BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0167.0008.p (517 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_242776.1| two-component response regulator [Bacillus halo... 297 4e-79 ref|NP_563003.1| two-component response regulator [Clostridium p... 163 1e-38 ref|NP_815879.1| DNA-binding response regulator, AraC family [En... 159 1e-37 ref|NP_241659.1| two-component sensor response regulator [Bacill... 117 5e-25 ref|NP_388577.1| similar to two-component response regulator [Ye... 109 1e-22 >ref|NP_242776.1| two-component response regulator [Bacillus halodurans] pir||F83888 two-component response regulator BH1910 [imported] - Bacillus halodurans (strain C-125) dbj|BAB05629.1| two-component response regulator [Bacillus halodurans] Length = 506 Score = 297 bits (761), Expect = 4e-79, Method: Compositional matrix adjust. Identities = 187/522 (35%), Positives = 270/522 (51%), Gaps = 34/522 (6%) Query: 2 MIKVLIVDDEPKLREGLRALIPWGQLGFTVVATAANGLQALEKYHIHDPELIVVDIRMPG 61 M V+IVDDE +REGL+ALI W + GF V+ TA NG + KY P+L++VDIRMP Sbjct: 1 MYDVMIVDDEAMVREGLKALISWEEYGFRVIDTARNGKEGFTKYRQLSPDLMIVDIRMPE 60 Query: 62 MDGLELIGELRNEGSTSHVLILSGHADFDYAKRAIGYRIDGYLLKPVDEEEMISLLKELR 121 +DGL LI +R E S H +ILSGH+DF+YAK+A+G + D YLLKP+DE+E+I LK++ Sbjct: 61 VDGLSLIESIRAEDSAIHFIILSGHSDFNYAKKALGCQCDDYLLKPLDEDELIDSLKKVY 120 Query: 122 ETIDREDRFSRWNEEEPTRNRESLLRALLQ-------PPAEESGADDPGKQAAALGLTPG 174 I R + E + E +L LL+ P +E Q A + Sbjct: 121 GRITRHHQVHELVERVQEKQVEMVLTELLEGTPLSEIPIGKEHNFFATDYQVALVENRQD 180 Query: 175 RVEVVLIELLAPAHXXXXXXXXXXXXXXQHFSGSGDRLFFTLPPYIGLLLKEPLQDGMRR 234 R+ L L+ + P YI ++ K + Sbjct: 181 RLTKQLKRLIEE---------------------QEEGYVIPFPEYIVIVCKNRFLQKRGK 219 Query: 235 ERLIEELAGLICPCGFNFTAAAGGAVPRPEEAAESFNAARDLLRRAFFYRKGMMLTADP- 293 + A + + A AG V + ES+ +A+ L + FF KG + TAD Sbjct: 220 DHRYHLFAKWLEEEELH--ACAGSKVVNLADIYESYQSAKRLYEKKFFVEKGRLFTADQL 277 Query: 294 SGMLFPDSGEADTEQVTDAESRLLLAVETGSRAAIEPLVQAISAGLIAAGGEEQQIKDTF 353 P++ E E D RL +++ G+ +++ + +I EE++IK Sbjct: 278 VDRSKPEAPEFSLESYAD---RLYYSIDIGNMEGCVAIIEELKNVVIVHLQEEKEIKVAL 334 Query: 354 VRILSTVLARLEPVYPEIRNNTVKHFPPIGELYQSHYLEDLQEQSVAFLAEIAGQMTSGV 413 ++ S +L +L +P + G++YQ +L + L + M +G Sbjct: 335 FQLYSNILHQLVRSHPNMEGVLEPLVMNAGDIYQFEHLPGIMAFLTKQLKYVIDCMDNGQ 394 Query: 414 KGNEIKKITELIQRRYNENLKLETLSELFSYNSAYLGKMFKNTTGEYFNTYLDKVRIEKA 473 ++K+ LI + Y +NL+LETL+ +F+YN AYLGK+FKN TGEYFNTYLDKVRIE Sbjct: 395 PDLLLRKMIALIHKDYAKNLRLETLASVFNYNRAYLGKLFKNYTGEYFNTYLDKVRIENG 454 Query: 474 