BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0382.0029.p (1606 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_389603.1| polyketide synthase of type I [Bacillus subtili... 537 e-150 emb|CAB13604.2| polyketide synthase of type I [Bacillus subtilis... 535 e-150 emb|CAB13603.2| polyketide synthase [Bacillus subtilis subsp. su... 483 e-134 pir||T44806 mycosubtilin synthetase chain mycA [imported] - Baci... 478 e-133 dbj|BAB69698.1| iturin A synthetase A [Bacillus subtilis] 469 e-130 >ref|NP_389603.1| polyketide synthase of type I [Bacillus subtilis] pir||E69679 polyketide synthetase pksP [similarity] - Bacillus subtilis Length = 4930 Score = 537 bits (1383), Expect = e-150, Method: Compositional matrix adjust. Identities = 437/1643 (26%), Positives = 756/1643 (46%), Gaps = 206/1643 (12%) Query: 10 EQVKQHKLTQEEAKQ-MLRELKSEGAKKEDIAIIGISCRLPKASNTDEYWSNLMGGLDCK 68 EQ + K + +Q ML A E IAI+GIS P A + + YW+ L G DC Sbjct: 1992 EQAVRAKAKRRRKQQVMLPNAIQSDAGPEPIAIVGISGIFPMAKDVEAYWNILKEGKDCM 2051 Query: 69 VEFQKEMIEHIKPIVNNKAYADFMGARFISEEEAEDCKMGGYLEDVDKFDAELFNISPKE 128 E K+ + + ++ G E + K GG+++ + FD F ISP+E Sbjct: 2052 TEIPKDRWD----------WREYEGDP-AKEVNKTNVKWGGFIDGIADFDPLFFGISPRE 2100 Query: 129 AKAMDPSHRVLLETVWTAIEDAGYAGDKIYGSQTSLYVGKDHV--NDTLYRYVTEDESTS 186 A+ M+P R+LL W AIEDAGY+ ++ G++T +++G + + L + + E ++ Sbjct: 2101 AEQMEPQQRLLLTYAWKAIEDAGYSAKRLSGTKTGVFIGTGNTGYSSLLSKANSAIEGSA 2160 Query: 187 MTGNWPGLMAGRINYLLNLKGNSMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLG 246 P + R++Y LNL G S +D+ACSS L+ +H A ++++ C+MA+ ++ Sbjct: 2161 AANTSPSVGPNRVSYFLNLHGPSEPVDTACSSSLVAIHHAISSIEEGTCDMALAGGVNTI 2220 Query: 247 IFPR-FSTARKSMMESQDDRVKTFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIK 305 I P + + K+ S++ + KTF ADG +G + LK L A + GD+IY VIK Sbjct: 2221 ILPEVYISFDKAGALSKEGKCKTFSNQADGFAHGEGAGILFLKKLKAAEEAGDHIYGVIK 2280 Query: 306 GSAVNNDGASNGLTAPNAVAQEEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGL 365 GSA+N+ G + LT PN AQ +V+ A++ A IDP T+ YIEAHGTGT+LGDP+EI GL Sbjct: 2281 GSAINHGGRAASLTTPNPKAQADVIQSAYQKAGIDPKTVTYIEAHGTGTELGDPVEINGL 2340 Query: 366 TNAFAK------HTDKAQFCGIGSVKANIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFK 419 +AF T +CG+GSVK NIGH +G A +IK++L +KH + S+H + Sbjct: 2341 KSAFKALGVNEGDTSANPYCGLGSVKTNIGHLSLAAGAAGVIKILLQLKHKTLVKSLHCE 2400 Query: 420 EPNSLINFIKSPVFVTEKPLQWPK------SVLPRRAGINSFGFVGTNAHVVVEEAPDQA 473 N I SP ++ + +W LPRRAG++SFG G NAHV++EE +A Sbjct: 2401 NVNPYIQLKNSPFYIVRETEEWKALKNEQGEELPRRAGVSSFGIGGVNAHVIIEEYIPEA 2460 Query: 474 ATSE--AAGPEYE-IFTVSAKTEHSLRQLIHQYAEFFRQGT--ETNLSNICYTAKTGRGH 528 + + PE+ IF +SAK E L++ Q A+ + T + NL+ I YT + GR Sbjct: 2461 SDENIPSIAPEHPGIFVLSAKNEARLKEHAQQLADALDKQTYSDVNLARIAYTLQAGRDA 2520 Query: 529 YAYRLALIVKSYEELEQKISKLAS--NGLSDISGKGVYYDCHKIGSDRKQVRDQGEI-TL 585 RL +I S E+L++K+ A+ +G+ D+ K D+G + L Sbjct: 2521 MEERLGIISGSIEDLQKKLKDFAAEKSGVEDVF---------------KGRIDKGTLQML 2565 Query: 586 SEHRKLNSKAGSLLEEIVNDTSGYLILNLAEICNLYVKGAKVEWSLMYRDNKRRIVSLPT 645 +E ++ +E A++ L+VKG V+W+ +Y +N + +SLPT Sbjct: 2566 TEDEEIQEAVEKWMER----------GKYAKLLELWVKGLDVDWTKLYGENLPKRISLPT 2615 Query: 646 YQFDRVMYW--------GEVKDRRSELEVSVKNISHPLIDQCLADSMDETIYSTTFNVNT 697 Y F + YW G + ++ + V + HPL+ Q ++ + E +S+ + Sbjct: 2616 YPFAKDRYWISDHIEKSGSIDANQAASRLGV--VLHPLMHQNTSN-LSEQRFSSIY-TGE 2671 Query: 698 HWVLSDHKIMGVSVIPGTTYLEMGRKACSRLYHTD----YLELRDVFFFTPLSVGQTEDK 753 + L+DH + G ++PG +LE+ R A + ++L++ + P+ V + + + Sbjct: 2672 EFFLADHVVKGQRILPGVAHLELARAAVEQAAEVQGVPRIMKLKNAVWVRPIVV-EDQPQ 2730 Query: 754 QVHT-IVKKEKGYTRFII-----ASQEQGKWITHAEGKA-YNPADESKDAERLIFDLAAA 806 QVH ++ E G + I + EQ I +++G A NPA+ DL + Sbjct: 2731 QVHIRLLPGENGEISYEIYGHSDVTGEQS--IVYSQGSAVLNPAENLP-----AVDLQSL 2783 Query: 807 RNDSRKETIKVKYEDTSLSSKVFSFGPRWLNFKEVILDHNEQLVELELSEAFKGDLEELI 866 R ++ V + F +GP + K++ L +L L + L + Sbjct: 2784 REQCQESHFSVNEVYDTYRMIGFEYGPAYRGVKKIYTAEQFVLAKLSLHPSAADTLSQYK 2843 Query: 867 LHPSLLDN---AANVFIGEDDDDSTFLPLSYKNIKIYSAMPQHFYAYVQKKSGNKETKTC 923 +HP L+D+ A+++ G D+ T LP + + ++++ A + Y + G+K T Sbjct: 2844 MHPGLMDSALQASSILTGAGDNQLT-LPFAVQELEVFGACSSEMWVYARYSQGSKATDKV 2902 Query: 924 ---DIQLIDMQGRIFVEIKDYVLKKVNHLLTLFKENDDLSGAFYRLNWVQAEPAAEGRRG 980 D+ ++D G + V +K + + + L+ + WV + E Sbjct: 2903 QKRDMDILDESGNVCVRMKGLSFRAAEGGSGSAESDQTLATLMFEEKWVPKDFKKESPEP 2962 Query: 981 H-EGTVLVFKDTQGIYENIAGPLQNKAADTIQVEFGEAYKRLTPNHYVIQGTENDYINLM 1039 H E +++ D G+ + D I+ R+T ++ Sbjct: 2963 HYERHIVMLCDMNGL-----------SKDRIE-------SRMTGAECIV----------- 2993 Query: 1040 NEIKDRNIRQILHLSSITGEAAATCADLADQQNRSLHSLFYLAKSISSNKIKENIDVVLI 1099 L S A D A+Q ++ L ++ + N+ + L+ Sbjct: 2994 -------------LESFREGLAERFQDYAEQALETVQGLL-------KSRPQGNVLIQLL 3033 Query: 1100 SDNVTEVTGHEQEINPLGAALFGLGTVLTQEFKNIHCRALDVDRETPAELISEEI---QR 1156 T + + L A L G E K + + +++D E + E++ +R Sbjct: 3034 ----TSAQRKQYSFSGLSALLKTAGL----ENKKLIGQTIEIDSHENVESVIEKLKENKR 3085 Query: 1157 IESKYQVALRSGKRYTCELDRHEPEHQEEQGLEIKEQGVYXXXXXXXXXXLEIARYLAGK 1216 + GKRY +LD + + + E + +++GVY A+ +A + Sbjct: 3086 HTEDQHIKYEKGKRYINDLDEMQIDDR-EISMPWRDKGVYLITGGAGGLGFIFAKEIARQ 3144 Query: 1217 NAVHIALMN-RSKLPEAASWDQLIQENPEHKLSRKLQAIKDIRESGSEVSCYSCDIADPD 1275 + ++ RS L + DQ + N ++++ G+ D+ + Sbjct: 3145 AEQPVLILTGRSAL----NADQQAELN-------------ELQQLGARAEYRQVDVTQTE 3187 Query: 1276 QVNEVVQDLKGKYGRIHGIFHCAGVAGEGFTFRKPKAVFNEVVSPKVTGTWILDQATREE 1335 +E++ + Y ++G+ H AG+ + + K +V++PKV G +D+AT Sbjct: 3188 AASELITSITSDYEDLNGVIHSAGLIKDNYLMSKTNEELTQVLAPKVKGLVNVDEATEHL 3247 Query: 1336 NLEFFILFSSINAIFGGSGQGDYTAANAYLDSFSYSRNK------RGARTISINWPAWSE 1389 L+FFILFSSI+++ G +GQ DY ANA++DS++ RN R +T+SINWP W E Sbjct: 3248 ALDFFILFSSISSVAGSAGQADYAMANAFMDSYAAYRNALVTAMYRHGQTLSINWPLWKE 3307 Query: 1390 VGIAADYGITEESSVFHMLTVKQALNFMDEMAAGGITHAIPGSLNRPLLASVQDQLPFTL 1449 G+ A+ I +T+K GI G LA +DQ+ + Sbjct: 3308 GGMRANKEIEN-------MTLKNT-GVTPMRTETGIQALYKG------LAFGKDQV-IVM 3352 Query: 1450 SG---AIRSKLKGTGRTRTEPKETPEIEAAGDIVLKGKGTEYSETEKNIAQMYSLILDM- 1505 G +R KL + P +T ++ + + +G + ++ + Q S +L + Sbjct: 3353 EGFKDMMREKLTQKPSSDDVPMKTVQVRVTSEARMD-QGNMFDHIQEVLKQTISQLLKIK 3411 Query: 1506 -HELDLYESFNAMGGDSIMATQLLKLIDKKYPDIVDISDIFTYSSVVELAEYIDRESHRS 1564 E+D FN G DSI T+ +++K + + F +++V A Y+ E + Sbjct: 3412 PEEIDPDMEFNQYGFDSITLTEFANTLNEKCKLDLTPTVFFEHATVYAFAGYLSEEYPNA 3471 Query: 1565 -TPPAPVKAETVSEPVEQELRDL 1586 T P KAE + +PVEQ ++++ Sbjct: 3472 FTAQTPAKAEVLMQPVEQNIKNM 3494 Score = 454 bits (1169), Expect = e-126, Method: Compositional matrix adjust. Identities = 399/1426 (27%), Positives = 649/1426 (45%), Gaps = 212/1426 (14%) Query: 37 EDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKPIVNNKAYADFMGARF 96 + +AI+GISC+ P A N ++W+++ KE E I+ A+ + Sbjct: 533 DSVAIVGISCQFPGAKNHHDFWNHI-----------KEGKESIRFFSEEDVRANGVPEEL 581 Query: 97 ISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAGDK 156 I + + + +E D FD F ISPK+A+ MDP R+LL W AIEDAGY + Sbjct: 582 I--QHPDYVPVQSVIEGKDLFDPGFFQISPKDAEYMDPQLRLLLLHSWKAIEDAGYVAKE 639 Query: 157 IYGSQTSLYVGKDHVNDTLYRYVTED-ESTSMTGNW----PGLMAGRINYLLNLKGNSMV 211 I + + + L + TE ES +W G + I++ L LKG S Sbjct: 640 IPATSVYMSASSNSYRTLLPKETTEGHESPDGYVSWVLAQSGTIPTMISHKLGLKGPSYF 699 Query: 212 LDSACSSGLLGVHLACNALKNKECEMAIVSAISLGIFPRFSTARKSMME-SQDDRVKTFD 270 + S CSS L+G++ A +L + E + A+V +L ++ + S D VK FD Sbjct: 700 VHSNCSSSLVGLYQAYKSLTSGESQYALVGGATLHAQSAIGYVHQNGLNFSSDGHVKAFD 759 Query: 271 KNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASN-GLTAPNAVAQEEV 329 +ADG +GVA ++LK A +DGD+IYA+++G +NNDGA G AP+ Q EV Sbjct: 760 ASADGMAGGEGVAVILLKKAVDAVKDGDHIYAIMRGIGINNDGAEKAGFYAPSVKGQTEV 819 Query: 330 LLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQFCGIGSVKANIG 389 + + +I P T+ YIEAHGTGTKLGDPIE+ L + ++TDK QFCGIGSVK NIG Sbjct: 820 IQHVLDTTKIHPETVSYIEAHGTGTKLGDPIEMSALNKVYKQYTDKTQFCGIGSVKTNIG 879 Query: 390 HTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPKSVLPRR 449 H +GLA IKV +S+ HN + +I+ EPN I F SP +V + K R Sbjct: 880 HLDTAAGLAGCIKVAMSLYHNELAPTINCTEPNPDIKFESSPFYVVRERKSLEKHAGVHR 939 Query: 450 AGINSFGFVGTNAHVVVEEAPDQA-ATSEAAGPEYEIFTVSAKTEHSLRQLIHQYAEFFR 508 A ++SFG GTNAH + E+ + + A +E G + I +SAK L+ + + Sbjct: 940 AALSSFGLGGTNAHAIFEQYENISDAGAENEGNQPYIIPISAKNSERLQVYAKEMLSYIS 999 Query: 509 QGTETNLS--NICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASNGLSDISGKGVYYD 566 Q + + S +I YT + GR R+ IV EE + ++ ++GK + Sbjct: 1000 QDEQRHFSLRDIAYTFQVGREAMDNRIVFIVNDLEEWKHQLEAF-------VTGKPLAEG 1052 Query: 567 CHKIGSDRKQVRDQGE---ITLSEHRKLNSKAGSLLEEIVNDTSGYLILNLAEICNLYVK 623 C QGE +T +E N++A + ++ L ++ ++ Sbjct: 1053 C-----------IQGEKTRMTSAEQLLGNAEADDMASSRISKE------ELRKLAEMWAN 1095 Query: 624 GAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWGEVKDRRSELEVSVKNISHPLIDQCLADS 683 G VEW +Y + K R +SLPTY F YW E + + HPL + Sbjct: 1096 GFHVEWRRLYPNIKPRRISLPTYPFAEERYWPE--SSTGAITTIEPSRLHPL-EHHNTSV 1152 Query: 684 MDETIYSTTFNVNTHWVLSDHKIMGVSVIPGTTYLEMGRKACSRLY-----HTDYLELRD 738 + E +S+ F + +++H I G++++P LEM R A + H + L++ Sbjct: 1153 LSEQRFSSIF-TGQEYFIAEHIIKGMAILPAAVTLEMARAAIEQGIGGLEDHETGIRLKN 1211 Query: 739 VFFFTPLSVGQTEDKQVHTIVKKEKGYTRFIIASQEQGKWITHAEGKAYNPADESKDAER 798 V + P+ G +E QV+ + E G H + Y ES DAE Sbjct: 1212 VVWVRPVVAG-SEPVQVNIGLYDEDG---------------GHIAYRMYGDP-ESADAEP 1254 Query: 799 LIFDLAAARNDSRKETIKVKYEDTSLSSKV--------------------FSFGPRWLNF 838 +++ N + E I++K E SK+ +GP + + Sbjct: 1255 VVY------NQGKAELIQLKREKALDLSKIKKQCDQSKMDAASFYEGMIGADYGPGYKSV 1308 Query: 839 KEVILDHNEQLVELELSEAFKGDLEELILHPSLLDNA-------ANVFIGEDDDDSTF-- 889 + V + L +L L E+ L + +LHPS++D A NV E D F Sbjct: 1309 EAVYKGDGQLLAKLSLPESVAHTLGDYVLHPSVMDGALQAAEYLQNVVRAELSDTEDFKA 1368 Query: 890 -LPLSYKNIKIYSAMPQHFYAYVQKKSGNKE---TKTCDIQLIDMQGRIFVEIKDYVLKK 945 LP + + ++++ + YVQ S NK + DI L D G I V +K + Sbjct: 1369 ALPFALEELEVFRQCVSDMWVYVQFNSKNKPGDLIQKVDIHLCDEHGMICVRLKGFS--- 1425 Query: 946 VNHLLTLFKENDDLSGAFYRLNWVQAEPAAEGRRGHEGTVLVFKDTQGIYENIAGPLQNK 1005 T E D +Q EP+ + + T+L+ Q +++ + K Sbjct: 1426 -----TRVMEAD-----------IQTEPS----KINAETLLL----QPVWQ------EQK 1455 Query: 1006 AADTIQVEFGEAYKRLTPNHYVIQGTENDYINLMNEIKDRNIRQI------LHLSSITGE 1059 AA+++ A K+ +++ + E +QI +H+ S+ E Sbjct: 1456 AANSL------AAKKYA-----------EHLVFLCEYDHETRKQIEAAIEDVHVYSL--E 1496 Query: 1060 AAATCADLADQQNRSLHSLFYLAKSISSNKIKENIDVVLISDNVTEVTGHEQEINPLGAA 1119 A + D + + +F + I K K+ I V + VT G +Q L + Sbjct: 1497 ARPSSVD--GRFHSYTEQVFKKVQEIIRTKPKDGILVQI----VTSAEGEQQ----LFSG 1546 Query: 1120 LFGLGTVLTQEFKNIHCRALDVDRETPAELISEEI--QRIESKYQVALRSGKRYTCELDR 1177 L GL QE + + ++V E E I+ ++ ++ S V ++G RY + R Sbjct: 1547 LTGLLKTACQENAKLTGQMIEVSSEESGESIAGKLLENQMSSDSYVKYQNGTRYIADW-R 1605 Query: 1178 HEPEHQEEQGLEIKEQGVYXXXXXXXXXXLEIARYLA--GKNAVHIALMNRSKLPEAASW 1235 + + + K+ GVY A+ +A KNA + L RS L E+ S Sbjct: 1606 EIKQAKGDGSKPWKDNGVYLISGGAGGLGHIFAKEIAEQTKNAT-VILAGRSPLSESKS- 1663 Query: 1236 DQLIQENPEHKLSRKLQAIKDIRESGSEVSCYSCDIADPDQVNEVVQDLKGKYGRIHGIF 1295 + +K++ G++++ D+ + +V +++ D++ +YGR++GI Sbjct: 1664 ----------------KKLKELHSKGADITYRQTDVTNKIEVYQLIDDIQKRYGRLNGIL 1707 Query: 1296 HCAGVAGEGFTFRKPKAVFNEVVSPKVTGTWILDQATREENLEFFILFSSINAIFGGSGQ 1355 H AG+ + + K ++V++PKV G LD+A+++ L+FFILFSS++ G GQ Sbjct: 1708 HSAGIIKDSYLVNKQAKDLHDVLAPKVKGLVYLDEASKDLPLDFFILFSSLSGSLGSIGQ 1767 Query: 1356 GDYTAANAYLDSFSYSRNK------RGARTISINWPAWSEVGIAAD 1395 DY AAN ++D ++ RN+ R +T+S+NWP W + G+ D Sbjct: 1768 SDYAAANVFMDMYAGYRNRLADLSQRHGQTLSVNWPLWRDGGMQVD 1813 Score = 449 bits (1154), Expect = e-124, Method: Compositional matrix adjust. Identities = 294/941 (31%), Positives = 472/941 (50%), Gaps = 76/941 (8%) Query: 35 KKEDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKPIVNNKAYADFMGA 94 K E IAI+G+S PKA + +EYW NL G DC E K+ + + ++ G Sbjct: 3517 KPEPIAIVGMSGVFPKAKDVEEYWKNLSSGADCITEVPKDRWD----------WQEYYGD 3566 Query: 95 RFISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAG 154 + E + K GG++++V FD F ISP EA+ M+P R+L+ W A+E+AG++ Sbjct: 3567 P-LKEANKTNVKWGGFIDEVADFDPLFFGISPLEAEQMEPQQRLLMTYAWKAVEEAGHSA 3625 Query: 155 DKIYGSQTSLYVGKDHVNDTLYRYVTEDESTSMTGNWPGLMAGRINYLLNLKGNSMVLDS 