BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0382.0026.p (2232 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value sp|O68007|BACB_BACLI Bacitracin synthetase 2 (BA2) [Includes: AT... 1114 0.0 sp|O68006|BACA_BACLI Bacitracin synthetase 1 (BA1) [Includes: AT... 1110 0.0 sp|O30408|TYCB_BREPA Tyrocidine synthetase II [Includes: ATP-dep... 1092 0.0 sp|O68008|BACC_BACLI Bacitracin synthetase 3 (BA3) [Includes: AT... 1074 0.0 emb|CAE02631.1| surfactin synthetase B [Bacillus amyloliquefaciens] 1045 0.0 >sp|O68007|BACB_BACLI Bacitracin synthetase 2 (BA2) [Includes: ATP-dependent lysine adenylase (LysA) (Lysine activase); ATP-dependent D-ornithine adenylase (D-OrnA) (D-ornithine activase); Ornithine racemase ] pir||T31678 bacitracin synthetase 2 bacB [imported] - Bacillus licheniformis gb|AAC06347.1| bacitracin synthetase 2; BacB [Bacillus licheniformis] Length = 2607 Score = 1114 bits (2881), Expect = 0.0, Method: Compositional matrix adjust. Identities = 602/1550 (38%), Positives = 889/1550 (57%), Gaps = 14/1550 (0%) Query: 675 VWGAVLGMNPMSVTADFYEIGGDSIIAIEIVNTLNTIMGLSLQVPVLFEHSNIERLAAYI 734 +W +L + + F++IGG S+ A + + + + + + + +F HS I+ LAAYI Sbjct: 1028 IWQDILPAEQIGINDHFFDIGGHSLKAFSMAAKIQSALKVEVTLKEIFNHSTIQDLAAYI 1087 Query: 735 EGQAGTDKDTRGNSAIPRIAAAEHYEVSSSQKRIYILNQLNARSTSYNIPLFVMMEGPLD 794 K + S I + E+Y +SS+QKR+YILNQ+ T+YN+P + ++G L Sbjct: 1088 -----AQKQKQVQSDIQKAEKKEYYPLSSAQKRLYILNQIEEGQTAYNMPFAMKIKGELQ 1142 Query: 795 EGRLEHSFEALIQRHEVLRTSFSFVNKELVQAVDDHVHLAVEKYHADDETDLDQITSQFI 854 + E +F LI+RHE RTSF +N E VQ +++ V + KY D L + +QFI Sbjct: 1143 TDKAEKAFRTLIKRHESSRTSFVTINGEPVQNINEEVTFEM-KYRELDNCSLRERMNQFI 1201 Query: 855 RPFDLSKAPLIRAGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYEHNPLPELNI 914 RPF+L KAPL+RA LV + +H+L+LD+ HII+DG SI +L KE LYE L L I Sbjct: 1202 RPFELEKAPLLRAELVRVNAAEHILLLDMHHIISDGVSIGILMKEWAALYEEKELAPLKI 1261 Query: 915 QFKDFAKWQNDLFKTDYMNKQKKYWLDVFSGELPILNLPVDYPRDSGQGDQGERLTCNAG 974 Q+KD+++WQ D ++ D + KQ++ WL VF ++P+LN+P D+PR Q +G+R+ Sbjct: 1262 QYKDYSEWQRDPWQKDRLKKQEESWLSVFQNDIPVLNMPTDFPRPQMQSYEGDRIAFAIE 1321 Query: 975 RELTQRLNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHKELEQMIGMF 1034 RELT +L + + + T++M LLA + +LL K+TGQEDIIVGSPIAGR +ELEQ +GMF Sbjct: 1322 RELTDKLKKTAKENGVTMYMLLLAGYTILLSKYTGQEDIIVGSPIAGRTREELEQTVGMF 1381 Query: 1035 VNTLALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNLSGTALFNVM 1094 V TLA+RN P F E+L VKEN AYE+QDYPF+ELVD L+++R++S ALF+ M Sbjct: 1382 VGTLAMRNHPKGGRTFIEYLQDVKENTFNAYENQDYPFDELVDKLDLERDISRNALFDTM 1441 Query: 1095 FVLQVMDNPAFEVNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAAKLFKRSTIE 1154 F +Q +D+ ++ G+H P + +KFDL+L + F + +L+K+ T E Sbjct: 1442 FDMQALDDAEPDIEGLHVEPVDLEFQISKFDLSLTAAESAGVITFHLEFCTRLYKKETAE 1501 Query: 1155 SFARRFLRVLEQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAYNTKTIVEMFEAQA 1214 + A+ F+ +L + + DI +L EE R Y + + E+FE QA Sbjct: 1502 TLAQHFVNILRDISDHPQKTLNDISMLSEEE-RHTVLYQFNDTNTEHPSGIFSELFEEQA 1560 Query: 1215 ARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERSTNFAVGIMGV 1274 + P+H A D+ LTYRELNE+ANQLAR L + G ++ VVGI+AERS GI+ V Sbjct: 1561 EKSPNHPAAVFKDQMLTYRELNEKANQLARTLRQKGVQRESVVGIMAERSLEMLTGILAV 1620 Query: 1275 LKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLEEVAGNSGEQ 1334 LK+G AY+PI+P P ER ++++ DSGA ++LT S+ I +++ + Sbjct: 1621 LKAGGAYMPIDPGLPKERIQYLITDSGADLLLTQHQLIGSISFAGEIIQIDQADAYDTDG 1680 Query: 1335 GNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKIYSLHGPNLNVALLA 1394 NLE S LAYVIYTSG+TG PKGVM+EHR++ + A K Y L ++N+ LA Sbjct: 1681 SNLEHLNSPGDLAYVIYTSGTTGNPKGVMVEHRNIIH-AHYTWRKHYELASFSVNLLQLA 1739 Query: 1395 PFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPAYLRLLAET 1454 FD + + L G + IVP DV+ ++ L + + I + + TP+ + L + Sbjct: 1740 SMSFDVFAGDLCRSLLNGGTMYIVPDDVKLEMNLLYDMINKYGIHMLESTPSLIIPLMKY 1799 Query: 1455 SLCARIGVAH---FIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPTECCVDATAFTIK 1511 ++ + I+G + +I + K F I N YG TE VD+ + Sbjct: 1800 IDHHKLDFSSMKLLIMGSDTCTIKDYKWLVERFGQRM--RIINSYGVTEASVDSGYYEEA 1857 Query: 1512 PEETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYCNNKALTSSR 1571 + +I PIG P+ N + YILD P GV GELYIGG G+ARGY N LT R Sbjct: 1858 LDRIPEIANTPIGKPLDNTAFYILDPSLNPQPVGVYGELYIGGEGIARGYLNKPELTKER 1917 Query: 1572 FVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHRLLSCDGVQ 1631 FV + + G MYKTGD+ +W DG + F GR DHQVKIRGFRIE EI +LL + Sbjct: 1918 FVPNRFAAGGNMYKTGDLARWLPDGNVEFLGRIDHQVKIRGFRIETGEIETKLLENQNIS 1977 Query: 1632 AAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMPVDQIPMTANG 1691 AVV+ ++D++ YLCAY+V R + LR YL ++LPDYM+P + ++++P+T NG Sbjct: 1978 EAVVIDREDKKGHKYLCAYIVARAKTNTNELREYLSDHLPDYMLPSYFIQINKMPLTPNG 2037 Query: 1692 KADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFAAGGDSIKA 1751 K D LP+P + GY APRN TEE L VW EVL+ +IGI+DNFF GGDSIKA Sbjct: 2038 KIDRKALPEPAGDVIAASGYEAPRNETEEKLAAVWQEVLDRDKIGINDNFFEIGGDSIKA 2097 Query: 1752 IQAAARMEKYNLRLEVKHLFQYQTIGEVSKKVQDRAGHAGYGAVTGEAGLVPIQSWMVEH 1811 +Q +++ + +L+L+VK LF I +SK V+ V G+ L P+Q E Sbjct: 2098 LQIVSKLSRADLKLQVKDLFTNPFIRHLSKYVKKETKARTSEIVQGQVPLTPVQRSFFEA 2157 Query: 1812 CRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALRMVFREQNRQMLQHNRGLDGE 1871 + H N +F+LYRE GF E + KVF ++ HHDALRMV+ E+N ++QHNRGL+ Sbjct: 2158 NQREQNHYNQAFMLYRENGFAERIVEKVFRKLTEHHDALRMVYWEKNGDIIQHNRGLEDS 2217 Query: 1872 LFDFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKGPLVKLALIRAGYGEHLLIVIHQMII 1931 +FD Y+ DL + + + + +G ++KL + + G+HLLI IH +++ Sbjct: 2218 VFDLYVYDLKTEKNLEKTVYQIATNIQKDISISEGKMIKLCVFKTTEGDHLLIAIHHLLV 2277 Query: 1932 DHLSWRIILEDFNTAYTQLLNHEDIGLPPKTAPFLQWSNHLHEYADSIELLREQPYWDQV 1991 D +SWRI+ EDF AY Q L + I L KT + +S L EYA+S +LL+EQ YW ++ Sbjct: 2278 DGVSWRILFEDFEAAYGQALQGKPIELGYKTDSYKTFSEKLAEYANSKKLLKEQEYWREI 2337 Query: 1992 ESIKAEPLPTDYKADEARVRDNLTLYQAFDCTETEQVMSSIRSNPHFTTESIMLTALALT 2051 K LP +A ++ TL + TETEQ++ + ++LTAL + Sbjct: 2338 SKGKMAFLPKHRQAAHDNYENSRTLRISLSQTETEQLLKEAHKAYNTQINDLLLTALLIA 2397 Query: 2052 IRAWTGNAAVVVNLGNHGRDMDSKDIDTYRTVGRFSILYPVALQLPESRNIDLCLEYVKE 2111 R TG + + + HGRD +D+D RTVG F+ +YPV + L + ++ + ++ VKE Sbjct: 2398 SRQLTGENRLKILMEGHGRDDILQDVDITRTVGWFTAMYPVFIDLEDEADLSVMIKIVKE 2457 Query: 2112 YLSGIPKQGGGYGVLKYLSSHQEGIRFRLNPELSFNYMGQFDAEFNTSTFRISPLSGGED 2171 L IP G GYG+LKYL EG+ P + FNY+G+ D + T F S LS G+ Sbjct: 2458 TLRKIPNNGIGYGILKYLRK-DEGLLKDEKPPILFNYLGELDHDLTTEQFSSSKLSAGQS 2516 Query: 2172 RSGEEIWSYKLKFISFIRMNQLNIGIEYNQQQYARETVNALLQQYMEYLK 2221 + ++ S + QL I +N+ +Y+ +T++ L Q + E L+ Sbjct: 2517 IGEKSARDASVEIDSVVAGRQLMISTTFNEYEYSPDTISELNQAFKESLQ 2566 Score = 801 bits (2068), Expect = 0.0, Method: Compositional matrix adjust. Identities = 483/1356 (35%), Positives = 746/1356 (55%), Gaps = 56/1356 (4%) Query: 749 AIPRIAAAEH--YEVSSSQKRIYILNQLNARSTSYNIPLFVMMEGPLDEGRLEHSFEALI 806 + P+ A ++ Y +S QKR++ILNQL+ T+YN+PL V + G + RLE +++ALI Sbjct: 64 SFPKAAPSKSGTYPLSREQKRMFILNQLDDSKTAYNMPLAVKINGEVQISRLEQAWKALI 123 Query: 807 QRHEVLRTSFSFVNKELVQAVDDHVHLAVEKYHADDETDLDQITSQFIRPFDLSKAPLIR 866 +RHE LRTSF ++ E VQ ++ +E D++ ++I S+FI+PF+L KAPL+R Sbjct: 124 KRHESLRTSFVMLDGEPVQKIEQEAEFRLEYSELGDQSIQEKI-SRFIKPFELEKAPLLR 182 Query: 867 AGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYEHNPLPELNIQFKDFAKWQNDL 926 A +V++ + +H++M+D+ HII+DG SI +L KE E L L +Q+KD+++WQ D+ Sbjct: 183 AEIVKVDEAEHMMMVDMHHIISDGVSIGILMKEFADCCEGKELSPLAVQYKDYSEWQRDI 242 Query: 927 FKTDYMNKQKKYWLDVFSGELPILNLPVDYPRDSGQGDQGERLTCNAGRELTQRLNEYSS 986 + + KQ+ YWL+ F G++P+LN+P+D+PR + QG R ++ T++L ++ Sbjct: 243 EQQSRLKKQEAYWLNTFRGDIPVLNMPLDFPRPKIRSFQGNRTVVELDQDTTKKLKTIAA 302 Query: 987 KEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHKELEQMIGMFVNTLALRNRPSA 1046 K T++M LLA + +LL K+TGQEDIIVGSPIAGR H +L IGMFV TLALRNRP Sbjct: 303 KNGVTMYMLLLAGYTILLSKYTGQEDIIVGSPIAGRPHADLNGTIGMFVGTLALRNRPKG 362 Query: 1047 HMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNLSGTALFNVMFVLQVMDNPAFE 1106 +M F E++ VK N L+AYE+QDY F+ L++HL + ++S LF+ MF LQ D+ A E Sbjct: 363 NMTFSEYVQTVKNNTLKAYENQDYQFDALIEHLGLTHDMSRNPLFDTMFDLQHADDFASE 422 Query: 1107 VNGMHYAPY--PYHNKTAKFDLALQVFPGLDELKFEFTYAAKLFKRSTIESFARRFLRVL 1164 G H+ Y P+H AKFD++L F D LKF+F Y L+K+ T+E A FL VL Sbjct: 423 AGGGHFETYDIPFH--VAKFDVSLTAFLHGDNLKFDFQYCTDLYKKETVERMAGHFLNVL 480 Query: 1165 EQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAYNTKTIVEMFEAQAARIPDHLAVS 1224 + + + +I ++ EE I KT+ +FE +A + PDH AV Sbjct: 481 KDAAHHPELALSEIRMMSEEEKDIILHTFNHEKTDGPKNKTLSRLFEERAEKTPDHTAVI 540 Query: 1225 GFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERSTNFAVGIMGVLKSGAAYLPI 1284 D+ LTYRELNE+ANQLA +L G D +V I+ +RS +GI+G+LK+G AYLPI Sbjct: 541 FEDQQLTYRELNEKANQLAWLLREKGVKPDTIVAIMTDRSLEMIIGIIGILKAGGAYLPI 600 Query: 1285 EPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLEEVAGNSGEQGNLEATASAD 1344 +P YP +R ++MLEDSGA MV+ + + G + I E+ S E NL A Sbjct: 601 DPDYPEDRVKYMLEDSGADMVVIQEPFKSKID-GRQLITAEDTRSFSKE--NLPNVNKAS 657 Query: 1345 SLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKI-YSLHGPNLNVALLAPFVFDASVK 1403 LAYVIYTSGS+G+PKGVM HR+V + +A ++I S H L V F FDA + Sbjct: 658 DLAYVIYTSGSSGRPKGVMTTHRNVVHYVDAFTKRIPLSEHDTVLQV---VSFSFDAFSE 714 Query: 1404 QIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPAYLRLLAETSLCARIGVA 1463 +++ L I ++ +L + + ++ + +P L + + Sbjct: 715 EVYPILACSGRLVISRKVSDLNIDELVKTIGKYRVTLVSCSPLLLNEIDKNQHLTFHPQM 774 Query: 1464 HFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPTECCVDATAFTIKPEETGQIQEMPI 1523 FI GG+ L V+ K + N YGPTE V AT + + + + +PI Sbjct: 775 KFISGGDVLKFEYVENII------KGADVYNSYGPTEATVCATYYQLSSADRKKTS-IPI 827 Query: 1524 GAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYCNNKALTSSRFVEDIYHPGMYM 1583 G P+ N VYI D+ R P GV GEL IGG GVARGY N++ LT + FV D G + Sbjct: 828 GKPLSNYKVYIADQYGRPQPVGVPGELLIGGEGVARGYLNHETLTKAAFVVD--ESGERV 885 Query: 1584 YKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHRLLSCDGVQAAVVLVQKDQRQ 1643 Y+TGD+ +W DG I F GR D QVKIRG+RIEL+EI HRLL D + A+V+ ++DQ Sbjct: 886 YRTGDLARWLSDGNIEFLGRIDSQVKIRGYRIELEEIEHRLLMNDNINEAIVVAKEDQEN 945 Query: 1644 EPYLCAYVVCRDEQV-LPGLRGYLGEYLPDYMIPRVIMPVDQIPMTANGKADTSQLPDPQ 1702 YLCAY+ ++ + ++ L + LP+YMIP + +DQIP T NGKAD LP+P Sbjct: 946 SKYLCAYIAFNNKNADIEQVQERLAKDLPEYMIPSCFIKLDQIPRTINGKADLKALPEPD 1005 Query: 1703 EMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFAAGGDSIKAIQAAARMEKYN 1762 Y APRN+TE +L ++W ++L +IGI+D+FF GG S+KA AA+++ Sbjct: 1006 RRAFAQARYEAPRNQTEALLLSIWQDILPAEQIGINDHFFDIGGHSLKAFSMAAKIQS-A 1064 Query: 1763 LRLEV--KHLFQYQTIGEVSKKVQDRAGHAGYGAVTGEAG-LVPIQS-----WMVEHCRD 1814 L++EV K +F + TI +++ + + E P+ S +++ + Sbjct: 1065 LKVEVTLKEIFNHSTIQDLAAYIAQKQKQVQSDIQKAEKKEYYPLSSAQKRLYILNQIEE 1124 Query: 1815 TLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALRMVFREQNRQMLQHNRGLDGEL-F 1873 N+ F + + D K F +I+ H++ R F N + +Q+ ++ E+ F Sbjct: 1125 GQTAYNMPFAMKIKGELQTDKAEKAFRTLIKRHESSRTSFVTINGEPVQN---INEEVTF 1181 Query: 1874 DFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKGPLVKLALIRAGYGEHLLIV-IHQMIID 1932 + +L D+ S E +LEK PL++ L+R EH+L++ +H +I D Sbjct: 1182 EMKYREL-DNCSLRER----MNQFIRPFELEKAPLLRAELVRVNAAEHILLLDMHHIISD 1236 Query: 1933 HLSWRIILEDFNTAYTQLLNHEDIGLPPKTAPFLQWSNHLHEYADSIELLREQPYWDQV- 1991 +S I+++++ Y E+ L P + +S + L +++ W V Sbjct: 1237 GVSIGILMKEWAALY------EEKELAPLKIQYKDYSEWQRDPWQKDRLKKQEESWLSVF 1290 Query: 1992 -ESIKAEPLPTDYKADEARVRDNLTLYQAFDCTETEQVMSSIRSNPHFTTESIMLTALAL 2050 I +PTD+ + + + + A + T+++ + + N T ++L + Sbjct: 1291 QNDIPVLNMPTDFPRPQMQSYEGDRIAFAIERELTDKLKKTAKEN-GVTMYMLLLAGYTI 1349 Query: 2051 TIRAWTGNAAVVVNLGNHGRDMDSKDIDTYRTVGRF 2086 + +TG ++V GR + + +TVG F Sbjct: 1350 LLSKYTGQEDIIVGSPIAGRTREELE----QTVGMF 1381 >sp|O68006|BACA_BACLI Bacitracin synthetase 1 (BA1) [Includes: ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); ATP-dependent cysteine adenylase (CysA) (Cysteine activase); ATP-dependent leucine adenylase (LeuA) (Leucine activase); ATP-dependent