BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0489.0015.p (2806 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value sp|O30409|TYCC_BREPA Tyrocidine synthetase III [Includes: ATP-de... 679 0.0 gb|AAB80956.1| fengycin synthetase FenE [Bacillus subtilis] 665 0.0 ref|NP_389714.1| peptide synthetase [Bacillus subtilis] >gi|6093... 661 0.0 sp|O30408|TYCB_BREPA Tyrocidine synthetase II [Includes: ATP-dep... 656 0.0 emb|CAE02630.1| surfactin synthetase A [Bacillus amyloliquefaciens] 648 0.0 >sp|O30409|TYCC_BREPA Tyrocidine synthetase III [Includes: ATP-dependent asparagine adenylase (AsnA) (Asparagine activase); ATP-dependent glutamine adenylase (GlnA) (Glutamine activase); ATP-dependent tyrosine adenylase (TyrA) (Tyrosine activase); ATP-dependent valine adenylase (ValA) (Valine activase); ATP-dependent ornithine adenylase (OrnA) (Ornithine activase); ATP-dependent leucine adenylase (LeuA) (Leucine activase)] pir||T31076 tyrocidine synthetase 3 - Brevibacillus brevis gb|AAC45930.1| tyrocidine synthetase 3 [Brevibacillus brevis] Length = 6486 Score = 679 bits (1751), Expect = 0.0, Method: Compositional matrix adjust. Identities = 391/1135 (34%), Positives = 625/1135 (55%), Gaps = 36/1135 (3%) Query: 1642 EKKLCAIYENHLGFQPIGIEDDFFELSGDSLKAIHVISSIRKQFDCNLTLTDFFQNKTIK 1701 E KL AI+E+ LG +PIG+ D FFEL G SLKA+HVIS +++ F ++ L F++ TI Sbjct: 2008 EAKLAAIWESVLGVEPIGVHDHFFELGGHSLKAMHVISLLQRSFQVDVPLKVLFESPTIA 2067 Query: 1702 SVARFIRNASRANERQIAPVNPKSHYPTSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNI 1761 +A + A + I PV + +YP S AQKR+F LQ + + YN + L+G + Sbjct: 2068 GLAPLVAAARKGTYTAIPPVEKQEYYPVSAAQKRMFILQQMEGAGISYNMPGFMYLDGKL 2127 Query: 1762 NAGRIEEVFAQIINRHESLRTSFRAENGEIVQIIHPHVDFKLIRTAVKEQGIEEAVERFI 1821 + R+++ ++ RHESLRTSF + GE VQ +H VD + E + E+FI Sbjct: 2128 DTERLQQALKSLVQRHESLRTSFHSVQGETVQRVHDDVDLAISFGEATEAETRQIAEQFI 2187 Query: 1822 QPFDLARAPLIRVGLLQAGEQQSILVVDMHHIIADGTSVNLLVNDFADLYMGKILPPLAI 1881 QPFDL APL+R GL++ ++ + ++D+HHI+ DG S+ LL+ +FA LY G+ LP L I Sbjct: 2188 QPFDLGTAPLLRAGLIKLAPERHLFMLDLHHIVVDGVSIGLLIEEFAQLYHGEELPALRI 2247 Query: 1882 QYKDYAEWQQGFITSEAYRSKETYWLEKLAGPLPVLTLPTDYPRPAALSFQGGRITLELD 1941 QYKD+A+WQQ + +E + +E YWL G +PVL LPTDYPRP+ SF G R Sbjct: 2248 QYKDFAKWQQDWFQTEEFAEQEAYWLNTFTGEIPVLNLPTDYPRPSVKSFAGDRFVFGSG 2307 Query: 1942 RPSSERIKKFSQEQQVTWFMTMXXXXXXXXXXXSGESDILIGIPQAGRNHEDVQEMVGMF 2001 +++ + +QE T +M + S + DI++G P AGR+H + + +VGMF Sbjct: 2308 TALPKQLHQLAQETGTTLYMVLLAAYNVLLSKYSRQEDIIVGAPTAGRSHAETESIVGMF 2367 Query: 2002 VNSLVLRNQPXXXXERKKPFLAFLQEVRASLLEALENQDFQIEMIVDQLDYKRDPGRTFL 2061 VN+L LRN+P K F FL EV+ + L A E+QD+ ++ +VD+LD +RD R L Sbjct: 2368 VNTLALRNEPAG----GKTFRDFLAEVKINTLGAFEHQDYPLDELVDKLDMQRDLSRNPL 2423 Query: 2062 YDTIFNYQSMKNQTETEASYLHDMKLSPYPMTSKTTKADLNIHLYEVPSGIYVECFYRTD 2121 +DT+F Q+M E + + + ++PY K K DL++ YE + I Y T Sbjct: 2424 FDTVFILQNM----EQKPFEMEQLTITPYSAEVKQAKFDLSLEAYEENAEIIFSLDYSTK 2479 Query: 2122 LFKRETVQYIFEEYRRLIEAIPEQAGRTIGELPVFRQNDIPPAGGNVSPPVRFQAFHYND 2181 LF RET++ I + +++ A+ + + E+ + + + V F H + Sbjct: 2480 LFSRETIEKIATHFIQILRAVIAEPEMPLSEITMLTEAE------KQRLLVDFNGAHKDF 2533 Query: 2182 PAENLVQR-FEKQVAAYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVA 2240 P +Q FE+Q P TAV+ + L+Y++LNE+AN++A + E Q ++PV Sbjct: 2534 PQNKTLQALFEEQAEKSPQATAVEISGQPLSYQELNERANQLAATLRERGVQP--DQPVG 2591 Query: 2241 LLFGNTIEMVAALAGAIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSENESIAREL 2300 ++ ++EMV + +KAG +VP+D P +R+ +M+ D QA L+LT + + +L Sbjct: 2592 IMANRSVEMVVGILAILKAGGAYVPIDPEYPEERVAYMLTDCQARLVLT---QKHLGAKL 2648 Query: 2301 AERVHAKVTIVNTAEGLSGVSAENPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFY 2360 V A+ ++ E GV N A+I+YTSG++G PKGV+ +R I Sbjct: 2649 GSSVTAECLYLDD-ESNYGVHRSNLQPINTASDLAYIIYTSGTTGKPKGVMVEHRGIVNN 2707 Query: 2361 IAQFTHSLAVNHQDRMALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSSWLN 2420 + + DR L +++ +L +L+GAT+ L + + L + Sbjct: 2708 VLWKKAEYQMKVGDRSLLSLSFAFDAFVLSFFTPVLSGATVVLAEDEEAKDPVSLKKLIA 2767 Query: 2421 SEGITLYHSVPSVFRFLMK-NLPGDVKLPSLRMVLLGGEVVTRADFELYKKNCAEHCLFV 2479 + TL VPS+F+ +++ + P D++ L+ V LGGE +T E K+ + V Sbjct: 2768 ASRCTLMTGVPSLFQAILECSTPADIR--PLQTVTLGGEKITAQLVEKCKQ-LNPDLVIV 2824 Query: 2480 NFLGCSELMVISFYTLDKGSEVNHARLPAGYAVDGIDVRIVGESGREAGIFEVGQLVYQS 2539 N G +E V++ + G + A + G + + IV + + I VG++ Sbjct: 2825 NEYGPTESSVVATWQRLAGPD---AAITIGRPIANTSLYIVNQYHQLQPIGVVGEICIGG 2881 Query: 2540 EYLSPGYWNQAGVTERVFASGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYR 2599 L+ GYWN+ +TE F S P + +R+Y++GD G+ LP+G +EY GR D Q+K+RGYR Sbjct: 2882 RGLARGYWNKPALTEEKFVSHPFAAGERMYKTGDLGKWLPDGTIEYIGRIDEQVKVRGYR 2941 Query: 2600 VDLNEIESTLDHIPFIQQSIVTATLDHEGEQAIAAYYVLKEPAAEKDIIRL---LREQLP 2656 +++ EIES L + ++V D G+ A+AAY+ E + D+ +L L ++LP Sbjct: 2942 IEIGEIESALLAAEKLTAAVVVVYEDQLGQSALAAYFTADE---QLDVTKLWSHLSKRLP 2998 Query: 2657 AYLIPRYWIELKFFPMTGPNKVDRNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWGEV 2716 +Y+IP ++++L P+T KVD+ ALP P+ P + +YV P N +E+ LA +W V Sbjct: 2999 SYMIPAHFVQLDQLPLTPNGKVDKKALPKPEGKPVTE--AQYVAPTNAVESKLAEIWERV 3056 Query: 2717 LGIQHIGVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTISSLATFL 2771 LG+ IG+ D FF+IGGHSL M V + +E ++ + + LF PTI +LA ++ Sbjct: 3057 LGVSGIGILDNFFQIGGHSLKAMAVAAQVHREYQVELPLKVLFAQPTIKALAQYV 3111 Score = 655 bits (1689), Expect = 0.0, Method: Compositional matrix adjust. Identities = 386/1165 (33%), Positives = 623/1165 (53%), Gaps = 40/1165 (3%) Query: 1618 PVTRKSQGKRPELP---------VAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELS 1668 P+T + +R +LP AY + E KL I++ LG +GI DDFF+L Sbjct: 938 PLTANGKVERKKLPKPAGAVVTGTAYAAPQNEIEAKLAEIWQQVLGISQVGIHDDFFDLG 997 Query: 1669 GDSLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYP 1728 G SLKA+ V+ + K + L + F++ T+ +ARF+ + + I PV + YP Sbjct: 998 GHSLKAMTVVFQVSKALEVELPVKALFEHPTVAELARFLSRSEKTEYTAIQPVAAQEFYP 1057 Query: 1729 TSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAEN 1788 S AQKR++ LQ + + YN S ++LLEG ++ R Q+ RHE+LRTSF + Sbjct: 1058 VSSAQKRMYILQQFEGNGISYNISGAILLEGKLDYARFASAVQQLAERHEALRTSFHRID 1117 Query: 1789 GEIVQIIHPHVDFKLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVV 1848 GE VQ +H V+ L E E+ + F++PFDL APL+R GLL+ G+ + + ++ Sbjct: 1118 GEPVQKVHEEVEVPLFMLEAPEDQAEKIMREFVRPFDLGVAPLMRTGLLKLGKDRHLFLL 1177 Query: 1849 DMHHIIADGTSVNLLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLE 1908 DMHHII+DG S +L+ +FA+LY G L PL++QYKD+A WQ +EAY+ +E +WL Sbjct: 1178 DMHHIISDGVSSQILLREFAELYQGADLQPLSLQYKDFAAWQNELFQTEAYKKQEQHWLN 1237 Query: 1909 KLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXX 1968 A +P+L LPTDYPRP+ SF G + + ER+++ + E T +M + Sbjct: 1238 TFADEIPLLNLPTDYPRPSVQSFAGDLVLFAAGKELLERLQQVASETGTTLYMILLAAYN 1297 Query: 1969 XXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEV 2028 +G+ DI++G P AGR+H DV+ ++G+FVN+L LRNQP K F FLQEV Sbjct: 1298 VLLSKYTGQEDIIVGTPVAGRSHADVENIMGIFVNTLALRNQPAS----SKTFAQFLQEV 1353 Query: 2029 RASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLS 2088 + + L A ++QD+ E +V++L +RD R L+DT+F+ ++ Q+ A ++ S Sbjct: 1354 KQNALAAYDHQDYPFEELVEKLAIQRDISRNPLFDTLFSLENANQQSLAIA----ELTAS 1409 Query: 2089 PYPMTSKTTKADLNIHLYEVPSGIYVECFYRTDLFKRETVQYIFEEYRRLIEAIPEQAGR 2148 PY + +K +K DL ++ E P+ I + + T LFK+ETV+ + Y ++ I EQ Sbjct: 1410 PYELFNKISKFDLALNASESPADIQFQLTFATKLFKKETVERMARHYLEILRWISEQPTA 1469 Query: 2149 TIGELPVFRQNDIPPAGGNVSPPVRFQAFHYNDPAENLVQRFEKQVAAYPAHTAVKYREE 2208 ++ ++ + + + NV+ F A L Q E+Q A P AV Y E Sbjct: 1470 SLADIDMMTEAEKRTLLLNVN-----DTFVERTAATALHQLVEEQAARTPDEVAVVYEEY 1524 Query: 2209 SLNYRQLNEQANRIARRIWELKEQESVERPVALLFGNTIEMVAALAGAIKAGIPFVPLDR 2268 +L YR+LN +AN++AR + + + ++ + MV + +KAG + P+D Sbjct: 1525 ALTYRELNARANQLARLLR--SHGTGPDTLIGIMVDRSPGMVVGMLAVLKAGGAYTPIDP 1582 Query: 2269 SAPLQRLIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNTAEGLSGVSAE-NPSV 2327 S P +R+ +M++D+QA ++LT R L E + I++ E A+ N Sbjct: 1583 SYPPERIQYMLSDSQAPILLTQ-------RHLQELAAYQGEIIDVDEEAIYTGADTNLDN 1635 Query: 2328 CPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQDRMALLTTYSHAIG 2387 D A+++YTSGS+G PKGV+ S++ I ++ + + +D + T +S Sbjct: 1636 VAGKDDLAYVIYTSGSTGNPKGVMISHQAICNHMLWMRETFPLTTEDAVLQKTPFSFDAS 1695 Query: 2388 ILDILASLLNGATLHLCDLKLDASIQRLSSWLNSEGITLYHSVPSVFRFLMKNLPGDVKL 2447 + + L+ G L L I ++ + E IT VPS+ +M + PG Sbjct: 1696 VWEFYLPLITGGQLVLAKPDGHRDIAYMTRLIRDEKITTLQMVPSLLDLVMTD-PGWSAC 1754 Query: 2448 PSLRMVLLGGEVVTRADFELYKKNCAEHCLFVNFLGCSELMV-ISFYTLDKGSEVNHARL 2506 SL+ V GGE +T A + + + +N G +E + +++ + E ++ + Sbjct: 1755 TSLQRVFCGGEALTPALVSRFYET--QQAQLINLYGPTETTIDATYWPCPRQQE--YSAI 1810 Query: 2507 PAGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQAGVTERVFASGPDSGAK 2566 P G +D + + +V S + + G+L + L+ GYW + +T+ F P Sbjct: 1811 PIGKPIDNVRLYVVNASNQLQPVGVAGELCIAGDGLARGYWQREELTKASFVDNPFEPGG 1870 Query: 2567 RLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATLDH 2626 +YR+GD R LP+G +EY GR D Q+KIRG+R++L EIE+TL ++ +V A D Sbjct: 1871 TMYRTGDMVRYLPDGHIEYLGRIDHQVKIRGHRIELGEIEATLLQHEAVKAVVVMARQDG 1930 Query: 2627 EGEQAIAAYYVLKEPAAEKDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNALPAP 2686 +G+ ++ AY V ++ ++ L LPAY++P ++ L+ P++ KVDR ALP P Sbjct: 1931 KGQNSLYAYVVAEQDIQTAELRTYLSATLPAYMVPSAFVFLEQLPLSANGKVDRKALPQP 1990 Query: 2687 DAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNNLE 2746 + + YV PRNE E LA +W VLG++ IGV D FFE+GGHSL M V + L+ Sbjct: 1991 E--DAAASAAVYVAPRNEWEAKLAAIWESVLGVEPIGVHDHFFELGGHSLKAMHVISLLQ 2048 Query: 2747 KELKLTVEMGDLFKYPTISSLATFL 2771 + ++ V + LF+ PTI+ LA + Sbjct: 2049 RSFQVDVPLKVLFESPTIAGLAPLV 2073 Score = 645 bits (1665), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/1162 (32%), Positives = 613/1162 (52%), Gaps = 50/1162 (4%) Query: 1622 KSQGKRPELPVAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGDSLKAIHVISSI 1681 K +GK P YV E KL I+E LG IGI D+FF++ G SLKA+ V + + Sbjct: 3027 KPEGK-PVTEAQYVAPTNAVESKLAEIWERVLGVSGIGILDNFFQIGGHSLKAMAVAAQV 3085 Query: 1682 RKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYPTSLAQKRIFFLQG 1741 +++ L L F TIK++A+++ + + I P + +YP S AQKR++ L+ Sbjct: 3086 HREYQVELPLKVLFAQPTIKALAQYVATSGKETYVPIEPAPLQEYYPVSSAQKRMYVLRQ 3145 Query: 1742 LMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAENGEIVQIIHPHVDF 1801 YN +++ +EG+++ R E ++ RHESLRTSF NGE VQ +H HV+ Sbjct: 3146 FADTGTVYNMPSALYIEGDLDRKRFEAAIHGLVERHESLRTSFHTVNGEPVQRVHEHVEL 3205 Query: 1802 KLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVVDMHHIIADGTSVN 1861 + V E +E VE F+Q FDL +APL+RVGL + ++ + ++DMHHII+DG S Sbjct: 3206 NVQYAEVTEAQVEPTVESFVQAFDLTKAPLLRVGLFKLAAKRHLFLLDMHHIISDGVSAG 3265 Query: 1862 LLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLEKLAGPLPVLTLPT 1921 +++ +F+ LY G+ LP L++ YKD+A WQ S+ Y E YWL +G +PVL LP Sbjct: 3266 IIMEEFSKLYRGEELPALSVHYKDFAVWQSELFQSDVYTEHENYWLNAFSGDIPVLNLPA 3325 Query: 1922 DYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXXXXXXXXSGESDIL 1981 D+ RP SF+G ++ + D+ + + K +QE Q T FM + SG+ DI+ Sbjct: 3326 DFSRPLTQSFEGDCVSFQADKALLDDLHKLAQESQSTLFMVLLAAYNVLLAKYSGQEDIV 3385 Query: 1982 IGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEVRASLLEALENQDF 2041 +G P AGR+H D++ ++GMFVN+L LRN P K F AFL+EV+ + L+A +QD+ Sbjct: 3386 VGTPIAGRSHADIENVLGMFVNTLALRNYPV----ETKHFQAFLEEVKQNTLQAYAHQDY 3441 Query: 2042 QIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLSPYPMTSKTTKADL 2101 E +V++LD +RD R L+DT+F Q++ + +A L +KL YP + K DL Sbjct: 3442 PFEALVEKLDIQRDLSRNPLFDTMFILQNL----DQKAYELDGLKLEAYPAQAGNAKFDL 3497 Query: 2102 NIHLYEVPSGIYVECFYRTDLFKRETVQYIFEEYRRLIEAIPEQAGRTIGELPVFRQNDI 2161 + +E +GI+ Y T LF+RE+++ + + +++ + + E+ + + + Sbjct: 3498 TLEAHEDETGIHFALVYSTKLFQRESIERMAGHFLQVLRQVVADQATALREISLLSEEE- 3556 Query: 2162 PPAGGNVSPPVRFQAFHYND-----PAENLVQR-FEKQVAAYPAHTAVKYREESLNYRQL 2215 R +N+ P + +Q FE+Q A P H AV + L YR+L Sbjct: 3557 ----------RRIVTVDFNNTFAAYPRDLTIQELFEQQAAKTPEHAAVVMDGQMLTYREL 3606 Query: 2216 NEQANRIARRIWELKEQESV--ERPVALLFGNTIEMVAALAGAIKAGIPFVPLDRSAPLQ 2273 NE+AN++A + Q V E V LL ++EM+ + G +KAG ++ LD P + Sbjct: 3607 NEKANQLAHVL----RQNGVGKESIVGLLADRSLEMITGIMGILKAGGAYLGLDPEHPSE 3662 Query: 2274 RLIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNTAEGLSGVSAENPSVCPDGDQ 2333 RL +M+ D ++L + E + IV E L NP++ Sbjct: 3663 RLAYMLEDGGVKVVLVQKHLLPLVGE------GLMPIVLEEESLRPEDCGNPAIVNGASD 3716 Query: 2334 TAFILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQDRMALLTTYSHAIGILDILA 2393 A+++YTSGS+G PKGV+ +RN+ + T+ + V DRM +I Sbjct: 3717 LAYVMYTSGSTGKPKGVMVEHRNVTRLVMH-TNYVQVRESDRMIQTGAIGFDAMTFEIFG 3775 Query: 2394 SLLNGATLHLC--DLKLDASIQRLSSWLNSEGITLYHSVPSVFRFLMKNLPGDVKLPSLR 2451 +LL+GA+L+L D+ LDA ++L +L + IT +F L ++ P SLR Sbjct: 3776 ALLHGASLYLVSKDVLLDA--EKLGDFLRTNQITTMWLTSPLFNQLSQDNPA--MFDSLR 3831 Query: 2452 MVLLGGEVVTRADFELYKKNCAEHCLFVNFLGCSELMVISFYTLDKGSEVNHARLPAGYA 2511 +++GGE ++ K + ++ + + Y +++ E ++P G Sbjct: 3832 ALIVGGEALSPKHINRVKSALPDLEIWNGYGPTENTTFSTCYLIEQHFE---EQIPIGKP 3888 Query: 2512 VDGIDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQAGVTERVFASGPDSGAKRLYRS 2571 + IV + + I G+L + ++ GY N+ +T F P + + +YR+ Sbjct: 3889 IANSTAYIVDGNNQPQPIGVPGELCVGGDGVARGYVNKPELTAEKFVPNPFAPGETMYRT 3948 Query: 2572 GDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATLDHEGEQA 2631 GD R LP+G +EY GR D Q+KIRGYR++L EIE+ L +++++V + G++A Sbjct: 3949 GDLARWLPDGTIEYLGRIDQQVKIRGYRIELGEIETVLSQQAQVKEAVVAVIEEANGQKA 4008 Query: 2632 IAAYYVLKEPAAEKDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNALPAPDAIPS 2691 + AY+V ++ ++ + +QLP Y++P Y+++++ P+T KVDR ALP P Sbjct: 4009 LCAYFVPEQAVDAAELREAMSKQLPGYMVPAYYVQMEKLPLTANGKVDRRALPQPSG--E 4066 Query: 2692 NDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNNLEKELKL 2751 +V +N+ E L ++W EVLGI IG+ D FFEIGGHSL M V + K ++ Sbjct: 4067 RTTGSAFVAAQNDTEAKLQQIWQEVLGIPAIGIHDNFFEIGGHSLKAMNVITQVHKTFQV 4126 Query: 2752 TVEMGDLFKYPTISSLATFLKD 2773 + + LF PTI LA + + Sbjct: 4127 ELPLKALFATPTIHELAAHIAE 4148 Score = 632 bits (1631), Expect = e-179, Method: Compositional matrix adjust. Identities = 411/1207 (34%), Positives = 636/1207 (52%), Gaps = 81/1207 (6%) Query: 1618 PVTRKSQGKRPELP---------VAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELS 1668 P+T + R LP YV + E +L ++E L +G DDFF L Sbjct: 5092 PLTANGKVDRRSLPAPDVTMLRTTEYVAPRSVWEARLAQVWEQVLNVPQVGALDDFFALG 5151 Query: 1669 GDSLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYP 1728 G SL+A+ V+SS+ ++ ++ L F+ TI+ +A FI ++ N I PV +++YP Sbjct: 5152 GHSLRAMRVLSSMHNEYQVDIPLRILFEKPTIQELAAFIEETAKGNVFSIEPVQKQAYYP 5211 Query: 1729 TSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAEN 1788 S AQKR++ L + YN +++L+EG + R+E F ++I RHESLRTSF N Sbjct: 5212 VSSAQKRMYILDQFEGVGISYNMPSTMLIEGKLERTRVEAAFQRLIARHESLRTSFAVVN 5271 Query: 1789 GEIVQIIHPHVDFKLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVV 1848 GE VQ IH V F L + V EQ E V +QPFDL APLIRV LL+ GE + +L Sbjct: 5272 GEPVQNIHEDVPFALAYSEVTEQEARELVSSLVQPFDLEVAPLIRVSLLKIGEDRYVLFT 5331 Query: 1849 DMHHIIADGTSVNLLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLE 1908 DMHH I+DG S +L+ ++ LY G +LP L IQYKD+A WQQ F S A+ +E YWL+ Sbjct: 5332 DMHHSISDGVSSGILLAEWVQLYQGDVLPELRIQYKDFAVWQQEFSQSAAFHKQEAYWLQ 5391 Query: 1909 KLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXX 1968 A +PVL LPTD+ RP+ SF G + T+ + +E + + +Q T +M + Sbjct: 5392 TFADDIPVLNLPTDFTRPSTQSFAGDQCTIGAGKALTEGLHQLAQATGTTLYMVLLAAYN 5451 Query: 1969 XXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEV 2028 +G+ DI++G P GR+H D++ +VGMFVN+L +RN+P +R+K F FLQEV Sbjct: 5452 VLLAKYAGQEDIIVGTPITGRSHADLEPIVGMFVNTLAMRNKP----QREKTFSEFLQEV 5507 Query: 2029 RASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLS 2088 + + L+A +QD+ E +V++L RD R L+DT+F +Q N TE E L + L+ Sbjct: 5508 KQNALDAYGHQDYPFEELVEKLAIARDLSRNPLFDTVFTFQ---NSTE-EVMTLPECTLA 5563 Query: 2089 PYPMTSKT---TKADLNIHLYEVPSGIYVECFYRTDLFKRETVQYIFEEYRRLIEAIPEQ 2145 P+ MT +T K DL E + + Y T LF RET++ + + +I + Sbjct: 5564 PF-MTDETGQHAKFDLTFSATEEREEMTIGVEYSTSLFTRETMERFSRHFLTIAASIVQN 5622 Query: 2146 AGRTIGE----LPVFRQNDIPPAGGNVSPPVRFQAFHYNDPA------ENLVQRFEKQVA 2195 +GE LP +Q + AG +ND A + L Q FE+QV Sbjct: 5623 PHIRLGEIDMLLPEEKQQIL--AG-------------FNDTAVSYALDKTLHQLFEEQVD 5667 Query: 2196 AYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVALLFGNTIEMVAALAG 2255 P A+ + E+SL Y +LNE+ANR+AR + + +R VA++ + EMV + G Sbjct: 5668 KTPDQAALLFSEQSLTYSELNERANRLARVLR--AKGVGPDRLVAIMAERSPEMVIGILG 5725 Query: 2256 AIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNTAE 2315 +KAG +VP+D P +R+ +++ D+ A L+L+ + + +++ + + + AE Sbjct: 5726 ILKAGGAYVPVDPGYPQERIQYLLEDSNAALLLSQAHLLPLLAQVSSELPECLDL--NAE 5783 Query: 2316 GLSGVSAENPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQDR 2375 +G+S N A+++YTSG++G PKGV+ ++ I + D+ Sbjct: 5784 LDAGLSGSNLPAVNQPTDLAYVIYTSGTTGKPKGVMIPHQGIVNCLQWRRDEYGFGPSDK 5843 Query: 2376 MALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQ---RLSSWLNSEGITLYHSVPS 2432 + +++ + + A LL GAT C L +A+ + L + + +T Y+ VPS Sbjct: 5844 ALQVFSFAFDGFVASLFAPLLGGAT---CVLPQEAAAKDPVALKKLMAATEVTHYYGVPS 5900 Query: 2433 VFRFLMKNLPGDVKLPSLRMVLLGGEVVTRADFELYKKNCAEH--CLFVNFLGCSELMVI 2490 +F+ ++ + LR V LGGE + +L +K +H N G +E V+ Sbjct: 5901 LFQAIL-DCSTTTDFNQLRCVTLGGE---KLPVQLVQKTKEKHPAIEINNEYGPTENSVV 5956 Query: 2491 SFYTLDKGSEVNHARLPAGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQA 2550 + T+ + E A + G + + V IV E I VG+L L+ GY N+ Sbjct: 5957 T--TISRSIEAGQA-ITIGRPLANVQVYIVDEQHHLQPIGVVGELCIGGAGLARGYLNKP 6013 Query: 2551 GVTERVFASGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLD 2610 +T F + P +R+Y++GD + +G +EY GR D Q+K+RGYR+++ EIES + Sbjct: 6014 ELTAEKFVANPFRPGERMYKTGDLVKWRTDGTIEYIGRADEQVKVRGYRIEIGEIESAVL 6073 Query: 2611 HIPFIQQSIVTATLDHEGEQA-IAAYYVLKEPAAEKDIIRLLREQLPAYLIPRYWIELKF 2669 I Q++V A D + + AY+V + + L ++LPAY+IP Y++EL Sbjct: 6074 AYQGIDQAVVVARDDDATAGSYLCAYFVAATAVSVSGLRSHLAKELPAYMIPSYFVELDQ 6133 Query: 2670 FPMTGPNKVDRNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFF 2729 P++ KVDR ALP P S+ EYV PRN E LA +W EVLG++ IG+ D FF Sbjct: 6134 LPLSANGKVDRKALPKPQQ--SDATTREYVAPRNATEQQLAAIWQEVLGVEPIGITDQFF 6191 Query: 2730 EIGGHS----LLLMQVQNNLEKELKLTVEMGDLFKYPTISSLATFLKDKHNHNDY----- 2780 E+GGHS LL+ +V ++ EL L + +F+YPTI +A F+ K + Y Sbjct: 6192 ELGGHSLKATLLIAKVYEYMQIELPLNL----IFQYPTIEKVADFITHKRFESRYGTAIL 6247 Query: 2781 LNQSKQR 2787 LNQ R Sbjct: 6248 LNQETAR 6254 Score = 629 bits (1622), Expect = e-178, Method: Compositional matrix adjust. Identities = 384/1181 (32%), Positives = 611/1181 (51%), Gaps = 44/1181 (3%) Query: 1616 PEPVTRKSQGKRPELPVAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGDSLKAI 1675 P+P ++ G A+V A DTE KL I++ LG IGI D+FFE+ G SLKA+ Sbjct: 4061 PQPSGERTTGS------AFVAAQNDTEAKLQQIWQEVLGIPAIGIHDNFFEIGGHSLKAM 4114 Query: 1676 HVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYPTSLAQKR 1735 +VI+ + K F L L F TI +A I ++ I PV P + YP S AQKR Sbjct: 4115 NVITQVHKTFQVELPLKALFATPTIHELAAHIAESAFEQFETIQPVEPAAFYPVSFAQKR 4174 Query: 1736 IFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAENGEIVQII 1795 ++ L + YN + ++LEG ++ R ++ RHESLRTSF + NGE +Q + Sbjct: 4175 MYILHQFEGSGISYNVPSVLVLEGKLDYDRFAAAIQSLVKRHESLRTSFHSVNGEPLQRV 4234 Query: 1796 HPHVDFKLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVVDMHHIIA 1855 HP V+ + E E ++ IQPFDL APL RV L++ G ++ + +DMHHII+ Sbjct: 4235 HPDVELPVRLLEATEDQSESLIQELIQPFDLEIAPLFRVNLIKLGAERHLFFMDMHHIIS 4294 Query: 1856 DGTSVNLLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLEKLAGPLP 1915 DG S+ ++V + A LY GK L L IQYKD+A WQ S+ ++ +E +W AG +P Sbjct: 4295 DGVSLAVIVEEIASLYAGKQLSDLRIQYKDFAVWQTKLAQSDRFQKQEDFWTRTFAGEIP 4354 Query: 1916 VLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXXXXXXXXS 1975 +L LP DYPRP+ SF G + L E+++K + E T FM + + Sbjct: 4355 LLNLPHDYPRPSVQSFDGDTVALGTGHHLLEQLRKLAAETGTTLFMVLLAAYHVLLSKYA 4414 Query: 1976 GESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEVRASLLEA 2035 G+ +I++G P AGR+H DV+ +VGMFVN+L L+N F AFL++V+ + L A Sbjct: 4415 GQEEIVVGTPIAGRSHADVERIVGMFVNTLALKNTAAGSLS----FRAFLEDVKQNALHA 4470 Query: 2036 LENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLSPYPMTSK 2095 E+QD+ E +V++L +RD R L+DT+F+ + E E + D+K+SPYP+ Sbjct: 4471 FEHQDYPFEHLVEKLQVRRDLSRNPLFDTMFSL-GLAESAEGEVA---DLKVSPYPVNGH 4526 Query: 2096 TTKADLNIHLYEVPSGIYVECFYRTDLFKRETVQYIFEEYRRLIEAIPEQAGRTIGELPV 2155 K DL++ E G+ V+ Y T LF +ETV + Y +L++ I + + V Sbjct: 4527 IAKFDLSLDAMEKQDGLLVQFSYCTKLFAKETVDRLAAHYVQLLQTITADPDIELARISV 4586 Query: 2156 FRQNDIPPAGGNVSPPVRFQAFHYNDPAENLVQR-FEKQVAAYPAHTAVKYREESLNYRQ 2214 + + + F A P + Q+ FE+QV P AV + E L Y++ Sbjct: 4587 LSKAETEHMLHS------FLATKTAYPTDKTFQKLFEEQVEKTPNEIAVLFGNEQLTYQE 4640 Query: 2215 LNEQANRIARRIWELKEQESVERPVALLFGNTIEMVAALAGAIKAGIPFVPLDRSAPLQR 2274 LN +AN++AR + ++ E V +L ++ MV + +KAG FVP+D PL+R Sbjct: 4641 LNAKANQLARVLR--RKGVKPESTVGILVDRSLYMVIGMLAVLKAGGTFVPIDPDYPLER 4698 Query: 2275 LIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNTAEGLSGVSAENPSVCPDGDQT 2334 M+ D++A L+LT + S E + V+ E + P + Sbjct: 4699 QAFMLEDSEAKLLLTLQKMNSQVAFPYETFYLDTETVDQEETGNLEHVAQP------ENV 4752 Query: 2335 AFILYTSGSSGIPKGVV---QSYRNIAFYIAQFTH--SLAVNHQDRMALLTTYSHAIGIL 2389 A+I+YTSG++G PKGVV +SY N+AF H S V R+ + +++ + Sbjct: 4753 AYIIYTSGTTGKPKGVVIEHRSYANVAFAWKDEYHLDSFPV----RLLQMASFAFDVSTG 4808 Query: 2390 DILASLLNGATLHLCDLKLDASIQRLSSWLNSEGITLYHSVPSVFRFLMKNL-PGDVKLP 2448 D +LL G L +C + L + IT++ + P++ LM + ++ + Sbjct: 4809 DFARALLTGGQLVICPNGVKMDPASLYETIRRHEITIFEATPALIMPLMHYVYENELDMS 4868 Query: 2449 SLRMVLLGGEVVTRADFELYKKNCAEHCLFVNFLGCSELMV-ISFYTLDKGSEVNHARLP 2507 +++++LG + DF+ + +N G +E + S+Y + + +P Sbjct: 4869 QMKLLILGADSCPAEDFKTLLARFGQKMRIINSYGVTEACIDTSYYEETDVTAIRSGTVP 4928 Query: 2508 AGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQAGVTERVFASGPDSGAKR 2567 G + + + +V + VG+L ++ GY N+ +TE F P + +R Sbjct: 4929 IGKPLPNMTMYVVDAHLNLQPVGVVGELCIGGAGVARGYLNRPELTEEKFVPNPFAPGER 4988 Query: 2568 LYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATLDHE 2627 LYR+GD + +G +E+ GRND Q+KIRG R++L EIE+ L + I +++V A D Sbjct: 4989 LYRTGDLAKWRADGNVEFLGRNDHQVKIRGVRIELGEIETQLRKLDGITEAVVVAREDRG 5048 Query: 2628 GEQAIAAYYVLKEPAAEKDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNALPAPD 2687 E+ + AY V ++ L ++LP +IP Y++ L P+T KVDR +LPAPD Sbjct: 5049 QEKELCAYVVADHKLDTAELRANLLKELPQAMIPAYFVTLDALPLTANGKVDRRSLPAPD 5108 Query: 2688 AIPSNDLR-HEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNNLE 2746 LR EYV PR+ E LA++W +VL + +G D FF +GGHSL M+V +++ Sbjct: 5109 V---TMLRTTEYVAPRSVWEARLAQVWEQVLNVPQVGALDDFFALGGHSLRAMRVLSSMH 5165 Query: 2747 KELKLTVEMGDLFKYPTISSLATFLKDKHNHNDYLNQSKQR 2787 E ++ + + LF+ PTI LA F+++ N + + Q+ Sbjct: 5166 NEYQVDIPLRILFEKPTIQELAAFIEETAKGNVFSIEPVQK 5206 Score = 299 bits (766), Expect = 7e-79, Method: Compositional matrix adjust. Identities = 261/1075 (24%), Positives = 499/1075 (46%), Gaps = 79/1075 (7%) Query: 1727 YPTSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRA 1786 YP + Q+ + F + Y S +EG+ + E+ +++ +E LRT+F Sbjct: 11 YPLTPLQEGMLFHAVTDTGSSAYCLQMSATIEGDFHLPLFEKSLNKLVENYEVLRTAFVY 70 Query: 1787 ENGEIVQIIHPHVDFKLIRTAVKEQGIE-----------EAVERFIQPFDLARAPLIRVG 1835 +N + + V FK + V + I +A + FDL + L++ Sbjct: 71 QNMQRPR----QVVFKERKVTVPCENIAHLPSAEQDAYIQAYTKQHHAFDLTKDNLMKAA 126 Query: 1836 LLQAGEQQSILVVDMHHIIADGTSVNLLVND----FADLYMGKILPPLAIQ-YKDYAEWQ 1890 + Q E + LV HHII DG ++ +L++ +A L G+ +P A + Y +Y +W Sbjct: 127 IFQTAENKYRLVWAFHHIIVDGWTLGVLLHKLLTYYAALRKGEPIPREATKPYSEYIKWL 186 Query: 1891 QGFITSEAYRSKETYWLEKLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKK 1950 EA YW LAG P A ++ + ++++ + Sbjct: 187 DKQNKDEAL----AYWQNYLAGYDHQAAFPKKKLGTEASRYEHVEAMFTIAPEKTQQLIQ 242 Query: 1951 FSQEQQVTWFMTMXXXXXXXXXXXSGESDILIGIPQAGR--NHEDVQEMVGMFVNSLVLR 2008 + + Q T D++ G +GR + ++ MVG+F+N++ R Sbjct: 243 IANQNQATMSSVFQALWGILASTYKNADDVVFGSVVSGRPPQIQGIESMVGLFINTIPTR 302 Query: 2009 NQPXXXXERKKPFLAFLQEVRASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNY 2068 Q +++ F LQ V+ +AL + + + Y+ + I + Sbjct: 303 VQ----TNKQQTFSELLQTVQK---QALASATYDFAPL-----YEIQSTTVLKQELIDHL 350 Query: 2069 QSMKNQTETEASYLHDMKLSPYPMTS--KTTKADLNIHLYEVPSG-IYVECFYRTDLFKR 2125 + +N + +L + + + S + T DLN+ + PS +YV+ Y +++ Sbjct: 351 VTFENYPDHSMKHLEESLGFQFTVESGDEQTSYDLNVVVALAPSNELYVKLSYNAAVYES 410 Query: 2126 ETVQYIFEEYRRLIEAIPEQAGRTIGELPVFRQNDIPPAGGNVSPPVRFQAF-HYNDPA- 2183 V I R +I+ + IG P ++I G ++ + Q YND A Sbjct: 411 SFVNRIEGHLRTVIDQV-------IGN-PHVHLHEI----GIITEEEKQQLLVAYNDTAA 458 Query: 2184 -----ENLVQRFEKQVAAYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERP 2238 + + + +Q + PA AV E++L Y++L E++ ++A + E + + Sbjct: 459 EYPRDKTIFELIAEQASRTPAKAAVVCGEDTLTYQELMERSAQLANALRE--KGIASGSI 516 Query: 2239 VALLFGNTIEMVAALAGAIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSENESIAR 2298 V+++ +++E++ A+ +++G ++P+D P R+ ++++D+Q TL+LT S + R Sbjct: 517 VSIMAEHSLELIVAIMAVLRSGAAYLPIDPEYPQDRIQYLLDDSQTTLLLTQSHLQPNIR 576 Query: 2299 ELAERVHAKVTIVNTAEGLSGVSAENPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIA 2358 ++ + + EG G ++ P PD A+++YTSGS+G PKG + +++ + Sbjct: 577 FAGSVLY--LDDRSLYEG--GSTSFAPESKPD--DLAYMIYTSGSTGNPKGAMITHQGLV 630 Query: 2359 FYIAQFTHSLAVNHQDRMALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSSW 2418 YI L ++ S + + I LL+G T+H+ + +Q + Sbjct: 631 NYIWWANKVYVQGEAVDFPLYSSISFDLTVTSIFTPLLSGNTIHVY--RGADKVQVILDI 688 Query: 2419 LNSEGITLYHSVPSVFRFLMKNLPGDVKLPSLRMVLLGGE-VVTRADFELYKKNCAEHCL 2477 + + + P+ + L++++ G K S+R ++GGE + T+ ++Y + E+ Sbjct: 689 IKDNKVGIIKLTPTHLK-LIEHIDG--KASSIRRFIVGGENLPTKLAKQIYD-HFGENVQ 744 Query: 2478 FVNFLGCSELMVISFYTLDKGSEVNHARLPAGYAVDGIDVRIVGESGREAGIFEVGQLVY 2537 N G +E +V L +P G D + + ++ S + + +G++ Sbjct: 745 IFNEYGPTETVVGCMIYLYDPQTTTQESVPIGVPADNVQLYLLDASMQPVPVGSLGEMYI 804 Query: 2538 QSEYLSPGYWNQAGVTERVFASGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRG 2597 + ++ GY+N+ +T+ F P ++YR+GD + LP+G +EY GR D Q+KIRG Sbjct: 805 AGDGVAKGYFNRPELTKEKFIDNPFRPGTKMYRTGDLAKWLPDGNMEYAGRMDYQVKIRG 864 Query: 2598 YRVDLNEIESTLDHIPFIQQSIVTATLDHEGEQAIAAYYVLKEPAAEKDIIRLLREQLPA 2657 +R+++ EIE+ L +++++V D G+ + AY V + ++ L LP+ Sbjct: 865 HRIEMGEIETRLTQHEAVKEAVVIVEKDESGQNVLYAYLVSERELTVAELREFLGRTLPS 924 Query: 2658 YLIPRYWIELKFFPMTGPNKVDRNALPAP-DAIPSNDLRHEYVPPRNEMENMLARLWGEV 2716 Y+IP ++I L P+T KV+R LP P A+ + Y P+NE+E LA +W +V Sbjct: 925 YMIPSFFIRLAEIPLTANGKVERKKLPKPAGAVVTGT---AYAAPQNEIEAKLAEIWQQV 981 Query: 2717 LGIQHIGVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTISSLATFL 2771 LGI +G+ D FF++GGHSL M V + K L++ + + LF++PT++ LA FL Sbjct: 982 LGISQVGIHDDFFDLGGHSLKAMTVVFQVSKALEVELPVKALFEHPTVAELARFL 1036 >gb|AAB80956.1| fengycin synthetase FenE [Bacillus subtilis] Length = 2554 Score = 665 bits (1715), Expect = 0.0, Method: Compositional matrix adjust. Identities = 407/1167 (34%), Positives = 632/1167 (54%), Gaps = 43/1167 (3%) Query: 1618 PVTRKSQGKRPELPV--------AYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSG 1669 PVT + R LP Y TE KL ++E L P+GI D+FF+ G Sbjct: 938 PVTPSGKLDRKALPAPDGAADRETYTAPRNLTEMKLSQLWEEVLKSGPVGIHDNFFDRGG 997 Query: 1670 DSLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYPT 1729 SLKA ++S I K+F + L D F + T++ +A I + + I P + YP Sbjct: 998 HSLKATALVSRIAKEFGVQVPLKDVFAHPTVEGLASVISEGTESPYEAIKPAGKRETYPV 1057 Query: 1730 SLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAE-N 1788 S AQKR++ LQ L GYN + LEG ++ R++ VF ++I RHESLRTSF + + Sbjct: 1058 SSAQKRMYVLQQLEDGGTGYNMPAVLELEGKLDLTRMDAVFKKLIKRHESLRTSFTTDTD 1117 Query: 1789 GEIVQIIHPHVDFKLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVV 1848 GE VQ IH V F+ + + Q +EA FIQPFDL++APL R G+++ + + +L+V Sbjct: 1118 GEPVQRIHDEVPFRFHTSVLGGQTEQEAASAFIQPFDLSQAPLFRAGIVKVSDGRHLLLV 1177 Query: 1849 DMHHIIADGTSVNLLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLE 1908 DMHHII+DG SVN L+ +F +LY + LP L IQYKDYA WQ+ F E Y+++E YWL+ Sbjct: 1178 DMHHIISDGVSVNTLIREFGELYANQELPALHIQYKDYAVWQEAFKKGETYKTQEAYWLK 1237 Query: 1909 KLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXX 1968 +L G LPVL LP DY RP +F G +++ LD+ + + K ++E T +M + Sbjct: 1238 QLEGELPVLDLPADYARPPVRTFAGDQVSFTLDQELTAGLHKLARENGSTLYMVLLAAYT 1297 Query: 1969 XXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEV 2028 SG+ DI++G P AGR H+D++ ++GMFVN+L LR +P E KPF FLQEV Sbjct: 1298 ALLARLSGQEDIIVGSPIAGRPHKDLEPILGMFVNTLALRARP----EGGKPFAQFLQEV 1353 Query: 2029 RASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLS 2088 R + LEA E+QD+ E +VD+L RD R L+D +F Q+M + E+ L D+ L Sbjct: 1354 RETALEAYEHQDYPFEELVDKLGMTRDMSRNPLFDVMFVLQNM----DQESMQLKDLCLR 1409 Query: 2089 PYP-MTSKTTKADLNIHLYEVPSG-IYVECFYRTDLFKRETVQYIFEEYRRLIEAIPEQA 2146 P + + +K DL ++ YE +G + + Y TDL+++ T++ ++ AI + + Sbjct: 1410 PATNVEHQVSKFDLTLYAYEEANGSMMFQMEYSTDLYQKNTIEMWLHYLMNMLRAIIQDS 1469 Query: 2147 GRTIGELPVFRQNDIPPAGGNVSPPVRFQAFHYNDPAENLVQRFEKQVAAYPAHTAVKYR 2206 +G + V +N+ ++ R H E + + FE Q A P AV Sbjct: 1470 EAALGTIHVLDENETHFLIHELNCTKREYPRH-----ETISRLFELQAAQTPDAIAVAGD 1524 Query: 2207 EESLNYRQLNEQANRIARRIWELKEQESVERPVALLFGNTIEMVAALAGAIKAGIPFVPL 2266 E++L Y++LN +ANRIA + ++ E VALL T E+ A + G +KAG ++P+ Sbjct: 1525 EQTLTYKELNIRANRIAAVL--RRKGVGPETVVALLTTRTPEIAAGMLGILKAGGAYLPI 1582 Query: 2267 DRSAPLQRLIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNTAEGLSGVSAENPS 2326 + P R+ +M++D+ A ++L SE + R E K+ I E + G Sbjct: 1583 AKDLPADRISYMLSDSGAKILL-QSEKANNQRLDLELKCEKIVI----EEIQGQGETKNF 1637 Query: 2327 VCPDGDQT-AFILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQDRMALLTTYSHA 2385 P G + A+I+YTSGS+G PKGV+ R++ + + ++ + +DR+ L ++ Sbjct: 1638 EAPAGPHSLAYIIYTSGSTGKPKGVMIEQRSV-IRLVKNSNYIEFTPEDRLLLTSSLGFD 1696 Query: 2386 IGILDILASLLNGATLHLCDLKLDASIQRLSSWLNSEGITLYHSVPSVFRFLMKNLPGDV 2445 + +IL LLNGA LHL D + +L ++ GIT S+F L + + Sbjct: 1697 VVTFEILGPLLNGAALHLTDKETFLDSHQLKRYIEQNGITTMWLTASLFNHLTEQ--NEK 1754 Query: 2446 KLPSLRMVLLGGEVVTRADFELYKKNCAEHCLFVNFLGCSELMVISFYTLDKGSEVNHAR 2505 L +++GGE ++ + K+ C E ++ N G +E +F T ++ Sbjct: 1755 IFSRLINLIIGGEALSASHVNRIKQACPELSIW-NGYGPTE--NTTFSTCFHIEKLYEHS 1811 Query: 2506 LPAGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQAGVTERVFASGPDSGA 2565 +P G + I+ + G I VG+L + ++ GY + +T+ F P + Sbjct: 1812 IPIGRPIGNSTAFILNKWGMLQPIGAVGELCVGGDGVARGYLGRPDLTKEKFVPNPFAPG 1871 Query: 2566 KRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATLD 2625 +++YR+GD R LP+G +EY GR D Q+KIRGYRV+L EIES L HI ++++ V A Sbjct: 1872 EQMYRTGDLARWLPDGTIEYVGRVDDQVKIRGYRVELGEIESALRHIDGVKEAAVLARTG 1931 Query: 2626 HEGEQAIAAYYVLKEPAAEKDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNALPA 2685 G + + AY +KE + + L + LP Y++P Y IE+ P+T K++R ALP Sbjct: 1932 QLGTKELYAYISVKEGTDAEQVRTHLSQMLPGYMMPAYVIEMDALPLTANGKLNRKALPE 1991 Query: 2686 PDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNNL 2745 PD + YVPPRN++E LA +W EVLG Q IG++D FFE+GG S+ +QV L Sbjct: 1992 PDITS----KQTYVPPRNDLEEQLAIIWQEVLGTQRIGIEDSFFELGGDSIKALQVSARL 2047 Query: 2746 EKELKLTVEMGDLFKYPTISSLATFLK 2772 + ++ DLF++P I L+ ++ Sbjct: 2048 GR-YGWSLHASDLFRHPKIKDLSAVIR 2073 Score = 322 bits (825), Expect = 1e-85, Method: Compositional matrix adjust. Identities = 275/1072 (25%), Positives = 486/1072 (45%), Gaps = 70/1072 (6%) Query: 1727 YPTSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRA 1786 YP S Q+ + F + Y E S + G ++ R ++ + +R+E RT+F Sbjct: 11 YPLSFMQEGMLFHSLYDEQSRAYFEQASFTINGQLDLDRFQKSMDAVFDRYEIFRTTFIY 70 Query: 1787 EN-GEIVQII----HPHVDFKLIRTAVKEQGIEEAVERFIQP-----FDLARAPLIRVGL 1836 +N + Q++ HV F+ I + + E+ E E F + FDL L+R+ + Sbjct: 71 KNVAKPRQVVLKNRSCHVHFEDI-SHLNEREKEHCTEAFKEQDKKRGFDLQSDVLMRISV 129 Query: 1837 LQAGEQQSILVVDMHHIIADGTSVNLLVNDFADLYM----GKI--LPPLAIQYKDYAEWQ 1890 L+ ++ + + HHI+ DG + +++ DF +Y G++ L P+ Y Y +W Sbjct: 130 LKWAPERYVCIWSHHHILMDGWCLGIIIKDFLHIYQALGEGRLPYLQPVQ-PYGTYIKW- 187 Query: 1891 QGFITSEAYRSKETYWLEKLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKK 1950 + + YW ++L +LP + + Q ++T + + ++K Sbjct: 188 ---LMQQDREEAAAYWKKRLQHFEKASSLPKRNEQVSEGELQ--QVTFTISEKETSDLQK 242 Query: 1951 FSQEQQVTWFMTMXXXXXXXXXXXSGESDILIGIPQAGRNHE--DVQEMVGMFVNSLVLR 2008 + T + D + G +GR E DV+ +VG+F+N++ +R Sbjct: 243 IAAASGATLNTVFQALWGILLQKFNRCDDAVFGSVVSGRPSELEDVENIVGLFINTIPIR 302 Query: 2009 NQPXXXXERKKPFLAFLQEVRASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNY 2068 Q + F + ++ + EA F + I Q K++ L D I + Sbjct: 303 VQ-----SKALSFSGLVSRMQKEMTEAEAYSYFPLYDIQAQSALKQE-----LIDHIIVF 352 Query: 2069 QSMKNQTETEA---SYLHDMKLSPYPMTSKTTKADLNIHLYEVPS-GIYVECFYRTDLFK 2124 +++ Q E E + + + M +T + + +P ++V + T L++ Sbjct: 353 ENVPTQQEIEGLNQTGSFGFSVENFAMAEET---NYGCSVKVIPGRTLFVRINFHTGLYE 409 Query: 2125 RETVQYIFEEYRRLIEAIPEQAGRTIGELPVFRQNDIPPAGGNVSPPVRFQAFHYNDPAE 2184 + I + + +I A+ + ++ + + + A A Sbjct: 410 PGIIAEIKDYLQHMISAVISDPSLPVSKMTLLDHDKTQKMVAEYNTTGAVSAL-----AP 464 Query: 2185 NLVQRFEKQVAAYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVALLFG 2244 L FE+QVA P TA+++ SL Y QL+ ANR+A R+ + E V +L Sbjct: 465 TLHGLFERQVALTPDRTALRFSGGSLTYAQLDMYANRLAARL--TAHGITKESIVGVLSE 522 Query: 2245 NTIEMVAALAGAIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSENESIARELAERV 2304 + +M+ A+ +KAG +VPLD + P +RL +M+ D+ A L+LT L V Sbjct: 523 RSPDMLTAVLAVLKAGGAYVPLDPAYPEERLSYMLKDSGAALLLTQPG-------LKAPV 575 Query: 2305 HAKVTIVNTAEGLSGVSAENPSVC-PDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIAQ 2363 + T+ L+ +E S+ D D A+++YTSGS+G PKGV +R ++ Sbjct: 576 FSGKTLEVDMTALANEESECHSLHQADSDSLAYVIYTSGSTGRPKGVAVEHRQAVSFLTG 635 Query: 2364 FTHSLAVNHQDRMALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSSWLNSEG 2423 + D + + T++S + + L+GA+ +L + + + EG Sbjct: 636 MQMQFPLEEDDIIMMKTSFSFDASVWQLFWWTLSGASAYLLPSGWEKDPALMVKAIREEG 695 Query: 2424 ITLYHSVPSVFRFLMKNLPGDVKLP-SLRMVLLGGEVVTRADFELYKKNCAEHCLFVNFL 2482 +T H +P++ + +++ P SL+ V GGE + + E L V+ Sbjct: 696 VTTAHFIPAMLNSFLDQ--AEIEAPRSLKRVFAGGEPLAPHTAARFASLLPETSL-VHGY 752 Query: 2483 GCSELMV-ISFYTLDKGSEVNHARLPAGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEY 2541 G +E V +FY D + N RLP G V G + ++ + G+L Sbjct: 753 GPTEATVDAAFYACDPELDKNRLRLPIGKPVPGARLYVLDPHLAVQPVGVAGELYIAGAG 812 Query: 2542 LSPGYWNQAGVTERVFASGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVD 2601 ++ GY N+ +TE F P +R+Y++GD R LP+G +E+ GR D Q+KIRGYR++ Sbjct: 813 VARGYLNRPELTEERFLDDPFYPGERMYKTGDLARWLPDGQVEFLGRLDDQVKIRGYRIE 872 Query: 2602 LNEIESTLDHIPFIQQSIVTATLDHEGEQAIAAYYVLKEPAAEKDIIRLLREQLPAYLIP 2661 EIE+ L I ++++ VT + GE + AY E ++ + L LP Y+IP Sbjct: 873 PGEIEAALRSIEGVREAAVTVRTE-SGEAELCAY---AEGLGRNEVRKQLETLLPGYMIP 928 Query: 2662 RYWIELKFFPMTGPNKVDRNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQH 2721 + IE++ +P+T K+DR ALPAPD R Y PRN E L++LW EVL Sbjct: 929 AHIIEMEQWPVTPSGKLDRKALPAPDGAAD---RETYTAPRNLTEMKLSQLWEEVLKSGP 985 Query: 2722 IGVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTISSLATFLKD 2773 +G+ D FF+ GGHSL + + + KE + V + D+F +PT+ LA+ + + Sbjct: 986 VGIHDNFFDRGGHSLKATALVSRIAKEFGVQVPLKDVFAHPTVEGLASVISE 1037 Score = 111 bits (277), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 88/327 (26%), Positives = 147/327 (44%), Gaps = 41/327 (12%) Query: 1618 PVTRKSQGKRPELP-------VAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGD 1670 P+T + R LP YVP D E++L I++ LG Q IGIED FFEL GD Sbjct: 1977 PLTANGKLNRKALPEPDITSKQTYVPPRNDLEEQLAIIWQEVLGTQRIGIEDSFFELGGD 2036 Query: 1671 SLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQ----IAPVNPKSH 1726 S+KA+ V + + + + +L +D F++ IK ++ IR R ++ P P H Sbjct: 2037 SIKALQVSARLGR-YGWSLHASDLFRHPKIKDLSAVIRKTERVIDQGSVQGAVPWTPIQH 2095 Query: 1727 YPTSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRA 1786 + FL + + +N+S + ++ + ++ H++LR +R Sbjct: 2096 W----------FLSQDIKERHHFNQSVMLFSPDCLSENALRASLKKLAEHHDALRMIYRE 2145 Query: 1787 ENGEIVQI---IHPHVDFKLIRTAVKEQG------IEEAVERFIQPFDLARAPLIRVGLL 1837 ++G+ +QI IH + L + + + G I+E V Q +L + PL+ Sbjct: 2146 DSGQQMQINQDIHESKLYSLRISDLSDSGMDWETSIKEEVANLQQSINLQQGPLLHAAWF 2205 Query: 1838 QAGEQQSILVVDMHHIIADGTSVNLLVNDFADLYMGKI------LPPLAIQYKDYAEWQQ 1891 + L + +HH++ DG S +L+ D + Y LPP Y++YA Q Sbjct: 2206 KT-LSGDYLFLTIHHLVVDGVSWRILLEDLSAAYHQAASGQAIQLPPKTDSYQEYARRVQ 2264 Query: 1892 GFITSEAYRSKETYWL---EKLAGPLP 1915 + S +ETYW E+ A LP Sbjct: 2265 DYAQSSKLIREETYWRSVEEEKAAELP 2291 >ref|NP_389714.1| peptide synthetase [Bacillus subtilis] sp|P39847|PPS3_BACSU Peptide synthetase 3 pir||C69681 peptide synthetase ppsC - Bacillus subtilis emb|CAA84362.1| peptide-synthetase ORF3 [Bacillus subtilis] emb|CAB13715.1| plipastatin synthetase [Bacillus subtilis subsp. subtilis str. 168] Length = 2555 Score = 661 bits (1706), Expect = 0.0, Method: Compositional matrix adjust. Identities = 399/1168 (34%), Positives = 641/1168 (54%), Gaps = 47/1168 (4%) Query: 1618 PVTRKSQGKRPELPV--------AYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSG 1669 PVT + R LP Y TE KL ++E+ L P+GI D+FF+ G Sbjct: 941 PVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKNGPVGIHDNFFDRGG 1000 Query: 1670 DSLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYPT 1729 SLKA ++S I K+FD + L D F + T++ +A IR + + I P + YP Sbjct: 1001 HSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLATVIREGTDSPYEAIKPAEKQETYPV 1060 Query: 1730 SLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAE-N 1788 S AQKRI+ LQ L GYN + LEG +N R++ F ++I RHESLRT+F + Sbjct: 1061 SSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNLERMDRAFKELIKRHESLRTAFEQDAG 1120 Query: 1789 GEIVQIIHPHVDFKLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVV 1848 G+ VQ IH V F L T + + EEA FI+PFDL++APL R +++ +++ +L+V Sbjct: 1121 GDPVQRIHDEVPFTLQTTVLGARTEEEAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLV 1180 Query: 1849 DMHHIIADGTSVNLLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLE 1908 DMHHII+DG SVN+L+ +F +LY + LP L IQYKDYA WQ+GF T +AY+++ YWL+ Sbjct: 1181 DMHHIISDGVSVNILIREFGELYNNRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLK 1240 Query: 1909 KLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXX 1968 +L G LPVL LP D+ RP SF G +++ LD+ + + K ++E T +M + Sbjct: 1241 QLEGELPVLDLPADHARPPMRSFAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYT 1300 Query: 1969 XXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEV 2028 SG+ DI++G P AGR H+D++ ++GMFVN+L LR +P E KPF+ +LQEV Sbjct: 1301 AFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFVNTLALRTRP----EGGKPFVQYLQEV 1356 Query: 2029 RASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLS 2088 R + +EA E+QD+ E +VD+L+ RD R L+D +F Q+M + E+ L ++ L Sbjct: 1357 RETAMEAFEHQDYPFEELVDKLELTRDMSRNPLFDVMFVLQNM----DQESLELDELCLK 1412 Query: 2089 PYPMTS-KTTKADLNIHLYEVPSGIYV-ECFYRTDLFKRETVQYIFEEYRRLIEAIPEQA 2146 P +T+K DL ++ E P G+ + + TDL+K++T++ + + ++ +I + Sbjct: 1413 PAANNGHQTSKFDLTLYAQEQPRGLLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDN 1472 Query: 2147 GRTIGELPVFRQNDIPPAGGNVSPPVRFQAFHYNDPAENLVQRFEKQVAAYPAHTAVKYR 2206 +G + + +++ A + R + + + E + + FE Q P A+ Sbjct: 1473 KAALGTINILNEDE---AHYLIHELNRTKIDYPRN--ETISRLFEMQAEQTPNAVAIVSD 1527 Query: 2207 EESLNYRQLNEQANRIARRIWELK--EQESVERPVALLFGNTIEMVAALAGAIKAGIPFV 2264 + Y LN AN+IA + ++K +SV VALL G T E++A + G +KAG ++ Sbjct: 1528 TQVFTYEDLNSWANQIA-SVLQIKGVGPDSV---VALLTGRTPELIAGMLGILKAGGAYL 1583 Query: 2265 PLDRSAPLQRLIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNTAEGLSGVSAEN 2324 P+D + P++R+ +M++D++A L+L + E R L + + I+ + Sbjct: 1584 PIDSNLPVERIAYMLSDSRAALLLQSEKTEK--RLLG--IECEQIIIEDIQKQGEAKNVE 1639 Query: 2325 PSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQDRMALLTTYSH 2384 S P A+I+YTSGS+G PKGV+ R++ + + ++ + +DR+ + ++ Sbjct: 1640 SSAGPHS--LAYIIYTSGSTGKPKGVMIEQRSV-IRLVKNSNYITFTPEDRLLMTSSIGF 1696 Query: 2385 AIGILDILASLLNGATLHLCDLKLDASIQRLSSWLNSEGITLYHSVPSVFRFLMKNLPGD 2444 +G +I LLNGA LHL D + +L ++ +GIT S+F L + + Sbjct: 1697 DVGSFEIFGPLLNGAALHLSDQQTFLDSHQLKRYIEHQGITTIWLTSSLFNHLTEQ--NE 1754 Query: 2445 VKLPSLRMVLLGGEVVTRADFELYKKNCAEHCLFVNFLGCSELMVISFYTLDKGSEVNHA 2504 L+ +++GGE ++ + + C E ++ N G +E +F T + Sbjct: 1755 QTFSQLKHLIIGGEALSPSHVNRIRNVCPEVSIW-NGYGPTE--NTTFSTCLHIQKTYEL 1811 Query: 2505 RLPAGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQAGVTERVFASGPDSG 2564 +P G V I+ + G + VG+L + ++ GY + +T+ F P + Sbjct: 1812 SIPIGRPVGNSTAFILNQWGVLQPVGAVGELCVGGDGVARGYLGRPDLTKEKFVPHPFAP 1871 Query: 2565 AKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATL 2624 RLYR+GD R L +G +EY GR D Q+K+RGYRV+L EIE+ L I ++++ V A Sbjct: 1872 GDRLYRTGDLARWLSDGTIEYVGRIDDQVKVRGYRVELGEIETALRQIDGVKEAAVLART 1931 Query: 2625 DHEGEQAIAAYYVLKEPAAEKDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNALP 2684 G + + Y +K + + LL LP Y+IP Y IE++ P+T K++R ALP Sbjct: 1932 AQTGSKELFGYISVKAGTNAEQVRSLLARSLPNYMIPAYIIEMETLPLTSNGKLNRKALP 1991 Query: 2685 APDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNN 2744 PD + Y+PPRNE+E LA +W EVLGIQ IG++D FFE+GG S+ +QV Sbjct: 1992 EPDVAS----KQTYIPPRNELEEQLALIWQEVLGIQRIGIEDSFFELGGDSIKALQVSAR 2047 Query: 2745 LEKELKLTVEMGDLFKYPTISSLATFLK 2772 L + L++++ DLF++P I L+ F++ Sbjct: 2048 LGR-YGLSLQVSDLFRHPKIKDLSPFIR 2074 Score = 303 bits (777), Expect = 4e-80, Method: Compositional matrix adjust. Identities = 276/1079 (25%), Positives = 489/1079 (45%), Gaps = 81/1079 (7%) Query: 1727 YPTSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRA 1786 YP S Q+ + F + Y E S + G ++ R ++ + +R++ RT+F Sbjct: 11 YPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQLDLERFQKSMDAVFDRYDIFRTAFIY 70 Query: 1787 EN-GEIVQII----HPHVDFKLIRTAVKEQGIEEAVERFIQP-----FDLARAPLIRVGL 1836 +N + Q++ H + + I + + E+ E E F + FDL L+R+ + Sbjct: 71 KNVAKPRQVVLKQRHCPIHIEDI-SHLNERDKEHCTEAFKEQDKSKGFDLQTDVLMRISI 129 Query: 1837 LQAGEQQSILVVDMHHIIADGTSVNLLVNDFADLY--MGK----ILPPLAIQYKDYAEW- 1889 L+ + + HHI+ DG + +++ DF +Y +GK LPP+ Y Y +W Sbjct: 130 LKWAPDHYVCIWSHHHILMDGWCLGIVIKDFLHIYQALGKGQLPDLPPVQ-PYGTYIKWL 188 Query: 1890 -QQGFITSEAYRSKETYWLEKLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERI 1948 QQ + Y K EK + PLP T D L +IT + + + Sbjct: 189 MQQDREEAAEYWKKRLQHFEK-STPLPKRT---DQIPNGTLQ----QITFAIPEKETAEL 240 Query: 1949 KKFSQEQQVTWFMTMXXXXXXXXXXXSGESDILIGIPQAGRNHE--DVQEMVGMFVNSLV 2006 +K + T + SD + G +GR E DV+ MVG+F+N++ Sbjct: 241 QKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGSVISGRPSELKDVENMVGLFINTIP 300 Query: 2007 LRNQPXXXXERKKPFLAFLQEVRASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIF 2066 +R Q F ++ ++ + EA F + I Q K++ L D I Sbjct: 301 IRAQSDSLS-----FSDLVRRMQKDMNEAEAYSYFPLYDIQAQSALKQE-----LIDHII 350 Query: 2067 NYQSMKNQTETEA---SYLHDMKLSPYPMTSKTTKADLNIHLYEVPS-GIYVECFYRTDL 2122 +++ Q E E + D + + M T + + + +P +YV ++T Sbjct: 351 VFENTPTQQEIEELNQAGSFDFSVKDFEMEEVT---NYSCSVKVIPGRTLYVRIHFQTSA 407 Query: 2123 FKRETVQYIFEEYRRLIEAIPEQAGRTIGELPVFRQNDIPPAGGNVSPPVRFQAFHYNDP 2182 ++ + I + ++ + + ++ + ++ + V + Sbjct: 408 YQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIVSQNNRTVSV-----SPE 462 Query: 2183 AENLVQRFEKQVAAYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVALL 2242 A L FE+Q A P A+++ SL Y +L+ A+R+A + + E V +L Sbjct: 463 APTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHL--AARGVTNESIVGVL 520 Query: 2243 FGNTIEMVAALAGAIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSENESIARELAE 2302 + +M+ A+ +KAG ++PLD + P +RL +M+ D+ A+L+LT S E Sbjct: 521 SERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQP-GCSAPNFSGE 579 Query: 2303 RVHAKVTIVNTAEGLSGVSAENPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIA 2362 + +T + E VSA DG A+++YTSGS+G PKGV +R ++ Sbjct: 580 TLEVDMTSLECEEVKRHVSAS----VSDGS-LAYVIYTSGSTGQPKGVAVEHRQAVSFLT 634 Query: 2363 QFTHSLAVNHQDRMALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSSWLNSE 2422 H ++ D + + T++S + + L+GA+ +L + + ++ E Sbjct: 635 GMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEKDSALIVQAIHQE 694 Query: 2423 GITLYHSVPSVFRFLMKNLPGD--VKLPSLRMVLLGGEVV---TRADFELYKKNCAEHCL 2477 +T H +P++ + + SL+ V GGE + T A F + Sbjct: 695 NVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARF----ASVLPQVS 750 Query: 2478 FVNFLGCSELMV-ISFYTLDKGSEVNHARLPAGYAVDGIDVRIVGE--SGREAGIFEVGQ 2534 ++ G +E V +FY LD + + R+P G V G + ++ + + +G+ G+ Sbjct: 751 LIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGV--AGE 808 Query: 2535 LVYQSEYLSPGYWNQAGVTERVFASGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQLK 2594 L ++ GY N+ +TE F P +R+Y++GD R LP+G +E+ GR D Q+K Sbjct: 809 LYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGNVEFLGRTDDQVK 868 Query: 2595 IRGYRVDLNEIESTLDHIPFIQQSIVTATLDHEGEQAIAAYYVLKEPAAEKDIIRLLREQ 2654 IRGYR++ EIE+ L I ++++ VT D GE + AY E ++ L+ Sbjct: 869 IRGYRIEPGEIEAALRSIEGVREAAVTVRTD-SGEPELCAYV---EGLQRNEVRAQLQRL 924 Query: 2655 LPAYLIPRYWIELKFFPMTGPNKVDRNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWG 2714 LP Y++P Y IE++ +P+T K+DRNALPAP + Y PRN E L++LW Sbjct: 925 LPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAE---TYTAPRNVTEMKLSQLWE 981 Query: 2715 EVLGIQHIGVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTISSLATFLKD 2773 +VL +G+ D FF+ GGHSL + + + KE + V + D+F +PT+ LAT +++ Sbjct: 982 DVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLATVIRE 1040 Score = 110 bits (276), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 91/343 (26%), Positives = 159/343 (46%), Gaps = 38/343 (11%) Query: 1618 PVTRKSQGKRPELP-------VAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGD 1670 P+T + R LP Y+P + E++L I++ LG Q IGIED FFEL GD Sbjct: 1978 PLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIWQEVLGIQRIGIEDSFFELGGD 2037 Query: 1671 SLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYPTS 1730 S+KA+ V + + + + +L ++D F++ IK ++ FIR + R E+ P+ + P + Sbjct: 2038 SIKALQVSARLGR-YGLSLQVSDLFRHPKIKDLSPFIRKSERIIEQ--GPI--QGDVPWT 2092 Query: 1731 LAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAENGE 1790 Q+ +F + + +N+S + G ++ + ++ H++LR +R ++ Sbjct: 2093 PVQQ--WFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKKLAEHHDALRMVYRNDDRR 2150 Query: 1791 IVQI---IHPHVDFKLIRTAVK------EQGIEEAVERFIQPFDLARAPLIRVGLLQAGE 1841 +QI IH + L + + E I++ V Q +L PL+ L + Sbjct: 2151 WIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQQSINLQEGPLLHAALFKT-L 2209 Query: 1842 QQSILVVDMHHIIADGTSVNLLVNDFADLYMGKI------LPPLAIQYKDYAEWQQGFIT 1895 L + +HH++ DG S +L+ D + Y LPP Y++YA Q + Sbjct: 2210 TGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTIQLPPKTDSYQEYARRIQEYAQ 2269 Query: 1896 SEAYRSKETYWL---EKLAGPLPVLTLP----TDYPRPAALSF 1931 S +E YW E+ A LP +P D+ + +LSF Sbjct: 2270 SSKLIREEAYWRSVEEQQAAELP-YEIPHHVNIDFSKRDSLSF 2311 >sp|O30408|TYCB_BREPA Tyrocidine synthetase II [Includes: ATP-dependent proline adenylase (ProA) (Proline activase); ATP-dependent phenylalanine adenylase (PheA) (Phenylalanine activase); ATP-dependent D-phenylalanine adenylase (D-PheA) (D-phenylalanine activase); Phenylalanine racemase [ATP-hydrolyzing] ] pir||T31075 tyrocidine synthetase 2 - Brevibacillus brevis gb|AAC45929.1| tyrocidine synthetase 2 [Brevibacillus brevis] Length = 3587 Score = 656 bits (1693), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/1151 (32%), Positives = 620/1151 (53%), Gaps = 41/1151 (3%) Query: 1622 KSQGKRPELPVAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGDSLKAIHVISSI 1681 K +GK P AYV T+ E KL AI+EN LG +G+ D FFEL G SLKA+ V++ + Sbjct: 1994 KPEGK-PATGAAYVAPATEVEAKLVAIWENALGISGVGVLDHFFELGGHSLKAMTVVAQV 2052 Query: 1682 RKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYPTSLAQKRIFFLQG 1741 ++F +L L FF TI+ +AR I ++ +A I P P+++YP S AQ+R++ L Sbjct: 2053 HREFQIDLLLKQFFAAPTIRDLARLIEHSEQAAGAAIQPAEPQAYYPVSSAQQRMYLLHQ 2112 Query: 1742 LMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAENGEIVQIIHPHVDF 1801 L + YN ++LEG ++ ++ +++RH+ LRTSF E+VQ IH V Sbjct: 2113 LEGAGISYNTPGIIMLEGKLDREQLANALQALVDRHDILRTSFEMVGDELVQKIHDRVAV 2172 Query: 1802 KLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVVDMHHIIADGTSVN 1861 + +EQ I++ F++PFDL+ PL+R+ L++ +++ +L+ DMHHI AD S+ Sbjct: 2173 NMEYVTAEEQQIDDLFHAFVRPFDLSVPPLLRMSLVKLADERHLLLYDMHHIAADAASIT 2232 Query: 1862 LLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLEKLAGPLPVLTLPT 1921 +L ++ A+LY G+ LP + IQYKD+A WQ+ S+A++ +E YWL AG + + +PT Sbjct: 2233 ILFDELAELYQGRELPEMRIQYKDFAVWQKALHESDAFKQQEAYWLSTFAGNITAVDVPT 2292 Query: 1922 DYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXXXXXXXXSGESDIL 1981 D+PRPA SF GG++TL +D+ + + + T FM + +G+ DI+ Sbjct: 2293 DFPRPAVKSFAGGQVTLSMDQELLSALHELAAHTNTTLFMVLLAAYNVLLAKYAGQDDII 2352 Query: 1982 IGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEVRASLLEALENQDF 2041 +G P +GR+ ++ +VGMFV++L +RN+P +K F FLQEV+ + L+A ++QD+ Sbjct: 2353 VGTPISGRSRAELAPVVGMFVHTLAIRNKPTA----EKTFKQFLQEVKQNALDAFDHQDY 2408 Query: 2042 QIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLSPYPMTS--KTTKA 2099 E +V++L RDPGR L+DT+F Q+ E A L + PY S K Sbjct: 2409 PFESLVEKLGIPRDPGRNPLFDTMFILQN----DELHAKTLDQLVYRPYESDSALDVAKF 2464 Query: 2100 DLNIHLYEVPSGIYVECFYRTDLFKRETVQYIFEEYRRLIEAIPEQAGRTIGELPVFRQN 2159 DL+ HL E + +++ Y T LFK++TV+ + + +++ A+ + E+ + Sbjct: 2465 DLSFHLTERETDLFLRLEYCTKLFKQQTVERMAHHFLQILRAVTANPENELQEIEMLT-- 2522 Query: 2160 DIPPAGGNVSPPVRFQAFHYNDPAENLVQR-FEKQVAAYPAHTAVKYREESLNYRQLNEQ 2218 A V F H A+ +Q+ FE+ P HTA+ + E+ +++R+LNE+ Sbjct: 2523 ----AAEKQMLLVAFNDTHREYRADQTIQQLFEELAEKMPEHTALVFEEKRMSFRELNER 2578 Query: 2219 ANRIARRIWELKEQESVERPVALLFGNTIEMVAALAGAIKAGIPFVPLDRSAPLQRLIHM 2278 AN++A + E + + VALL + EMV A +KAG F+P+D P +R+ +M Sbjct: 2579 ANQLAAVLRE--KGVGPAQIVALLVERSAEMVIATLATLKAGGAFLPVDPDYPEERIRYM 2636 Query: 2279 VNDAQATLILTDSENESIARELAERVHAKVTIVNTAE-GLSGVSAENPSVCPDGDQTAFI 2337 + D+QA L++T + L +V ++ +V+ + G +N A+I Sbjct: 2637 LEDSQAKLVVTHA-------HLLHKVSSQSEVVDVDDPGSYATQTDNLPCANTPSDLAYI 2689 Query: 2338 LYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQDRMALLTTYSHAIGILDILASLLN 2397 +YTSG++G PKGV+ ++ +A A F H L V QDR + S + D+ LL+ Sbjct: 2690 IYTSGTTGKPKGVMLEHKGVANLQAVFAHHLGVTPQDRAGHFASISFDASVWDMFGPLLS 2749 Query: 2398 GATLHLCDLKLDASIQRLSSWLNSEGITLYHSVPSVFRFLMKNLPGDVKLPSLRMVLLGG 2457 GATL++ + QR + ++ IT P+ +L ++PSLR ++ G Sbjct: 2750 GATLYVLSRDVINDFQRFAEYVRDNAITFLTLPPTYAIYLEPE-----QVPSLRTLITAG 2804 Query: 2458 EVVTRADFELYKKNCAEHCLFVNFLGCSELMVISFYTLDKGSEVNHARLPAGYAVDGIDV 2517 + A + +K E +VN G +E V + K E + G + + Sbjct: 2805 SASSVALVDKWK----EKVTYVNGYGPTESTVCATLWKAKPDEPVET-ITIGKPIQNTKL 2859 Query: 2518 RIVGESGREAGIFEVGQLVYQSEYLSPGYWNQAGVTERVFASGPDSGAKRLYRSGDYGRL 2577 IV + + ++G+L L+ GYWN+ +T F P ++YR+GD R Sbjct: 2860 YIVDDQLQLKAPGQMGELCISGLSLARGYWNRPELTAEKFVDNPFVPGTKMYRTGDLARW 2919 Query: 2578 LPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATLDHEGEQAIAAYYV 2637 LP+G +EY GR D Q+KIRG+RV+L E+ES L ++++ D G+ + AYYV Sbjct: 2920 LPDGTIEYLGRIDHQVKIRGHRVELGEVESVLLRYDTVKEAAAITHEDDRGQAYLCAYYV 2979 Query: 2638 LKEPAAEKDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNALPAPDAIPSNDLRHE 2697 + A + + +LP Y++P ++I+L+ P+T +K+DR ALP P+ + + Sbjct: 2980 AEGEATPAQLRAYMENELPNYMVPAFFIQLEKMPLTPNDKIDRKALPKPNQ--EENRTEQ 3037 Query: 2698 YVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGD 2757 Y P+ E+E +LA +W +VLGI+ +G D FFE+GG S+ +QV L T+ M + Sbjct: 3038 YAAPQTELEQLLAGIWADVLGIKQVGTQDNFFELGGDSIKAIQVSTRLNAS-GWTLAMKE 3096 Query: 2758 LFKYPTISSLA 2768 LF+YPTI A Sbjct: 3097 LFQYPTIEEAA 3107 Score = 626 bits (1614), Expect = e-177, Method: Compositional matrix adjust. Identities = 388/1177 (32%), Positives = 626/1177 (53%), Gaps = 64/1177 (5%) Query: 1618 PVTRKSQGKRPELP---------VAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELS 1668 PVT + R LP YV T+ E+KL AI+E LG PIGI+D FF L Sbjct: 945 PVTPNGKTDRRALPKPEGSAKTKADYVAPTTELEQKLVAIWEQILGVSPIGIQDHFFTLG 1004 Query: 1669 GDSLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYP 1728 G SLKAI +IS I+K+ ++ L F+ TI+++A ++ + I P+++YP Sbjct: 1005 GHSLKAIQLISRIQKECQADVPLRVLFEQPTIQALAAYVEGGEESAYLAIPQAEPQAYYP 1064 Query: 1729 TSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAEN 1788 S AQKR+ L L P + YN +++LEG ++ R+E + ++ RHESLRTSF N Sbjct: 1065 VSSAQKRMLILNQLDPHSTVYNLPVAMILEGTLDKARLEHAISNLVARHESLRTSFHTIN 1124 Query: 1789 GEIVQIIHPHVDFKLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVV 1848 GE V IH ++ E+ + E + F+QPFDL APL RVGL++ E + +L++ Sbjct: 1125 GEPVSRIHEQGHLPIVYLETAEEQVNEVILGFMQPFDLVTAPLCRVGLVKLAENRHVLII 1184 Query: 1849 DMHHIIADGTSVNLLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLE 1908 DMHHII+DG S L++NDF+ LY K LP I YKD+A W++ + + Y+ +E YWL+ Sbjct: 1185 DMHHIISDGVSSQLILNDFSRLYQNKALPEQRIHYKDFAVWEKAWTQTTDYQKQEKYWLD 1244 Query: 1909 KLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXX 1968 + AG +PVL LP DYPRPA SF+G R ++ E ++ +Q+ T +M + Sbjct: 1245 RFAGEIPVLNLPMDYPRPAVQSFEGERYLFRTEKQLLESLQDVAQKTGTTLYMVLLAAYH 1304 Query: 1969 XXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEV 2028 SG+ D++IG AGR H D + M GMFVN+L +RNQ K F FL EV Sbjct: 1305 VLLSKYSGQDDVMIGTVTAGRVHPDTESMTGMFVNTLAMRNQSAPT----KTFRQFLLEV 1360 Query: 2029 RASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLS 2088 + + L A E+ + E +V++L +R+ R L+DT+F Q+M + + L + ++ Sbjct: 1361 KDNTLAAFEHGQYPFEELVEKLAIQRNRSRNPLFDTLFILQNM----DADLIELDGLTVT 1416 Query: 2089 PYPMTSKTTKADLNIHLYEVPSGIYVECF-YRTDLFKRETVQYIFEEYRRLIEAIPEQAG 2147 PY + K DL++ E +G+ CF + T LF RET++ + Y ++++A+ Sbjct: 1417 PYVPEGEVAKFDLSLEASENQAGLSF-CFEFCTKLFARETIERMSLHYLQILQAVSANTE 1475 Query: 2148 RTIGELPVFRQNDIPPAGGNVSPPVRFQAFHYND-----PAEN-LVQRFEKQVAAYPAHT 2201 + + ++ + ++ + H+ND PAE+ L Q FE Q P T Sbjct: 1476 QELAQIEMLTAHE-----------KQELLVHFNDTAALYPAESTLSQLFEDQAQKTPEQT 1524 Query: 2202 AVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVALLFGNTIEMVAALAGAIKAGI 2261 AV + ++ L YR+LNE+AN++A + Q E+ V ++ ++EM + +KAG Sbjct: 1525 AVVFGDKRLTYRELNERANQLAHTLRAKGVQ--AEQSVGIMAQRSLEMAIGIIAILKAGG 1582 Query: 2262 PFVPLDRSAPLQRLIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNT-AEGLSGV 2320 +VP+D P +R+ +M+ D + L+LT ++LAE++ A V + EG Sbjct: 1583 AYVPIDPDYPNERIAYMLEDCR-RLVLTQ-------QQLAEKMTANVECLYLDEEGSYSP 1634 Query: 2321 SAENPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQDRMALLT 2380 EN A+I+YTSG++G PKGV+ +R I + A++ +D L Sbjct: 1635 QTENIEPIHTAADLAYIIYTSGTTGRPKGVMVEHRGIVNSVTWNRDEFALSVRDSGTLSL 1694 Query: 2381 TYSHAIGILDILASLLNGATLHLC---DLKLDASIQRL-SSWLNSEGITLYHSVPSVFRF 2436 +++ L +++G+T+ L + K +++ L ++W S + VPS+F+ Sbjct: 1695 SFAFDAFALTFFTLIVSGSTVVLMPDHEAKDPIALRNLIAAWECSYVVF----VPSMFQA 1750 Query: 2437 LMK-NLPGDVKLPSLRMVLLGGEVVTRADFELYKKNCAEHCLFVNFLGCSELMVISFYTL 2495 +++ + P D++ S++ V+LGGE ++ +L K + + +N G +E V++ Y Sbjct: 1751 ILECSTPADIR--SIQAVMLGGEKLSPKLVQLCKAMHPQMSV-MNAYGPTESSVMATYLR 1807 Query: 2496 DKGSEVNHARLPAGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQAGVTER 2555 D + + G + + IV + + + VG++ L+ GYW + +T Sbjct: 1808 DTQPD---QPITIGRPIANTAIYIVDQHHQLLPVGVVGEICIGGHGLARGYWKKPELTAE 1864 Query: 2556 VFASGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFI 2615 F + P +R+Y++GD GR L +G +++ GR D Q+K+RGYR+++ EIE+ L Sbjct: 1865 KFVANPAVPGERMYKTGDLGRWLHDGTIDFIGRVDDQIKVRGYRIEVGEIEAVLLAYDQT 1924 Query: 2616 QQSIVTATLDHEGEQAIAAYYVLKEPAAEKDIIRLLREQLPAYLIPRYWIELKFFPMTGP 2675 ++IV A D G+ +AAY K E ++ L +LPAY++P Y I+L FP+T Sbjct: 1925 NEAIVVAYQDDRGDSYLAAYVTGKTAIEESELRAHLLRELPAYMVPTYLIQLDAFPLTPN 1984 Query: 2676 NKVDRNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHS 2735 KVDR ALP P+ P+ YV P E+E L +W LGI +GV D FFE+GGHS Sbjct: 1985 GKVDRKALPKPEGKPATGA--AYVAPATEVEAKLVAIWENALGISGVGVLDHFFELGGHS 2042 Query: 2736 LLLMQVQNNLEKELKLTVEMGDLFKYPTISSLATFLK 2772 L M V + +E ++ + + F PTI LA ++ Sbjct: 2043 LKAMTVVAQVHREFQIDLLLKQFFAAPTIRDLARLIE 2079 Score = 321 bits (823), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 269/1066 (25%), Positives = 497/1066 (46%), Gaps = 108/1066 (10%) Query: 1754 SVLLEGNINAGRIEEVFAQIINRHESLRTSFRAEN-GEIVQIIHPHVDFKLIRTAVKEQG 1812 S+ L+G+++ G + ++ R++ RT F E + +Q++ + + Sbjct: 40 SISLQGDLDVGLFTDSLHVLVERYDVFRTLFLYEKLKQPLQVVLKQRPIPIEFYDLSACD 99 Query: 1813 IEEAVERFIQ--------PFDLARAPLIRVGLLQAGEQQSILVVDMHHIIADGTSVNLLV 1864 E R+ Q F LA+ PL+RV L Q + ++ HHI+ DG +++ Sbjct: 100 ESEKQLRYTQYKRADQERTFHLAKDPLMRVALFQMSQHDYQVIWSFHHILMDGWCFSIIF 159 Query: 1865 NDFADLYM------GKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLEKLAGPLPVLT 1918 +D +Y+ L P+ Y + W + + ++ YW + L T Sbjct: 160 DDLLAIYLSLQNKTALSLEPVQ-PYSRFINW----LEKQNKQAALNYWSDYLEAYEQKTT 214 Query: 1919 LPTDYPRPAALS--FQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXXXXXXXXSG 1976 LP + AA + FQ + L+R ++++ + + QVT + + Sbjct: 215 LPK---KEAAFAKAFQPTQYRFSLNRTLTKQLGTIASQNQVTLSTVIQTIWGVLLQKYNA 