214 + G++T +++G + + + E ++ P R++Y LN+ G S +D+ Sbjct: 3626 RSLAGTKTGIFIGTGNTGYSSLLSNVDIEGSAAANMSPSAGPNRVSYFLNIHGPSEPIDT 3685 Query: 215 ACSSGLLGVHLACNALKNKECEMAIVSAISLGIFPRFSTAR-KSMMESQDDRVKTFDKNA 273 ACSS L+ +H A A++N CEMAI ++ + P+ A K+ S++ R KTF A Sbjct: 3686 ACSSSLVAIHHAVCAIENGNCEMAIAGGVNTVVTPQGHIAYDKAGALSKEGRCKTFSDKA 3745 Query: 274 DGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASNGLTAPNAVAQEEVLLKA 333 DG S+G + LK L+ A +DGD+IY VIKGSAVN+ G +N LT PN AQ +V+ A Sbjct: 3746 DGFAVSEGAGILFLKKLTAAERDGDHIYGVIKGSAVNHGGRANSLTTPNPKAQADVVKTA 3805 Query: 334 WEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDK-------AQFCGIGSVKA 386 +E A IDP T+ YIEAHGTGT+LGDP+EI GL AF + +K CG+GS K Sbjct: 3806 YEKAGIDPRTVTYIEAHGTGTELGDPVEINGLKAAFKELYEKTGDPAVHGSHCGLGSAKT 3865 Query: 387 NIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPK--- 443 NIGH +G+A +IKV+L +KH + S++ + N I SP ++ ++ +W Sbjct: 3866 NIGHLSLAAGVAGVIKVLLQLKHKTLVKSLYSETVNPYIRLDDSPFYIVQESREWQALRD 3925 Query: 444 ---SVLPRRAGINSFGFVGTNAHVVVEEAPDQAATSEAAGPEYE-----IFTVSAKTEHS 495 LPRRAGI+SFG G NAHVV+EE + T A P IF +SAK E Sbjct: 3926 EAGRELPRRAGISSFGIGGVNAHVVIEEYIPKETTHPATAPAVTAQHPGIFILSAKDEDR 3985 Query: 496 LRQLIHQYAEFF--RQGTETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASN 553 L+ Q A+F R T +L++I YT + GR RL +I S +L +K++ Sbjct: 3986 LKDQARQLADFISKRSITARDLTDIAYTLQEGRDAMEERLGIIAVSTGDLLEKLNLFIEG 4045 Query: 554 GLSDISGKGVYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLLEEIVNDTSGYLILN 613 G + K +Y R + E +++ + + + +++ +N++ I Sbjct: 4046 G---TNAKYMY-------------RGRAEKGIAQTLRSDDE----VQKTLNNSWEPHIYE 4085 Query: 614 LAEICNLYVKGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYW-GEVKDRRSELEVSVKNIS 672 + +L+VKG ++ WS +Y + + +SLPTY F + YW + K+ + + ++K + Sbjct: 4086 --RLLDLWVKGMEIGWSKLYDGKQPKRISLPTYPFAKERYWITDTKEEAAAHQTALKTVE 4143 Query: 673 ----HPLIDQCLADSMDETIYSTTFNVNTHWVLSDHKIMGVSVIPGTTYLEMGRKACSRL 728 HPLI +D + E +S+ F + +DHK+ G V+PG YLEM A +R Sbjct: 4144 SAALHPLIHVNTSD-LSEQRFSSAF-TGAEFFFADHKVKGKPVMPGVAYLEMVHAAVTRA 4201 Query: 729 Y-----HTDYLELRDVFFFTPLSVGQTEDKQVH-TIVKKEKGYTRFIIASQ-EQGKWITH 781 + +++V + P+ V + QV ++ ++ G F + ++ H Sbjct: 4202 VRRTEDQQSVIHIKNVVWVQPI-VADGQPVQVDISLNPQQDGEIAFNVYTEAAHNDRKIH 4260 Query: 782 AEGKAYNPADESKDAERLIFDLAAARNDSRKETIKVKYEDTSLSSKVFSFGPRWLNFKEV 841 +G A + + D++A ++ T+ + +GP + + Sbjct: 4261 CQGS----ASIRGAGDIPVQDISALQDQCSLSTLSHDQCYELFKAIGIDYGPGFQGIDRL 4316 Query: 842 ILDHNEQLVELELSEAFKGDLEELILHPSLLDNAANVFIG---EDDDDSTFLPLSYKNIK 898 + N+ L EL L L E +LHPS+ D+A IG D+ LP + + ++ Sbjct: 4317 YIGRNQALAELSLPAGVTHTLNEFVLHPSMADSALQASIGLKLNSGDEQLSLPFALQELE 4376 Query: 899 IYSAMPQHFYAYVQKKSGNKETKTCDIQLIDMQGRIFVEIK 939 I+S + V + + + DI L D QGR+ V IK Sbjct: 4377 IFSPCTNKMWVSVTSRPNEDKIQRLDIDLCDEQGRVCVRIK 4417 Score = 63.5 bits (153), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 72/339 (21%), Positives = 140/339 (41%), Gaps = 31/339 (9%) Query: 1066 DLADQQNRSLHSLFYLAKS-ISSNKIKENIDVVLISDNVTEVTGHEQEINPLGAALFGLG 1124 ++ + Q++ + ++ L K+ +S ++ I +++ N V H+ ++P+ A + GL Sbjct: 4534 EMIEAQDQGVIQMYRLIKAMLSLGYGQKEISWTIVTVNTQYVDQHDI-VDPVDAGVHGLI 4592 Query: 1125 TVLTQEFKNIHCRALDVDR-ETPAELISEEIQRIESKYQVALRSGKRYTCEL---DRHEP 1180 +++E+ N + +DV + E + + A R+ + L ++P Sbjct: 4593 GSMSKEYPNWQTKLIDVKKYEDLPLSQLLSLPADQEGNTWAYRNKIWHKLRLIPVHNNQP 4652 Query: 1181 EHQEEQGLEIKEQGVYXXXXXXXXXXLEIARYLAGKNAVHIALMNRSKLPEAASWDQLIQ 1240 H + K GVY + Y+ I + R K D IQ Sbjct: 4653 VHTK-----YKHGGVYVVIGGAGGIGEAWSEYMIRTYQAQIVWIGRRKK------DAAIQ 4701 Query: 1241 ENPEHKLSRKLQAIKDIRESGSEVSCYSCDIADPDQVNEVVQDLKGKYGRIHGIFHCAGV 1300 KL R G D A+ +++ + +K + I+GI H A V Sbjct: 4702 S----KLDR-------FARLGRAPYYIQADAANREELERAYETMKQTHREINGIIHSAIV 4750 Query: 1301 AGEGFTFRKPKAVFNEVVSPKVTGTWILDQATREENLEFFILFSSINAIFGGSGQGDYTA 1360 + + F V++ KV + + Q R E L+F + FSS+ + SGQ +Y A Sbjct: 4751 LQDRSLMNMSEECFRNVLAAKVDVSVRMAQVFRHEPLDFVLFFSSVQSFARASGQSNYAA 4810 Query: 1361 ANAYLDSFSYSRNKRGARTISI-NWPAWSEVGIAA--DY 1396 ++ D+F+ ++ T+++ NW W +G+ + DY Sbjct: 4811 GCSFKDAFAQRLSQVWPCTVAVMNWSYWGSIGVVSSPDY 4849 >emb|CAB13604.2| polyketide synthase of type I [Bacillus subtilis subsp. subtilis str. 168] Length = 5488 Score = 535 bits (1379), Expect = e-150, Method: Compositional matrix adjust. Identities = 436/1643 (26%), Positives = 755/1643 (45%), Gaps = 205/1643 (12%) Query: 10 EQVKQHKLTQEEAKQ-MLRELKSEGAKKEDIAIIGISCRLPKASNTDEYWSNLMGGLDCK 68 EQ + K + +Q ML A E IAI+GIS P A + + YW+ L G DC Sbjct: 2549 EQAVRAKAKRRRKQQVMLPNAIQSDAGPEPIAIVGISGIFPMAKDVEAYWNILKEGKDCM 2608 Query: 69 VEFQKEMIEHIKPIVNNKAYADFMGARFISEEEAEDCKMGGYLEDVDKFDAELFNISPKE 128 E K+ + + ++ G E + K GG+++ + FD F ISP+E Sbjct: 2609 TEIPKDRWD----------WREYEGDP-AKEVNKTNVKWGGFIDGIADFDPLFFGISPRE 2657 Query: 129 AKAMDPSHRVLLETVWTAIEDAGYAGDKIYGSQTSLYVGKDHV--NDTLYRYVTEDESTS 186 A+ M+P R+LL W AIEDAGY+ ++ G++T +++G + + L + + E ++ Sbjct: 2658 AEQMEPQQRLLLTYAWKAIEDAGYSAKRLSGTKTGVFIGTGNTGYSSLLSKANSAIEGSA 2717 Query: 187 MTGNWPGLMAGRINYLLNLKGNSMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLG 246 P + R++Y LNL G S +D+ACSS L+ +H A ++++ C+MA+ ++ Sbjct: 2718 AANTSPSVGPNRVSYFLNLHGPSEPVDTACSSSLVAIHHAISSIEEGTCDMALAGGVNTI 2777 Query: 247 IFPR-FSTARKSMMESQDDRVKTFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIK 305 I P + + K+ S++ + KTF ADG +G + LK L A + GD+IY VIK Sbjct: 2778 ILPEVYISFDKAGALSKEGKCKTFSNQADGFAHGEGAGILFLKKLKAAEEAGDHIYGVIK 2837 Query: 306 GSAVNNDGASNGLTAPNAVAQEEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGL 365 GSA+N+ G + LT PN AQ +V+ A++ A IDP T+ YIEAHGTGT+LGDP+EI GL Sbjct: 2838 GSAINHGGRAASLTTPNPKAQADVIQSAYQKAGIDPKTVTYIEAHGTGTELGDPVEINGL 2897 Query: 366 TNAFAK------HTDKAQFCGIGSVKANIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFK 419 +AF T +CG+GSVK NIGH +G A +IK++L +KH + S+H + Sbjct: 2898 KSAFKALGVNEGDTSANPYCGLGSVKTNIGHLSLAAGAAGVIKILLQLKHKTLVKSLHCE 2957 Query: 420 EPNSLINFIKSPVFVTEKPLQWPK------SVLPRRAGINSFGFVGTNAHVVVEEAPDQA 473 N I SP ++ + +W LPRRAG++SFG G NAHV++EE +A Sbjct: 2958 