glutamate adenylase (GluA) (Glutamate activase); ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); Glutamate racemase ] pir||T31677 bacitracin synthetase 1 - Bacillus licheniformis gb|AAC06346.1| bacitracin synthetase 1; BacA [Bacillus licheniformis] Length = 5255 Score = 1110 bits (2872), Expect = 0.0, Method: Compositional matrix adjust. Identities = 621/1603 (38%), Positives = 909/1603 (56%), Gaps = 53/1603 (3%) Query: 645 QNSLEAAAAGIQLEGRDSGRYSKAEISVGQVWGAVLGMNPMSVTADFYEIGGDSIIAIEI 704 + SL + ++ R + E + +W LG+N + + + F+E GG S+ A + Sbjct: 2598 KKSLPVPERSVTMDRRYEAPRDQMEEKLVSIWEEALGINKIGINSHFFEAGGHSLKAAAL 2657 Query: 705 VNTLNTIMGLSLQVPVLFEHSNIERLAAYIEGQAGTDKDTRGNSAIPRIAAAEHYEVSSS 764 V+T++ + + L + +FE I+ L + R P +Y +SS+ Sbjct: 2658 VSTIHKELNVKLPLRQIFETPTIKGLRDISVRRRKCFYIDRKTEEKP------YYRLSSA 2711 Query: 765 QKRIYILNQLNARSTSYNIPLFVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSFVNKELV 824 QKR+YIL+Q + +YN+P + +EG D R E++ + +++RHE RTSF ++ E++ Sbjct: 2712 QKRLYILSQTGSH-VAYNMPFAMTLEGDFDIRRFENTLKNMVKRHESFRTSFVMIDGEVM 2770 Query: 825 QAVDDHVHLAVEKYHADDETDLDQITSQFIRPFDLSKAPLIRAGLVEIRKNKHLLMLDVQ 884 Q ++ + V E+ ++I S FIRPF L KAPL+RA +V++ + +HLLM D+ Sbjct: 2771 QQIEKEIDFQVAYSDIGKESAEEKIKS-FIRPFHLEKAPLLRAEVVKLNEREHLLMFDMH 2829 Query: 885 HIIADGSSIPLLQKEIIHLYEHNPLPELNIQFKDFAKWQNDLFKTDYMNKQKKYWLDVFS 944 HII+DG S + +E+ LYE L +IQ+KD+A+W+N +++ + +Q++YWL + Sbjct: 2830 HIISDGVSTDIFIQELGALYEGKSLKPFHIQYKDYAEWENSHARSEELKRQEEYWLKTYK 2889 Query: 945 GELPILNLPVDYPRDSGQGDQGERLTCNAGRELTQRLNEYSSKEKTTLFMTLLAAFNVLL 1004 G++P+L+LP+D+ R + +G+ +T E ++L + + T++M LLA + LL Sbjct: 2890 GDIPVLDLPIDHKRPLTKSSEGDTVTAAIESETFRKLQHMAKENGVTMYMLLLAGYTALL 2949 Query: 1005 FKHTGQEDIIVGSPIAGRKHKELEQMIGMFVNTLALRNRPSAHMVFKEFLAGVKENALQA 1064 K+TGQEDIIVG+P AGR H++++ +IGMFVNTLA+RN P F+++L VKEN LQA Sbjct: 2950 SKYTGQEDIIVGTPAAGRNHEDIQHLIGMFVNTLAIRNHPEGKKTFRDYLQEVKENTLQA 3009 Query: 1065 YEHQDYPFEELVDHLNMDRNLSGTALFNVMFVLQVMDNPAFEVNGMHYAPYPYHNKTAKF 1124 YE+QDYPFEELV+ +N+ R+++ LF+ M V D FE G+ +KF Sbjct: 3010 YENQDYPFEELVEKVNIKRDMARNPLFDTMLVYHNTDVKPFEAEGLRSRLVEIKRGISKF 3069 Query: 1125 DLALQVFPGLDELKFEFTYAAKLFKRSTIESFARRFLRVLEQVVALEHVLIGDIDVLDRE 1184 D+ + D L+ E Y+ LF + +E + + +LEQ + I IDVL + Sbjct: 3070 DITVTASEAADGLRLEVEYSTTLFNKERMERLSEHLISLLEQAADHPDIAINQIDVLTKG 3129 Query: 1185 E----LRDIRRYGQAGLPAAYNTKTIVEMFEAQAARIPDHLAVSGFDRSLTYRELNEQAN 1240 E L D R TI E+FE QA + PDH AV+ D +++YRELNE+AN Sbjct: 3130 ERHRVLYDFNRTDGVFCKEM----TIPELFEKQAEKTPDHPAVAFGDETISYRELNERAN 3185 Query: 1241 QLARVLIRNGACKDRVVGIIAERSTNFAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDS 1300 LA L + G D + GI+ ERS VGIMG+LK+G AYLPI+PAYP ER ++++DS Sbjct: 3186 SLAFTLRQKGVGPDVIAGILTERSIEMIVGIMGILKAGGAYLPIDPAYPQERISYIVKDS 3245 Query: 1301 GACMVLTDTAHRRSLQHGIREICLEEVAGNSGEQGNLEATASADSLAYVIYTSGSTGKPK 1360 VL + +I + G + NL+ LAYVIYTSGSTGKPK Sbjct: 3246 DVS-VLCAAGDVDPGEAYTGDIIRIDQTGQNDHVENLKHDIKPQHLAYVIYTSGSTGKPK 3304 Query: 1361 GVMIEHRSVTNLAEALDEKIYSLHGPNLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPG 1420 GVMIEH SV NL L+E+IY +LNVAL+AP++FDASVKQIF+A L GH L IVP Sbjct: 3305 GVMIEHHSVNNLVHGLNERIYQHLDAHLNVALVAPYIFDASVKQIFAALLFGHTLCIVPR 3364 Query: 1421 DVRQDVIQLAEYYKQNKIDISDGTPAYLRLLA---ETSLCARIGVAHFIIGGEALSIAEV 1477 + D + L EYY +N I++SD TPA+L +LA +T L V I+GG+AL+ + Sbjct: 3365 ETAWDAMSLIEYYSKNNINVSDMTPAHLNMLAYVDKTEL--EFDVKELIVGGDALTPDVI 3422 Query: 1478 KRFYTSFANHKPPYITNVYGPTECCVDATAFTIKPEETGQIQEMPIGAPIKNCSVYILDE 1537 + F N ITNVYGPTECCVDA + I+ + Q +PIG P+ N S+YI+D+ Sbjct: 3423 GGLFHKFPNLSCN-ITNVYGPTECCVDAASHQIESGKVPQTPSIPIGRPLLNTSIYIVDK 3481 Query: 1538 QKRMVPRGVLGELYIGGHGVARGYCNNKALTSSRFVEDIYHPGMYMYKTGDMGKWTEDGL 1597 + R +P G+ GEL I G GVARGY N LT+ +FV+ + PG MYKTGD+ W DG Sbjct: 3482 ELRPLPVGIAGELCIAGEGVARGYVNRPELTAEKFVDHPFEPGKKMYKTGDLAMWLPDGQ 3541 Query: 1598 IHFAGRADHQVKIRGFRIELDEIRHRLLSCDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQ 1657 I F GRADHQVKIRG+RIEL E+ +LL+ + ++ A V+ KDQ YLCAY+ E Sbjct: 3542 IEFLGRADHQVKIRGYRIELGEVEQQLLTHEKIKEAAVIAGKDQNGNSYLCAYIASDKEL 3601 Query: 1658 VLPGLRGYLGEYLPDYMIPRVIMPVDQIPMTANGKADTSQLPDPQEMRD--HSLGYGAPR 1715 +R +L +PDYMIP + +D++P T +GK D S LP+ + GY PR Sbjct: 3602 PAADVRQFLEREMPDYMIPSYFVKLDRLPRTPSGKVDRSALPEADGNVNVMEGTGYDPPR 3661 Query: 1716 NRTEEILCTVWSEVLELRRIGIHDNFFAAGGDSIKAIQAAARMEKYNLRLEVKHLFQYQT 1775 N E L VW E+L IGI +FFAAGGDSIKA+Q +R+ K NL+LE+K LF Sbjct: 3662 NEIERKLVQVWREILGAEDIGISHHFFAAGGDSIKALQIVSRLAKMNLKLEMKALFANPK 3721 Query: 1776 IGEVSKKVQDRAGHAGYGA-VTGEAGLVPIQSWMVEHCRDTLQHRNLSFVLYREAGFGED 1834 I ++S+ + + H + VTGE L+PIQ + ++ L H N SF+L+R+ G+ E+ Sbjct: 3722 IKDLSRFITEETRHRKHNKPVTGETELLPIQKRYFANNKEELDHFNQSFMLFRKDGYDEN 3781 Query: 1835 NIRKVFTEIIRHHDALRMVFREQNRQMLQHNRGLDGELFDFYLIDLADSPSFSEEXXXXX 1894 +R F +I+ HDALRM++ E++ ++Q+NRG LFD + D+ S E+ Sbjct: 3782 IVRTAFNKILEQHDALRMIYEEKDGDIIQYNRGYRENLFDLDVYDVRGFDSQEEKVFELA 3841 Query: 1895 XXXXXSMDLEKGPLVKLALIRAGYGEHLLIVIHQMIIDHLSWRIILEDFNTAYTQLLNHE 1954 + KG LV L + RA G+HLLI IH +++D +SWRI+ EDF T Y Q L E Sbjct: 3842 TGIQKKSSIRKGKLVHLGIFRADEGDHLLIAIHHLVVDGVSWRILFEDFETLYLQALKGE 3901 Query: 1955 DIGLPPKTAPFLQWSNHLHEYADSIELLREQPYWDQ-----VESIKAEPLPTDYKADEA- 2008 + + KT + +++ L +YA S LL+E+ YW + V I AE L D A Sbjct: 3902 PLDIGYKTDSYQEFARQLKKYAQSRRLLKEREYWQKALEADVPFIPAEKLERDTFEHSAT 3961 Query: 2009 ---RVRDNLT---LYQAFDCTETEQVMSSIRSNPHFTTESIMLTALALTIRAWTGNAAVV 2062 R+ ++T L AF TE I+LTAL +R TG + Sbjct: 3962 LSIRIGPDVTAKLLRNAFKAYNTE-------------INDILLTALIAAVRDITGENKLK 4008 Query: 2063 VNLGNHGRDMDSKDIDTYRTVGRFSILYPVALQLPESRNIDLCLEYVKEYLSGIPKQGGG 2122 V + HGR+ +D RT+G F+ +YPV + L E + I ++ VKE L IP +G G Sbjct: 4009 VMMEGHGREDILDGVDITRTIGWFTTVYPVFIDLGEEKEISQNIKMVKEALRKIPNKGIG 4068 Query: 2123 YGVLKYLSSHQEGIRFRLNPELSFNYMGQFDAEFNTSTFRISPLSGGEDRSGEEIWSYKL 2182 YGVLKY++ +E + + LSFNY G+ + + N F SP S GE G+ + + Sbjct: 4069 YGVLKYMT--EELQKIQTQAPLSFNYFGEMNNDMNRKVFSQSPFSPGESIGGKIVRHCAI 4126 Query: 2183 KFISFIRMNQLNIGIEYNQQQYARETVNALLQQYMEYLKKAAE 2225 + + +L I +NQ QY T+ L Q + E L+K + Sbjct: 4127 EMNAISLNGELTIYTTFNQDQYQTSTIEQLNQSFKENLEKIVD 4169 Score = 785 bits (2028), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/1457 (33%), Positives = 777/1457 (53%), Gaps = 77/1457 (5%) Query: 658 EGRDSGRY---SKAEISVGQVWGAVLGMNPMSVTADFYEIGGDSIIAIEIVNTLNTIMGL 714 EG+ GR ++ + + ++W + G++ +++ +YEIGGDS+ AI I+ +N M + Sbjct: 1572 EGQRGGRMLPENETQAMLLEIWKDIFGLDSINLDVSYYEIGGDSLKAISIITEINKRMNV 1631 Query: 715 SLQVPVLFEHSNIERLAAYIEGQAGTDKDTRGNSAIPRIAAAEHYEVSSSQKRIYILNQL 774 + + +F++ I L Y++ + +D + I + E+Y S +Q+R+Y+L+ L Sbjct: 1632 EMPISEIFKNDTIIALDHYLKNREESDME----HPIQKAREKEYYPTSPAQQRMYMLSML 1687 Query: 775 NARSTSYNIPLFVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSFVNKELVQAVDDHVHLA 834 +Y+IP+ +++EG ++ +LE++ + +QRHE+LRT F N EL+Q + ++V Sbjct: 1688 ENERGAYHIPMALLVEGRINAMQLENALKTFLQRHEILRTGFEIQNNELIQKIYENVDFR 1747 Query: 835 VEKYHAD----DETDLDQITSQF----IRPFDLSKAPLIRAGLVEIRKNKHLLMLDVQHI 886 +E D D+ L +ITS++ I+PFDLS+ PL+RA L++I +H+L+++ HI Sbjct: 1748 LEYECLDASITDQHALMEITSRYCKESIKPFDLSRPPLMRAKLIKIDDIRHILVINFHHI 1807 Query: 887 IADGSSIPLLQKEIIHLYEHNPLPELNIQFKDFAKWQNDLFKTDYMNKQKKYWLDVFSGE 946 I+DG S +L EI+ LY + PLPE+N+Q+KD+ +W + ++ M KQ+ YWLDV+ Sbjct: 1808 ISDGVSQGILMNEILELYSNVPLPEVNVQYKDYVEWNHTFNQSAAMKKQEAYWLDVYRDI 1867 Query: 947 LPILNLPVDYPRDSGQGDQGERLTCNAGRELTQRLNEYSSKEKTTLFMTLLAAFNVLLFK 1006 L+ P DY R +G + REL+ + + + TTL+ +L+A+ VLL K Sbjct: 1868 PSKLDFPYDYKRHHIDTFEGSSVFLEMERELSDHIRKLAKHNGTTLYTVMLSAYYVLLNK 1927 Query: 1007 HTGQEDIIVGSPIAGRKHKELEQMIGMFVNTLALRNRPSAHMVFKEFLAGVKENALQAYE 1066 +T Q DI+VG+ AGR H +L+ + G+FVNTLALRN FKEFL KE + A++ Sbjct: 1928 YTNQTDIVVGTAAAGRLHPDLQDVFGVFVNTLALRNEVDTSYSFKEFLQQTKERTIAAFD 1987 Query: 1067 HQDYPFEELVDHLNMDRNLSGTALFNVMFVLQVMDNPAFEVNGMHYAPYPYHNKTAKFDL 1126 + +YPF++L+ LN R + LF+ MFVL+ + + +P + AKFD+ Sbjct: 1988 NSEYPFDDLIRKLNGVRESNRNPLFDTMFVLEDARMFTKQKGDVKLSPIIFELDNAKFDM 2047 Query: 1127 ALQVFPGLDELKFEFTYAAKLFKRSTIESFARRFLRVLEQVVALEHVLIGDIDVLDREEL 1186 V ++ Y+ LFK TI+ A + R+LE+V V + ID++ R+E Sbjct: 2048 IFNVLDFEQKIVLNIEYSTSLFKDETIQKIAEDYFRILEEVSENLDVALHQIDMISRQEK 2107 Query: 1187 RDIRRYGQAGLPAAYNTKTIVEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVL 1246 R + A K I ++FE QA RIPDH AV D+ LTYR+LNE+ANQ+AR+L Sbjct: 2108 RTLLESFNHTKTAYPKGKAIHQLFEEQAKRIPDHTAVVFEDQKLTYRQLNEKANQVARLL 2167 Query: 1247 IRNGACKDRVVGIIAERSTNFAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVL 1306 G D +VGI+ ERS++ I+GVLK+G AYLPI+P YPPER R+M DS +++ Sbjct: 2168 REKGVKPDTLVGIMMERSSDMIAAILGVLKAGGAYLPIDPEYPPERMRYMAFDSEVKVII 2227 Query: 1307 TDTAHRRSLQ-HGIREICL--EEVAGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVM 1363 +D L I I + E +AG ++ +++ + LAYVIYTSGSTGKPKGVM Sbjct: 2228 SDVPLAEELTAESIELIHMDDERIAGQ--DRSDIDNVNQSGDLAYVIYTSGSTGKPKGVM 2285 Query: 1364 IEHRSVTNLAEALDEKIYSLHGPNLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVR 1423 IEH+S+ NL + + + + G N N ++ A FDA V ++F G ++++ + R Sbjct: 2286 IEHQSLINLC-SWHQSCFEV-GQNDNSSIYASISFDAFVWELFPYITAGATVHVLNQETR 2343 Query: 1424 QDVIQLAEYYKQNKIDISD-GTPAYLRLLAETSLCARIGVAHFIIGGEALSIAEVKRFYT 1482 DV +L Y+ + I IS TP + A + R + GG+ L++ + K + Sbjct: 2344 LDVEKLNRYFHDHHITISFLPTPVCEQFTALDNHSLRT----LLTGGDKLNVFKEKSYQ- 2398 Query: 1483 SFANHKPPYITNVYGPTECCVDATAFTIKPEETGQIQEMPIGAPIKNCSVYILDEQKRMV 1542 I N YGPTE V AT+F I Q +PIG PI N VYIL++ ++ Sbjct: 2399 ---------IVNNYGPTENTVVATSFPIDKSH----QNIPIGKPIDNVKVYILNKDLQLC 2445 Query: 1543 PRGVLGELYIGGHGVARGYCNNKALTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAG 1602 P G GEL I G G+ARGY N LT +F+ + + PG MY+TGD+ K DG I F G Sbjct: 2446 PLGASGELCIAGEGLARGYVNRPELTREKFIGNPFVPGERMYRTGDLAKMLPDGNIQFLG 2505 Query: 1603 RADHQVKIRGFRIELDEIRHRLLSCDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGL 1662 R D QVKIRG+RIE EI +RLL + ++ A V+ ++D +PYLCAYV + E + Sbjct: 2506 RVDQQVKIRGYRIEPGEIENRLLKYEKIEEAAVIAREDGDHDPYLCAYVTVKKEVEPEKI 2565 Query: 1663 RGYLGEYLPDYMIPRVIMPVDQIPMTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEIL 1722 R +L + LPDYMIP+ + +D +P+T NGK D LP P+ Y APR++ EE L Sbjct: 2566 RAFLKKSLPDYMIPQYFVQLDGLPLTVNGKVDKKSLPVPERSVTMDRRYEAPRDQMEEKL 2625 Query: 1723 CTVWSEVLELRRIGIHDNFFAAGGDSIKAIQAAARMEK-YNLRLEVKHLFQYQTIG---E 1778 ++W E L + +IGI+ +FF AGG S+KA + + K N++L ++ +F+ TI + Sbjct: 2626 VSIWEEALGINKIGINSHFFEAGGHSLKAAALVSTIHKELNVKLPLRQIFETPTIKGLRD 2685 Query: 1779 VSKK------VQDRAGHAGYGAVTGEAGLVPIQSWMVEHCRDTLQHRNLSFVLYREAGFG 1832 +S + + + Y ++ + I S H N+ F + E F Sbjct: 2686 ISVRRRKCFYIDRKTEEKPYYRLSSAQKRLYILSQTGSHVA-----YNMPFAMTLEGDFD 2740 Query: 1833 EDNIRKVFTEIIRHHDALRMVFREQNRQMLQHNRGLDGELFDFYLIDLADSPSFSEEXXX 1892 +++ H++ R F + +++Q ++ E+ DF +A S E Sbjct: 2741 IRRFENTLKNMVKRHESFRTSFVMIDGEVMQQ---IEKEI-DF---QVAYSDIGKESAEE 2793 Query: 1893 XXXXXXXSMDLEKGPLVKLALIRAGYGEHLLIV-IHQMIIDHLSWRIILEDFNTAYTQLL 1951 LEK PL++ +++ EHLL+ +H +I D +S I +++ Y Sbjct: 2794 KIKSFIRPFHLEKAPLLRAEVVKLNEREHLLMFDMHHIISDGVSTDIFIQELGALY---- 2849 Query: 1952 NHEDIGLPPKTAPFLQWSNHLHEYADSIELLREQPYWDQVES--IKAEPLPTDYKADEAR 2009 E L P + ++ + +A S EL R++ YW + I LP D+K + Sbjct: 2850 --EGKSLKPFHIQYKDYAEWENSHARSEELKRQEEYWLKTYKGDIPVLDLPIDHKRPLTK 2907 Query: 2010 VRDNLTLYQAFDCTETEQVMSSIRSNPHFTTESIMLTALALTIRAWTGNAAVVVNLGNHG 2069 + T+ A + +ET + + + T ++L + +TG ++V G Sbjct: 2908 SSEGDTVTAAIE-SETFRKLQHMAKENGVTMYMLLLAGYTALLSKYTGQEDIIVGTPAAG 2966 Query: 2070 RDMDSKDIDTYRTVGRF 2086 R+ + D +G F Sbjct: 2967 RNHE----DIQHLIGMF 2979 Score = 499 bits (1286), Expect = e-139, Method: Compositional matrix adjust. Identities = 323/1058 (30%), Positives = 535/1058 (50%), Gaps = 63/1058 (5%) Query: 759 YEVSSSQKRIYILNQLNARSTSYNIPLFVMMEGPLDEGRLEHSFEALIQRHEVLRTSFS- 817 Y +++ QK + N ++ S +Y + + ++G + LE SF +++RHE+LR SF Sbjct: 4210 YPLANMQKGMLFHNAMDQTSGAYFQQIVIKLKGRVHPDILEESFHEIVKRHEILRASFEY 4269 Query: 818 -----------------FVNKELVQAVDDHVHLAVEKYHADDETDLDQITSQFIRPFDLS 860 F + +L H +E Y +D+ + FDLS Sbjct: 4270 EITAEPRQIIARDRKTPFTSIDLTGENRTRQHRFIETYLKEDQE----------KGFDLS 4319 Query: 