BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0476.0028.p (1145 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_242496.1| 5-methyltetrahydrofolate S-homocysteine methylt... 1496 0.0 ref|NP_980625.1| 5-methyltetrahydrofolate--homocysteine methyltr... 1387 0.0 ref|NP_833964.1| 5-methyltetrahydrofolate--homocysteine methyltr... 1383 0.0 ref|NP_658285.1| S-methyl_trans, Homocysteine S-methyltransferas... 1379 0.0 ref|ZP_00059561.1| COG1410: Methionine synthase I, cobalamin-bin... 801 0.0 >ref|NP_242496.1| 5-methyltetrahydrofolate S-homocysteine methyltransferase [Bacillus halodurans] pir||F83853 5-methyltetrahydrofolate S-homocysteine methyltransferase metH [imported] - Bacillus halodurans (strain C-125) dbj|BAB05349.1| 5-methyltetrahydrofolate S-homocysteine methyltransferase [Bacillus halodurans] Length = 1146 Score = 1496 bits (3872), Expect = 0.0, Method: Compositional matrix adjust. Identities = 734/1146 (64%), Positives = 881/1146 (76%), Gaps = 5/1146 (0%) Query: 1 VAKFTLAESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHE 60 + K + L+++I+ILDGAMGTM+Q LT DFGGEE +GCNE L T P +++ IH Sbjct: 1 MTKSLFEQQLERKIVILDGAMGTMLQAANLTADDFGGEEYEGCNEYLNETAPHVVEDIHR 60 Query: 61 KYLEAGADLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIG 120 YLEAGAD+I TNTFGAT +VL +YD+ +A E+N+ A ++A+ +++ TPD PR+V G Sbjct: 61 AYLEAGADVIATNTFGATDIVLDDYDLGYKAEELNICAVKIAKRVAEEFSTPDWPRFVAG 120 Query: 121 AMGPTTKTLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNA 180 AMGPTTK+LSVTGG TF++L++SY +QA LI G D LLLETSQD NVKA +G+ A Sbjct: 121 AMGPTTKSLSVTGGATFEQLIESYRQQATGLIKGGADILLLETSQDMRNVKAAYLGLSQA 180 Query: 181 FERSGITLPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRS 240 + + LP++ISGTIEPMGTTLAGQNIEAFY+SLEH+ P+ +GLNCATGPEFMRDH+RS Sbjct: 181 QKELEVKLPLIISGTIEPMGTTLAGQNIEAFYLSLEHMNPVVVGLNCATGPEFMRDHLRS 240 Query: 241 LSAISSAAVSCYPNAGLPDENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHIRA 300 LS +++ +VSCYPNAGLPDE GNYHESP+SLA KLAGFAEKGWLN+ GGCCGTTPDHIRA Sbjct: 241 LSDLATCSVSCYPNAGLPDEEGNYHESPESLAAKLAGFAEKGWLNMVGGCCGTTPDHIRA 300 Query: 301 MAEVLAEYPPRGLDGQHPPALSGIEPVYIESDNRPYMVGERTNVLGSRKFKRLIVEGKYE 360 + +V+ ++ PR G HP ++SGIEP+ + RP VGERTNV+GSRKFKRLI E KYE Sbjct: 301 LLDVMKQFEPRQPKGDHPHSVSGIEPLLYDDSMRPLFVGERTNVIGSRKFKRLIEEEKYE 360 Query: 361 EASEIARAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDPKVIDLA 420 EASEIAR+QVK GA VIDVC+ DPDRDE D+ +FL+ PLMID+TD KVI+ A Sbjct: 361 EASEIARSQVKKGAHVIDVCLADPDRDEMEDMEEFLKFVINKVKVPLMIDSTDEKVIEQA 420 Query: 421 LQYSQGKAIINSINLEDGEEKFELVTPLIHKYGAAIVVGTIDESGQAIKAADKLNVAKRS 480 L YSQGKAIINSINLEDGEE+FE V PL+HKYGAA+VVGTIDE G AI A KL VAKRS Sbjct: 421 LTYSQGKAIINSINLEDGEERFEKVVPLVHKYGAAVVVGTIDEEGMAITAEKKLAVAKRS 480 Query: 481 YELLVNKYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPEVHTILGISN 540 Y+LLVNKY + P D+IFD LVFPVGTGDEQYIGSA ET++GIR IKE LPE TILG+SN Sbjct: 481 YDLLVNKYNIRPSDIIFDPLVFPVGTGDEQYIGSANETVEGIRRIKEELPECLTILGVSN 