KEFLAQGMKVYEVAEKVGYMNSDYFNAKFRKYVGTSPSSFRK 515 K L +G KVYEVAEK+GY N DYF+ KF+KYVG SPS+FRK Sbjct: 455 KRLLQKGYKVYEVAEKIGYANVDYFHRKFKKYVGVSPSTFRK 496 >ref|NP_563003.1| two-component response regulator [Clostridium perfringens] dbj|BAB81793.1| two-component response regulator [Clostridium perfringens str. 13] Length = 507 Score = 163 bits (412), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 136/523 (26%), Positives = 243/523 (46%), Gaps = 31/523 (5%) Query: 2 MIKVLIVDDEPKLREGLRALIPWGQLGFTVVATAANGLQALEKYHIHDPELIVVDIRMPG 61 M KV++ DDE + +GL +I W +LG +V A+NG +A++K+ + +++V DI MP Sbjct: 1 MYKVMLADDENLILQGLENIIEWEELGLEIVNKASNGQEAIDKFKENPVDIVVTDINMPQ 60 Query: 62 MDGLELIGELRNEGSTSHVLILSGHADFDYAKRAIGYRIDGYLLKPVDEEEMISLLKELR 121 + GLEL+ EL+ S +ILSG+ DF YAK+AI ++ Y+LKP+DEEE+ LK Sbjct: 61 VTGLELLKELKKINSDVKFIILSGYDDFSYAKKAIELGVENYILKPIDEEELEKTLKNTI 120 Query: 122 ETIDREDRFSRWNEEEPTRNRESLLRALLQPPAEESGADDPGKQAAALGLTPGRVEVVLI 181 I +E E + + + ++L L++ + G + K+ + L R + +I Sbjct: 121 NKIKQEKE-----ENKSSLGKHNILIKLIKGKLAQ-GEIEENKEGFYMNLNSERYSLCII 174 Query: 182 ELLAPAHXXXXXXXXXXXXXXQHFSGSGDRLFFTLPPYIGLLLKEPLQDGMRRERLIEEL 241 + + + + + +TL L+L + + ++ + + Sbjct: 175 N--TRSRYDSEEMLHNIVNVIKENTQNNFEIIYTLDE--ELILINSWDEALSKKEIKKYY 230 Query: 242 AGL----ICPCGFNFTAAAGGAVPRPEEAAESFNAARDLLRRAFFYRKGMMLTADPSGML 297 L I G + + G V + + S+ A +L + +T + Sbjct: 231 DKLKEQIINEYGIDVFLSVGEPVCDLYKISSSYKEANNLKKYVLTLGYNKCITTED---- 286 Query: 298 FPDSGEADTE--QVTDAESRLLLAVET-GSRAAIEPLVQAISAGLIAAGGEEQQIKDTFV 354 D E + +V D ++ ++A + G+ IE V+ + I D V Sbjct: 287 VKDINEKNINFSEVLDKLNKRIIAKDIEGAEKIIEETVEDKKLN-------PRNIYDLSV 339 Query: 355 RILSTVLARLEPVYPEIRNNTVKHFPPIGELYQSHYLEDLQEQSVAFLAEIAGQM--TSG 412 +IL + +E E + I L ED++ + + E+ M T+ Sbjct: 340 KILFLLDGIVEEFKVEKQYTGNSLGEEIVALCSEDTREDIKTLLCSEIREVIELMHPTTI 399 Query: 413 VKGNEIKKITELIQRRYNENLKLETLSELFSYNSAYLGKMFKNTTGEYFNTYLDKVRIEK 472 I++I + Y E + L+TL++ + N++YLG++F G F+ YL+K + K Sbjct: 400 KYSPVIQQIISYVNENYYEEVSLKTLAQKYHINTSYLGQVFTKEVGCSFSEYLNKTKNMK 459 Query: 473 AKEF-LAQGMKVYEVAEKVGYMNSDYFNAKFRKYVGTSPSSFR 514 AKE L MK+ ++A+KVGY+++ YF KF+KY G PS+ R Sbjct: 460 AKELILNTNMKINDIAKKVGYLDTSYFYRKFKKYYGVCPSTLR 502 >ref|NP_815879.1| DNA-binding response regulator, AraC family [Enterococcus faecalis V583] gb|AAO81949.1| DNA-binding response regulator, AraC family [Enterococcus faecalis V583] Length = 493 Score = 159 bits (402), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 138/525 (26%), Positives = 244/525 (46%), Gaps = 54/525 (10%) Query: 2 