NVNPYIQLKNSPFYIVRETEEWKALKNEQGEELPRRAGVSSFGIGGVNAHVIIEEYIPEA 3017 Query: 474 ATSE--AAGPEYE-IFTVSAKTEHSLRQLIHQYAEFFRQGT--ETNLSNICYTAKTGRGH 528 + + PE+ IF +SAK E L++ Q A+ + T + NL+ I YT + GR Sbjct: 3018 SDENIPSIAPEHPGIFVLSAKNEARLKEHAQQLADALDKQTYSDVNLARIAYTLQAGRDA 3077 Query: 529 YAYRLALIVKSYEELEQKISKLAS--NGLSDISGKGVYYDCHKIGSDRKQVRDQGEI-TL 585 RL +I S E+L++K+ A+ +G+ D+ K D+G + L Sbjct: 3078 MEERLGIISGSIEDLQKKLKDFAAEKSGVEDVF---------------KGRIDKGTLQML 3122 Query: 586 SEHRKLNSKAGSLLEEIVNDTSGYLILNLAEICNLYVKGAKVEWSLMYRDNKRRIVSLPT 645 +E ++ +E A++ L+VKG V+W+ +Y +N + +SLPT Sbjct: 3123 TEDEEIQEAVEKWMER----------GKYAKLLELWVKGLDVDWTKLYGENLPKRISLPT 3172 Query: 646 YQFDRVMYW--------GEVKDRRSELEVSVKNISHPLIDQCLADSMDETIYSTTFNVNT 697 Y F + YW G + ++ + + HPL+ Q ++ + E +S+ + Sbjct: 3173 YPFAKDRYWISDHIEKSGSIDANQAASRLG-GAVLHPLMHQNTSN-LSEQRFSSIYT-GE 3229 Query: 698 HWVLSDHKIMGVSVIPGTTYLEMGRKACSRLYHTD----YLELRDVFFFTPLSVGQTEDK 753 + L+DH + G ++PG +LE+ R A + ++L++ + P+ V + + + Sbjct: 3230 EFFLADHVVKGQRILPGVAHLELARAAVEQAAEVQGVPRIMKLKNAVWVRPIVV-EDQPQ 3288 Query: 754 QVHT-IVKKEKGYTRFII-----ASQEQGKWITHAEGKA-YNPADESKDAERLIFDLAAA 806 QVH ++ E G + I + EQ I +++G A NPA+ DL + Sbjct: 3289 QVHIRLLPGENGEISYEIYGHSDVTGEQS--IVYSQGSAVLNPAENLP-----AVDLQSL 3341 Query: 807 RNDSRKETIKVKYEDTSLSSKVFSFGPRWLNFKEVILDHNEQLVELELSEAFKGDLEELI 866 R ++ V + F +GP + K++ L +L L + L + Sbjct: 3342 REQCQESHFSVNEVYDTYRMIGFEYGPAYRGVKKIYTAEQFVLAKLSLHPSAADTLSQYK 3401 Query: 867 LHPSLLDN---AANVFIGEDDDDSTFLPLSYKNIKIYSAMPQHFYAYVQKKSGNKETKTC 923 +HP L+D+ A+++ G D+ T LP + + ++++ A + Y + G+K T Sbjct: 3402 MHPGLMDSALQASSILTGAGDNQLT-LPFAVQELEVFGACSSEMWVYARYSQGSKATDKV 3460 Query: 924 ---DIQLIDMQGRIFVEIKDYVLKKVNHLLTLFKENDDLSGAFYRLNWVQAEPAAEGRRG 980 D+ ++D G + V +K + + + L+ + WV + E Sbjct: 3461 QKRDMDILDESGNVCVRMKGLSFRAAEGGSGSAESDQTLATLMFEEKWVPKDFKKESPEP 3520 Query: 981 H-EGTVLVFKDTQGIYENIAGPLQNKAADTIQVEFGEAYKRLTPNHYVIQGTENDYINLM 1039 H E +++ D G+ + D I+ R+T ++ Sbjct: 3521 HYERHIVMLCDMNGL-----------SKDRIE-------SRMTGAECIV----------- 3551 Query: 1040 NEIKDRNIRQILHLSSITGEAAATCADLADQQNRSLHSLFYLAKSISSNKIKENIDVVLI 1099 L S A D A+Q ++ L ++ + N+ + L+ Sbjct: 3552 -------------LESFREGLAERFQDYAEQALETVQGLL-------KSRPQGNVLIQLL 3591 Query: 1100 SDNVTEVTGHEQEINPLGAALFGLGTVLTQEFKNIHCRALDVDRETPAELISEEI---QR 1156 T + + L A L G E K + + +++D E + E++ +R Sbjct: 3592 ----TSAQRKQYSFSGLSALLKTAGL----ENKKLIGQTIEIDSHENVESVIEKLKENKR 3643 Query: 1157 IESKYQVALRSGKRYTCELDRHEPEHQEEQGLEIKEQGVYXXXXXXXXXXLEIARYLAGK 1216 + GKRY +LD + + + E + +++GVY A+ +A + Sbjct: 3644 HTEDQHIKYEKGKRYINDLDEMQIDDR-EISMPWRDKGVYLITGGAGGLGFIFAKEIARQ 3702 Query: 1217 NAVHIALMN-RSKLPEAASWDQLIQENPEHKLSRKLQAIKDIRESGSEVSCYSCDIADPD 1275 + ++ RS L + DQ + N ++++ G+ D+ + Sbjct: 3703 AEQPVLILTGRSAL----NADQQAELN-------------ELQQLGARAEYRQVDVTQTE 3745 Query: 1276 QVNEVVQDLKGKYGRIHGIFHCAGVAGEGFTFRKPKAVFNEVVSPKVTGTWILDQATREE 1335 +E++ + Y ++G+ H AG+ + + K +V++PKV G +D+AT Sbjct: 3746 AASELITSITSDYEDLNGVIHSAGLIKDNYLMSKTNEELTQVLAPKVKGLVNVDEATEHL 3805 Query: 1336 NLEFFILFSSINAIFGGSGQGDYTAANAYLDSFSYSRNK------RGARTISINWPAWSE 1389 L+FFILFSSI+++ G +GQ DY ANA++DS++ RN R +T+SINWP W E Sbjct: 3806 ALDFFILFSSISSVAGSAGQADYAMANAFMDSYAAYRNALVTAMYRHGQTLSINWPLWKE 3865 Query: 1390 VGIAADYGITEESSVFHMLTVKQALNFMDEMAAGGITHAIPGSLNRPLLASVQDQLPFTL 1449 G+ A+ I +T+K GI G LA +DQ+ + Sbjct: 3866 GGMRANKEIEN-------MTLKNT-GVTPMRTETGIQALYKG------LAFGKDQV-IVM 3910 Query: 1450 SG---AIRSKLKGTGRTRTEPKETPEIEAAGDIVLKGKGTEYSETEKNIAQMYSLILDM- 1505 G +R KL + P +T ++ + + +G + ++ + Q S +L + Sbjct: 3911 EGFKDMMREKLTQKPSSDDVPMKTVQVRVTSEARMD-QGNMFDHIQEVLKQTISQLLKIK 3969 Query: 1506 -HELDLYESFNAMGGDSIMATQLLKLIDKKYPDIVDISDIFTYSSVVELAEYIDRESHRS 1564 E+D FN G DSI T+ +++K + + F +++V A Y+ E + Sbjct: 3970 PEEIDPDMEFNQYGFDSITLTEFANTLNEKCKLDLTPTVFFEHATVYAFAGYLSEEYPNA 4029 Query: 1565 -TPPAPVKAETVSEPVEQELRDL 1586 T P KAE + +PVEQ ++++ Sbjct: 4030 FTAQTPAKAEVLMQPVEQNIKNM 4052 Score = 455 bits (1171), Expect = e-126, Method: Compositional matrix adjust. Identities = 399/1426 (27%), Positives = 649/1426 (45%), Gaps = 212/1426 (14%) Query: 37 EDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKPIVNNKAYADFMGARF 96 + +AI+GISC+ P A N ++W+++ KE E I+ A+ + Sbjct: 1090 DSVAIVGISCQFPGAKNHHDFWNHI-----------KEGKESIRFFSEEDVRANGVPEEL 1138 Query: 97 ISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAGDK 156 I + + + +E D FD F ISPK+A+ MDP R+LL W AIEDAGY + Sbjct: 1139 I--QHPDYVPVQSVIEGKDLFDPGFFQISPKDAEYMDPQLRLLLLHSWKAIEDAGYVAKE 1196 Query: 157 IYGSQTSLYVGKDHVNDTLYRYVTE-DESTSMTGNW----PGLMAGRINYLLNLKGNSMV 211 I + + + L + TE ES +W G + I++ L LKG S Sbjct: 1197 IPATSVYMSASSNSYRTLLPKETTEGHESPDGYVSWVLAQSGTIPTMISHKLGLKGPSYF 1256 Query: 212 LDSACSSGLLGVHLACNALKNKECEMAIVSAISLGIFPRFSTARKSMME-SQDDRVKTFD 270 + S CSS L+G++ A +L + E + A+V +L ++ + S D VK FD Sbjct: 1257 VHSNCSSSLVGLYQAYKSLTSGESQYALVGGATLHAQSAIGYVHQNGLNFSSDGHVKAFD 1316 Query: 271 KNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASN-GLTAPNAVAQEEV 329 +ADG +GVA ++LK A +DGD+IYA+++G +NNDGA G AP+ Q EV Sbjct: 1317 ASADGMAGGEGVAVILLKKAVDAVKDGDHIYAIMRGIGINNDGAEKAGFYAPSVKGQTEV 1376 Query: 330 LLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQFCGIGSVKANIG 389 + + +I P T+ YIEAHGTGTKLGDPIE+ L + ++TDK QFCGIGSVK NIG Sbjct: 1377 IQHVLDTTKIHPETVSYIEAHGTGTKLGDPIEMSALNKVYKQYTDKTQFCGIGSVKTNIG 1436 Query: 390 HTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPKSVLPRR 449 H +GLA IKV +S+ HN + +I+ EPN I F SP +V + K R Sbjct: 1437 HLDTAAGLAGCIKVAMSLYHNELAPTINCTEPNPDIKFESSPFYVVRERKSLEKHAGVHR 1496 Query: 450 AGINSFGFVGTNAHVVVEEAPDQA-ATSEAAGPEYEIFTVSAKTEHSLRQLIHQYAEFFR 508 A ++SFG GTNAH + E+ + + A +E G + I +SAK L+ + + Sbjct: 1497 AALSSFGLGGTNAHAIFEQYENISDAGAENEGNQPYIIPISAKNSERLQVYAKEMLSYIS 1556 Query: 509 QGTETNLS--NICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASNGLSDISGKGVYYD 566 Q + + S +I YT + GR R+ IV EE + ++ ++GK + Sbjct: 1557 QDEQRHFSLRDIAYTFQVGREAMDNRIVFIVNDLEEWKHQLEAF-------VTGKPLAEG 1609 Query: 567 CHKIGSDRKQVRDQGE---ITLSEHRKLNSKAGSLLEEIVNDTSGYLILNLAEICNLYVK 