540 Query: 541 VSFGLPEAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAEQLIYNTNDD 600 VSFGLP GREVLN+ +LY CT+AGLDYAIVNTEK+ERYASI ++E+ L+ +L++ T D+ Sbjct: 541 VSFGLPPVGREVLNAAYLYHCTQAGLDYAIVNTEKLERYASISDEEKELSRKLLFETTDE 600 Query: 601 TLSAFVAAFRGKKVEKKEKISNLSLEERLASYVVEGTKEGLIPDLNEALTK-SGPLEIIN 659 TL+ F A +RGKK EKK + SNL+LEERLA+Y+VEG+K+GL DL++AL K PL+IIN Sbjct: 601 TLAEFTAFYRGKKAEKKVETSNLTLEERLANYIVEGSKDGLTEDLDKALAKYDDPLDIIN 660 Query: 660 GPLMAGMSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQKD-ETSVKGKIMLATVK 718 GPLM GM EVGRLFNNNELIVAEVLQSAEVMKASV+HLE M+K + KGKI+LATVK Sbjct: 661 GPLMNGMDEVGRLFNNNELIVAEVLQSAEVMKASVAHLEPHMEKKADDHGKGKIILATVK 720 Query: 719 GDVHDIGKNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKADAIGLSGLLVKSAQQMV 778 GDVHDIGKNLVEIILSNNG+ I+NLGIKV +IEA RE DAIGLSGLLVKSAQQMV Sbjct: 721 GDVHDIGKNLVEIILSNNGFRIVNLGIKVTSNELIEAVARENPDAIGLSGLLVKSAQQMV 780 Query: 779 LTAQDLRTAGIDVPIMVGGAALTRKFTKTRIRPEYDGLVLYAKDAMDGLDIANRLMNPEE 838 LTAQDL+ I +PI+VGGAALTRKFT T+I PEYDGLV+YAKDAM+GL++AN+LM P+E Sbjct: 781 LTAQDLKQQQISIPILVGGAALTRKFTNTKIAPEYDGLVVYAKDAMNGLELANKLMKPDE 840 Query: 839 RVKIXXXXXXXXXXXXXXXXX--XXXXXLTRAVRSKISPDAPVFTPPDLERHVLRNYPLG 896 R K+ + RS +S PV PPD++ H+LR++ + Sbjct: 841 REKLAVSLHEAKEQANSRTQMGGGGTAVAVKPTRSHVSTTVPVAVPPDVKPHILRHHSIA 900 Query: 897 HIIPYVNMQMLLGHHLGLKGSVEAQLAAGDPRTVELKETVDEILHHAMLEGTMTPHAMYQ 956 H+ PY+NMQMLLG HLGL+G V LA D + +ELKE VD +L E M H MYQ Sbjct: 901 HLEPYINMQMLLGRHLGLQGKVSRLLAEKDEKALELKEKVDALLTRVKEEQLMEAHGMYQ 960 Query: 957 FFPAQSKGNDILIYDPQDTATVLHTFTFPRQNVEPYLCLADFLKSVDSGIMDYVGFLVVT 1016 FFPAQS G+DI+IYD Q + F FPRQN EPYLCLADFL+ V SG MDYVGFL VT Sbjct: 961 FFPAQSDGDDIVIYD-QTGTNEIERFHFPRQNKEPYLCLADFLRPVSSGEMDYVGFLAVT 1019 Query: 1017 AGHGIREMSAELRDKGDYLRSHXXXXXXXXXXXXXXXXXHHMMRDTWGFPDPADMTMKQR 1076 AG GIRE+ + ++ GDYL SH H +MRD WGFPD AD TM++R Sbjct: 1020 AGKGIRELGEQAKEAGDYLFSHLIQATALEMAEGFAERVHQLMRDKWGFPDSADFTMEER 1079 Query: 1077 HGARYQGIRVSFGYPACPDLEDQGPLFKLMSPGDIGVELTEGFMMEPEASVSAMVFAHPE 1136 A+Y+GIRVSFGYPACPDL+DQ LFKL+ PG IG+ELTEGFMMEPEASV+AMVFAHPE Sbjct: 1080 FAAKYRGIRVSFGYPACPDLDDQAKLFKLLKPGKIGIELTEGFMMEPEASVTAMVFAHPE 1139 Query: 1137 AQYFNV 1142 A+YFNV Sbjct: 1140 ARYFNV 1145 >ref|NP_980625.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Bacillus cereus ATCC 10987] gb|AAS43233.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Bacillus cereus ATCC 10987] Length = 1132 Score = 1387 bits (3590), Expect = 0.0, Method: Compositional matrix adjust. Identities = 690/1141 (60%), Positives = 845/1141 (74%), Gaps = 17/1141 (1%) Query: 6 LAESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHEKYLEA 65 + E LQ ILILDGAMGTMIQQ LT DFGGEE +GCNE LV TRP++I IH+ Y+EA Sbjct: 4 IEEKLQNNILILDGAMGTMIQQEDLTAEDFGGEEYEGCNEYLVETRPDVILKIHKAYIEA 63 Query: 66 GADLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIGAMGPT 125 GAD+IETNTFGAT++VL++Y++ E+N +AARLA+ AV++ + YV GAMGPT Sbjct: 64 