BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0181.0002.p (534 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_815879.1| DNA-binding response regulator, AraC family [En... 94 1e-17 ref|NP_563003.1| two-component response regulator [Clostridium p... 86 2e-15 ref|NP_607656.1| putative two-component sensor response regulato... 84 6e-15 ref|NP_801837.1| putative two-component response regulator [Stre... 84 7e-15 ref|NP_665090.1| putative two-component sensor response regulato... 84 7e-15 >ref|NP_815879.1| DNA-binding response regulator, AraC family [Enterococcus faecalis V583] gb|AAO81949.1| DNA-binding response regulator, AraC family [Enterococcus faecalis V583] Length = 493 Score = 93.6 bits (231), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 48/123 (39%), Positives = 68/123 (55%) Query: 1 MIIVDDEAHWVDNLSMTKPWHTLGIEQVHKAYSASEALQIIETHPIDIVISDIQMPEMTG 60 ++ VDDE ++ L PW LG E V A SA EAL +ET ID++++DI MPEM+G Sbjct: 4 VMFVDDEYMILEGLKWIIPWQELGFEIVKTARSAQEALAFLETESIDVLLTDITMPEMSG 63 Query: 61 LELMEXXXXXXXXXXXXXLSGHSEFEFAKSAIQHSAVDYLLKPPTDSELLGAVQTAIAQL 120 +EL+E LSG+ EF++ K + DYLLKP ELL +Q +L Sbjct: 64 IELIEQAKKKGHQFISLILSGYQEFDYVKKGMALQVQDYLLKPVNKQELLANIQRIKIEL 123 Query: 121 NAE 123 + + Sbjct: 124 DQQ 126 Score = 72.4 bits (176), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 93/166 (56%), Gaps = 6/166 (3%) Query: 366 FLITAAFSNLAHRNGHTLAKLLGTDIEELQSGEAFTSINKLRVWSLSVLGKLKEGTSSEI 425 +++ FS+++ + L + +EE+++ ++N L VL ++K +I Sbjct: 323 YVVFLLFSDISRQYPTVLEENYEKIVEEIRAS---NNLNTLYALMQQVLAEVK--NKPKI 377 Query: 426 KDIRSLYVKKIQEFTDKNLHLDVSLRVLADHVNLHPTHLSKIYKIETGEGISEYISRLRM 485 K S V + E ++ +++L+ +AD ++L+P++L +I+K ET S+Y++++R Sbjct: 378 KKY-SESVSQAVERIEQGYLEELNLKTVADELHLNPSYLGQIFKKETKRSFSQYLNQVRT 436 Query: 486 DRACHMLKTTGKKVYEISNDIGYMDPAYFIKVFKRQFGVTPQEYRD 531 A +L T + EIS +G+ + YF K+FK+ G+TP+E+R+ Sbjct: 437 KHAQKLLLYTDDTINEISEKVGFNNTNYFSKMFKKLNGITPKEFRE 482 >ref|NP_563003.1| two-component response regulator [Clostridium perfringens] dbj|BAB81793.1| two-component response regulator [Clostridium perfringens str. 13] Length = 507 Score = 86.3 bits (212), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 43/125 (34%), Positives = 71/125 (56%) Query: 1 MIIVDDEAHWVDNLSMTKPWHTLGIEQVHKAYSASEALQIIETHPIDIVISDIQMPEMTG 60 +++ DDE + L W LG+E V+KA + EA+ + +P+DIV++DI MP++TG Sbjct: 4 VMLADDENLILQGLENIIEWEELGLEIVNKASNGQEAIDKFKENPVDIVVTDINMPQVTG 63 Query: 61 LELMEXXXXXXXXXXXXXLSGHSEFEFAKSAIQHSAVDYLLKPPTDSELLGAVQTAIAQL 120 LEL++ LSG+ +F +AK AI+ +Y+LKP + EL ++ I ++ Sbjct: 64 LELLKELKKINSDVKFIILSGYDDFSYAKKAIELGVENYILKPIDEEELEKTLKNTINKI 123 Query: 121 NAEWE 125 E E Sbjct: 124 KQEKE 128 Score = 68.6 bits (166), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 29/101 (28%), Positives = 63/101 (62%) Query: 433 VKKIQEFTDKNLHLDVSLRVLADHVNLHPTHLSKIYKIETGEGISEYISRLRMDRACHML 492 +++I + ++N + +VSL+ LA +++ ++L +++ E G SEY+++ + +A ++ Sbjct: 405 IQQIISYVNENYYEEVSLKTLAQKYHINTSYLGQVFTKEVGCSFSEYLNKTKNMKAKELI 464 Query: 493 KTTGKKVYEISNDIGYMDPAYFIKVFKRQFGVTPQEYRDGK 533 T K+ +I+ +GY+D +YF + FK+ +GV P R+ K Sbjct: 465 LNTNMKINDIAKKVGYLDTSYFYRKFKKYYGVCPSTLRNIK 505 >ref|NP_607656.1| putative two-component sensor response regulator [Streptococcus pyogenes MGAS8232] gb|AAL98155.1| putative two-component sensor response regulator [Streptococcus pyogenes MGAS8232] Length = 494 Score = 84.3 bits (207), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 44/123 (35%), Positives = 67/123 (54%) Query: 1 MIIVDDEAHWVDNLSMTKPWHTLGIEQVHKAYSASEALQIIETHPIDIVISDIQMPEMTG 60 +++VDDE + L+M W LG E V A S EAL + +P+D++ISD+ MP MTG Sbjct: 4 VLLVDDEYMILQGLTMIIDWQALGFEVVQTARSGKEALTYLTQYPVDVMISDVTMPGMTG 