BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0377.0019.p (365 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_241655.1| BH0789~unknown conserved protein in others (div... 266 6e-70 ref|NP_269660.1| conserved hypothetical protein [Streptococcus p... 254 2e-66 ref|NP_562331.1| conserved hypothetical protein [Clostridium per... 254 3e-66 ref|NP_607667.1| conserved hypothetical protein [Streptococcus p... 252 1e-65 ref|NP_665101.1| putative sugar hydrolase [Streptococcus pyogene... 243 5e-63 >ref|NP_241655.1| BH0789~unknown conserved protein in others (divided) [Bacillus halodurans] pir||E83748 hypothetical protein BH0789 [imported] - Bacillus halodurans (strain C-125) dbj|BAB04508.1| BH0789~unknown conserved protein in others (divided) [Bacillus halodurans] Length = 777 Score = 266 bits (680), Expect = 6e-70, Method: Compositional matrix adjust. Identities = 143/356 (40%), Positives = 202/356 (56%), Gaps = 8/356 (2%) Query: 1 VTDKRTGRVYEAQGIYEDYGDIGNEYVFRQPEGDVPLTTRGVPARISLVEHEAYRITYEI 60 + DK TG Y GIYED GDIGNEY+F+ V TT A I ++E+ + T EI Sbjct: 425 ILDKTTGFEYRHLGIYEDVGDIGNEYMFKASSDGVRYTTEACEASIRIIENNSLCATVEI 484 Query: 61 VHEWEIPASAEASFEEEKRKMVPFRQRKAGRSSEQAPLRIVTRVSLEAGGQGVQVTAAFN 120 +PA+A+ +EE+ ++V RKAGRS E+ + + T ++LE G +G++V + Sbjct: 485 CQTLSVPAAADERLKEEQERLVWHPDRKAGRSKERTDITLRTELTLEQGAKGLKVNVNID 544 Query: 121 NQAKDHRLRVLFPTGLAAATHLVDSVFEAAERDINPAPDWINPSNAQHQQAFVSVSDGMT 180 N AKDHR+R LFP A H DS++E ER P P W NP+ H Q VS+ +G Sbjct: 545 NTAKDHRMRALFPVERARGNHYADSIYEIVERPNTPDPKWQNPAFDHHMQRLVSLDNGEY 604 Query: 181 GFTVANKGLNEYEVLRDGKNTIAITLLRSVSELGDWGVFPTPEAQCLGEHTVEFALCPHA 240 G T+A KGL+EYE++ D +IA+TLLRSV ELGDWG+F TPEAQC G++ +F L PH Sbjct: 605 GLTIATKGLHEYEIVSD---SIAVTLLRSVGELGDWGLFETPEAQCFGQNEAQFVLLPHK 661 Query: 241 GDAVQSEAFAWAYQYQTPWFAVQTGWQQGSLPAVYQPLEWQGRTLALSAFKMSAAHEDII 300 GD + + + AY +QT G LP +W G L L+A K + +I Sbjct: 662 GDVLSANVYVAAYDDPVEPTVIQTEQSMGPLPHATNLFQWSGEGLVLTACKPTMDGRGMI 721 Query: 301 LRWYNLAHKEQEFTLKA-HFPVEAVYASDILERRKPPEQLEEGMLRKAVGPAQIVT 355 LRW+N + + +++ HF +Y S ILE + E+L ++ V P +IVT Sbjct: 722 LRWFNPKREGEALIVQSTHFL--QIYRSTILEEQ--IEKLGTENVQIEVRPQEIVT 773 >ref|NP_269660.1| conserved hypothetical protein [Streptococcus pyogenes] gb|AAK34381.1| conserved hypothetical protein [Streptococcus pyogenes M1 GAS] Length = 901 Score = 254 bits (649), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 147/362 (40%), Positives = 206/362 (56%), Gaps = 18/362 (4%) Query: 1 VTDKRTGRVYEAQGIYEDYGDIGNEYVFRQPEGDVPLTTRGVPARISLVEHEAYRITYEI 60 +TDK++G +Y+ +ED GDIGNEY+ RQP D P +++++ + A EI Sbjct: 549 ITDKQSGLIYQDLLRFEDCGDIGNEYISRQPNHDQPFYADQGTIKLNIISNTAQVAELEI 608 Query: 61 VHEWEIPASAEASFEEEKRKMVPFRQRKAGRSSEQAPLRIVTRVSLEAGGQGVQVTAAFN 120 + IP SA+ + E ++ +R+A RS E+A L + T + +E +Q T F+ Sbjct: 609 QQTFAIPISADKLLQAEMEAVIDITERQARRSQEKAELTLTTLIRMEKNNPRLQFTTRFD 668 Query: 121 NQAKDHRLRVLFPTGLAAATHLVDSVFEAAERDINP-APDWINPSNAQHQQAFVSVSDGM 179 NQ +HRLRVLFPT L HL DS+FE +R +P A W NPSN QHQ+ FVS+ DG Sbjct: 669 NQMTNHRLRVLFPTHLKTDHHLADSIFETVKRPNHPDATFWKNPSNPQHQECFVSLFDGE 728 Query: 180 TGFTVANKGLNEYEVLRDGKNTIAITLLRSVSELGDWGVFPTPEAQCLGEHTVEFALCPH 239 G T+ N GLNEYE+L D NTIAITLLRSV E+GDWG FPTPEAQCLG+H++ ++ Sbjct: 729 NGVTIGNYGLNEYEILPD-TNTIAITLLRSVGEMGDWGYFPTPEAQCLGKHSLSYSF-ES 786 Query: 240 AGDAVQSEAFAWAYQYQTPWFAVQTGWQQGSLPAVYQPLEWQGRTLALSAFKMSAAHEDI 299 Q ++ A + Q P QT +G+L A Y L +AL+AFK A + Sbjct: 787 ITKQTQFASYWRAQEGQVPVITTQTNQHEGTLAAEYSYLTGTNDQVALTAFKRRLADNAL 846 Query: 300 ILRWYNLAH-KEQEFTLKAHFPVEAVYASDILE---RRKPPEQLEEGMLRKAVGPAQIVT 355 I R YNL++ K +F+L P +++LE ++ P QL G A+I+T Sbjct: 847 ITRSYNLSNDKTCDFSLS--LPNYNAKVTNLLEKDSKQSTPSQL---------GKAEILT 895 Query: 356 CA 357 A Sbjct: 896 LA 897 >ref|NP_562331.1| conserved hypothetical protein [Clostridium perfringens] dbj|BAB81121.1| conserved hypothetical protein [Clostridium perfringens str. 13] Length = 859 Score = 254 bits (648), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 132/353 (37%), Positives = 199/353 (56%), Gaps = 21/353 (5%) Query: 4 KRTGRVYEAQGIYEDYGDIGNEYVFRQPEGDVPLTTRGVPARISLVEHEAYRITYEIVHE 63 K T + Y+ +ED GDIG+EY+FR PE D+ + T G A I++++ E+ + Sbjct: 522 KGTNKEYKNLNAFEDCGDIGDEYIFRAPEKDLVVNTLGNKASINVLKDNEVEKVIEVKNT 581 Query: 64 WEIPASAEASFEEEKRKMVPFRQRKAGRSSEQAPLRIVTRVSLEAGGQGVQVTAAFNNQA 123 E+P A ++++ R E +++V+ + L + V + N A Sbjct: 582 LEVPVKA--------------IKKESRRVEETTEIKLVSTIILSEVSKRVDIKVEIENTA 627 Query: 124 KDHRLRVLFPTGLAAATHLVDSVFEAAERDINPAPDWINPSNAQHQQAFVSVSDGMTGFT 183 KDHR+R LFPTG+ A+TH + F+ ER+ P W NPSN Q Q FV V+DG G Sbjct: 628 