BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0435.0003.p (335 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|ZP_00032809.1| COG0667: Predicted oxidoreductases (related t... 450 e-125 ref|NP_822773.1| putative aldo/keto reductase [Streptomyces aver... 429 e-119 ref|NP_471447.1| similar to oxidoreductase [Listeria innocua] >g... 425 e-118 ref|NP_465529.1| similar to oxidoreductase [Listeria monocytogen... 424 e-117 ref|NP_733514.1| putative aldo/keto reductase; putative oxidored... 413 e-114 >ref|ZP_00032809.1| COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Burkholderia fungorum] Length = 390 Score = 450 bits (1157), Expect = e-125, Method: Compositional matrix adjust. Identities = 217/327 (66%), Positives = 257/327 (78%), Gaps = 5/327 (1%) Query: 9 MDYTKLGNTGLDVSRICLGCMGFGDPDKGHHRWVLDEKSARPIIQKALDIGINFFDTANV 68 MDY KLG TGLDVSR+CLGCM +G P +G H W L +++ARP I++ALD GINFFDTANV Sbjct: 65 MDYVKLGRTGLDVSRLCLGCMSYGVPSRGPHPWTLGDEAARPFIKQALDHGINFFDTANV 124 Query: 69 YAEGTSEEIVGNVLKELADRDEIVIATKIHGRMHQGPNGAGLSRKAIMSEIDKSLKRLKT 128 Y++GTSEEIVG LK+ A RDEIV+ATK+HGRMH GPNGAGLSRK IM+EID SL+RL T Sbjct: 125 YSDGTSEEIVGRALKDFAMRDEIVLATKVHGRMHPGPNGAGLSRKVIMAEIDNSLRRLGT 184 Query: 129 DYVDLYQIHRWDYNTPIEETIEALHDVVKAGKARYIGXXXXSAMWAWQFQKALHAAEKNG 188 DYVDLYQIHRWDY TPIEET+EALHDVVKAGKARYIG S+M+AWQF KALH AE+NG Sbjct: 185 DYVDLYQIHRWDYGTPIEETMEALHDVVKAGKARYIG---ASSMYAWQFAKALHVAERNG 241 Query: 189 WTRFVSMQNHLNLIYREEEREMLPLCKEEKIGVIPYSPLAGGRLAREAST--PRAETDEI 246 WTRF +MQN++NL+YREEEREMLPLC+ E IGVIP+SPLA GRL R+ +T R+ETDE Sbjct: 242 WTRFATMQNYVNLLYREEEREMLPLCESEGIGVIPWSPLARGRLTRDWNTGSARSETDEF 301 Query: 247 AKQKYXXXXXXXXXXXXXXXNLAEKHGVRRVHIALAWLLHKEPVTAPIVGATKITQLEDA 306 + Y +A++ GV R +ALAW+L K+P+TAPIVGATK+ L+DA Sbjct: 302 GRTLYAQTEDADRRIVERVSEIAKERGVPRAQVALAWVLQKKPITAPIVGATKLHHLDDA 361 Query: 307 EAALSLKLTQEEISFLEEPYVPHRVVG 333 AALSL L+ +EI LEE YVPH V G Sbjct: 362 VAALSLNLSADEIGRLEELYVPHAVTG 388 >ref|NP_822773.1| putative aldo/keto reductase [Streptomyces avermitilis MA-4680] dbj|BAC69308.1| putative aldo/keto reductase [Streptomyces avermitilis MA-4680] Length = 322 Score = 429 bits (1104), Expect = e-119, Method: Compositional matrix adjust. Identities = 206/328 (62%), Positives = 253/328 (77%), Gaps = 8/328 (2%) Query: 9 MDYTKLGNTGLDVSRICLGCMGFGDPDKGHHRWVLDEKSARPIIQKALDIGINFFDTANV 68 M + KLG+TGLDVSRIC+GCM FG PD+G H W LDE+++RP+I++AL+ GINFFDTANV Sbjct: 1 MQFVKLGSTGLDVSRICVGCMSFGLPDRGPHEWTLDEEASRPLIRQALEAGINFFDTANV 60 Query: 69 YAEGTSEEIVGNVLKELADRDEIVIATKIHGRMHQGPNGAGLSRKAIMSEIDKSLKRLKT 128 Y++GTSEEIVG L + A R+EIV+ATK++G MH+GPNG GLSRKAIM+EID SL+RL T Sbjct: 61 YSDGTSEEIVGRALADFARREEIVLATKVNGSMHEGPNGHGLSRKAIMTEIDNSLRRLGT 120 Query: 129 DYVDLYQIHRWDYNTPIEETIEALHDVVKAGKARYIGXXXXSAMWAWQFQKALHAAEKNG 188 DYVDLYQIHRWD TP+EET+EALHDVVKAGKARY+G S+M+AWQF KA + A NG Sbjct: 121 DYVDLYQIHRWDPTTPVEETMEALHDVVKAGKARYVG---ASSMYAWQFSKAQYTARLNG 