BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0548.0039.p (976 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_349607.1| Zn-dependent peptidase, insulinase family [Clos... 1013 0.0 ref|NP_781471.1| Zn-dependent peptidase, insulinase family [Clos... 880 0.0 ref|NP_562318.1| probable zinc metalloprotease [Clostridium perf... 813 0.0 ref|NP_348280.1| Zn-dependent metalloprotease, insulinase family... 723 0.0 ref|ZP_00129289.1| COG1026: Predicted Zn-dependent peptidases, i... 587 e-166 >ref|NP_349607.1| Zn-dependent peptidase, insulinase family [Clostridium acetobutylicum] pir||H97269 Zn-dependent peptidase, insulinase family [imported] - Clostridium acetobutylicum gb|AAK80947.1| Zn-dependent peptidase, insulinase family [Clostridium acetobutylicum] Length = 976 Score = 1013 bits (2618), Expect = 0.0, Method: Compositional matrix adjust. Identities = 479/973 (49%), Positives = 697/973 (71%), Gaps = 4/973 (0%) Query: 1 MSSLKTGQIYSGFQVVHEEYIREIESTVFTMEHQPSGARLLFVQNQDDNKVFSISFRTPP 60 M+ K IY GF+ V EE I EI S F EH SGARLL++QN+D NKVFSISFRTPP Sbjct: 1 MNCFKKDSIYHGFKFVSEEDINEINSKAFMFEHVKSGARLLYLQNEDKNKVFSISFRTPP 60 Query: 61 GDSTGVFHILEHSVLCGSDKYPVKEPFVELLKSSMKTFLNAFTFADKTMYPVASRNHQDF 120 DSTGVFHILEHSVLCGSDKYPVKEPFVELLK S+ TFLNAFTF+DKTMYPVAS+N +DF Sbjct: 61 KDSTGVFHILEHSVLCGSDKYPVKEPFVELLKGSLNTFLNAFTFSDKTMYPVASQNDKDF 120 Query: 121 SNLMEVYLDSVFKPNIYRQQEIFEQEGWHYDLHHAEDELIYKGVVYNEMKGSYSSPVTVL 180 NLM+VYLD+VF PNIY+ +EIF+QEGWHY+L++ ++ + YKGVVYNEMKG++SSP VL Sbjct: 121 LNLMDVYLDAVFHPNIYKYEEIFQQEGWHYELNNKDENISYKGVVYNEMKGAFSSPEGVL 180 Query: 181 IDRIKKSLYPDTVYRYSSGGDPQDIPALTYEQFLAAHSQYYHPSNSYFYLYGDVNIEERL 240 + +I+ SL+PD Y + SGGDP DIP LTY+ FL +H +YY PSNSY YLYGD++I+E+L Sbjct: 181 MRKIQNSLFPDNTYGFESGGDPDDIPDLTYDAFLDSHKKYYSPSNSYIYLYGDMDIDEKL 240 Query: 241 EFIHQEYLKSYNRDDFDTAIPLQQPTG-MTELTAEYPILETETAADKTYLSMNYVIGTAL 299 ++I +EYLK+Y+R + D+ I Q+P G + E + EYPIL+ E DKTYLS+N+V+ + Sbjct: 241 KYIDEEYLKNYDRIEVDSKIEPQKPIGKLVESSHEYPILQDEGEKDKTYLSLNFVVSSPT 300 Query: 300 DRELNLAFAILKNMLMDSNAAPLKRALLESGLGKDVFAFYSDSMIQPLLGITLTHSNPSA 359 D E LAF +L+ +L++S AAPLK+A++++GLGKDVF Y + ++Q + + +SN Sbjct: 301 DNEKYLAFDMLEYILLESEAAPLKKAIIKAGLGKDVFGIYDNGIMQTYFSVIVKNSNEER 360 Query: 360 KDAFLDLIRTTLSRLAADGLDEKLVLAAVNSKEFELREADFIQYPKGLTYNIEVMKSWLY 419 K+ F L+ TL+ L +G+D+KL+ AA+N +EFELREADF YP+GL Y+I+ M SWLY Sbjct: 361 KEEFKKLVFDTLNDLVKNGIDKKLIEAAINIREFELREADFKSYPRGLGYSIKTMDSWLY 420 Query: 420 DGSPATHLEYEAVFASIREQCADRYFERLIETYLLNSDHCSVVILQPSAALAAEKETSIR 