623 C QGE +T +E N++A + ++ L ++ ++ Sbjct: 1610 C-----------IQGEKTRMTSAEQLLGNAEADDMASSRISKE------ELRKLAEMWAN 1652 Query: 624 GAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWGEVKDRRSELEVSVKNISHPLIDQCLADS 683 G VEW +Y + K R +SLPTY F YW E + + HPL + Sbjct: 1653 GFHVEWRRLYPNIKPRRISLPTYPFAEERYWPE--SSTGAITTIEPSRLHPL-EHHNTSV 1709 Query: 684 MDETIYSTTFNVNTHWVLSDHKIMGVSVIPGTTYLEMGRKACSRLY-----HTDYLELRD 738 + E +S+ F + +++H I G++++P LEM R A + H + L++ Sbjct: 1710 LSEQRFSSIFT-GQEYFIAEHIIKGMAILPAAVTLEMARAAIEQGIGGLEDHETGIRLKN 1768 Query: 739 VFFFTPLSVGQTEDKQVHTIVKKEKGYTRFIIASQEQGKWITHAEGKAYNPADESKDAER 798 V + P+ G +E QV+ + E G H + Y ES DAE Sbjct: 1769 VVWVRPVVAG-SEPVQVNIGLYDEDG---------------GHIAYRMYGDP-ESADAEP 1811 Query: 799 LIFDLAAARNDSRKETIKVKYEDTSLSSKV--------------------FSFGPRWLNF 838 +++ N + E I++K E SK+ +GP + + Sbjct: 1812 VVY------NQGKAELIQLKREKALDLSKIKKQCDQSKMDAASFYEGMIGADYGPGYKSV 1865 Query: 839 KEVILDHNEQLVELELSEAFKGDLEELILHPSLLDNA-------ANVFIGEDDDDSTF-- 889 + V + L +L L E+ L + +LHPS++D A NV E D F Sbjct: 1866 EAVYKGDGQLLAKLSLPESVAHTLGDYVLHPSVMDGALQAAEYLQNVVRAELSDTEDFKA 1925 Query: 890 -LPLSYKNIKIYSAMPQHFYAYVQKKSGNKE---TKTCDIQLIDMQGRIFVEIKDYVLKK 945 LP + + ++++ + YVQ S NK + DI L D G I V +K + Sbjct: 1926 ALPFALEELEVFRQCVSDMWVYVQFNSKNKPGDLIQKVDIHLCDEHGMICVRLKGFS--- 1982 Query: 946 VNHLLTLFKENDDLSGAFYRLNWVQAEPAAEGRRGHEGTVLVFKDTQGIYENIAGPLQNK 1005 T E D +Q EP+ + + T+L+ Q +++ + K Sbjct: 1983 -----TRVMEAD-----------IQTEPS----KINAETLLL----QPVWQ------EQK 2012 Query: 1006 AADTIQVEFGEAYKRLTPNHYVIQGTENDYINLMNEIKDRNIRQI------LHLSSITGE 1059 AA+++ A K+ +++ + E +QI +H+ S+ E Sbjct: 2013 AANSL------AAKKYA-----------EHLVFLCEYDHETRKQIEAAIEDVHVYSL--E 2053 Query: 1060 AAATCADLADQQNRSLHSLFYLAKSISSNKIKENIDVVLISDNVTEVTGHEQEINPLGAA 1119 A + D + + +F + I K K+ I V + VT G +Q L + Sbjct: 2054 ARPSSVD--GRFHSYTEQVFKKVQEIIRTKPKDGILVQI----VTSAEGEQQ----LFSG 2103 Query: 1120 LFGLGTVLTQEFKNIHCRALDVDRETPAELISEEI--QRIESKYQVALRSGKRYTCELDR 1177 L GL QE + + ++V E E I+ ++ ++ S V ++G RY + R Sbjct: 2104 LTGLLKTACQENAKLTGQMIEVSSEESGESIAGKLLENQMSSDSYVKYQNGTRYIADW-R 2162 Query: 1178 HEPEHQEEQGLEIKEQGVYXXXXXXXXXXLEIARYLA--GKNAVHIALMNRSKLPEAASW 1235 + + + K+ GVY A+ +A KNA + L RS L E+ S Sbjct: 2163 EIKQAKGDGSKPWKDNGVYLISGGAGGLGHIFAKEIAEQTKNAT-VILAGRSPLSESKS- 2220 Query: 1236 DQLIQENPEHKLSRKLQAIKDIRESGSEVSCYSCDIADPDQVNEVVQDLKGKYGRIHGIF 1295 + +K++ G++++ D+ + +V +++ D++ +YGR++GI Sbjct: 2221 ----------------KKLKELHSKGADITYRQTDVTNKIEVYQLIDDIQKRYGRLNGIL 2264 Query: 1296 HCAGVAGEGFTFRKPKAVFNEVVSPKVTGTWILDQATREENLEFFILFSSINAIFGGSGQ 1355 H AG+ + + K ++V++PKV G LD+A+++ L+FFILFSS++ G GQ Sbjct: 2265 HSAGIIKDSYLVNKQAKDLHDVLAPKVKGLVYLDEASKDLPLDFFILFSSLSGSLGSIGQ 2324 Query: 1356 GDYTAANAYLDSFSYSRNK------RGARTISINWPAWSEVGIAAD 1395 DY AAN ++D ++ RN+ R +T+S+NWP W + G+ D Sbjct: 2325 SDYAAANVFMDMYAGYRNRLADLSQRHGQTLSVNWPLWRDGGMQVD 2370 Score = 449 bits (1156), Expect = e-124, Method: Compositional matrix adjust. Identities = 296/943 (31%), Positives = 467/943 (49%), Gaps = 80/943 (8%) Query: 35 KKEDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKPIVNNKAYADFMGA 94 K E IAI+G+S PKA + +EYW NL G DC E K+ + + ++ G Sbjct: 4075 KPEPIAIVGMSGVFPKAKDVEEYWKNLSSGADCITEVPKDRWD----------WQEYYGD 4124 Query: 95 RFISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAG 154 + E + K GG++++V FD F ISP EA+ M+P R+L+ W A+E+AG++ Sbjct: 4125 P-LKEANKTNVKWGGFIDEVADFDPLFFGISPLEAEQMEPQQRLLMTYAWKAVEEAGHSA 4183 Query: 155 DKIYGSQTSLYVGKDHVNDTLYRYVTEDESTSMTGNWPGLMAGRINYLLNLKGNSMVLDS 214 + G++T +++G + + + E ++ P R++Y LN+ G S +D+ Sbjct: 4184 RSLAGTKTGIFIGTGNTGYSSLLSNVDIEGSAAANMSPSAGPNRVSYFLNIHGPSEPIDT 4243 Query: 215 ACSSGLLGVHLACNALKNKECEMAIVSAISLGIFPRFSTAR-KSMMESQDDRVKTFDKNA 273 ACSS L+ +H A A++N CEMAI ++ + P+ A K+ S++ R KTF A Sbjct: 4244 ACSSSLVAIHHAVCAIENGNCEMAIAGGVNTVVTPQGHIAYDKAGALSKEGRCKTFSDKA 4303 Query: 274 DGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASNGLTAPNAVAQEEVLLKA 333 DG S+G + LK L+ A +DGD+IY VIKGSAVN+ G +N LT PN AQ +V+ A Sbjct: 4304 DGFAVSEGAGILFLKKLTAAERDGDHIYGVIKGSAVNHGGRANSLTTPNPKAQADVVKTA 4363 Query: 334 WEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDK-------AQFCGIGSVKA 386 +E A IDP T+ YIEAHGTGT+LGDP+EI GL AF + +K CG+GS K Sbjct: 4364 YEKAGIDPRTVTYIEAHGTGTELGDPVEINGLKAAFKELYEKTGDPAVHGSHCGLGSAKT 4423 Query: 387 NIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPK--- 443 NIGH +G+A +IKV+L +KH + S++ + N I SP ++ ++ +W Sbjct: 4424 NIGHLSLAAGVAGVIKVLLQLKHKTLVKSLYSETVNPYIRLDDSPFYIVQESREWQALRD 4483 Query: 444 ---SVLPRRAGINSFGFVGTNAHVVVEEAPDQAATSEAAGPEYE-----IFTVSAKTEHS 495 LPRRAGI+SFG G NAHVV+EE + T A P IF +SAK E Sbjct: 4484 EAGRELPRRAGISSFGIGGVNAHVVIEEYIPKETTHPATAPAVTAQHPGIFILSAKDEDR 4543 Query: 496 LRQLIHQYAEFF--RQGTETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASN 553 L+ Q A+F R T +L++I YT + GR RL +I S +L +K++ Sbjct: 4544 LKDQARQLADFISKRSITARDLTDIAYTLQEGRDAMEERLGIIAVSTGDLLEKLNLFIEG 4603 Query: 554 GLSDISGKGVYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLLEEIVNDTSGYLILN 613 G + K +Y + G + +R E+ + LN+ + E Sbjct: 4604 G---TNAKYMYRGRAEKGI-AQTLRSDDEV----QKTLNNSWEPHIYE------------ 4643 Query: 614 LAEICNLYVKGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYW-GEVKDRRSELEVSVKNIS 672 + +L+VKG ++ WS +Y + + +SLPTY F + YW + K+ + + ++K + Sbjct: 4644 --RLLDLWVKGMEIGWSKLYDGKQPKRISLPTYPFAKERYWITDTKEEAAAHQTALKTVE 4701 Query: 673 ----HPLIDQCLADSMDETIYSTTFNVNTHWVLSDHKIMGVSVIPGTTYLEMGRKACSRL 728 HPLI +D + E +S+ F + +DHK+ G V+PG YLEM A +R Sbjct: 4702 SAALHPLIHVNTSD-LSEQRFSSAFT-GAEFFFADHKVKGKPVMPGVAYLEMVHAAVTRA 4759 Query: 729 Y-----HTDYLELRDVFFFTPLSVGQTEDKQVHTIVKKEK----GYTRFIIASQEQGKWI 779 + +++V + P+ V + QV + ++ + + A+ K Sbjct: 4760 VRRTEDQQSVIHIKNVVWVQPI-VADGQPVQVDISLNPQQDGEIAFNVYTEAAHNDRK-- 4816 Query: 780 THAEGKAYNPADESKDAERLIFDLAAARNDSRKETIKVKYEDTSLSSKVFSFGPRWLNFK 839 H +G A + + D++A ++ T+ + +GP + Sbjct: 4817 IHCQGS----ASIRGAGDIPVQDISALQDQCSLSTLSHDQCYELFKAIGIDYGPGFQGID 4872 Query: 840 