BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0377.0012.p (773 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_953363.1| sensory box histidine kinase/response regulator... 350 8e-95 ref|ZP_00079411.1| COG2202: FOG: PAS/PAC domain [Geobacter metal... 333 8e-90 ref|ZP_00060561.1| COG2202: FOG: PAS/PAC domain [Clostridium the... 325 2e-87 ref|ZP_00097625.1| COG2202: FOG: PAS/PAC domain [Desulfitobacter... 317 8e-85 ref|NP_951775.1| sensory box histidine kinase/response regulator... 304 5e-81 >ref|NP_953363.1| sensory box histidine kinase/response regulator [Geobacter sulfurreducens PCA] gb|AAR35690.1| sensory box histidine kinase/response regulator [Geobacter sulfurreducens PCA] Length = 982 Score = 350 bits (898), Expect = 8e-95, Method: Compositional matrix adjust. Identities = 228/606 (37%), Positives = 333/606 (54%), Gaps = 26/606 (4%) Query: 187 SEVLGYDSEQLVGRDIRGLI-HPDDLAAL--HFPEAQDFQRVQIRVLHTDGRYLWIEFTL 243 +++ GY E+L G ++ L+ HPDD+ ++ A + Q+R + DG +E Sbjct: 247 AKLFGYPREELEGINVISLLFHPDDIGSMIDKMSRAHS-EPYQVRGVKKDGTVFDVEIEG 305 Query: 244 RLIAEGTQYSVLAVGRDITERKIVEQKLQESVERYTSLKKYNHDAIISLDLE---GRIIN 300 + G + + RDITER+ E+ L++S + +L + H A + L ++ G I++ Sbjct: 306 YNLQHGDKSVRVVSVRDITERRRAEEALRQSEALFRNL--FEHHAAVKLIIDPVSGAIVD 363 Query: 301 GNEKACQLTGYSIPELAGMNVGRI--IGAEHLGEVIAYSKEGSPAEVNIDHIWHREGYSV 358 N A G+S +L MN+ I + E L + +K H R SV Sbjct: 364 ANNAAVSFYGWSREQLRAMNIRDINMLSPEELVSELENTKNMERIHFFFRH--RRADDSV 421 Query: 359 EVLTTIAPIIINQETVGLYIIAKDITDQXXXXX----XXXXXXXTNRAKSEFLAMMSHEI 414 + + I + L+ I D+T++ NRAKSEFLA MSHEI Sbjct: 422 RDVEVFSSRIEVKGREYLHSIVHDVTERKRAEEELLLAKEQAESANRAKSEFLANMSHEI 481 Query: 415 RTPMNGVIGMTDLLLEMSEPGSLQREYLDIIRQSGDTLLAIINDVLDFSKIEAGKTILHE 474 RTPMNGVIGMT LLLE QR Y +I+R S +LL +I+D+LDFSKIEAG+ + Sbjct: 482 RTPMNGVIGMTGLLLETGLADE-QRRYAEIVRTSAASLLQVIDDILDFSKIEAGRLEMET 540 Query: 475 EPFMLMPCVDSVLELLQHKADKKGLKIEVSIGPDVPEHLIGDGERLKQILLNLVGNAVKF 534 F L +D + E L KA++KGL + P+VP L+GD RLKQ+L+NL GNA+KF Sbjct: 541 IGFDLRTLLDDLAESLAFKANEKGLTFTCLLRPEVPRFLMGDPVRLKQVLVNLAGNALKF 600 Query: 535 TYTGGIKVTLRVLARAGGSVTLEFTVADTGIGIPESSRSRLFEPFYQLDHFIDRRHEGTG 594 T+ G I V + L + G SV L F V DTGIGIP LFE F Q D I R++ GTG Sbjct: 601 THQGEISVEVGSLTKTGDSVKLRFAVRDTGIGIPPEKTELLFEKFTQADASITRKYGGTG 660 Query: 595 LGLAITRQLVEMMGGSIALDTTVETGASFVFTV-----KLREESGSLPDSASGTEGDEAL 649 LGLAI ++LV+MMGG I + + G+ F FT LR+ S PD G + Sbjct: 661 LGLAICKRLVQMMGGEIGVTSRPGVGSEFWFTASFGTQNLRDSSPE-PDGGDGPLQLLSD 