479 D +P +L +E +I++ + YFE+LIE YL+NS+H S+VI++PS + +K Sbjct: 421 DANPTNNLRFEDALKNIKKSLTENYFEKLIEDYLINSNHSSLVIVKPSKTVEVKKSKKES 480 Query: 480 RQLAEYKASLSPEQLGQLVQRTQNLLDRQSRPDAAEDLRKLPKLSLQDINRSVPPQVHTQ 539 +L+ K+SLS E+L +++ T+ L +RQ+ D+ EDLRK+P LSL+D+N+ V ++ + Sbjct: 481 EELSSLKSSLSDEELNKIISDTKKLRERQTSEDSEEDLRKIPMLSLKDVNKEV-EKLPLE 539 Query: 540 EYMLEGIKLIHHEILTNKIAYIKLYWDTGVLAAEQIPYLVLLARALGQLETAAYSIEELT 599 E + IK+++H + TNKI Y+++Y+++GV+ + +PYL LL LG++ T Y E+L Sbjct: 540 EREEDKIKVLYHNVFTNKILYLRMYFESGVVKYDDLPYLGLLENILGKVNTEKYKYEDLA 599 Query: 600 GEIGIKTGGIRFQNEVFGANKNSHAGYQPKFSARIKVMEGSISESLTLLHELLYGSNLDN 659 EI IKTG I F+N +F + K+ Y KF + KV+ + ++ L+ E++Y S D+ Sbjct: 600 NEINIKTGDISFENNLFTS-KDDDKDYTTKFVCKTKVIMDKVGDAFQLIDEIIYHSLFDD 658 Query: 660 FTKLQEIVRREASHMESVLNQKGNEIAASRLLSYFSDMGAYEEQLGGVAYYRFIRELADG 719 +++EI++ S +E ++NQ GN IAA RL SYFS G Y E+L G+++Y+FI L + Sbjct: 659 EKRIKEIIQEMRSRLEMIINQSGNSIAAIRLKSYFSPSGEYSERLNGISFYKFICNLDEN 718 Query: 720 IDLQAEQLSDTLKGICAALFNKRNLTLSVTGTSDIYAEFAAHLAQLDIQDQQVEPQP-KL 778 + +++ + LKGIC +FNK N+ +SVTG ++Y +F L ++ ++ +V + + Sbjct: 719 FSEKFDEVKNKLKGICDTIFNKDNVIISVTGNDEVYNKFKEQLPKIKLKSFEVPAKSEEY 778 Query: 779 KAQNHAGNEGFMSASQVQYVVKGYDFSKLGFVYSGKMQVLKKILSLTYLWNTVRVKGGAY 838 + NEG +++S+VQY KG++F +LG+ YSGKM+VLK I+SL+YLWN VRV GGAY Sbjct: 779 NKVAQSNNEGLITSSKVQYAAKGFNFRRLGYDYSGKMKVLKSIISLSYLWNNVRVMGGAY 838 Query: 839 GGNLLLRRDGVLLFTSYRDPNLQETLEVYDQAYRYAESFEADEEEMTQAIIGTLAMFEQP 898 G + ++R+G +LF SYRDPNL ETL++YD+ Y+Y E+F AD+ EMT+ I+GT++ +QP Sbjct: 839 GCSAYIQRNGSILFASYRDPNLTETLKIYDEVYKYIENFNADDYEMTKYILGTISSIDQP 898 Query: 899 LSPSALRRRADRHYFEQITVEELQQERNEIFSATPEDIRHYARLLKTVTEQNFFSVVGND 958 L P + +++D +YF ++T E+LQ+ER+EI S E+I+ Y++LLK V EQN+ V+GND Sbjct: 899 LLPKQIGQKSDSYYFNKLTYEDLQKERDEILSTKKEEIKSYSKLLKDVMEQNYICVLGND 958 Query: 959 SKMKPAQAIFGSL 971 K+ + IFG L Sbjct: 959 VKITENKDIFGRL 971 >ref|NP_781471.1| Zn-dependent peptidase, insulinase family [Clostridium tetani E88] gb|AAO35408.1| Zn-dependent peptidase, insulinase family [Clostridium tetani E88] Length = 973 Score = 880 bits (2274), Expect = 0.0, Method: Compositional matrix adjust. Identities = 448/975 (45%), Positives = 632/975 (64%), Gaps = 17/975 (1%) Query: 4 LKTGQIYSGFQVVHEEYIREIESTVFTMEHQPSGARLLFVQNQDDNKVFSISFRTPPGDS 63 L+ G+IY+GF+++ + + EI S +H + A+LL + N+DDNKVF+ISFRTPP DS Sbjct: 2 LEIGKIYNGFKLIEKSRLEEINSEALVFQHVKTEAKLLKLINEDDNKVFAISFRTPPEDS 61 Query: 64 