BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0341.0037.p (594 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_244314.1| two-component sensor histidine kinase [Bacillus... 185 2e-45 ref|NP_358173.1| Histidine kinase [Streptococcus pneumoniae R6] ... 159 3e-37 ref|NP_345167.1| sensor histidine kinase, putative [Streptococcu... 158 3e-37 ref|NP_782429.1| two-component sensor kinase yesM [Clostridium t... 157 6e-37 ref|NP_388576.1| similar to two-component sensor histidine kinas... 148 4e-34 >ref|NP_244314.1| two-component sensor histidine kinase [Bacillus halodurans] pir||G84080 two-component sensor histidine kinase BH3447 [imported] - Bacillus halodurans (strain C-125) dbj|BAB07166.1| two-component sensor histidine kinase [Bacillus halodurans] Length = 602 Score = 185 bits (470), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 147/598 (24%), Positives = 274/598 (45%), Gaps = 44/598 (7%) Query: 8 VPLRTKFIVLFCLLITVPFLVIGAISYKKYTAGVERSTVELSYQVVNQININLEHYIKEL 67 +P+R K ++ F L+ +P L++ + +E+ E + Q+++++N +E +I+ + Sbjct: 10 LPIRFKLVIHFLLISILPSLLLAVLVGWAVDRIIEQQVNENTLQLIDKVNSTIEAHIENV 69 Query: 68 DRLTLMPLYDEDVMHILQSHSGSGSASTYLTTDETLKMNLFISSLAFDRGEIESILVFTN 127 +T ++ L +L DE +++ F+ + EI ILV Sbjct: 70 QNMTYFISLHSNIQQFLDG------TLEHLGPDEEYEISKFLQNFTTLYPEIAGILVVNQ 123 Query: 128 DGGIFSNLDQSVRKRWDRSMAEWMGSVKQEDGGLAII-PPH-----NAAYYTEPKQGIIS 181 G SN + R ++ + W + G +I P + +Y E + +++ Sbjct: 124 QGDYLSN-ELYTRSSFNLNQESWYRQAVENKGIAKLIGKPQGRRITSHVHYREDE--VVT 180 Query: 182 VARVIREPYTNKMLGIVKVDLTPQGFGSILSTVRLGGSGLLQITGKDQVMLYSAAAGL-- 239 V R I + T + G++ +DL + + VRLG SG L + + +YS A + Sbjct: 181 VVRAIIDSTTGEEKGVILIDLKLRVIEEAVRDVRLGKSGYLMVVDQKGDPIYSPAPSIMY 240 Query: 240 -----------------PDSSESYITASAQSAYTGLKVTSLIPRTQLREDARELTNSTLI 282 E Y QSA+TG + + Q E+ +++ + Sbjct: 241 EQSFDHRFSQNYGIFTEEVEGERYQLMYQQSAFTGWTLIGVFSTDQSVEEVQQILFYVVT 300 Query: 283 VSXXXXXXXXXXXXXXSNRLIKPIAHLQSKMRQVKRGLFRERATVTTNDEIGQLTEGFNT 342 S + +PI L M++ + G R DE+G+L FNT Sbjct: 301 FVFFVCFVGITASYFLSYTISRPINQLMLAMQKAESGDLTSRYEGEEQDEVGRLGRSFNT 360 Query: 343 MIGEIDRLVKEVYXXXXXXXXXXXXXXQSQIHPHFLYNTLEMVNMLALQGSTRELSGVVT 402 MI +I +L+ Q+ I PHFLYNTL+ + +A + + +++ +V Sbjct: 361 MIEQIGKLISLTERQERKKREAELHSLQANIKPHFLYNTLDTIQWMARKKNASDVADLVG 420 Query: 403 SLGKLLRYTVGRQDPMVYVLDEVKFVEAYLKIQGMRLGDKLQAVIHMDSSFDYCLVPKLI 462 +L KL R + + ++ ++DE++ ++ YL+IQ +R +KL + M S+ + + K++ Sbjct: 421 ALSKLFRIGLSKGGTIIPLVDEIEHIKNYLQIQSVRYKNKLNYSLVMPSNMERLSILKIV 480 Query: 463 