ NL+D + I ++ +++L +L QP Sbjct: 185 --------TLFHFDLENNGIHL------KLFYNGNLYDERYINQIVSHLDQLLSVILFQP 230 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.319 0.136 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 5,904,709,211 Number of extensions: 256896544 Number of successful extensions: 662276 Number of sequences better than 1.0e-05: 6158 Number of HSP's gapped: 632075 Number of HSP's successfully gapped: 10188 Length of query: 4011 Length of database: 757,237,578 Length adjustment: 146 Effective length of query: 3865 Effective length of database: 360,833,124 Effective search space: 1394620024260 Effective search space used: 1394620024260 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 136 (57.0 bits)