TGVFHILEHSVLCGSDKYPVKEPFVELLKSSMKTFLNAFTFADKTMYPVASRNHQDFSNL 123 TGV HILEHSVLCGS K+P+KEPFVEL+K S+ TFLNA TF DKTMYP+ASRN QDF NL Sbjct: 62 TGVAHILEHSVLCGSRKFPLKEPFVELIKGSLNTFLNAMTFPDKTMYPIASRNKQDFFNL 121 Query: 124 MEVYLDSVFKPNIYRQQEIFEQEGWHYDLHHAEDELIYKGVVYNEMKGSYSSPVTVLIDR 183 M+VYLD+VF PNIY Q EIF QEGWHY++ + +++ YKGVVYNEMKG++SSP ++L + Sbjct: 122 MDVYLDAVFYPNIYEQPEIFMQEGWHYEIENKNEDIEYKGVVYNEMKGAFSSPESILSRK 181 Query: 184 IKKSLYPDTVYRYSSGGDPQDIPALTYEQFLAAHSQYYHPSNSYFYLYGDVNIEERLEFI 243 I ++LYPDT Y SGGDP IP LTY +F+ H +YYHPSNSY YLYGD + E L+FI Sbjct: 182 IMETLYPDTAYGVESGGDPDYIPELTYSKFIEFHKRYYHPSNSYIYLYGDGDTLEELKFI 241 Query: 244 HQEYLKSYNRDDFDTAIPLQQP-TGMTELTAEYPILETETAADKTYLSMNYVIGTALDRE 302 + YLK +++ D+ I Q+P M E+ EYPIL E DKT+LS+N I + ++E Sbjct: 242 EENYLKDFSKLKIDSTIEEQKPFDSMKEIKVEYPILPDEKEEDKTFLSLNLSIEKSTNKE 301 Query: 303 LNLAFAILKNMLMDSNAAPLKRALLESGLGKDVFAFYSDSMIQPLLGITLTHSNPSAKDA 362 L LAF IL+++L+++ AAPLKRAL++SG+GKDVF Y +S++QP I + +SN K+ Sbjct: 302 LYLAFDILEHLLLETQAAPLKRALIQSGIGKDVFGSYENSILQPFFSIIVKNSNADKKEE 361 Query: 363 FLDLIRTTLSRLAADGLDEKLVLAAVNSKEFELREADFIQYPKGLTYNIEVMKSWLYDGS 422 F +++ TL L DG+D+KLV A++N KEF LREADF YP GL Y I+ M SWLYD Sbjct: 362 FKNVVMNTLKNLVKDGIDKKLVEASINIKEFGLREADFGGYPTGLIYGIKCMDSWLYDKE 421 Query: 423 PATHLEYEAVFASIREQC-ADRYFERLIETYLLNSDHCSVVILQPSAALAAEKETSIRRQ 481 P HL YE I+ + YFE LIE YLLN+ H S++I+ P+ +A +K IR Sbjct: 422 PLMHLRYEEQLNKIKTNALNNNYFENLIEKYLLNNSHSSLLIVSPAKGIAEKKNEKIRED 481 Query: 482 LAEYKASLSPEQLGQLVQRTQNLLDRQSRPDAAEDLRKLPKLSLQDINR---SVPPQVHT 538 L YK SLS + L +++ T+ L +RQ D+ E+L+K+P LS++DI++ +P +V Sbjct: 482 LKNYKESLSEQDLDNIIKETKLLKERQITQDSEENLKKIPLLSIEDIDKDTEKLPIEVRE 541 Query: 539 QEYMLEGIKLIHHEILTNKIAYIKLYWDTGVLAAEQIPYLVLLARALGQLETAAYSIEEL 598 + + IK++ H I TNKIAY+ LY++ + E IPY LL+ +G+++T YS EEL Sbjct: 542 E----KDIKVLKHNIFTNKIAYVNLYFNICNVPQEFIPYAGLLSGIIGKVDTKNYSYEEL 597 Query: 599 TGEIGIKTGGIRFQNEVFGANKNSHAGYQPKFSARIKVMEGSISESLTLLHELLYGSNLD 658 + EI I TGGI +++ +N + P F R K M + + LL E L S Sbjct: 598 SKEINIYTGGISSSVDIY-SNSKKVDKFIPMFKVRSKSMIDKLPKLFELLKEELMHSIFK 656 Query: 659 NFTKLQEIVRREASHMESVLNQKGNEIAASRLLSYFSDMGAYEEQLGGVAYYRFIRELAD 718 + +++E++ S +E ++ KG+ IAA R+ SYFS Y E++ G+ Y FI EL Sbjct: 657 DHNRIKELISEMKSRIEMIIFDKGHLIAAGRVGSYFSAATDYSEKVSGLKLYNFICELER 716 Query: 719 GIDLQAEQLSDTLKGICAALFNKRNLTLSVTGTSDIYAEFAAHLAQLDIQ---DQQVEPQ 775 D ++ + LK +C +FNK NLT+SVT + Y EF + L + ++ + Sbjct: 717 --DFNGNEIENKLKELCKIIFNKENLTVSVTMEEEDYEEFKKNFDILYNELGNNKMINCN 774 Query: 776 