EVILDHNEQLVELELSEAFKGDLEELILHPSLLDNAANVFIG---EDDDDSTFLPLSYKN 896 + + N+ L EL L L E +LHPS+ D+A IG D+ LP + + Sbjct: 4873 RLYIGRNQALAELSLPAGVTHTLNEFVLHPSMADSALQASIGLKLNSGDEQLSLPFALQE 4932 Query: 897 IKIYSAMPQHFYAYVQKKSGNKETKTCDIQLIDMQGRIFVEIK 939 ++I+S + V + + + DI L D QGR+ V IK Sbjct: 4933 LEIFSPCTNKMWVSVTSRPNEDKIQRLDIDLCDEQGRVCVRIK 4975 Score = 63.9 bits (154), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 72/339 (21%), Positives = 140/339 (41%), Gaps = 31/339 (9%) Query: 1066 DLADQQNRSLHSLFYLAKS-ISSNKIKENIDVVLISDNVTEVTGHEQEINPLGAALFGLG 1124 ++ + Q++ + ++ L K+ +S ++ I +++ N V H+ ++P+ A + GL Sbjct: 5092 EMIEAQDQGVIQMYRLIKAMLSLGYGQKEISWTIVTVNTQYVDQHDI-VDPVDAGVHGLI 5150 Query: 1125 TVLTQEFKNIHCRALDVDR-ETPAELISEEIQRIESKYQVALRSGKRYTCEL---DRHEP 1180 +++E+ N + +DV + E + + A R+ + L ++P Sbjct: 5151 GSMSKEYPNWQTKLIDVKKYEDLPLSQLLSLPADQEGNTWAYRNKIWHKLRLIPVHNNQP 5210 Query: 1181 EHQEEQGLEIKEQGVYXXXXXXXXXXLEIARYLAGKNAVHIALMNRSKLPEAASWDQLIQ 1240 H + K GVY + Y+ I + R K D IQ Sbjct: 5211 VHTK-----YKHGGVYVVIGGAGGIGEAWSEYMIRTYQAQIVWIGRRKK------DAAIQ 5259 Query: 1241 ENPEHKLSRKLQAIKDIRESGSEVSCYSCDIADPDQVNEVVQDLKGKYGRIHGIFHCAGV 1300 KL R G D A+ +++ + +K + I+GI H A V Sbjct: 5260 S----KLDR-------FARLGRAPYYIQADAANREELERAYETMKQTHREINGIIHSAIV 5308 Query: 1301 AGEGFTFRKPKAVFNEVVSPKVTGTWILDQATREENLEFFILFSSINAIFGGSGQGDYTA 1360 + + F V++ KV + + Q R E L+F + FSS+ + SGQ +Y A Sbjct: 5309 LQDRSLMNMSEECFRNVLAAKVDVSVRMAQVFRHEPLDFVLFFSSVQSFARASGQSNYAA 5368 Query: 1361 ANAYLDSFSYSRNKRGARTISI-NWPAWSEVGIAA--DY 1396 ++ D+F+ ++ T+++ NW W +G+ + DY Sbjct: 5369 GCSFKDAFAQRLSQVWPCTVAVMNWSYWGSIGVVSSPDY 5407 >emb|CAB13603.2| polyketide synthase [Bacillus subtilis subsp. subtilis str. 168] Length = 4262 Score = 483 bits (1243), Expect = e-134, Method: Compositional matrix adjust. Identities = 309/954 (32%), Positives = 485/954 (50%), Gaps = 94/954 (9%) Query: 37 EDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKPIVNNKAYADFMGARF 96 EDIAIIG++ R PKA N E+W L G DC E E D + Sbjct: 394 EDIAIIGMAGRYPKAKNIQEFWEQLKAGTDCITEIPNSRWEW-----KESDGLDSPAGKP 448 Query: 97 ISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTAIEDAGYAGDK 156 +S K GG++E+ D FD + F ISP+EA+ MDP R+ LET W AIEDAGY + Sbjct: 449 LS-------KWGGFIEEADCFDPQFFRISPREAEMMDPQERLFLETCWEAIEDAGYTPET 501 Query: 157 IYGSQ-------TSLYVGKDHVNDTLY--RYVTEDESTSMTGNWPGLMAGRINYLLNLKG 207 I Q ++ G H + +L ++E ++ N+ +A R++Y N G Sbjct: 502 IASPQGENKRQHVGVFAGVMHKDYSLIGAEALSEHNPFPLSLNY-AQIANRVSYYCNFHG 560 Query: 208 NSMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLGIFPRFSTARKSM-MESQDDRV 266 SM +D+ CSS L VHLA +++N ECE A+ ++L + P + S+ M S D Sbjct: 561 PSMAVDTVCSSSLTAVHLAIESIRNGECEAALAGGVNLSLHPAKYISYGSVGMHSSDGYC 620 Query: 267 KTFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASNGLTAPNAVAQ 326 TF K DG +GV V+LKPL KA QDGD IYAVIKGSA+N+ G +G+T P+ VAQ Sbjct: 621 HTFGKGGDGYVSGEGVGTVLLKPLRKAEQDGDRIYAVIKGSAINHVGKVSGITVPSPVAQ 680 Query: 327 EEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQFCGIGSVKA 386 +V+ E IDP TI Y+EAHGTGT LGDPIE++GL AF+++T QFC IGSVK+ Sbjct: 681 ADVIEACLEKTGIDPRTISYVEAHGTGTSLGDPIEVQGLVKAFSRNTQDKQFCSIGSVKS 740 Query: 387 NIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPKSVL 446 NIGH A +G++ L K VL + H + S+H +E N + ++P FV + +W + Sbjct: 741 NIGHAEAAAGISGLTKTVLQLHHKTLVPSLHSEELNPYLKLDQTPFFVQHETKEWEQPSF 800 Query: 447 ---------PRRAGINSFGFVGTNAHVVVEEAPDQAATSEAAGPEYE--IFTVSAKTEHS 495 PRRAG++SFG G+NAH+++EE + SE + E + +SA+ + Sbjct: 801 TENGVDVTYPRRAGLSSFGASGSNAHLILEEYIPAESHSETILTKNEEIVIPLSARNKDR 860 Query: 496 LRQLIHQYAEFFRQGTETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASNGL 555 L+ + +F + + NL + YT + GR R A IVK ++L K+ A NG Sbjct: 861 LQAYALKLLDFLSE--DVNLLALAYTMQAGRVEMEERAAFIVKDIKDLTAKLRAFA-NGE 917 Query: 556 SDISGKGVYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLLEEIVNDTSGYLILN-- 613 +I G + K N +A L VN + LI + Sbjct: 918 EEIEG-----------------------CWTGRAKENQEAAGLAS--VNALNNNLIRDSE 952 Query: 614 LAEICNLYVKGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWGEVKDRRSELEVSVKNISH 673 + E+ +V+G +V W +Y D K +S+PTY F R YW V + ++ +V +I H Sbjct: 953 MMEMAKAWVQGKRVTWDDLYGDRKPLKISVPTYPFARERYWISVPEMKTS---TVNHILH 1009 Query: 674 PLIDQCLADSMDETIYSTTFNVNTHWVLSDHKIMGVSVIPGTTYLEMGRKACSRLY---- 729 PL+ + +D E +S+ F T + LSDH + G ++PG YLEM R+A + Sbjct: 1010 PLVHRNTSD-FTEQRFSSVF-TGTEFFLSDHVVQGQKILPGVAYLEMAREAAEKAAGDLD 1067 Query: 730 -HTDYLELRDVFFFTPLSVGQTEDKQVHT-IVKKEKGYTRFIIASQEQGK---WITHAEG 784 + L+D+ + P+++ ++E K++H + ++ G F I S + K H +G Sbjct: 1068 GEQRVVSLKDIVWVRPITI-ESEPKEIHIGLFPEDNGDISFDIYSSSEHKEEALTIHCQG 1126 Query: 785 KAYNPADESKDAERLIFDLAAARNDSRKETIKVKYEDTSLSSKVFSFGPRWLNFKEVILD 844 +A S +AE I +L++ + + +T+ + + +G + ++V + Sbjct: 1127 RAVI----SDEAETSILNLSSIQTECSLDTVTSEQCYAAFRKIGLDYGEGYQGIEKVYVG 1182 Query: 845 HNEQLVELELSEAFKGDLEELILHPSLLDNAANVFIG--------EDDDDSTFLPLSYKN 896 ++ L ++ L K D + LHPSL+D+A + +G + LP + + Sbjct: 1183 KDQLLAKISLPAFLKNDKQHFALHPSLMDSAFHATVGFIVSSVNAAGQAQTLSLPFALQE 1242 Query: 897 IKIYSAMPQHFYAYVQKKSGNK---ETKTCDIQLIDMQGRIFVEIKDYVLKKVN 947 + I+S P+ ++Y++ S +K + + DI L D GR+ V +K ++ ++ Sbjct: 1243 VDIFSPCPEKIWSYIRYSSDSKAENKVRKYDIDLCDENGRVCVRMKGASMRALD 1296 Score = 395 bits (1014), Expect = e-108, Method: Compositional matrix adjust. Identities = 229/650 (35%), Positives = 353/650 (54%), Gaps = 49/650 (7%) Query: 17 LTQEEAKQMLRELKSEGAKKEDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMI 76 L E +K+ +R++ E IAIIG+S R P+A + E W NL G C + E Sbjct: 3515 LEPEASKKSIRQVHDE-----PIAIIGMSGRFPQADSVHELWDNLKNGKSCISDIPGERR 3569 Query: 77 EHIKPIVNNKAYADFMGARFISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSH 136 + R + E + G +L+D+D+FD F ISPKEA++MDP Sbjct: 3570 D---------------WGRANRDPEKAVPRWGAFLKDIDRFDPLFFQISPKEAESMDPRQ 3614 Query: 137 RVLLETVWTAIEDAGYAGDKIYGSQTSLYVGKDHVNDTLYRYVTEDESTSMTGNWPGLMA 196 + LE W EDAGY GD+I G +YVG V + Y ++T D + + G ++ Sbjct: 3615 PIFLEEAWHTFEDAGYMGDRIKGKSCGVYVG---VEEGEYAHLTGD-TDYINGTQNATLS 3670 Query: 197 GRINYLLNLKGNSMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLGI-FPRFSTAR 255 RI Y L+LKG +M L +ACSSGL+ +H AC+AL+ +CEMA+ + ++L I F Sbjct: 3671 ARIAYALDLKGPNMALTAACSSGLVAIHQACSALRQGDCEMALAAGVTLNISHMSFEALT 3730 Query: 256 KSMMESQDDRVKTFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGAS 315 ++ M S + + K FD++A+G + VAAV+LKPLSKA +D D+IY IK S VN DG + Sbjct: 3731 RAEMLSPNGQCKVFDQDANGLVPGEAVAAVLLKPLSKAIEDKDHIYGCIKASGVNYDGKT 3790 Query: 316 NGLTAPNAVAQEEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDK 375 NG+TAPN +Q E++ +E +I+P IQY+ AH TG+ LGDP+E++ LT+ F+K+T + Sbjct: 3791 NGITAPNPFSQAELIENIYEKNEINPLDIQYVMAHSTGSNLGDPLEVQALTSVFSKYTKQ 3850 Query: 376 AQFCGIGSVKANIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVT 435 QFC I S+K IGHT A SG +LI ++++MK+ +IP++ H + N I F +SP + Sbjct: 3851 KQFCMISSIKPLIGHTFAASGTVALISMLMAMKNQIIPATHHCESENPYIPFKESPFVLC 3910 Query: 436 EKPLQW-PKSVLPRRAGINSFGFVGTNAHVVVEE-APDQAATSEAAGPEYEIFTVSAKTE 493 ++ W K+ PR I++ G GTNAH V+EE PD +++ +IF +SA+ + Sbjct: 3911 KENRSWIKKNQKPRMGTISTTGISGTNAHAVIEEYIPDDQPSTQRHQGSPQIFVISAQND 3970 Query: 494 HSLRQLIHQYAEFFRQGTETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASN 553 L+ + + Q +L ++ YT + GR RLA++ + E+L +K+ + Sbjct: 3971 DRLQDAACRMIAYLEQNHNLSLPDVAYTLQVGRKAMEARLAIVANNQEQLVRKLKE---- 4026 Query: 554 GLSDISGKGVYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLLEEIVNDTSGYLILN 613 Y + K G Q R T L + ++L+ + + N Sbjct: 4027 ----------YVEAMKNGGVSGQQRSL--YTGYTEGILEEQDEAVLQALAKER------N 4068 Query: 614 LAEICNLYVKGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWGEVKDRRSE 663 L I +VKG ++ W L++ + R+VSLP Y F R YW ++SE Sbjct: 4069 LENIAECWVKGYQIPWELLHDGDDVRMVSLPGYPFARERYWISSGTQQSE 4118 Score = 368 bits (944), Expect = e-100, Method: Compositional matrix adjust. Identities = 228/638 (35%), Positives = 341/638 (53%), Gaps = 55/638 (8%) Query: 27 RELKSEGAKKEDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKPIVNNK 86 +E + D+A+IGIS R P+A +++W+NL G +C E K+ + K Sbjct: 2310 KETPTNTLASRDVAVIGISGRYPQAETAEDFWNNLKEGRNCIEEIPKDRWDW-------K 2362 Query: 87 AYADFMGARFISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWTA 146 AY D + +E + K GG+++D+DKFD F ISP EA+ MDP R+ L+T + + Sbjct: 2363 AYYD----KEKGKEGSIYTKWGGFIKDMDKFDPLFFQISPLEAERMDPQERLFLQTAYAS 2418 Query: 147 IEDAGYAGDKIYGSQTSLYVGKDHVNDTLYRYVTEDESTSMTGNWPGLMAGRINYLLNLK 206 IEDAGY D + S+ +G ++ V + G W +A RI+YLLN + Sbjct: 2419 IEDAGYTPDSLCSSRK---IG-------VFAGVMNKNYPTGYGYWS--IANRISYLLNFQ 2466 Query: 207 GNSMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLGIFP-RFSTARKSMMESQDDR 265 G S+ +D+ACSS L +HLA ++ + + AI ++L + P + M S D Sbjct: 2467 GPSLAVDTACSSSLTAIHLALESIYSGSSDCAIAGGVNLVVDPVHYQNLSVMNMLSASDT 2526 Query: 266 VKTFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASNGLTAPNAVA 325 K+F +ADG +GV A++LKPL +A DGD+IY VIK SA+N+ G +NG T PN A Sbjct: 2527 CKSFGDDADGFVDGEGVGAIVLKPLQQAIADGDHIYGVIKASAINSGGKTNGYTVPNPHA 2586 Query: 326 QEEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQFCGIGSVK 385 Q +V+ +A E A I TI Y+EAHGTGT LGDPIEI GLT AF K T + QFC IGS K Sbjct: 2587 QAQVIKEAIERADIPARTISYLEAHGTGTALGDPIEIAGLTKAFEKDTQEKQFCAIGSSK 2646 Query: 386 ANIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQWPKSV 445 +NIGH + +G+A L K++ K+ I S+H + N I F +P V ++ +W + V Sbjct: 2647 SNIGHCESAAGIAGLTKILFQFKYGQIAPSLHAQRLNPNIEFSHTPFVVQQQLGEWKRPV 2706 Query: 446 L-----PRRAGINSFGFVGTNAHVVVEE-APDQAATSEAAGPEYEIFTVSAKTEHSLRQL 499 + PRRAG++SFG G+NAH+++EE P A + P + +SAK L++ Sbjct: 2707 IGGQEVPRRAGLSSFGAGGSNAHIILEEYIPRTGAQTPKDHPP-ALIVLSAKNMERLQEK 2765 Query: 500 IHQYAEFFRQG--TETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASNGLSD 557 Q +Q ET+L I YT +TGR RLA I +S E+LE+K++ N Sbjct: 2766 AEQLLTAIKQKRYCETDLIRIAYTLQTGREAMEERLAFIAESLEDLERKLNDFIEN---- 2821 Query: 558 ISGKGVYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLLEEIVNDTSGYLILNLAEI 617 +Y D +I ++K + LS + ++E ++ ++ Sbjct: 2822 -KADSLYLD--RIDDNKKAL-----AVLSA----DEDTEKIIEAWMSKG------KYTKL 2863 Query: 618 CNLYVKGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWG 655 +L+VKG +W ++Y +SLP Y F + YW Sbjct: 2864 LDLWVKGLSFDWGMLYGTQTPVRISLPAYPFAKERYWA 2901 Score = 97.4 bits (241), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 96/205 (46%), Gaps = 18/205 (8%) Query: 1189 EIKEQGVYXXXXXXXXXXLEIARYLAGKNAVHIALMNRSKLPEAASWDQLIQENPEHKLS 1248 ++K G Y A++LA A ++ L RS + Sbjct: 3140 KLKSGGTYLITGGVGGLGYLFAKHLAKNYAANLILTGRSPFND----------------- 3182 Query: 1249 RKLQAIKDIRESGSEVSCYSCDIADPDQVNEVVQDLKGKYGRIHGIFHCAGVAGEGFTFR 1308 K + IK++++ G E D++DP + + V+ K ++G I+G+ H AG+ + F Sbjct: 3183 EKQKQIKELKDLGGERMYAEADVSDPIAMGDCVKRGKDRFGAINGVIHAAGIESDSAIFD 3242 Query: 1309 KPKAVFNEVVSPKVTGTWILDQATREENLEFFILFSSINAIFGGSGQGDYTAANAYLDSF 1368 K F ++ PK+ GT LD+ + E+L+F FSS +A+ G G DY N + ++ Sbjct: 3243 KKIESFQRIIEPKINGTIALDEWLKNEDLDFMCYFSSSSAVLGDFGCCDYAIGNRFQMAY 3302 Query: 1369 SYSRNK-RGARTISINWPAWSEVGI 1392 + RN+ +T INWP W + G+ Sbjct: 3303 AQYRNELHNGKTFVINWPVWKDGGM 3327 Score = 64.7 bits (156), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 73/339 (21%), Positives = 140/339 (41%), Gaps = 39/339 (11%) Query: 1068 ADQQNRSLHSLFYLAKS-ISSNKIKENIDVVLISDNVTEVTGHEQEINPLGAALFGLGTV 1126 +D Q ++ LF L K+ + ++ ++ L++ VT HE + P A++ GL Sbjct: 1399 SDGQEEAVLHLFKLVKACLQLGYGEKQLEWSLVTVQAQPVTQHEA-VQPAHASIHGLAGT 1457 Query: 1127 LTQEFKNIHCRALDVDRETPAELISEEIQRIESKYQVALRSGKRYTCELDRHEPEHQEE- 1185 + +E+ + R LD+++ + + AL + + R++ HQ++ Sbjct: 1458 MAKEYPHWKIRLLDLEKGCTWPV----------NHMFALPADRLGHAWAYRNQQWHQQQL 1507 Query: 1186 -------QGLEI-KEQGVYXXXXXXXXXXLEIARYLAGKNAVHIALMNRSKLPEAASWDQ 1237 G + ++ GVY + Y+ + I + RS+L A Sbjct: 1508 IPYRSSLSGDTLYRKGGVYVVIGGAGYIGEAWSEYMIRRYQAQIVWIGRSQLNAAI---- 1563 Query: 1238 LIQENPEHKLSRKLQAIKDIRESGSEVSCYSCDIADPDQVNEVVQDLKGKYGRIHGIFHC 1297 + K+ R L A+ G E + D AD + + + +K ++ IHGI H Sbjct: 1564 ------QSKIDR-LSAL------GPEPFYIAADAADKHSLQQAYEQVKKRHPHIHGIVHS 1610 Query: 1298 AGVAGEGFTFRKPKAVFNEVVSPKVTGTWILDQATREENLEFFILFSSINAIFGGSGQGD 1357 A V E + F ++ K+ + + Q