BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0435.0012.p (195 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_600273.1| aldo/keto reductase [Corynebacterium glutamicum... 264 1e-69 dbj|BAB98441.1| Aldo/keto reductases, related to diketogulonate ... 262 3e-69 ref|NP_687463.1| oxidoreductase, aldo/keto reductase family [Str... 252 3e-66 ref|NP_861002.1| aldo-keto reductase [Helicobacter hepaticus ATC... 244 6e-64 gb|AAG09967.1| aldose reductase [Streptococcus agalactiae] 238 8e-62 >ref|NP_600273.1| aldo/keto reductase [Corynebacterium glutamicum ATCC 13032] emb|CAF19752.1| Aldo/keto reductase [Corynebacterium glutamicum ATCC 13032] Length = 267 Score = 264 bits (674), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 122/195 (62%), Positives = 153/195 (78%), Gaps = 1/195 (0%) Query: 1 VRDAVSIGYRHIDTAQAYGNEAGVGEAIRICGIAREELFITTKVAAELKKFDAVTQSIDE 60 VR A+ GYR+IDTA AYGNE GVGE IR G+ REELFI+TK+AAE+K +D +IDE Sbjct: 17 VRAAIVAGYRNIDTALAYGNERGVGEGIRTAGVPREELFISTKLAAEIKDYDGAVAAIDE 76 Query: 61 SLAKLGLEYIDLLIIHSPQPWKEFRGENRYFEENKEVWKAMEAAYKAGKVKAIGLSNFLE 120 SLAK+GL+Y+DL++IHSPQPW +FRG + Y E N+E W+A+E AYKAGK+++IG+SNFLE Sbjct: 77 SLAKIGLDYVDLMLIHSPQPWSDFRGGD-YSEGNREAWRALEDAYKAGKIRSIGVSNFLE 135 Query: 121 DDVEDILSSCEVKPMVNQILAHVSNTPMPLIEFCRKHDILVEAYSPIVHGAILDHAEVKA 180 D+E+IL S V P VNQ+L HV NTP LI FC ILVEAYSPI HG +L + +VKA Sbjct: 136 ADLENILDSATVAPHVNQLLVHVGNTPSELISFCDSKGILVEAYSPIAHGEMLKNQQVKA 195 Query: 181 IADQYGVSVAQLCLR 195 IAD+Y VS+ QLC+R Sbjct: 196 IADKYNVSIPQLCIR 210 >dbj|BAB98441.1| Aldo/keto reductases, related to diketogulonate reductase [Corynebacterium glutamicum ATCC 13032] Length = 281 Score = 262 bits (669), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 122/195 (62%), Positives = 153/195 (78%), Gaps = 1/195 (0%) Query: 1 VRDAVSIGYRHIDTAQAYGNEAGVGEAIRICGIAREELFITTKVAAELKKFDAVTQSIDE 60 VR A+ GYR+IDTA AYGNE GVGE IR G+ REELFI+TK+AAE+K +D +IDE Sbjct: 31 VRAAIVAGYRNIDTALAYGNERGVGEGIRTAGVPREELFISTKLAAEIKDYDGAVAAIDE 90 Query: 61 SLAKLGLEYIDLLIIHSPQPWKEFRGENRYFEENKEVWKAMEAAYKAGKVKAIGLSNFLE 120 SLAK+GL+Y+DL++IHSPQPW +FRG + Y E N+E W+A+E AYKAGK+++IG+SNFLE Sbjct: 91 SLAKIGLDYVDLMLIHSPQPWSDFRGGD-YSEGNREAWRALEDAYKAGKIRSIGVSNFLE 149 Query: 121 DDVEDILSSCEVKPMVNQILAHVSNTPMPLIEFCRKHDILVEAYSPIVHGAILDHAEVKA 180 D+E+IL S V P VNQ+L HV NTP LI FC ILVEAYSPI HG +L + +VKA Sbjct: 150 ADLENILDSATVAPHVNQLLVHVGNTPSELISFCDSKGILVEAYSPIAHGEMLKNQQVKA 209 Query: 181 IADQYGVSVAQLCLR 195 IAD+Y VS+ QLC+R Sbjct: 210 IADKYNVSIPQLCIR 224 >ref|NP_687463.1| oxidoreductase, aldo/keto reductase family [Streptococcus agalactiae 2603V/R] gb|AAM99335.1| oxidoreductase, aldo/keto reductase family [Streptococcus agalactiae 2603V/R] Length = 284 Score = 252 bits (644), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 116/196 (59%), Positives = 155/196 (79%), Gaps = 1/196 (0%) Query: 1 VRDAVSIGYRHIDTAQAYGNEAGVGEAIRICGIAREELFITTKVAAELKKFDAVTQSIDE 60 V+DA+ +GYRHIDTAQAY NE GVG I+ GI RE LF+TTK+AAE K +++ T+SID+ Sbjct: 32 VKDAIELGYRHIDTAQAYNNEKGVGVGIKESGITRESLFVTTKIAAEHKDYESATKSIDQ 91 Query: 