BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0557.0029.p (327 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value dbj|BAB07799.1| meso-diaminopimelate dehydrogenase [Bacillus sph... 443 e-123 ref|NP_783055.1| meso-diaminopimelate dehydrogenase [Clostridium... 417 e-115 dbj|BAA13523.1| D-2-hydroxyisocaproate dehydrogenase (DDH) [Cory... 320 3e-86 ref|NP_601818.2| D-2-hydroxyisocaproate dehydrogenase [Corynebac... 318 8e-86 ref|NP_739108.1| diaminopimelate dehydrogenase [Corynebacterium ... 305 8e-82 >dbj|BAB07799.1| meso-diaminopimelate dehydrogenase [Bacillus sphaericus] Length = 326 Score = 443 bits (1140), Expect = e-123, Method: Compositional matrix adjust. Identities = 207/325 (63%), Positives = 253/325 (77%) Query: 3 TTIKVGISGYGNLGRGVHQAIAQNPDMELVAIFTRRDPQQLQTPPGVHFEHISAADQYIG 62 + I+VGI GYGNLGRGV AI+QNPDMELVA+FTRRDP + + A+++ Sbjct: 2 SAIRVGIVGYGNLGRGVEFAISQNPDMELVAVFTRRDPSTVSVASNASVYLVDDAEKFQD 61 Query: 63 RIDVMILCGGSATDLPEQTPQLAAMFNTVDSFDTHAKIPEFFQSVNQAALGGGRLSVIST 122 IDVMILCGGSATDLPEQ P A FNT+DSFDTHAKIPEFF +V+ AA G++SVIS Sbjct: 62 DIDVMILCGGSATDLPEQGPHFAQWFNTIDSFDTHAKIPEFFDAVDAAAQKSGKVSVISV 121 Query: 123 GWDPGLFSMNRLLMEAVLPEGQEYTFWGPGVSQGHSDAIRRVPGVKAGVQYTVPVQAVID 182 GWDPGLFS+NR+L EAVLP G YTFWG G+SQGHSDA+RR+ GVK VQYT+P++ ++ Sbjct: 122 GWDPGLFSLNRVLGEAVLPVGTTYTFWGDGLSQGHSDAVRRIEGVKNAVQYTLPIKDAVE 181 Query: 183 GIRAGDTPKLETRQKHRRDCFVVAQEDADREQIRKAIVNMPNYFADYDTTVTFITQEQLA 242 +R G+ P+L TR+KH R+C+VV +E AD ++ + IV MPNYF +Y+TTV FI++++ Sbjct: 182 RVRNGENPELTTREKHARECWVVLEEGADAPKVEQEIVTMPNYFDEYNTTVNFISEDEFN 241 Query: 243 AEHSGMPHGGFVIRSGVSGNGSKQIAEFGLKLESNPEFTASVLVAYARAAFRLSQEGQRG 302 A H+GMPHGGFVIRSG SG KQI EF LKLESNP FT+SVLVAYARAA RLSQ G++G Sbjct: 242 ANHTGMPHGGFVIRSGESGANDKQILEFSLKLESNPNFTSSVLVAYARAAHRLSQAGEKG 301 Query: 303 AKTVFDIPLGYLSPKSAEELRRGLL 327 AKTVFDIP G LSPKSA +LR+ LL Sbjct: 302 AKTVFDIPFGLLSPKSAAQLRKELL 326 >ref|NP_783055.1| meso-diaminopimelate dehydrogenase [Clostridium tetani E88] gb|AAO36992.1| meso-diaminopimelate dehydrogenase [Clostridium tetani E88] Length = 326 Score = 417 bits (1071), Expect = e-115, Method: Compositional matrix adjust. Identities = 191/327 (58%), Positives = 252/327 (77%), Gaps = 1/327 (0%) Query: 1 VNTTIKVGISGYGNLGRGVHQAIAQNPDMELVAIFTRRDPQQLQTPPGVHFEHISAADQY 60 +N+ I++GI GYGN+G+GV +AI QN DMEL AIFTRRD ++ + HIS + Y Sbjct: 1 