KDHRVRALFPTGIEASTHFAEGHFDVIERETTPWEGWQNPSNCQKQTNFVDVNDGKVGLM 687 Query: 184 VANKGLNEYEVLRDGKNTIAITLLRSVSELGDWGVFPTPEAQCLGEHTVEFALCPHAGDA 243 VAN GL EYEVLRDG+NTIA+T+LRSV ELGDWGVF TPEAQCLG++ E+++ H GD Sbjct: 688 VANMGLPEYEVLRDGENTIALTILRSVGELGDWGVFKTPEAQCLGKNVAEYSIIAHEGDY 747 Query: 244 VQSEAFAWAYQYQTPWFAVQTGWQ-QGSLPAVYQPLEWQGRTLALSAFKMSAAHEDIILR 302 A+ AY TP A+Q ++ + SL ++ +G + LSAFK + + II+R Sbjct: 748 TGERAYEEAYNLNTPMLALQGDFKDEDSLVSI------KGENVVLSAFKKAEDGDSIIVR 801 Query: 303 WYNLAHKEQEFTLKAHFPVEAVYASDILERRKPPEQLEEGMLRKAVGPAQIVT 355 +N++ KE+ F +K + V+ + ++ E +++E + + QI T Sbjct: 802 IFNISDKEENFQIKVNRDVKEINEVNLNEELIEKLEVKENAINGIISKKQIKT 854 >ref|NP_607667.1| conserved hypothetical protein [Streptococcus pyogenes MGAS8232] gb|AAL98166.1| conserved hypothetical protein [Streptococcus pyogenes MGAS8232] Length = 901 Score = 252 bits (643), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 146/362 (40%), Positives = 206/362 (56%), Gaps = 18/362 (4%) Query: 1 VTDKRTGRVYEAQGIYEDYGDIGNEYVFRQPEGDVPLTTRGVPARISLVEHEAYRITYEI 60 +TDK++G +Y+ +ED GDIGNEY+ RQP D P +++++ + A EI Sbjct: 549 ITDKQSGLIYQDLLRFEDCGDIGNEYISRQPNHDQPFYADQGTTKLNIISNTAQVAELEI 608 Query: 61 VHEWEIPASAEASFEEEKRKMVPFRQRKAGRSSEQAPLRIVTRVSLEAGGQGVQVTAAFN 120 + IP SA+ + E ++ +R++GRS E+A L + T + +E +Q T F+ Sbjct: 609 QQTFAIPVSADKLLQAEMEAVIDITERQSGRSQEKAELTLTTLIRMEKNNPRLQFTTRFD 668 Query: 121 NQAKDHRLRVLFPTGLAAATHLVDSVFEAAERDINP-APDWINPSNAQHQQAFVSVSDGM 179 NQ +HRLRVLFPT L HL DS+FE +R +P A W NPSN QHQ+ FVS+ DG Sbjct: 669 NQMTNHRLRVLFPTHLKTDHHLADSIFETVKRPNHPNAAFWKNPSNPQHQECFVSLFDGE 728 Query: 180 TGFTVANKGLNEYEVLRDGKNTIAITLLRSVSELGDWGVFPTPEAQCLGEHTVEFALCPH 239 G T+ N GLNEYE+L D NTIAITLLRSV E+GDWG FPTPEAQCLG+H++ ++ Sbjct: 729 KGVTIGNYGLNEYEILPDS-NTIAITLLRSVGEMGDWGYFPTPEAQCLGQHSLSYSF-ES 786 Query: 240 AGDAVQSEAFAWAYQYQTPWFAVQTGWQQGSLPAVYQPLEWQGRTLALSAFKMSAAHEDI 299 Q ++ A + Q P QT GSL A + + +AL+AFK A + Sbjct: 787 IDRQTQFASYWRAQEGQVPILVEQTSHHTGSLRAEHSYVTGADDQVALTAFKRRLADNAL 846 Query: 300 ILRWYNLAH-KEQEFTLKAHFPVEAVYASDILE---RRKPPEQLEEGMLRKAVGPAQIVT 355 I R YNL++ K +F+L P +++LE ++ P QL G A+I+T Sbjct: 847 ITRSYNLSNDKTCDFSLS--LPNYNAKVTNLLEKDSKQSTPSQL---------GKAEILT 895 Query: 356 CA 357 A Sbjct: 896 LA 897 >ref|NP_665101.1| putative sugar hydrolase [Streptococcus