861 KAPLIRAGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLY------EHNPLPELNI 914 L+R L+++ + L+ HI+ DG + ++ E+ LY E L E Sbjct: 4320 SEALMRVCLIKMSDESYRLIWSHHHILLDGWCLGIVLSELFSLYGKIMKGESRRLKEPK- 4378 Query: 915 QFKDFAKWQNDLFKTDYMNKQKKYWLDVFSGELPILNLPVDYPRDSGQGDQGERLTCNAG 974 + D+ KW L K D + YW D G LP + + G+ + Sbjct: 4379 PYGDYIKW---LEKQD-QEEAVAYWKDYLKGYESRSELPAFNRGATSEEYCGKEKVISFS 4434 Query: 975 RELTQRLNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKH--KELEQMIG 1032 +ELT ++ + + T+ L + ++L K+ ++++ G+ ++GR+ +E+M+G Sbjct: 4435 KELTTKITRIAKQHHVTINTVLQGIWGMILAKYKNTDEVVFGTVVSGREAPVDGIEEMVG 4494 Query: 1033 MFVNTLALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNLSG--TAL 1090 +F++T+ R FKE L + ++++ + E+ M R L A Sbjct: 4495 LFIHTIPTRISFEGARSFKEVLKKTQAESIESNRYSYMNLSEIQVLSEMKRELITHVMAF 4554 Query: 1091 FNVMFVLQVMDNPA----FEVNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAAK 1146 N F ++ + + FE+ G+H + ++ L ++LK + T+ Sbjct: 4555 QNYAFDEELFRSQSGETGFELEGVH------GKERTNYNFNLTGVLEDEQLKLKLTFNEN 4608 Query: 1147 LFKRSTIESFARRFLRVLEQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAYNTKTI 1206 ++ + IE+ + + V EQV E + DI+++ +EE I K + Sbjct: 4609 VYDNTIIETLEKHIITVAEQVAEDETQTLRDINLVSKEEQHRILHTFNDTKTGYPKDKPL 4668 Query: 1207 VEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERSTN 1266 E+FE QA + PDH A+ + +TYRELNE+ANQ AR+L G + + IIA+RS Sbjct: 4669 HELFEEQAMKTPDHTALVFGAQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADRSFE 4728 Query: 1267 FAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLEE 1326 +GI+G+LK+G YLPI+P P +R +ML++SGA +++T + + ++C +E Sbjct: 4729 MIIGIIGILKAGGTYLPIDPETPRDRIDYMLKNSGAALLVTTDSLLKPFDIKTVDLCSDE 4788 Query: 1327 VAGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKIYSLHGP 1386 + S E NL + AY++YTSGSTG PKGV+I H S + + + + G Sbjct: 4789 LHLLSEE--NLPRVNRSSDTAYIVYTSGSTGTPKGVVIPHYSAARVVK--NTNYIDITGN 4844 Query: 1387 NLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPA 1446 ++ + L+ + FD SV IF A L G L ++ + + +LAE K+ ++ + T A Sbjct: 4845 DV-ILQLSNYSFDGSVFDIFGALLNGASLVLIEKETVLNTHELAEVIKKEQVSVMFITTA 4903 Query: 1447 YLRLLAETSLCARIGVAHFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPTECCVDAT 1506 LA+ ++ + + GGE SI V++ K + +VYGPTE V AT Sbjct: 4904 LFNTLADINIGCLAKLRKILFGGERASIPHVRKVLDHVGRDK---LIHVYGPTESTVYAT 4960 Query: 1507 AFTIKPEETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYCNNKA 1566 + I E + + +PIG+P+ N SV I+DE +++P GV GEL I G G+++GY N + Sbjct: 4961 YYFIN-EIDDEAETIPIGSPLANTSVLIMDEAGKLLPIGVPGELCIAGDGLSKGYLNREE 5019 Query: 1567 LTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHRLLS 1626 LT+ +F+ + PG +YKTGD+ KW DG I F GR DHQVKIRGFRIEL EI RL Sbjct: 5020 LTAEKFIPHPFIPGERLYKTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEM 5079 Query: 1627 CDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMPVDQIP 1686 + + +V V++D+ PY+CAY+ E L L+G+LGE LPDYMIP + +D++P Sbjct: 5080 HEDINETIVTVREDEESRPYICAYITANREISLDELKGFLGEKLPDYMIPAYFVKMDKLP 5139 Query: 1687 MTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFAAGG 1746 +T NGK D LP+P Y APRN E+ + ++ +VL R+GI +FF GG Sbjct: 5140 LTKNGKVDRKALPEPDRSAGTEAEYEAPRNYVEQRIISILEDVLGTERMGISCHFFDKGG 5199 Query: 1747 DSIKAIQAAARMEK-YNLRLEVKHLFQYQTIGEVSKKV 1783 +S+KA+QA + K + + + + F++ T +++ V Sbjct: 5200 NSLKAMQAVHSINKTFGIDMRISTFFKHPTAKSLARFV 5237 Score = 433 bits (1114), Expect = e-119, Method: Compositional matrix adjust. Identities = 387/1549 (24%), Positives = 695/1549 (44%), Gaps = 143/1549 (9%) Query: 587 ICSLYEKGGEVDWESL--YEGEKRGKISIPVY-------PFLKERHWVNAPRRKTAEPDE 637 IC+ E+ + L + GEK + IP Y P K N + A P+ Sbjct: 473 ICAYITANREISLDELKGFLGEKLPEYMIPAYFVKLDKLPLTK-----NGKVDRKALPEP 527 Query: 638 EEQEGLWQNSLEAAAAGIQLEGRDSGRYSKAEISVGQVWGAVLGMNPMSVTADFYEIGGD 697 + G +N EA ++ E + VW VL + + F ++GG Sbjct: 528 DRTAGA-ENEYEAPR-------------NETEEKLAAVWQDVLHVEKAGIHDHFAQMGGH 573 Query: 698 SIIAIEIVNTLNTIMGLSLQVPVLFEHSNIERLAAYIEGQAGTDKDTRGNSAIPRIAAAE 757 S+ A+E++ + M + + + LF+ + I+ L+A+IE DK G++ + R A E Sbjct: 574 SLHAMELIAKIKEKMNVEIPLHQLFKLATIKELSAFIEANHQEDK---GDTLVTRAADPE 630 Query: 758 H----YEVSSSQKRIYILNQLNARSTSYNI-----PLFVMMEGPLDEGRLEHSFEALIQR 808 + + ++ Q L L R ++ I L V E +D R + + + LI R Sbjct: 631 NIHEIFPLTGIQ-----LAYLVGRDETFEIGGVATNLTVEFEADVDLNRFQLTLQKLIDR 685 Query: 809 HEVLRT-SFSFVNKELVQAVDDH-VHLAVEKYHADDETDL------DQITSQFIRPFDLS 860 H +LRT F +++++A + + + ++E ++ +++TS+ I P S Sbjct: 686 HPILRTIVFENGTQKILEATQRYTIETQDLRGFTEEEINVRILEQREKMTSKIIDP---S 742 Query: 861 KAPLIRAGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYEHNP---LPELNIQFK 917 PL + K L+V +I D SS+ L +E LYE NP LP L F+ Sbjct: 743 VWPLFELKTFMLPGEKKYFFLNVDPLICDDSSMKRLIREFKQLYE-NPGLQLPSLEYSFR 801 Query: 918 DFAKWQNDLFKTDYMNKQKKYWLDVF-----SGELPILNLPVDYPRDSGQGDQGERLTCN 972 D+ + +T K ++YWLD + ELP+ + P + S + + + Sbjct: 802 DYVLASINFKQTSRYQKDQQYWLDKLDHFPSAPELPLKSDPAHVAKPSFK-----KFSTF 856 Query: 973 AGRELTQRLNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRK--HKELEQM 1030 L + + T L AA+ +L + Q + + R H +++ M Sbjct: 857 LDGHTWNELKKKARHHHLTPTSVLCAAYAYILAYWSRQNHFAINLTVFNRIPFHPDVKNM 916 Query: 1031 IGMFVNTLALRNRPSAHMV-FKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNLSGTA 1089 IG F + + L +M F F V++ L+A EH+ Y +++ ++ ++ A Sbjct: 917 IGDFTSLMLLDIHAEENMSSFWRFALNVQDTLLEALEHRHYDGVDVIRNIAKKNGMNKKA 976 Query: 1090 LFNVMFVLQVMDNP------AFEVNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTY 1143 + ++F + +NP + + +H+ + +T++ + QV+ L + Y Sbjct: 977 VMPIVFTSVLSENPDDSFDSLVDFDNIHF----FSTRTSQVYIDNQVYEINGGLYITWDY 1032 Query: 1144 AAKLFKRSTIESFARRFLRVLEQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAYNT 1203 ++F+ IES +++ V+++ V+ E V ++ R+ + Q+ ++ Sbjct: 1033 VEQIFEHEVIESMFDQYIAVIQKAVSGEDVSTIQMNEKSRQMISAYNDTDQS-----FDA 1087 Query: 1204 KTIVEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAER 1263 K + E+F Q PD +A+ D +TY+EL+E++NQ+AR LI G K +G+I +R Sbjct: 1088 KPLHELFTGQVKHGPDRMALKHHDEVMTYQELDEKSNQVARFLIGKGVEKGDYIGVIGKR 1147 Query: 1264 STNFAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREIC 1323 S V ++ VLK+GAAY+P++P YP ERK ++ S ++ + + Sbjct: 1148 SLGTIVNLLAVLKTGAAYIPLDPDYPEERKAYIQSKSNCKFFISHDVYDK---------- 1197 Query: 1324 LEEVAGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKIYSL 1383 E + S + ++ D +AYVI+TSGSTGKPKGV I H N ++EK Sbjct: 1198 -EHIERFS--KAPVDRKVDLDDMAYVIFTSGSTGKPKGVQITHVPQRNTILDINEKFNVT 1254 Query: 1384 HGPNLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDG 1443 N + ++ FD SV +F A G L I+ D ++DV L E ++ +I I + Sbjct: 1255 EQDN--IMGISSLCFDLSVYDVFGALSSGASLVII--DDQRDVFSLKETAEKERITIWNS 1310 Query: 1444 TPAYLRLLAETSLCARIG--VAHFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPTEC 1501 PA + + A+ + + ++ G+ + + +F N + + ++ G TE Sbjct: 1311 VPAIMGMTADVYPDNELNHHLRLILLSGDWIPLQLPATIKKTFKNAE---VISLGGATEG 1367 Query: 1502 CVDATAFTIKPEETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGY 1561 + + + I+ E + +P G P+ N +Y+L++ K++ P GV GELYIGG GVA GY Sbjct: 1368 SIWSIYYPIQKVEEDW-KSIPYGKPLANQKIYVLNQNKQLCPVGVEGELYIGGAGVASGY 1426 Query: 1562 CNNKALTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIR 1621 +++ T F++ + Y+YKTGD G EDG + F GR D QVKIRG+R+E+ EI Sbjct: 1427 IHDQEKTEHSFIQ--HQELGYIYKTGDYGVLKEDGYVEFLGRKDSQVKIRGYRVEMGEIE 1484 Query: 1622 HRLLSCDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMP 1681 + L+S + A V+ L A+VV + ++ +L + LPDYMIP + Sbjct: 1485 NTLVSHQEITKASVIDYTSPDGIKNLYAFVVAENAISQLDVKEFLQKTLPDYMIPAKFVQ 1544 Query: 1682 VDQIPMTANGKADTSQLPDPQEMRDHSLGYGA----PRNRTEEILCTVWSEVLELRRIGI 1737 +++IP+T NGK D L D E G P N T+ +L +W ++ L I + Sbjct: 1545 IEEIPLTVNGKVDKRTLHDLAEQHTADEGQRGGRMLPENETQAMLLEIWKDIFGLDSINL 1604 Query: 1738 HDNFFAAGGDSIKAIQAAARMEK-YNLRLEVKHLFQYQTIGEVSKKVQDR----AGHAGY 1792 +++ GGDS+KAI + K N+ + + +F+ TI + +++R H Sbjct: 1605 DVSYYEIGGDSLKAISIITEINKRMNVEMPISEIFKNDTIIALDHYLKNREESDMEHPIQ 1664 Query: 1793 GAVTGEA-GLVPIQS--WMVEHCRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDA 1849 A E P Q +M+ + ++ L E + ++ H+ Sbjct: 1665 KAREKEYYPTSPAQQRMYMLSMLENERGAYHIPMALLVEGRINAMQLENALKTFLQRHEI 1724 Query: 1850 LRMVFREQNRQMLQH-----NRGLDGELFDFYLIDLADSPSFSEEXXXXXXXXXXSMDLE 1904 LR F QN +++Q + L+ E D + D + E DL Sbjct: 1725 LRTGFEIQNNELIQKIYENVDFRLEYECLD---ASITDQHALMEITSRYCKESIKPFDLS 1781 Query: 1905 KGPLVKLALIRAGYGEHLLIV-IHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLPPKTA 1963 + PL++ LI+ H+L++ H +I D +S I++ + Y+ ++ LP Sbjct: 1782 RPPLMRAKLIKIDDIRHILVINFHHIISDGVSQGILMNEILELYS------NVPLPEVNV 1835 Query: 1964 PFLQWSNHLHEYADSIELLREQPYW-DQVESIKAE-PLPTDYKADEARVRDNLTLYQAFD 2021 + + H + S + +++ YW D I ++ P DYK + +++ + Sbjct: 1836 QYKDYVEWNHTFNQSAAMKKQEAYWLDVYRDIPSKLDFPYDYKRHHIDTFEGSSVFLEME 1895 Query: 2022 CTETEQVMSSIRSNPHFTTESIMLTALALTIRAWTGNAAVVVNLGNHGR 2070 ++ + + N T ++ML+A + + +T +VV GR Sbjct: 1896 RELSDHIRKLAKHNGT-TLYTVMLSAYYVLLNKYTNQTDIVVGTAAAGR 1943 Score = 431 bits (1108), Expect = e-118, Method: Compositional matrix adjust. Identities = 290/894 (32%), Positives = 448/894 (50%), Gaps = 51/894 (5%) Query: 1204 KTIVEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAER 1263 KT+ E+FE QA + PDH A+ + +TYRELNE+ANQ AR+L G + + IIA+R Sbjct: 37 KTLHELFEEQAMKTPDHTALVFGAQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADR 96 Query: 1264 STNFAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREIC 1323 S +GI+G+LK+G AYLPI+P P +R FML D+ A ++LT + + Sbjct: 97 SFEMIIGIIGILKAGGAYLPIDPETPKDRIAFMLSDTKAAVLLTQGKAADGIDCEADIVQ 156 Query: 1324 LEEVAGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKIYSL 1383 L+ A + + L + + AY+IYTSGSTG PKGV+ H SV + + + + Sbjct: 157 LDREASDGFSKEPLSSVNDSGDTAYIIYTSGSTGTPKGVITPHYSVIRVVQNTN----YI 212 Query: 1384 HGPNLNVAL-LAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISD 1442 NV L L+ + FD SV IF A L G L ++ + ++ +L + K+ + Sbjct: 213 DITEDNVILQLSNYSFDGSVFDIFGALLNGASLVMIEKEALLNINRLGSAINEEKVSVMF 272 Query: 1443 GTPAYLRLLAETSLCARIGVAHFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPTECC 1502 T A ++A+ + + + GGE SI V++ K + +VYGPTE Sbjct: 273 ITTALFNMIADIHVDCLSNLRKILFGGERASIPHVRKVLNHVGRDK---LIHVYGPTEST 329 Query: 1503 VDATAFTIKPEETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYC 1562 V AT + I E + + +PIG+P+ N SV I+DE ++VP GV GEL I G G+++GY Sbjct: 330 VYATYYFIN-EIDDEAETIPIGSPLANTSVLIMDEAGKLVPIGVPGELCIAGDGLSKGYL 388 Query: 1563 NNKALTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRH 1622 N + LT+ +F+ + PG +YKTGD+ KW DG I F GR DHQVKIRGFRIEL EI Sbjct: 389 NREELTAEKFIPHPFIPGERLYKTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIES 448 Query: 1623 RLLSCDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMPV 1682 RL + + +V V++D+ PY+CAY+ E L L+G+LGE LP+YMIP + + Sbjct: 449 RLEMHEDINETIVTVREDEESRPYICAYITANREISLDELKGFLGEKLPEYMIPAYFVKL 508 Query: 1683 DQIPMTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFF 1742 D++P+T NGK D LP+P Y APRN TEE L VW +VL + + GIHD+F Sbjct: 509 DKLPLTKNGKVDRKALPEPDRTAGAENEYEAPRNETEEKLAAVWQDVLHVEKAGIHDHFA 568 Query: 1743 AAGGDSIKAIQAAARM-EKYNLRLEVKHLFQYQTIGEVSKKVQDRAGH---AGYGAVTGE 1798 GG S+ A++ A++ EK N+ + + LF+ TI E+S ++ A H G VT Sbjct: 569 QMGGHSLHAMELIAKIKEKMNVEIPLHQLFKLATIKELSAFIE--ANHQEDKGDTLVTRA 626 Query: 1799 AG---------LVPIQSWMVEHCRDTLQHRNLS--FVLYREAGFGEDNIRKVFTEIIRHH 1847 A L IQ + +T + ++ + EA + + ++I H Sbjct: 627 ADPENIHEIFPLTGIQLAYLVGRDETFEIGGVATNLTVEFEADVDLNRFQLTLQKLIDRH 686 Query: 1848 DALR-MVFREQNRQMLQHNRGLDGELFDFYLIDLADSPSFSEEX------XXXXXXXXXS 1900 LR +VF +++L+ + Y I+ D F+EE Sbjct: 687 PILRTIVFENGTQKILEATQR--------YTIETQDLRGFTEEEINVRILEQREKMTSKI 738 Query: 1901 MDLEKGPLVKL-ALIRAGYGEHLLIVIHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLP 1959 +D PL +L + G ++ + + +I D S + ++ +F QL + + LP Sbjct: 739 IDPSVWPLFELKTFMLPGEKKYFFLNVDPLICDDSSMKRLIREFK----QLYENPGLQLP 794 Query: 1960 PKTAPFLQWSNHLHEYADSIELLREQPYW-DQVESIKAEP-LPTDYKADEARV-RDNLTL 2016 F + + + ++Q YW D+++ + P LP K+D A V + + Sbjct: 795 SLEYSFRDYVLASINFKQTSRYQKDQQYWLDKLDHFPSAPELP--LKSDPAHVAKPSFKK 