719 Query: 650 SGERSLRILVAEDNEINQIVLRKILEKRGYSVDVAGDGLQVMEMAREQSYDLIFMDVQMP 709 G +RIL+ EDN N+ V I+++ G D A +G + +++ YDL+ MDVQMP Sbjct: 720 LGHDDVRILLVEDNATNRQVALGIIKRLGLRGDAAANGAEALDLLATTPYDLVLMDVQMP 779 Query: 710 RMNGLEATQAIKETLPP--DKQPVIIAVTANALKGDRELCLAAGMDEYISKPLRSEAITN 767 M+G EAT+ I++ P + + +IA+TA+A+KGDR CL AGM++Y++KP+ +A+ Sbjct: 780 VMDGFEATRHIRDVRSPVLNHEIPVIALTAHAMKGDRRKCLDAGMNDYLAKPIFPDALAE 839 Query: 768 IVGKFF 773 ++ K+ Sbjct: 840 MLVKWL 845 >ref|ZP_00079411.1| COG2202: FOG: PAS/PAC domain [Geobacter metallireducens] Length = 1313 Score = 333 bits (855), Expect = 8e-90, Method: Compositional matrix adjust. Identities = 218/651 (33%), Positives = 343/651 (52%), Gaps = 55/651 (8%) Query: 160 RQIVANISDVVYYATSDNICRYCSPSVSEVLGYDSEQLVGRDIRGLIHPDDLAALHFPEA 219 R I + D + Y +P+ ++LGY + + +G+++ L+ P+ A H Sbjct: 562 RSITNSAHDAILMMDHQGSISYWNPAAEQILGYSAAEALGKNLHDLLTPERYLADHLTAF 621 Query: 220 QDFQR----------VQIRVLHTDGRYLWIEFTLRLIAEGTQYSVLAVGRDITERKIVEQ 269 +FQ+ +++ DG+ + + +L + ++ + + RDITE+K Sbjct: 622 SEFQQTGSGNAVGKTLELFARRKDGQEIEVALSLSAVFLNGAWNAVGLLRDITEQK---- 677 Query: 270 KLQESVERYTSLKKYNHDAIISLDLEGRIINGNEKACQLTGYSIPELAGMNVGRIIGAEH 329 ++ S+ ++ +++ +II D +GRI N K+CQ+TGY+ EL G N + G H Sbjct: 678 RINASLRMLSAAVEHSPVSIIITDRDGRIEYVNPKSCQMTGYAFEELRGQNPRIMKGPTH 737 Query: 330 -------LGEVIAYSKEGSPAEVNIDHIWHREGYSVEVLTTIAPIIINQETVGLYI-IAK 381 L E I +E H ++G V V+ +I+PI + + ++ + + Sbjct: 738 PPEFYKNLWETILSGREW----YGEFHNRRKDGSLVWVMASISPIYDEKGEITHFVGVRE 793 Query: 382 DITDQXX-----------XXXXXXXXXXTNRAKSEFLAMMSHEIRTPMNGVIGMTDLLLE 430 +I Q NRAKSEFLA MSHEIRTP+N +IGM+DLL E Sbjct: 794 EIEKQKKLQEELANIAQLEKVARDRAEQANRAKSEFLAGMSHEIRTPLNAIIGMSDLLAE 853 Query: 431 MSEPGSLQREYLDIIRQSGDTLLAIINDVLDFSKIEAGKTILHEEPFMLMPCVDSVLELL 490 G Q YL ++ +G+TL +IND+LD SKIEAG L PF L C+ + ++ Sbjct: 854 TRLDGE-QSGYLSVVHSAGETLQGLINDILDLSKIEAGMLQLDSVPFSLRDCIRQLTDIT 912 Query: 491 QHKADKKGLKIEVSIGPDVPEHLIGDGERLKQILLNLVGNAVKFTYTGG-IKVTLRVLAR 549 KA KG+ S+ VP+ L+GD RL+Q+L+NLVGNAVKFT +GG + + + + + Sbjct: 913 SVKASSKGVTYSFSVKSAVPDWLMGDSLRLRQVLINLVGNAVKFTDSGGSVLLEVEPVQQ 972 Query: 550 AGGSVTLEFTVADTGIGIPESSRSRLFEPFYQLDHFIDRRHEGTGLGLAITRQLVEMMGG 609 + V + F+VADTGIGI +FE F Q D RR+ GTGLGLAI+R L MMGG Sbjct: 973 SDAEVLIRFSVADTGIGIAPEKLDTIFESFSQADSSTTRRYGGTGLGLAISRHLAGMMGG 1032 Query: 610 SIALDTTVETGASFVFTVKL---REESGSLPDSASGTEGDEALSGE---RSLRILVAEDN 663 I +++TV G+ F FTV R LP E L G+ R L ILV +DN Sbjct: 1033 EIGVESTVGKGSCFRFTVPFAISRRTEEPLP--------KEQLPGDKLGRPLSILVVDDN 