LQPLIENVIEHAM----GPDTVHLALTAAVQEDDLILSVKDDGIGISGERMKELEEQLYR 518 LQP++EN I H + GP + + A + D LI+ ++D+G GI E + +QL Sbjct: 481 LQPIVENAIYHGIKERRGPGLI--TIEAERENDMLIIRIRDNGKGIKPETL----QQLRT 534 Query: 519 DKSRSVPESEPGGFGRIRKGFALRNVHQRLRLLYGEPYGLYIDNTAERGVTISLRLPM 576 + + + + + G R+ KG+ L NVH RLRL +GEPYG+ ID+ G +++ P+ Sbjct: 535 NVNLFLEKGDKEGGQRLTKGYGLINVHARLRLTFGEPYGVKIDSVFNEGTVVTIFHPI 592 >ref|NP_358173.1| Histidine kinase [Streptococcus pneumoniae R6] pir||C97944 histidine kinase (EC 2.7.3.-) [imported] - Streptococcus pneumoniae (strain R6) gb|AAK99383.1| Histidine kinase [Streptococcus pneumoniae R6] Length = 563 Score = 159 bits (401), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 144/597 (24%), Positives = 270/597 (45%), Gaps = 67/597 (11%) Query: 1 MSKKSIYVPLRTKFIVLFCLLITVPFLVIGAISYKKYTAGVERSTVELSYQVVNQININL 60 M + S+ V + ++F +L+ + +G Y+ ++ +E + S ++Q + + Sbjct: 1 MKRSSLLVRMVISIFLVFLILLAL----VGTFYYQSSSSAIEATIEGNSQTTISQTSHFI 56 Query: 61 EHYIKELDRLTLMPLYDEDVMHILQSHSGSGSASTYLTTDETLKMNLFISSLAFDRGEIE 120 + YIK+L+ + DV+ ++ S +LF++ L D+ +++ Sbjct: 57 QSYIKKLETTSTGLTQQTDVLAYAENPSQDKVEGI---------RDLFLTILKSDK-DLK 106 Query: 121 SILVFTNDGGIFSNLDQSVRKRWDRSMAE-WMGSVKQEDGGLAIIPPHNAAYYTEPKQGI 179 ++++ T G + S D K MAE W + G + ++ P + Q + Sbjct: 107 TVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQ-GAMPVLTPARKS----DSQWV 161 Query: 180 ISVARVIREPYTNKMLGIVKVDLTPQGFGSILSTVRLGGSGLLQITGKD-------QVML 232 ISV + + + LG++++D++ + + L+ ++LG G I ++ Q + Sbjct: 162 ISVTQELVDA-KGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQHTV 220 Query: 233 YSAAA-------------GLPDSSESYITAS--AQSAYTGLKVTSLIPRTQLREDARELT 277 YS+++ G +SY++ A + +T L V+SL Q+R +L Sbjct: 221 YSSSSKMEAMKPYIETGQGYTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRS---QLL 277 Query: 278 NSTLIVSXXXXXXXXXXXXXXSNRLIKPIAHLQSKMRQVKRGLFRERATVTTNDEIGQLT 337 + L S R I P+ L+ M ++ G RA E+ ++T Sbjct: 278 WTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQNLRAKEVGAYELREVT 337 Query: 338 EGFNTMIGEIDRLVKEVYXXXXXXXXXXXXXXQSQIHPHFLYNTLEMVNMLALQGSTREL 397 FN M+ +ID+L+ + SQI+PHFLYNTL+ + +A ++ + Sbjct: 338 RQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFHDSQRV 397 Query: 398 SGVVTSLGKLLRYTVGRQDPMVYVLDEVKFVEAYLKIQGMRLGDKLQAVIHMDSSFDYCL 457 V SL R + + ++ + DE+ V YL IQ R GDKL+ I+ + +FD + Sbjct: 398 VQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINENVAFDNLV 457 Query: 458 VPKLILQPLIENVIEHAMGPD--TVHLALTAAVQEDDLILSVKDDGIGISGERMKELEEQ 515 +PKL+LQPL+EN + H + H+ L+ Q+ L++ ++DDG+G Q Sbjct: 