BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0486.0008.p (607 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|ZP_00100011.1| COG2972: Predicted signal transduction protei... 236 1e-60 ref|NP_358173.1| Histidine kinase [Streptococcus pneumoniae R6] ... 226 1e-57 ref|NP_345167.1| sensor histidine kinase, putative [Streptococcu... 225 3e-57 ref|NP_244314.1| two-component sensor histidine kinase [Bacillus... 223 1e-56 ref|NP_603097.1| Two-component sensor kinase yesM [Fusobacterium... 205 3e-51 >ref|ZP_00100011.1| COG2972: Predicted signal transduction protein with a C-terminal ATPase domain [Desulfitobacterium hafniense] Length = 577 Score = 236 bits (602), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 148/479 (30%), Positives = 247/479 (51%), Gaps = 13/479 (2%) Query: 111 ERM-DTLMSSREDLVSIAVFTPQGKYVVGTPGQNMRINTQLQSQSWFTSAVKNPEISYSA 169 ERM ++++ ++ SI + +G+ + M + +Q Q W+ A+ + ++ Sbjct: 101 ERMIQGMLNTNPEIASIILIGAKGQLITNEQNLEMHYSGDIQDQEWYQEALGSTMPILTS 160 Query: 170 PHIQNLFKGRYTWVVSISKMIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYI 229 +Q + WV+S+ + E + + G+L ID + I+ + + + LG+ GY+YI Sbjct: 161 ARMQEFSMDKDNWVISLGR--ELTDEKKKHLGVLRIDLKYDAIESILKDMSLGQEGYSYI 218 Query: 230 LDPLGNIVYHPQQQLIYAGLKYENVEPVLEYKFRSYLDESTGEKRFITVRTLDLTGWKIV 289 L+ +VYHP Q K + +LE + + E + E + L+ + W +V Sbjct: 219 LNQSQQVVYHPNPQYFSQEEKRLELIDMLEMEGK----ELSREYKLTHRYNLNNSDWVLV 274 Query: 290 GVAYYDEIVTTKRDLNHFLAWFXXXXXXXXXXXXXXXXXXXASPIRKLERTVKLVGEGDL 349 GVA D + + ++ L A PIR+LE+ ++ V +G L Sbjct: 275 GVASLDGVRRMEAEIIIVLVVLGSVLLLAAFGSSAIYASSVARPIRQLEKAMEEVEKGSL 334 Query: 350 NTPINVSGAYEVEQLSRRFNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPHFLYNT 409 T + V G+ E+ LS F ML RIR+LM +I +++ R EL+ L SQINPHFLYNT Sbjct: 335 ATEVGVVGSAEIASLSTHFLSMLDRIRELMQEIRNKEQFLRASELKTLYSQINPHFLYNT 394 Query: 410 LNSVIRLAERGKTDEVVTMIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQSFRFKN 469 L++++ LAE G T+ V+T+ +++++FFR+SL G T+++ELDH+R YL IQ R+++ Sbjct: 395 LDTIVWLAEFGNTERVITVSKAMARFFRLSLRGGSETTTVRDELDHVRQYLFIQKERYQD 454 Query: 470 KFRYEISAEEEVLACQTIKLILQPIVENALYHGIEMLPDEGLITITAELVEGL-IIIRVS 528 K YEI AE+ ++ K++LQP+VENA+YHG+ +P G+I ITA E + + V Sbjct: 455 KLSYEIQAEDGLMDITIPKILLQPLVENAIYHGLRKMPGGGMIRITARKGEKEDLFLVVE 514 Query: 529 DNGLGMXXXXXXXXXXXXXXXXXXXXXXXXXXXXIGLVYGREYGLAFESELEEGTTVTI 587 DNG G I L YG +YGL+ + +G T+ + Sbjct: 515 DNGGGF-----EDAEKGKDPLRLGGVGLKNVAERIRLYYGEDYGLSIANRPGQGATIIL 568 >ref|NP_358173.1| Histidine kinase [Streptococcus pneumoniae R6] pir||C97944 histidine kinase (EC 2.7.3.