BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0489.0026.p (1557 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gb|AAR87760.1| putative peptide synthetase/polyketide synthase [... 503 e-140 ref|ZP_00110274.1| COG3321: Polyketide synthase modules and rela... 502 e-140 ref|ZP_00110270.1| COG3321: Polyketide synthase modules and rela... 502 e-140 ref|ZP_00074380.1| COG3321: Polyketide synthase modules and rela... 494 e-137 ref|ZP_00106167.1| COG3321: Polyketide synthase modules and rela... 491 e-137 >gb|AAR87760.1| putative peptide synthetase/polyketide synthase [Bacillus cereus] Length = 2562 Score = 503 bits (1295), Expect = e-140, Method: Compositional matrix adjust. Identities = 269/643 (41%), Positives = 373/643 (58%), Gaps = 22/643 (3%) Query: 2 EIAVIGLAGRFPGAGTISEYWDNLKNGVHSVQTFSEQELIAAGVEPGLAAKAEYVKAKGY 61 ++AV+G+A R PGA + ++W NL+ G+ S++TF+++EL G+ + K Y+K+KGY Sbjct: 1038 DVAVVGMAVRMPGASNLKQFWSNLEQGIESIRTFTDEELSEMGIPKEVIQKPNYIKSKGY 1097 Query: 62 LEAGHCFDARFFDYTPLEAELMDPQMKVFHECIWXXXXXXXXXXXXXQQLIGLFAGASPN 121 LE FD FFDY+ EAE+MDPQ+++ HEC W G++ G SPN Sbjct: 1098 LEDVDAFDNEFFDYSLKEAEMMDPQLRILHECAWEALEQAGEVNSSHMN-TGVYVGGSPN 1156 Query: 122 HVWEGLMGLSGKSGVMGHWAASQLLDKDYLSLRIAHKLNLKGPALSIYTACSTSLVAVHM 181 W + S S + + A L +KD+ + R+A+KLNLKGPA+++ TACSTSLVA+ Sbjct: 1157 FHWLRSIA-SESSNTLEDFQAMLLNEKDFFATRLAYKLNLKGPAITVQTACSTSLVAIQN 1215 Query: 182 AAQSLLNGECDIALAGGVTVTLPEKSGYEYQEGMILSPDGKCRAFXXXXXXXXXXXXXXX 241 A L++G CDIALAGGV++T P K+GY Y++GMI SPDG CRAF Sbjct: 1216 AWADLIDGRCDIALAGGVSITYPTKTGYLYEDGMIFSPDGHCRAFDKDAQGTVGGNGAGI 1275 Query: 242 XVLKRLQDALDDGDQIYAVIKGSAVNNDGLQKTGFTAPSTIGQAEVIRTALKLAEVSPDS 301 VLKRL+DAL DG+ I+ VIKG+AVNNDG K GFTAP GQA VI++A ++A V P+ Sbjct: 1276 VVLKRLEDALRDGNLIHGVIKGAAVNNDGSNKAGFTAPGVDGQAAVIKSAHEIAGVKPEE 1335 Query: 302 IDYIECHGTGTPLGDPIELEALELGYNPERRHACALGSVKTNIGHLDSAAGIASFIKTVL 361 I YIE HGTGT LGDPIE+EAL+L + + +GSVKTNIGHLD+AAG+ FIKTVL Sbjct: 1336 ISYIETHGTGTQLGDPIEVEALKLAFGKQEPGRVLIGSVKTNIGHLDAAAGVGGFIKTVL 1395 Query: 362 ALKHNILPPSLHFQTPNPVLKVIEKGFYINDRLTEWPSKNEPLRAGISAFGIGGTNAHII 421 ALK+ +PPSLH+ PNP + + F +N L W K E RAG+S+FG+GGTNAHI+ Sbjct: 1396 ALKNKKIPPSLHYNNPNPSIDFGKNPFRVNTELIPW--KEEVRRAGVSSFGMGGTNAHIV 1453 Query: 422 VEQAPPPREASAGREWQLLPVSAKTPSALAEIKQDLERYSKTEPR-RLEDIAYTLQVGRK 480 +E P + + W LL VSAKT +L + DL Y K P L D AYTLQ GR+ Sbjct: 1454 LESVPDNAKNFEKQSWNLLTVSAKTEESLDKATNDLLLYLKENPEISLSDTAYTLQKGRR 1513 Query: 481 HFPIRELALVNRKSQRVLQFAETATMKGTAGLENAPVIFVIPDFTQRXXXXXXXXXXXXX 540 FP R + N + + +T ++ T +E+ P+ F+ Sbjct: 1514 EFPYRTAVVANGIEDAIEKLVDTG-LEKTNAMESRPLAFLFS-----GQGSQYINMGRDL 1567 Query: 541 XXXXPGARRFLNQVLG---------MMNRLVP--DGAAVKLEDLRKREYHPVLAFGSYYA 589 P R ++Q L M N L P + E L + L F YA Sbjct: 1568 YENEPVFREHVDQGLALLSNWLDIDMKNILYPTKETEDKATEQLNRTSMTQPLLFTIEYA 1627 Query: 590 VGKLFIEWGLHPEAVIGRGKSQWLAACLSGELSLEEAVRSFLL 632 + KL + WG++P + G +++AACL+ +S E+A+ ++ Sbjct: 1628 LAKLLMNWGVYPRVMFGHSIGEFVAACLAEVMSYEDALHLVMI 1670 Score = 313 bits (802), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 219/721 (30%), Positives = 350/721 (48%), Gaps = 40/721 (5%) Query: 654 