852 Query: 2017 YQAFDCTETEQVMSSIRSNPHFTTESIMLTALALTIRAWTGNAAVVVNLGNHGR 2070 + F T + + H T S++ A A + W+ +NL R Sbjct: 853 FSTFLDGHTWNELKKKARHHHLTPTSVLCAAYAYILAYWSRQNHFAINLTVFNR 906 >sp|O30408|TYCB_BREPA Tyrocidine synthetase II [Includes: ATP-dependent proline adenylase (ProA) (Proline activase); ATP-dependent phenylalanine adenylase (PheA) (Phenylalanine activase); ATP-dependent D-phenylalanine adenylase (D-PheA) (D-phenylalanine activase); Phenylalanine racemase [ATP-hydrolyzing] ] pir||T31075 tyrocidine synthetase 2 - Brevibacillus brevis gb|AAC45929.1| tyrocidine synthetase 2 [Brevibacillus brevis] Length = 3587 Score = 1092 bits (2825), Expect = 0.0, Method: Compositional matrix adjust. Identities = 596/1572 (37%), Positives = 900/1572 (57%), Gaps = 48/1572 (3%) Query: 666 SKAEISVGQVWGAVLGMNPMSVTADFYEIGGDSIIAIEIVNTLNTIMGLSLQVPVLFEHS 725 ++ E + +W LG++ + V F+E+GG S+ A+ +V ++ + L + F Sbjct: 2010 TEVEAKLVAIWENALGISGVGVLDHFFELGGHSLKAMTVVAQVHREFQIDLLLKQFFAAP 2069 Query: 726 NIERLAAYIEGQAGTDKDTRGNSAIPRIAAAEHYEVSSSQKRIYILNQLNARSTSYNIPL 785 I LA IE + +AI +Y VSS+Q+R+Y+L+QL SYN P Sbjct: 2070 TIRDLARLIE-----HSEQAAGAAIQPAEPQAYYPVSSAQQRMYLLHQLEGAGISYNTPG 2124 Query: 786 FVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSFVNKELVQAVDDHVHLAVEKYHADDETD 845 +M+EG LD +L ++ +AL+ RH++LRTSF V ELVQ + D V + +E Y +E Sbjct: 2125 IIMLEGKLDREQLANALQALVDRHDILRTSFEMVGDELVQKIHDRVAVNME-YVTAEEQQ 2183 Query: 846 LDQITSQFIRPFDLSKAPLIRAGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYE 905 +D + F+RPFDLS PL+R LV++ +HLL+ D+ HI AD +SI +L E+ LY+ Sbjct: 2184 IDDLFHAFVRPFDLSVPPLLRMSLVKLADERHLLLYDMHHIAADAASITILFDELAELYQ 2243 Query: 906 HNPLPELNIQFKDFAKWQNDLFKTDYMNKQKKYWLDVFSGELPILNLPVDYPRDSGQGDQ 965 LPE+ IQ+KDFA WQ L ++D +Q+ YWL F+G + +++P D+PR + + Sbjct: 2244 GRELPEMRIQYKDFAVWQKALHESDAFKQQEAYWLSTFAGNITAVDVPTDFPRPAVKSFA 2303 Query: 966 GERLTCNAGRELTQRLNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHK 1025 G ++T + +EL L+E ++ TTLFM LLAA+NVLL K+ GQ+DIIVG+PI+GR Sbjct: 2304 GGQVTLSMDQELLSALHELAAHTNTTLFMVLLAAYNVLLAKYAGQDDIIVGTPISGRSRA 2363 Query: 1026 ELEQMIGMFVNTLALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNL 1085 EL ++GMFV+TLA+RN+P+A FK+FL VK+NAL A++HQDYPFE LV+ L + R+ Sbjct: 2364 ELAPVVGMFVHTLAIRNKPTAEKTFKQFLQEVKQNALDAFDHQDYPFESLVEKLGIPRDP 2423 Query: 1086 SGTALFNVMFVLQVMDNPAFEVNGMHYAPYPYHNK--TAKFDLALQVFPGLDELKFEFTY 1143 LF+ MF+LQ + A ++ + Y PY + AKFDL+ + +L Y Sbjct: 2424 GRNPLFDTMFILQNDELHAKTLDQLVYRPYESDSALDVAKFDLSFHLTERETDLFLRLEY 2483 Query: 1144 AAKLFKRSTIESFARRFLRVLEQVVALEHVLIGDIDVLDREE-------LRDIRRYGQAG 1196 KLFK+ T+E A FL++L V A + +I++L E D R +A Sbjct: 2484 CTKLFKQQTVERMAHHFLQILRAVTANPENELQEIEMLTAAEKQMLLVAFNDTHREYRAD 2543 Query: 1197 LPAAYNTKTIVEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRV 1256 +TI ++FE A ++P+H A+ ++ +++RELNE+ANQLA VL G ++ Sbjct: 2544 -------QTIQQLFEELAEKMPEHTALVFEEKRMSFRELNERANQLAAVLREKGVGPAQI 2596 Query: 1257 VGIIAERSTNFAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDT--AHRRS 1314 V ++ ERS + + LK+G A+LP++P YP ER R+MLEDS A +V+T H+ S Sbjct: 2597 VALLVERSAEMVIATLATLKAGGAFLPVDPDYPEERIRYMLEDSQAKLVVTHAHLLHKVS 2656 Query: 1315 LQHGIREICLEEVAGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAE 1374 Q + ++ ++ + + NL + LAY+IYTSG+TGKPKGVM+EH+ V NL Sbjct: 2657 SQSEVVDV--DDPGSYATQTDNLPCANTPSDLAYIIYTSGTTGKPKGVMLEHKGVANL-- 2712 Query: 1375 ALDEKIYSLH---GPNLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAE 1431 + +++ H P A FDASV +F L G L ++ DV D + AE Sbjct: 2713 ---QAVFAHHLGVTPQDRAGHFASISFDASVWDMFGPLLSGATLYVLSRDVINDFQRFAE 2769 Query: 1432 YYKQNKIDISDGTPAYLRLLAETSLCARIGVAHFIIGGEALSIAEVKRFYTSFANHKPPY 1491 Y + N I P Y L + + + I G A S+A V ++ K Y Sbjct: 2770 YVRDNAITFLTLPPTYAIYLEPEQVPS---LRTLITAGSASSVALVDKW-----KEKVTY 2821 Query: 1492 ITNVYGPTECCVDATAFTIKPEETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELY 1551 + N YGPTE V AT + KP+E ++ + IG PI+N +YI+D+Q ++ G +GEL Sbjct: 2822 V-NGYGPTESTVCATLWKAKPDEP--VETITIGKPIQNTKLYIVDDQLQLKAPGQMGELC 2878 Query: 1552 IGGHGVARGYCNNKALTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIR 1611 I G +ARGY N LT+ +FV++ + PG MY+TGD+ +W DG I + GR DHQVKIR Sbjct: 2879 ISGLSLARGYWNRPELTAEKFVDNPFVPGTKMYRTGDLARWLPDGTIEYLGRIDHQVKIR 2938 Query: 1612 GFRIELDEIRHRLLSCDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLP 1671 G R+EL E+ LL D V+ A + +D R + YLCAY V E LR Y+ LP Sbjct: 2939 GHRVELGEVESVLLRYDTVKEAAAITHEDDRGQAYLCAYYVAEGEATPAQLRAYMENELP 2998 Query: 1672 DYMIPRVIMPVDQIPMTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLE 1731 +YM+P + ++++P+T N K D LP P + + + Y AP+ E++L +W++VL Sbjct: 2999 NYMVPAFFIQLEKMPLTPNDKIDRKALPKPNQEENRTEQYAAPQTELEQLLAGIWADVLG 3058 Query: 1732 LRRIGIHDNFFAAGGDSIKAIQAAARMEKYNLRLEVKHLFQYQTIGEVSKKVQDRAGHAG 1791 ++++G DNFF GGDSIKAIQ + R+ L +K LFQY TI E + +V + + Sbjct: 3059 IKQVGTQDNFFELGGDSIKAIQVSTRLNASGWTLAMKELFQYPTIEEAALRVIPNSRESE 3118 Query: 1792 YGAVTGEAGLVPIQSWMVEHCRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALR 1851 G V GE L PIQ W + H N + +L+RE GF E +R+ F +I+ HHDALR Sbjct: 3119 QGVVEGEIALTPIQKWFFANNFTDRHHWNQAVMLFREDGFDEGLVRQAFQQIVEHHDALR 3178 Query: 1852 MVFREQNRQMLQHNRGLDGELFDFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKGPLVKL 1911 MV+++++ + Q NRGL E F FY DL + + S+DLE GPLV + Sbjct: 3179 MVYKQEDGAIKQINRGLTDERFRFYSYDLKNHANSEARILELSDQIQSSIDLEHGPLVHV 3238 Query: 1912 ALIRAGYGEHLLIVIHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLPPKTAPFLQWSNH 1971 AL G+HLL+ IH +++D +SWRI+ EDF++AY+Q L+ ++I LP KT F W+ Sbjct: 3239 ALFATKDGDHLLVAIHHLVVDGVSWRILFEDFSSAYSQALHQQEIVLPKKTDSFKDWAAQ 3298 Query: 1972 LHEYADSIELLREQPYWDQVE-SIKAEPLPTDYKADEARVRDNLTLYQAFDCTETEQVMS 2030 L +YADS ELLRE YW +E + LPTD+ + + + TL A +TE ++ Sbjct: 3299 LQKYADSDELLREVAYWHNLETTTTTAALPTDFVTADRKQKHTRTLSFALTVPQTENLLR 3358 Query: 2031 SIRSNPHFTTESIMLTALALTIRAWTGNAAVVVNLGNHGRDMDSKDIDTYRTVGRFSILY 2090 + H ++LTAL L ++ W VV+NL HGR+ +++ RT+G F+ Y Sbjct: 3359 HVHHAYHTEMNDLLLTALGLAVKDWAHTNGVVINLEGHGREDIQNEMNVTRTIGWFTSQY 3418 Query: 2091 PVALQLPESRNIDLCLEYVKEYLSGIPKQGGGYGVLKYLSSH--QEGIRFRLNPELSFNY 2148 PV L + ++ ++ ++ KE L IPK+G GY +L+ L++ Q + F L PE+SFNY Sbjct: 3419 PVVLDMEKAEDLPYQIKQTKENLRRIPKKGIGYEILRTLTTSQLQPPLAFTLRPEISFNY 3478 Query: 2149 MGQFDAEFNTSTFRISPLSGGEDRSGEEIWSYKLKFISFIRMNQLNIGIEYNQQQYARET 2208 +GQF+++ T F SPL G+ S E + L + I +L I + Y++ QY +T Sbjct: 3479 LGQFESDGKTGGFTFSPLGTGQLFSPESERVFLLDISAMIEDGELRISVGYSRLQYEEKT 3538 Query: 2209 VNALLQQYMEYL 2220 + +L Y ++L Sbjct: 3539 IASLADSYRKHL 3550 Score = 811 bits (2096), Expect = 0.0, Method: Compositional matrix adjust. Identities = 482/1408 (34%), Positives = 754/1408 (53%), Gaps = 43/1408 (3%) Query: 675 VWGAVLGMNPMSVTADFYEIGGDSIIAIEIVNTLNTIMGLSLQVPVLFEHSNIERLAAYI 734 +W +LG++P+ + F+ +GG S+ AI++++ + + + VLFE I+ LAAY+ Sbjct: 984 IWEQILGVSPIGIQDHFFTLGGHSLKAIQLISRIQKECQADVPLRVLFEQPTIQALAAYV 1043 Query: 735 EGQAGTDKDTRGNSAIPRIAAAEHYEVSSSQKRIYILNQLNARSTSYNIPLFVMMEGPLD 794 EG + AIP+ +Y VSS+QKR+ ILNQL+ ST YN+P+ +++EG LD Sbjct: 1044 EG-----GEESAYLAIPQAEPQAYYPVSSAQKRMLILNQLDPHSTVYNLPVAMILEGTLD 1098 Query: 795 EGRLEHSFEALIQRHEVLRTSFSFVNKELVQAVDDHVHLAVEKYHADDETDLDQITSQFI 854 + RLEH+ L+ RHE LRTSF +N E V + + HL + Y E ++++ F+ Sbjct: 1099 KARLEHAISNLVARHESLRTSFHTINGEPVSRIHEQGHLPI-VYLETAEEQVNEVILGFM 1157 Query: 855 RPFDLSKAPLIRAGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYEHNPLPELNI 914 +PFDL APL R GLV++ +N+H+L++D+ HII+DG S L+ + LY++ LPE I Sbjct: 1158 QPFDLVTAPLCRVGLVKLAENRHVLIIDMHHIISDGVSSQLILNDFSRLYQNKALPEQRI 1217 Query: 915 QFKDFAKWQNDLFKTDYMNKQKKYWLDVFSGELPILNLPVDYPRDSGQGDQGERLTCNAG 974 +KDFA W+ +T KQ+KYWLD F+GE+P+LNLP+DYPR + Q +GER Sbjct: 1218 HYKDFAVWEKAWTQTTDYQKQEKYWLDRFAGEIPVLNLPMDYPRPAVQSFEGERYLFRTE 1277 Query: 975 RELTQRLNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHKELEQMIGMF 1034 ++L + L + + K TTL+M LLAA++VLL K++GQ+D+++G+ AGR H + E M GMF Sbjct: 1278 KQLLESLQDVAQKTGTTLYMVLLAAYHVLLSKYSGQDDVMIGTVTAGRVHPDTESMTGMF 1337 Query: 1035 VNTLALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNLSGTALFNVM 1094 VNTLA+RN+ + F++FL VK+N L A+EH YPFEELV+ L + RN S LF+ + Sbjct: 1338 VNTLAMRNQSAPTKTFRQFLLEVKDNTLAAFEHGQYPFEELVEKLAIQRNRSRNPLFDTL 1397 Query: 1095 FVLQVMDNPAFEVNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAAKLFKRSTIE 1154 F+LQ MD E++G+ PY + AKFDL+L+ L F F + KLF R TIE Sbjct: 1398 FILQNMDADLIELDGLTVTPYVPEGEVAKFDLSLEASENQAGLSFCFEFCTKLFARETIE 1457 Query: 1155 SFARRFLRVLEQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAYNTKTIVEMFEAQA 1214 + +L++L+ V A + I++L E +++ + T+ ++FE QA Sbjct: 1458 RMSLHYLQILQAVSANTEQELAQIEMLTAHEKQELLVHFNDTAALYPAESTLSQLFEDQA 1517 Query: 1215 ARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERSTNFAVGIMGV 1274 + P+ AV D+ LTYRELNE+ANQLA L G ++ VGI+A+RS A+GI+ + Sbjct: 1518 QKTPEQTAVVFGDKRLTYRELNERANQLAHTLRAKGVQAEQSVGIMAQRSLEMAIGIIAI 1577 Query: 1275 LKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLEEVAGNSGEQ 1334 LK+G AY+PI+P YP ER +MLED +VLT + + + L+E S + Sbjct: 1578 LKAGGAYVPIDPDYPNERIAYMLEDCRR-LVLTQQQLAEKMTANVECLYLDEEGSYSPQT 1636 Query: 1335 GNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTN-LAEALDEKIYSLHGPNLNVALL 1393 N+E +A LAY+IYTSG+TG+PKGVM+EHR + N + DE S+ L Sbjct: 1637 ENIEPIHTAADLAYIIYTSGTTGRPKGVMVEHRGIVNSVTWNRDEFALSVRDSG---TLS 1693 Query: 1394 APFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPAYLRLLAE 1453 F FDA F+ + G + ++P +D I L + P+ + + E Sbjct: 1694 LSFAFDAFALTFFTLIVSGSTVVLMPDHEAKDPIALRNLIAAWECSYVVFVPSMFQAILE 1753 Query: 1454 TSLCARI-GVAHFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPTECCVDATAFTIKP 1512 S A I + ++GGE LS V+ A H + N YGPTE V AT Sbjct: 1754 CSTPADIRSIQAVMLGGEKLSPKLVQ---LCKAMHPQMSVMNAYGPTESSVMATYL---- 1806 Query: 1513 EETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYCNNKALTSSRF 1572 +T Q + IG PI N ++YI+D+ +++P GV+GE+ IGGHG+ARGY LT+ +F Sbjct: 1807 RDTQPDQPITIGRPIANTAIYIVDQHHQLLPVGVVGEICIGGHGLARGYWKKPELTAEKF 1866 Query: 1573 VEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHRLLSCDGVQA 1632 V + PG MYKTGD+G+W DG I F GR D Q+K+RG+RIE+ EI LL+ D Sbjct: 1867 VANPAVPGERMYKTGDLGRWLHDGTIDFIGRVDDQIKVRGYRIEVGEIEAVLLAYDQTNE 1926 Query: 1633 AVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMPVDQIPMTANGK 1692 A+V+ +D R + YL AYV + LR +L LP YM+P ++ +D P+T NGK Sbjct: 1927 AIVVAYQDDRGDSYLAAYVTGKTAIEESELRAHLLRELPAYMVPTYLIQLDAFPLTPNGK 1986 Query: 1693 ADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFAAGGDSIKAI 1752 D LP P+ Y AP E L +W L + +G+ D+FF GG S+KA+ Sbjct: 1987 VDRKALPKPEGKPATGAAYVAPATEVEAKLVAIWENALGISGVGVLDHFFELGGHSLKAM 2046 Query: 1753 QAAARMEK-YNLRLEVKHLFQYQTIGEVSKKVQDRAGHAGYGAVTGEA-GLVPIQS---- 1806 A++ + + + L +K F TI ++++ ++ AG E P+ S Sbjct: 2047 TVVAQVHREFQIDLLLKQFFAAPTIRDLARLIEHSEQAAGAAIQPAEPQAYYPVSSAQQR 2106 Query: 1807 -WMVEHCRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALRMVFREQNRQMLQHN 1865 +++ N ++ E + + ++ HD LR F +++Q Sbjct: 2107 MYLLHQLEGAGISYNTPGIIMLEGKLDREQLANALQALVDRHDILRTSFEMVGDELVQ-- 2164 Query: 1866 RGLDGELFDFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKGPLVKLALIRAGYGEHLLIV 1925 ++ D +++ + ++ DL PL++++L++ HLL+ Sbjct: 2165 -----KIHDRVAVNMEYVTAEEQQIDDLFHAFVRPFDLSVPPLLRMSLVKLADERHLLLY 2219 Query: 1926 -IHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLPPKTAPFLQWSNHLHEYADSIELLRE 1984 +H + D S I+ ++ Y E + + F W LHE +D+ + ++ Sbjct: 2220 DMHHIAADAASITILFDELAELYQ---GRELPEMRIQYKDFAVWQKALHE-SDAFK--QQ 2273 Query: 1985 QPYWDQV--ESIKAEPLPTDYKADEARVRDNLTLYQAFDCTETEQVMSSIRSNPHFTTES 2042 + YW +I A +PTD+ + + + D E + + ++ + T Sbjct: 2274 EAYWLSTFAGNITAVDVPTDFPRPAVKSFAGGQVTLSMD-QELLSALHELAAHTNTTLFM 2332 Query: 2043 IMLTALALTIRAWTGNAAVVVNLGNHGR 2070 ++L A + + + G ++V GR Sbjct: 2333 VLLAAYNVLLAKYAGQDDIIVGTPISGR 2360 Score = 508 bits (1308), Expect = e-142, Method: Compositional matrix adjust. Identities = 375/1294 (28%), Positives = 619/1294 (47%), Gaps = 96/1294 (7%) Query: 759 YEVSSSQKRIYILNQLNARSTSYNIPLFVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSF 818 Y ++ Q+ + L+ S+ + + + ++G LD G S L++R++V RT F + Sbjct: 13 YALTPMQEGMLFHALLDQEHNSHLVQMSISLQGDLDVGLFTDSLHVLVERYDVFRTLFLY 72 Query: 819 VN-KELVQAVDDHVHLAVEKY--HADDETDLDQITSQFIRP-----FDLSKAPLIRAGLV 870 K+ +Q V + +E Y A DE++ +Q+ R F L+K PL+R L Sbjct: 73 EKLKQPLQVVLKQRPIPIEFYDLSACDESEKQLRYTQYKRADQERTFHLAKDPLMRVALF 132 Query: 871 EIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLY----EHNPLPELNIQ-FKDFAKWQND 925 ++ ++ + ++ HI+ DG ++ +++ +Y L +Q + F W Sbjct: 133 QMSQHDYQVIWSFHHILMDGWCFSIIFDDLLAIYLSLQNKTALSLEPVQPYSRFINWLEK 192 Query: 926 LFKTDYMNKQKKYWLDVFSGELPILNLPVDYPRDSGQGDQGERLTCNAGRELTQRLNEYS 985 K +N YW D LP + Q + + R LT++L + Sbjct: 193 QNKQAALN----YWSDYLEAYEQKTTLP-KKEAAFAKAFQPTQYRFSLNRTLTKQLGTIA 247 Query: 986 SKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHK--ELEQMIGMFVNTLALRNR 1043 S+ + TL + + VLL K+ D++ GS ++GR +++M+G+F+NT+ R + Sbjct: 248 SQNQVTLSTVIQTIWGVLLQKYNAAHDVLFGSVVSGRPTDIVGIDKMVGLFINTIPFRVQ 307 Query: 1044 PSAHMVFKEFLAGVKENALQAYEHQDYPF----------EELVDHLNMDRNLSGTALFNV 1093 A F E L V + LQ+ ++ P +EL+DHL + N L Sbjct: 308 AKAGQTFSELLQAVHKRTLQSQPYEHVPLYDIQTQSVLKQELIDHLLVIENYP---LVEA 364 Query: 1094 MFVLQVMDNPAFEVNGMH-YAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAAKLFKRST 1152 + + F + + + P +DL + V P +EL F F Y A LF Sbjct: 365 LQKKALNQQIGFTITAVEMFEP-------TNYDLTVMVMPK-EELAFRFDYNAALFDEQV 416 Query: 1153 IESFARRFLRVLEQVVALEHVLIGDIDVLDREELRDI---RRYGQAGLPAAYNTKTIVEM 1209 ++ A ++ + V V + I +L E + R A PAA T+ E+ Sbjct: 417 VQKLAGHLQQIADCVANNSGVELCQIPLLTEAETSQLLAKRTETAADYPAA----TMHEL 472 Query: 1210 FEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERSTNFAV 1269 F QA + P+ +AV D+ LTYREL+E++NQLAR L + G +VG + +RS + V Sbjct: 473 FSRQAEKTPEQVAVVFADQHLTYRELDEKSNQLARFLRKKGIGTGSLVGTLLDRSLDMIV 532 Query: 1270 GIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLEEVAG 1329 GI+GVLK+G A++PI+P P ER +ML S +V+T R + I + Sbjct: 533 GILGVLKAGGAFVPIDPELPAERIAYMLTHSRVPLVVTQNHLRAKVTTPTETIDINTAVI 592 Query: 1330 NSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAE-ALDEKIYSLHGPNL 1388 + +E+ L Y+IYTSG+TG+PKGVM+EHR++ NL D+ + H L Sbjct: 593 GEESRAPIESLNQPHDLFYIIYTSGTTGQPKGVMLEHRNMANLMHFTFDQTNIAFHEKVL 652 Query: 1389 NVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPAYL 1448 + FD ++IFS L G L ++ ++R+ V +L + ++ +I I ++L Sbjct: 653 QYTTCS---FDVCYQEIFSTLLSGGQLYLITNELRRHVEKLFAFIQEKQISILSLPVSFL 709 Query: 1449 RLLAETSLCARI---GVAHFIIGGEALSIA-EVKRFYTSFANHKPPYITNVYGPTECCVD 1504 + + A+ V H I GE L + E++++ H+ ++ N YGP+E V Sbjct: 710 KFIFNEQDYAQSFPRCVKHIITAGEQLVVTHELQKY---LRQHRV-FLHNHYGPSETHV- 764 Query: 1505 ATAFTIKPEETGQIQEMP-IGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYCN 1563 T T+ P + I E+P IG PI N +YILDE ++ P G++GELYI G V RGY + Sbjct: 765 VTTCTMDPGQA--IPELPPIGKPISNTGIYILDEGLQLKPEGIVGELYISGANVGRGYLH 822 Query: 1564 NKALTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHR 1623 LT+ +F+++ Y PG MY+TGD+ W DG + F GR DHQVKIRG RIEL EI R Sbjct: 823 QPELTAEKFLDNPYQPGERMYRTGDLALWLPDGQLEFLGRIDHQVKIRGHRIELGEIESR 882 Query: 1624 LLSCDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMPVD 1683 LL+ ++ AVV+ + D+ +LCAYVV + +R YL + LP+YMIP + ++ Sbjct: 883 LLNHPAIKEAVVIDRADETGGKFLCAYVVLQKALSDEEMRAYLAQALPEYMIPSFFVTLE 942 Query: 1684 QIPMTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFA 1743 +IP+T NGK D LP P+ Y AP E+ L +W ++L + IGI D+FF Sbjct: 943 RIPVTPNGKTDRRALPKPEGSAKTKADYVAPTTELEQKLVAIWEQILGVSPIGIQDHFFT 1002 Query: 1744 AGGDSIKAIQAAARMEK-YNLRLEVKHLFQYQTIGEVSKKVQ----------DRAGHAGY 1792 GG S+KAIQ +R++K + ++ LF+ TI ++ V+ +A Y Sbjct: 1003 LGGHSLKAIQLISRIQKECQADVPLRVLFEQPTIQALAAYVEGGEESAYLAIPQAEPQAY 1062 Query: 1793 GAVTGEAGLVPIQSWMVEHCRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALRM 1852 V+ + I + + H NL + E + + + ++ H++LR Sbjct: 1063 YPVSSAQKRMLILNQLDPHSTV----YNLPVAMILEGTLDKARLEHAISNLVARHESLRT 1118 Query: 1853 VFREQNRQMLQHNRGLDGELFDFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKGPLVKLA 1912 F N + + G L YL + E+ DL PL ++ Sbjct: 1119 SFHTINGEPVSRIHE-QGHLPIVYL------ETAEEQVNEVILGFMQPFDLVTAPLCRVG 1171 Query: 1913 LIRAGYGEHLLIV-IHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLPPKTAPFLQWSNH 1971 L++ H+LI+ +H +I D +S ++IL DF+ Y ++ LP + + ++ Sbjct: 1172 LVKLAENRHVLIIDMHHIISDGVSSQLILNDFSRLY------QNKALPEQRIHYKDFAVW 1225 Query: 1972 LHEYADSIELLREQPYW-DQVE-SIKAEPLPTDY 2003 + + + +++ YW D+ I LP DY Sbjct: 1226 EKAWTQTTDYQKQEKYWLDRFAGEIPVLNLPMDY 1259 >sp|O68008|BACC_BACLI Bacitracin synthetase 3 (BA3) [Includes: ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); ATP-dependent D-phenylalanine adenylase (D-PheA) (D-phenylalanine activase); ATP-dependent histidine adenylase (HisA) (Histidine activase); ATP-dependent D-aspartate adenylase (D-AspA) (D-aspartate activase); ATP-dependent asparagine adenylase (AsnA) (Asparagine activase); Aspartate racemase ; Phenylalanine racemase [ATP hydrolyzing] ] pir||T31679 bacitracin synthetase 3 - Bacillus licheniformis gb|AAC06348.1| bacitracin synthetase 3; BacC [Bacillus licheniformis] Length = 6359 Score = 1074 bits (2778), Expect = 0.0, Method: Compositional matrix adjust. Identities = 584/1564 (37%), Positives = 896/1564 (57%), Gaps = 24/1564 (1%) Query: 666 SKAEISVGQVWGAVLGMNPMSVTADFYEIGGDSIIAIEIVNTLNTIMGLSLQVPVLFEHS 725 ++ E + +W VLG+ + ++ +F+E+GG S+ A + L+ M + + + LFE Sbjct: 3500 NRTEEKLVSIWEDVLGIENIGISHNFFELGGHSLKAAALTAKLHKEMKIEVPLRQLFETP 3559 Query: 726 NIERLAAYIEGQAGTDKDTRGNSAIPRIAAAEHYEVSSSQKRIYILNQLNARSTSYNIPL 785 I+ + +IE + ++I + E+Y +SS+Q+R+YILNQ+ SYN+P Sbjct: 3560 TIKDIGDFIESMKESPY-----ASITQAEEKEYYALSSAQRRLYILNQIEPGGLSYNMPF 3614 Query: 786 FVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSFVNKELVQAVDDHVHLAVEKYHADDETD 845 + + G D R E +F LI+RHE LRT+F V+ E VQ ++ V V KY + Sbjct: 3615 AMKIAGDFDVDRFEDAFRQLIERHEALRTAFVMVDGEPVQKIEKEVDFKV-KYGRLGQDP 3673 Query: 846 LDQITSQFIRPFDLSKAPLIRAGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYE 905 L++ FI+PF L KAPL+RA +++ ++H+LMLD+ HII+DG S+ + +E+ LYE Sbjct: 3674 LEEKIKAFIKPFALEKAPLLRAEVLKASGDEHVLMLDMHHIISDGVSMAIFTRELAELYE 3733 Query: 906 HNPLPELNIQFKDFAKWQNDLFKTDYMNKQKKYWLDVFSGELPILNLPVDYPRDSGQGDQ 965 LP L IQ+KDF++WQ ++ D + +Q+ YWL+VF GE+P+LNLP D R + + Sbjct: 3734 GKTLPPLTIQYKDFSEWQKLFYQKDEVKRQEDYWLNVFQGEVPVLNLPADEKRPQKRSIE 3793 Query: 966 GERLTCNAGRELTQRLNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHK 1025 G+ + E + LN+ + + T++M LLA + LL K+TGQEDI+VGSPIAGR H Sbjct: 3794 GDIVQFEIDGETSAMLNKLAKENGATMYMLLLAGYTTLLAKYTGQEDIVVGSPIAGRHHS 3853 Query: 1026 ELEQMIGMFVNTLALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNL 1085 +L+ +IG+F+NTLA+RN P M F ++L VKE AL+AYE+QDYPF+ELV+ L++ R++ Sbjct: 3854 DLKHVIGLFINTLAMRNHPKGDMPFADYLKEVKETALKAYENQDYPFDELVEKLDVKRDM 3913 Query: 1086 SGTALFNVMFVLQVMDNPAFEVNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAA 1145 S LF+ M VLQ D +++G+ + P +KFDL L + ++ F Y+ Sbjct: 3914 SRHPLFDTMLVLQNFDGDEADIDGLTFQPLQTEVNISKFDLTLTAAETNEGIQCVFNYST 3973 Query: 1146 KLFKRSTIESFARRFLRVLEQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAYNTKT 1205 KLFKRSTIE A + +L++ H+ + D+++L EE+ + Q +T Sbjct: 3974 KLFKRSTIERMAGHLINILKEAANDPHMPLSDVNMLSDEEMNALLDQNQGKQADYPQDQT 4033 Query: 1206 IVEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERST 1265 + ++FE QA + P+ AV D LTYRELNE+ANQLAR+L GA D+ V I+ E S Sbjct: 4034 VHQLFEQQADKTPEQTAVVYADEKLTYRELNERANQLARLLRDKGADADQPVAIMIEPSL 4093 Query: 1266 NFAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLE 1325 + ++ VLK+GAAY+PIEP +R +L DS A ++L + + ++ + + Sbjct: 4094 EMIISMLAVLKAGAAYVPIEPEQLAKRTNEILSDSRAAILLVKGSVKENVAFAGEIVNVA 4153 Query: 1326 EVAGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKIYSLHG 1385 + ++ NL A+ SAD AY+IYTSGSTGKPKGV + H +V N ++ + Sbjct: 4154 DGLIDAKVASNLSASGSADQNAYIIYTSGSTGKPKGVFVRHGNVVNYTTWFMKE--AGLT 4211 Query: 1386 PNLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTP 1445 N L++ + FD IFSA L G L+I + + + +Y K+N I TP Sbjct: 4212 ENDKAMLVSSYAFDLGYTSIFSALLSGSELHIARKECYTNAHRALKYIKENGITYIKLTP 4271 Query: 1446 AYLRL------LAETSLCARIGVAHFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPT 1499 + + + CA + + ++GGE ++ +V+ FY + +H + N YGPT Sbjct: 4272 SLFNIFVNDPGFSAEKPCATLRLV--VLGGEMINTRDVETFYNQYPDH---VVMNHYGPT 4326 Query: 1500 ECCVDATAFTIKPEETGQIQEMP-IGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVA 1558 E + + I PE +E P IG PI N + Y+LDE +++P GV GEL I G GV Sbjct: 4327 ETTIGSVFKVIDPEHLDSFKECPVIGTPIHNTNAYVLDENMKLLPEGVYGELCIAGAGVT 4386 Query: 1559 RGYCNNKALTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELD 1618 GY N T +F+E+ + P MY+TGD+ + DG I AGR D QVK+RG+RIE + Sbjct: 4387 GGYVNRPDETKEKFIENPFAPHTKMYRTGDLARRLSDGNIELAGRIDTQVKVRGYRIEPE 4446 Query: 1619 EIRHRLLSCDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRV 1678 EI++RLL+ D ++ A + ++D + LCAY E +R YL LP+YMIP Sbjct: 4447 EIKNRLLAHDDIKEAFIAAREDHKGAKQLCAYFTADAELPFEDIRTYLMHELPEYMIPSS 4506 Query: 1679 IMPVDQIPMTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIH 1738 + ++++P++ANGK DT+ LP+PQ ++ Y PRN TEE L +W EVL + +IGI Sbjct: 4507 FVQIEKMPLSANGKIDTAALPEPQPGKETE--YEPPRNETEEKLVQIWEEVLGIDKIGIT 4564 Query: 1739 DNFFAAGGDSIKAIQAAARMEKYNLRLEVKHLFQYQTIGEVSKKVQDRAGH-AGYGAVTG 1797 +FFAAGGDSIKA+Q +R+ + L LE+K LF I +S+ V+ + A Y V G Sbjct: 4565 HHFFAAGGDSIKALQMISRLSREGLSLEMKDLFANPQIKSLSRYVKAESDKSASYETVEG 4624 Query: 1798 EAGLVPIQSWMVEHCRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALRMVFREQ 1857 E L PIQ + H N + +LYR+ GF E +++VF EII+HHDALR VF E+ Sbjct: 4625 EVLLTPIQQEYFSLNKTDRNHYNHAVMLYRKNGFDESIVKRVFKEIIKHHDALRTVFTEE 4684 Query: 1858 NRQMLQHNRGLDGELFDFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKGPLVKLALIRAG 1917 + +++Q+NRG D +LFD ++ D++ ++ S+D+E GPLVKLA+ + Sbjct: 4685 DGKIIQYNRGPDKQLFDLFVYDVSSENDQPQKVYQLATELQQSIDIETGPLVKLAVFKTN 4744 Query: 1918 YGEHLLIVIHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLPPKTAPFLQWSNHLHEYAD 1977 G+HLLI+IH +++D +SWRI+ ED Y+QL N E + PKTA + ++ H+ EYA Sbjct: 4745 NGDHLLIIIHHLVVDGISWRILFEDLAIGYSQLANGEKVEFYPKTASYQAYARHIAEYAK 4804 Query: 1978 SIELLREQPYWDQVESIKAEPLPTDYKADEARVRDNLTLYQAFDCTETEQVMSSIRSNPH 2037 S++LL E+ YW + + E L + A +V D+ T + ET++++ H Sbjct: 4805 SVKLLSEKQYWLKAIAEGVEFLDMNENAGAFKVEDSRTFSTELEKEETKRLLRETNRAYH 4864 Query: 2038 FTTESIMLTALALTIRAWTGNAAVVVNLGNHGRDMDSKDIDTYRTVGRFSILYPVALQLP 2097 I++TAL + R G + + L HGR+ + ID RTVG F+ YPV + L Sbjct: 4865 TEINDILITALLVAARDMNGQNQLRITLEGHGREQVADGIDISRTVGWFTSKYPVFIDLG 4924 Query: 2098 ESRNIDLCLEYVKEYLSGIPKQGGGYGVLKYLSSHQEGIRFRLNPELSFNYMGQFDAEFN 2157 + ++ ++ VKE+L +P +G GYG+LKYL+ E + +P L FNY+GQ D + N Sbjct: 4925 QETDMSRTIKMVKEHLRNVPNKGIGYGILKYLTRDSEIAKGAASPIL-FNYLGQLDEDIN 4983 Query: 2158 TSTFRISPLSGGEDRSGEEIWSYKLKFISFIRMNQLNIGIEYNQQQYARETVNALLQQYM 2217 + F S LS GE + L+ + + +L I YN + Y+ + V A Q Y Sbjct: 4984 SGEFSSSHLSPGEAAGKGITREHPLEINAVVFRGKLAIQTTYNTRAYSEDVVRAFAQNYK 5043 Query: 2218 EYLK 2221 E LK Sbjct: 5044 EALK 5047 Score = 1018 bits (2633), Expect = 0.0, Method: Compositional matrix adjust. Identities = 596/1661 (35%), Positives = 919/1661 (55%), Gaps = 78/1661 (4%) Query: 587 ICSLYEKGGEVDWESL--YEGEKRGKISIPVYPFLKERHW---VNAPRRKTAEPDEEEQE 641 IC+ E+ + L + GEK + IP Y F+K N + A P+ + Sbjct: 895 ICAYITANREISLDELKGFLGEKLPEYMIPAY-FVKMDKLPLTKNGKVDRKALPEPDRTA 953 Query: 642 GLWQNSLEAAAAGIQLEGRDSGRYSKAEISVGQVWGAVLGMNPMSVTADFYEIGGDSIIA 701 G +N EA ++ E + +W +L + + F+E+GG S+ A Sbjct: 954 GA-ENEYEAPR-------------NETEEKLAAIWRDILKVEKSGINDHFFEMGGHSLKA 999 Query: 702 IEIVNTLNTIMGLSLQVPVLFEHSNIERLAAYIEGQAGTDKDTRGNSAIPRIAAAEHYEV 761 + + + + + +F+ I+ L YI + KD+ S+I ++ E+Y + Sbjct: 1000 AAMAARIRKELKAEIPLGQIFKTPTIKGLGEYIR----STKDSV-YSSIQKVEEKEYYRL 1054 Query: 762 SSSQKRIYILNQLNARSTSYNIPLFVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSFVNK 821 SS+QKR+YIL+Q+ SYNIP + ++G D R E++ + +IQRHE LRTSF + Sbjct: 1055 SSAQKRLYILDQIEGSGLSYNIPFTMKVKGRFDIRRFENALKTIIQRHEALRTSFLMADG 1114 Query: 822 ELVQAVDDHVHLAVEKYHADDETDLDQITSQFIRPFDLSKAPLIRAGLVEIRKNKHLLML 