MIKVLIVDDEPKLREGLRALIPWGQLGFTVVATAANGLQALEKYHIHDPELIVVDIRMPG 61 M +V+ VDDE + EGL+ +IPW +LGF +V TA + +AL ++++ DI MP Sbjct: 1 MYRVMFVDDEYMILEGLKWIIPWQELGFEIVKTARSAQEALAFLETESIDVLLTDITMPE 60 Query: 62 MDGLELIGELRNEGSTSHVLILSGHADFDYAKRAIGYRIDGYLLKPVDEEEMISLLKELR 121 M G+ELI + + +G LILSG+ +FDY K+ + ++ YLLKPV+++E+++ ++ ++ Sbjct: 61 MSGIELIEQAKKKGHQFISLILSGYQEFDYVKKGMALQVQDYLLKPVNKQELLANIQRIK 120 Query: 122 ETIDREDRFSRWNEEEPTRNR---ESLLRALLQPPAEESGADDPGKQAAALGLTPGRVEV 178 +D++ + R R E+ L L E ++ +Q A + PG V Sbjct: 121 IELDQQKK-------SHARVRLYLENGLMRWLNDEISEGEYEELMQQFAT--IKPGDFTV 171 Query: 179 VLIELLAPAHXXXXXXXXXXXXXXQHFSGSGDRLFF--TLPPYIGLLLKEPLQDGMRRER 236 +L+E + F G LF + Y LLL + G R+E Sbjct: 172 LLVE----------AEMSFLETIKELFMKKGQLLFIESWMSTYHQLLL---IYKGARQEA 218 Query: 237 --LIEELAGLICPCGFNFTAAAGGAVPRPEEAAESFNAARDLLRRAFFYRKGMMLTADPS 294 I E+ ++ G F G +V E ES+ + L FY++ Sbjct: 219 FLFIREIEAILAGQGQIF---VGESVNEWETVYESYEKVKQLQAIETFYQE--------- 266 Query: 295 GMLFPDSGEADTEQVTDAESRLLL--AVETGSRAAIEPLVQAISAGLIAAGGEEQQIKDT 352 P++ + + + + L A+ G I+ + AI L +Q Sbjct: 267 --FLPNNQKEQMNRSAEDFTFLAFNQALMIGDMQTIQRELDAIFNQL-----SQQHATPE 319 Query: 353 FVR-ILSTVLARLEPVYPEIRNNTVKHFPPIGELYQSHYLEDLQEQSVAFLAEIAGQMTS 411 +VR ++ + + + YP + + + E+ S+ L L LAE+ + Sbjct: 320 YVRYVVFLLFSDISRQYPTVLEENYEKI--VEEIRASNNLNTLYALMQQVLAEVKNKPKI 377 Query: 412 GVKGNEIKKITELIQRRYNENLKLETLSELFSYNSAYLGKMFKNTTGEYFNTYLDKVRIE 471 + + E I++ Y E L L+T+++ N +YLG++FK T F+ YL++VR + Sbjct: 378 KKYSESVSQAVERIEQGYLEELNLKTVADELHLNPSYLGQIFKKETKRSFSQYLNQVRTK 437 Query: 472 KAKEFLA-QGMKVYEVAEKVGYMNSDYFNAKFRKYVGTSPSSFRK 515 A++ L + E++EKVG+ N++YF+ F+K G +P FR+ Sbjct: 438 HAQKLLLYTDDTINEISEKVGFNNTNYFSKMFKKLNGITPKEFRE 482 >ref|NP_241659.1| two-component sensor response regulator [Bacillus halodurans] pir||A83749 two-component sensor response regulator BH0793 [imported] - Bacillus halodurans (strain C-125) dbj|BAB04512.1| two-component sensor response regulator [Bacillus halodurans] Length = 508 Score = 117 bits (294), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 57/125 (45%), Positives = 84/125 (67%) Query: 2 MIKVLIVDDEPKLREGLRALIPWGQLGFTVVATAANGLQALEKYHIHDPELIVVDIRMPG 61 MI+V++VDDEP + EGL+ LI WGQLG+ +VATA NG++ALE +L++ DI+MP Sbjct: 1 MIRVMLVDDEPLILEGLKHLIDWGQLGYEIVATARNGVEALEIAKYVSFDLLITDIKMPE 60 Query: 62 MDGLELIGELRNEGSTSHVLILSGHADFDYAKRAIGYRIDGYLLKPVDEEEMISLLKELR 121 GLELI L T ++LSG +F + K+ + I+ YLLKP++E+E+IS L ++ Sbjct: 61 KTGLELIAALNEREKTIRSIVLSGFQEFHFVKQGLTLGIENYLLKPINEKELISTLSHVK 120 Query: 122 ETIDR 126 E I+ Sbjct: 