IWLVLGAGNEAQPFLDKQ--SSKPQII------ALEKLNTYS-LMAAVGTMWLYGQDIKW 704 I L +G GN F+ K SK Q+ L+K N L +G +W+ G I W Sbjct: 1816 ICLEIGPGNALSTFVLKHLNRSKDQLALNMLRHPLDKSNDLEHLCKQIGRLWMQGGTIDW 1875 Query: 705 RELYQHEQRNRLSLPTYAFDRQEFPVDPELFNLNHLLNRPPSGKGGTPADRDDIRKWFYI 764 E + L LPTY F ++ F DP + L + G + +I+ WFY+ Sbjct: 1876 NTFNNSENKRLLDLPTYPFMKKRFKADPFFNTQSQSLTQETRGHN----KQANIKDWFYL 1931 Query: 765 PAWESAALPNYEGRMLSRDAAWFIFCDPGGLGEALGDLLRQQQIRCIMVEHAEHYQQITA 824 P+WE L + + + + W IF D L + L+++ I V+ + + + Sbjct: 1932 PSWERKTLKSIQIKK-EQKYKWLIFNDHLNRFNRLIEKLKREGHDVIEVKTGGIFSEKSD 1990 Query: 825 DHYRVNPLRSEEMDRLYHSL---DAVPDHICYLWTVTSPMEPEL--ANIETGQQLFLHHI 879 Y + P + + L+ L D +P+ I + W+ E L IE + + Sbjct: 1991 GLYTICPSQKMHYEMLFSELEQKDLLPNKIIHAWSFNPVNEVILDQERIERSMNEGYYSL 2050 Query: 880 LRLVQFLGTAAAAQEVHLQIVSNGLYSITQEEM-LCPMKGLLLGASKIIPYEYPNIKVCH 938 L + Q +G + L I ++ ++ +T E+ L P + +LG SKI E+ NIK Sbjct: 2051 LYIAQAIGKINYEGALQLNIFTDRMFEVTGTELNLKPEQATILGFSKICNLEFQNIKCRT 2110 Query: 939 VDFPLAEGDPARQREQARQMLREFQFEFPNKQVAYRGKSRWIEAVQKPLLLASPGKVSLF 998 +D + D + E+A M E + + VAYRG+ RW + + + ++ Sbjct: 2111 IDM---DTDSQQMFEEAGLM--ESFVDSTDIVVAYRGRHRWAQTIIQSPFEEEDVEIDRL 2165 Query: 999 RNNLVCMITXXXXXXXXXXXXXXXTQY-TARLVLVGRSAFPPKSEWDQWMNRPDDAEVAR 1057 R + V +IT + +L+L+GRS FPP+++W+Q++ D+ V+R Sbjct: 2166 RESGVYLITGGLGGIGFEIAKDLANRVPNVKLILIGRSEFPPRNQWEQYLENKDE-RVSR 2224 Query: 1058 IIRTIRALEAAGAVIEVHSADISDFSAMQQVVARAEARLGPITGVLHTAGVADYAGVIQR 1117 +I + +E+ GA + SAD+S+ M+Q + +A++R G I GV+H AGVADY G++ Sbjct: 2225 VISDLLTMESQGAEYMILSADVSNQDDMKQAIEKAKSRFGSINGVIHAAGVADYLGIMMN 2284 Query: 1118 RTQAMTDEVLLPKVKGTLVLDTLFRNRRLDFFVLFSSIGNYIYGRKFGQVGYNAANEFLD 1177 R + +++L PK+KGTLVLD L ++ +DFFVL SSIGN Y KFGQ GYNAANEFLD Sbjct: 2285 REKESNNKILAPKIKGTLVLDALLKDEPIDFFVLCSSIGNVAYHMKFGQSGYNAANEFLD 2344 Query: 1178 AFVHYRLQNREGFTATINWNDWAEAGMSVKAMEK-----NRSLHKAVNDLQFEAEAITTE 1232 AF Y+ + FT I W DW E GMS+K+ E N + ++D +T E Sbjct: 2345 AFAFYKRAHDGVFTVAITWPDWQEVGMSLKSAEIWAKQFNMDMESVLHD------GVTVE 2398 Query: 1233 QGVNVFRYIMENQMNRVIVSALDLPALMEESNNISVEVILEQXXXXXXXXXXXXXXGSSS 1292 +G+ VFR I+ +V+VS +DL + N E +LE+ + Sbjct: 2399 EGLKVFRSIINRNQQQVVVSPIDLHWKLLNGANYYNE-LLEKGSKNRLKQNRSDVSTTYR 2457 Query: 1293 LLTEAGLQQQIADIWSTVLGIEAIGIDEDFFALGGDSLKAITIVSLVFKKLGVKLPLPAF 1352 T ++QQ+ ++ + GIE IGI ++FF LG SL + I + + LP+ Sbjct: 2458 PPTNE-IEQQLYELLKDMFGIEEIGIYDNFFDLGMSSLDLVRINVKLKEAFKRDLPIVVL 2516 Query: 1353 F 1353 + Sbjct: 2517 Y 2517 Score = 60.8 bits (146), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 77/158 (48%), Gaps = 9/158 (5%) Query: 1374 ARIKRAPQKEGYPLTPGQKRLYFLSQMEQENKQYNNIIALQVNGPLDFGKLEACLKQLIR 1433 +I + ++ LTP Q+ + + E E K Y+ + L + G ++ K E + R Sbjct: 5 VKIHKEDIEDVIALTPVQEGILYHYLKEPEGKLYHEELRLCLTGKINIPKFEEAWNYVTR 64 Query: 1434 RHESLRTCFRRIGGEWVQWIEEEVQLALDVVDIKGTVNDKHIEAWIQAFDLAAAPL-WKI 1492 +E LRT FR W + +++ VQL L +D + ++FDL P ++ Sbjct: 65 ENEMLRTIFR-----W-EKVKQPVQLILKEHTPNIIYSDGKVSNDTESFDLQTVPFSIEL 118 Query: 1493 GVFKEGEHRHLIVFNIHHIITDGTSNAILIDEFTTLYQ 1530 EGE+ +V HHI+ DG SN+I++ EF +Y+ Sbjct: 119 CHLNEGEYE--MVLRHHHILFDGWSNSIILQEFIKVYR 154 >ref|ZP_00110274.1| COG3321: Polyketide