271 Query: 1977 ESDILIGIPQAGRNHE--DVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEVRASLLE 2034 D+L G +GR + + +MVG+F+N++ R Q A + + LL+ Sbjct: 272 AHDVLFGSVVSGRPTDIVGIDKMVGLFINTIPFRVQ------------AKAGQTFSELLQ 319 Query: 2035 ALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLSPYPMTS 2094 A+ + Q + Y+ P LYD QS+ Q + H + + YP+ Sbjct: 320 AVHKRTLQSQ------PYEHVP----LYD--IQTQSVLKQELID----HLLVIENYPLVE 363 Query: 2095 KTTKADLN---------IHLYEVPSGIYV--------ECFYRTD----LFKRETVQYIFE 2133 K LN + ++E P+ + E +R D LF + VQ + Sbjct: 364 ALQKKALNQQIGFTITAVEMFE-PTNYDLTVMVMPKEELAFRFDYNAALFDEQVVQKLAG 422 Query: 2134 EYRRLIEAIPEQAGRTIGELPVFRQNDIPPAGGNVSPPVRFQAFHYNDPAENLVQRFEKQ 2193 +++ + + +G + ++P+ + + + + PA + + F +Q Sbjct: 423 HLQQIADCVANNSGVELCQIPLLTEAETSQLLAKRTETAA------DYPAATMHELFSRQ 476 Query: 2194 VAAYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVALLFGNTIEMVAAL 2253 P AV + ++ L YR+L+E++N++AR + K+ V L +++M+ + Sbjct: 477 AEKTPEQVAVVFADQHLTYRELDEKSNQLARFLR--KKGIGTGSLVGTLLDRSLDMIVGI 534 Query: 2254 AGAIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNT 2313 G +KAG FVP+D P +R+ +M+ ++ L++T + L +V ++ Sbjct: 535 LGVLKAGGAFVPIDPELPAERIAYMLTHSRVPLVVTQNH-------LRAKVTTPTETIDI 587 Query: 2314 AEGLSGVSAENPSVCPDGDQTAF-ILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNH 2372 + G + P + F I+YTSG++G PKGV+ +RN+A + + Sbjct: 588 NTAVIGEESRAPIESLNQPHDLFYIIYTSGTTGQPKGVMLEHRNMANLMHFTFDQTNIAF 647 Query: 2373 QDRMALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSSWLNSEGITLYHSVPS 2432 +++ TT S + +I ++LL+G L+L +L +++L +++ + I++ S Sbjct: 648 HEKVLQYTTCSFDVCYQEIFSTLLSGGQLYLITNELRRHVEKLFAFIQEKQISILSLPVS 707 Query: 2433 VFRFLMKNLPGDVKLP-SLRMVLLGGE--VVTRADFELYKKNCAEHCLFV-NFLGCSELM 2488 +F+ P ++ ++ GE VVT EL +K +H +F+ N G SE Sbjct: 708 FLKFIFNEQDYAQSFPRCVKHIITAGEQLVVTH---EL-QKYLRQHRVFLHNHYGPSETH 763 Query: 2489 VISFYTLDKGSEVNHARLPAGYAVDGIDVRIVGE--SGREAGIFEVGQLVYQSEYLSPGY 2546 V++ T+D G + P G + + I+ E + GI VG+L + GY Sbjct: 764 VVTTCTMDPGQAIPELP-PIGKPISNTGIYILDEGLQLKPEGI--VGELYISGANVGRGY 820 Query: 2547 WNQAGVTERVFASGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIE 2606 +Q +T F P +R+YR+GD LP+G LE+ GR D Q+KIRG+R++L EIE Sbjct: 821 LHQPELTAEKFLDNPYQPGERMYRTGDLALWLPDGQLEFLGRIDHQVKIRGHRIELGEIE 880 Query: 2607 STLDHIPFIQQSIVTATLDHEGEQAIAAYYVLKEPAAEKDIIRLLREQLPAYLIPRYWIE 2666 S L + P I++++V D G + + AY VL++ +++++ L + LP Y+IP +++ Sbjct: 881 SRLLNHPAIKEAVVIDRADETGGKFLCAYVVLQKALSDEEMRAYLAQALPEYMIPSFFVT 940 Query: 2667 LKFFPMTGPNKVDRNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDD 2726 L+ P+T K DR ALP P+ S + +YV P E+E L +W ++LG+ IG+ D Sbjct: 941 LERIPVTPNGKTDRRALPKPEG--SAKTKADYVAPTTELEQKLVAIWEQILGVSPIGIQD 998 Query: 2727 GFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTISSLATFLK 2772 FF +GGHSL +Q+ + ++KE + V + LF+ PTI +LA +++ Sbjct: 999 HFFTLGGHSLKAIQLISRIQKECQADVPLRVLFEQPTIQALAAYVE 1044 Score = 113 bits (283), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 83/303 (27%), Positives = 135/303 (44%), Gaps = 22/303 (7%) Query: 1634 YVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGDSLKAIHVISSIRKQFDCNLTLTD 1693 Y T+ E+ L I+ + LG + +G +D+FFEL GDS+KAI V + + L + + Sbjct: 3038 YAAPQTELEQLLAGIWADVLGIKQVGTQDNFFELGGDSIKAIQVSTRLNAS-GWTLAMKE 3096 Query: 1694 FFQNKTIKSVARFIRNASRANERQIAPVNPKSHYPTSLAQKRIFFLQGLMPDTVGYNEST 1753 FQ TI+ A + SR +E+ + +L + +F D +N++ Sbjct: 3097 LFQYPTIEEAALRVIPNSRESEQGVVEGE------IALTPIQKWFFANNFTDRHHWNQAV 3150 Query: 1754 SVLLEGNINAGRIEEVFAQIINRHESLRTSFRAENGEIVQIIHPHVD-------FKLIRT 1806 + E + G + + F QI+ H++LR ++ E+G I QI D + L Sbjct: 3151 MLFREDGFDEGLVRQAFQQIVEHHDALRMVYKQEDGAIKQINRGLTDERFRFYSYDLKNH 3210 Query: 1807 AVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVVDMHHIIADGTSVNLLVND 1866 A E I E ++ DL PL+ V L + +LV +HH++ DG S +L D Sbjct: 3211 ANSEARILELSDQIQSSIDLEHGPLVHVALFATKDGDHLLVA-IHHLVVDGVSWRILFED 3269 Query: 1867 FADLYMGK------ILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLEKLAGPLPVLTLP 1920 F+ Y +LP +KD+A Q + S+ + YW L LP Sbjct: 3270 FSSAYSQALHQQEIVLPKKTDSFKDWAAQLQKYADSDELLREVAYW-HNLETTTTTAALP 3328 Query: 1921 TDY 1923 TD+ Sbjct: 3329 TDF 3331 >emb|CAE02630.1| surfactin synthetase A [Bacillus amyloliquefaciens] Length = 3584 Score = 648 bits (1671), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/1148 (34%), Positives = 620/1148 (54%), Gaps = 43/1148 (3%) Query: 1634 YVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGDSLKAIHVISSIRKQFDCNLTLTD 1693 Y +TE+ L I++ LG GI D FFE G SLKA+ +++ I KQ + L Sbjct: 969 YAAPRNETEETLAVIWQEVLGMDKAGIYDHFFESGGHSLKAMTLLTKIHKQMGVEIPLQY 1028 Query: 1694 FFQNKTIKSVARFIRNASRANE-RQIAPVNPKSHYPTSLAQKRIFFLQGLMPDTVGYNES 1752 F++ TI ++A + N + R I P ++ YP SLAQ+R + VGYN Sbjct: 1029 LFEHPTIAALADYAENRNEGPAFRAIEPAEKQASYPLSLAQQRTYIASQFEDAGVGYNMP 1088 Query: 1753 TSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAENGEIVQIIHPHVDFKLIRTAVKEQG 1812 + ++EG ++ ++E F+ +I+RHE+LRTSF++E+G Q+I HV F + + + Sbjct: 1089 AAAMIEGALDREKLERAFSALISRHEALRTSFQSEDGTPRQVIGEHVPFHIEMIEARGRT 1148 Query: 1813 IEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVVDMHHIIADGTSVNLLVNDFADLYM 1872 E+ ++ F++ FDL+ APL R+GL G + +L+ DMHH+I+DG S+++++ + AD+Y Sbjct: 1149 NEQVMKDFVRRFDLSEAPLFRIGLQTLGHNRHMLLFDMHHLISDGVSISIMLKELADIYG 1208 Query: 1873 GKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLEKLAGPLPVLTLPTDYPRPAALSFQ 1932 G LP L IQYKDYA W Q E Y+ + YW E +G LPVL L DYPRP SF+ Sbjct: 1209 GNQLPELRIQYKDYAVW-QAERAKEGYKKERAYWKEVFSGELPVLQLLPDYPRPQVQSFE 1267 Query: 1933 GGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXXXXXXXXSGESDILIGIPQAGRNHE 1992 G R++ +L + ER++K +++ T +M + SG+ DI++G P AGRNH Sbjct: 1268 GDRVSAKLPKMLRERLQKLAEKNGATLYMVLLSAYYTLLSKYSGQEDIIVGTPSAGRNHS 1327 Query: 1993 DVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEVRASLLEALENQDFQIEMIVDQLDY 2052 D + ++GMFVN+L LR+ ++ + F L VR +L+A +QD+ E + ++L+ Sbjct: 1328 DTEGLIGMFVNTLALRSS----VKQDQTFAGLLGHVRKQVLDAFSHQDYPFEWLTEELNV 1383 Query: 2053 KRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLSPYPMTSKTTKADLNIHLYEVPSGI 2112 RD R ++DT+F S++N ++ A + ++ LS + K DL + E GI Sbjct: 1384 PRDMSRHPIFDTMF---SLQNASDGIAE-IGNLTLSLHETNFNIAKFDLTMQARETAEGI 1439 Query: 2113 YVECFYRTDLFKRETVQYIFEEYRRLIEAIPEQAGRTIGELPVFRQNDIPPAGGNVSPPV 2172 ++ Y T LFKR T + Y RL+E+ Q I E + + + ++ Sbjct: 1440 ALDLDYCTKLFKRSTADRMLAHYVRLLESAAAQPDAKISEYDLLSEREA------LNQLQ 1493 Query: 2173 RFQAFHYNDPA-ENLVQRFEKQVAAYPAHTAVKYREESLNYRQLNEQANRIARRIWELKE 2231 RF P + +VQ FE+Q P TA+++ E+L+Y+QLNE+ANR+AR I + Sbjct: 1494 RFNPERTVYPKDQTIVQIFEEQARKNPDRTALQFEGETLSYQQLNERANRLARHILSVG- 1552 Query: 2232 QESVERPVALLFGNTIEMVAALAGAIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDS 2291 + A+L +++M+ ++ +KAG +VP+D P+QR+ H D+ A ++LT Sbjct: 1553 --GGGKTAAVLCERSMDMIVSIMAVLKAGSAYVPIDPEHPVQRIQHFFRDSGANVLLT-- 1608 Query: 2292 ENESIARELAERVHAK-VTIVNTAEGLSGVSAENPSVCPDGDQTAFILYTSGSSGIPKGV 2350 + + LAE+ + V ++ E + NP++ D A + YTSG++G PKG Sbjct: 1609 --QQSLKPLAEKAGFQGVIVLADDEASYEKDSRNPALPFDSKTIANLTYTSGTTGTPKGN 1666 Query: 2351 VQSYRNIAFYIAQFTHSLAVNHQDRMALLTTYSHAIGILDILASLLNGATLHLC--DLKL 2408 + ++ NI + T+ L V+ +D + L+ Y + D+ SLLNGA L + D L Sbjct: 1667 IVTHANI-LRTVKNTNYLTVSEEDTVLGLSNYVFDAFMFDMFGSLLNGAKLVIVPKDTVL 1725 Query: 2409 DASIQRLSSWLNSEGITLYHSVPSVFRFLMKNLPGDVKLPSLRMVLLGGEVVTRADFELY 2468 D S RLS + E +++ ++F L+ P L +LR ++ GGE RA E Sbjct: 1726 DMS--RLSRVIKRENVSILMITTALFHLLVDMEPS--CLTTLRKIMFGGE---RASVEHV 1778 Query: 2469 KKNCAE--HCLFVNFLGCSELMVISFYTLDKGSEVNHARLPAGYAVDGIDVRIVGESGR- 2525 KK A ++ G SE V + Y E + +P G V +V I+ +GR Sbjct: 1779 KKALAAVGKGRLLHMYGPSESTVFATYHPVDVIEEDTLSVPIGKPVSNTEVFIMNSAGRI 1838 Query: 2526 -EAGIFEVGQLVYQSEYLSPGYWNQAGVTERVFASGPDSGAKRLYRSGDYGRLLPNGCLE 2584 AGI G+L E L GY+N+ +TE F P +R+Y++GD R LPNG +E Sbjct: 1839 QPAGI--AGELCVSGEGLVEGYYNRPELTEEKFVKHPFKEGERMYKTGDLARWLPNGDIE 1896 Query: 2585 YHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATLDHEGEQAIAAYYVLKEPAAE 2644 + GR D Q+KIRG R++L EIE L IQ+ IV A G++ + AY V + Sbjct: 1897 FIGRIDHQVKIRGQRIELGEIEHQLQSHDQIQECIVLAVDQGAGDKLLCAYVVGLREISS 1956 Query: 2645 KDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNALPAPDAIPSNDLRHEYVPPRNE 2704 +++ + LPAY+IP +I+L P+TG K+DR ALP PD +N + Y PRNE Sbjct: 1957 RELREHTAKDLPAYMIPSVFIQLDELPLTGNGKIDRRALPMPDVTAANAV--SYTAPRNE 2014 Query: 2705 MENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTI 2764 E LA +W EVL ++ +GV D FFEIGGHSL M++ ++K + + + DLF PT Sbjct: 2015 TEQKLADIWAEVLQMERVGVHDQFFEIGGHSLAGMKLLALIQKTFGVQLTLKDLFTSPTA 2074 Query: 2765 SSLATFLK 2772 + LA ++ Sbjct: 2075 AGLAQLIE 2082 Score = 605 bits (1560), Expect = e-171, Method: Compositional matrix adjust. Identities = 371/1174 (31%), Positives = 597/1174 (50%), Gaps = 65/1174 (5%) Query: 1618 PVTRKSQGKRPELP---------VAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELS 1668 P+T + R LP V+Y +TE+KL I+ L + +G+ D FFE+ Sbjct: 1983 PLTGNGKIDRRALPMPDVTAANAVSYTAPRNETEQKLADIWAEVLQMERVGVHDQFFEIG 2042 Query: 1669 GDSLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYP 1728 G SL + +++ I+K F LTL D F + T +A+ I R IAP + YP Sbjct: 2043 GHSLAGMKLLALIQKTFGVQLTLKDLFTSPTAAGLAQLIEGTERKAAESIAPAAERETYP 2102 Query: 1729 TSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAEN 1788 S QKR+F LQ L YN + + L+G ++A +++ V Q+ RHE+ RT+F ++ Sbjct: 2103 VSSPQKRMFVLQQLEGAETSYNMPSVLRLKGKLDAEKLKSVMKQLTERHEAFRTTFDIKD 2162 Query: 1789 GEIVQIIHPHVDFKLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSILVV 1848 GE VQ I D + E+ E ++ FI+PF L + PL+R GL++ E +L+ Sbjct: 2163 GETVQRIWTEADIDMEYYEASEEDAERIIQSFIRPFRLDQLPLVRTGLVKLAEHDHLLLF 2222 Query: 1849 DMHHIIADGTSVNLLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLE 1908 DMHHII+DG SV +L+++ + LY G+ L PL I YKDYA WQQ FI SE YR +E +WL Sbjct: 2223 DMHHIISDGASVGVLIDELSRLYGGETLEPLRIHYKDYAVWQQKFIQSEQYRKQEEHWLR 2282 Query: 1909 KLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXX 1968 +L G LPVLTLP DY RPA +F+G ++ L + ++ +++ T +M + Sbjct: 2283 ELDGELPVLTLPADYSRPAVQTFEGDKLVFSLTEEQTSALRSLAKQTDSTMYMVLLATYS 2342 Query: 1969 XXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEV 2028 SG+ DI++G P AGR+H D+ ++G+FVN+L LR P E K F +L+EV Sbjct: 2343 AFLSKLSGQHDIIVGSPVAGRSHADLANVIGVFVNTLALRTYP----EADKTFTDYLKEV 2398 Query: 2029 RASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLS 2088 + + L A + QD+ +E ++ +++ +RD R L+D +F SM+N E + ++L Sbjct: 2399 KQTALHAFDAQDYPLEDLLQKVEVQRDTSRNPLFDAVF---SMQN-ANAEDLVMEGIELK 2454 Query: 2089 PYPMTSKTTKADLNIHLYEVPSGIYVECFYRTDLFKRETVQYIFEEYRRLIEAIPEQAGR 2148 +P KT K DL + + + Y T LFK ET + + +L+EA E Sbjct: 2455 HHPFDRKTAKFDLTMTAEDTDEALTFVLEYNTALFKPETAETWKHYWLQLLEAAAENPAA 2514 Query: 2149 TIGELPVFRQNDIPP-----AGGNVSPPVRFQAFHYNDPAENLVQRFEKQVAAYPAHTAV 2203 + EL + + + G +S P R + H + FE A Y A Sbjct: 2515 KLSELSLVNKTEKQALLDAWKGKTISVP-RDKTVH---------RLFEDTAARYANRPAA 2564 Query: 2204 KYREESLNYRQLNEQANRIARRIWELKEQESVERPVALLFGNTIEMVAALAGAIKAGIPF 2263 Y Y +LN +ANRIAR + + + + V +L ++EM A + G +KAG F Sbjct: 2565 AYNGAKWTYGELNARANRIARILMDCG--VTADERVGILTKPSLEMAAGVLGVLKAGAAF 2622 Query: 2264 VPLDRSAPLQRLIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNTAEGLSGVSAE 2323 VP+D P +R+ +++ D+ A L+LT A + E + +++ + + + + Sbjct: 2623 VPIDPDYPEERISYILQDSGAKLLLTQE-----ALGVPESYKGETILLDGSRSILSLPLD 2677 Query: 2324 -----NPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQDRMAL 2378 NP D A+++YTSG++G PKGV+ + + + A+ D+ A Sbjct: 2678 ENDEANPQTETTADHLAYMIYTSGTTGQPKGVMVEHHALVNLCFWHHDAFAMTADDKSAK 2737 Query: 2379 LTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSSWLNSEGITLYHSVPSVFRFLM 2438 + I ++ + GA LH+ D + I RL+ + G+T+ + M Sbjct: 2738 YAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDITRLNHYFEEHGVTITFLPTQLAEQFM 2797 Query: 2439 KNLPGDVKLPSLRMVLLGGEVVTRADFELYKKNCAEHCLFVNFLGCSELMVISFYTLDKG 2498 D++ SLRM+L+GG+ + RA + Y +N G +E V++ + Sbjct: 2798 -----DLENTSLRMLLVGGDKLKRAVKQPYT--------IINNYGPTENTVVATSGVINP 2844 Query: 2499 SEVNHARLPAGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQAGVTERVFA 2558 E L G A+ V I+G+ + G+L L+ GY N+ T + F Sbjct: 2845 EE---GSLSIGRAIANTRVYILGDGDQVQPEGIAGELCVAGRGLARGYLNREEETAKRFT 2901 Query: 2559 SGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQS 2618 + P +R+YR+GD + +EY GR D Q+K+RGYR++L+EIE L + + + Sbjct: 2902 ADPFVPGERMYRTGDLVKWNAQCGIEYIGRIDQQVKVRGYRIELSEIEVRLAQLADVHDA 2961 Query: 2619 IVTATLDHEGEQAIAAYYVLKEPAAEKDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKV 2678 VTA D G A+ AY ++ E + L++ LP Y++P +W+E+ P+T K+ Sbjct: 2962 AVTAVEDKAGNTALCAYVAPQQDDIEA-LKSALKDTLPDYMVPAFWVEMDELPVTANGKI 3020 Query: 2679 DRNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLL 2738 D+ +LPAPD + Y P EME +L+ +W EVLG+ IGV D FF +GG S+ Sbjct: 3021 DKKSLPAPDIEAGS---AAYKAPETEMETLLSDIWQEVLGLDQIGVSDNFFTLGGDSIKG 3077 Query: 2739 MQVQNNLEKELKLTVEMGDLFKYPTISSLATFLK 2772 +Q+ + L + +EM DLF++PTI L ++++ Sbjct: 3078 IQMASRLNQH-GYKLEMKDLFQHPTIEELVSYVE 3110 Score = 378 bits (971), Expect = e-102, Method: Compositional matrix adjust. Identities = 299/1089 (27%), Positives = 520/1089 (47%), Gaps = 84/1089 (7%) Query: 1725 SHYPTSLAQKRIFFLQGLMPDTVGYNEST--SVLLEGNINAGRIEEVFAQIINRHESLRT 1782 + YP + AQKRI++ + P+T N + ++ E + A +E+ + + R+ES+R Sbjct: 4 TFYPLTNAQKRIWYTEKFYPNTSISNLAGFGKLISEDGVQAHYVEKAIQEFVRRYESMRI 63 Query: 1783 SFRAEN-GEIVQIIHPHVDFKLIRTAVKEQGIEE------AVERFIQPFDLARAPLIRVG 1835 R ++ GE VQ + + + T +++ G E +P L L R Sbjct: 64 RLRLDDEGEPVQYVSEYRPLSIGHTDIRQAGCSADELSKWGREEAGKPLALYDQDLFRFS 123 Query: 1836 LLQAGEQQSILVVDMHHIIADGTSVNLLVNDFADLYM----GKILPPLAI-QYKDYAEWQ 1890 + E + ++HHII+DG S+ +L N D+Y+ G I + ++ + Sbjct: 124 VHTISENEVWFYANVHHIISDGISMTILGNAITDIYLELSGGTSEEQTEIPSFIEHVLTE 183 Query: 1891 QGFITSEAYRSKETYWLEKLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKK 1950 Q ++ S+ ++ +W + +++L A R + E+ RI Sbjct: 184 QEYVQSKRFKKDRDFWNGQFETVPELVSLKRSR---ADAGLDAKRFSQEIPHDLYGRIHS 240 Query: 1951 FSQEQQVTWFMTMXXXXXXXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQ 2010 F +E +V+ +G D++ G R + ++M+GMFV+++ +R Sbjct: 241 FCEEHKVSVLSLFQSALITYLYKVTGRDDVVTGTFMGNRTNAKEKQMLGMFVSTVPVRTS 300 Query: 2011 PXXXXERKKPFLAFLQEVRASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQS 2070 + + FL F++ L++ L +Q + ++V+ L + + L+ YQ Sbjct: 301 ----VDGGQSFLEFVKGRMKDLMKILRHQKYPYNLLVNDLRASKS-SLSRLFTVALEYQV 355 Query: 2071 MKNQTETEASYLHDMKLSPYPMTSKTTKADLNIHLYEV--PSGIYVECFYRTDLFKRETV 2128 M+ Q + S+L D P+ S + D++IH+ E + ++ YR+D+FK E + Sbjct: 356 MQWQKKENLSFLTD------PIFSGSGTNDISIHVKERWDTGKLTIDFDYRSDIFKGEEI 409 Query: 2129 QYIFEEYRRLIEAIPEQAGRTIGELPVFRQND----IPPAGGNVSPPVRFQAFHYNDPAE 2184 + + E LIE R I EL + +++ + A GN PV ++ Sbjct: 410 ESVSERLITLIEDAISSPDRIIDELTLLSESEKERLLKRASGN---PVNYRG------EM 460 Query: 2185 NLVQRFEKQVAAYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVALLFG 2244 + FE++V + AV Y +L+YR L+EQ+ RIA R+ L+ S + PVA+L G Sbjct: 461 TIPGLFEEKVKSLSDKPAVVYEGRTLSYRTLHEQSGRIAGRL--LQAGISADSPVAVLLG 518 Query: 2245 NTIEMVAALAGAIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSENESIARELAERV 2304 + ++AA+ G +KAG +VP+D P R+ +++ D+ A +LT++ ++ A + AER+ Sbjct: 519 RSERVIAAILGILKAGGAYVPIDPDFPADRIQYILEDSGAKAVLTEAGIQAPAAD-AERI 577 Query: 2305 H--AKVTIVNTAEGLSGVSAENPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIA 2362 V A+G+S S D+ A+I+YTSG++G PKGV+ +R + + Sbjct: 578 DFDEAVQYETAADGVSTQS----------DRLAYIIYTSGTTGRPKGVMIEHRQVHHLVQ 627 Query: 2363 QFTHSLAVNHQD--RMALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSSWLN 2420 + + RMALL + + I ASLL G TL++ + L + Sbjct: 628 SLQQEIYQCGEQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKTTVTNGSALLDYYR 687 Query: 2421 SEGITLYHSVPSVFRFLMKNLPGDVKLPSLRMVLLGGEVVTRADFE----LYKKNCAEHC 2476 I P+ + ++ GDV LR +L+GGE ++ A E L+ ++ Sbjct: 688 QNRIEATDGTPAHLQMMVA--AGDVSGIELRHMLIGGEGLSAAVAEQLMALFHQSGRTPR 745 Query: 2477 LFVNFLGCSELMV---ISFYTLDKGSEVNHARLPAGYAVDGIDVRIVGESGREAGIFEVG 2533 L N G +E V + + D G A +P G + + I+ + R G Sbjct: 746 L-TNVYGPTETCVDASVHQVSADNGMNQQAAYVPIGKPLGNARLYILDKHQRLQPDGTAG 804 Query: 2534 QLVYQSEYLSPGYWNQAGVTERVFASGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQL 2593 +L + + GY N +T F P +G+ R+YR+GD R LP+G +EY GR D Q+ Sbjct: 805 ELYIAGDGVGRGYLNLPDLTAEKFLQDPFNGSGRMYRTGDMARWLPDGTIEYIGREDDQV 864 Query: 2594 KIRGYRVDLNEIESTLDHIPFIQQSIVTATLDHEGEQAIAAYYVLKE-----PAAEKDII 2648 K+RGYR++L EIE+ L P Q++V A D +G + AY V ++ PA ++ + Sbjct: 865 KVRGYRIELGEIETVLRKAPGAAQAVVLARPDQQGSLDVCAYIVQEKGTEFHPAEYREYV 924 Query: 2649 RLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNALPAPD--AIPSNDLRHEYVPPRNEME 2706 + LP Y++P Y+ + P+T K DR L A D A+ S+ EY PRNE E Sbjct: 925 ---SKHLPDYMVPAYFTKTDEIPLTPSGKADRKKLFALDVQAVSSS----EYAAPRNETE 977 Query: 2707 NMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTISS 2766 LA +W EVLG+ G+ D FFE GGHSL M + + K++ + + + LF++PTI++ Sbjct: 978 ETLAVIWQEVLGMDKAGIYDHFFESGGHSLKAMTLLTKIHKQMGVEIPLQYLFEHPTIAA 1037 Query: 2767 LATFLKDKH 2775 LA + ++++ Sbjct: 1038 LADYAENRN 1046 Score = 95.1 bits (235), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 75/309 (24%), Positives = 133/309 (43%), Gaps = 25/309 (8%) Query: 1618 PVTRKSQGKRPELPVAYVPAG--------TDTEKKLCAIYENHLGFQPIGIEDDFFELSG 1669 PVT + + LP + AG T+ E L I++ LG IG+ D+FF L G Sbjct: 3013 PVTANGKIDKKSLPAPDIEAGSAAYKAPETEMETLLSDIWQEVLGLDQIGVSDNFFTLGG 3072 Query: 1670 DSLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNPKSHYPT 1729 DS+K I + S + Q L + D FQ+ TI+ + ++ Q PV ++ Sbjct: 3073 DSIKGIQMASRL-NQHGYKLEMKDLFQHPTIEELVSYVERTEGKQADQ-GPVEGEA---- 3126 Query: 1730 SLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAENG 1789 +L + +F + D +N+S + + + E+ + H++LR +R + Sbjct: 3127 ALTPIQRWFFEKNFTDKHHWNQSVMLHAKDGFDPEITEKTLHVLTVHHDALRMIYREQKP 3186 Query: 1790 EIVQIIHPHVDFKLIR----TAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSI 1845 + V+ + E IE +R L L++ GL +A E Sbjct: 3187 YYRGLEDASVELNVFELNGPAEDHEDRIEREADRLQSSISLETGHLLKAGLFRA-EDGDH 3245 Query: 1846 LVVDMHHIIADGTSVNLLVNDFADLYMG------KILPPLAIQYKDYAEWQQGFITSEAY 1899 L++ +HH++ DG S +L+ DF +Y LPP + ++AE + + ++A+ Sbjct: 3246 LLLAIHHLVVDGVSWRILLEDFTSVYTQLKQGNEPALPPKTHSFAEFAERIKEYANTKAF 3305 Query: 1900 RSKETYWLE 1908 + YW E Sbjct: 3306 LKEADYWRE 3314 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.318 0.135 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 4,085,045,929 Number of extensions: 172548273 Number of successful extensions: 469911 Number of sequences better than 1.0e-05: 3931 Number of HSP's gapped: 449679 Number of HSP's successfully gapped: 6275 Length of query: 2806 Length of database: 757,237,578 Length adjustment: 143 Effective length of query: 2663 Effective length of database: 368,978,421 Effective search space: 982589535123 Effective search space used: 982589535123 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 135 (56.6 bits)