BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0407.0020.p (463 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|ZP_00097929.1| COG1012: NAD-dependent aldehyde dehydrogenase... 489 e-137 ref|NP_646678.1| aldehyde dehydrogenase [Staphylococcus aureus s... 487 e-136 emb|CAA71129.1| aldehyde dehydrogenase [Staphylococcus aureus] 486 e-136 ref|NP_372444.1| aldehyde dehydrogenase [Staphylococcus aureus s... 485 e-136 ref|NP_765158.1| aldehyde dehydrogenase [Staphylococcus epidermi... 472 e-132 >ref|ZP_00097929.1| COG1012: NAD-dependent aldehyde dehydrogenases [Desulfitobacterium hafniense] Length = 456 Score = 489 bits (1258), Expect = e-137, Method: Compositional matrix adjust. Identities = 223/456 (48%), Positives = 322/456 (70%), Gaps = 2/456 (0%) Query: 8 NVEQMLEETREFFHTGATRAVAFRLEQLQKLKNAIKRCETQLITALKKDLRKSEFEAYAT 67 +++++L + + FF TG T+ + FR++ L KL++AIK E +++ ALK DL K+ FEAYAT Sbjct: 3 DIKEILVKQKAFFQTGKTKELQFRVDMLNKLRSAIKIHEEEIMAALKADLNKAPFEAYAT 62 Query: 68 EIGFTLDSIGYMMKHLKRWAKPVKVKSPLHMFPAKSLILSEPYGTVLVIGPFNYPFQLLI 127 E+G L+ + Y +KH+ W KP +V++PL FP+ S + +EPYG+VL++ P+NYPFQL + Sbjct: 63 EVGMVLEELNYTLKHISSWVKPKRVRTPLVHFPSASYLYTEPYGSVLIMSPWNYPFQLAL 122 Query: 128 EPLIGAIAAGNCAVLKPSESTPAVSGVIEDMIRETFEPAYIRVVQGEKEMTTLLIHTKFD 187 PL+GAI+AGNCAVLKPSE + S +IE +++E F+ +++ VV+G +E L++ KFD Sbjct: 123 APLVGAISAGNCAVLKPSEYSANTSAMIERIVKEIFDESFVAVVRGGREANKTLLNEKFD 182 Query: 188 YIFFTGSVPVGKIVMEAAAKNLVPVTLELGGKSPVIVDKTADLESAAKRIVWGKLINAGQ 247 YIFFTGSV VGK VME+AA++L PVTLELGGKSP I+D TADLE AAKRIVWGK +NAGQ Sbjct: 183 YIFFTGSVGVGKTVMESAARHLTPVTLELGGKSPCIIDDTADLELAAKRIVWGKFLNAGQ 242 Query: 248 TCIAPDYLLVHSEIAAELIRRIKHYVTVFYGSDSQRSPDYGRIVNERQLQRIRGMLEKDQ 307 TC+APDYLLVH + +LI+ IK +T FYG D + DY +I+N++ +R+ G+L+ Sbjct: 243 TCVAPDYLLVHRTVKEKLIQEIKKSITAFYGHDPLGNEDYPKIINQKHFERLLGLLK--S 300 Query: 308 AKIILGGRVLAEDLYIEPTLIHPAAWSDASMADEIFGPVLPIMEYSRLEEAIQSVNEHPK 367 +++ GGR + I PT++ W M +EIFGP+LP++E+ + A+ VN+HPK Sbjct: 301 GRVVEGGRSDEKTRRIAPTILDDVTWESPVMQEEIFGPLLPVLEFESFDAALAMVNQHPK 360 Query: 368 PLALYLFTEDKQVEQEVLGRVSFGGGCVNDTITHVASTHLPFXXXXXXXXXXXXXRHSFD 427 PLALYLFT K E + + + SFGGGC+NDTI