synthase modules and related proteins [Nostoc punctiforme] Length = 1626 Score = 502 bits (1293), Expect = e-140, Method: Compositional matrix adjust. Identities = 281/645 (43%), Positives = 387/645 (60%), Gaps = 24/645 (3%) Query: 2 EIAVIGLAGRFPGAGTISEYWDNLKNGVHSVQTFSEQELIAAGVEPGLAAKAEYVKAKGY 61 EIA++G+ GRFP A I ++W NL++GV S+ FS++EL+++ ++P ++ +YVKA Sbjct: 13 EIAIVGMNGRFPRAKNIEQFWQNLRDGVESISFFSDEELLSSRIDPATLSQPQYVKAGSV 72 Query: 62 LEAGHCFDARFFDYTPLEAELMDPQMKVFHECIWXXXXXXXXXXXXXQQLIGLFAGASPN 121 LE FDA FFD++ EA++ DPQ ++F EC W IG++AGAS N Sbjct: 73 LEDIELFDASFFDFSAKEAQITDPQHRLFLECAWEALESAGYNSEIYAGRIGVYAGASLN 132 Query: 122 HVWEGLMGLSGKSGVM---GHWAASQLLDKDYLSLRIAHKLNLKGPALSIYTACSTSLVA 178 + L L + ++ G + S ++L +++KLNLKGP+L++ TACSTSLVA Sbjct: 133 TYF--LTNLYTQPKIIESVGSYRISIGNSPNFLPTYVSYKLNLKGPSLNVQTACSTSLVA 190 Query: 179 VHMAAQSLLNGECDIALAGGVTVTLPEKSGYEYQEGMILSPDGKCRAFXXXXXXXXXXXX 238 VH+A QSLLNGE DIALAGGV++ +P K+GY YQ+G I+SPDG CRAF Sbjct: 191 VHLACQSLLNGESDIALAGGVSIQVPHKTGYRYQQGGIMSPDGHCRAFDAKAQGIISGNG 250 Query: 239 XXXXVLKRLQDALDDGDQIYAVIKGSAVNNDGLQKTGFTAPSTIGQAEVIRTALKLAEVS 298 VLKRL+DAL DGD I+AVIKGSA+NNDG K GFTAPS GQA+VI AL +A V Sbjct: 251 VGIVVLKRLEDALADGDCIHAVIKGSAINNDGSLKVGFTAPSVDGQAKVIAEALAMARVE 310 Query: 299 PDSIDYIECHGTGTPLGDPIELEALELGYNP-ERRHACALGSVKTNIGHLDSAAGIASFI 357 ++I Y+E HGTGT LGDPIE+ +L + P ++++ CA+ SVKTNIGHLD+AAG+A I Sbjct: 311 SETISYVETHGTGTVLGDPIEIASLTQAFRPTDKKNFCAIASVKTNIGHLDAAAGVAGLI 370 Query: 358 KTVLALKHNILPPSLHFQTPNPVLKVIEKGFYINDRLTEWPSKNEPLRAGISAFGIGGTN 417 KTVLALKH +PPSLHF+ PNP + FY+ND+L+EW S P RAG+S+FGIGGTN Sbjct: 371 KTVLALKHQQIPPSLHFEQPNPQIDFANSPFYVNDKLSEWKSNGTPRRAGVSSFGIGGTN 430 Query: 418 AHIIVEQAP---PPREASAGREWQLLPVSAKTPSALAEIKQDLERYSKTEPR-RLEDIAY 473 AH+I+E+AP R+ GR++ LL +SAKT SAL +L + K L DIAY Sbjct: 431 AHVILEEAPVWEQGRQRRQGRKYHLLVISAKTKSALETATANLANHLKQHLELNLADIAY 490 Query: 474 TLQVGRKHFPIRELALVNRKSQRVLQFAETATMKGTAGLENAP----VIFVIP-DFTQ-- 526 TL VGR+ F R + LV + + ET + P + F+ P TQ Sbjct: 491 TLGVGRRGFSDRRI-LVCQNLNDAVTVLETPVSERVFTKFTEPSGQQIAFMFPGQGTQYV 549 Query: 527 ---RXXXXXXXXXXXXXXXXXPGARRFLNQVLGMMNRLVPDGAAVKL-EDLRKREYHPVL 582 R + +L L + L P L + L++ Sbjct: 550 NMGRELYETEIIFRKQVDYCCEFLKSYLK--LDLRTLLYPHQQTEALTQQLQQTHITQSA 607 Query: 583 AFGSYYAVGKLFIEWGLHPEAVIGRGKSQWLAACLSGELSLEEAV 627 F YA+ +L++ WG+ P A+IG +++AAC++G SLEEA+ Sbjct: 608 VFVVEYALAQLWMAWGVRPNAMIGHSIGEYVAACIAGVFSLEEAL 652 Score = 58.2 bits (139), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 24/68 (35%), Positives = 43/68 (63%) Query: 1289 GSSSLLTEAGLQQQIADIWSTVLGIEAIGIDEDFFALGGDSLKAITIVSLVFKKLGVKLP 1348 G++ + +++ IADIW + G + + I ++FF LGGDSL A+ +SL+ KKL + +P Sbjct: 1523 GNTYAASRKKIEKTIADIWQELFGFDNVNIHDNFFELGGDSLTALQAISLLNKKLDLDIP 1582 Query: 1349 LPAFFHKP 1356 + + + P Sbjct: 1583 IESIYEAP 1590 Score = 57.4 bits (137), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 29/96 (30%), Positives = 52/96 (54%), Gaps = 7/96 (7%) Query: 652 EEIWLVLGAGNEAQPFLDKQSSKPQIIAL-------EKLNTYSLMAAVGTMWLYGQDIKW 704 + I L +G G +KQ + Q+I ++ + L+ +G +WL G ++ W Sbjct: 801 KRILLEVGPGRTLSTLANKQKAAQQVILSSLRHPQNQQSDVAFLLNTLGRLWLEGINVDW 860 Query: 