BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0541.0038.p (399 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|ZP_00179839.1| hypothetical protein Mther228501 [Moorella th... 452 e-126 ref|NP_980629.1| cystathionine beta-lyase [Bacillus cereus ATCC ... 434 e-120 ref|NP_658287.1| Cys_Met_Meta_PP, Cys/Met metabolism PLP-depende... 432 e-120 ref|NP_833967.1| Cystathionine gamma-synthase [Bacillus cereus A... 431 e-119 ref|NP_242493.1| cystathionine gamma-synthase (O-succinylhomoser... 424 e-117 >ref|ZP_00179839.1| hypothetical protein Mther228501 [Moorella thermoacetica ATCC 39073] Length = 378 Score = 452 bits (1164), Expect = e-126, Method: Compositional matrix adjust. Identities = 218/374 (58%), Positives = 279/374 (74%) Query: 5 LRIESRLAQIGSQEDPATGAINYPIYNATAFRHPRLGQSTGFDYIRTKNPTRSVLEEAVA 64 +R+ + L Q+G D TGAI+ PIY + FRHP LGQSTGFDY RT NPTR VLEE +A Sbjct: 1 MRLATELVQLGVGYDSKTGAISTPIYQSATFRHPALGQSTGFDYSRTGNPTRQVLEEGLA 60 Query: 65 ELESGDAAFACSSGMAALTTVFALFGQGDHLVVSLDLYGGTYRLLERILSKYGISASYVD 124 LE G A A +SGMAA+T V LF GDHLVVS DLYGGTYRLL ++ G+ S VD Sbjct: 61 GLEGGCRALAFASGMAAITAVLCLFRPGDHLVVSEDLYGGTYRLLNQVAVPLGLEFSLVD 120 Query: 125 TNDLDGLEASRRPNTKAVFIETPTNPLMMITDIEAVCTWSRRHGLLTIVDNTLLTPFFQR 184 T DL L AS R NTK +F+ETPTNPLM ITDI AV +R+ GLLTIVDNT +TP+ QR Sbjct: 121 TTDLAALAASIRNNTKGIFLETPTNPLMKITDIAAVVALARQRGLLTIVDNTFMTPYLQR 180 Query: 185 PLELGADIIVHSATKYLGGHNDVLAGLIVTKGTELSAEMAILHNSLGAVLAPNDSYQLMK 244 PLELGAD++VHSATKYLGGHNDV+ G + +LS +A + N++GA+ P D + +++ Sbjct: 181 PLELGADLVVHSATKYLGGHNDVVMGAAIAAREDLSERLAFIQNTIGAIPGPQDCWLVIR 240 Query: 245 GMKTLALRMERHESNALALARYLLEHPAIAEVFHPGLPDHPGYDIQKRQSSGNTGIFSFK 304 G+KTLA+R+ER ++NA LAR+L EHP + V++PGLP HPG++I K+QSSG + SF+ Sbjct: 241 GLKTLAVRLERAQANAFELARWLAEHPLVTRVYYPGLPHHPGHEICKKQSSGFGAMLSFE 300 Query: 305 VKDAGYVEPLLRHIRLIAFAESLGGVESLMTYPAVQTHADIPVEIRDAVGVDDRLLRFSV 364 VK AG VE +L+ +++I+FAESLGGVESL+T+P QTHA+IP E+R +G++DRLLR SV Sbjct: 301 VKHAGLVEQILQRLKIISFAESLGGVESLITFPERQTHAEIPAEMRLKLGINDRLLRLSV 360 Query: 365 GIEHADDLIADLGQ 378 G+E +DL ADL Q Sbjct: 361 GLEDLNDLKADLDQ 374 >ref|NP_980629.1| cystathionine beta-lyase [Bacillus cereus ATCC 10987] gb|AAS43237.1| cystathionine beta-lyase [Bacillus cereus ATCC 10987] Length = 370 Score = 434 bits (1115), Expect = e-120, Method: Compositional matrix adjust. Identities = 211/372 (56%), Positives = 270/372 (72%), Gaps = 16/372 (4%) Query: 7 