PKLKAQNHAGNEGFMSASQVQYVVKGYDFSKLGFVYSGKMQVLKKILSLTYLWNTVRVKG 835 + K Q NEG M++ +VQY KGY+F KLG+ YSG M+VLK I+S YLWN VRV+G Sbjct: 775 YEFKEQQL--NEGLMTSGKVQYNAKGYNFKKLGYEYSGAMRVLKSIVSYDYLWNKVRVQG 832 Query: 836 GAYGGNLLLRRDGVLLFTSYRDPNLQETLEVYDQAYRYAESFEADEEEMTQAIIGTLAMF 895 GAYG + R+G + FTSYRDP L+ TL YD Y E+F DE E+T+ IIGT++ Sbjct: 833 GAYGCFGVFNRNGNMFFTSYRDPALKNTLSAYDGMKNYIENFSGDEREITKYIIGTISDI 892 Query: 896 EQPLSPSALRRRADRHYFEQITVEELQQERNEIFSATPEDIRHYARLLKTVTEQNFFSVV 955 + PL+PS +A YF I+ E+LQ+ER EI EDIR ++L+ ++N+ V+ Sbjct: 893 DTPLTPSMKGEKAAAGYFSDISYEDLQKEREEILDVKIEDIRTLSKLVDDCMKKNYICVL 952 Query: 956 GNDSKMKPAQAIFGS 970 G++ K++ + +F + Sbjct: 953 GSEEKIRENKEMFNN 967 >ref|NP_562318.1| probable zinc metalloprotease [Clostridium perfringens] sp|Q46205|HYPA_CLOPE HypA protein dbj|BAB81108.1| probable zinc metalloprotease [Clostridium perfringens str. 13] Length = 973 Score = 813 bits (2100), Expect = 0.0, Method: Compositional matrix adjust. Identities = 406/976 (41%), Positives = 613/976 (62%), Gaps = 6/976 (0%) Query: 3 SLKTGQIYSGFQVVHEEYIREIESTVFTMEHQPSGARLLFVQNQDDNKVFSISFRTPPGD 62 + K IYSGF++++ E + EI EH+ + A+L+ + ++DDNK F+I FRTPP + Sbjct: 2 NFKENNIYSGFKLLNIENLNEIGGVGLRFEHEKTKAKLIKILSEDDNKCFAIGFRTPPEN 61 Query: 63 STGVFHILEHSVLCGSDKYPVKEPFVELLKSSMKTFLNAFTFADKTMYPVASRNHQDFSN 122 STGV HILEHSVLCGS K+ KEPFVELLK S+ TFLNA T+ DKT+YPVASRN +DF N Sbjct: 62 STGVPHILEHSVLCGSRKFNTKEPFVELLKGSLNTFLNAMTYPDKTIYPVASRNEKDFMN 121 Query: 123 LMEVYLDSVFKPNIYRQQEIFEQEGWHYDLHHAEDELIYKGVVYNEMKGSYSSPVTVLID 182 LM+VYLD+V PNIY+ +EIF QEGWHY + + EDEL Y GVVYNEMKG+YSSP ++L Sbjct: 122 LMDVYLDAVLYPNIYKHKEIFMQEGWHYYIENKEDELKYNGVVYNEMKGAYSSPDSILYR 181 Query: 183 RIKKSLYPDTVYRYSSGGDPQDIPALTYEQFLAAHSQYYHPSNSYFYLYGDVNIEERLEF 242 +I +++YPDT Y SSGGDP +IP LTYE+F+ H +YYHPSNSY +LYG+ + E+ LEF Sbjct: 182 KIPQTIYPDTCYALSSGGDPDEIPNLTYEEFVEFHKKYYHPSNSYIFLYGNGDTEKELEF 241 Query: 243 IHQEYLKSYNRDDFDTAIPLQQP-TGMTELTAEYPILETETAADKTYLSMNYVIGTALDR 301 I++EYLK++ + D+ I Q+ M E + Y I E+E K+Y S+N+VIG A D Sbjct: 242 INEEYLKNFEYKEIDSEIKEQKSFESMKEESFTYGIAESEDLNHKSYYSLNFVIGDATDG 301 Query: 302 ELNLAFAILKNMLMDSNAAPLKRALLESGLGKDVFAFYSDSMIQPLLGITLTHSNPSAKD 361 E LAF +L +L S AAPLK+AL+++G+GK V + +S Q + + ++ + ++ Sbjct: 302 EKGLAFDVLAYLLTRSTAAPLKKALIDAGIGKAVSGDFDNSTKQSAFTVLVKNAELNKEE 361 Query: 362 AFLDLIRTTLSRLAADGLDEKLVLAAVNSKEFELREADFIQYPKGLTYNIEVMKSWLYDG 421 F ++ TL L +G+D++L+ A++N EFELRE D+ YP GL Y ++VM SWLYDG Sbjct: 362 EFKKVVMDTLKDLVENGIDKELIEASINRVEFELREGDYGSYPNGLIYYLKVMDSWLYDG 