705 RELYQHEQRNRLSLPTYAFDRQEFPVDPELFNLNHL 740 E Y E+R+R+ LPTY F+R+ + ++P L N ++L Sbjct: 861 SEFYADEERHRIPLPTYPFERKRYWIEPILANDDNL 896 >ref|ZP_00110270.1| COG3321: Polyketide synthase modules and related proteins [Nostoc punctiforme] Length = 1959 Score = 502 bits (1292), Expect = e-140, Method: Compositional matrix adjust. Identities = 297/694 (42%), Positives = 404/694 (58%), Gaps = 36/694 (5%) Query: 2 EIAVIGLAGRFPGAGTISEYWDNLKNGVHSVQTFSEQELIAAGVEPGLAAKAEYVKAKGY 61 EIA+IG+AG+FPGA E+W NL+ GV S+ F+++EL+A+G++ ++VKA+ Sbjct: 14 EIAIIGIAGKFPGAKNTDEFWQNLQRGVESISVFTDEELLASGIDAATLKNPKFVKARAV 73 Query: 62 LEAGHCFDARFFDYTPLEAELMDPQMKVFHECIWXXXXXXXXXXXXXQQLIGLFAGASPN 121 LE FDA FF + P EA++ DPQ ++F EC + Q IG++AGAS Sbjct: 74 LEDVELFDASFFGFNPREADITDPQHRLFLECAYIALEDAGYDSENYQGSIGVYAGAS-- 131 Query: 122 HVWEG-LMGLSGKSGVMGHWAASQLL---DKDYLSLRIAHKLNLKGPALSIYTACSTSLV 177 + G L+ + ++ QL DKDYL+ R+++KLNL+GP+ ++ TACSTSLV Sbjct: 132 --FSGYLLNVYLNEDIIKSIDYHQLAIAGDKDYLTTRVSYKLNLEGPSYTVQTACSTSLV 189 Query: 178 AVHMAAQSLLNGECDIALAGGVTVTLPEKSGYEYQEGMILSPDGKCRAFXXXXXXXXXXX 237 AVH+AAQSLLNGECD+ALAGGV++ K+GY Y+EG I SPDG CRAF Sbjct: 190 AVHLAAQSLLNGECDMALAGGVSINSSGKTGYLYKEGGIGSPDGHCRAFDAQAQGTVGGE 249 Query: 238 XXXXXVLKRLQDALDDGDQIYAVIKGSAVNNDGLQKTGFTAPSTIGQAEVIRTALKLAEV 297 VLKRL DAL DGD I+A+IKGSAVNNDG K +TAP GQA+VIRTA +AEV Sbjct: 250 GVGIVVLKRLDDALADGDTIHAIIKGSAVNNDGSFKVSYTAPRIDGQAKVIRTAQVVAEV 309 Query: 298 SPDSIDYIECHGTGTPLGDPIELEALELGY--NPERRHACALGSVKTNIGHLDSAAGIAS 355 P++I YIE HGTGT LGDPIE+ AL + E++ CA+GSVKTNIGHLD+AAG+ Sbjct: 310 EPETITYIEAHGTGTSLGDPIEIAALTQAFRATTEKKGFCAIGSVKTNIGHLDAAAGVTG 369 Query: 356 FIKTVLALKHNILPPSLHFQTPNPVLKVIEKGFYINDRLTEWPSKNEPLRAGISAFGIGG 415 IKTVLALKH +PPSLHFQ PNP + FY+N LTEW + P RAG+S+FGIGG Sbjct: 370 LIKTVLALKHQQIPPSLHFQQPNPQIDFANSPFYVNTTLTEWTTNGIPRRAGVSSFGIGG 429 Query: 416 TNAHIIVEQAPPPREAS-----AGREWQLLPVSAKTPSALAEIKQDLERYSKTEPR-RLE 469 TNAH+I+E+AP + S GR++ LL +SAKT SAL +L + K P L Sbjct: 430 TNAHVILEEAPAKEQGSRGAGEQGRKYHLLVLSAKTESALETATANLANHLKQHPNLNLA 489 Query: 470 DIAYTLQVGRKHFPIRELALVNRKSQRVLQFAETATMKGTAGLE---NAPVIFVIP-DFT 525 D+A+TL +GR+ F R + + + V + + + + + + PV+F+ T Sbjct: 490 DVAHTLGIGRRAFDHRRIVVCQDMNDAVKVLSTSDSQRVFTHYQQPCHRPVVFMFSGQGT 549 Query: 526 QRXXXXXXXXXXX-XXXXXXPGARRFLNQVLGMMNR--LVPD---GAAVKLEDLRKREYH 579 Q L LG R L PD A LE + Sbjct: 550 QYVNMARELYGSEPIFTLTVDSCCELLQPHLGFDLRHVLYPDEAQNAKATLELQQTSVAQ 609 Query: 580 PVLAFGSYYAVGKLFIEWGLHPEAVIGRGKSQWLAACLSGELSLEEAVRSFLLSLDECGM 639 P L F YA+ +L++ WG+ PEA+IG +++AA L+G SLE+A+ L+++ + Sbjct: 610 PAL-FVIEYALAQLWMAWGVQPEAMIGHSIGEYVAATLAGVFSLEDAL--MLVAIRGRLI 666 Query: 640 ERPEAGRRSSRREEIWLVLGAGNEAQPFLDKQSS 673 ++ G E+ V E QP LD Q S Sbjct: 667 QQLPTG-------EMLSVQLPEQEVQPLLDSQLS 693 Score = 285 bits (728), Expect = 8e-75, Method: Compositional matrix adjust. Identities = 193/622 (31%), Positives = 315/622 (50%), Gaps = 29/622 (4%) Query: 753 ADRDDIRKWFYIPAWESAALPN--YEGRMLSRDAAWFIFCDPGGLGEALGDLLRQQQIRC 810 + + DI WFYIP+W+ P G +++ W +F D GLGE L L + Sbjct: 1304 SKKPDIADWFYIPSWKRTMPPQPFQPGFGITQPGCWLVFVDEFGLGERLVKQLVLENQDV 1363 Query: 811 IMVEHAEHYQQ---ITADHYRVNPLRSEEMDRLY---HSLDAVPDHICYLWTVTSPMEPE 