BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0443.0007.p (197 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_390159.1| GTP cyclohydrolase I [Bacillus subtilis] >gi|12... 244 9e-64 ref|NP_242512.1| GTP cyclohydrolase I [Bacillus halodurans] >gi|... 243 1e-63 ref|ZP_00181507.1| hypothetical protein Mther043601 [Moorella th... 236 3e-61 ref|NP_655412.1| GTP_cyclohydroI, GTP cyclohydrolase I [Bacillus... 234 6e-61 emb|CAC39312.1| GTP Cyclohydrolase [Streptococcus pyogenes] 231 9e-60 >ref|NP_390159.1| GTP cyclohydrolase I [Bacillus subtilis] sp|P19465|GCH1_BACSU GTP cyclohydrolase I (GTP-CH-I) pir||A38256 GTP cyclohydrolase I (EC 3.5.4.16) mtrA - Bacillus subtilis gb|AAA22615.1| regulatory protein gb|AAA20852.1| MtrA [Bacillus subtilis] emb|CAB14194.1| GTP cyclohydrolase I [Bacillus subtilis subsp. subtilis str. 168] Length = 190 Score = 244 bits (622), Expect = 9e-64, Method: Compositional matrix adjust. Identities = 114/183 (62%), Positives = 143/183 (78%), Gaps = 1/183 (0%) Query: 15 NREQIEYHVEKILQLIGEDPGREGLLETPARVTRMYEEIFGGYSIDPREALGVTFDESHE 74 N+EQIE V +IL+ IGEDP REGLL+TP RV +MY E+F G + DP+E F E+HE Sbjct: 5 NKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVFSGLNEDPKEHFQTIFGENHE 64 Query: 75 ELVIVKDIVYYSQCEHHMAPFFGKVHIGYIP-SGRIAGLSKLARLVEAVSRRLQVQERIT 133 ELV+VKDI ++S CEHH+ PF+GK H+ YIP G++ GLSKLAR VEAV++R Q+QERIT Sbjct: 65 ELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTGLSKLARAVEAVAKRPQLQERIT 124 Query: 134 AQIADIMTEVLNPHGVMVVVEGEHLCMCARGVKKPGSKTVTMAARGTFREDAAARAEFLA 193 + IA+ + E L+PHGVMVVVE EH+CM RGV+KPG+KTVT A RG F++DAAARAE L Sbjct: 125 STIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPGAKTVTSAVRGVFKDDAAARAEVLE 184 Query: 194 LIK 196 IK Sbjct: 185 HIK 187 >ref|NP_242512.1| GTP cyclohydrolase I [Bacillus halodurans] sp|Q9KCC7|GCH1_BACHD GTP cyclohydrolase I (GTP-CH-I) pir||F83855 GTP cyclohydrolase I mtrA [imported] - Bacillus halodurans (strain C-125) dbj|BAB05365.1| GTP cyclohydrolase I [Bacillus halodurans] Length = 188 Score = 243 bits (621), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 115/183 (62%), Positives = 140/183 (76%), Gaps = 1/183 (0%) Query: 15 NREQIEYHVEKILQLIGEDPGREGLLETPARVTRMYEEIFGGYSIDPREALGVTFDESHE 74 + E+I+ V IL+ IGEDP REGL +TP RV +MYEE+F G + DP+E F E HE Sbjct: 5 DHEKIQQAVVMILEAIGEDPAREGLEDTPKRVAKMYEEVFAGLNQDPKEHFATIFGEDHE 64 Query: 75 ELVIVKDIVYYSQCEHHMAPFFGKVHIGYIPSG-RIAGLSKLARLVEAVSRRLQVQERIT 133 ELV+VKDI ++S CEHH+ PFFGK H+GYIP G ++ GLSKLAR VEAV+RR Q+QERIT Sbjct: 65 ELVLVKDIPFFSMCEHHLVPFFGKAHVGYIPKGGKVTGLSKLARAVEAVARRPQLQERIT 124 Query: 134 AQIADIMTEVLNPHGVMVVVEGEHLCMCARGVKKPGSKTVTMAARGTFREDAAARAEFLA 193 + +AD + E L PHGV+VVVE EH+CM RGVKKPG+ TVT A RGTF DAAARAE L+ Sbjct: 125 STVADALVETLEPHGVIVVVEAEHMCMTMRGVKKPGAATVTSAVRGTFANDAAARAEVLS 184 Query: 194 LIK 196 LIK Sbjct: 185 LIK 187 >ref|ZP_00181507.1| hypothetical protein Mther043601 [Moorella thermoacetica ATCC 39073] Length = 185 Score = 236 bits (601), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 111/182 (60%), Positives = 138/182 (75%) Query: 15 NREQIEYHVEKILQLIGEDPGREGLLETPARVTRMYEEIFGGYSIDPREALGVTFDESHE 74 ++E+I V I++ +GEDP REGL ETP R+ MYEEIF G + DP E L V FDE HE Sbjct: 2 DKEKIRQAVRMIIEAVGEDPDREGLRETPRRIADMYEEIFAGINRDPGEELTVVFDEHHE 61 Query: 75 ELVIVKDIVYYSQCEHHMAPFFGKVHIGYIPSGRIAGLSKLARLVEAVSRRLQVQERITA 134 E+V+VKDI YS CEHH