421 Query: 422 SPATHLEYEAVFASIREQCADRYFERLIETYLLNSDHCSVVILQPSAALAAEKETSIRRQ 481 P HLEYE I+ YFE LIE Y++N+ H S+V L P + +K ++++ Sbjct: 422 DPYVHLEYEKNLEKIKSALTSNYFEDLIERYMINNTHSSLVSLHPEKGINEKKSAELKKK 481 Query: 482 LAEYKASLSPEQLGQLVQRTQNLLDRQSRPDAAEDLRKLPKLSLQDINRSVPPQVHTQEY 541 L E K S + L +++ + L +RQS PD EDL +P LSL+DI++ ++ T+E Sbjct: 482 LEEIKNSFDEKTLNEIIDNCKKLKERQSTPDKKEDLESIPMLSLEDIDKEA-TKIPTEEK 540 Query: 542 MLEGIKLIHHEILTNKIAYIKLYWDTGVLAAEQIPYLVLLARALGQLETAAYSIEELTGE 601 ++GI +HH+ TNKI Y+ +++T + + IPY+ LL LG+ T Y +L+ Sbjct: 541 EIDGITTLHHDFHTNKIDYVNFFFNTNSVPEDLIPYVGLLCDILGKCGTENYDYSKLSNA 600 Query: 602 IGIKTGGIRFQNEVFGANKNSHAGYQPKFSARIKVMEGSISESLTLLHELLYGSNLDNFT 661 I I TGGI F F AN + ++P K + ++++ L+ E++ ++LD+ Sbjct: 601 INISTGGISFGAITF-ANLKKNNEFRPYLEISYKALSSKTNKAIELVDEIVNHTDLDDMD 659 Query: 662 KLQEIVRREASHMESVLNQKGNEIAASRLLSYFSDMGAYEEQLGGVAYYRFIRELADGID 721 ++ +I+R + + +E + G+ IA ++LSY ++ GAY+E++ G+ YY F+ + + Sbjct: 660 RIMQIIREKRARLEGAIFDSGHRIAMKKVLSYSTNRGAYDEKISGLDYYDFLVNIEK--E 717 Query: 722 LQAEQLSDTLKGICAALFNKRNLTLSVTGTSDIYAEFAAHLAQLDIQDQQVE-PQPKLKA 780 + +SD+LK + +FNK N+ +S +G + Y F + L + + + + Sbjct: 718 DKKSTISDSLKKVRDLIFNKGNMLISYSGKEEEYENFKEKVKYLISKTNNNDFEKEEYNF 777 Query: 781 QNHAGNEGFMSASQVQYVVKGYDFSKLGFVYSGKMQVLKKILSLTYLWNTVRVKGGAYGG 840 + NEG ++ VQYV KG ++ G+ YSG + +L+ IL YLWN VRVKGGAYG Sbjct: 778 ELGKKNEGLLTQGNVQYVAKGGNYKTHGYKYSGALSLLESILGFDYLWNAVRVKGGAYGV 837 Query: 841 NLLLRRDGVLLFTSYRDPNLQETLEVYDQAYRYAESFEADEEEMTQAIIGTLAMFEQPLS 900 RRDG SYRDPN++ TLE YD +Y FEADE EMT+ IIGT+ ++QP+S Sbjct: 838 FSNFRRDGGAYIVSYRDPNIKSTLEAYDNIPKYLNDFEADEREMTKYIIGTIRKYDQPIS 897 Query: 901 PSALRRRADRHYFEQITVEELQQERNEIFSATPEDIRHYARLLKTVTEQNFFSVVGNDSK 960 A +Y T E+LQ+ER EI +A E I+ +A ++K + ++++ V+GN+ K Sbjct: 898 NGIKGDIAVSYYLSNFTYEDLQKEREEIINADVEKIKSFAPMIKDLMKEDYICVLGNEEK 957 Query: 961 MKPAQAIFGSLEELVK 976 +K + +F +++ ++K Sbjct: 958 IKENKDLFNNIKSVIK 973 >ref|NP_348280.1| Zn-dependent metalloprotease, insulinase family [Clostridium acetobutylicum] pir||A97104 Zn-dependent metalloprotease, insulinase family [imported] - Clostridium acetobutylicum gb|AAK79620.1| Zn-dependent metalloprotease, insulinase family [Clostridium acetobutylicum] Length = 976 Score = 723 bits (1866), Expect = 0.0, Method: Compositional matrix adjust. Identities = 380/976 (38%), Positives = 598/976 (61%), Gaps = 10/976 (1%) Query: 4 LKTGQIYSGFQVVHEEYIREIESTVFTMEHQPSGARLLFVQNQDDNKVFSISFRTPPGDS 63 + G IYSGF+ E I EI S +H SGA L+ ++N+DDNKVFSI+F+T P DS Sbjct: 3 FEIGNIYSGFKFESETVIDEINSKGRVFKHIKSGAVLVNLKNKDDNKVFSITFKTLPHDS 62 Query: 64 TGVFHILEHSVLCGSDKYPVKEPFVELLKSSMKTFLNAFTFADKTMYPVASRNHQDFSNL 123 TGV HILEHSVLCGS K+ VKEPF+E+LK S+ T+LNA T+ADKTMYPVASRN +DF NL Sbjct: 63 TGVAHILEHSVLCGSRKFKVKEPFIEILKGSLNTYLNAATYADKTMYPVASRNKKDFMNL 122 Query: 124 MEVYLDSVFKPNIYRQQEIFEQEGWHYDLHHAEDELIYKGVVYNEMKGSYSSPVTVLIDR 183 M+VYLD+VF P+IY EI QEGWHYD+ EDE+ Y GVVYNEMKG+YSSP+++L Sbjct: 123 MDVYLDAVFYPDIYNTPEIIMQEGWHYDIKDEEDEIEYNGVVYNEMKGAYSSPISLLSRS 182 Query: 184 IKKSLYPDTVYRYSSGGDPQDIPALTYEQFLAAHSQYYHPSNSYFYLYGDVNIEERLEFI 243 + + L+ +VY SGG ++I L+YE+ L+ H +YYHPSNS Y+YGD++IEE LEFI Sbjct: 183 MDEELFKGSVYGVDSGGKVENIVDLSYEEALSFHEKYYHPSNSIIYVYGDIDIEEVLEFI 242 Query: 244 HQEYLKSYNRDDFDTAIPLQQP-TGMTELTAEYPILETETAADKTYLSMNYVIGTALDRE 302 + YLK +N+ + D I + + + E EY I E E+ DKTY M++V G ALD E Sbjct: 243 NDNYLKDFNKKNIDADIKVNGAFSKVHEKELEYSISEGESENDKTYFGMSFVTGDALDTE 302 Query: 303 LNLAFAILKNMLMDSNAAPLKRALLESGLGKDVFAFYSDSMIQPLLGITLTHSNPSAKDA 362 L++ +L+++L++++++PL+RA++E +GKDVF + S+++ I L SN KD Sbjct: 303 LSMGLELLESILLEASSSPLRRAIVEENIGKDVFGVFDSSILKNTFSIILKDSNLEDKDK 362 Query: 363 FLDLIRTTLSRLAADGLDEKLVLAAVNSKEFELREADFIQYPKGLTYNIEVMKSWLYDGS 422 F ++++ TL L +G+D+KL+ +N+KEF LRE+DF YP GL YN ++++S LY G Sbjct: 363 FKEVVKNTLKELVKNGIDKKLINGIINAKEFALRESDFDSYPAGLVYNEKILESMLYGGD 422 Query: 423 PATHLEYEAVFASIREQCADRYFERLIETYLLNSDHCSVVILQPSAALAAEKETSIRRQL 482 P +L + V +IR+ YFE LIE Y+LN+++ + ++P L E+E +R +L Sbjct: 423 PFINLRFNDVIKNIRKYAESNYFENLIEKYILNNNYGVFITVKPKKNLEEEREEKLREKL 482 Query: 483 AEYKASLSPEQLGQLVQRTQNLLDRQSRPDAAEDLRKLPKLSLQDINRSVPPQVHTQEYM 542 ++K LS + L +L+ ++L RQ PD+ E+L +P +++ D+ R + T E+ Sbjct: 483 RKFKNGLSKDDLKKLIASNRSLELRQDTPDSEENLESIPLIAIGDVKR----DIETIEHK 538 Query: 543 L---EGIKLIHHEILTNKIAYIKLYWDTGVLAAEQIPYLVLLARALGQLETAAYSIEELT 599 + K+I + T I Y+ +Y++ + IPY LL+ +G++ T Y+ +EL+ Sbjct: 539 IIDENNAKIIWCPLNTRGIQYVSIYFEGKSVPQNMIPYASLLSSVIGKVNTEKYNFKELS 598 Query: 600 GEIGIKTGGIRFQNEVFGANKNSHAGYQPKFSARIKVMEGSISESLTLLHELLYGSNLDN 659 E GG+ F +V+ +N + Y PKF+ R K + + + ++ E++ S D+ Sbjct: 599 NEAMENLGGMDFGLDVYSRPQN-YEDYAPKFAVRAKSLREKLPKMFEIMEEIINHSIYDD 657 Query: 660 FTKLQEIVRREASHMESVLNQKGNEIAASRLLSYFSDMGAYEEQLGGVAYYRFIRELADG 719 + +L+EI+ S ME + G+ +A+ R+ SY S Y + + G+ +Y+FI +++ Sbjct: 658 YKRLKEIIDEIKSRMEMAIRGSGSRMASVRVGSYVSSAYKYLDTITGIDFYKFIVDISSN 717 Query: 720 IDLQAEQLSDTLKGICAALFNKRNLTLSVTGTSDIYAEFAAHLAQLDIQDQQVEPQ-PKL 