R+EN++F + FSS+ A Q Sbjct: 1611 AMVLFEQSLEKMKPEEFTAGLAAKIDVSIRMAQVFRQENVDFVLFFSSLVAHIKNVKQSH 1670 Query: 1358 YTAANAYLDSFSYSRNKRGARTISI-NWPAWSEVGIAAD 1395 Y + + D+F++ ++ A + + NW W A D Sbjct: 1671 YASGCTFADAFAHQLSQSWACPVKVMNWGYWGNSEAAED 1709 >pir||T44806 mycosubtilin synthetase chain mycA [imported] - Bacillus subtilis gb|AAF08795.1| MycA [Bacillus subtilis] Length = 3971 Score = 478 bits (1229), Expect = e-133, Method: Compositional matrix adjust. Identities = 270/658 (41%), Positives = 383/658 (58%), Gaps = 47/658 (7%) Query: 30 KSEGAKKEDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQ----KEMIEHIKPIVNN 85 K + +DIAIIG+S +P ASN ++W L G E+ K+ I++++ I + Sbjct: 663 KPSRSSSKDIAIIGMSLNVPGASNKSDFWHLLENGEHGIREYPAPRVKDAIDYLRSIKSE 722 Query: 86 KAYADFMGARFISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLETVWT 145 + F+ GGYL+++D+FD F ++PK AK MDP+ R+ L++ W Sbjct: 723 RNEKQFV--------------RGGYLDEIDRFDYSFFGLAPKTAKFMDPNQRLFLQSAWH 768 Query: 146 AIEDAGYAGDKIYGSQTSLYVGKDHVNDTLYRYVT----EDESTSMTGNWPGLMAGRINY 201 AIEDAGYAGD I GSQ +YVG V R ++ E+ + GN P ++A RI Y Sbjct: 769 AIEDAGYAGDTISGSQLGVYVGYSKVGYDYERLLSANYPEELHHYIVGNLPSVLASRIAY 828 Query: 202 LLNLKGNSMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLGIFPRFSTARKSM-ME 260 LNLKG ++ +D+ACSS L+ VH+AC AL +CEMA+ I + P R + ME Sbjct: 829 FLNLKGPAVTVDTACSSSLVAVHMACKALLTGDCEMALAGGIRTSLLP----MRIGLDME 884 Query: 261 SQDDRVKTFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASNGLTA 320 S D KTF K++DGT +GVAAV+LKPL A +DGD+IY VIKGSA+N DG + G+TA Sbjct: 885 SSDGLTKTFSKDSDGTGSGEGVAAVLLKPLQAAIRDGDHIYGVIKGSAINQDGTTVGITA 944 Query: 321 PNAVAQEEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQFCG 380 P+ AQ EV+ AW+DA I P T+ +IEAHGTGTKLGDP+E GL AF K T+K QFC Sbjct: 945 PSPAAQTEVIEMAWKDAGIAPETLSFIEAHGTGTKLGDPVEFNGLCKAFEKVTEKKQFCA 1004 Query: 381 IGSVKANIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEKPLQ 440 IGSVKANIGH +G+ LIK L + H IP HF +PN LI F SP +V ++ + Sbjct: 1005 IGSVKANIGHLFEAAGIVGLIKSALMLNHKKIPPLAHFNKPNPLIPFHSSPFYVNQEVMD 1064 Query: 441 WPKSVLPRRAGINSFGFVGTNAHVVVEEAPDQAATSEAAGPEYEIFTVSAKTEHSLRQLI 500 + P R GI+SFGF GTNAHVV+EE ++ + G + +F +SA TE SL +L Sbjct: 1065 FTPEDRPLRGGISSFGFSGTNAHVVLEEYTPESEYAPEDGNDPHLFVLSAHTEASLYELT 1124 Query: 501 HQYAEFFRQGTETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASNGLSDISG 560 HQY ++ ++++L +ICYTA TGR H Y LA+IV S +EL K++ L I G Sbjct: 1125 HQYRQYISDDSQSSLRSICYTASTGRAHLDYCLAMIVSSNQELIDKLTSL-------IQG 1177 Query: 561 KGVYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLLEEIVNDTSGYLILNLAEICNL 620 + + ++ K ++ E+ +E L+ + L++ T I L I L Sbjct: 1178 E---RNLPQVHFGYKNIK---EMQPAEKDNLSKQISDLMQH-RPCTKDERITWLNRIAEL 1230 Query: 621 YVKGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWGE-----VKDRRSELEVSVKNISH 673 YV+ A ++W +Y + + LP Y F+R W E K+R+ + EV++ +I+H Sbjct: 1231 YVQRAVIDWRAVYSNEVVQKTPLPLYPFERNRCWVEAVYESAKERKEKGEVAL-DINH 1287 >dbj|BAB69698.1| iturin A synthetase A [Bacillus subtilis] Length = 3982 Score = 469 bits (1208), Expect = e-130, Method: Compositional matrix adjust. Identities = 262/646 (40%), Positives = 373/646 (57%), Gaps = 41/646 (6%) Query: 28 ELKSEGAKK------EDIAIIGISCRLPKASNTDEYWSNLMGGLDCKVEFQKEMIEHIKP 81 E+K + A K +DIAIIG+S +P AS ++W+ L G E+ + + Sbjct: 654 EIKQDAAAKPSHVTPKDIAIIGMSLNVPGASTKSDFWNLLEKGEHSIREYPESRL----- 708 Query: 82 IVNNKAYADFMGARFISEEEAEDCKMGGYLEDVDKFDAELFNISPKEAKAMDPSHRVLLE 141 K AD++ + E++ K GGYL+++D+FD F ++PK A+ MDP+ R+ L+ Sbjct: 709 ----KDAADYLKSIQSEFNESQFVK-GGYLDEIDRFDYSFFGLAPKTAQFMDPNQRLFLQ 763 Query: 142 TVWTAIEDAGYAGDKIYGSQTSLYVGKDHVNDTLYRYVT----EDESTSMTGNWPGLMAG 197 + W AIEDAGYAG + GS+ +Y G V R ++ E+ + GN P ++A Sbjct: 764 SAWHAIEDAGYAGGSMNGSRVGVYAGYSKVGYDYERLLSANYPEELHQYIVGNLPSVLAS 823 Query: 198 RINYLLNLKGNSMVLDSACSSGLLGVHLACNALKNKECEMAIVSAISLGIFPRFSTARKS 257 RI Y LNLKG ++ +D+ACSS L VH+AC +L + +CEMA+ I + P Sbjct: 824 RIAYFLNLKGPAVTVDTACSSSLAAVHMACKSLMSGDCEMALAGGIRTSLLP---ICIGL 880 Query: 258 MMESQDDRVKTFDKNADGTFFSDGVAAVILKPLSKARQDGDNIYAVIKGSAVNNDGASNG 317 MES D KTF K++DGT +G AAV+LKPL A +DGD+IY VIKGSA+N DG + G Sbjct: 881 DMESSDGYTKTFSKDSDGTGTGEGAAAVLLKPLQDAVRDGDHIYGVIKGSAMNQDGTTAG 940 Query: 318 LTAPNAVAQEEVLLKAWEDAQIDPGTIQYIEAHGTGTKLGDPIEIKGLTNAFAKHTDKAQ 377 +TAPN AQ EV+ AW+DA I P T+ +IEAHGTGTKLGDP+E GL AF K+T K Q Sbjct: 941 ITAPNPAAQTEVIETAWKDAGIAPETLSFIEAHGTGTKLGDPVEFNGLCKAFEKYTAKKQ 1000 Query: 378 FCGIGSVKANIGHTVAVSGLASLIKVVLSMKHNVIPSSIHFKEPNSLINFIKSPVFVTEK 437 FC IGSVK+NIGH +G+ LIK VL + H P HF EPN LI+F SP +V ++ Sbjct: 1001 FCAIGSVKSNIGHLFEAAGIVGLIKSVLMLNHKKNPPLAHFNEPNPLIHFHSSPFYVNQE 1060 Query: 438 PLQWPKSVLPRRAGINSFGFVGTNAHVVVEEAPDQA--ATSEAAGPEYEIFTVSAKTEHS 495 ++ P R G++SFGF GTNAHVV+EE Q+ A + GP +F +SA TE S Sbjct: 1061 AAEFTSGDEPLRGGVSSFGFSGTNAHVVLEEYISQSEYAPEDEHGP--HLFVLSAHTEKS 1118 Query: 496 LRQLIHQYAEFFRQGTETNLSNICYTAKTGRGHYAYRLALIVKSYEELEQKISKLASNGL 555 L +L QY ++ ++ +L +ICYTA TGR H + +A+IV +EL K+++L Sbjct: 1119 LYELAQQYRQYVSDDSQASLKSICYTASTGRAHLDHGIAMIVSGKQELSDKLTRLIQ--- 1175 Query: 556 SDISGKGVYYDCHKIGSDRKQVRDQGEITLSEHRKLNSKAGSLLEEIVNDTSGYLILNLA 615 D + GVY IG ++ E+ + +LN +A +L+++ + T I L Sbjct: 1176 GDRNLPGVY-----IG-----YKNMKEMLPAHKEELNQQAAALIKQRLR-TQDERITWLH 1224 Query: 616 EICNLYVKGAKVEWSLMYRDNKRRIVSLPTYQFDRVMYWGEVKDRR 661 L+V+GA ++W +Y + LP Y F+R W E R Sbjct: 1225 RAAELFVQGAVIDWRALYSGETVQKTPLPLYPFERSRCWAEADQLR 1270 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.316 0.133 0.380 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 2,344,100,316 Number of extensions: 100679138 Number of successful extensions: 286961 Number of sequences better than 1.0e-05: 2003 Number of HSP's gapped: 279807 Number of HSP's successfully gapped: 3179 Length of query: 1606 Length of database: 757,237,578 Length adjustment: 139 Effective length of query: 1467 Effective length of database: 379,838,817 Effective search space: 557223544539 Effective search space used: 557223544539 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 133 (55.8 bits)