MNSKIRIGIVGYGNIGKGVEKAIKQNDDMELEAIFTRRDINKVDSNNS-KLVHISRLELY 59 Query: 61 IGRIDVMILCGGSATDLPEQTPQLAAMFNTVDSFDTHAKIPEFFQSVNQAALGGGRLSVI 120 +DVMILCGGSATDL EQ P +A+ FNTVDSFD H +IP+ F+ +++ + G +S+I Sbjct: 60 KDTVDVMILCGGSATDLVEQGPMIASQFNTVDSFDNHGRIPQHFERMDEISKKAGNISLI 119 Query: 121 STGWDPGLFSMNRLLMEAVLPEGQEYTFWGPGVSQGHSDAIRRVPGVKAGVQYTVPVQAV 180 STGWDPGLFS+NRLL E++LP+G+ +TFWG GVSQGHSDAIRRV GVK G+QYT+P++ Sbjct: 120 STGWDPGLFSLNRLLGESILPKGKTHTFWGKGVSQGHSDAIRRVQGVKNGIQYTIPIKGA 179 Query: 181 IDGIRAGDTPKLETRQKHRRDCFVVAQEDADREQIRKAIVNMPNYFADYDTTVTFITQEQ 240 +D R+G+ TR+KH R C+VV +E+AD ++I + I MP+YFADY+TTV FIT+E+ Sbjct: 180 LDKARSGEQCDFTTREKHERVCYVVPEENADLKKIEQDIKTMPDYFADYNTTVHFITEEE 239 Query: 241 LAAEHSGMPHGGFVIRSGVSGNGSKQIAEFGLKLESNPEFTASVLVAYARAAFRLSQEGQ 300 L H+G+PHGGFVIRSG + G+KQ+ EF L LESN EFT+SVLVAY+RA ++LS+EG+ Sbjct: 240 LKLNHAGLPHGGFVIRSGNTQGGAKQVMEFNLNLESNAEFTSSVLVAYSRAIYKLSKEGK 299 Query: 301 RGAKTVFDIPLGYLSPKSAEELRRGLL 327 +GA TV DIP YLSPK+ EELR+ LL Sbjct: 300 KGAVTVLDIPFSYLSPKTPEELRKELL 326 >dbj|BAA13523.1| D-2-hydroxyisocaproate dehydrogenase (DDH) [Corynebacterium glutamicum] Length = 320 Score = 320 bits (820), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 156/320 (48%), Positives = 216/320 (67%), Gaps = 6/320 (1%) Query: 3 TTIKVGISGYGNLGRGVHQAIAQNPDMELVAIFTRRDPQQLQTPPGVHFEHISAADQYIG 62 T I+V I GYGNLGR V + IA+ PDM+LV IF+RR +TP F+ ++ D++ Sbjct: 2 TNIRVAIVGYGNLGRSVEKLIAKQPDMDLVGIFSRRATLDTKTPV---FD-VADVDKHAD 57 Query: 63 RIDVMILCGGSATDLPEQTPQLAAMFNTVDSFDTHAKIPEFFQSVNQAALGGGRLSVIST 122 +DV+ LC GSATD+PEQ P+ A TVD++D H IP Q +N+AA G ++++ST Sbjct: 58 DVDVLFLCMGSATDIPEQAPKFAQFACTVDTYDNHRDIPRHRQVMNEAATAAGNVALVST 117 Query: 123 GWDPGLFSMNRLLMEAVLPEGQEYTFWGPGVSQGHSDAIRRVPGVKAGVQYTVPVQAVID 182 GWDPG+FS+NR+ AVL E Q++TFWGPG+SQGHSDA+RR+PGV+ VQYT+P + ++ Sbjct: 118 GWDPGMFSINRVYAAAVLAEHQQHTFWGPGLSQGHSDALRRIPGVQKAVQYTLPSEEALE 177 Query: 183 GIRAGDTPKLETRQKHRRDCFVVAQEDADREQIRKAIVNMPNYFADYDTTVTFITQEQLA 242 R G+ L +Q H+R CFVVA + AD E+I I MP+YF Y+ V FI + Sbjct: 178 KARRGEAGDLTGKQTHKRQCFVVA-DAADHERIENDIRTMPDYFVGYEVEVNFIDEATFD 236 Query: 243 AEHSGMPHGGFVIRSGVSGNGSKQIAEFGLKLESNPEFTASVLVAYARAAFRLSQEGQRG 302 AEH+GMPHGG VI +G +G G E+ LKL+ NP+FTAS +A+ RAA R+ Q+GQ G Sbjct: 237 AEHTGMPHGGHVITTGDTG-GFNHTVEYILKLDRNPDFTASSQIAFGRAAHRMKQQGQSG 295 Query: 303 AKTVFDIPLGYLSPKSAEEL 322 A TV ++ LSP++ ++L Sbjct: 