458 LPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVGF----------Q 507 Query: 516 LYRDKSRSVPESEPGGFGRIRKGFALRNVHQRLRLLYGEPYGLYIDNTAERGVTISL 572 D S+S + R G L+NV QRL+L +G Y + ID+ ++G + + Sbjct: 508 DAGDSSQSQLK---------RGGVGLQNVDQRLKLHFGANYQMKIDSRPQKGTKVEI 555 >ref|NP_345167.1| sensor histidine kinase, putative [Streptococcus pneumoniae TIGR4] pir||F95076 sensor histidine kinase, probable [imported] - Streptococcus pneumoniae (strain TIGR4) emb|CAB54581.1| histidine kinase [Streptococcus pneumoniae] gb|AAF31453.1| putative histidine kinase [Streptococcus pneumoniae] gb|AAK74807.1| sensor histidine kinase, putative [Streptococcus pneumoniae TIGR4] Length = 563 Score = 158 bits (400), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 144/597 (24%), Positives = 270/597 (45%), Gaps = 67/597 (11%) Query: 1 MSKKSIYVPLRTKFIVLFCLLITVPFLVIGAISYKKYTAGVERSTVELSYQVVNQININL 60 M + S+ V + ++F +L+ + +G Y+ ++ +E + S ++Q + + Sbjct: 1 MKRSSLLVRMVISIFLVFLILLAL----VGTFYYQSSSSAIEATIEGNSQTTISQTSHFI 56 Query: 61 EHYIKELDRLTLMPLYDEDVMHILQSHSGSGSASTYLTTDETLKMNLFISSLAFDRGEIE 120 + YIK+L+ + DV+ ++ S +LF++ L D+ +++ Sbjct: 57 QSYIKKLETTSTGLTQQTDVLAYAENPSQDKVEGI---------RDLFLTILKSDK-DLK 106 Query: 121 SILVFTNDGGIFSNLDQSVRKRWDRSMAE-WMGSVKQEDGGLAIIPPHNAAYYTEPKQGI 179 ++++ T G + S D K MAE W + G + ++ P + Q + Sbjct: 107 TVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQ-GAMPVLTPARKS----DSQWV 161 Query: 180 ISVARVIREPYTNKMLGIVKVDLTPQGFGSILSTVRLGGSGLLQITGKD-------QVML 232 ISV + + + LG++++D++ + + L+ ++LG G I ++ Q + Sbjct: 162 ISVTQELVDA-KGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQHTV 220 Query: 233 YSAAA-------------GLPDSSESYITAS--AQSAYTGLKVTSLIPRTQLREDARELT 277 YS+++ G +SY++ A + +T L V+SL Q+R +L Sbjct: 221 YSSSSKMEAMKPYIDTGQGYTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRS---QLL 277 Query: 278 NSTLIVSXXXXXXXXXXXXXXSNRLIKPIAHLQSKMRQVKRGLFRERATVTTNDEIGQLT 337 + L S R I P+ L+ M ++ G RA E+ ++T Sbjct: 278 WTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQNLRAKEVGAYELREVT 337 Query: 338 EGFNTMIGEIDRLVKEVYXXXXXXXXXXXXXXQSQIHPHFLYNTLEMVNMLALQGSTREL 397 FN M+ +ID+L+ + SQI+PHFLYNTL+ + +A ++ + Sbjct: 338 RQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFHDSQRV 397 Query: 398 SGVVTSLGKLLRYTVGRQDPMVYVLDEVKFVEAYLKIQGMRLGDKLQAVIHMDSSFDYCL 457 V SL R + + ++ + DE+ V YL IQ R GDKL+ I+ + +FD + Sbjct: 398 VQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINENVAFDNLV 457 Query: 458 VPKLILQPLIENVIEHAMGPD--TVHLALTAAVQEDDLILSVKDDGIGISGERMKELEEQ 