121 EKINH 125 Score = 73.2 bits (178), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 33/99 (33%), Positives = 62/99 (62%), Gaps = 1/99 (1%) Query: 418 IKKITELIQRRYNENLKLETLSELFSYNSAYLGKMFKNTTGEYFNTYLDKVRIEKAKEFL 477 I+ + + I + ++++L L+TL F N YLG++F+ G F YL+++RI++AK+ L Sbjct: 405 IQTVLQHIHQHFSQDLSLKTLGHSFHINPIYLGQLFQREVGCSFTKYLNQLRIDRAKKLL 464 Query: 478 AQGM-KVYEVAEKVGYMNSDYFNAKFRKYVGTSPSSFRK 515 + ++ +KVGY ++ YF +F+KY +P+ +RK Sbjct: 465 LNSYDRAGQIGKKVGYGDATYFYKQFKKYEAMTPTEWRK 503 >ref|NP_388577.1| similar to two-component response regulator [YesM] [Bacillus subtilis] pir||E69796 two-component response regulator [YesM] homolog yesN - Bacillus subtilis emb|CAB12515.1| yesN [Bacillus subtilis subsp. subtilis str. 168] Length = 368 Score = 109 bits (273), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 50/127 (39%), Positives = 82/127 (64%) Query: 2 MIKVLIVDDEPKLREGLRALIPWGQLGFTVVATAANGLQALEKYHIHDPELIVVDIRMPG 61 M K+L+ DDE + +G+ +I W LG +++ A NG +A EK P +++ D++MPG Sbjct: 1 MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKIVHKQPHIVITDVKMPG 60 Query: 62 MDGLELIGELRNEGSTSHVLILSGHADFDYAKRAIGYRIDGYLLKPVDEEEMISLLKELR 121 MDGLELI ++ + ++LSG +F+YAK A+ Y + YLLKP +E+++IS L+E+ Sbjct: 61 MDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHYLLKPCNEQQIISSLEEII 120 Query: 122 ETIDRED 128 + R+D Sbjct: 121 AELKRQD 127 Score = 67.8 bits (164), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 40/105 (38%), Positives = 63/105 (60%), Gaps = 5/105 (4%) Query: 418 IKKITELIQRRY-NENLKLETLS-ELFSYNSAYLGKMFKNTTGEYFNTYLDKVRIEKAKE 475 I K+ LI N NL L+ + ++ N YLGK+FK TGE F+ Y+ +VR+E A + Sbjct: 258 ISKMIRLIADELGNPNLSLKWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMK 317 Query: 476 FLA--QGMKVYEVAEKVGYM-NSDYFNAKFRKYVGTSPSSFRKNK 517 + + + V E+AE++G+ N YF+ F+KY G +PS FR+ + Sbjct: 318 QMKIRRDVSVSEIAEEIGFGDNPKYFSLVFKKYTGLTPSEFRRKQ 362 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.318 0.137 0.388 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 743,680,753 Number of extensions: 31051075 Number of successful extensions: 121810 Number of sequences better than 1.0e-05: 2279 Number of HSP's gapped: 123796 Number of HSP's successfully gapped: 2329 Length of query: 517 Length of database: 757,237,578 Length adjustment: 130 Effective length of query: 387 Effective length of database: 404,274,708 Effective search space: 156454311996 Effective search space used: 156454311996 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 128 (53.9 bits)