296 AFTVLEVAPYLLSPENLDDL 315 >ref|NP_601818.2| D-2-hydroxyisocaproate dehydrogenase [Corynebacterium glutamicum ATCC 13032] sp|P04964|DDH_CORGL Meso-diaminopimelate D-dehydrogenase pir||S07384 diaminopimelate dehydrogenase (EC 1.4.1.16) - Corynebacterium glutamicum pdb|1DAP|A Chain A, C. Glutamicum Dap Dehydrogenase In Complex With Nadp+ pdb|1DAP|B Chain B, C. Glutamicum Dap Dehydrogenase In Complex With Nadp+ pdb|3DAP|A Chain A, C. Glutamicum Dap Dehydrogenase In Complex With Nadp+ And The Inhibitor 5s-Isoxazoline pdb|3DAP|B Chain B, C. Glutamicum Dap Dehydrogenase In Complex With Nadp+ And The Inhibitor 5s-Isoxazoline pdb|2DAP| C. Glutamicum Dap Dehydrogenase In Complex With Dap pdb|1F06|A Chain A, Three Dimensional Structure Of The Ternary Complex Of Corynebacterium Glutamicum Diaminopimelate Dehydrogenase Nadph-L-2-Amino-6-Methylene-Pimelate pdb|1F06|B Chain B, Three Dimensional Structure Of The Ternary Complex Of Corynebacterium Glutamicum Diaminopimelate Dehydrogenase Nadph-L-2-Amino-6-Methylene-Pimelate emb|CAA68346.1| unnamed protein product [Corynebacterium glutamicum] dbj|BAC00011.1| Meso-diaminopimelate d-dehydrogenase [Corynebacterium glutamicum ATCC 13032] emb|CAF21279.1| MESO-DIAMINOPIMELATE DEHYDROGENASE [Corynebacterium glutamicum ATCC 13032] Length = 320 Score = 318 bits (816), Expect = 8e-86, Method: Compositional matrix adjust. Identities = 155/320 (48%), Positives = 216/320 (67%), Gaps = 6/320 (1%) Query: 3 TTIKVGISGYGNLGRGVHQAIAQNPDMELVAIFTRRDPQQLQTPPGVHFEHISAADQYIG 62 T I+V I GYGNLGR V + IA+ PDM+LV IF+RR +TP F+ ++ D++ Sbjct: 2 TNIRVAIVGYGNLGRSVEKLIAKQPDMDLVGIFSRRATLDTKTPV---FD-VADVDKHAD 57 Query: 63 RIDVMILCGGSATDLPEQTPQLAAMFNTVDSFDTHAKIPEFFQSVNQAALGGGRLSVIST 122 +DV+ LC GSATD+PEQ P+ A TVD++D H IP Q +N+AA G ++++ST Sbjct: 58 DVDVLFLCMGSATDIPEQAPKFAQFACTVDTYDNHRDIPRHRQVMNEAATAAGNVALVST 117 Query: 123 GWDPGLFSMNRLLMEAVLPEGQEYTFWGPGVSQGHSDAIRRVPGVKAGVQYTVPVQAVID 182 GWDPG+FS+NR+ AVL E Q++TFWGPG+SQGHSDA+RR+PGV+ VQYT+P + ++ Sbjct: 118 GWDPGMFSINRVYAAAVLAEHQQHTFWGPGLSQGHSDALRRIPGVQKAVQYTLPSEDALE 177 Query: 183 GIRAGDTPKLETRQKHRRDCFVVAQEDADREQIRKAIVNMPNYFADYDTTVTFITQEQLA 242 R G+ L +Q H+R CFVVA + AD E+I I MP+YF Y+ V FI + Sbjct: 178 KARRGEAGDLTGKQTHKRQCFVVA-DAADHERIENDIRTMPDYFVGYEVEVNFIDEATFD 236 Query: 243 AEHSGMPHGGFVIRSGVSGNGSKQIAEFGLKLESNPEFTASVLVAYARAAFRLSQEGQRG 302 +EH+GMPHGG VI +G +G G E+ LKL+ NP+FTAS +A+ RAA R+ Q+GQ G Sbjct: 237 SEHTGMPHGGHVITTGDTG-GFNHTVEYILKLDRNPDFTASSQIAFGRAAHRMKQQGQSG 295 Query: 303 AKTVFDIPLGYLSPKSAEEL 322 A TV ++ LSP++ ++L Sbjct: 296 AFTVLEVAPYLLSPENLDDL 315 >ref|NP_739108.1| diaminopimelate dehydrogenase [Corynebacterium efficiens YS-314] dbj|BAB88824.1| diaminopimelate dehydrogenase [Corynebacterium efficiens] dbj|BAC19308.1| diaminopimelate dehydrogenase [Corynebacterium efficiens YS-314] Length = 320 Score = 305 bits (782), Expect = 8e-82, Method: Compositional matrix adjust. Identities = 148/320 (46%), Positives = 210/320 (65%), Gaps = 6/320 (1%) Query: 3 TTIKVGISGYGNLGRGVHQAIAQNPDMELVAIFTRRDPQQLQTPPGVHFEHISAADQYIG 62 + I+ I GYGNLG+ V + I Q PDMELV IF+RRD TP +++ +++ G Sbjct: 2 SKIRAAIVGYGNLGKSVEKLIVQQPDMELVGIFSRRDTLDTDTP----VFNVAETEKHTG 57 Query: 63 RIDVMILCGGSATDLPEQTPQLAAMFNTVDSFDTHAKIPEFFQSVNQAALGGGRLSVIST 122 +D++ LC GSATD+PEQ P AA TVD++D H IP Q +++AA G +SV++T Sbjct: 58 DVDLLFLCMGSATDIPEQAPGFAAFACTVDTYDNHRDIPRHRQVMDEAARAAGNVSVVAT 117 Query: 123 GWDPGLFSMNRLLMEAVLPEGQEYTFWGPGVSQGHSDAIRRVPGVKAGVQYTVPVQAVID 182 GWDPG+FS+NR+ A+L + Q++TFWGPG+SQGHSDA+RR+ GV+ VQYT+P + ++ Sbjct: 118 GWDPGMFSINRVYGAALLADHQQHTFWGPGLSQGHSDALRRIDGVEKAVQYTLPSEDALE 177 Query: 183 GIRAGDTPKLETRQKHRRDCFVVAQEDADREQIRKAIVNMPNYFADYDTTVTFITQEQLA 242 R G+ L +Q H+R CFVVA E ++ E+I I M +YF Y+ V FI + Sbjct: 178 KARRGEAEGLTGKQTHKRQCFVVAPE-SEHERIENEIRTMADYFVGYEVEVNFIDEATFD 236 Query: 243 AEHSGMPHGGFVIRSGVSGNGSKQIAEFGLKLESNPEFTASVLVAYARAAFRLSQEGQRG 302 +EH+GMPHGG VI +G +G G E+ LKL+ NP+FTAS +A+ RAA+RL + GQ G Sbjct: 237 SEHTGMPHGGHVITTGDTG-GFHHTVEYTLKLDRNPDFTASSQIAFGRAAYRLKEAGQAG 295 Query: 303 AKTVFDIPLGYLSPKSAEEL 322 A TV ++ LSP ++L Sbjct: 296 AFTVLEVAPYLLSPTPLDDL 315 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.319 0.136 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 479,004,452 Number of extensions: 19326237 Number of successful extensions: 43979 Number of sequences better than 1.0e-05: 7 Number of HSP's gapped: 43966 Number of HSP's successfully gapped: 7 Length of query: 327 Length of database: 757,237,578 Length adjustment: 126 Effective length of query: 201 Effective length of database: 415,135,104 Effective search space: 83442155904 Effective search space used: 83442155904 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 126 (53.1 bits)