GADIIETNTFGATNIVLSDYELSHLDEELNEKAARLAKQAVEE---SGKEVYVAGAMGPT 120 Query: 126 TKTLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNAFERSG 185 TK +SVTGGVTF+EL+++Y QA L+ G+VD LL+ETSQD NVKA IGI+ AF+ Sbjct: 121 TKAISVTGGVTFEELIEAYTRQARGLLKGEVDVLLVETSQDMRNVKAAYIGIQAAFDELN 180 Query: 186 ITLPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRSLSAIS 245 +P+MISGTIEPMGTTLAGQ IEAFY+S+EH+KP+S+GLNCATGPEFMRDHIRSLS +S Sbjct: 181 TIVPIMISGTIEPMGTTLAGQTIEAFYLSVEHMKPLSVGLNCATGPEFMRDHIRSLSDLS 240 Query: 246 SAAVSCYPNAGLPDENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHIRAMAEVL 305 +SCYPNAGLPDE+G+YHESP SLA K+ FAE+GW+NI GGCCGTTP+HI+AM L Sbjct: 241 ECYISCYPNAGLPDEDGHYHESPSSLAEKVKRFAEEGWVNIIGGCCGTTPEHIKAMKSAL 300 Query: 306 AEYPPRGLDGQHPPALSGIEPVYIESDNRPYMVGERTNVLGSRKFKRLIVEGKYEEASEI 365 PR + +SG+E + + RP VGERTNV+GSRKFKRL+ EGK+EEA+EI Sbjct: 301 TSLKPREQQERAGHGVSGLEALQYDDSMRPLFVGERTNVIGSRKFKRLVAEGKFEEAAEI 360 Query: 366 ARAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDPKVIDLALQYSQ 425 ARAQVK A +ID+C+ DPDRDE D+ FL P+MID+TD V++ AL Y Q Sbjct: 361 ARAQVKKNAHIIDICMADPDRDEIEDMENFLAEVTKVLKVPIMIDSTDEHVMERALTYIQ 420 Query: 426 GKAIINSINLEDGEEKFELVTPLIHKYGAAIVVGTIDESGQAIKAADKLNVAKRSYELLV 485 GKA+INSINLEDGEE+F+ VTPL+ KYGAAIVVGTIDE G A+ A KL +AKRSYELL Sbjct: 421 GKAVINSINLEDGEERFKKVTPLLRKYGAAIVVGTIDEDGMAVSAERKLEIAKRSYELLT 480 Query: 486 NKYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPEVHTILGISNVSFGL 545 KYG+ P D+IFD LVFPVGTGDE+YIGSA TI+GIRLIKEALPE TILG+SN+SFGL Sbjct: 481 TKYGIRPSDIIFDALVFPVGTGDEEYIGSAAATIEGIRLIKEALPECLTILGVSNISFGL 540 Query: 546 PEAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAEQLIYNTNDDTLSAF 605 P AGREVLNSVFLY TKAGLDYAIVNTEK+ERYASIP++E+ LA+ L++ T +TL F Sbjct: 541 PPAGREVLNSVFLYHATKAGLDYAIVNTEKLERYASIPDEEKRLADALLFETTQETLEKF 600 Query: 606 VAAFRGKKVEKKEKI---SNLSLEERLASYVVEGTKEGLIPDLNEALTKS-GPLEIINGP 661 +R V KK+ + L+L+ERLA+Y+VEGTK+GL DL+ ALT+ PL+IINGP Sbjct: 601 TNFYR---VAKKKDVVVQETLTLDERLANYIVEGTKQGLHEDLSLALTEGRKPLDIINGP 657 Query: 662 LMAGMSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQKDETSVKGKIMLATVKGDV 721 LM GM EVGRLFNNNELIVAEVLQSAE MKA+VS+LE M+ +++ KGK++LATVKGDV Sbjct: 658 LMTGMDEVGRLFNNNELIVAEVLQSAESMKAAVSYLEPHMESSDSAKKGKVLLATVKGDV 717 Query: 722 HDIGKNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKADAIGLSGLLVKSAQQMVLTA 781 HDIGKNLVEIIL+NNGYEIINLGI V + I++ + +K D IGLSGLLVKSAQQMV TA Sbjct: 718 HDIGKNLVEIILANNGYEIINLGINVRSDRIVQEVQEKKPDIIGLSGLLVKSAQQMVTTA 777 Query: 782 QDLRTAGIDVPIMVGGAALTRKFTKTRIRPEYDGLVLYAKDAMDGLDIANRLMNPEERVK 841 +DL+ A ID+PI+VGGAALTRKFT RI P Y GLV YA DAM GLDI N+L EER K Sbjct: 778 EDLKAADIDIPIVVGGAALTRKFTDNRISPSYKGLVCYASDAMTGLDIINKLQKEEEREK 837 Query: 842 IXXXXXXXXXXXXXXXXXXXXXXLTRAVRSKISPDAPVFTPPDLERHVLRNYPLGHIIPY 901 + AV + P A V P +R VLR+ P+ H+ P+ Sbjct: 838 MKQDKKERHLHIVTKEEKKVEIP---AVIEPL-PKAEVIVPDSTKRIVLRDVPVSHLAPF 893 Query: 902 VNMQMLLGHHLGLKGSVEAQLAAGDPRTVELKETVDEILHHAMLEGTMTPHAMYQFFPAQ 961 +N