515 +PKL+LQPL+EN + H + H+ L+ Q+ L++ ++DDG+G Q Sbjct: 458 LPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVGF----------Q 507 Query: 516 LYRDKSRSVPESEPGGFGRIRKGFALRNVHQRLRLLYGEPYGLYIDNTAERGVTISL 572 D S+S + R G L+NV QRL+L +G Y + ID+ ++G + + Sbjct: 508 DAGDSSQSQLK---------RGGVGLQNVDQRLKLHFGANYHMKIDSRPQKGTKVEI 555 >ref|NP_782429.1| two-component sensor kinase yesM [Clostridium tetani E88] gb|AAO36366.1| two-component sensor kinase yesM [Clostridium tetani E88] Length = 577 Score = 157 bits (398), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 99/362 (27%), Positives = 171/362 (47%), Gaps = 32/362 (8%) Query: 217 GGSGLLQITGKDQVMLYSAAAGLPDSSESYITASAQSAYTGLKVTSLIPRTQLREDAREL 276 G L + KD + +S+ +E++I + ++ ++ ++ Sbjct: 237 GTVALKNVHNKDSTVFFSSVP----YTENWI------------LCIIVENKKIHTQINQI 280 Query: 277 TNSTLIVSXXXXXXXXXXXXXXSNRLIKPIAHLQSKMRQVKRGLFRERATVTTNDEIGQL 336 N L V S ++KPI L+S M ++ +G F + NDEI L Sbjct: 281 INLILFVGLILLLAAILLSIVISGSIVKPIHRLKSNMLEISKGNFDSYYEIKNNDEISIL 340 Query: 337 TEGFNTMIGEIDRLVKEVYXXXXXXXXXXXXXXQSQIHPHFLYNTLEMVNMLALQGSTRE 396 + FN M+ +I RL+ +VY QSQI+PHFLYNTL+ + AL+ + E Sbjct: 341 GQVFNQMLTDIKRLINKVYQVEKQKRSAELRVLQSQINPHFLYNTLDTIQWKALEYNAFE 400 Query: 397 LSGVVTSLGKLLRYTVGRQDPMVYVLDEVKFVEAYLKIQGMRLGDKLQAVIHMDSSFDYC 456 + ++ L R ++ + + DEV V YL+IQ +R DK+ + +DSS D Sbjct: 401 VVDMINYLSNFFRISLSDGKEFITISDEVAHVSNYLEIQKIRYKDKISYSMDVDSSLDQY 460 Query: 457 LVPKLILQPLIENVIEHAMGPDTVHLALTAAVQEDD--LILSVKDDGIGISGERMKELEE 514 L+PKLI+QPL+EN I H + + ++ D L + V D+G+G+ E+++ L + Sbjct: 461 LIPKLIVQPLVENSIYHGLKLQKHKGIINVSISSKDGFLFIKVIDNGLGMDVEQLRTLRK 520 Query: 515 QLYRDKSRSVPESEPGGFGRIRKGFALRNVHQRLRLLYGEPYGLYIDNTAERGVTISLRL 574 L+ E +G L N+++RL+L +G+ Y + I + + G + LR+ Sbjct: 521 NLWE-------SIETNHYG-------LYNINERLKLAFGKKYSIEIKSELKIGTQVLLRI 566 Query: 575 PM 576 P+ Sbjct: 567 PL 568 >ref|NP_388576.1| similar to two-component sensor histidine kinase [YesN] [Bacillus subtilis] pir||D69796 two-component sensor histidine kinase homolog yesM - Bacillus subtilis emb|CAB12514.1| yesM [Bacillus subtilis subsp. subtilis str. 168] Length = 577 Score = 148 bits (373), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 144/616 (23%), Positives = 261/616 (42%), Gaps = 92/616 (14%) Query: 8 VPLRTKFIVLFCLLITVPFLVIGA---ISYKKYTAGVERSTVELSYQVVNQININLEHYI 64 + ++ K V L++ V FL + + ++ Y + R + E V+ + +E + Sbjct: 12 MKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVYDEQIYRKSSE----VLRMSSERIEDEL 67 Query: 65 