63 Query: 61 LELMEXXXXXXXXXXXXXLSGHSEFEFAKSAIQHSAVDYLLKPPTDSELLGAVQTAIAQL 120 L+L+E LSG+ EF + + A++ YLLKP +EL ++ L Sbjct: 64 LDLIEAAKTYHPQLQTLILSGYQEFSYVQKAMELETKGYLLKPVDKAELQAKMKQFKDCL 123 Query: 121 NAE 123 +A+ Sbjct: 124 DAQ 126 Score = 68.9 bits (167), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 60/93 (64%) Query: 442 KNLHLDVSLRVLADHVNLHPTHLSKIYKIETGEGISEYISRLRMDRACHMLKTTGKKVYE 501 K H +++L+ +AD ++++ +L + +K ET ++Y++ +R+ +A +L T + + E Sbjct: 392 KEYHQELTLKAIADRLHVNGVYLGQCFKNETERSFTQYLNHVRIQKAQQLLLYTNQSINE 451 Query: 502 ISNDIGYMDPAYFIKVFKRQFGVTPQEYRDGKK 534 I+ + GY YFIK+FK+ G++P+E+RD K Sbjct: 452 IAYETGYNTNHYFIKMFKKLNGLSPKEFRDRYK 484 >ref|NP_801837.1| putative two-component response regulator [Streptococcus pyogenes SSI-1] dbj|BAC63670.1| putative two-component response regulator [Streptococcus pyogenes SSI-1] Length = 495 Score = 84.3 bits (207), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 44/123 (35%), Positives = 67/123 (54%) Query: 1 MIIVDDEAHWVDNLSMTKPWHTLGIEQVHKAYSASEALQIIETHPIDIVISDIQMPEMTG 60 +++VDDE + L+M W LG E V A S EAL + +P+D++ISD+ MP MTG Sbjct: 5 VLLVDDEYMILQGLTMIIDWQALGFEVVQTARSGKEALAYLTQYPVDVMISDVTMPGMTG 64 Query: 61 LELMEXXXXXXXXXXXXXLSGHSEFEFAKSAIQHSAVDYLLKPPTDSELLGAVQTAIAQL 120 L+L+E LSG+ EF + + A++ YLLKP +EL ++ L Sbjct: 65 LDLIEAAKTYHPQLQTLILSGYQEFSYVQKAMELETKGYLLKPVDKAELQAKMKQFKDCL 124 Query: 121 NAE 123 +A+ Sbjct: 125 DAQ 127 Score = 68.9 bits (167), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 60/93 (64%) Query: 442 KNLHLDVSLRVLADHVNLHPTHLSKIYKIETGEGISEYISRLRMDRACHMLKTTGKKVYE 501 K H +++L+ +AD ++++ +L + +K ET ++Y++ +R+ +A +L T + + E Sbjct: 393 KEYHQELTLKAIADRLHVNGVYLGQCFKNETERSFTQYLNHVRIQKAQQLLLYTNQSINE 452 Query: 502 ISNDIGYMDPAYFIKVFKRQFGVTPQEYRDGKK 534 I+ + GY YFIK+FK+ G++P+E+RD K Sbjct: 453 IAYETGYNTNHYFIKMFKKLNGLSPKEFRDRYK 485 >ref|NP_665090.1| putative two-component sensor response regulator [Streptococcus pyogenes MGAS315] gb|AAM79893.1| putative two-component sensor response regulator [Streptococcus pyogenes MGAS315] Length = 494 Score = 84.3 bits (207), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 44/123 (35%), Positives = 67/123 (54%) Query: 1 MIIVDDEAHWVDNLSMTKPWHTLGIEQVHKAYSASEALQIIETHPIDIVISDIQMPEMTG 60 +++VDDE + L+M W LG E V A S EAL + +P+D++ISD+ MP MTG Sbjct: 4 VLLVDDEYMILQGLTMIIDWQALGFEVVQTARSGKEALAYLTQYPVDVMISDVTMPGMTG 63 Query: 61 LELMEXXXXXXXXXXXXXLSGHSEFEFAKSAIQHSAVDYLLKPPTDSELLGAVQTAIAQL 120 L+L+E LSG+ EF + + A++ YLLKP +EL ++ L Sbjct: 64 LDLIEAAKTYHPQLQTLILSGYQEFSYVQKAMELETKGYLLKPVDKAELQAKMKQFKDCL 123 Query: 121 NAE 123 +A+ Sbjct: 124 DAQ 126 Score = 68.9 bits (167), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 60/93 (64%) Query: 442 KNLHLDVSLRVLADHVNLHPTHLSKIYKIETGEGISEYISRLRMDRACHMLKTTGKKVYE 501 K H +++L+ +AD ++++ +L + +K ET ++Y++ +R+ +A +L T + + E Sbjct: 392 KEYHQELTLKAIADRLHVNGVYLGQCFKNETERSFTQYLNHVRIQKAQQLLLYTNQSINE 451 Query: 502 ISNDIGYMDPAYFIKVFKRQFGVTPQEYRDGKK 534 I+ + GY YFIK+FK+ G++P+E+RD K Sbjct: 452 IAYETGYNTNHYFIKMFKKLNGLSPKEFRDRYK 484 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.318 0.135 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 742,885,253 Number of extensions: 29211211 Number of successful extensions: 88738 Number of sequences better than 1.0e-05: 424 Number of HSP's gapped: 89484 Number of HSP's successfully gapped: 461 Length of query: 534 Length of database: 757,237,578 Length adjustment: 130 Effective length of query: 404 Effective length of database: 404,274,708 Effective search space: 163326982032 Effective search space used: 163326982032 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 128 (53.9 bits)