IESRLAQIGSQEDPATGAINYPIYNATAFRHPRLGQSTGFDYIRTKNPTRSVLEEAVAEL 66 IE++LAQIG++ + TG +N P+Y +TA+RH +G+STGFDY RT NPTR +LE+A+A+L Sbjct: 4 IETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAIADL 63 Query: 67 ESGDAAFACSSGMAALTTVFALFGQGDHLVVSLDLYGGTYRLLERILSKYGISASYVDTN 126 E G+ +ACSSGMAA+ V +LF GD L+VS DLYGGTYRL K+ + YV+T Sbjct: 64 ECGEQGYACSSGMAAVLLVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVNTQ 123 Query: 127 DLDGLEASRRPNTKAVFIETPTNPLMMITDIEAVCTWSRRHGLLTIVDNTLLTPFFQRPL 186 + +E + TKA+FIETPTNPLM +TDI AV T ++RHGLL IVDNT TP+ Q+PL Sbjct: 124 SIKQIEQAITTKTKAIFIETPTNPLMQVTDIAAVATVAKRHGLLLIVDNTFYTPYIQQPL 183 Query: 187 ELGADIIVHSATKYLGGHNDVLAGLIVTKGTELSAEMAILHNSLGAVLAPNDSYQLMKGM 246 GADI++HSATKYLGGHNDVL+GL+V KG EL E+A HN+ GAVL+P DS+ L++GM Sbjct: 184 TEGADIVLHSATKYLGGHNDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLIRGM 243 Query: 247 KTLALRMERHESNALALARYLLEHPAIAEVFHPGLPDHPGYDIQKRQSSGNTGIFSFKVK 306 KTLALRM +HE NA A+ YL + + +VF+P G G+ SF++K Sbjct: 244 KTLALRMRQHEENAKAVVAYLNDEDGVTDVFYP----------------GRGGMISFRLK 287 Query: 307 DAGYVEPLLRHIRLIAFAESLGGVESLMTYPAVQTHADIPVEIRDAVGVDDRLLRFSVGI 366 D ++ P L+ + LI FAESLGGVESLMTYPA QTHADIP EIR A GV +RLLRFSVGI Sbjct: 288 DETWINPFLQSLSLITFAESLGGVESLMTYPATQTHADIPEEIRTANGVCNRLLRFSVGI 347 Query: 367 EHADDLIADLGQ 378 E+++DLI DL Q Sbjct: 348 ENSNDLIQDLQQ 359 >ref|NP_658287.1| Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme [Bacillus anthracis A2012] ref|NP_846705.1| cystathionine beta-lyase [Bacillus anthracis str. Ames] gb|AAP28191.1| cystathionine beta-lyase [Bacillus anthracis str. Ames] Length = 370 Score = 432 bits (1112), Expect = e-120, Method: Compositional matrix adjust. Identities = 211/372 (56%), Positives = 270/372 (72%), Gaps = 16/372 (4%) Query: 7 IESRLAQIGSQEDPATGAINYPIYNATAFRHPRLGQSTGFDYIRTKNPTRSVLEEAVAEL 66 IE++LAQIG++ + TG +N P+Y +TA+RH +G+STGFDY RT NPTR +LE+A+A+L Sbjct: 4 IETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAIADL 63 Query: 67 ESGDAAFACSSGMAALTTVFALFGQGDHLVVSLDLYGGTYRLLERILSKYGISASYVDTN 126 E G+ +ACSSGMAA+ V +LF GD L+VS DLYGGTYRL K+ + YV+T Sbjct: 64 EYGEQGYACSSGMAAVLLVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVNTQ 123 Query: 127 DLDGLEASRRPNTKAVFIETPTNPLMMITDIEAVCTWSRRHGLLTIVDNTLLTPFFQRPL 186 + +E + TKA+FIETPTNPLM +TDI AV T ++RHGLL IVDNT TP+ Q+PL Sbjct: 124 SIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATVAKRHGLLLIVDNTFYTPYIQQPL 183 Query: 187 