-) [imported] - Streptococcus pneumoniae (strain R6) gb|AAK99383.1| Histidine kinase [Streptococcus pneumoniae R6] Length = 563 Score = 226 bits (576), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 124/419 (29%), Positives = 233/419 (55%), Gaps = 10/419 (2%) Query: 115 TLMSSREDLVSIAVFTPQGKYVVGTPGQNMRINTQLQSQSWFTSAVKNPEISYSAPHIQN 174 T++ S +DL ++ + T G+ + M+ ++ + ++ W+ A+ + P + Sbjct: 97 TILKSDKDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAM----PVLTP 152 Query: 175 LFKGRYTWVVSISKMIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYILDPLG 234 K WV+S+++ + + + G+L +D ++ T++ Q++LG++G+A+I++ Sbjct: 153 ARKSDSQWVISVTQELVDAKGANL--GVLRLDISYETLEAYLNQLQLGQQGFAFIINENH 210 Query: 235 NIVYHPQQQLIYAGLKYENVEPVLEYKFRSYLDESTGEKRFITVRTLDLTGWKIVGVAYY 294 VYHPQ + + K E ++P +E + Y + G K +++ + T W ++GV+ Sbjct: 211 EFVYHPQHTVYSSSSKMEAMKPYIETG-QGY---TPGHKSYVSQEKIAGTDWTVLGVSSL 266 Query: 295 DEIVTTKRDLNHFLAWFXXXXXXXXXXXXXXXXXXXASPIRKLERTVKLVGEGDLNTPIN 354 +++ + L L +P++ L T+ + G N Sbjct: 267 EKLDQVRSQLLWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQNLRAK 326 Query: 355 VSGAYEVEQLSRRFNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPHFLYNTLNSVI 414 GAYE+ +++R+FN ML +I QLM I ++ET R+ +L+ L SQINPHFLYNTL+++I Sbjct: 327 EVGAYELREVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTII 386 Query: 415 RLAERGKTDEVVTMIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQSFRFKNKFRYE 474 +AE + VV + +SL+ +FR++L++GK++I + +E++H+R YL IQ R+ +K YE Sbjct: 387 WMAEFHDSQRVVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYE 446 Query: 475 ISAEEEVLACQTIKLILQPIVENALYHGIEMLPDEGLITITAELVEGLIIIRVSDNGLG 533 I+ KL+LQP+VENALYHGI+ +G I ++ + + ++IR+ D+G+G Sbjct: 447 INENVAFDNLVLPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVG 505 >ref|NP_345167.1| sensor histidine kinase, putative [Streptococcus pneumoniae TIGR4] pir||F95076 sensor histidine kinase, probable [imported] - Streptococcus pneumoniae (strain TIGR4) emb|CAB54581.1| histidine kinase [Streptococcus pneumoniae] gb|AAF31453.1| putative histidine kinase [Streptococcus pneumoniae] gb|AAK74807.1| sensor histidine kinase, putative [Streptococcus pneumoniae TIGR4] Length = 563 Score = 225 bits (573), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 124/423 (29%), Positives = 232/423 (54%), Gaps = 18/423 (4%) Query: 115 TLMSSREDLVSIAVFTPQGKYVVGTPGQNMRINTQLQSQSWFTSAVKNPEISYSAPHIQN 174 T++ S +DL ++ + T G+ + M+ ++ + ++ W+ A+ + P + Sbjct: 97 TILKSDKDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAM----PVLTP 152 Query: 175 LFKGRYTWVVSISKMIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYILDPLG 234 K WV+S+++ + + + G+L +D ++ T++ Q++LG++G+A+I++ Sbjct: 153 ARKSDSQWVISVTQELVDAKGANL--GVLRLDISYETLEAYLNQLQLGQQGFAFIINENH 210 Query: 235 NIVYHPQQQLIYAGLKYENVEPVLEYKFRSYLDE----STGEKRFITVRTLDLTGWKIVG 290 VYHPQ + + K E ++P Y+D + G K +++ + T W ++G Sbjct: 211 EFVYHPQHTVYSSSSKMEAMKP--------YIDTGQGYTPGHKSYVSQEKIAGTDWTVLG 262 Query: 291 VAYYDEIVTTKRDLNHFLAWFXXXXXXXXXXXXXXXXXXXASPIRKLERTVKLVGEGDLN 350 V+ +++ + L L +P++ L T+ + G N Sbjct: 263 VSSLEKLDQVRSQLLWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQN 322 Query: 351 TPINVSGAYEVEQLSRRFNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPHFLYNTL 410 GAYE+ +++R+FN ML +I QLM I ++ET R+ +L+ L SQINPHFLYNTL Sbjct: 323 LRAKEVGAYELREVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTL 382 Query: 411 NSVIRLAERGKTDEVVTMIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQSFRFKNK 470 +++I +AE + VV + +SL+ +FR++L++GK++I + +E++H+R YL IQ R+ +K Sbjct: 383 DTIIWMAEFHDSQRVVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDK 442 Query: 471 FRYEISAEEEVLACQTIKLILQPIVENALYHGIEMLPDEGLITITAELVEGLIIIRVSDN 530 YEI+ KL+LQP+VENALYHGI+ +G I ++ + + ++IR+ D+ Sbjct: 443 LEYEINENVAFDNLVLPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDD 502 Query: 531 GLG 533 G+G Sbjct: 503 GVG 505 >ref|NP_244314.1| two-component sensor histidine kinase [Bacillus halodurans] pir||G84080 two-component sensor histidine kinase BH3447 [imported] - Bacillus halodurans (strain C-125) dbj|BAB07166.1| two-component sensor histidine kinase [Bacillus halodurans] Length = 602 Score = 223 bits (568), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 159/557 (28%), Positives = 260/557 (46%), Gaps = 41/557 (7%) Query: 71 QIIEQVNYNLDLYAKGMANIFATAEEHITASPSIDSPL----------LSERMDTLMSSR 120 Q+I++VN ++ + + + N+ H +D L +S+ + + Sbjct: 53 QLIDKVNSTIEAHIENVQNMTYFISLHSNIQQFLDGTLEHLGPDEEYEISKFLQNFTTLY 112 Query: 121 EDLVSIAVFTPQGKYVVGTPGQNMRINTQLQSQSWFTSAVKNPEISY-----SAPHIQNL 175 ++ I V QG Y+ + R + L +SW+ AV+N I+ I + Sbjct: 113 PEIAGILVVNQQGDYL--SNELYTRSSFNLNQESWYRQAVENKGIAKLIGKPQGRRITSH 170 Query: 176 FKGRYTWVVSISKMIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYILDPLGN 235 R VV++ + I G+ KG++LID R I+E R V+LGK GY ++D G+ Sbjct: 171 VHYREDEVVTVVRAIIDSTTGE-EKGVILIDLKLRVIEEAVRDVRLGKSGYLMVVDQKGD 229 Query: 236 IVYHPQQQLIYAGLKYENVEPVLEYKFRS----YLDESTGEKRFITVRTLDLTGWKIVGV 291 +Y P ++Y E +++F + +E GE+ + + TGW ++GV Sbjct: 230 PIYSPAPSIMY--------EQSFDHRFSQNYGIFTEEVEGERYQLMYQQSAFTGWTLIGV 281 Query: 292 AYYDEIVTTKRDLNHFLAWFXXXXXXXXXXXXXXXXXXXASPIRKLERTVKLVGEGDLNT 351 D+ V + + ++ F + PI +L ++ GDL + Sbjct: 282 FSTDQSVEEVQQILFYVVTFVFFVCFVGITASYFLSYTISRPINQLMLAMQKAESGDLTS 341 Query: 352 PINVSGAYEVEQLSRRFNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPHFLYNTLN 411 EV +L R FN M+++I +L+ ++ KR+ EL LQ+ I PHFLYNTL+ Sbjct: 342 RYEGEEQDEVGRLGRSFNTMIEQIGKLISLTERQERKKREAELHSLQANIKPHFLYNTLD 401 Query: 412 SVIRLAERGKTDEVVTMIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQSFRFKNKF 471 ++ +A + +V ++ +LSK FRI LSKG +I + +E++HI++YL IQS R+KNK Sbjct: 402 TIQWMARKKNASDVADLVGALSKLFRIGLSKGGTIIPLVDEIEHIKNYLQIQSVRYKNKL 461 Query: 472 RYEISAEEEVLACQTIKLILQPIVENALYHGIEMLPDEGLITITAELVEGLIIIRVSDNG 531 Y + + +K++LQPIVENA+YHGI+ GLITI AE ++IIR+ DNG Sbjct: 462 NYSLVMPSNMERLSILKIVLQPIVENAIYHGIKERRGPGLITIEAERENDMLIIRIRDNG 521 Query: 532 