BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0078.0008.p (608 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,715,099 sequences; 757,237,578 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_563004.1| two-component sensor histidine kinase [Clostrid... 266 1e-69 ref|NP_241658.1| two-component sensor histidine kinase [Bacillus... 264 6e-69 ref|NP_815880.1| sensor histidine kinase [Enterococcus faecalis ... 199 2e-49 ref|NP_471453.1| similar to two-component sensor histidine kinas... 189 2e-46 ref|ZP_00036695.1| COG2972: Predicted signal transduction protei... 188 3e-46 >ref|NP_563004.1| two-component sensor histidine kinase [Clostridium perfringens] dbj|BAB81794.1| two-component sensor histidine kinase [Clostridium perfringens str. 13] Length = 578 Score = 266 bits (680), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 175/594 (29%), Positives = 321/594 (54%), Gaps = 27/594 (4%) Query: 10 KHLKNNLFMKIILIFSIIAVVTTITFSYLMFLLMSQSVVQRQ-LEIQKRTVESVNDYMQH 68 K K+NL+ ++ + ++I+ +++ ++ + FL + ++R L + + ++ VN+ +++ Sbjct: 2 KFSKSNLYKRLFITYTIV-ILSVVSILCIYFLSKTSEEIKRNNLYLNDKILQDVNETLEY 60 Query: 69 KYNAVQTMMRDVYRDSELTANTSYLLEHPYQDYVTYRLDRYLNETSTTTDSVQ-FFRNQL 127 + + +M +Y D + L DY+ +LD Y + ++ F ++ Sbjct: 61 NSSTSRRIMNMLYEDDFRLNDVIKYLNSDLVDYIKGKLDYYSASDKLYYNGIESFVKSSF 120 Query: 128 EDDPDIRRLLLYSSVKQQLYVFNDRENFNIISTNAAHSLVPDALYLEEASSVTLPNIWVR 187 + + ++ + S + ++ VFN + N+ L D +E A I+ + Sbjct: 121 QLNNFLKSISFISYSRNEISVFNRKGEIKTYPFNSNELL--DKKDIEYA-------IYNK 171 Query: 188 KTISLSDSPMFSIRVPINDKQSLRNIGQLLVFYDADHIWKSMGDYKDDFKGDIIVLSADN 247 IS+ + I D SL+ G L+ YD I + YKD ++++L+ + Sbjct: 172 NEISIINE--------IRDAASLKPEGMLMTTYDVGVISDVIKKYKDT-NSEVLILNKEG 222 Query: 248 DVLFDSSGTFYGKKYPYPEQIEAIYADGEKVNGMLITKLTHTQGGFTVLSAVPERELAAT 307 VL+DS + + YPY ++++ + + + L G ++S V + AT Sbjct: 223 MVLYDSENKYDYEYYPYFDKLKVGRHEILLEDSYYVDILPDNNG---LMSVVRIKVSNAT 279 Query: 308 YRGLRNMIVIICLICILFAVITPSLFIS--NFATRAHNIIRFTRKVKNGDLDARIADVKE 365 L + + LF + L+I N ++R +++ KV+ GD+D I K+ Sbjct: 280 KVPLLFKVSAFLVSLFLFIIAECVLYIKFKNLSSRMDSLVLAMEKVEKGDIDVHIPLSKD 339 Query: 366 -DELGQISKSFNDMLDELNLYIDRVFKAEIKQKHSEISALEARVNPHFLYNTLEVIRMRA 424 DE+ I+ +FN M ++LN +I + + AE++Q+ +EI AL+ ++NPHFLYNTLE IRM+A Sbjct: 340 RDEITFIADNFNKMCEKLNDHIRKSYLAELRQREAEIVALQNQINPHFLYNTLESIRMKA 399 Query: 425 ISQGAADVGEMIYSLSVLFKSYVHPKAKHTMKDELEACRLYLELFRIRYKDKFSYELHCP 484 I G +VG+M+YSL+ LF+S V ++ E++ C YLELF+ RY +KF +++ C Sbjct: 400 ICNGDKEVGKMLYSLAFLFRSQVKGNLIVSIDQEIKYCNKYLELFKFRYDEKFKFKIECE 459 Query: 485 KELEGRVVLKMSLQPIVENYILHGMRTDRSDNHISIHLAKEGVILRAVVTDNGRGIKQER 544 ++L + ++K +LQP++ENY +HG+R +R DN + I++ K + V DNGRGI +E+ Sbjct: 460 EDLYDKGIVKFTLQPLIENYFVHGIRLERDDNELKIYIYKHLEDIVVEVIDNGRGIPKEK 