QMLLGHHLGLKGSV+ L GD R EL + +DE+L + + P A+YQFFPAQ Sbjct: 894 LNRQMLLGHHLGLKGSVKKLLREGDKRAHELNDLIDELLQEG--QSWLKPKAVYQFFPAQ 951 Query: 962 SKGNDILIYDPQDTATVLHTFTFPRQNVEPYLCLADFLKSVDSGIMDYVGFLVVTAGHGI 1021 S G +I+IYDP+D V+ FTFPRQ PY L D+L+ V MDYV FL VT G G+ Sbjct: 952 SDGQNIVIYDPEDHTRVIERFTFPRQGKAPYRTLGDYLRPVGDE-MDYVAFLSVTVGEGV 1010 Query: 1022 REMSAELRDKGDYLRSHXXXXXXXXXXXXXXXXXHHMMRDTWGFPDPADMTMKQRHGARY 1081 R+++ E + KGDYLRSH H ++RD WG PD ++TM++R +Y Sbjct: 1011 RDIAEEWKAKGDYLRSHAIQSLALELAEGLAEKTHMLIRDRWGIPDSPELTMEERFRTKY 1070 Query: 1082 QGIRVSFGYPACPDLEDQGPLFKLMSPGDIGVELTEGFMMEPEASVSAMVFAHPEAQYFN 1141 +GIRVSFGYPACP+L DQ LF+L+ P +IG+ LTEGFMMEPEASV+AMVF+HPEA+YF+ Sbjct: 1071 RGIRVSFGYPACPELADQEKLFRLIHPEEIGISLTEGFMMEPEASVTAMVFSHPEARYFS 1130 Query: 1142 V 1142 V Sbjct: 1131 V 1131 >ref|NP_833964.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Bacillus cereus ATCC 14579] gb|AAP11165.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Bacillus cereus ATCC 14579] Length = 1133 Score = 1383 bits (3580), Expect = 0.0, Method: Compositional matrix adjust. Identities = 689/1142 (60%), Positives = 843/1142 (73%), Gaps = 17/1142 (1%) Query: 5 TLAESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHEKYLE 64 + E L+ ILILDGAMGTMIQQ LT DFGGEE +GCNE LV TRP++I IH+ Y+E Sbjct: 4 CIEEKLKNSILILDGAMGTMIQQEDLTAEDFGGEEYEGCNEYLVETRPDVILKIHKAYIE 63 Query: 65 AGADLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIGAMGP 124 AGAD+IETNTFGAT++VL++YD+ E+N EAA LA+ AV + + YV GAMGP Sbjct: 64 AGADIIETNTFGATNIVLSDYDLSHLDEELNEEAALLAKQAVKE---SGKEVYVAGAMGP 120 Query: 125 TTKTLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNAFERS 184 TTK +SVTGGVTF+EL+++Y QA L+ G VD +L+ETSQD NVKA IGI+ AFE Sbjct: 121 TTKAISVTGGVTFEELIEAYTRQARGLLKGAVDVVLVETSQDMRNVKAAYIGIQAAFEEL 180 Query: 185 GITLPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRSLSAI 244 T+P+MISGTIEPMGTTLAGQ IEAFY+S+EH+KP+S+GLNCATGPEFMRDHIRSLS + Sbjct: 181 KKTVPIMISGTIEPMGTTLAGQTIEAFYLSVEHMKPLSVGLNCATGPEFMRDHIRSLSDL 240 Query: 245 SSAAVSCYPNAGLPDENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHIRAMAEV 304 S +SCYPNAGLPDE+G+YHESP SLA K+ FAE+GW+NI GGCCGTTP+HI+AM Sbjct: 241 SECYISCYPNAGLPDEDGHYHESPSSLAEKVKRFAEEGWVNIIGGCCGTTPEHIKAMKSA 300 Query: 305 LAEYPPRGLDGQHPPALSGIEPVYIESDNRPYMVGERTNVLGSRKFKRLIVEGKYEEASE 364 LA PR + +SG+E + + RP VGERTNV+GSRKFKRL+ EGK+EEA+E Sbjct: 301 LASLRPRDHHEREGHGISGLEALQYDESMRPLFVGERTNVIGSRKFKRLVAEGKFEEAAE 360 Query: 365 IARAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDPKVIDLALQYS 424 +ARAQVK A +ID+C+ DPDRDE D+ FL P+MID+TD V++ AL Y Sbjct: 361 VARAQVKKNAHIIDICMADPDRDEIEDMENFLAEVTKVLKVPIMIDSTDENVMERALTYI 420 Query: 425 QGKAIINSINLEDGEEKFELVTPLIHKYGAAIVVGTIDESGQAIKAADKLNVAKRSYELL 484 QGKA+INSINLEDGEE+F+ VTPL+ KYGAAIVVGTIDE G A+ A K+ +AKRSYELL Sbjct: 421 QGKAVINSINLEDGEERFKKVTPLLQKYGAAIVVGTIDEDGMAVSAERKIEIAKRSYELL 480 Query: 485 VNKYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPEVHTILGISNVSFG 544 KYG+ P D+IFD LVFPVGTGDE+YIGSA TI+GIRLIKEALPE TILG+SN+SFG Sbjct: 481 TKKYGIRPSDIIFDALVFPVGTGDEEYIGSAAATIEGIRLIKEALPECLTILGVSNISFG 540 Query: 545 LPEAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAEQLIYNTNDDTLSA 604 LP AGREVLNSVFLY TKAGLDYAIVNTEK+ERYASIPE+E+ LA+ L++ T +TL Sbjct: 541 LPPAGREVLNSVFLYHATKAGLDYAIVNTEKLERYASIPEEEKRLADALLFETTKETLEE 600 Query: 605 FVAAFRGKKVEKKEKI---SNLSLEERLASYVVEGTKEGLIPDLNEALTKS-GPLEIING 660 F +R V KK+ + L+L+ERLA+Y+VEGTK+GL DL+ AL + PL+IING Sbjct: 601 FTNFYR---VAKKKDVVVQETLTLDERLANYIVEGTKQGLHEDLSLALEEGRKPLDIING 657 Query: 661 PLMAGMSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQKDETSVKGKIMLATVKGD 720 PLM GM EVGRLFNNNELIVAEVLQSAE MKA+VS+LE M+ +++ KGK++LATVKGD Sbjct: 658 PLMTGMDEVGRLFNNNELIVAEVLQSAESMKAAVSYLEPHMESSDSAKKGKVLLATVKGD 717 Query: 721 VHDIGKNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKADAIGLSGLLVKSAQQMVLT 780 VHDIGKNLVEIIL+NNGYEIINLGI V + I++ + +K D IGLSGLLVKSAQQMV T Sbjct: 718 VHDIGKNLVEIILANNGYEIINLGINVRSDRIVQEVQEKKPDIIGLSGLLVKSAQQMVTT 777 Query: 781 AQDLRTAGIDVPIMVGGAALTRKFTKTRIRPEYDGLVLYAKDAMDGLDIANRLMNPEERV 840 A+DL+ A IDVPI+VGGAALTRKFT RI P Y GLV YA DAM GLDI N+L EER Sbjct: 778 AEDLKAANIDVPIVVGGAALTRKFTDNRISPSYKGLVCYASDAMTGLDIINKLQKEEERE 837 Query: 841 KIXXXXXXXXXXXXXXXXXXXXXXLTRAVRSKISPDAPVFTPPDLERHVLRNYPLGHIIP 900 K+ AV + P + V P +R VLR+ P H+ P Sbjct: 838 KMKQDKKERHLHIVKKEEKKVEIP---AVIEPL-PKSEVMVPDSTKRIVLRDVPALHLAP 893 Query: 901 YVNMQMLLGHHLGLKGSVEAQLAAGDPRTVELKETVDEILHHAMLEGTMTPHAMYQFFPA 960 ++N QMLLGHHLGLKG+V+ L GD R EL + +DE+L + + P A+YQFFPA Sbjct: 894 FLNRQMLLGHHLGLKGNVKKLLKEGDKRAHELNDLIDELLQEG--QSWLKPKAVYQFFPA 951 Query: 961 QSKGNDILIYDPQDTATVLHTFTFPRQNVEPYLCLADFLKSVDSGIMDYVGFLVVTAGHG 1020 QS G +I+IYDP+D V+ FTFPRQ PY L D+L+ + MDYV FL VT G G Sbjct: 952 QSDGQNIVIYDPEDHTRVIERFTFPRQGKAPYRTLGDYLRPIGDE-MDYVAFLSVTVGEG 1010 Query: 1021 IREMSAELRDKGDYLRSHXXXXXXXXXXXXXXXXXHHMMRDTWGFPDPADMTMKQRHGAR 1080 +R+++ EL+ KGDYLRSH H ++RD WG PD ++TM++R + Sbjct: 1011 VRDIAEELKAKGDYLRSHAIQSLALELAEGLAEKTHMLIRDRWGIPDSPELTMEERFRTK 1070 Query: 1081 YQGIRVSFGYPACPDLEDQGPLFKLMSPGDIGVELTEGFMMEPEASVSAMVFAHPEAQYF 1140 Y+GIRVSFGYPACP+L DQ LF+L+ P +IG+ LTEGFMMEPEASV+AMVF+HPEA+YF Sbjct: 1071 YRGIRVSFGYPACPELADQEKLFRLIHPEEIGISLTEGFMMEPEASVTAMVFSHPEARYF 1130 Query: 1141 NV 1142 +V Sbjct: 1131 SV 1132 >ref|NP_658285.1| S-methyl_trans, Homocysteine S-methyltransferase [Bacillus anthracis A2012] ref|NP_846703.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Bacillus anthracis str. Ames] gb|AAP28189.