1084 Query: 664 EINQIVLRKILEKRGYSVDVAGDGLQVMEMAREQSYDLIFMDVQMPRMNGLEATQAIKET 723 N+ VL + ++V+ A +G + + + YD++FMD++MP M+G A + ++E Sbjct: 1085 LANRTVLTAYFRRTEHTVECAVNGEEALAKIKGGGYDVVFMDMEMPVMDGYTAVRLVREW 1144 Query: 724 -LPPDKQPV-IIAVTANALKGDRELCLAAGMDEYISKPLRSEAITNIVGKF 772 + P+ +IA+TANALK D+ L AG +++KP++ + + IVG++ Sbjct: 1145 ERETGRAPLPVIALTANALKEDQLRSLDAGCTAHLTKPIKKDKLLEIVGEY 1195 >ref|ZP_00060561.1| COG2202: FOG: PAS/PAC domain [Clostridium thermocellum ATCC 27405] Length = 902 Score = 325 bits (834), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 204/532 (38%), Positives = 307/532 (57%), Gaps = 37/532 (6%) Query: 254 VLAVGRDITERKIVEQKLQ---ESVERYTSLKKYNHDAIISLDLEGRIINGNEKACQLTG 310 V+ V RDIT + E+KLQ ++VE+ + I+ D G I N + ++TG Sbjct: 262 VVVVFRDITRIRKAEEKLQKLSQAVEQSPGI-------IVMADTRGNIEYVNPRFTEVTG 314 Query: 311 YSIPELAGMNVGRI----IGAEHLGEVIAYSKEGSPAEVNIDH-------IWHREGYSVE 359 YS E+ G ++ + G E ++I G I H W YS Sbjct: 315 YSFDEVKGKSLFFMELEENGEEKCKDMIQAVFSGKEWRSEIRHKSKNNVVFWEYAYYS-- 372 Query: 360 VLTTIAPIIINQETVGLYI-IAKDITDQXXXXXX----XXXXXXTNRAKSEFLAMMSHEI 414 PII ++ V Y+ +++DIT++ NRAKSEFLA MSHEI Sbjct: 373 ------PIINSEGVVTNYLKVSEDITERKLMSENLFKAKEAAEAANRAKSEFLANMSHEI 426 Query: 415 RTPMNGVIGMTDLLLEMSEPGSLQREYLDIIRQSGDTLLAIINDVLDFSKIEAGKTILHE 474 RTP+NG+IGMT+L L+ +E QRE L+I+ + LL +IND+LD+SKIEAGK L Sbjct: 427 RTPLNGIIGMTNLTLQ-TELTDEQRENLNIVNSCAELLLRVINDILDYSKIEAGKMTLEN 485 Query: 475 EPFMLMPCVDSVLELLQHKADKKGLKIEVSIGPDVPEHLIGDGERLKQILLNLVGNAVKF 534 F ++ + +A++KGL++ ++ +P L+GD RL+Q+L NL+ NAVKF Sbjct: 486 VKFDFFNLLEKTYKAHIVQANEKGLRLSYTVQKGIPRILVGDPGRLQQVLNNLISNAVKF 545 Query: 535 TYTGGIKVTLRVLARAGGSVTLEFTVADTGIGIPESSRSRLFEPFYQLDHFIDRRHEGTG 594 T G +++ + ++ + SV L+FTV+DTGIGI + LF+ F Q+D I R++ GTG Sbjct: 546 TDIGEVRIDVDIIEKRDDSVKLKFTVSDTGIGIDGDKMNMLFKSFSQVDSSITRKYGGTG 605 Query: 595 LGLAITRQLVEMMGGSIALDTTVETGASFVFTVKLREESGSLPDSASGTEGDEALSGERS 654 LGLAI++QLVEMMGG I +++ G++F FT + ++ S + + DE + G R Sbjct: 606 LGLAISKQLVEMMGGEIWVESQKGKGSTFYFTAGFKRKAKSSVKAECTSNADERVLG-RK 664 Query: 655 LRILVAEDNEINQIVLRKILEKRGYSVDVAGDGLQVMEMAREQSYDLIFMDVQMPRMNGL 714 L IL+AED+++NQ V+ +L+K S+ +A +G + +++ E +DLI MDVQMP M+G+ Sbjct: 665 LNILLAEDDKVNQQVIAGMLKKEQCSLTIAENGFEAIKLFEENEFDLILMDVQMPEMDGI 724 Query: 715 EATQAIKETLPPDKQPV-IIAVTANALKGDRELCLAAGMDEYISKPLRSEAI 765 EAT+ I++ + + IIAVTA A + DRE L AGMD+YISKP + I Sbjct: 725 EATKRIRKMEEGTFRHIPIIAVTAFAFENDREKILEAGMDDYISKPFSFDDI 776 >ref|ZP_00097625.1| COG2202: FOG: PAS/PAC domain [Desulfitobacterium hafniense] Length = 896 Score = 317 bits (812), Expect = 8e-85, Method: Compositional matrix adjust. Identities = 208/549 (37%), Positives = 309/549 (56%), Gaps = 38/549 (6%) Query: 254 VLAVGRDITERKIVEQKLQESVERYTSLKKYNHDAIISLDLE-----GRIINGNEKACQL 308 +L++ RDI+ +K + + L S +Y L DA+ +L+ G +I NEKA +L Sbjct: 234 LLSIARDISNQKRIHKILLASHNKYRQLFDNITDAVFVYELQKDGYPGLLIEINEKARRL 293 Query: 309 TGY---------------SIPELAGMNVGRIIGAEHLG--EVIAYSKEGS--PAEVNIDH 349 GY S P+L +V + + H E I + EG P EVN H Sbjct: 294 MGYHEETFMFSAGPCIRPSSPQLTLDDVWQSLERTHSASFEGICTNLEGEDIPVEVNC-H 352 Query: 350 IWHREGYSVEVLTTIAPIIINQETVGLYIIAKDITDQXXXXXXXXXXXXTNRAKSEFLAM 409 + G V +LT + I ++ I + + NRAKSEFLA Sbjct: 353 TFPLNGSKV-MLTLLRDITERKQ-----IEQERKRTEAEFQQAKEKAEAANRAKSEFLAN 406 Query: 410 MSHEIRTPMNGVIGMTDLLLEMSEPGSLQREYLDIIRQSGDTLLAIINDVLDFSKIEAGK 469 MSHEIRTP+NG+IGM DL L ++ QRE L I + +L IIND+LDFSKIEAGK Sbjct: 407 MSHEIRTPINGIIGMIDLTL-LTSLEKTQRENLKIAKNCAYSLFKIINDILDFSKIEAGK 465 Query: 470 TILHEEPFMLMPCVDSVLELLQHKADKKGLKIEVSIGPDVPEHLIGDGERLKQILLNLVG 529 + E F L ++ +++ +A++KGL + ++ ++P++ GD ER+KQ+L NL+ Sbjct: 466 LTVEEIEFNLKEVIEQIIKTHSPEAERKGLDLAYTLSANLPDYYKGDPERIKQVLNNLLS 525 Query: 530 NAVKFTYTGGIKVTLRVLARAGGSVTLEFTVADTGIGIPESSRSRLFEPFYQLDHFIDRR 589 NA+KFT G + + ++ L L+FTV DTGIGI E + LFE F Q+D I R+ Sbjct: 526 NALKFTERGEVSLAVKRLQGDEDVSDLKFTVMDTGIGIAEEDQLHLFEEFNQVDGSITRK 585 Query: 590 HEGTGLGLAITRQLVEMMGGSIALDTTVETGASFVFTVKLREESGSLPDSASGTEGDEAL 649 + GTGLGLAI+R+LVEMMGG I +++ G+SF ++L+ S D++ Sbjct: 586 YGGTGLGLAISRKLVEMMGGRIWVESEKGKGSSFGVVLRLKHGDKDTLRFKSTQNNDQSR 645 Query: 650 SGE--RSLRILVAEDNEINQIVLRKILEKRGYSVDVAGDGLQVMEMAREQSYDLIFMDVQ 707 G RS RIL+AED+ +N IV+ ++L+ +G+ VD+A DG + + + + YD+I MD+Q Sbjct: 646 EGSTARSYRILLAEDHIVNSIVITEMLKIQGHRVDIAMDGEEALALYHQNPYDVILMDIQ 705 Query: 708 MPRMNGLEATQAIKETLPPDKQPVIIAVTANALKGDRELCLAAGMDEYISKPLRSE---- 763 +PR++G+E T+ I+ + + IIA+TA AL+GDRE L AGMDEYI KP+ E Sbjct: 706 LPRLDGIEVTKRIRASEGAQSRTPIIALTAYALQGDREGFLQAGMDEYIPKPVMMEELIM 765 Query: 764 AITNIVGKF 772 + +V KF Sbjct: 766 VLDRVVTKF 774 >ref|NP_951775.1| sensory box histidine kinase/response regulator [Geobacter sulfurreducens PCA] gb|AAR34048.1| sensory box histidine kinase/response regulator [Geobacter sulfurreducens PCA] Length = 589 Score = 304 bits (779), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 196/554 (35%), Positives = 295/554 (53%), Gaps = 51/554 (9%) Query: 263 