61 SLAKLGLEYIDLLIIHSPQPWKEFRGENRYFEE-NKEVWKAMEAAYKAGKVKAIGLSNFL 119 SL LGL+YIDL+IIHSPQPWKE+R +++F++ N E W+A+E A K+GK+K+IG+SNFL Sbjct: 92 SLEALGLDYIDLMIIHSPQPWKEWRETDKHFDQGNLEAWRALEDAQKSGKMKSIGVSNFL 151 Query: 120 EDDVEDILSSCEVKPMVNQILAHVSNTPMPLIEFCRKHDILVEAYSPIVHGAILDHAEVK 179 E D+E+IL + VKP VNQILAH+ NTP LI++C+ I VEAYSPI HG L ++ Sbjct: 152 EKDLENILKNGHVKPAVNQILAHIGNTPFDLIDYCQSKGIQVEAYSPIAHGQALKSDGIQ 211 Query: 180 AIADQYGVSVAQLCLR 195 +A++YGVSVAQLC++ Sbjct: 212 KMAEKYGVSVAQLCIQ 227 >ref|NP_861002.1| aldo-keto reductase [Helicobacter hepaticus ATCC 51449] gb|AAP78068.1| aldo-keto reductase [Helicobacter hepaticus ATCC 51449] Length = 292 Score = 244 bits (624), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 111/195 (56%), Positives = 147/195 (75%), Gaps = 1/195 (0%) Query: 1 VRDAVSIGYRHIDTAQAYGNEAGVGEAIRICGIAREELFITTKVAAELKKFDAVTQSIDE 60 VR+A +GYRHIDTAQAYGNE GVGEA+R I REELFIT+K+ AE K + + + SID Sbjct: 42 VREAFKVGYRHIDTAQAYGNERGVGEAVRKSKIKREELFITSKIRAEYKDYKSASASIDT 101 Query: 61 SLAKLGLEYIDLLIIHSPQPWKEFRGENRYFEENKEVWKAMEAAYKAGKVKAIGLSNFLE 120 SL + L++IDL++IHSPQPW FR + YF+EN EV+ A+E A KAGKV++IG+SNFL+ Sbjct: 102 SLKTMKLDFIDLMLIHSPQPWNSFR-KGDYFKENVEVYNALEDAQKAGKVRSIGVSNFLQ 160 Query: 121 DDVEDILSSCEVKPMVNQILAHVSNTPMPLIEFCRKHDILVEAYSPIVHGAILDHAEVKA 180 D+E+IL +C+ KP NQIL H+ NTP L+++C+K +IL EAYSPI HG +L V Sbjct: 161 KDLENILKNCKTKPAANQILCHIGNTPFTLLDYCKKQNILAEAYSPIAHGELLKDPRVIE 220 Query: 181 IADQYGVSVAQLCLR 195 +A +Y VS AQ+C+R Sbjct: 221 LAKKYNVSPAQICIR 235 >gb|AAG09967.1| aldose reductase [Streptococcus agalactiae] Length = 280 Score = 238 bits (606), Expect = 8e-62, Method: Compositional matrix adjust. Identities = 113/196 (57%), Positives = 150/196 (76%), Gaps = 5/196 (2%) Query: 1 VRDAVSIGYRHIDTAQAYGNEAGVGEAIRICGIAREELFITTKVAAELKKFDAVTQSIDE 60 V+DA+ +GYRHI+TAQAY NE GVG I+ GI RE LF+TTK+AAE K +++ T+SID+ Sbjct: 32 VKDAIELGYRHINTAQAYNNEKGVGVGIKESGITRESLFVTTKIAAEHKDYESATKSIDQ 91 Query: 61 SLAKLGLEYIDLLIIHSPQPWKEFRGENRYFEE-NKEVWKAMEAAYKAGKVKAIGLSNFL 119 SL LGL+ IDL+IIHSPQPWKE+R +++F++ N E W+A+E A K+GKVK+IG+SNFL Sbjct: 92 SLEALGLDCIDLMIIHSPQPWKEWRETDKHFDQGNLEAWRALEDAQKSGKVKSIGVSNFL 151 Query: 120 EDDVEDILSSCEVKPMVNQILAHVSNTPMPLIEFCRKHDILVEAYSPIVHGAILDHAEVK 179 E D L + VKP VNQILAH+ NTP LI++C+ I VEAYSPI HG L ++ Sbjct: 152 EKD----LKNGHVKPAVNQILAHIGNTPFDLIDYCQSKGIQVEAYSPIAHGQALKSDGIQ 207 Query: 180 AIADQYGVSVAQLCLR 195 +A++YGVSVAQLC++ Sbjct: 208 KMAEKYGVSVAQLCIQ 223 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.319 0.136 0.393 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 277,406,715 Number of extensions: 10829587 Number of successful extensions: 36339 Number of sequences better than 1.0e-05: 975 Number of HSP's gapped: 34974 Number of HSP's successfully gapped: 981 Length of query: 195 Length of database: 757,237,578 Length adjustment: 119 Effective length of query: 76 Effective length of database: 434,140,797 Effective search space: 32994700572 Effective search space used: 32994700572 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 122 (51.6 bits)