PF G+ H+ YIP G+I GLSKLAR+V+ +RR QVQER+T+ Sbjct: 62 EMVLVKDIPLYSICEHHFLPFLGRAHVAYIPRGKITGLSKLARVVDIAARRPQVQERLTS 121 Query: 135 QIADIMTEVLNPHGVMVVVEGEHLCMCARGVKKPGSKTVTMAARGTFREDAAARAEFLAL 194 QIADI+ E LNP+GV+VV+E EHLCM RG+KKPGS T+T A RG FR D AARAE ++L Sbjct: 122 QIADIIMEKLNPYGVVVVIEAEHLCMSMRGIKKPGSLTITSAVRGLFRRDQAARAEAMSL 181 Query: 195 IK 196 I+ Sbjct: 182 IQ 183 >ref|NP_655412.1| GTP_cyclohydroI, GTP cyclohydrolase I [Bacillus anthracis A2012] ref|NP_831290.1| GTP cyclohydrolase I [Bacillus cereus ATCC 14579] ref|NP_843983.1| GTP cyclohydrolase I [Bacillus anthracis str. Ames] ref|NP_977959.1| GTP cyclohydrolase I [Bacillus cereus ATCC 10987] sp|Q81FQ8|GCH1_BACCR GTP cyclohydrolase I (GTP-CH-I) sp|Q81SW2|GCH1_BACAA GTP cyclohydrolase I (GTP-CH-I) gb|AAP08491.1| GTP cyclohydrolase I [Bacillus cereus ATCC 14579] gb|AAP25469.1| GTP cyclohydrolase I [Bacillus anthracis str. Ames] gb|AAS40567.1| GTP cyclohydrolase I [Bacillus cereus ATCC 10987] Length = 189 Score = 234 bits (598), Expect = 6e-61, Method: Compositional matrix adjust. Identities = 110/183 (60%), Positives = 137/183 (74%), Gaps = 1/183 (0%) Query: 15 NREQIEYHVEKILQLIGEDPGREGLLETPARVTRMYEEIFGGYSIDPREALGVTFDESHE 74 N EQIE+ V IL+ IG+DP REG+L+TP RV +MY E+F G DP+E L F E HE Sbjct: 5 NLEQIEHAVRLILEAIGDDPNREGVLDTPKRVAKMYAEVFSGMHEDPKEHLHKVFGEDHE 64 Query: 75 ELVIVKDIVYYSQCEHHMAPFFGKVHIGYIPS-GRIAGLSKLARLVEAVSRRLQVQERIT 133 ELV+VKDI +YS CEHH+ PF+G H+ YIP G++ GLSKLAR V+ ++RR Q+QERIT Sbjct: 65 ELVLVKDIPFYSMCEHHLVPFYGVAHVAYIPQGGKVTGLSKLARTVDTIARRPQLQERIT 124 Query: 134 AQIADIMTEVLNPHGVMVVVEGEHLCMCARGVKKPGSKTVTMAARGTFREDAAARAEFLA 193 + +A+ + EVL PHGVMVVVE EH+CM RGVKKPG+KTVT A RG DAAAR+E L+ Sbjct: 125 STVANSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPGAKTVTTAVRGVLENDAAARSEILS 184 Query: 194 LIK 196 IK Sbjct: 185 FIK 187 >emb|CAC39312.1| GTP Cyclohydrolase [Streptococcus pyogenes] Length = 202 Score = 231 bits (588), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 104/185 (56%), Positives = 139/185 (75%), Gaps = 1/185 (0%) Query: 12 VAANREQIEYHVEKILQLIGEDPGREGLLETPARVTRMYEEIFGGYSIDPREALGVTFDE 71 ++ N+E+ E + + L+ IGE+P REGLL+TP RV +MY E+F G + DP+E F E Sbjct: 15 MSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFAGLNKDPKEEFTAVFTE 74 Query: 72 SHEELVIVKDIVYYSQCEHHMAPFFGKVHIGYIPS-GRIAGLSKLARLVEAVSRRLQVQE 130 HE++VIVKDI +YS CEHH+ PF+GK HI Y+PS GR+ GLSKLAR VE S+R Q+QE Sbjct: 75 HHEDVVIVKDISFYSMCEHHLVPFYGKAHIAYLPSDGRVTGLSKLARAVEVASKRPQLQE 134 Query: 131 RITAQIADIMTEVLNPHGVMVVVEGEHLCMCARGVKKPGSKTVTMAARGTFREDAAARAE 190 R+TAQIAD + E L+P GV+V+VE EH+CM RG+KKPGSKT+T ARG ++ED + R E Sbjct: 135 RLTAQIADALVEALHPTGVLVLVEAEHMCMTMRGIKKPGSKTITTTARGLYKEDRSERQE 194 Query: 191 FLALI 195 +AL+ Sbjct: 195 VMALM 199 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.321 0.137 0.394 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 280,291,383 Number of extensions: 10864010 Number of successful extensions: 26008 Number of sequences better than 1.0e-05: 657 Number of HSP's gapped: 25472 Number of HSP's successfully gapped: 661 Length of query: 197 Length of database: 757,237,578 Length adjustment: 119 Effective length of query: 78 Effective length of database: 434,140,797 Effective search space: 33862982166 Effective search space used: 33862982166 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 122 (51.6 bits)