KELDRLTLMPLYDEDVMHILQSHSGSGSASTYLTTDETLKMNLFISSLAFDRGEIESILV 124 K+++ ++ + DE + IL + + Y E ++ A D I+SI V Sbjct: 68 KKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMKQELWDQ---LAGYASDEKYIDSIHV 124 Query: 125 FTNDGGIFSN-------LDQSVRKRWDRSMAEWMGSVKQEDGGLAIIPPHNAAYYTEPKQ 177 G +S L Q + + R+ A+ ++ GG ++P Sbjct: 125 IDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRNLWMTLGG------------SDP-- 170 Query: 178 GIISVARVIREPYTNKM--LGIVKVDLT--------PQGFGSILSTVRLGGSGLLQITGK 227 ++ AR IR + + LG+V + + P+ +G + + + G Sbjct: 171 -VLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMIADQG------G 223 Query: 228 DQVMLYSAAAGLPDSSES----------------YITASAQSAYTGLKVTSLIPRTQLRE 271 + V A+A +P++++ Y + QS+Y ++IP Q+ Sbjct: 224 NLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVIPFDQMFA 283 Query: 272 DARELTNSTLIVSXXXXXXXXXXXXXXSNRLIKPIAHLQSKMRQVKRGLFRERATVT--- 328 + +N + +PI L + M+ V+ +++ Sbjct: 284 KISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIEAGVSLSLPE 343 Query: 329 -TNDEIGQLTEGFNTMIGEIDRLVKEVYXXXXXXXXXXXXXXQSQIHPHFLYNTLEMVNM 387 T DE G L F M+ I+ L++E Q+QI+PHFLYNTLE +N Sbjct: 344 HTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPHFLYNTLESINW 403 Query: 388 LALQGSTRELSGVVTSLGKLLRYTVGRQDPMVYVLDEVKFVEAYLKIQGMRLGDKLQAVI 447 LA +++S +V SLG LLR ++ + +V + +E V Y+ IQ R ++L+ + Sbjct: 404 LAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTIQRFRFEERLKFTL 463 Query: 448 HMDSSFDYCLVPKLILQPLIENVIEHAMGPDTVHLA--LTAAVQEDDLILSVKDDGIGIS 505 +D +CL+PKL LQPL EN I++A+ P T A + A + + ++V+D+G G+ Sbjct: 464 DIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAKGCVCITVEDNGPGMD 523 Query: 506 GERMKELEEQLYRDKSRSVPESEPGGFGRIRKGFALRNVHQRLRLLYGEPYGLYIDNTAE 565 G + ES G +G L N+ +R+ L +GEPYGL I + E Sbjct: 524 GR----------------ILESTGG------RGIGLWNIRERISLTFGEPYGLRIHSEHE 561 Query: 566 RGVTISLRLPMHWEAL 581 +G I + +P E + Sbjct: 562 KGTRIVITIPCRNEVV 577 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.318 0.136 0.382 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 790,549,820 Number of extensions: 32082507 Number of successful extensions: 83185 Number of sequences better than 1.0e-05: 187 Number of HSP's gapped: 82907 Number of HSP's successfully gapped: 187 Length of query: 594 Length of database: 757,237,578 Length adjustment: 131 Effective length of query: 463 Effective length of database: 401,559,609 Effective search space: 185922098967 Effective search space used: 185922098967 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 129 (54.3 bits)