864 I V+ E +QQ + Y +NP + ++ + L +L +P I +LW+VTS Sbjct: 1364 ITVKVGEQFQQSSEYSQYTYTINPEKEDDYNTLLKGLRTLGKIPRRIVHLWSVTSNSYTN 1423 Query: 865 LANIETG--QQLFLHHILRLVQFLGTAAAAQE---VHLQIVSNGLYSITQEEMLCPMKGL 919 A G LFL + + L A + V + IVSN L +T EMLCP K L Sbjct: 1424 SAIEALGWSSLLFLGQAMSDDKALRVYAENNQTDAVEIAIVSNNLQEVTGSEMLCPEKAL 1483 Query: 920 LLGASKIIPYEYPNIKVCHVDFPLAEGDPARQREQARQMLREFQFEFPNKQVAYRGKSRW 979 +LGA K++P EY NI +D + E + + + + ++ E ++ +AYRG++RW Sbjct: 1484 VLGACKVMPLEYANINCRSIDVVIPESESGEE-QLIKALIAELTTYTSDQVIAYRGRNRW 1542 Query: 980 IEAVQKPLLLASPGKVSLFRNNLVCMITXXXXXXXXXXXXXXXTQYTARLVLVGRSAFPP 1039 ++ + P+ L +L R V +IT A+L+L+GRSAFP Sbjct: 1543 VQDFE-PVQLHGTVAGNLLREQGVYLITGGLGGVGLLLAEYLAQTVQAKLILLGRSAFPD 1601 Query: 1040 KSEWDQWMNRPDDAE-VARIIRTIRALEAAGAVIEVHSADISDFSAMQQVVARAEARLGP 1098 + +W +W++ D + +++ I+ ++A++ GA + V S D+++ M V+ +A R G Sbjct: 1602 QDKWSEWLSTHDRHDSISQKIQKLQAMKTLGAEVMVVSTDVTNLEQMSAVLKKANQRFGE 1661 Query: 1099 ITGVLHTAGVADYAGVIQRRTQAMTDEVLLPKVKGTLVLDTLFRNRRLDFFVLFSSIGNY 1158 I GV+H A V G++Q T+ + PKV+GT VL+TLF+ +LDFFVL SS+ ++ Sbjct: 1662 IHGVIHAAAVYG-GGMMQLATKETVASAIAPKVQGTRVLETLFQESKLDFFVLCSSLSSF 1720 Query: 1159 IYGRKFGQVGYNAANEFLDAFVHYRLQNREG--FTATINWNDWAEAGMSVKAMEKNRSLH 1216 G V Y AAN FLD+F Y F +INW+ W GM+V + H Sbjct: 1721 --AGTSGMVDYTAANAFLDSFAQYSAAKYGTWKFIKSINWDRWNNVGMAVPVEAR----H 1774 Query: 1217 KAVNDLQFEAEAITTEQGVNVFRYIM-ENQMNRVIVSALDLPALMEESNNI-SVEVILEQ 1274 + + + A +T +G+ F+ I+ + + +VI+S D +L++ ++ S+E L Q Sbjct: 1775 QQITGKELIA-GMTAFEGIEAFKRILCSSTVPQVIISTQDFLSLIKPKESVESLEEKLAQ 1833 Query: 1275 XXXXXXXXXXXXXXGSSSLLTEAGLQQQIADIWSTVLGIEAIGIDEDFFALGGDSLKAIT 1334 ++ + +++ +ADIW +LGIE +GI ++FF LGGDSL A Sbjct: 1834 LSQYKSTHPRPNL-ANTYVAPNNEIERNLADIWQQILGIEKVGIHDNFFELGGDSLFATQ 1892 Query: 1335 IVSLVFKKLGVKLPLPAFFHKP 1356 +VS + K ++L FF+ P Sbjct: 1893 LVSQLCKVFQIELSYKGFFNGP 1914 >ref|ZP_00074380.1| COG3321: Polyketide synthase modules and related proteins [Trichodesmium erythraeum IMS101] Length = 1909 Score = 494 bits (1271), Expect = e-137, Method: Compositional matrix adjust. Identities = 276/652 (42%), Positives = 391/652 (59%), Gaps = 33/652 (5%) Query: 2 EIAVIGLAGRFPGAGTISEYWDNLKNGVHSVQTFSEQELIAAGVEPGLAAKAEYVKAKGY 61 EIA+IG++GRFPGA + ++WDNLKNGV S+ S+++L +GV P + YVK Sbjct: 14 EIAIIGMSGRFPGAKNVEDFWDNLKNGVESISLLSDKQLSKSGVAPEILNNPNYVKVNSM 73 Query: 62 LEAGHCFDARFFDYTPLEAELMDPQMKVFHECIWXXXXXXXXXXXXXQQLIGLFAGAS-P 120 + FDA FF+Y+P EAE +DPQ ++F EC W + IG++AG P Sbjct: 74 VSDIDMFDANFFNYSPREAEEIDPQQRLFLECAWEAIESSGYNPENYEGSIGVYAGGGLP 133 Query: 121 NHVWEGLMGLSGKSGVM-GHWAASQLL--DKDYLSLRIAHKLNLKGPALSIYTACSTSLV 177 ++ + L + ++ G+ +Q++ DKDYL+ R A+KLNL GPAL+I TACSTSLV Sbjct: 134 TYL---MYNLEDQDFILLGNRYFTQMVGNDKDYLATRTAYKLNLTGPALNIQTACSTSLV 190 Query: 178 AVHMAAQSLLNGECDIALAGGVTVTLPEKSGYEYQEGMILSPDGKCRAFXXXXXXXXXXX 237 AVH+A QSLLNGECD+ALAGGV++ +P+ GY +QEG+I S DG CRAF Sbjct: 191 AVHLACQSLLNGECDMALAGGVSIQIPQNVGYLHQEGLIGSHDGHCRAFDARSSGTVFGN 250 Query: 238 XXXXXVLKRLQDALDDGDQIYAVIKGSAVNNDGLQKTGFTAPSTIGQAEVIRTALKLAEV 297 +LK LQDA+ DGD I+AVIKGSA+NNDG K G+TAPS GQA VI A +A V Sbjct: 251 