LGMXXXXXXXXXXXXXXXXXXXXXXXXXXXXIG-----------LVYGREYGLAFESELE 580 G+ G L +G YG+ +S Sbjct: 522 KGIKPETLQQLRTNVNLFLEKGDKEGGQRLTKGYGLINVHARLRLTFGEPYGVKIDSVFN 581 Query: 581 EGTTVTICFPAVQAGTE 597 EGT VTI P ++ G E Sbjct: 582 EGTVVTIFHPILEGGVE 598 >ref|NP_603097.1| Two-component sensor kinase yesM [Fusobacterium nucleatum subsp. nucleatum ATCC 25586] gb|AAL94396.1| Two-component sensor kinase yesM [Fusobacterium nucleatum subsp. nucleatum ATCC 25586] Length = 552 Score = 205 bits (522), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 150/486 (30%), Positives = 242/486 (49%), Gaps = 40/486 (8%) Query: 113 MDTLMSSREDLVSIAVFTPQGKYVVGTPGQNMRINTQLQSQSWFTSAVKNPEISYSAPHI 172 +D +S+ + SI + G + NM +++ + + W+ +++ NP + Sbjct: 97 IDNTLSTDPYIKSIILIRKDGAVISNEKNVNMEVSSDMMKEEWYVNSLMNPMPVLNPLRK 156 Query: 173 QNL-FKGRYTWVVSISKMIEYKENGQIRKGILLIDFNFRTIDELSRQVKLGKRGYAYILD 231 QN G WV+S+S+ I NG+ G+LLID ++ + E + + GK ILD Sbjct: 157 QNFSLDGMDDWVISVSREIA-DTNGE-NLGVLLIDVKYQALHEYLQNQETGKNSDIVILD 214 Query: 232 PLGNIVYHPQQQLIYAGLKY-ENVEPVLEYKFRSYLDESTGEKRFITVR-TLDLTGWKIV 289 IVY+ + + KY +N++ + E R E+T +TV+ + T W ++ Sbjct: 215 EDNRIVYYKEIPYDTSQEKYLKNLKNIEEGYNRK---ENT-----VTVKYPIKNTHWTLI 266 Query: 290 GVAYYDEIVTTKRDLNHFLAWFXXXXXXXXXXXXXXXXXXX---ASPIRKLERTVKLVGE 346 ++Y EI + K NHF PI++LE+ + Sbjct: 267 EISYMQEIDSLK---NHFFEMIVISCLASLLITVLINISVLRRITKPIKELEQHMNNFN- 322 Query: 347 GDLNTPINVSGAYEVEQLS--RRFNMMLQRIRQLMDQIIYEQETKRKGELEVLQSQINPH 404 DL + IN+ G +E LS FN M+ +I+ L R+ E+ L SQINPH Sbjct: 323 NDL-SKINLKGDVSIEILSLQNHFNEMIDKIKYL-----------REYEINALYSQINPH 370 Query: 405 FLYNTLNSVIRLAERGKTDEVVTMIQSLSKFFRISLSKGKNMITMQEELDHIRHYLVIQS 464 FLYNTL+++I +AE T++V+++ ++LS FFRISLS GK I ++EE++HI+ YL IQ Sbjct: 371 FLYNTLDTIIWMAEFQDTEKVISITKALSNFFRISLSNGKEKIPLKEEINHIKEYLYIQK 430 Query: 465 FRFKNKFRYEISAEEEVLACQTIKLILQPIVENALYHGIEMLPDEGLITITAELVEGLII 524 R+++K Y+IS +EE+ + K+ILQP VENA+YHGI+ L G+I+I +++VE I Sbjct: 431 QRYEDKLEYKISIQEELENIEVPKIILQPFVENAIYHGIKNLDTTGIISIYSQIVENKIE 490 Query: 525 IRVSDNGLGMXXXXXXXXXXXXXXXXXXXXXXXXXXXXIGLVYGREYGLAFESELEEGTT 584 + + DNG+G I YG+EYG +S + G Sbjct: 491 LIIEDNGIGF------EAAKKQALMKMGGVGIKNVNKRIQYYYGKEYGAKIDSSFKTGAR 544 Query: 585 VTICFP 590 + I P Sbjct: 545 IIITLP 550 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.319 0.136 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 698,568,849 Number of extensions: 26042214 Number of successful extensions: 72258 Number of sequences better than 1.0e-05: 215 Number of HSP's gapped: 72027 Number of HSP's successfully gapped: 215 Length of query: 607 Length of database: 757,237,578 Length adjustment: 132 Effective length of query: 475 Effective length of database: 398,844,510 Effective search space: 189451142250 Effective search space used: 189451142250 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 129 (54.3 bits)