pyogenes MGAS315] ref|NP_801826.1| conserved hypothetical protein [Streptococcus pyogenes SSI-1] gb|AAM79904.1| putative sugar hydrolase [Streptococcus pyogenes MGAS315] dbj|BAC63659.1| conserved hypothetical protein [Streptococcus pyogenes SSI-1] Length = 901 Score = 243 bits (620), Expect = 5e-63, Method: Compositional matrix adjust. Identities = 144/362 (39%), Positives = 204/362 (56%), Gaps = 18/362 (4%) Query: 1 VTDKRTGRVYEAQGIYEDYGDIGNEYVFRQPEGDVPLTTRGVPARISLVEHEAYRITYEI 60 +TDK++G Y+ +ED GDIGNEY+ RQP D P +++++ + A EI Sbjct: 549 ITDKQSGVSYQDLLRFEDCGDIGNEYISRQPTHDQPFYADQGTTKLNIISNTAQVAELEI 608 Query: 61 VHEWEIPASAEASFEEEKRKMVPFRQRKAGRSSEQAPLRIVTRVSLEAGGQGVQVTAAFN 120 + IP SA+ + E ++ +R+A RS E+A L + T + +E +Q T F+ Sbjct: 609 QQTFAIPISADKLLQAEMEAVIDITERQARRSQEKAELTLTTLIRMEKNNPRLQFTTRFD 668 Query: 121 NQAKDHRLRVLFPTGLAAATHLVDSVFEAAERDIN-PAPDWINPSNAQHQQAFVSVSDGM 179 NQ +HRLRVLFPT L HL DS+FE +R + A W NPSN QHQ+ FVS+ DG Sbjct: 669 NQMTNHRLRVLFPTHLKTDHHLADSIFETVKRPNHLDATFWKNPSNPQHQECFVSLFDGE 728 Query: 180 TGFTVANKGLNEYEVLRDGKNTIAITLLRSVSELGDWGVFPTPEAQCLGEHTVEFALCPH 239 G T+ N GLNEYE+L D NTIAITLLRSV E+GDWG FPTPEAQCLG+H++ ++ Sbjct: 729 KGVTIGNYGLNEYEILPD-TNTIAITLLRSVGEMGDWGYFPTPEAQCLGKHSLSYSF-ES 786 Query: 240 AGDAVQSEAFAWAYQYQTPWFAVQTGWQQGSLPAVYQPLEWQGRTLALSAFKMSAAHEDI 299 Q ++ A + Q P QT +GSL A + + +AL+AFK + + Sbjct: 787 ITKQTQFASYWRAQEGQVPILVEQTSHHKGSLRAEHSYVTGADDQVALTAFKRRPSDNAL 846 Query: 300 ILRWYNLAH-KEQEFTLKAHFPVEAVYASDILE---RRKPPEQLEEGMLRKAVGPAQIVT 355 I R YNL++ K +F+L P +++LE ++ P QL G A+I+T Sbjct: 847 ITRSYNLSNDKTCDFSLS--LPNYNAKVTNLLEKDSKQSTPSQL---------GKAEILT 895 Query: 356 CA 357 A Sbjct: 896 LA 897 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.317 0.133 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 548,933,081 Number of extensions: 22216273 Number of successful extensions: 47496 Number of sequences better than 1.0e-05: 24 Number of HSP's gapped: 47458 Number of HSP's successfully gapped: 24 Length of query: 365 Length of database: 757,237,578 Length adjustment: 127 Effective length of query: 238 Effective length of database: 412,420,005 Effective search space: 98155961190 Effective search space used: 98155961190 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 126 (53.1 bits)