GVGVVLLKPLQDAIADGDCIHAVIKGSAINNDGSLKLGYTAPSVDGQAAVISEAQAVASV 310 Query: 298 SPDSIDYIECHGTGTPLGDPIELEALELGYN--PERRHACALGSVKTNIGHLDSAAGIAS 355 +P++I YIE HGTGT LGDPIE+EAL ++ +++ CA+GS+KTN+GH+++AAGI + Sbjct: 311 TPETITYIEAHGTGTELGDPIEIEALTKAFSEHTDKKQFCAIGSLKTNVGHMNTAAGIGA 370 Query: 356 FIKTVLALKHNILPPSLHFQTPNPVLKVIEKGFYINDRLTEWPSKNEPLRAGISAFGIGG 415 IKTVL LKHN++PPSLH++ PNP + + FY+N L+EW PLRAG+S+FGIGG Sbjct: 371 LIKTVLTLKHNLIPPSLHYEKPNPQINFSDSPFYVNSTLSEWKRNGTPLRAGVSSFGIGG 430 Query: 416 TNAHIIVEQAPP--PREASAGREWQLLPVSAKTPSALAEIKQDLERYSKTE-PRRLEDIA 472 TN+H+++E+AP E R +L +SAKTP+ALA++ Y +T L D+ Sbjct: 431 TNSHVVLEEAPSQVKEEDDLQRPVHILTLSAKTPTALADLVDSYHHYLETNLDLDLGDVC 490 Query: 473 YTLQVGRKHFPIRELALVNRK----SQRVLQFAETATMKGTAG---LENAPVIFVIPDFT 525 YT GR HF R LA+V K ++++ QF ++G L NA V FT Sbjct: 491 YTANTGRVHFNHR-LAVVAEKQTELTEKLRQFKLEDKVEGICSGKLLINATAPKVAFLFT 549 Query: 526 QRXXXXXXXXXXXXXXXXXPGARRFLNQ---------VLGMMNRLVPDGAAVKLEDLRKR 576 + P R L++ V ++ + P+G + L + Sbjct: 550 GQ--GSQYVNMGKELYEQAPVFRAALDECEEILEELGVNSILEIIYPEGG--ETSPLDQT 605 Query: 577 EYHPVLAFGSYYAVGKLFIEWGLHPEAVIGRGKSQWLAACLSGELSLEEAVR 628 Y F YA+ KL+ WG+ P+ V+G +++AA ++G SLE+ ++ Sbjct: 606 AYTQPAIFAIEYALAKLWESWGIKPDVVMGHSVGEYIAATVAGIFSLEDGLK 657 Score = 139 bits (350), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 155/640 (24%), Positives = 270/640 (42%), Gaps = 82/640 (12%) Query: 757 DIRKWFYIPAWESAALPNYEGRMLSRDAAWFIFCDPGG-------LGEALGDLLRQQQIR 809 D +W+Y W+ AAL E + + +FC G ++L L Q + Sbjct: 1250 DFSQWYYQTEWQPAALMPGETQ---ETGTYLLFCPTGESNSKLKEWSDSLNSQLLDQGHQ 1306 Query: 810 CIMVEHAEHYQQITADHYR----VNPLRSEEMDRLYHSLDAVPDH-----ICYLWTVTSP 860 CI+V A+ Y++++++ + ++P + E +L ++ + + + +LW++ + Sbjct: 1307 CIVVYPADSYKKLSSEGKKQIIQLSPTQPEHFQKLLDEVNELTEELPLKGVIHLWSLDTD 1366 Query: 861 MEPELANIETGQQLFLHHILRLVQFLGTAAAAQEVHLQIVSNGLYSITQEEMLC----PM 916 +E EL E ++ I+ +Q + + + L L ++E + P Sbjct: 1367 VE-ELTKTE---EIICGSIINFLQGMRSLEKLPPLLLVTQGASLEVRSKESGVSINAQPQ 1422 Query: 917 KGLLLGASKIIPYEYPNIKVCHVDFPLAEGDP-ARQREQARQMLREFQFEFPN----KQV 971 + LL G K+I EYP + +D DP A ++E + +L E + Q+ Sbjct: 1423 QALLWGVGKVITMEYPQLDCRCLDL-----DPNADEQETLKVLLDEVANHQTSTSVENQI 1477 Query: 972 AYRGKSRWIEAVQKPLLLASPGKVSLFRNNLVCMITXXXXXXXXXXXXXXXTQYTARLVL 1031 Y R + + +P L + K+++ + +IT Q + L Sbjct: 1478 RYCQGKRQVARLTQPRL-DTDAKLAI-QTEASYLITGGLGALGLEVAQLLVQQGVKSIAL 1535 Query: 1032 VGRSAFPPKSEWDQWMNRPDDAEVARIIRTIRALEAAGAVIEVHSADISDFSAMQQVVAR 1091 VGR N P +E A+ +I+ LEAAG + V D+S M + + Sbjct: 1536 VGR-------------NSP--SETAQ--ESIQELEAAGTQVSVFLGDVSVEKDMVNIFQK 1578 Query: 1092 AEARLGPITGVLHTAGVADYAGVIQRRTQAMTDEVLLPKVKGTLVLDTLFRNRRLDFFVL 1151 + L P+ GV+H AGV D G IQ+ T +V PKV GT L L ++ LDFFV Sbjct: 1579 IQTSLPPLKGVIHAAGVLD-DGFIQQMTWQQFTKVTAPKVTGTWNLHKLTKDIPLDFFVC 1637 Query: 1152 FSSIGNYIYGRKFGQVGYNAANEFLDAFVHYRLQNREGFTATINWNDWAEAGMSVK--AM 1209 FSS+ + + GQ Y AAN F+DA YR QN +INW WA G++ + A Sbjct: 1638 FSSLASVLGSP--GQSNYAAANAFMDAVAQYR-QNLGLPGLSINWGPWANVGIAARMGAQ 1694 Query: 1210 EKNRSLHKAVNDLQFEAEAITTEQGVNVFRYIMENQMNRVIVSALDLPALMEESNNISVE 1269 ++ R + + +Q TEQG+ ++ ++ + +D P L+ + ++ Sbjct: 1695 QQGRLQSQGLQGIQ-------TEQGLQALEEVLATDEAQIAIFNIDWPHLLSQFGQMTPA 