778 + + E+++ LK +F + NL + + Y F+ ++ + + Sbjct: 718 FEEKKEEVAANLKAASDYIFKRDNLIAAYCAEEEDYETFSKLFNDFTLKLKNNNFKLNDY 777 Query: 779 KAQNHAGNEGFMSASQVQYVVKGYDFSKLGFVYSGKMQVLKKILSLTYLWNTVRVKGGAY 838 K + NE FM +++VQYV KG++F K F ++G + VL+ I + YLWN+VRVKGGAY Sbjct: 778 KFELKKLNEAFMMSTKVQYVAKGFNFRKFNFKHNGALIVLRTIANYDYLWNSVRVKGGAY 837 Query: 839 GGNLLLRRDGVLLFTSYRDPNLQETLEVYDQAYRYAESFEADEEEMTQAIIGTLAMFEQP 898 G ++ L R+G L F SYRDPNL ETL+ Y++ + + F + EM + I+GT++ + P Sbjct: 838 GASMSLSRNGHLAFASYRDPNLLETLKAYEEMVSFVKDFNVNSREMDKYILGTISGIDMP 897 Query: 899 LSPSALRRRADRHYFEQITVEELQQERNEIFSATPEDIRHYARLLKTVTEQNFFSVVGND 958 LS + + Y I E +++ER EI + EDI+ +LK + E+N V G++ Sbjct: 898 LSNYSKCEKVTAQYLTGIDDEYMRKERLEILDCSVEDIKDSYDILKKLNEENCICVFGSE 957 Query: 959 SKMKPAQAIFGSLEEL 974 K+K + +F ++ ++ Sbjct: 958 EKIKENKELFDNVVDI 973 >ref|ZP_00129289.1| COG1026: Predicted Zn-dependent peptidases, insulinase-like [Desulfovibrio desulfuricans G20] Length = 1071 Score = 587 bits (1513), Expect = e-166, Method: Compositional matrix adjust. Identities = 353/955 (36%), Positives = 517/955 (54%), Gaps = 21/955 (2%) Query: 12 GFQVVHEEYIREIESTVFTMEHQPSGARLLFVQNQDDNKVFSISFRTPPGDSTGVFHILE 71 GF +V E I+E+ S H +GA LL + N D+NKVF +SFRTPP DSTGV HILE Sbjct: 111 GFTLVEEREIKELSSRARLWRHDATGAALLSMSNDDENKVFGVSFRTPPHDSTGVAHILE 170 Query: 72 HSVLCGSDKYPVKEPFVELLKSSMKTFLNAFTFADKTMYPVASRNHQDFSNLMEVYLDSV 131 HSVLCGS+KYPVKEPFVELLK S++TFLNAFT+ DKT YPVAS N DF NL++VYLD+ Sbjct: 171 HSVLCGSEKYPVKEPFVELLKGSLQTFLNAFTYPDKTCYPVASTNLADFYNLVDVYLDAA 230 Query: 132 FKPNIYRQQEIFEQEGWHYDLHHAEDELIYKGVVYNEMKGSYSSPVTVLIDRIKKSLYPD 191 F P I EIF+QEGWHY+ + L YKGVV+NEMKG YSSP ++L +R +++L+PD Sbjct: 231 FFPRI--TPEIFQQEGWHYETAQ-DGTLTYKGVVFNEMKGVYSSPESILAERSQQALFPD 287 Query: 192 TVYRYSSGGDPQDIPALTYEQFLAAHSQYYHPSNSYFYLYGDVNIEERLEFIHQEYLKSY 251 Y SGG+P+ IP LTYE F A H YYHP+N+ FY +GD + RL + Q L + Sbjct: 288 ITYGLDSGGNPEHIPDLTYEAFKAFHETYYHPANARFYFWGDDPEDRRLAVLSQ-LLDRF 346 Query: 252 NRDDFDTAIPLQQPTGMTELTAEYPILETETAADKTYLSMNYVIGTALDRELNLAFAILK 311 D + +PLQQ T T E P + + +++N+++ D E N A +L Sbjct: 347 GPLDVQSEVPLQQ-TFDTPKRLEVPYAAGADSDRRGMMTVNWLLPETSDAETNFALQMLD 405 Query: 312 NMLMDSNAAPLKRALLESGLGKDVFAFYSDSMIQPL-LGITLTHSNPSAKDAFLDLIRTT 370 ++L+ A+PL++AL+ESGLG+D+ ++ ++ L L +P+ ++ LI + Sbjct: 406 HILVGLPASPLRKALIESGLGEDLAGGGLENELRQLYFSTGLKGIDPADEEQISSLIFSV 465 Query: 371 LSRLAADGLDEKLVLAAVNSKEFELREADFIQYPKGLTYNIEVMKSWLYDGSPATHLEYE 430 L LA DG+ + AA+N+ EF+LRE + ++P GL + +WLYDG P + L +E Sbjct: 