519 Query: 545 LEQIQHDLLDKDSSSESFGLRSINERMKLLYGEPHGLAVDSEEGKGTTVTVCFP 598 L+ I + + D S +S G+ +++ER+K+ YGEP+GL V SEE KGT + + FP Sbjct: 520 LDDINRRIRECDHSGKSIGMLNVHERIKIKYGEPYGLTVTSEENKGTNMILKFP 573 >ref|NP_241658.1| two-component sensor histidine kinase [Bacillus halodurans] pir||H83748 two-component sensor histidine kinase BH0792 [imported] - Bacillus halodurans (strain C-125) dbj|BAB04511.1| two-component sensor histidine kinase [Bacillus halodurans] Length = 587 Score = 264 bits (674), Expect = 6e-69, Method: Compositional matrix adjust. Identities = 171/599 (28%), Positives = 321/599 (53%), Gaps = 44/599 (7%) Query: 10 KHLKNNLFMKIILIFSIIAVVTTITFSYLMFLL---MSQSVVQRQLEIQKRTVESVNDYM 66 + L + +F ++ +S I +T ++L L S+ ++QR+++ Q + + + Sbjct: 8 RKLSSRMFYRVFFTYSTIIF---LTMAFLFVFLSDHYSEFIIQREVDKQATAINQIKSEI 64 Query: 67 QHKYNAVQTMMRDVYRDSELTANTSYLLEHPYQDYVTYRLDRYLNETSTTTDSVQFF-RN 125 + K+ VQ + +YR+ L + ++ L+H YQ Y+ YRLD+Y +S + + +N Sbjct: 65 EKKHTFVQQGVYQLYREKHLIEDLAFALQHDYQQYMGYRLDKYSRSSSFVPYNFDIYVKN 124 Query: 126 QLEDDPDIRRLLLYSSV--KQQLYVFNDRENFNIISTNAAHSLVPDALYLEEASSVTLPN 183 D DI L + + Q Y++N + L ++ + +E Sbjct: 125 YFSRDSDIVALQVRNETLGTQYHYLYN-------------YGLWKESDFYDEEE------ 165 Query: 184 IWVRKTISLSDSPMFSIRVPINDKQSLRNIGQLLVFYDADHIWKSMGDYKDDFKGDIIVL 243 + + D+ F++ IND SL +G L V++ HI + + D KG ++ Sbjct: 166 ----RDLYGKDNDFFTLEEQINDPISLERLGTLTVYFTFHHIDRLLTYNGDPMKGSYYII 221 Query: 244 SADNDVLFDSSGTFYGKKYPYPEQIEAI-YADGEKV--NGMLITKLTHTQGGFTVLSAVP 300 + +V++ YG E ++ I Y +++ N LI GF V S VP Sbjct: 222 DEELNVVYS-----YGD--VLDEALKEIDYRATQQLVNNRYLIQSSIEPSTGFMVASIVP 274 Query: 301 ERELAATYRGLRNMIVIICLICILFAVITPSLFISNFATRAHNIIRFTRKVKNGDLDARI 360 EL+ + M ++I L+ ++ ++ P + + + TR +++++ ++V++G L RI Sbjct: 275 RSELSQLFHYKITMFLLILLLTVV-SIALPYVSLRGYLTRVNDLVQTMKEVQSGQLSVRI 333 Query: 361 ADVK-EDELGQISKSFNDMLDELNLYIDRVFKAEIKQKHSEISALEARVNPHFLYNTLEV 419 +D+L IS +FN+ LDEL YI++V+ +++KQ +E++ L++++NPHFLYNTLE Sbjct: 334 ETGNVDDDLAMISNTFNETLDELEDYIEKVYFSKLKQTEAELANLQSQINPHFLYNTLEA 393 Query: 420 IRMRAISQGAADVGEMIYSLSVLFKSYVHPKAKHTMKDELEACRLYLELFRIRYKDKFSY 479 IRM+++S+G +MI LS LF+ + T+ DEL+ Y+ELF IR+ ++ ++ Sbjct: 394 IRMKSLSEGGRTTAKMIVQLSYLFRYSLKSADLVTIGDELQHVEQYVELFNIRFPNQLTF 453 Query: 480 ELHCPKELEGRVVLKMSLQPIVENYILHGMRTDRSDNHISIHLAKEGVILRAVVTDNGRG 539 ++ ++ + VV LQP++EN+++HG + +R DN I+I + ++ L+ + DNG+G Sbjct: 454 QVAVEEKHKHYVVPPFILQPLIENFLIHGFKRERDDNQINIIIQEKEQTLQIQIMDNGKG 513 Query: 540 IKQERLEQIQHDLLDKDSSSESFGLRSINERMKLLYGEPHGLAVDSEEGKGTTVTVCFP 598 I ++++E+I L ++SS S GL ++N+R++L YGE G++V SE T VT+ P Sbjct: 514 IPRKKVEEINERLSMTENSSHSIGLFNVNQRLRLRYGERFGVSVQSEPDVCTIVTIRTP 572 >ref|NP_815880.1| sensor histidine kinase [Enterococcus faecalis V583] gb|AAO81950.1| sensor