881 E VQ ++ V ++ K + +I QF+RPFDL KAPL R +V++ +H+++ Sbjct: 1115 EPVQKIEKEVDFSI-KCSKIQSLSIQEIIKQFVRPFDLKKAPLFRTEVVKVDDEEHIILF 1173 Query: 882 DVQHIIADGSSIPLLQKEIIHLYEHNPLPELNIQFKDFAKWQNDLFKTDYMNKQKKYWLD 941 D+ HII+DG+S+ +L KEI LY L L++Q+KD+++WQ D ++ D M +QK+YWL+ Sbjct: 1174 DMHHIISDGASMGVLTKEICDLYGGKELKPLSLQYKDYSEWQRDFYQKDEMKRQKEYWLN 1233 Query: 942 VFSGELPILNLPVDYPRDSGQGDQGERLTCNAGRELTQRLNEYSSKEKTTLFMTLLAAFN 1001 +F GE+P+LN+P DYPR +G+R+ ELT++L + T++M LLAA+ Sbjct: 1234 IFKGEIPVLNMPTDYPRPQMHSVEGDRIGFAIDGELTKKLKRIAKDNGATMYMLLLAAYT 1293 Query: 1002 VLLFKHTGQEDIIVGSPIAGRKHKELEQMIGMFVNTLALRNRPSAHMVFKEFLAGVKENA 1061 VLL ++GQED+I+G+PI GRKH EL+ +IGMFVNTLA+RN P F E+L VKE A Sbjct: 1294 VLLRTYSGQEDVIIGTPIQGRKHHELKHVIGMFVNTLAMRNHPKGDKTFAEYLQDVKETA 1353 Query: 1062 LQAYEHQDYPFEELVDHLNMDRNLSGTALFNVMFVLQVMDNPAFEVNGMHYAPYPYHNKT 1121 L+AYE+QDY F++LV+ L+++R++S LF+ MFVLQ ++ E+ G+ + P+ Sbjct: 1354 LKAYENQDYQFDDLVEQLDLERDMSRNPLFDTMFVLQNLEKADAEIEGLTFEPFESDIHI 1413 Query: 1122 AKFDLALQVFPGLDELKFEFTYAAKLFKRSTIESFARRFLRVLEQVVALEHVLIGDIDVL 1181 +KFDL L +++F+ Y KLFKR T+E A F+RVLE + + I+ + Sbjct: 1414 SKFDLTLSAIEKDSKIEFDLEYCTKLFKRETVERMAAHFVRVLEDISKRTDKRLDQIEAM 1473 Query: 1182 DREELRDIRRYGQAGLPAAYNTKTIVEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQ 1241 +E + A KTI ++F +A PD AV D++LTYR+L+E++NQ Sbjct: 1474 SEDEKNTLLYRFNDTKTDAPTDKTICQLFAERAETSPDKTAVVFEDQTLTYRQLHERSNQ 1533 Query: 1242 LARVLIRNGACKDRVVGIIAERSTNFAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSG 1301 LAR L G D VGI+ +RS +G++G+LK+G AYLP++PAYP +R +++L DS Sbjct: 1534 LARFLREKGVQPDTAVGIMVDRSPEMIIGLLGILKAGGAYLPLDPAYPEDRIKYILGDSQ 1593 Query: 1302 ACMVLTDTA--HRRSLQHGIREICLE----EVAGNSGEQGNLEATASADSLAYVIYTSGS 1355 +L++ A +R+ I ++ ++A Q LE + + LAY+IYTSGS Sbjct: 1594 TKFLLSEEALIKKRAFIKEADMINIDIHDKQIAAQDAAQ--LEPVSRSGDLAYIIYTSGS 1651 Query: 1356 TGKPKGVMIEHRSVTNLAEALDEKIYSLHGPNLNVALLAPFVFDASVKQIF------SAF 1409 TGKPKGV+IE + ++NL A+ + ++ G V A FDAS +IF SA Sbjct: 1652 TGKPKGVLIEQKGLSNLVSAVVKLMHLNTGS--RVIQFASLSFDASAFEIFPALAAGSAL 1709 Query: 1410 LLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPAYLRLLAETSLCARIGVAHFIIGG 1469 +LG ++PG L + +Q I + P L +L E+ L + + G Sbjct: 1710 VLGRQEEMMPGQ------PLTSFLRQYNITHATLPPTVLDVLNESGLE---NLKVIVSAG 1760 Query: 1470 EALSIAEVKRFYTSFANHKPPYITNVYGPTECCVDATAFTIKPEETGQIQEMPIGAPIKN 1529 A S KR+ + N YGPTE V ATA E +G+ IG+PI N Sbjct: 1761 SACSEELAKRWSGN------RLFINAYGPTETTVCATAGIY--EGSGRPH---IGSPIAN 1809 Query: 1530 CSVYILDEQKRMVPRGVLGELYIGGHGVARGYCNNKALTSSRFVEDIYHPGMYMYKTGDM 1589 +VY+LD+ ++ VP GV+GEL +GG +ARGY N LT+ +F+ + G +Y+TGD+ Sbjct: 1810 TNVYVLDQNQKPVPTGVVGELCVGGMSLARGYLNRPELTAEKFISHPFASGERLYRTGDL 1869 Query: 1590 GKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHRLLSCDGVQAAVVLVQKDQRQEPYLCA 1649 +W DG + F GR DHQVKIRG+RIEL EI ++LL D + A V+ +KD YLCA Sbjct: 1870 ARWLPDGHLEFLGRIDHQVKIRGYRIELGEIENQLLKLDKIDEAAVIARKDDDHSDYLCA 1929 Query: 1650 YVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMPVDQIPMTANGKADTSQLPDPQEMRDHSL 1709 Y+V +++ + +L + LP YMIP + +D++P+T+N K D LP P Sbjct: 1930 YIVSKEDWTSTEISEWLEKELPHYMIPAYFVRLDKLPLTSNDKVDRKALPAPDRHVATGA 1989 Query: 1710 GYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFAAGGDSIKAIQAAARMEKYNLRLEVKH 1769 Y APRN TE L +W +VL IGI +FFAAGGDSIKA+Q +R+ + L+LE+K Sbjct: 1990 VYEAPRNDTEAKLVDIWRDVLGAGDIGISHHFFAAGGDSIKALQIVSRLSRLGLKLEMKD 2049 Query: 1770 LFQYQTIGEVSKKVQDRAGHAGYGA-VTGEAGLVPIQSWMVEHCRDTLQHRNLSFVLYRE 1828 LF I +++K V+ ++ VTG A L PIQ W + ++ L H N SFVL+R+ Sbjct: 2050 LFANPRIKDLAKYVKKQSQRKNANTIVTGHAELTPIQKWYFANNKEELDHFNQSFVLFRK 2109 Query: 1829 AGFGEDNIRKVFTEIIRHHDALRMVFREQNRQMLQHNRGLDGELFDFYLIDLADSPSFSE 1888 GF E ++K F +I+ HDALRM++ E+ +Q+NR +LFD + D+ +E Sbjct: 2110 GGFDESCVKKAFNKIMEQHDALRMIYEEKGGDFIQYNRSFREDLFDLDVYDVRGLDRQAE 2169 Query: 1889 EXXXXXXXXXXSMDLEKGPLVKLALIRAGYGEHLLIVIHQMIIDHLSWRIILEDFNTAYT 1948 + + KG LV L + RA G+HLLIVIH +++D +SWRI+ EDF T Y+ Sbjct: 2170 KVYELATSIQKLSSIRKGKLVHLGIFRADEGDHLLIVIHHLVVDGVSWRILFEDFETLYS 2229 Query: 1949 QLLNHEDIGLPPKTAPFLQWSNHLHEYADSIELLREQPYWDQVESIKAEPLPTDYKADEA 2008 Q L + + + KT + +++ L YA S L +E YW + + +P E Sbjct: 2230 QALKGQTLEIGYKTDSYQEFARRLKAYAHSRTLSKEAEYWRNIAKARVRFIPPKNVLKED 2289 Query: 2009 RVRDNLTLYQAFDCTETEQVMSSIRSNPHFTTE--SIMLTALALTIRAWTGNAAVVVNLG 2066 ++ TL T ++ + +N + TE I+LTAL R TG + V + Sbjct: 2290 VYENSTTLSIKLGKEATADLLRN--TNRAYNTEINDILLTALLTGARDITGENKLKVMME 2347 Query: 2067 NHGRDMDSKDIDTYRTVGRFSILYPVALQLPESRNIDLCLEYVKEYLSGIPKQGGGYGVL 2126 HGR+ + +D RT+G F+ +YPV L E + + ++ VKE L IP +G GYG+L Sbjct: 2348 GHGREDILEGVDITRTIGWFTTMYPVLLDAGEEKALSQQIKMVKETLRKIPNKGIGYGLL 2407 Query: 2127 KYLS-----SHQEGIRFRLNPELSFNYMGQFDAEFNTSTFRISPLSGGEDRSGEEIWSYK 2181 KY++ +++E R +SFNY+G DA+ N F S S GE G+ S+ Sbjct: 2408 KYMAEDPDFTNEEKAR------ISFNYLGDIDADMNRGEFSGSSFSEGESIGGKIARSHS 2461 Query: 2182 LKFISFIRMNQLNIGIEYNQQQYARETVNALLQQYMEYLKK 2222 ++ + + ++L I +NQ +Y ++T++ L Q E L++ Sbjct: 2462 IEINAIVMNHELVIHTTFNQMEYEKDTISRLNHQLKERLEQ 2502 Score = 549 bits (1414), Expect = e-154, Method: Compositional matrix adjust. Identities = 395/1359 (29%), Positives = 661/1359 (48%), Gaps = 100/1359 (7%) Query: 759 YEVSSSQKRIYILNQLNARSTSYNIPLFVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSF 818 Y +S+ QK + + S +Y + ++G +DE E S +++RHE+LR SF Sbjct: 9 YPLSNMQKGMLFHAMKDEASHAYFEQFIIELKGDVDERMFEESLNEVMKRHEILRASFHH 68 Query: 819 VNKELVQAVDDHVHLAVEKYHADDETDLDQITSQFI-----RPFDLSKAPLIRAGLVEIR 873 E + + H+ + D D + +++ + FDL+K L+RA L+ + Sbjct: 69 RLDEPLHVIIKDRHMKFDYLDIRGRHDQDGVLERYLAEDRQKGFDLAKDTLMRACLIRMS 128 Query: 874 KNKHLLMLDVQHIIADGSSIPLLQKEIIHLYE----------HNPLPELNIQFKDFAKWQ 923 + + + HI+ DG + ++ E++ +YE +P P + D+ KW Sbjct: 129 DDSYQFVWTYHHILLDGWCLGIILDELLTIYEMKRKGQNHQLEDPRP-----YSDYIKWL 183 Query: 924 NDLFKTDYMNKQKKYWLDVFSGELPILNLP-VDYPRDSGQGDQGERLTCNAGRELTQRLN 982 D K + + YW SG +LP + P ++G + + + C+ +ELT RL Sbjct: 184 EDQDKEE----AQSYWESYLSGYDQKNSLPKLRTPSETGFKRREKTIECS--KELTNRLI 237 Query: 983 EYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHK--ELEQMIGMFVNTLAL 1040 + +++ T+ L + + V+L K+ ED++ G+ ++GR + +E M+G+F+NT+ Sbjct: 238 KLANRNHVTINTVLQSIWGVILAKYNNSEDVVFGTVVSGRDAEVEGIETMVGVFINTIPT 297 Query: 1041 RNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNLSGTALFNVMFVLQVM 1100 R R +FK+ L + +AL++ + E+ + +L + +F + Sbjct: 298 RIRLDKDKLFKDVLRQTQADALESSRYNYMNLAEVQALSELKNDLIDHVM---VFENYAV 354 Query: 1101 DNPAFE-----------VNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAAKLFK 1149 D AFE V+G Y + + +A D D+LK F Y ++ Sbjct: 355 DQKAFEEKNDVGFEMVNVSGEEQTNYHF-SISAALD---------DQLKLLFIYDENVYD 404 Query: 1150 RSTIESFARRFLRVLEQVVALEHVLIGDIDVLDREE---LRDIRRYGQAGLPAAYNTKTI 1206 + IE+ + + V EQV E + DI+++ +EE + D + G P K + Sbjct: 405 TTIIETLEKHIITVAEQVAEDETQTLRDINLVSKEEQHRILDTFNDTKTGYP---KDKPL 461 Query: 1207 VEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERSTN 1266 E+FE QA + PDH A+ + +TYRELNE+ANQ AR+L G + + IIA+RS Sbjct: 462 HELFEEQAMKTPDHTALVFGAQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADRSFE 521 Query: 1267 FAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLEE 1326 +GI+G+LK+G AYLPI+P P R FML D+ A ++L + I L++ Sbjct: 522 MIIGIIGILKAGGAYLPIDPETPKHRIAFMLSDTKAGVLLAQGKAADGIDCEADIIHLDK 581 Query: 1327 VAGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKIYSLHGP 1386 + + L + + AY+IYTSGSTG PKGV+ H S + + + Y Sbjct: 582 GVADGFSKKRLSSVNDSGDTAYIIYTSGSTGMPKGVVTPHYSAARVVKNTN---YIDITE 638 Query: 1387 NLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPA 1446 + + L+ + FD SV IF A L G L ++ + + +LAE K+ ++ + T A Sbjct: 639 DDAILQLSNYSFDGSVFDIFGALLNGASLVLIEKETVLNTHELAEVIKKEQVSVMFITTA 698 Query: 1447 YLRLLAETSLCARIGVAHFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPTECCVDAT 1506 LA+ ++ + +GGE SI V++ K + +VYGPTE V AT Sbjct: 699 LFNTLADINIGCLAKLRKIFLGGERASIPHVRKVLNHVGRDK---LIHVYGPTESTVYAT 755 Query: 1507 AFTIKPEETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYCNNKA 1566 + I E + + +PIG+P+ N SV I+DE +++P GV GEL I G G+++GY N + Sbjct: 756 YYFIN-EIDDEAETIPIGSPLANTSVLIMDEAGKLLPIGVPGELCIAGDGLSKGYLNREE 814 Query: 1567 LTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHRLLS 1626 LT+ +F+ + PG +YKTGD+ KW DG I F GR DHQVKIRGFRIEL EI RL Sbjct: 815 LTAEKFIPHPFIPGERLYKTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEM 874 Query: 1627 CDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMPVDQIP 1686 + + +V V++D+ PY+CAY+ E L L+G+LGE LP+YMIP + +D++P Sbjct: 875 HEDINETIVTVREDEESRPYICAYITANREISLDELKGFLGEKLPEYMIPAYFVKMDKLP 934 Query: 1687 MTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFAAGG 1746 +T NGK D LP+P Y APRN TEE L +W ++L++ + GI+D+FF GG Sbjct: 935 LTKNGKVDRKALPEPDRTAGAENEYEAPRNETEEKLAAIWRDILKVEKSGINDHFFEMGG 994 Query: 1747 DSIKAIQAAARMEKYNLRLEVK--HLFQYQTI---GEVSKKVQDRAGHAGYGAVTG--EA 1799 S+KA AAR+ K L+ E+ +F+ TI GE + +D Y ++ E Sbjct: 995 HSLKAAAMAARIRK-ELKAEIPLGQIFKTPTIKGLGEYIRSTKDSV----YSSIQKVEEK 1049 Query: 1800 GLVPIQS-----WMVEHCRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALRMVF 1854 + S ++++ + N+ F + + F II+ H+ALR F Sbjct: 1050 EYYRLSSAQKRLYILDQIEGSGLSYNIPFTMKVKGRFDIRRFENALKTIIQRHEALRTSF 1109 Query: 1855 REQNRQMLQHNRGLDGELFDFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKGPLVKLALI 1914 + + +Q ++ E+ DF I + S S DL+K PL + ++ Sbjct: 1110 LMADGEPVQK---IEKEV-DFS-IKCSKIQSLS--IQEIIKQFVRPFDLKKAPLFRTEVV 1162 Query: 1915 RAGYGEHLLIV-IHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLPPKTAPFLQWSNHLH 1973 + EH+++ +H +I D S ++ ++ Y L P + + +S Sbjct: 1163 KVDDEEHIILFDMHHIISDGASMGVLTKEICDLYG------GKELKPLSLQYKDYSEWQR 1216 Query: 1974 EYADSIELLREQPYWDQV--ESIKAEPLPTDYKADEARVRDNLTLYQAFDCTETEQVMSS 2031 ++ E+ R++ YW + I +PTDY + + + A D T+++ Sbjct: 1217 DFYQKDEMKRQKEYWLNIFKGEIPVLNMPTDYPRPQMHSVEGDRIGFAIDGELTKKLKRI 1276 Query: 2032 IRSNPHFTTESIMLTALALTIRAWTGNAAVVVNLGNHGR 2070 + N T ++L A + +R ++G V++ GR Sbjct: 1277 AKDNGA-TMYMLLLAAYTVLLRTYSGQEDVIIGTPIQGR 1314 Score = 541 bits (1395), Expect = e-152, Method: Compositional matrix adjust. Identities = 411/1362 (30%), Positives = 676/1362 (49%), Gaps = 85/1362 (6%) Query: 752 RIAAAEHYEVSSSQKRIYILNQLNARSTSYNIPLFVMMEGPLDEGRLEHSFEALIQRHEV 811 R A + Y +++ QK + + S +Y + +EG +D LE SF +++RHE+ Sbjct: 2538 RSAIEKIYPLANMQKGMLFHAIEDHTSDAYFQQTVMDIEGYVDPAILEASFNDIMKRHEI 2597 Query: 812 LRTSFSF-VNKELVQAVD-----DHVHLAVEKYHADDETDLDQ--ITSQFIRPFDLSKAP 863 LR S+ + + +E Q + D + + K A + + + + FDLSK Sbjct: 2598 LRASYEYEIVEEPRQIIIENRSIDFTYFNIAKSSAQQQEMFIERLLNEDRKKGFDLSKDV 2657 Query: 864 LIRAGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYEH------NPLPELNIQFK 917 L+RA L++ + + L+ HI+ DG + ++ +E+ +YE+ +PL E + Sbjct: 2658 LMRAYLLKTAERSYRLVWSHHHILLDGWCLGIIMRELFVIYENRMNGKASPLKETK-PYS 2716 Query: 918 DFAKWQNDLFKTDYMNKQKKYWLDVFSGELPILNLPVDYPRD-SGQGDQGERLTCNAGRE 976 D+ KW L + D + ++YW + G LP R S + D+ E++ + ++ Sbjct: 2717 DYIKW---LERQD-QEEARQYWREYLKGYEEQAQLPTLTKRKKSSRYDRREKV-IHLSKQ 2771 Query: 977 LTQRLNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHK--ELEQMIGMF 1034 LT++L E ++K TL + + ++L ++T +D++ G+ ++GR+ +E MIG+F Sbjct: 2772 LTKQLKELAAKNSVTLHTVIQTIWGLMLTRYTKIDDVVFGTVVSGREANVDGIEDMIGLF 2831 Query: 1035 VNTLALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNLSGTALFNVM 1094 +NT+ R R + F + L V+E+A+Q+ + E+ ++ ++L L Sbjct: 2832 INTIPTRIRFNEQARFNDCLQKVQEDAIQSNRYNYMNLAEVQALSSLKKDLIDHILVFEN 2891 Query: 1095 FVLQVMD------NPAFEVNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAAKLF 1148 + D F+VN + A + TA ++ V PG +EL TY ++ Sbjct: 2892 YEADEQDFEESQMKTGFKVNEISAAE---QSITA---FSMSVTPG-EELTLVLTYDGNVY 2944 Query: 1149 KRSTIESFARRFLRVLEQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAY-NTKTIV 1207 R I + RV EQV A E+ I +ID+L EE R Y A Y KTI Sbjct: 2945 DRDIINNIEGHIKRVAEQVTANENRKIAEIDMLAEEE-RKTLLYEFNRTNADYPRNKTIH 3003 Query: 1208 EMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERSTNF 1267 ++FE QA R P H AV L+Y+ LNE++NQLA +L G D +VG++AERS Sbjct: 3004 QLFEEQAERTPGHTAVVFEKEELSYKALNERSNQLAGLLREKGVKPDMIVGVMAERSVEM 