466 LRGLAEDGVPAASIEAAMNTVEFDLRENNTGRFPVGLAVMTRALTTWLYDGDPFSQLAFE 525 Query: 431 AVFASIREQCA--DRYFERLIETYLLNSDHCSVVILQP---SAALAAEKETSIRRQLAEY 485 +IR + A + FE LI +LL++ H + V+L P S AE+E S +LA Sbjct: 526 KPVNAIRARVAVGEPVFENLIRRWLLDNTHRATVVLVPAENSDKARAEREKS---RLAAV 582 Query: 486 KASLSPEQLGQLVQRTQNLLDRQSRPDAAEDLRKLPKLSLQDINRSVPPQVHTQEYMLEG 545 +ASL + L + + L Q PD E L +P+L L D+ +V + QE L+G Sbjct: 583 RASLDEQGLEAVRANAEKLRRMQEEPDTPEALSTIPRLGLHDLA-AVNTPIPAQESPLDG 641 Query: 546 IKLIHHEILTNKIAYIKLYWDTGVLAAEQIPYLVLLARALGQLETAAYSIEELTGEIGIK 605 ++LI H+I I Y+ + + A +P + LL RA+ ++ T+ Y E+ I K Sbjct: 642 MRLITHDIDAKGILYVDAGFSLNRIPAGLVPLVPLLGRAMVEMGTSRYDFVEMGMRIACK 701 Query: 606 TGGIRFQNEVFGANKNSHAGYQPKFSARIKVMEGSISESLTLLHELLYGSNLDNFTKLQE 665 TGGI + V + + + K + + + L+ ++L + LD + + Sbjct: 702 TGGIDADSVVL--TRVDDRTPDARLFVQGKATQANAAALFELMRDVLLDAQLDQKERFRS 759 Query: 666 IVRREASHMESVLNQKGNEIAASRLLSYFSDMGAYEEQLGGVAYYRFIRELADGIDLQAE 725 I+ E + ME L G+ + SRL S+F G EQ+ G+A ++REL +D Sbjct: 760 ILLEEKARMEHRLVPAGHMVVMSRLRSHFGKSGWLGEQMDGLAALEYLRELVRRVDEDWN 819 Query: 726 QLSDTLKGICAALFNKRNLTLSVTGTSDIYAEFAAHLAQL--DIQDQQVEPQPKLKAQNH 783 + L + AL + L++TG+ A H + + + Q P P A Sbjct: 820 GVLADLTAVRQALVGRAGAVLNMTGSGSTLAAAMPHASSFAASLPEGQDVP-PAWFADIR 878 Query: 784 AGNEGFMSASQVQYVVKGYDFSKLGFVYSGKMQVLKKILSLTYLWNTVRVKGGAYGGNLL 843 +E SQV YV K D LG+ Y G V+ K L + +LW+ VRV+GGAYG Sbjct: 879 PVHEALCVPSQVNYVGKAADLYSLGYRYHGSANVIFKHLRMAWLWDKVRVQGGAYGAFCA 938 Query: 844 L-RRDGVLLFTSYRDPNLQETLEVYDQAYRYAESFEADEEEMTQAIIGTLAMFEQPLSPS 902 R GVL SYRDPNL+ TL+VYD++ Y S ++E+ +++G + + + P Sbjct: 939 FDRASGVLAQVSYRDPNLEATLDVYDRSAEYLRSLSLTKDELVTSVVGAIGELDAHMLPH 998 Query: 903 ALRRRADRHYFEQITVEELQQERNEIFSATPEDIRHYARLLKTVTEQNFFSVVGN 957 + T E QQ R+EI S TPED +A +L V+G Sbjct: 999 DRGMASLARTLTGDTEERRQQMRDEILSTTPEDFVRFADVLAEAARTGTVCVLGG 1053 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.318 0.134 0.377 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 1,402,532,340 Number of extensions: 59503492 Number of successful extensions: 156362 Number of sequences better than 1.0e-05: 169 Number of HSP's gapped: 155910 Number of HSP's successfully gapped: 189 Length of query: 976 Length of database: 757,237,578 Length adjustment: 135 Effective length of query: 841 Effective length of database: 390,699,213 Effective search space: 328578038133 Effective search space used: 328578038133 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 131 (55.1 bits)