H+A+ +L F + S+D Sbjct: 361 PLALYLFTRSKDHEAQAISKTSFGGGCINDTIIHLANPNLRFGGVGESGMGQYHGKGSYD 420 Query: 428 VFSHRKSIVKRSTRIDFGIVYPPYGNKVKLARKLLK 463 FSH KSI+K+S ++D + YPP+ N + L +KL+K Sbjct: 421 TFSHTKSIMKKSNKLDIPLRYPPFRNHLSLLKKLMK 456 >ref|NP_646678.1| aldehyde dehydrogenase [Staphylococcus aureus subsp. aureus MW2] dbj|BAB95726.1| aldehyde dehydrogenase [Staphylococcus aureus subsp. aureus MW2] Length = 459 Score = 487 bits (1253), Expect = e-136, Method: Compositional matrix adjust. Identities = 233/455 (51%), Positives = 312/455 (68%) Query: 9 VEQMLEETREFFHTGATRAVAFRLEQLQKLKNAIKRCETQLITALKKDLRKSEFEAYATE 68 +EQ +++ FF+T T+ ++FR EQL+KL AIK E+ ++ AL DL K++ EAYATE Sbjct: 4 IEQKFYDSKAFFNTQQTKDISFRKEQLKKLSKAIKSYESDILEALYTDLGKNKVEAYATE 63 Query: 69 IGFTLDSIGYMMKHLKRWAKPVKVKSPLHMFPAKSLILSEPYGTVLVIGPFNYPFQLLIE 128 IG TL SI K LK W K V +PL++FP KS I EPYGTVL+I PFNYPFQL+ E Sbjct: 64 IGITLKSIKIARKELKNWTKTKNVDTPLYLFPTKSYIKKEPYGTVLIIAPFNYPFQLVFE 123 Query: 129 PLIGAIAAGNCAVLKPSESTPAVSGVIEDMIRETFEPAYIRVVQGEKEMTTLLIHTKFDY 188 PLIGAIAAGN A++KPSE TP V+ VI+ +I ETF+ YI V++G E T LIH FDY Sbjct: 124 PLIGAIAAGNTAIIKPSELTPNVARVIKRLINETFDANYIEVIEGGIEETQTLIHLPFDY 183 Query: 189 IFFTGSVPVGKIVMEAAAKNLVPVTLELGGKSPVIVDKTADLESAAKRIVWGKLINAGQT 248 +FFTGS VGKIV +AA++NLVPVTLE+GGKSPVIVD+TA+++ A++RI +GK NAGQT Sbjct: 184 VFFTGSENVGKIVYQAASENLVPVTLEMGGKSPVIVDETANIKVASERICFGKFTNAGQT 243 Query: 249 CIAPDYLLVHSEIAAELIRRIKHYVTVFYGSDSQRSPDYGRIVNERQLQRIRGMLEKDQA 308 C+APDY+LVH + +LI + + FYG + Q+SPDYGRIVN + R+ +L Q Sbjct: 244 CVAPDYILVHESVKDDLITALSKTLREFYGQNIQQSPDYGRIVNLKHYHRLTSLLNSAQM 303 Query: 309 KIILGGRVLAEDLYIEPTLIHPAAWSDASMADEIFGPVLPIMEYSRLEEAIQSVNEHPKP 368 I+ GG ++ YIEPTL+ A M +EIFGP+LPI+ Y L+EAI +++ PKP Sbjct: 304 NIVFGGHSDEDERYIEPTLLDHVTSDSAIMQEEIFGPILPILTYQSLDEAIAFIHQRPKP 363 Query: 369 LALYLFTEDKQVEQEVLGRVSFGGGCVNDTITHVASTHLPFXXXXXXXXXXXXXRHSFDV 428 L+LYLF+ED+ Q V+ +SFGGG +NDT+ H+A+ LPF ++SFD Sbjct: 364 LSLYLFSEDENATQRVINELSFGGGAINDTLMHLANPKLPFGGVGASGMGRYHGKYSFDT 423 Query: 429 FSHRKSIVKRSTRIDFGIVYPPYGNKVKLARKLLK 463 F+H KS + +STR++ G+ PPY K K + K Sbjct: 424 FTHEKSYIFKSTRLESGVHLPPYKGKFKYIKAFFK 458 >emb|CAA71129.1| aldehyde