177 Query: 189 WTRFVSMQNHLNLIYREEEREMLPLCKEEKIGVIPYSPLAGGRLA--REASTPRAETDEI 246 WTRFVSMQNH NL+YREEEREMLPLC+++ +GV+P+SPLA GRL R+ +T R+ TDE Sbjct: 178 WTRFVSMQNHYNLLYREEEREMLPLCEDQGVGVLPWSPLARGRLTRDRDVTTARSRTDEF 237 Query: 247 AKQKYXXXXXXXXXXXXXXXNLAEKHGVRRVHIALAWLLHKEPVTAPIVGATKITQLEDA 306 K Y +A GV R +ALAWLLH+ VTAPIVGATK L+DA Sbjct: 238 GKTLY---RQGDDEIVDAVARIAADRGVPRARVALAWLLHQRAVTAPIVGATKPAHLDDA 294 Query: 307 EAALSLKLTQEEISFLEEPYVPHRVVGH 334 AAL L+L+++EI LE+PYVP + GH Sbjct: 295 VAALDLELSEKEIEQLEQPYVPRAISGH 322 >ref|NP_471447.1| similar to oxidoreductase [Listeria innocua] pir||AG1696 oxidoreductase homolog lin2113 [imported] - Listeria innocua (strain Clip11262) emb|CAC97343.1| lin2113 [Listeria innocua] Length = 331 Score = 425 bits (1092), Expect = e-118, Method: Compositional matrix adjust. Identities = 208/328 (63%), Positives = 252/328 (76%), Gaps = 6/328 (1%) Query: 9 MDYTKLGNTGLDVSRICLGCMGFGDPDKGHHRWVLDEKSARPIIQKALDIGINFFDTANV 68 M+Y K GNTG+DVS+ICLG MGFGD DK H+WVLDE ++RPII+KALD+GINFFDTAN+ Sbjct: 1 MEYVKFGNTGMDVSKICLGTMGFGDKDKWIHKWVLDEANSRPIIKKALDLGINFFDTANI 60 Query: 69 YAEGTSEEIVGNVLKELADRDEIVIATKIHGRMHQG-PNGAGLSRKAIMSEIDKSLKRLK 127 Y+ G SE+IVG LK+ A+RD+IV+ATKIH M PN GLSRK I+SEID SLKRL+ Sbjct: 61 YSYGESEKIVGRALKDYANRDDIVLATKIHQTMRPDRPNSGGLSRKTILSEIDHSLKRLE 120 Query: 128 TDYVDLYQIHRWDYNTPIEETIEALHDVVKAGKARYIGXXXXSAMWAWQFQKALHAAEKN 187 TDYVDLY IHR+D NTPIEET+EALHDVVK+GKARYIG SAM+AWQFQKA AE+N Sbjct: 121 TDYVDLYIIHRFDENTPIEETMEALHDVVKSGKARYIG---ASAMYAWQFQKAQRVAERN 177 Query: 188 GWTRFVSMQNHLNLIYREEEREMLPLCKEEKIGVIPYSPLAGGRLARE--ASTPRAETDE 245 GWT+FVSMQNH N+IYREEEREM+P C++EKI + PYSPLA GRL R+ +T R+ETD Sbjct: 178 GWTKFVSMQNHYNMIYREEEREMIPFCRDEKIAITPYSPLASGRLTRDFAETTNRSETDP 237 Query: 246 IAKQKYXXXXXXXXXXXXXXXNLAEKHGVRRVHIALAWLLHKEPVTAPIVGATKITQLED 305 I K KY LA +H V R IALAWLL+K+ +T+PI+GA K + LE Sbjct: 238 IQKSKYDGMMNSDKGIIERVAELALEHEVSRDKIALAWLLNKDEITSPIIGAQKESHLES 297 Query: 306 AEAALSLKLTQEEISFLEEPYVPHRVVG 333 A AL +KLT+ E+++LEE Y+PH VVG Sbjct: 298 AIGALDIKLTEAEVNYLEELYIPHPVVG 325 >ref|NP_465529.1| similar to oxidoreductase [Listeria monocytogenes EGD-e] pir||AE1325 oxidoreductase homolog lmo2005 [imported] - Listeria monocytogenes (strain EGD-e) emb|CAD00083.1| lmo2005 [Listeria monocytogenes] Length = 331 Score = 424 bits (1091), Expect = e-117, Method: Compositional matrix adjust. Identities = 206/328 (62%), Positives = 250/328 (76%), Gaps = 6/328 (1%) Query: 9 MDYTKLGNTGLDVSRICLGCMGFGDPDKGHHRWVLDEKSARPIIQKALDIGINFFDTANV 68 M Y K GNTG+DVS+ICLG MGFGD DK H+WVLDE ++RPII+KALD+GINFFDTAN+ Sbjct: 1 MKYVKFGNTGMDVSKICLGTMGFGDKDKWIHKWVLDEANSRPIIKKALDLGINFFDTANI 60 Query: 69 YAEGTSEEIVGNVLKELADRDEIVIATKIHGRMHQG-PNGAGLSRKAIMSEIDKSLKRLK 127 Y+ G SE+IVG LK+ A+RD+IV+ATK+ M PN GLSRK I+SEID SLKRL+ Sbjct: 61 YSYGESEKIVGRALKDYANRDDIVLATKVQQTMRPDRPNSGGLSRKTILSEIDHSLKRLE 120 Query: 128 