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Bacillus anthracis str. Ames] Length = 1132 Score = 1379 bits (3568), Expect = 0.0, Method: Compositional matrix adjust. Identities = 687/1143 (60%), Positives = 844/1143 (73%), Gaps = 17/1143 (1%) Query: 4 FTLAESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHEKYL 63 + + E LQ IL+LDGAMGTMIQQ LT DFGGEE +GCNE LV TRP++I IH+ Y+ Sbjct: 2 YCIEEKLQNNILLLDGAMGTMIQQEDLTAEDFGGEEYEGCNEYLVETRPDVILKIHKAYI 61 Query: 64 EAGADLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIGAMG 123 EAGAD+IETNTFGAT++VL++Y++ E+N +AARLA+ AV + + YV GAMG Sbjct: 62 EAGADIIETNTFGATNIVLSDYELSHLDEELNEKAARLAKQAVKE---SGKEVYVAGAMG 118 Query: 124 PTTKTLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNAFER 183 PTTK +SVTGGVTF+EL+++Y QA L+ G+VD LL+ETSQD N+KA IGI+ AF+ Sbjct: 119 PTTKAISVTGGVTFEELIEAYTRQARGLLKGEVDVLLVETSQDMRNMKAAYIGIQAAFDE 178 Query: 184 SGITLPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRSLSA 243 +P+MISGTIEPMGTTLAGQ IEAFY+S+EH+KP+S+GLNCATGPEFMRDHIRSLS Sbjct: 179 LKKIVPIMISGTIEPMGTTLAGQTIEAFYLSVEHMKPLSVGLNCATGPEFMRDHIRSLSD 238 Query: 244 ISSAAVSCYPNAGLPDENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHIRAMAE 303 +S +SCYPNAGLPDE+G+YHESP SLA K+ FAE+GW+NI GGCCGTTP+HI+AM E Sbjct: 239 LSECYISCYPNAGLPDEDGHYHESPSSLAEKVKRFAEEGWVNIIGGCCGTTPEHIKAMKE 298 Query: 304 VLAEYPPRGLDGQHPPALSGIEPVYIESDNRPYMVGERTNVLGSRKFKRLIVEGKYEEAS 363 LA PR + +SG+E + + RP VGERTNV+GSRKFKRL+ EGK+EEA+ Sbjct: 299 ALASLKPREHHEREGHGVSGLEALQYDDSMRPLFVGERTNVIGSRKFKRLVAEGKFEEAA 358 Query: 364 EIARAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDPKVIDLALQY 423 E+ARAQVK A +ID+C+ DPDRDE D+ FL P+MID+TD V++ AL Y Sbjct: 359 EVARAQVKKNAHIIDICMADPDRDEIEDMENFLAEVTKVLKVPIMIDSTDEHVMERALTY 418 Query: 424 SQGKAIINSINLEDGEEKFELVTPLIHKYGAAIVVGTIDESGQAIKAADKLNVAKRSYEL 483 QGKA+INSINLEDGEE+F VTPL+ KYGAAIVVGTIDE G A+ A KL +AKRSYEL Sbjct: 419 IQGKAVINSINLEDGEERFIKVTPLLQKYGAAIVVGTIDEDGMAVSAERKLEIAKRSYEL 478 Query: 484 LVNKYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPEVHTILGISNVSF 543 L KYG+ P D+IFD LVFPVGTGDE+YIGSA TI+GIRLIKEALPE TILG+SN+SF Sbjct: 479 LTTKYGIRPSDIIFDALVFPVGTGDEEYIGSAAATIEGIRLIKEALPECLTILGVSNISF 538 Query: 544 GLPEAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAEQLIYNTNDDTLS 603 GLP AGREVLNSVFLY TKAGLDYAIVNTEK+ERYASIP++E+ LA+ L++ T +TL Sbjct: 539 GLPPAGREVLNSVFLYHATKAGLDYAIVNTEKLERYASIPDEEKRLADALLFETTQETLE 598 Query: 604 AFVAAFRGKKVEKKEKI---SNLSLEERLASYVVEGTKEGLIPDLNEALTKS-GPLEIIN 659 F +R V KK+ + L+L+ERLA+Y+VEGTK+GL DL+ ALT+ PL+IIN Sbjct: 599 EFTNFYR---VAKKKDVVVQETLTLDERLANYIVEGTKQGLHEDLSLALTEGRKPLDIIN 655 Query: 660 GPLMAGMSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQKDETSVKGKIMLATVKG 719 GPLM GM EVGRLFNNNELIVAEVLQSAE MKA+VS+LE M+ +++ KGK++LATVKG Sbjct: 656 GPLMTGMDEVGRLFNNNELIVAEVLQSAESMKAAVSYLEPHMESSDSAKKGKVLLATVKG 715 Query: 720 DVHDIGKNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKADAIGLSGLLVKSAQQMVL 779 DVHDIGKNLVEIIL+NNGYEIINLGI V + I++ + +K D IGLSGLLVKSAQQMV Sbjct: 716 DVHDIGKNLVEIILANNGYEIINLGINVRSDRIVQEVQEKKPDIIGLSGLLVKSAQQMVT 775 Query: 780 TAQDLRTAGIDVPIMVGGAALTRKFTKTRIRPEYDGLVLYAKDAMDGLDIANRLMNPEER 839 TA+DL+ A ID+PI+VGGAALTRKFT RI P Y GLV YA DAM GLDI N+L EER Sbjct: 776 TAEDLKAADIDIPIVVGGAALTRKFTDNRISPSYKGLVCYASDAMTGLDIINKLQKEEER 835 Query: 840 VKIXXXXXXXXXXXXXXXXXXXXXXLTRAVRSKISPDAPVFTPPDLERHVLRNYPLGHII 