dehydrogenase [Staphylococcus aureus] Length = 459 Score = 486 bits (1250), Expect = e-136, Method: Compositional matrix adjust. Identities = 233/455 (51%), Positives = 311/455 (68%) Query: 9 VEQMLEETREFFHTGATRAVAFRLEQLQKLKNAIKRCETQLITALKKDLRKSEFEAYATE 68 +EQ +++ FF+T T+ ++FR EQL+KL AIK E+ ++ AL DL K++ EAYATE Sbjct: 4 IEQKFYDSKAFFNTQQTKDISFRKEQLKKLSKAIKSYESDILEALYTDLGKNKVEAYATE 63 Query: 69 IGFTLDSIGYMMKHLKRWAKPVKVKSPLHMFPAKSLILSEPYGTVLVIGPFNYPFQLLIE 128 IG TL SI K LK W K V +PL++FP KS EPYGTVLVI PFNYPFQL+ E Sbjct: 64 IGITLKSIKIARKELKNWTKTKNVDTPLYLFPTKSYFKKEPYGTVLVIAPFNYPFQLVFE 123 Query: 129 PLIGAIAAGNCAVLKPSESTPAVSGVIEDMIRETFEPAYIRVVQGEKEMTTLLIHTKFDY 188 PLIGAIAAGN A++KPSE TP V+ VI+ +I ETF+ YI V++G E T LIH FDY Sbjct: 124 PLIGAIAAGNTAIIKPSELTPNVARVIKRLINETFDANYIEVIEGGIEETQTLIHLPFDY 183 Query: 189 IFFTGSVPVGKIVMEAAAKNLVPVTLELGGKSPVIVDKTADLESAAKRIVWGKLINAGQT 248 +FFTGS VGKIV +AA++NLVPVTLE+GGKSPVIVD+TA+++ A++RI +GK NAGQT Sbjct: 184 VFFTGSENVGKIVYQAASENLVPVTLEMGGKSPVIVDETANIKVASERICFGKFTNAGQT 243 Query: 249 CIAPDYLLVHSEIAAELIRRIKHYVTVFYGSDSQRSPDYGRIVNERQLQRIRGMLEKDQA 308 C+APDY+LVH + +LI + + FYG + Q+SPDYGRIVN + R+ +L Q Sbjct: 244 CVAPDYILVHESVKDDLITALSKTLREFYGQNIQQSPDYGRIVNLKHYHRLTSLLNSAQM 303 Query: 309 KIILGGRVLAEDLYIEPTLIHPAAWSDASMADEIFGPVLPIMEYSRLEEAIQSVNEHPKP 368 I+ GG ++ YIEPTL+ A M +EIFGP+LPI+ Y L+EAI +++ PKP Sbjct: 304 NIVFGGHSDEDERYIEPTLLDHVTSDSAIMQEEIFGPILPILTYQSLDEAIAFIHQRPKP 363 Query: 369 LALYLFTEDKQVEQEVLGRVSFGGGCVNDTITHVASTHLPFXXXXXXXXXXXXXRHSFDV 428 L+LYLF+ED+ Q V+ +SFGGG +NDT+ H+A+ LPF ++SFD Sbjct: 364 LSLYLFSEDENATQRVINELSFGGGAINDTLMHLANPKLPFGGVGASGMGRYHGKYSFDT 423 Query: 429 FSHRKSIVKRSTRIDFGIVYPPYGNKVKLARKLLK 463 F+H KS + +STR++ G+ PPY K K + K Sbjct: 424 FTHEKSYICKSTRLESGVHLPPYKGKFKYIKAFFK 458 >ref|NP_372444.1| aldehyde dehydrogenase [Staphylococcus aureus subsp. aureus Mu50] ref|NP_375027.1| aldehyde dehydrogenase [Staphylococcus aureus subsp. aureus N315] pir||G89980 aldehyde dehydrogenase [imported] - Staphylococcus aureus (strain N315) dbj|BAB43006.1| aldehyde dehydrogenase [Staphylococcus aureus subsp. aureus N315] dbj|BAB58082.1| aldehyde dehydrogenase [Staphylococcus aureus subsp. aureus Mu50] Length = 459 Score = 485 bits (1249), Expect = e-136, Method: Compositional matrix adjust. Identities = 232/455 (50%), Positives = 312/455 (68%) Query: 9 VEQMLEETREFFHTGATRAVAFRLEQLQKLKNAIKRCETQLITALKKDLRKSEFEAYATE 68 +EQ +++ FF+T T+ ++FR +QL+KL AIK E+ ++ AL DL K++ EAYATE Sbjct: 4 IEQKFYDSKAFFNTQQTKDISFRKDQLKKLSKAIKSYESDILEALYTDLGKNKVEAYATE 63 Query: 69 IGFTLDSIGYMMKHLKRWAKPVKVKSPLHMFPAKSLILSEPYGTVLVIGPFNYPFQLLIE 128 IG TL SI K LK W K V +PL++FP KS I EPYGTVL+I PFNYPFQL+ E Sbjct: 64 IGITLKSIKNARKELKNWTKTKNVDTPLYLFPTKSYIKKEPYGTVLIIAPFNYPFQLVFE 123 Query: 129 PLIGAIAAGNCAVLKPSESTPAVSGVIEDMIRETFEPAYIRVVQGEKEMTTLLIHTKFDY 188 PLIGAIAAGN A++KPSE TP V+ VI+ +I ETF+ YI V++G E T LIH FDY Sbjct: 124 PLIGAIAAGNTAIIKPSELTPNVARVIKRLINETFDANYIEVIEGGIEETQTLIHLPFDY 183 Query: 189 IFFTGSVPVGKIVMEAAAKNLVPVTLELGGKSPVIVDKTADLESAAKRIVWGKLINAGQT 248 +FFTGS VGKIV +AA++NLVPVTLE+GGKSPVIVD+TA+++ A++RI +GK NAGQT Sbjct: 184 VFFTGSENVGKIVYQAASENLVPVTLEMGGKSPVIVDETANIKVASERICFGKFTNAGQT 243 Query: 249 CIAPDYLLVHSEIAAELIRRIKHYVTVFYGSDSQRSPDYGRIVNERQLQRIRGMLEKDQA 308 C+APDY+LVH + +LI + + FYG + Q+SPDYGRIVN + R+ +L Q Sbjct: 244 CVAPDYILVHESVKDDLITALSKTLREFYGQNIQQSPDYGRIVNLKHYHRLTSLLNSAQM 303 Query: 309 KIILGGRVLAEDLYIEPTLIHPAAWSDASMADEIFGPVLPIMEYSRLEEAIQSVNEHPKP 368 I+ GG ++ YIEPTL+ A M +EIFGP+LPI+ Y L+EAI +++ PKP Sbjct: 304 NIVFGGHSDEDERYIEPTLLDHVTSDSAIMQEEIFGPILPILTYQSLDEAIAFIHQRPKP 363 Query: 369 LALYLFTEDKQVEQEVLGRVSFGGGCVNDTITHVASTHLPFXXXXXXXXXXXXXRHSFDV 428 L+LYLF+ED+ Q V+ +SFGGG +NDT+ H+A+ LPF ++SFD Sbjct: 364 LSLYLFSEDENATQRVINELSFGGGAINDTLMHLANPKLPFGGVGASGMGRYHGKYSFDT 423 Query: 429 FSHRKSIVKRSTRIDFGIVYPPYGNKVKLARKLLK 463 F+H KS + +STR++ G+ PPY K K + K Sbjct: 424 FTHEKSYIFKSTRLESGVHLPPYKGKFKYIKAFFK 458 >ref|NP_765158.1| aldehyde dehydrogenase [Staphylococcus epidermidis ATCC 12228] gb|AAO05202.1| aldehyde dehydrogenase [Staphylococcus epidermidis ATCC 12228] Length = 459 Score = 472 bits (1214), Expect = e-132, Method: Compositional matrix adjust. Identities = 223/455 (49%), Positives = 309/455 (67%) Query: 9 VEQMLEETREFFHTGATRAVAFRLEQLQKLKNAIKRCETQLITALKKDLRKSEFEAYATE 