3063 Query: 1268 AVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLEEV 1327 VG++ VLK+G AYLPI+P YP +R R+M+EDSG ++L + + ++ + + Sbjct: 3064 IVGMLAVLKAGGAYLPIDPEYPEDRIRYMIEDSGISILLKKADKQIDVDFTCIDMNEKGL 3123 Query: 1328 AGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKI-YSLHGP 1386 A + + NL T+ + +AYVIYTSGSTGKPKGVM+ H+S+ N + YS Sbjct: 3124 AKDMAAE-NLGHTSGSSDMAYVIYTSGSTGKPKGVMVNHQSIVNTLYWRKQSYGYSTADA 3182 Query: 1387 NLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPA 1446 L V F FD+SV+ IF+ + G L ++ D+R + ++ + +K P+ Sbjct: 3183 TLQVP---SFSFDSSVEDIFTTLISGAKLVLIR-DLRMNPREIIGVLRTHKATNLLAVPS 3238 Query: 1447 YLRLLAETSLCARIGVAHFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPTECCVDAT 1506 + L +T + + GE + + +++ + N K + N YGPTE V +T Sbjct: 3239 FYLNLLDTIEQPLDDLRFVTVAGEGFNESLIRQHFEKLPNVK---LFNEYGPTENSVCST 3295 Query: 1507 AFTIKPEETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYCNNKA 1566 ++ ++ +++ IG PI N VYIL+ ++++P G GEL + G G+ARGY N Sbjct: 3296 RGELRKDD----EKVVIGRPISNHKVYILNHNQQLLPLGTPGELCLSGEGLARGYLNRPD 3351 Query: 1567 LTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHRLLS 1626 LT +FV + + PG MY+TGD+ ++ DG I + GR DHQVKIRGFRIEL EI ++LL Sbjct: 3352 LTLEKFVPNPFAPGESMYRTGDLARFLPDGQIEYLGRIDHQVKIRGFRIELGEIENQLLK 3411 Query: 1627 CDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMPVDQIP 1686 +G+ AA V+ ++DQ YLCAY+V + +R L + LPDYM+P + +DQ+P Sbjct: 3412 IEGIDAAAVMAREDQAGGKYLCAYIVADKAAGVADVRKCLLKELPDYMVPSYFVKLDQLP 3471 Query: 1687 MTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFAAGG 1746 +TANGK D LP+P + Y APRNRTEE L ++W +VL + IGI NFF GG Sbjct: 3472 LTANGKIDRKALPEPSSTISEAT-YEAPRNRTEEKLVSIWEDVLGIENIGISHNFFELGG 3530 Query: 1747 DSIKAIQAAARMEKYNLRLEV--KHLFQYQTIGEVSKKVQDRAGHAGYGAVTG--EAGLV 1802 S+KA A++ K +++EV + LF+ TI ++ ++ + Y ++T E Sbjct: 3531 HSLKAAALTAKLHK-EMKIEVPLRQLFETPTIKDIGDFIES-MKESPYASITQAEEKEYY 3588 Query: 1803 PIQS-----WMVEHCRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALRMVFREQ 1857 + S +++ N+ F + F D F ++I H+ALR F Sbjct: 3589 ALSSAQRRLYILNQIEPGGLSYNMPFAMKIAGDFDVDRFEDAFRQLIERHEALRTAFVMV 3648 Query: 1858 NRQMLQHNRGLDGEL-FDFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKGPLVKLALIRA 1916 + + +Q ++ E+ F L P LEK PL++ +++A Sbjct: 3649 DGEPVQK---IEKEVDFKVKYGRLGQDP-----LEEKIKAFIKPFALEKAPLLRAEVLKA 3700 Query: 1917 GYGEHLLIV-IHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLPPKTAPFLQWSNHLHEY 1975 EH+L++ +H +I D +S I + Y E LPP T + +S + Sbjct: 3701 SGDEHVLMLDMHHIISDGVSMAIFTRELAELY------EGKTLPPLTIQYKDFSEWQKLF 3754 Query: 1976 ADSIELLREQPYWDQV--ESIKAEPLPTDYKADEARVRDNLTLYQAFDCTETEQVMSSIR 2033 E+ R++ YW V + LP D K + R + + D ET +++ + Sbjct: 3755 YQKDEVKRQEDYWLNVFQGEVPVLNLPADEKRPQKRSIEGDIVQFEIDG-ETSAMLNKLA 3813 Query: 2034 SNPHFTTESIMLTALALTIRAWTGNAAVVVN---LGNHGRDM 2072 T ++L + +TG +VV G H D+ Sbjct: 3814 KENGATMYMLLLAGYTTLLAKYTGQEDIVVGSPIAGRHHSDL 3855 Score = 527 bits (1357), Expect = e-147, Method: Compositional matrix adjust. Identities = 350/1057 (33%), Positives = 533/1057 (50%), Gaps = 55/1057 (5%) Query: 759 YEVSSSQKRIYILNQLNARSTSYNIPLFVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSF 818 Y +++ Q+ + + S +Y + + M+G +DE +F +++RHE+LR S + Sbjct: 5092 YPLANMQRGMLFHALEDKESQAYFEQMAINMKGLIDERLFAETFNDIMERHEILRASIEY 5151 Query: 819 -VNKELVQAV--DDHVHLAVEKYHADDETDLDQITSQFIRP-----FDLSKAPLIRAGLV 870 + E + D ++L + +Q+ + + F L+ PLIRA L+ Sbjct: 5152 EITDEPRNVIIKDRKINLDYHDLRKQSPAEREQVIQAYRKADREKGFRLNSEPLIRAALM 5211 Query: 871 EIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLY------EHNPLPELNIQFKDFAKWQN 924 + + + HI+ DG S ++ E+ H+Y + + L E + D+ W Sbjct: 5212 RTEDDSYTFIWTNHHILLDGWSRGIIMGELFHMYHMKEARQKHRLEEAR-PYSDYIGWLQ 5270 Query: 925 DLFKTDYMNKQKKYWLDVFSG---ELPILNLPVDYPRDSGQGD-QGERLTCNAGRELTQR 980 K K YW + SG + PI L SG + + +LT R Sbjct: 5271 QQDK----EAAKAYWRNYLSGFTEKSPISVLA----GSSGHAKYKRKEAVIEFPEQLTGR 5322 Query: 981 LNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHK--ELEQMIGMFVNTL 1038 + E +S+ T L + +LL ++ +D++ G+ I+GR + +E+M+G+F+NT+ Sbjct: 5323 ITELASRNNVTFHTVLQCIWGMLLARYNQTDDVVFGTVISGRDAQVTGIEKMVGLFINTV 5382 Query: 1039 ALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNLSGTALFNVMFVLQ 1098 R R FKE + V+E AL+ + D E+ + R L L +F Sbjct: 5383 PTRIRLDKSQSFKELIKSVQEQALEGRTYHDMNLSEVQSLSELKRELLDHIL---IFENY 5439 Query: 1099 VMDNPAFEVNGMHYAPYPYHNKTAK----FDLALQVFPGLDELKFEFTYAAKLFKRSTIE 1154 +D AFE +G A + + A+ + + PG + L + TY ++ I Sbjct: 5440 AVDQSAFETSGKRGAGFVFEEIHAEEQTNYGFNIVAVPG-ERLVIKLTYDGNIYHDHIIA 5498 Query: 1155 SFARRFLRVLEQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAYNTKTIVEMFEAQA 1214 +V+EQVV E + DI VL E R+ Y A Y +TI +FE QA Sbjct: 5499 GIKGHLQQVMEQVVQHEDQSLNDITVLSEAE-RNRLLYEWNDTKAEYPNQTIHRLFEEQA 5557 Query: 1215 ARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERSTNFAVGIMGV 1274 + P+ AV + LTYRELNE++NQLAR L G D +V I+AERS VGIMG+ Sbjct: 5558 EKTPELAAVVSGNDKLTYRELNEKSNQLARYLRDKGVKADTIVAIMAERSPEMVVGIMGI 5617 Query: 1275 LKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLEEVAGN--SG 1332 LK+G AYLPI+P YP ER ++MLEDSGA ++L D H++ L +E E+ G+ S Sbjct: 5618 LKAGGAYLPIDPDYPEERIKYMLEDSGAAIILAD--HKQDLGTLHQEAV--ELTGDFSSY 5673 Query: 1333 EQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKIYSLHGPNLNVAL 1392 NLE +ADSLAY+IYTSGSTGKPKGVMI R + N D ++Y + G L+ AL Sbjct: 5674 PADNLEPAGNADSLAYIIYTSGSTGKPKGVMIRQRGLVNYITWAD-RVY-VQGEQLDFAL 5731 Query: 1393 LAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPAYLRLLA 1452 + FD +V IF+ + G+ + IV + + ++ K I TP++L L+ Sbjct: 5732 YSSIAFDLTVTSIFTPLISGNRV-IVYRHSEDGEPLIRKVFRDQKAGIVKLTPSHLSLVK 5790 Query: 1453 ETSLCARIGVAHFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPTECCVDATAFTIKP 1512 + + I+GGE L K F H I N YGPTE V + Sbjct: 5791 DMDASGS-SIKRLIVGGEDLKTELAKEITERF--HHNIEIYNEYGPTETVVGCMIYQYDA 5847 Query: 1513 EETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYCNNKALTSSRF 1572 Q+ +PIG P N +YILDE++ + P G+ GELYI G GVA+GY N LTS +F Sbjct: 5848 GWDRQVS-VPIGKPASNVQLYILDERQEVQPVGIAGELYISGDGVAKGYLNKPELTSEKF 5906 Query: 1573 VEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHRLLSCDGVQA 1632 + + + PG MY+TGD+ K DG I + GR DHQVKIRG+RIEL EI H+LL ++ Sbjct: 5907 LPNPFLPGERMYRTGDLAKMRPDGHIEYLGRIDHQVKIRGYRIELGEIEHQLLRHSDIKE 5966 Query: 1633 AVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVIMPVDQIPMTANGK 1692 A V + DQ + LCAYVV + ++ +L + LP+YM+P ++ +D++P+T NGK Sbjct: 5967 AAVAAKTDQNNDQVLCAYVVSERDITQKDIKTFLAKELPEYMVPSYLLKLDELPLTPNGK 6026 Query: 1693 ADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFAAGGDSIKAI 1752 D LP+P L Y PR+ EE + +W ++L + +IGI+ N F G +S+ + Sbjct: 6027 VDLKALPEPDRSAGALLEYEPPRHELEEKMAAIWEDILNIEQIGINANIFDIGANSLNVM 6086 Query: 1753 QAAARM-EKYNLRLEVKHLFQYQTIGEVS---KKVQD 1785 +R+ + R+ K +F TI E+S K QD Sbjct: 6087 SFVSRLYAELGFRVPFKDIFSKPTIKELSDFLKHAQD 6123 >emb|CAE02631.1| surfactin synthetase B [Bacillus amyloliquefaciens] Length = 3586 Score = 1045 bits (2702), Expect = 0.0, Method: Compositional matrix adjust. Identities = 590/1564 (37%), Positives = 866/1564 (55%), Gaps = 36/1564 (2%) Query: 666 SKAEISVGQVWGAVLGMNPMSVTADFYEIGGDSIIAIEIVNTLNTIMGLSLQVPVLFEHS 725 ++ E + ++W LG + + + +F++ GG S+ + ++ + + ++ + LFE Sbjct: 2008 TELEEKLCRIWKQTLGTDTLGIDDNFFDYGGHSLKGMMLLANIQAELDKTVPLKALFEQP 2067 Query: 726 NIERLAAYIEGQAGTDKDTRGNSAIPRIAAAEHYEVSSSQKRIYILNQLNARSTSYNIPL 785 + LAAYIE A ++ G I +A+ Y +SS+QKR+Y+LNQL+ + SYN+P Sbjct: 2068 TVRLLAAYIEKSAVSE----GYRMISPADSADAYPLSSAQKRMYVLNQLDRETISYNMPS 2123 Query: 786 FVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSFVNKELVQAVDDHVHLAVEKYHADDETD 845 ++MEG ++ RL+ + +I RHE LRTSF N +Q + + + + + A DE Sbjct: 2124 VLLMEGEVNISRLQEALNQMINRHESLRTSFIDQNGRPMQQIAEQADIDLHIFEAADEEK 2183 Query: 846 LDQITSQFIRPFDLSKAPLIRAGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYE 905 D I FI+PFDLS APLIRA LV + + KHLL+LD+ HIIADG S +L KE+ HLY+ Sbjct: 2184 ADLIIQAFIKPFDLSAAPLIRAALVRLNEKKHLLLLDMHHIIADGVSRSMLVKELAHLYK 2243 Query: 906 HNPLPELNIQFKDFAKWQNDLFKTDYMNKQKKYWLDVFSGELPILNLPVDYPRDSGQGDQ 965 LP N+ +KDFA WQN+ + + M ++YWL FSGELP LNLP D+PR Q + Sbjct: 2244 GGSLPSPNLHYKDFAVWQNEPEQAERMEDHERYWLSAFSGELPELNLPTDFPRPPVQSFK 2303 Query: 966 GERLTCNAGRELTQRLNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHK 1025 G+ + A RE + + E TL M L AAF+V L K TGQ DII+GS AGR Sbjct: 2304 GQSVRFRAVRETEKAVRELMESSGATLHMVLHAAFHVFLSKITGQRDIIIGSVTAGRTSA 2363 Query: 1026 ELEQMIGMFVNTLALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNL 1085 E+++M GMFVNTLALRN F L VK+ L A HQDYPFE+L+ L++ R++ Sbjct: 2364 EVQEMPGMFVNTLALRNETRKEQTFAGLLERVKQTNLDALAHQDYPFEDLIGKLDLPRDM 2423 Query: 1086 SGTALFNVMFVLQVMDNPAFEVNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAA 1145 S LF VM + D E+ + PY + TAKFDL L F + L +F YA Sbjct: 2424 SRNPLFQVMVTTEDPDKETLELENLRITPYESNQGTAKFDLTLGGFTDQEGLGLQFEYAT 2483 Query: 1146 KLFKRSTIESFARRFLRVLEQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAYNTKT 1205 LFK+ TIE ++ FLR+L+Q + +I ++ E + + + + KT Sbjct: 2484 DLFKKETIEKWSAGFLRILKQAAESPDRKLPEISLISDAEKQALLDAWKGKTISVPRDKT 2543 Query: 1206 IVEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERST 1265 + +FE AAR + A + TY ELN +AN++AR+L+ G D VGI+ + S Sbjct: 2544 VHRLFEETAARYANRPAAAYNGAKWTYGELNARANRIARILMDCGVTADERVGILTKPSL 2603 Query: 1266 NFAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRRSLQHGIREICLE 1325 A G++GVLK+GAA++PI+P YP ER ++L+DSGA ++LT A + I L+ Sbjct: 2604 EMAAGVLGVLKAGAAFVPIDPDYPEERISYILQDSGAKLLLTQEALDVPESYNGETILLD 2663 Query: 1326 ------EVAGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEK 1379 + + ++ N + +AD LAY+IYTSG+TG+PKGVM+EH ++ NL Sbjct: 2664 GRRSILSLPLDENDEANPQTETTADHLAYMIYTSGTTGQPKGVMVEHHALVNLC-FWHHD 2722 Query: 1380 IYSLHGPNLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKID 1439 +++ + A A F FDAS+ ++F + +G L+++ +R D+ +L Y+++N + Sbjct: 2723 AFAMTADD-KSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDITRLNHYFEENGVT 2781 Query: 1440 ISDGTPAYLRLLAETSLCARIGVAHFIIGGEALSIAEVKRFYTSFANHKPPYITNVYGPT 1499 I T +L + + ++GG+ L A VK+ YT I N YGPT Sbjct: 2782 I---TFLPTQLAEQFMELENTSLRMLLVGGDKLKRA-VKQPYT---------IINNYGPT 2828 Query: 1500 ECCVDATAFTIKPEETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVAR 1559 E V AT+ I PEE + IG I N VYIL + ++ P G+ GEL + G G+AR Sbjct: 2829 ENTVVATSGVINPEEGS----LSIGRAIANTRVYILGDGDQVQPEGIAGELCVAGRGLAR 2884 Query: 1560 GYCNNKALTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDE 1619 GY N + T+ RF D + PG MY+TGD+ KW I + GR D QVK+RG+RIEL E Sbjct: 2885 GYLNREEETAKRFTADPFVPGERMYRTGDLVKWNAQCGIEYIGRIDQQVKVRGYRIELSE 2944 Query: 1620 IRHRLLSCDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIPRVI 1679 I RL V A V +D+ LCAYV + + + L+ L + LPDYM+P Sbjct: 2945 IEVRLAQLADVHDAAVTAVEDKAGNTALCAYVAPQQDDI-EALKAALKDTLPDYMVPAFW 3003 Query: 1680 MPVDQIPMTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHD 1739 + +D++P+TANGK D LP+P ++ S Y AP E +L +W EVL L +IG+ D Sbjct: 3004 VEMDELPVTANGKIDKKALPEP-DIEAGSAAYKAPETEMETLLSDIWQEVLGLDQIGVSD 3062 Query: 1740 NFFAAGGDSIKAIQAAARMEKYNLRLEVKHLFQYQTIGEVSKKVQDRAG-HAGYGAVTGE 1798 NFF GGDSIK IQ A+R+ ++ +LE+K LFQ+ TI E+ V+ G A G V GE Sbjct: 3063 NFFTLGGDSIKGIQMASRLNQHGYKLEMKDLFQHPTIEELVSYVERTEGKQADQGPVEGE 3122 Query: 1799 AGLVPIQSWMVEHCRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALRMVFREQN 1858 A L PIQ W E H N S +L+ + GF D + K +I HHDALRMV+RE+ Sbjct: 3123 AALTPIQRWFFERNFTDKHHWNQSVMLHAKDGFDPDLVEKTLQALIEHHDALRMVYREER 3182 Query: 1859 RQMLQHNRGLDGELFDFYLIDL--ADSPSFSEEXXXXXXXXXXSMDLEKGPLVKLALIRA 1916 ++Q + F ++DL D + S+DLE GPL+K R Sbjct: 3183 EGIIQTYLPVTECKASFEIVDLYGTDEDMLKSQIQRLADHLQGSLDLENGPLLKAEQYRT 3242 Query: 1917 GYGEHLLIVIHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLPPKTAPFLQWSNHLHEYA 1976 G+HLLI IH +++D +SWRI+LEDF + Y Q I LP KT F W+ L+ +A Sbjct: 3243 EQGDHLLIAIHHLVVDGVSWRILLEDFASGYKQAQQQNSIVLPQKTHSFKDWAEALNTFA 3302 Query: 1977 DSIELLREQPYWDQVESIKAEPLPTDYKADEARVRDNLTLYQAFDCTETEQVMSSIRSNP 2036 S +L ++ YW