1747 Query: 1270 VILEQXXXXXXXXXXXXXXGSSSLLTE---AGLQQQIADIWSTVLGIEAIGI-------- 1318 + E LL + A Q+ + ++G+ A + Sbjct: 1748 FLSEIASQHPLQGKANQGPKQRELLEQMKVATTDQRQRLMVDYLIGVVAKVLRRGKNDLP 1807 Query: 1319 --DEDFFALGGDSLKAITIVSLVFKKLGVKLPLPAFFHKP 1356 +E FF LG DSL A+ ++ LG+ L + F P Sbjct: 1808 DPEEGFFNLGMDSLMALDFGQMIQVDLGITLSSTSTFEYP 1847 >ref|ZP_00106167.1| COG3321: Polyketide synthase modules and related proteins [Nostoc punctiforme] Length = 1538 Score = 491 bits (1265), Expect = e-137, Method: Compositional matrix adjust. Identities = 285/720 (39%), Positives = 416/720 (57%), Gaps = 42/720 (5%) Query: 1 LEIAVIGLAGRFPGAGTISEYWDNLKNGVHSVQTFSEQELIAAGVEPGLAAKAEYVKAKG 60 LE+A+IGLAGRFPGA I E+W NL++GV SV+ FS++EL+AAG+EP L +++ YVKA Sbjct: 8 LEVAIIGLAGRFPGAKNIEEFWRNLQDGVESVKFFSDEELLAAGIEPALLSQSNYVKAGA 67 Query: 61 YLEAGHCFDARFFDYTPLEAELMDPQMKVFHECIWXXXXXXXXXXXXXQQLIGLFAGASP 120 L FDA FF YTP EAE+++PQ ++F EC + IG++A Sbjct: 68 ILNDIEMFDAAFFGYTPREAEILNPQHRLFLECADEALENAAYNPQTYKSPIGVYAAVGK 127 Query: 121 NHVWEGLMGLSGKSGVMGHWAASQLL--DKDYLSLRIAHKLNLKGPALSIYTACSTSLVA 178 N L + S ++ S +L + DYLS +++KL+L G ++++ TACS+SLVA Sbjct: 128 NDYL--LDNIYPNSDLIEAVGVSPILIANGDYLSTLVSYKLDLSGASITVQTACSSSLVA 185 Query: 179 VHMAAQSLLNGECDIALAGGVTVTLPEKSGYEYQEGMILSPDGKCRAFXXXXXXXXXXXX 238 VH+A Q LL+G+C++ALAGGV++ LP+ SGY YQEG I+S DG CR F Sbjct: 186 VHLACQGLLSGDCEMALAGGVSIRLPQMSGYIYQEGGIVSVDGHCRTFDAKAKGAVGGNG 245 Query: 239 XXXXVLKRLQDALDDGDQIYAVIKGSAVNNDGLQKTGFTAPSTIGQAEVIRTALKLAEVS 298 VLKRL++A+ DGD+IYAVIKGSA+NNDG QK G+TAP GQA VI A +E++ Sbjct: 246 LGIVVLKRLENAIKDGDRIYAVIKGSAINNDGAQKIGYTAPGVEGQANVILAAQATSEIA 305 Query: 299 PDSIDYIECHGTGTPLGDPIELEALELGY--NPERRHACALGSVKTNIGHLDSAAGIASF 356 ++I YIE HGT TPLGDPIELEAL + + ++ CA+GS+KTN+GHLD+AAG+A Sbjct: 306 AETITYIEAHGTATPLGDPIELEALTQAFRTSTAKKGFCAIGSLKTNMGHLDAAAGVAGL 365 Query: 357 IKTVLALKHNILPPSLHFQTPNPVLKVIEKGFYINDRLTEWPSKNEPLRAGISAFGIGGT 416 IKT LAL+H ++P SL+F+ PN + FY+N +L++W S N P R+G+S+FGIGGT Sbjct: 366 IKTTLALQHKVIPASLNFEQPNSKIDFANSPFYVNTKLSKWDSVNTPRRSGVSSFGIGGT 425 Query: 417 NAHIIVEQAPPPREAS-----AGREWQLLPVSAKTPSALAEIKQDLERYSKTEPR-RLED 470 NAH+I+E++P + GR++ LL VSAKT SAL + +L Y + P L D Sbjct: 426 NAHLILEESPLLEQEDRGAEEQGRKYHLLIVSAKTDSALETMTVNLAEYLQQHPDINLAD 485 Query: 471 IAYTLQVGRKHFPIR--------ELALVNRKSQRVLQFAETATMKGTAGLENAPVIFVIP 522 + +TLQVGR+ + R E A++ K+ Q+ T K PV F+ P Sbjct: 486 VVHTLQVGRRTYNHRRMLVCRNLESAIIGLKASEPSQYLTTFQEK-----TQRPVTFLFP 540 Query: 523 ----DFTQRXXXXXXXXXXXXXXXXXPGARRFLNQVLGMMNRLVPDGAAVKLEDLRKREY 578 + +N L + L P+ + + + ++ Sbjct: 541 GQGSQYVNMARELYEVEPTFQTEFDHCAQLLLINFGLDLHRLLYPEASVQETAQAQLQQT 600 Query: 579 H---PVLAFGSYYAVGKLFIEWGLHPEAVIGRGKSQWLAACLSGELSLEEAVRSFLLSLD 635 H P L F YA+ KL++ WG+ P+A+IG +++AACL+G SLE+ + + +++ Sbjct: 601 HLTQPAL-FVIEYALAKLWMSWGIKPQAMIGHSIGEYVAACLAGVFSLEDGL-TLVITRA 658 Query: 636 ECGMERPEAGRRSSRREEIWLVLGAGNEAQPFLDKQSSKPQIIALEKLNTYSLMAAVGTM 695 + E P+ + E +E +P L++Q S I A + L A+ T+ Sbjct: 659 KLMQELPKGAMLAVPLPE--------SEIKPLLNEQLSLAAINAPSQCVVSGLADAIATL 710 Score = 290 bits (742), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 208/724 (28%), Positives = 