histidine kinase [Enterococcus faecalis V583] Length = 570 Score = 199 bits (505), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 94/263 (35%), Positives = 168/263 (63%), Gaps = 2/263 (0%) Query: 337 FATRAHNIIRFTRKVKNGDLDARI-ADVKEDELGQISKSFNDMLDELNLYIDRVFKAEIK 395 ++ + I+ TR + +G+L RI + ++EL I+ + N M+D L+ YI ++ EIK Sbjct: 306 YSQQVQLILEATRAIGDGNLKERIDTNQVQEELNDIASAINFMVDSLDQYIHDIYTLEIK 365 Query: 396 QKHSEISALEARVNPHFLYNTLEVIRMRAISQGAADVGEMIYSLSVLFKSYVHPKAKHTM 455 Q+ + + AL++++NPHFLYNTLE IRM A+S+ ++ +++Y+ S L ++ ++ + T+ Sbjct: 366 QRDAHMRALQSQINPHFLYNTLEYIRMYALSRQQEELADVVYAFSTLLRNNINQEKTTTL 425 Query: 456 KDELEACRLYLELFRIRYKDKFSYELHCPKELEGRVVLKMSLQPIVENYILHGMRTDRSD 515 +E+ C Y+ L+++RY D+F+Y+ + + + K +QP+VENY +HG+ R D Sbjct: 426 AEEISFCEKYVYLYQMRYPDQFAYKFEIEETIADVEIPKFIIQPLVENYFVHGIDYQRQD 485 Query: 516 NHISIHLAKEGVILRAVVTDNGRGIKQERLEQIQHDLLDKDSSSE-SFGLRSINERMKLL 574 N I +H +EG + V DNG+GI RLE+I+ L + +E S GLR+++ER++ Sbjct: 486 NAIKVHAYREGEKIIVAVVDNGKGITANRLEEIRERLNQTEIDTEQSIGLRNVHERLQRF 545 Query: 575 YGEPHGLAVDSEEGKGTTVTVCF 597 +GE +GL ++ +EG+GTT+ + F Sbjct: 546 FGESYGLTIEGKEGEGTTIRLSF 568 >ref|NP_471453.1| similar to two-component sensor histidine kinase [Listeria innocua] pir||AE1697 two-component sensor histidine kinase homolog lin2119 [imported] - Listeria innocua (strain Clip11262) emb|CAC97349.1| lin2119 [Listeria innocua] Length = 577 Score = 189 bits (480), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 147/594 (24%), Positives = 284/594 (47%), Gaps = 44/594 (7%) Query: 16 LFMKIILIFSIIAVVTTITFSYLMFLLMS-------QSVVQRQLEIQKRTVESVNDYMQH 68 +F +++LIFS+ ++ T S L+F + + +QR I + +E++ + Sbjct: 10 VFKRMLLIFSLTSLFTV---SLLLFFIYKYYTNIQLDTNLQRAETIASKQLEALTE---- 62 Query: 69 KYNAVQTMMRDVYRDSELTANTSYLLEHPYQDYVTYRLDRYLNETS-TTTDSVQFFRNQL 127 K A+ ++ +D+YR+S+L + + + Y Y +D Y + + D + ++ Sbjct: 63 KQKALISLTQDIYRNSDLMQDVQIAMTNDYGSYTEQNIDNYFKSKNFYSVDMQTYLQSYF 122 Query: 128 EDDPDIRRLLLYSSVKQQLYVFNDR--ENFNIISTNAAHSLVPDALYLEEASSVTLPNIW 185 D DI L L S Y F R E + T ++ A ++ + T+ N Sbjct: 123 SYDEDIIALQLISDDGSYSYTFPSRYREWKETVDTYGEENIASQAS--KQGNFYTIENKI 180 Query: 186 VRKTISLSDSPMFSIRVPINDKQSLRNIGQLLVFYDADHIWKSMGDYKDDFKGDIIVLSA 245 V ++ PIND +L+ +G LL++ D + K + D+K I ++ Sbjct: 181 V-------------VKQPINDPSTLKQMGYLLLYIDPTFLNKWI---TKDYKNSIFQINN 224 Query: 246 DNDVLFDSSGTFYGKKYPYPEQIEAIYADGEKVNGMLITKLTHTQGGFTVLSAVPERELA 305 S+ K+ PE+ + D +K+ T T L V + Sbjct: 225 TKGAELYSNHP--AKQITPPEKQGWMNVDNKKIYFQKTEDETTGLKNNTFLYRVTDDSAP 282 Query: 306 ATYRGLRNMIVIICLICILFAVITPSLFISNFATRAHNIIRFTRKVKNGDLDARI-ADVK 364 + + I L+ ++F++ + ++ R II +V+NG LDA++ D Sbjct: 283 L----IELTLFGIGLLLVIFSISVNFVISRRYSKRILTIIGGMNRVENGTLDAKLPVDNN 338 Query: 365 