Q ++ + +PLP D+ ++ V+ + ET Q+++ + Sbjct: 3303 QSEDLKKQAAYWAQADAEELQPLPKDHDPNKRLVKHTAAVKCELTEEETAQLLTDVHHPY 3362 Query: 2037 HFTTESIMLTALALTIRAWTGNAAVVVNLGNHGRDMDSKDIDTYRTVGRFSILYPVALQL 2096 I+L+AL LTI WT N V +NL HGR+ +++ RTVG F+ YP+ LQ+ Sbjct: 3363 GTEINDILLSALGLTIGEWTENGKVGINLEGHGREEIIPNVNISRTVGWFTAQYPLILQI 3422 Query: 2097 PESRNIDLCLEYVKEYLSGIPKQGGGYGVLKYLSSHQEGIRFRLNPELSFNYMGQFDAEF 2156 + + ++ VKE + +P +G GYG+L+YLSS + + PE+SFNY+GQFD E Sbjct: 3423 SKEDGVSSVIKTVKETVRRVPDKGVGYGILRYLSSDE--TEKGVTPEISFNYLGQFDNEV 3480 Query: 2157 NTSTFRISPLSGGEDRSGEEIWSYKLKFISFIRMNQLNIGIEYNQQQYARETVNALLQQY 2216 T F SP G S E Y L F + + I YNQ++Y R TV +Q++ Sbjct: 3481 KTEWFEPSPYDMGRQVSEESEALYALSFSGMVTGGRFVISCSYNQEEYERSTVETQMQRF 3540 Query: 2217 MEYL 2220 + L Sbjct: 3541 KDNL 3544 Score = 799 bits (2064), Expect = 0.0, Method: Compositional matrix adjust. Identities = 527/1609 (32%), Positives = 833/1609 (51%), Gaps = 118/1609 (7%) Query: 666 SKAEISVGQVWGAVLGMNPMSVTADFYEIGGDSIIAIEIVNTLNTIMGLSLQVPVLFEHS 725 ++AE + +W +LG+ VT +F+ IGG S+ A+ + + + + VLFE Sbjct: 968 TEAEQKLADIWEGILGVK-AGVTDNFFTIGGHSLKAMMMTAKIQEHFQKEVPIKVLFEKP 1026 Query: 726 NIERLAAYIEGQAGTDKDTRGNSAIPRIAAAEHYEVSSSQKRIYILNQLNARSTSYNIPL 785 I+ LA Y++ ++ ++ + I + +HY VSS+Q+R+YILNQL STSYN+P Sbjct: 1027 TIQELAHYLQHES---EEEQQFEPIRQAPYQKHYPVSSAQRRMYILNQLGQASTSYNVPA 1083 Query: 786 FVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSFVNKELVQAVDDHVHLAVEKYHADDETD 845 +++EG +D+ RLE + +ALI RHE LRTSF E+VQ + +V +E +E D Sbjct: 1084 VLLLEGSVDKKRLEEAMQALINRHETLRTSFDMAEGEVVQTIHKNVSFELETAEGREE-D 1142 Query: 846 LDQITSQFIRPFDLSKAPLIRAGLVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYE 905 +++T FIRPF L++APL+R+ L+ + +++HLL++D+ HII DGSS+ + ++ LY+ Sbjct: 1143 AEELTKAFIRPFALNRAPLVRSKLIRLEEDRHLLLIDMHHIITDGSSMGIFIGDLAKLYQ 1202 Query: 906 HNPLPELNIQFKDFAKWQNDLFKTDYMNKQKKYWLDVFSGELPILNLPVDYPRDSGQGDQ 965 L I +KDF+ WQ + D + + YWLD F G+LP+L+LP+D+PR + + + Sbjct: 1203 GTELALPKIHYKDFSVWQREKANLD---QHEAYWLDTFKGDLPVLDLPLDFPRPAERSFE 1259 Query: 966 GERLTCNAGRELTQRLNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHK 1025 GER+ +++T ++ + + TT++M LLAAF VLL K++GQEDIIVGSP AGR+H Sbjct: 1260 GERVIFGLDKQVTAQIKKLLADTDTTMYMFLLAAFQVLLSKYSGQEDIIVGSPAAGRQHP 1319 Query: 1026 ELEQMIGMFVNTLALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNL 1085 +L+ + GMFVNT+ALR+ P+ FK+FL VK +LQA+EHQ YP EEL++ L + R+ Sbjct: 1320 DLQDVPGMFVNTVALRSHPAGKKTFKQFLDEVKTASLQAFEHQSYPLEELIEKLPLTRDT 1379 Query: 1086 SGTALFNVMFVLQVMDNPAFEVNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAA 1145 S + LF+V+F +Q M+ PA + + + Y H+ AKFDL+L+ +E+ F YA Sbjct: 1380 SRSPLFSVLFNMQNMEIPALRLGDLEISSYSMHHHVAKFDLSLEAAERGEEVGLSFDYAK 1439 Query: 1146 KLFKRSTIESFARRFLRVLEQVVALEHVLIGDIDVL---DREELRDIRRYGQAGLPAAYN 1202 LF TI ++ F+ +++ + + D +L +RE L + +A LP Sbjct: 1440 ALFADETIRRWSAHFVNLIKACAENPDIQLADASLLSAPEREALLSDEKRTEADLPEG-- 1497 Query: 1203 TKTIVEMFEAQAARIPDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAE 1262 T V +FE QA + PD AV+G SLTYREL+E++N+ AR L G + +V I+ + Sbjct: 1498 --TFVSLFERQAQKTPDLTAVAG-GISLTYRELDERSNRFARHLQACGTGSEDIVAIMMD 1554 Query: 1263 RSTNFAVGIMGVLKSGAAYLPIEPAYPPERKRFMLEDSGA-CMVLTDTAHRRSLQHGIRE 1321 RS + I+GV+K+GAA+LPI+P P ER R+ LEDSG +V+ + + + Sbjct: 1555 RSADLITAILGVMKAGAAFLPIDPETPEERIRYSLEDSGTKLLVVNERNMTAAAVYKGNT 1614 Query: 1322 ICLEEVAGNSGEQGNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKIY 1381 + +E+ + LE D LAY+IYTSG+TGKPKGV +EHR++ N + Sbjct: 1615 VVMEDGEWQNESADRLETEPGFDQLAYIIYTSGTTGKPKGVQLEHRNLINYVTWFSREA- 1673 Query: 1382 SLHGPNLNVALLAPFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDIS 1441 L + +V LL+ + FD IF G L+IVP + QL EY ++N I Sbjct: 1674 GLTEADKSV-LLSSYAFDLGYTAIFPILQAGGELHIVPKETYTAPDQLGEYIQKNGITYM 1732 Query: 1442 DGTPAYLRLLAETSLCA---RIGVAHFII-GGEALSIAEVKRFYTSFANHKPPYITNVYG 1497 TP+ ++ T+ A R ++ GGE + ++V++F+ +A+ N YG Sbjct: 1733 KLTPSLFHMIVNTARFAAERRFSPLRLVVLGGEKIITSDVRKFHDVYAHTD---FINHYG 1789 Query: 1498 PTECCVDATAFTIKPEETGQIQEMP-IGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHG 1556 PTE + A A I E Q ++ P IG PI N +LD ++VP G GELYI G G Sbjct: 1790 PTETTIGAIAGRINMERLDQYEQRPVIGRPIANTGALVLDGAMQLVPPGASGELYIAGKG 1849 Query: 1557 VARGYCNNKALTSSRFVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIE 1616 +ARGY + LT+ +F+ + + P MYKTGD+ + DG I F GRAD QVKIRG+RIE Sbjct: 1850 LARGYLHRPQLTAEKFLSNPFSPDSLMYKTGDVVRRLPDGTIEFIGRADDQVKIRGYRIE 1909 Query: 1617 LDEIRHRLLSCDGVQAAVVLVQKDQRQEPYLCAYVVCRDEQVLPGLRGYLGEYLPDYMIP 1676 L E+ LLS +G+Q AVVL + P LCAY E LR L E LP +M+P Sbjct: 1910 LKEVETVLLSVNGIQEAVVLAVSEGGL-PELCAYYKADSELKGSELRKRLSETLPSHMLP 1968 Query: 1677 RVIMPVDQIPMTANGKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIG 1736 + VD+IP+TANGK D + LP P + P EE LC +W + L +G Sbjct: 1969 AYFVQVDRIPLTANGKTDKNALPKPGVSQTAQTASALPETELEEKLCRIWKQTLGTDTLG 2028 Query: 1737 IHDNFFAAGGDSIKAIQAAARME-KYNLRLEVKHLFQYQTIGEVSKKVQDRAGHAGYGAV 1795 I DNFF GG S+K + A ++ + + + +K LF+ T+ ++ ++ A GY + Sbjct: 2029 IDDNFFDYGGHSLKGMMLLANIQAELDKTVPLKALFEQPTVRLLAAYIEKSAVSEGYRMI 2088 Query: 1796 T--GEAGLVPIQS-----WMVEHC-RDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHH 1847 + A P+ S +++ R+T+ + N+ VL E +++ ++I H Sbjct: 2089 SPADSADAYPLSSAQKRMYVLNQLDRETISY-NMPSVLLMEGEVNISRLQEALNQMINRH 2147 Query: 1848 DALRMVFREQN-RQMLQHNRGLDGELFDFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKG 1906 ++LR F +QN R M Q D D ++ + AD E+ DL Sbjct: 2148 ESLRTSFIDQNGRPMQQIAEQAD---IDLHIFEAAD----EEKADLIIQAFIKPFDLSAA 2200 Query: 1907 PLVKLALIRAGYGEHLLIV-IHQMIIDHLSWRIILEDFNTAY------TQLLNHEDIGLP 1959 PL++ AL+R +HLL++ +H +I D +S +++++ Y + L+++D Sbjct: 2201 PLIRAALVRLNEKKHLLLLDMHHIIADGVSRSMLVKELAHLYKGGSLPSPNLHYKD---- 2256 Query: 1960 PKTAPFLQWSNHLHEYADSIELLREQPYWDQVES--IKAEPLPTD--------YKADEAR 2009 F W N E A+ +E + YW S + LPTD +K R Sbjct: 2257 -----FAVWQNE-PEQAERME--DHERYWLSAFSGELPELNLPTDFPRPPVQSFKGQSVR 2308 Query: 2010 VRDNLTLYQAFDCTETEQVMSSIRSNPHFTTESIMLTALALTIRAWTGNAAVVVNLGNHG 2069 R ETE+ + + + T ++ A + + TG +++ G Sbjct: 2309 FR---------AVRETEKAVRELMESSGATLHMVLHAAFHVFLSKITGQRDIIIGSVTAG 2359 Query: 2070 R------DMDSKDIDT--YRTVGRFSILYPVALQLPESRNIDLCL--EYVKEYLSG---I 2116 R +M ++T R R + L+ + N+D +Y E L G + Sbjct: 2360 RTSAEVQEMPGMFVNTLALRNETRKEQTFAGLLERVKQTNLDALAHQDYPFEDLIGKLDL 2419 Query: 2117 PKQGGGYGVLKYLSSHQEGIRFRLNPELSFNYMGQFDAEFNTSTFRISPLSGGEDRSGEE 2176 P+ + + + + ++ + L E RI+P S + Sbjct: 2420 PRDMSRNPLFQVMVTTEDPDKETLELE----------------NLRITPY-----ESNQG 2458 Query: 2177 IWSYKLKFISFIRMNQLNIGIEYNQQQYARETVNALLQQYMEYLKKAAE 2225 + L F L + EY + +ET+ ++ LK+AAE Sbjct: 2459 TAKFDLTLGGFTDQEGLGLQFEYATDLFKKETIEKWSAGFLRILKQAAE 2507 Score = 483 bits (1243), Expect = e-134, Method: Compositional matrix adjust. Identities = 382/1355 (28%), Positives = 632/1355 (46%), Gaps = 91/1355 (6%) Query: 759 YEVSSSQKRIYILNQLNARSTSYNIPLFVMMEGPLDEGRLEHSFEALIQRHEVLRTSFSF 818 Y ++ Q+ + L+ S+SY L + + G E S LI+ +++LRT F Sbjct: 10 YALTPMQEGMLYHALLDPHSSSYFTQLELRIHGSFQLELFEKSVNELIRTYDILRTVF-- 67 Query: 819 VNKELVQAVDDHVHLAVEKYHADDETDLDQI-TSQFI---------RPFDLSKAPLIRAG 868 V+++L + + K H +D + LD+ +++I + F L+K L +A Sbjct: 68 VHQQLQKPRQVVLAERKTKVHYEDISQLDEARQTEYIERYKRGVQQQGFHLAKDILFKAA 127 Query: 869 LVEIRKNKHLLMLDVQHIIADGSSIPLLQKEIIHLYE--HNPLPELNIQ---FKDFAKWQ 923 + + + + L+ HI+ DG S+ +L K + YE P Q + D+ KW Sbjct: 128 VFRLSEKELYLVWSNHHIVMDGWSMGVLMKSLFQNYEALRAGRPAGGSQGKPYSDYIKW- 186 Query: 924 NDLFKTDYMNKQKKYWLDVFSGELPILNLPVDYP---RDSGQGDQGERLTCNAGRELTQR 980 L DY + ++YW S L P P + Q E + EL + Sbjct: 187 --LGGRDY-EEAEQYW----SSRLADFEQPSLLPGRLASEKKDYQNEEYSFVWDEELVAQ 239 Query: 981 LNEYSSKEKTTLFMTLLAAFNVLLFKHTGQEDIIVGSPIAGRKHK--ELEQMIGMFVNTL 1038 + + +++ + T A + +L K+ +D++ G+ ++GR + +E M G+F+NT+ Sbjct: 240 IQQTANRHQVTGPNLFQAVWGAVLSKYNYTDDVVFGTVVSGRPSEINGIETMAGLFINTI 299 Query: 1039 ALRNRPSAHMVFKEFLAGVKENALQAYEHQDYPFEELVDHLNMDRNL-SGTALFNVMFVL 1097 +R + F + +A V++NA++A + P ++ +D +L + F + Sbjct: 300 PVRIKIDKDAAFSDVMAAVQKNAVEAERYDYVPLYDIQKRSALDGSLLNHLVAFENYPLD 359 Query: 1098 QVMDNPAFEVNGMHYAPYPYHNKTAKFDLALQVFPGLDELKFEFTYAAKLFKRSTIESFA 1157 + ++N E + + FD L V+PG + Y F IE A Sbjct: 360 KELENGGMEERLGFSIKVEHAFEQTSFDFNLIVYPG-KTWTVKIKYNGAAFAHDAIERTA 418 Query: 1158 RRFLRVLEQVVALEHVLIGDIDVLDREELRDIRRYGQAGLPAAYNTKTIVEMFEAQAARI 1217 R+++ V + ++ ++ EE R I A + + +FEAQA R Sbjct: 419 HHLTRMMKAAVGTPDAPVRELGLVSGEEERQIVEVFNDTKTALPEEEAVHRLFEAQANRT 478 Query: 1218 PDHLAVSGFDRSLTYRELNEQANQLARVLIRNGACKDRVVGIIAERSTNFAVGIMGVLKS 1277 P +A+ R TYRE+NE AN+LAR L+++G K R I+ +RS VG++ VLK+ Sbjct: 479 PASIAIKEAGREWTYREVNEAANRLARHLVKSGLEKGRTAAIMNDRSAETVVGMLAVLKA 538 Query: 1278 GAAYLPIEPAYPPERKRFMLEDSGACMVLTDTAHRR---SLQHGIREICLEEVAGNSGEQ 1334 G AY+PI+PA+P +R RFM EDS +VLT ++ +LQ + + L+E A + Sbjct: 539 GGAYVPIDPAFPEDRLRFMAEDSSIRLVLTVQDYQEQAGALQVPV--VMLDESADETVSG 596 Query: 1335 GNLEATASADSLAYVIYTSGSTGKPKGVMIEHRSVTNLAEALDEKIYSLHGPNLNVALLA 1394 +L A + LAY++YTSGSTGKPKGVMIEHR++ L + +H + +A Sbjct: 597 TDLNLPAGGNDLAYIMYTSGSTGKPKGVMIEHRNIIRLVK--HSNYVPVHEED-RMAQTG 653 Query: 1395 PFVFDASVKQIFSAFLLGHHLNIVPGDVRQDVIQLAEYYKQNKIDISDGTPAYLRLLAET 1454 FDA ++F A L G L+ V + D Q A++ K+ +I T LA+ Sbjct: 654 AVSFDAGTFEVFGALLNGASLHPVKKETLLDAGQFAQFLKEQRITTMWLTSPLFNQLAQK 713 Query: 1455 SLCARIGVAHFIIGGEALS---IAEVKRFYTSFANHKPPYITNVYGPTECCVDATAFTIK 1511 + H IIGG+AL +++V++ + + N YGPTE +T+F I Sbjct: 714 DAGMFNTLRHLIIGGDALVPHIVSKVRKASPELS------LWNGYGPTENTTFSTSFLID 767 Query: 1512 PEETGQIQEMPIGAPIKNCSVYILDEQKRMVPRGVLGELYIGGHGVARGYCNNKALTSSR 1571 + G + PIG PI N + YI+DE + + P G GEL +GG GVARGY N LT + Sbjct: 768 QDYDGSV---PIGKPIGNSTAYIMDENRNLQPIGAPGELCVGGSGVARGYVNLPELTEKQ 824 Query: 1572 FVEDIYHPGMYMYKTGDMGKWTEDGLIHFAGRADHQVKIRGFRIELDEIRHRLLSCDGVQ 1631 FV D + P +Y+TGD+ KW DG I F GR D+QVK+RGFRIEL EI ++ + V Sbjct: 825 FVRDPFRPDEMIYRTGDLAKWLPDGTIEFLGRIDNQVKVRGFRIELGEIEAKISQAENVT 884 Query: 1632 AAVVLVQKDQRQEPYLCAYVVCRDEQVLP-GLRGYLGEYLPDYMIPRVIMPVDQIPMTAN 1690 + +++K++ E +CAY D+ + P LR L E LP+YMIP + ++Q P+TAN Sbjct: 885 ESAAVIRKNKADENEICAYFTA-DQALSPEDLRKTLSESLPEYMIPAHFIQMNQFPLTAN 943 Query: 1691 GKADTSQLPDPQEMRDHSLGYGAPRNRTEEILCTVWSEVLELRRIGIHDNFFAAGGDSIK 1750 GK D LP+PQ Y AP+ E+ L +W +L + + G+ DNFF GG S+K Sbjct: 944 GKIDKKALPEPQAEAVQK-EYVAPKTEAEQKLADIWEGILGV-KAGVTDNFFTIGGHSLK 1001 Query: 1751 AIQAAARM-EKYNLRLEVKHLFQYQTIGEVSKKVQDRAGHAGYGAVTGEAGL---VPIQS 1806 A+ A++ E + + +K LF+ TI E++ +Q + +A P+ S Sbjct: 1002 AMMMTAKIQEHFQKEVPIKVLFEKPTIQELAHYLQHESEEEQQFEPIRQAPYQKHYPVSS 1061 Query: 1807 -----WMVEHCRDTLQHRNLSFVLYREAGFGEDNIRKVFTEIIRHHDALRMVFREQNRQM 1861 +++ N+ VL E + + + +I H+ LR F ++ Sbjct: 1062 AQRRMYILNQLGQASTSYNVPAVLLLEGSVDKKRLEEAMQALINRHETLRTSFDMAEGEV 1121 Query: 1862 LQHNRGLDGELFDFYLIDLADSPSFSEEXXXXXXXXXXSMDLEKGPLVKLALIRAGYGEH 1921 +Q + +L + E+ L + PLV+ LIR H Sbjct: 1122 VQ-------TIHKNVSFELETAEGREEDAEELTKAFIRPFALNRAPLVRSKLIRLEEDRH 1174 Query: 1922 LLIV-IHQMIIDHLSWRIILEDFNTAYTQLLNHEDIGLPP-KTAPFLQWSNHLHEYADSI 1979 LL++ +H +I D S I + D +L ++ LP F W + Sbjct: 1175 LLLIDMHHIITDGSSMGIFIGDL----AKLYQGTELALPKIHYKDFSVWQR------EKA 1224 Query: 1980 ELLREQPYWDQVESIKAE----PLPTDYKADEARVRDNLTLYQAFDCTETEQVMSSIRSN 2035 L + + YW +++ K + LP D+ R + + D T Q+ + ++ Sbjct: 1225 NLDQHEAYW--LDTFKGDLPVLDLPLDFPRPAERSFEGERVIFGLDKQVTAQI-KKLLAD 1281 Query: 2036 PHFTTESIMLTALALTIRAWTGNAAVVVNLGNHGR 2070 T +L A + + ++G ++V GR Sbjct: 1282 TDTTMYMFLLAAFQVLLSKYSGQEDIIVGSPAAGR 1316 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.319 0.136 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 3,336,134,953 Number of extensions: 146131406 Number of successful extensions: 364985 Number of sequences better than 1.0e-05: 4180 Number of HSP's gapped: 345033 Number of HSP's successfully gapped: 5796 Length of query: 2232 Length of database: 757,237,578 Length adjustment: 142 Effective length of query: 2090 Effective length of database: 371,693,520 Effective search space: 776839456800 Effective search space used: 776839456800 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 134 (56.2 bits)