ELGADIIVHSATKYLGGHNDVLAGLIVTKGTELSAEMAILHNSLGAVLAPNDSYQLMKGM 246 GADI++HSATKYLGGHNDVL+GL+V KG EL E+A HN+ GAVL+P DS+ L++GM Sbjct: 184 TEGADIVLHSATKYLGGHNDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLIRGM 243 Query: 247 KTLALRMERHESNALALARYLLEHPAIAEVFHPGLPDHPGYDIQKRQSSGNTGIFSFKVK 306 KTLALRM +HE NA A+ YL + + +VF+P G G+ SF++K Sbjct: 244 KTLALRMRQHEKNAKAVVAYLNDEDGVTDVFYP----------------GRGGMISFRLK 287 Query: 307 DAGYVEPLLRHIRLIAFAESLGGVESLMTYPAVQTHADIPVEIRDAVGVDDRLLRFSVGI 366 D ++ P L+ + LI FAESLGGVESLMTYPA QTHADIP EIR A GV +RLLRFSVGI Sbjct: 288 DETWINPFLQSLSLITFAESLGGVESLMTYPATQTHADIPEEIRTANGVCNRLLRFSVGI 347 Query: 367 EHADDLIADLGQ 378 E+++DLI DL Q Sbjct: 348 ENSNDLIQDLQQ 359 >ref|NP_833967.1| Cystathionine gamma-synthase [Bacillus cereus ATCC 14579] gb|AAP11168.1| Cystathionine gamma-synthase [Bacillus cereus ATCC 14579] Length = 370 Score = 431 bits (1108), Expect = e-119, Method: Compositional matrix adjust. Identities = 210/372 (56%), Positives = 270/372 (72%), Gaps = 16/372 (4%) Query: 7 IESRLAQIGSQEDPATGAINYPIYNATAFRHPRLGQSTGFDYIRTKNPTRSVLEEAVAEL 66 IE++LAQIG++ + TG +N P+Y +TA+RH +G+STGFDY RT NPTR +LE+A+A+L Sbjct: 4 IETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAIADL 63 Query: 67 ESGDAAFACSSGMAALTTVFALFGQGDHLVVSLDLYGGTYRLLERILSKYGISASYVDTN 126 E G+ +ACSSGMAA+ V +LF GD L+VS DLYGGTYRL K+ + YV+T Sbjct: 64 EYGEQGYACSSGMAAVLLVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVNTQ 123 Query: 127 DLDGLEASRRPNTKAVFIETPTNPLMMITDIEAVCTWSRRHGLLTIVDNTLLTPFFQRPL 186 + +E + TKA+FIETPTNPLM +TDI AV T ++R+GLL IVDNT TP+ Q+PL Sbjct: 124 SIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATVAKRNGLLLIVDNTFYTPYIQQPL 183 Query: 187 ELGADIIVHSATKYLGGHNDVLAGLIVTKGTELSAEMAILHNSLGAVLAPNDSYQLMKGM 246 GADI++HSATKYLGGHNDVL+GL+V KG EL E+A HN+ GAVL+P DS+ L++GM Sbjct: 184 TEGADIVLHSATKYLGGHNDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLIRGM 243 Query: 247 KTLALRMERHESNALALARYLLEHPAIAEVFHPGLPDHPGYDIQKRQSSGNTGIFSFKVK 306 KTLALRM +HE NA A+ YL + + +VF+P G G+ SF++K Sbjct: 244 KTLALRMRQHEENAKAVVAYLNDEDGVTDVFYP----------------GRGGMISFRLK 287 Query: 307 DAGYVEPLLRHIRLIAFAESLGGVESLMTYPAVQTHADIPVEIRDAVGVDDRLLRFSVGI 366 D ++ P L+ + LI FAESLGGVESLMTYPA QTHADIP EIR A GV +RLLRFSVGI Sbjct: 288 DEAWINPFLQSLSLITFAESLGGVESLMTYPATQTHADIPEEIRTANGVCNRLLRFSVGI 347 Query: 367 EHADDLIADLGQ 378 E+++DLI DL Q Sbjct: 348 ENSNDLIQDLKQ 359 >ref|NP_242493.1| cystathionine gamma-synthase (O-succinylhomoserine (thiol)-lyase) [Bacillus halodurans] pir||C83853 cystathionine gamma-synthase (O-succinylhomoserine (thiol)-lyase) metB [imported] - Bacillus halodurans (strain C-125) dbj|BAB05346.1| cystathionine gamma-synthase (O-succinylhomoserine (thiol)-lyase) [Bacillus halodurans] Length = 378 Score = 424 bits (1091), Expect = e-117, Method: Compositional matrix adjust. Identities = 208/378 (55%), Positives = 267/378 (70%), Gaps = 17/378 (4%) Query: 1 MDEKLRIESRLAQIGSQEDPATGAINYPIYNATAFRHPRLGQSTGFDYIRTKNPTRSVLE 60 M+ K +E+ L QIG++ D TGAIN P+Y +TA+RH +G+STG+DY RT NPTR VLE Sbjct: 1 MNRK-ELETALVQIGNRMDDRTGAINTPVYFSTAYRHSGIGESTGYDYARTGNPTREVLE 59 Query: 61 EAVAELESGDAAFACSSGMAALTTVFALFGQGDHLVVSLDLYGGTYRLLERILSKYGISA 120 +A+A LE+GD FACSSGMAA+ TVF+LF GD ++ S DLYGGTYRL E K+G+S Sbjct: 60 KAIATLENGDQGFACSSGMAAIQTVFSLFQSGDEIIASQDLYGGTYRLFEGGWKKWGLSF 119 Query: 121 SYVDTNDLDGLEASRRPNTKAVFIETPTNPLMMITDIEAVCTWSRRHGLLTIVDNTLLTP 180 SY D +L LE T+A+FIETPTNPLM +I + + +HGLL IVDNT TP Sbjct: 120 SYADPRNLAALEQQITEKTRALFIETPTNPLMQEANIRELAALANKHGLLLIVDNTFYTP 179 Query: 181 FFQRPLELGADIIVHSATKYLGGHNDVLAGLIVTKGTELSAEMAILHNSLGAVLAPNDSY 240 Q+PL G I++HSA+KYLGGHNDV+AGLIV KG EL ++A HN +G L+ DS+ Sbjct: 180 LLQQPLNEGTHIVIHSASKYLGGHNDVIAGLIVAKGQELCEQIAYYHNGIGGTLSAFDSW 239 Query: 241 QLMKGMKTLALRMERHESNALALARYLLEHPAIAEVFHPGLPDHPGYDIQKRQSSGNTGI 300 L++GMKTLALRME+H++NA A+A YL +H + +V +P G G+ Sbjct: 240 LLIRGMKTLALRMEQHQNNARAIASYLEKHEGVTDVLYP----------------GRGGM 283 Query: 301 FSFKVKDAGYVEPLLRHIRLIAFAESLGGVESLMTYPAVQTHADIPVEIRDAVGVDDRLL 360 SF+++ +V P L+ ++LI+FAESLGGVESLMTYPA QTHADIP ++R A GV +RLL Sbjct: 284 LSFRIQSESWVNPFLQSLKLISFAESLGGVESLMTYPATQTHADIPEDVRIANGVCNRLL 343 Query: 361 RFSVGIEHADDLIADLGQ 378 RFSVGIEH DLIADL Q Sbjct: 344 RFSVGIEHVGDLIADLDQ 361 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.319 0.136 0.392 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 550,760,176 Number of extensions: 22280545 Number of successful extensions: 56840 Number of sequences better than 1.0e-05: 1843 Number of HSP's gapped: 53369 Number of HSP's successfully gapped: 2147 Length of query: 399 Length of database: 757,237,578 Length adjustment: 128 Effective length of query: 271 Effective length of database: 409,704,906 Effective search space: 111030029526 Effective search space used: 111030029526 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 127 (53.5 bits)