347/724 (47%), Gaps = 48/724 (6%) Query: 652 EEIWLVLGAGNEAQPFLDKQSSKPQ-IIALEKL--------NTYSLMAAVGTMWLYGQDI 702 + ++L +G G F+ + S K I AL L + L +G +WL G ++ Sbjct: 800 DRVFLEVGPGRTLSTFIQQHSDKNTGITALASLRHPRDESSDVAFLQNTLGQLWLAGVEV 859 Query: 703 KWRELYQHEQRNRLSLPTYAFDRQEFPVD-PELFNLNHLLNRPPSGKGGTPADRDDIRKW 761 W LY HE+R RL+LPTY F+RQ + +D P + PS P + DI KW Sbjct: 860 DWSGLYIHERRQRLALPTYPFERQRYWLDAPNSAEI-------PSSPQLLPNKKLDISKW 912 Query: 762 FYIPAWESAALPNYEGRMLSRDAAWFIFCDPGGLGEALGDLLRQQQIRCIMVEHAEHYQQ 821 YIP+W+ P+ R S +F D GLG + L + I ++ + Q Sbjct: 913 LYIPSWKRTVSPS---RRHSSPGCTLVFSDDCGLGLGIVRQLELEGETVITLKVGSEFHQ 969 Query: 822 ITADHYRVNPLRSEEMDRLY---HSLDAVPDHICYLWTVTSPMEPEL--ANIETGQQLFL 876 I+ Y +NP ++ D L H P I +LW+VT PEL A + Q+ Sbjct: 970 ISERLYSLNPKNHQDYDTLLQELHRQGLQPQKIIHLWSVTENYTPELEIAEFDKAQETGF 1029 Query: 877 HHILRLVQFLGTAAAAQEVHLQIVSNGLYSITQEEMLCPMKGLLLGASKIIPYEYPNIKV 936 + +L L Q L E+ + +VSN + +T +++CP K +LG K+IP EYPNI Sbjct: 1030 YSLLFLAQTLAKHHVIDELQITVVSNNVQQVTGVDIVCPAKATILGPVKVIPQEYPNITC 1089 Query: 937 CHVDFPLAEGDPARQREQARQMLREFQFEFPNKQVAYRGKSRWIEAVQKPLLLASPGKVS 996 ++D + + + Q + Q++ E + +K +AYRG R ++ + S Sbjct: 1090 RNIDIIIPK---SSQDKLVEQIVAELTCDNLDKVIAYRGYHRLVQTFEPVQWDESVVGTP 1146 Query: 997 LFRNNLVCMITXXXXXXXXXXXXXXXTQYTARLVLVGRSAFPPKSEWDQWMNRPDDAE-V 1055 R V +IT L+L+GRS FP K W+QW+ D + + Sbjct: 1147 RLREKGVYLITGGLGKISLLLAEHLAKTVQGNLILIGRSPFPAKDSWEQWLVNHDHTDSI 1206 Query: 1056 ARIIRTIRALEAAGAVIEVHSADISDFSAMQQVVARAEARLGPITGVLHTAGVADYAGVI 1115 ++ I+ + +E+ G + + +AD+S+ MQ + A+ + G + GV+H +AD I Sbjct: 1207 SQKIQKLIEIESFGGKVLIINADVSNQQQMQAAIDLAKEKYGRVNGVIHAVAIADSFHAI 1266 Query: 1116 QRRTQAMTDEVLLPKVKGTLVLDTLFRNRRLDFFVLFSSIGNYIYGRKFGQVGYNAANEF 1175 ++ + + PK+ G LVL+ +F+N++LDF +L SS+ + + G F V Y+AAN F Sbjct: 1267 EQTSYQECLQQFQPKIHGLLVLEKIFQNQKLDFCLLLSSLSSILGGLGF--VAYSAANNF 1324 Query: 1176 LDAFVHYRLQNREGFTATINWNDWAEAGMSVKAMEKNRSLHKAVNDLQFEAE-AITTEQG 1234 LD F H N +INW+ W + S K +L AE A+ ++G Sbjct: 1325 LDIFAHKYNPNNSIPWISINWDAW-----------QFDSEPKITGNL---AELALNPQEG 1370 Query: 1235 VNVFRYIMEN-QMNRVIVSALDLPALMEESNNISVEVILEQXXXXXXXXXXXXXXGSSSL 1293 + +F+YI +N+ +VS +L A +++ + + + ++ Sbjct: 1371 IKIFQYIFSQPDVNQWVVSTGNLQARIDQWIQLKILGNRKDLKSASSITHHARPNLRNAY 1430 Query: 1294 LTEAG-LQQQIADIWSTVLGIEAIGIDEDFFALGGDSLKAITIVSLVFKKLGVKLPLPAF 1352 + + +++ + +IW +LGIE IGI+++FF LGG+SL AI I+S + + + LP+ F Sbjct: 1431 IAPSNEIEKCLVNIWQDLLGIEPIGIEDNFFELGGNSLTAIQIISRLREIYLIDLPVNDF 1490 Query: 1353 FHKP 1356 F P Sbjct: 1491 FETP 1494 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.320 0.137 0.410 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 2,180,247,957 Number of extensions: 87614036 Number of successful extensions: 206697 Number of sequences better than 1.0e-05: 2356 Number of HSP's gapped: 196984 Number of HSP's successfully gapped: 3605 Length of query: 1557 Length of database: 757,237,578 Length adjustment: 139 Effective length of query: 1418 Effective length of database: 379,838,817 Effective search space: 538611442506 Effective search space used: 538611442506 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 133 (55.8 bits)