899 K+ AV + P + V P +R VLR+ P H+ Sbjct: 836 EKMKQDKKERHLHIVTKEEKKIEIP---AVIEPL-PKSEVMVPDSTKRIVLRDVPALHLA 891 Query: 900 PYVNMQMLLGHHLGLKGSVEAQLAAGDPRTVELKETVDEILHHAMLEGTMTPHAMYQFFP 959 P++N QMLLGHHLGLKGSV+ L GD R EL + +DE+L + + P A+YQFFP Sbjct: 892 PFLNRQMLLGHHLGLKGSVKKLLKEGDKRAHELNDLIDELLQEG--QSWLKPKAVYQFFP 949 Query: 960 AQSKGNDILIYDPQDTATVLHTFTFPRQNVEPYLCLADFLKSVDSGIMDYVGFLVVTAGH 1019 AQS G +I+IYDP+D V+ FTFPRQ PY L D+L+ + MDYV FL VT G Sbjct: 950 AQSDGQNIVIYDPEDHTRVIERFTFPRQGRAPYRTLGDYLRPIGDE-MDYVAFLSVTVGE 1008 Query: 1020 GIREMSAELRDKGDYLRSHXXXXXXXXXXXXXXXXXHHMMRDTWGFPDPADMTMKQRHGA 1079 G+R ++ E + KGDYLRSH H ++RD WG PD ++TM++R Sbjct: 1009 GVRGIAEEWKAKGDYLRSHAIQSLALELAEGLAEKTHMLIRDRWGIPDSPELTMEERFRT 1068 Query: 1080 RYQGIRVSFGYPACPDLEDQGPLFKLMSPGDIGVELTEGFMMEPEASVSAMVFAHPEAQY 1139 +Y+GIRVSFGYPACP+L DQ LF+L+ P +IG+ LTEGFMMEPEASV+AMVF+HPEA+Y Sbjct: 1069 KYRGIRVSFGYPACPELADQEKLFRLIHPEEIGISLTEGFMMEPEASVTAMVFSHPEARY 1128 Query: 1140 FNV 1142 F+V Sbjct: 1129 FSV 1131 >ref|ZP_00059561.1| COG1410: Methionine synthase I, cobalamin-binding domain [Thermobifida fusca] Length = 1158 Score = 801 bits (2068), Expect = 0.0, Method: Compositional matrix adjust. Identities = 482/1175 (41%), Positives = 671/1175 (57%), Gaps = 53/1175 (4%) Query: 2 AKFTLAESLQQRILILDGAMGTMIQQVPLTGADFGGEELDGCNEMLVLTRPELIQGIHEK 61 A+ + E L R+L+ DGAMGTM+Q L+ DF G E GCNE+L +TRP++++ IHE Sbjct: 3 ARLSFREVLGSRVLVADGAMGTMLQTYDLSMDDFEGHE--GCNEVLNITRPDVVREIHEA 60 Query: 62 YLEAGADLIETNTFGATSVVLAEYDIPQRAREINLEAARLARNAVDKYDTPDRPRYVIGA 121 YL+AG D +ETNTFGA L EY I +R E+ ARLAR A D Y T D RYV+G+ Sbjct: 61 YLQAGVDCVETNTFGANFGNLGEYGIAERTYELAEAGARLAREAADAYTTADHVRYVLGS 120 Query: 122 MGPTTKTLSVTGGVTFQELVQSYEEQAAALIDGKVDALLLETSQDTLNVKAGSIGIRNAF 181 +GP TK L G + L YE+ A LIDG VDA+++ET QD L KA +G R A Sbjct: 121 VGPGTK-LPTLGHAPYAVLRDHYEQCARGLIDGGVDAIVIETCQDLLQAKAAIVGARRAR 179 Query: 182 ERSGITLPVMISGTIEPMGTTLAGQNIEAFYISLEHLKPISIGLNCATGPEFMRDHIRSL 241 + +G P+++ TIE GT L G I A SLE L IGLNCATGP M +H+R L Sbjct: 180 KAAGTDTPIIVQVTIETTGTMLVGSEIGAALTSLEPLGVDMIGLNCATGPAEMSEHLRYL 239 Query: 242 SAISSAAVSCYPNAGLPD---ENGNYHESPDSLARKLAGFAEKGWLNIAGGCCGTTPDHI 298 S S +SC PNAGLP+ + Y P L F + L + GGCCGTTP+H Sbjct: 240 SHHSRIPLSCMPNAGLPELGADGAVYPLQPHELTEAHDTFIREFGLALVGGCCGTTPEH- 298 Query: 299 RAMAEVLAEYPPRGLDGQHP---PALSGI-EPVYIESDNRPYMVGERTNVLGSRKFKRLI 354 +A+V+ RG+ + P PA + I + V D +GERTN GS+ F+ + Sbjct: 299 --LAQVVERVQGRGVPDRKPHVEPAAASIYQSVPFRQDTSYLAIGERTNANGSKAFREAM 356 Query: 355 VEGKYEEASEIARAQVKNGAQVIDVCVQDPDRDESADITKFLELXXXXXXXPLMIDTTDP 414 + +Y++ EIAR Q+++GA ++D+CV RD D+ + PL++D+T+ Sbjct: 357 LAERYDDCVEIARQQIRDGAHMLDLCVDYVGRDGVRDMRELASRLATASTLPLVLDSTEV 416 Query: 415 KVIDLALQYSQGKAIINSINLEDGE---EKFELVTPLIHKYGAAIVVGTIDESGQAIKAA 471 V++ L+ G+A++NS+N EDG+ +F V L ++GAA++ TIDE GQA A Sbjct: 417 AVLEAGLEMLGGRAVLNSVNYEDGDGPDSRFAKVAALAVEHGAALMALTIDEQGQARTAE 476 Query: 472 DKLNVAKRSYELLVNKYGLAPEDLIFDTLVFPVGTGDEQYIGSAKETIDGIRLIKEALPE 