TDYVDLYQIHRWDYNTPIEETIEALHDVVKAGKARYIGXXXXSAMWAWQFQKALHAAEKN 187 TDYVDLY IHR+D NTPIEET+EALHDVVK+GKARYIG SAM+AWQFQKA AE+N Sbjct: 121 TDYVDLYIIHRFDENTPIEETMEALHDVVKSGKARYIG---ASAMYAWQFQKAQRVAERN 177 Query: 188 GWTRFVSMQNHLNLIYREEEREMLPLCKEEKIGVIPYSPLAGGRLARE--ASTPRAETDE 245 GWT+FVSMQNH N+IYREEEREM+P C++EKI + PYSPLA GRL R+ +T R+ETD Sbjct: 178 GWTKFVSMQNHYNMIYREEEREMIPFCRDEKIAITPYSPLASGRLTRDLNETTDRSETDP 237 Query: 246 IAKQKYXXXXXXXXXXXXXXXNLAEKHGVRRVHIALAWLLHKEPVTAPIVGATKITQLED 305 + K KY LAE H V R IALAWLL+K+ +T+PI+GA K + LE Sbjct: 238 VQKSKYDDMMNADKGIIERVAELAETHQVSRDKIALAWLLNKDEITSPIIGAQKESHLES 297 Query: 306 AEAALSLKLTQEEISFLEEPYVPHRVVG 333 A AL++KLT E+++LEE Y+PH VVG Sbjct: 298 AVEALNIKLTTSEVNYLEELYIPHPVVG 325 >ref|NP_733514.1| putative aldo/keto reductase; putative oxidoreductase (fragment) [Streptomyces coelicolor A3(2)] emb|CAD55277.1| putative aldo/keto reductase; putative oxidoreductase (fragment) [Streptomyces coelicolor A3(2)] Length = 322 Score = 413 bits (1061), Expect = e-114, Method: Compositional matrix adjust. Identities = 197/328 (60%), Positives = 248/328 (75%), Gaps = 8/328 (2%) Query: 9 MDYTKLGNTGLDVSRICLGCMGFGDPDKGHHRWVLDEKSARPIIQKALDIGINFFDTANV 68 M Y KLG+TGLDVSRICLGCM +G PD+G H W LDE ++RP+I++AL+ G+ FFDTANV Sbjct: 1 MQYVKLGSTGLDVSRICLGCMTYGVPDRGTHEWTLDEAASRPLIRQALEAGVTFFDTANV 60 Query: 69 YAEGTSEEIVGNVLKELADRDEIVIATKIHGRMHQGPNGAGLSRKAIMSEIDKSLKRLKT 128 Y++GTSEEIVG L + A RD+IV+ATK++GRM GPNGAGLSRKA+M+EID SL+RL T Sbjct: 61 YSDGTSEEIVGKALADFARRDDIVLATKVNGRMRPGPNGAGLSRKAVMTEIDHSLRRLGT 120 Query: 129 DYVDLYQIHRWDYNTPIEETIEALHDVVKAGKARYIGXXXXSAMWAWQFQKALHAAEKNG 188 DYVDLYQIHR+D +TP+EET+EALHD+VKAGK RYIG S+M+AWQF K + AE++G Sbjct: 121 DYVDLYQIHRFDPHTPVEETMEALHDLVKAGKVRYIG---ASSMYAWQFSKMQYTAERHG 177 Query: 189 WTRFVSMQNHLNLIYREEEREMLPLCKEEKIGVIPYSPLAGGRLAR--EASTPRAETDEI 246 WT+FVSMQNH NL+YREEEREMLPLC ++ +GV+P+SPLA GRL R + +T R+ TD Sbjct: 178 WTKFVSMQNHYNLVYREEEREMLPLCADQGVGVLPWSPLARGRLTRDWDTATGRSATDTF 237 Query: 247 AKQKYXXXXXXXXXXXXXXXNLAEKHGVRRVHIALAWLLHKEPVTAPIVGATKITQLEDA 306 Y +A + GV R +ALAWLLH++ VTAPIVGA++ LEDA Sbjct: 238 GSTLY---QEGDRAVVEAVTRIAGERGVPRARVALAWLLHQDTVTAPIVGASRPGHLEDA 294 Query: 307 EAALSLKLTQEEISFLEEPYVPHRVVGH 334 AA+ L L++ EI LE PY PH + GH Sbjct: 295 VAAVELTLSETEIEELERPYAPHPIAGH 322 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.318 0.135 0.402 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 472,890,440 Number of extensions: 18192467 Number of successful extensions: 48618 Number of sequences better than 1.0e-05: 1594 Number of HSP's gapped: 45231 Number of HSP's successfully gapped: 1599 Length of query: 335 Length of database: 757,237,578 Length adjustment: 126 Effective length of query: 209 Effective length of database: 415,135,104 Effective search space: 86763236736 Effective search space used: 86763236736 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 126 (53.1 bits)