EDELGQISKSFNDMLDELNLYIDRVFKAEIKQKHSEISALEARVNPHFLYNTLEVIRMRA 424 DEL IS+ FN M + L+ Y+ +V+ E++++ + + AL+ ++ PHFLYN+LE IRM A Sbjct: 339 GDELTMISERFNHMTENLDAYVKKVYSLEMEEQKARLKALQGQMQPHFLYNSLEAIRMNA 398 Query: 425 ISQGAADVGEMIYSLSVLFKSYVHPKAKHTMKDELEACRLYLELFRIRYKDKFSYELHCP 484 +GA + +MIY L+ L + + + T+ +E+ + Y+ +R++ E+H Sbjct: 399 RVEGAKETSDMIYQLATLLRYTANHREITTLGEEINYVKQYVRFMEMRHEQPIKLEIHIE 458 Query: 485 KELEGRVVLKMSLQPIVENYILHGMRTDRSDNHISIHLAKEGVILRAVVTDNGRGIKQER 544 K + + +LQP++EN+ + + ++ ++I + E L+ + DNG+G+ E+ Sbjct: 459 KRFNHTHIPRFALQPLIENFFKYAYKENQHP-VVTITVTAENNNLQFQIKDNGKGMDAEK 517 Query: 545 LEQIQHDLLDKDSSSESFGLRSINERMKLLYGEPHGLAVDSEEGKGTTVTVCFP 598 L+++Q + K +S GL ++N+R++LLYGE + L + S+ +GT + P Sbjct: 518 LKEVQATIESKAETSH-IGLANLNKRLQLLYGEAYSLTITSKPNEGTIILFQVP 570 >ref|ZP_00036695.1| COG2972: Predicted signal transduction protein with a C-terminal ATPase domain [Enterococcus faecium] Length = 574 Score = 188 bits (478), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 93/249 (37%), Positives = 165/249 (66%), Gaps = 4/249 (1%) Query: 354 GDLDARIADVK--EDELGQISKSFNDMLDELNLYIDRVFKAEIKQKHSEISALEARVNPH 411 G+L+ RI D+ E EL ++S N+MLD +N +++ ++K EIKQ+ + + AL+A++NPH Sbjct: 326 GNLETRI-DITNTEYELKELSIGINEMLDSINQFVEDIYKLEIKQQDAHMRALQAQINPH 384 Query: 412 FLYNTLEVIRMRAISQGAADVGEMIYSLSVLFKSYVHPKAKHTMKDELEACRLYLELFRI 471 FLYNTLE IRM AIS+G+ ++ +++Y+ S L ++ + + T+K+EL+ C Y+ L+++ Sbjct: 385 FLYNTLEYIRMYAISEGSEELADVVYAFSALLRNNTNQEKTITLKEELDFCEKYVYLYQM 444 Query: 472 RYKDKFSYELHCPKELEGRVVLKMSLQPIVENYILHGMRTDRSDNHISIHLAKEGVILRA 531 RY ++ +Y +LE V K +QP+VENY HG+ R DN +S+ + +EG +R Sbjct: 445 RYPNRVAYHFMIDPDLEKIEVPKFVIQPLVENYFKHGIDFTRFDNALSVKVLQEGKRVRI 504 Query: 532 VVTDNGRGIKQERLEQIQHDLLD-KDSSSESFGLRSINERMKLLYGEPHGLAVDSEEGKG 590 ++ DNG+G+ ++RL+QI+ L K S GL+++NER++ +G + +++++ E G Sbjct: 505 IIKDNGKGMTEKRLKQIEEKLSHPKVELHGSIGLQNVNERLRASFGSSYYMSLENNETGG 564 Query: 591 TTVTVCFPD 599 TV++ F + Sbjct: 565 LTVSITFKE 573 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF Posted date: Mar 24, 2004 1:53 AM Number of letters in database: 757,237,578 Number of sequences in database: 2,715,099 Lambda K H 0.321 0.137 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 2715099 Number of Hits to DB: 863,624,830 Number of extensions: 35801205 Number of successful extensions: 101533 Number of sequences better than 1.0e-05: 172 Number of HSP's gapped: 101425 Number of HSP's successfully gapped: 173 Length of query: 608 Length of database: 757,237,578 Length adjustment: 132 Effective length of query: 476 Effective length of database: 398,844,510 Effective search space: 189849986760 Effective search space used: 189849986760 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 129 (54.3 bits)