531 K+ VA+R L +YG+ D+I D L F + TG E+ A ETI+ IR +K P+ Sbjct: 477 RKVEVAERLIRQLTTEYGIRKHDIIVDCLTFTIATGQEESRRDALETIEAIRELKRRHPD 536 Query: 532 VHTILGISNVSFGLPEAGREVLNSVFLYECTKAGLDYAIVNTEKVERYASIPEQERYLAE 591 V T LG+SNVSFGL A R VLNSVFL+EC +AGLD AIV+ K+ IPE++R +A Sbjct: 537 VQTTLGVSNVSFGLNPAARIVLNSVFLHECVQAGLDSAIVHASKILPINRIPEEQRQVAL 596 Query: 592 QLIYN--TND-DTLSAFVAAFRG-----KKVEKKEKISNLSLEERLASYVVEGTKEGLIP 643 +IY+ T+D D L F+ F G + ++E+++ L L ERL +V+G G+ Sbjct: 597 DMIYDRRTDDYDPLQRFLQLFEGVDAQAMRASREEELAALPLWERLERRIVDGEAAGMEA 656 Query: 644 DLNEALTKSGPLEIINGPLMAGMSEVGRLFNNNELIVAEVLQSAEVMKASVSHLEQFMQK 703 DL+EALT+ L+IIN L+AGM VG LF + ++ + VL+SAEVMKA+V++LE M+K Sbjct: 657 DLDEALTQRSALDIINTTLLAGMKTVGDLFGSGQMQLPFVLKSAEVMKAAVAYLEPHMEK 716 Query: 704 DETSV-KGKIMLATVKGDVHDIGKNLVEIILSNNGYEIINLGIKVPPESIIEAFRREKAD 762 + + KG+I+LATVKGDVHDIGKNLV+IILSNNGYE+INLGIK P +I+EA R +AD Sbjct: 717 VDGDLGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVINLGIKQPISAILEAAERHRAD 776 Query: 763 AIGLSGLLVKSAQQMVLTAQDLRTAGI--DVPIMVGGAALTRKFTKTRIRPEYDGLVLYA 820 IG+SGLLVKS M +++ G+ P+++GGAALTR + + + + G V YA Sbjct: 777 VIGMSGLLVKSTVVMRENLEEMNARGVADRYPVLLGGAALTRSYVEQDLAEIFKGEVRYA 836 Query: 821 KDAMDGLDIANRLMNPEERVKIXXXXXXXXXXXXXXXXXXXXXXLTRAVRSKISPDAPVF 880 +DA +GL + + +M + VK RS ++ D PV Sbjct: 837 RDAFEGLKLMDAIMAVKRGVKGAKLPPLRTRRVKRGAQLTVTEPEKMPTRSDVATDNPVP 896 Query: 881 TPPDLERHVLRNYPLGHIIPYVNMQMLLGHHLGLKGSVEAQLAAGD-PRTVELKET---- 935 TPP + + PL +++ + GL+GS GD P EL ET Sbjct: 897 TPPFWGDRICKGIPLADYAAFLDERATFMGQWGLRGS------RGDGPTYEELVETEGRP 950 Query: 936 -VDEILHHAMLEGTMTPHAMYQFFPAQSKGNDILIYDPQDTATVLHTFTFPRQNVEPYLC 994 + L EG + P +Y ++ S+GND+++ + L FTFPRQ + +LC Sbjct: 951 RLRMWLDRIQTEGWLEPAVVYGYYRCYSEGNDLVVLGEDENE--LTRFTFPRQRRDRHLC 1008 Query: 995 LADFLKSVDSGIMDYVGFLVVTAGHGIREMSAELRDKG---DYLRSHXXXXXXXXXXXXX 1051 LADF + +SG +D V F VVT G I + +AEL +K DYL H Sbjct: 1009 LADFFRPKESGELDTVAFQVVTVGSTISKATAELFEKNAYRDYLELH---GLSVQLTEAL 1065 Query: 1052 XXXXHHMMRDTWGF----PDPADMTMKQRHGARYQGIRVSFGYPACPDLEDQGPLFKLMS 1107 H +R GF PDPAD+ + G Y+G R S GY ACP+LED+ + L+ Sbjct: 1066 AEYWHTRVRAELGFAGEDPDPADLDAYFKLG--YRGARFSLGYGACPNLEDRAKIVALLR 1123 Query: 1108 PGDIGVELTEGFMMEPEASVSAMVFAHPEAQYFNV 1142 P +GV L+E F + PE S A+V HPEA+YFNV Sbjct: 1124 PERVGVTLSEEFQLVPEQSTDAIVVHHPEAKYFNV 1158 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.317 0.136 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 1,592,677,075 Number of extensions: 66124764 Number of successful extensions: 175978 Number of sequences better than 1.0e-05: 801 Number of HSP's gapped: 173677 Number of HSP's successfully gapped: 902 Length of query: 1145 Length of database: 757,237,578 Length adjustment: 137 Effective length of query: 1008 Effective length of database: 385,269,015 Effective search space: 388351167120 Effective search space used: 388351167120 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 132 (55.5 bits)