68 + ++ FF+T T+ + FR +QL+ L IK E +L+ AL KDL KS+ EAYATE Sbjct: 4 IRDKFNNSKAFFNTHKTKNLKFRKQQLKLLSKNIKNHENELLDALYKDLGKSKVEAYATE 63 Query: 69 IGFTLDSIGYMMKHLKRWAKPVKVKSPLHMFPAKSLILSEPYGTVLVIGPFNYPFQLLIE 128 IG L SI M K LK W+K + +PL++FP KS I EPYGTVL+IGPFNYP QL+ E Sbjct: 64 IGMLLKSIKLMRKELKNWSKTKQTDTPLYLFPTKSYIKKEPYGTVLIIGPFNYPVQLVFE 123 Query: 129 PLIGAIAAGNCAVLKPSESTPAVSGVIEDMIRETFEPAYIRVVQGEKEMTTLLIHTKFDY 188 PLIGAIAAGN A++KPSE TP V+ VI+D+I +TF+ AY+ VV+G E T L+ FDY Sbjct: 124 PLIGAIAAGNTAIVKPSELTPHVAIVIKDIIEDTFDEAYVSVVEGGIEETQTLLSLPFDY 183 Query: 189 IFFTGSVPVGKIVMEAAAKNLVPVTLELGGKSPVIVDKTADLESAAKRIVWGKLINAGQT 248 +FFTGS VGKIV EAAA+ L+PVTLELGGKSPVIVD TA+++ A++RI +GK NAGQT Sbjct: 184 MFFTGSEKVGKIVYEAAARKLIPVTLELGGKSPVIVDDTANIKVASERISFGKFTNAGQT 243 Query: 249 CIAPDYLLVHSEIAAELIRRIKHYVTVFYGSDSQRSPDYGRIVNERQLQRIRGMLEKDQA 308 C+APDY+LV ++ +LI+ +K +T FYG + ++SPD+GRIVN++ R+ +++ + Sbjct: 244 CVAPDYILVQRKVKNDLIKALKKTITEFYGENIEKSPDFGRIVNQKHFNRLNDLIQIHKD 303 Query: 309 KIILGGRVLAEDLYIEPTLIHPAAWSDASMADEIFGPVLPIMEYSRLEEAIQSVNEHPKP 368 ++ GG EDLYIEPTL+ + M +EIFGP+LPI+ Y +E ++ + KP Sbjct: 304 NVVFGGNSSKEDLYIEPTLLDNITNDNKIMKEEIFGPILPIITYDNFDEVLEIIQSKSKP 363 Query: 369 LALYLFTEDKQVEQEVLGRVSFGGGCVNDTITHVASTHLPFXXXXXXXXXXXXXRHSFDV 428 L+LYLF+ED+ + V+ +SFGGG +NDT+ H+A+ +LPF ++SFD Sbjct: 364 LSLYLFSEDENMAHRVVEELSFGGGAINDTLMHLANPNLPFGGVGSSGIGQYHGKYSFDT 423 Query: 429 FSHRKSIVKRSTRIDFGIVYPPYGNKVKLARKLLK 463 FSH KS +STR++ + +PPY K K + K Sbjct: 424 FSHMKSYTFKSTRLESSLFFPPYKGKFKYIKTFFK 458 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.321 0.137 0.395 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 646,763,829 Number of extensions: 25934196 Number of successful extensions: 72459 Number of sequences better than 1.0e-05: 3994 Number of HSP's gapped: 65497 Number of HSP's successfully gapped: 4001 Length of query: 463 Length of database: 757,237,578 Length adjustment: 129 Effective length of query: 334 Effective length of database: 406,989,807 Effective search space: 135934595538 Effective search space used: 135934595538 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 128 (53.9 bits)