ERKIVEQKLQESVERYTSLKKYNHDAIISLDLEGRIINGNEKACQLTGYSIPELAGMNVG 322 E + + +L+ S+ERY +L + ++D G I + N + G E+ G+ Sbjct: 38 ELRDIRAQLELSLERYANLYHFAPVGYATIDAVGVIADANRTLAGMIGADCREMVGLLFS 97 Query: 323 RIIGAEHLGEVIAY------SKEGSPAEVNIDHIWHREGYSVEVLTTIAPIIINQETVGL 376 + + + +++ +EG E + R G SV+V + P+ V Sbjct: 98 DFVHKDDVTSFVSHLARCTGQREGVTGEFRLSG---RNGISVDVQLSSMPLTPPGGRVSC 154 Query: 377 YIIAKDIT-----------DQXXXXXXXXXXXXTNRAKSEFLAMMSHEIRTPMNGVIGMT 425 DIT + +RAKSEFLA MSHEIRTP+NGV+GM Sbjct: 155 RTAITDITMIKRKERELNESREELCWAKEAAEDASRAKSEFLANMSHEIRTPINGVLGML 214 Query: 426 DLLLEMSEPGSLQREYLDIIRQSGDTLLAIINDVLDFSKIEAGKTILHEEPFMLMPCVDS 485 L+L+ +E G QR L++ ++S D LL ++ND+LDFS+IEA K + PF L CV+S Sbjct: 215 QLVLD-TELGDEQRHCLEMAKRSADALLRLVNDILDFSRIEARKMVFESRPFDLTACVNS 273 Query: 486 VLELLQHKADKKGLKIEVSIGPDVPEHLIGDGERLKQILLNLVGNAVKFTYTGGIKVTLR 545 +E+L +A +KGL + V +GPDVP ++GD RL+Q+L+NL+GNAVKFT G ++VT Sbjct: 274 AVEILAFEARRKGLAVMVRMGPDVPAAVVGDEARLRQVLVNLIGNAVKFTDRGKVEVTAA 333 Query: 546 VLARAGGSV--TLEFTVADTGIGIPESSRSRLFEPFYQLDHFIDRRHEGTGLGLAITRQL 603 R + + +V DTGIGI R RLF F Q+D +RR GTGLGLA+TR + Sbjct: 334 RAERQSDPLRTAIRISVRDTGIGIAPQERERLFRVFSQVDGACNRRFGGTGLGLALTRDI 393 Query: 604 VEMMGGSIALDTTVETGASFVFTVKL----REESGSLP--------DSASGTEG------ 645 VE MGG+I +++ G++F T+ L S LP SA G G Sbjct: 394 VEAMGGAIDVESQSGQGSTFTITIPLLLAVTASSPFLPADTLRIAEASAGGGTGAPVTPP 453 Query: 646 -----DEALSGERSLRILVAEDNEINQIVLRKILEKRGYSVDVAGDGLQVMEMAREQSYD 700 +EA R ++IL+AED+ I + + +LE+R + + A DG + +E +D Sbjct: 454 ISIQYEEA----RKVKILLAEDDPITRKFMEIMLERRNFEFESASDGHEAVEKWEAGEFD 509 Query: 701 LIFMDVQMPRMNGLEATQAIKETLPPDKQPV-IIAVTANALKGDRELCLAAGMDEYISKP 759 ++ MDVQMPR++G EAT I+E + IIA+TA+A++ D + CL AGMD Y+SKP Sbjct: 510 VVLMDVQMPRLDGYEATGLIRERERDRGRRTPIIALTAHAMRKDEDRCLDAGMDGYLSKP 569 Query: 760 LRSEAITNIVGKFF 773 + + +G+ Sbjct: 570 IDFTKLMECIGEIL 583 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.319 0.136 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 1,065,352,400 Number of extensions: 43060016 Number of successful extensions: 145767 Number of sequences better than 1.0e-05: 6743 Number of HSP's gapped: 135934 Number of HSP's successfully gapped: 7317 Length of query: 773 Length of database: 757,237,578 Length adjustment: 134 Effective length of query: 639 Effective length of database: 393,414,312 Effective search space: 251391745368 Effective search space used: 251391745368 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 130 (54.7 bits)