BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0437.0035.p (202 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_603370.1| Regulatory protein betI [Fusobacterium nucleatu... 79 6e-14 ref|NP_970862.1| transcriptional regulator, TetR family [Trepone... 72 7e-12 ref|NP_809420.1| transcriptional regulator (TetR/AcrR family) [B... 70 4e-11 ref|NP_811395.1| transcriptional regulator [Bacteroides thetaiot... 64 2e-09 ref|NP_105601.1| transcriptional regulator (TetR family) [Mesorh... 57 3e-07 >ref|NP_603370.1| Regulatory protein betI [Fusobacterium nucleatum subsp. nucleatum ATCC 25586] gb|AAL94669.1| Regulatory protein betI [Fusobacterium nucleatum subsp. nucleatum ATCC 25586] Length = 189 Score = 79.0 bits (193), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 51/145 (35%), Positives = 83/145 (57%), Gaps = 15/145 (10%) Query: 2 QAKKDEVKRDIESAALKVFFRKGFADAKMNDIADEIQISVGNIYTYFKNKQELFYAVVPP 61 Q K+E+K I AA K+F+ KGF KM DI++E +I VG +YTY+KNK+ELF +V P Sbjct: 3 QILKEEIKNRIYKAASKIFYEKGFLKTKMKDISEEAKIPVGLVYTYYKNKEELFDEIVNP 62 Query: 62 SLVDYLKNVLVESIRLDNQTFFDRAGSDKQSAIVQEQMNLLTQYSMQIVIIFEKNKGTVY 121 + Y N+ +E + + +R + + +++ LL Q+ +VI+ +K +GT + Sbjct: 63 --IYYYLNLAIEKEEKEEGSALERFKATGEEYVLK----LLNQHK-SLVILMDKAQGTKH 115 Query: 122 SNAKNELIELMIETKKPFLKDHYKR 146 NAK I++ L++H KR Sbjct: 116 ENAKQVFIKI--------LENHIKR 132 >ref|NP_970862.1| transcriptional regulator, TetR family [Treponema denticola ATCC 35405] gb|AAS10743.1| transcriptional regulator, TetR family [Treponema denticola ATCC 35405] Length = 189 Score = 72.0 bits (175), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 48/147 (32%), Positives = 85/147 (57%), Gaps = 10/147 (6%) Query: 1 MQAKKDEVKRDIESAALKVFFRKGFADAKMNDIADEIQISVGNIYTYFKNKQELFYAVVP 60 MQ K+EVK I +AA KVF+ + + AK+ DIA++ I V IYTYFKNK+ LF VV Sbjct: 1 MQVLKEEVKDRILTAAEKVFYEQDYRSAKLTDIAEQADIPVALIYTYFKNKEGLFDEVV- 59 Query: 61 PSLVDYLKNVLVESIRLDNQTFFDRAGSDKQSAIVQEQMNLLTQYSMQIVIIFEKNKGTV 120 ++D + ++ + +++ + ++R S Q+ L + ++++I+ +K+ GT Sbjct: 60 AGVLDKIIKMMEDEEKMEAGSPYERFNRGGAS-----QLPKLLKNRIKLIILIDKSSGTK 114 Query: 121 YSNAKNELIELMIETKKPFLKDHYKRY 147 + NAK+ + ++ + +KD KRY Sbjct: 115 HENAKD----MWVKRLEQHIKDGLKRY 137 >ref|NP_809420.1| transcriptional regulator (TetR/AcrR family) [Bacteroides thetaiotaomicron VPI-5482] gb|AAO75614.1| transcriptional regulator (TetR/AcrR family) [Bacteroides thetaiotaomicron VPI-5482] Length = 202 Score = 69.7 bits (169), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 48/154 (31%), Positives = 81/154 (52%), Gaps = 7/154 (4%) Query: 1 MQAKKDEVKRDIESAALKVFFRKGFADAKMNDIADEIQISVGNIYTYFKNKQELFYAVVP 60 MQ K++++ I A +VF KG+ DA M +IA I+V NIY YF NK E+F ++ Sbjct: 1 MQYLKEDIQEKILHIAEEVFSEKGYKDASMREIASRTGITVSNIYHYFTNKDEIFRTILK 60 Query: 61 PSLVD-YLKNVLVESIRLDNQTFFDRAGSDKQSAIVQEQMNLLTQYSMQIVIIFEKNKGT 119 P L D Y K ++ ++ + F SD Q VQE ++L++++ ++ ++ + +G+ Sbjct: 61 PVLNDLYAKIYSHDANQMSIEVF---TNSDYQQESVQEYIDLVSEHRARLRMLLFQAQGS 117 Query: 120 VYSNAKNELIELMIETKKPF---LKDHYKRYEIG 150 N ++E + M T F +K Y IG Sbjct: 118 SLENFRSEYTDAMTRTIFVFFQGMKQKYPHLNIG 151 >ref|NP_811395.1| transcriptional regulator [Bacteroides thetaiotaomicron VPI-5482] gb|AAO77589.1| transcriptional regulator [Bacteroides thetaiotaomicron VPI-5482] Length = 129 Score = 63.9 bits (154), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 29/61 (47%), Positives = 40/61 (65%) Query: 1 MQAKKDEVKRDIESAALKVFFRKGFADAKMNDIADEIQISVGNIYTYFKNKQELFYAVVP 60 MQ KD+++++I AA KVF GF A M +IA E Q+ + NIY YFK+K ++F VV Sbjct: 20 MQYSKDDIQKEILKAAEKVFLENGFPKASMREIAQEAQVGLSNIYNYFKSKDDIFCTVVR 79 Query: 61 P 61 P Sbjct: 80 P 80 >ref|NP_105601.1| transcriptional regulator (TetR family) [Mesorhizobium loti MAFF303099] dbj|BAB51387.1| transcriptional regulator (TetR family) [Mesorhizobium loti] Length = 244 Score = 56.6 bits (135), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 32/69 (46%), Positives = 39/69 (56%), Gaps = 1/69 (1%) Query: 3 AKKDEVKRD-IESAALKVFFRKGFADAKMNDIADEIQISVGNIYTYFKNKQELFYAVVPP 61 A +D VKR I A +VF KGF A MNDI E +S G IY YF NK+ELF A++ Sbjct: 27 AGQDPVKRSQIIDGARRVFIEKGFEAASMNDITREAGVSKGTIYVYFANKEELFEALIEE 86 Query: 62 SLVDYLKNV 70 KN+ Sbjct: 87 ERGTIFKNM 95 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.319 0.135 0.373 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 244,790,252 Number of extensions: 8563639 Number of successful extensions: 27252 Number of sequences better than 1.0e-05: 22 Number of HSP's gapped: 27271 Number of HSP's successfully gapped: 22 Length of query: 202 Length of database: 757,237,578 Length adjustment: 120 Effective length of query: 82 Effective length of database: 431,425,698 Effective search space: 35376907236 Effective search space used: 35376907236 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 123 (52.0 bits)