BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0599.0111.p (391 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2315 [V] COG1680 Beta-lactamase class C and other penicillin b... 407 e-113 MT1414 [V] COG1680 Beta-lactamase class C and other penicillin b... 142 1e-33 CC1567 [V] COG1680 Beta-lactamase class C and other penicillin b... 138 1e-32 Rv1367c [V] COG1680 Beta-lactamase class C and other penicillin ... 133 5e-31 CC1568 [V] COG1680 Beta-lactamase class C and other penicillin b... 129 9e-30 >PA2315 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 407 bits (1045), Expect = e-113, Method: Compositional matrix adjust. Identities = 0/374 (0%), Positives = 0/374 (0%), Gaps = 1/374 (0%) Query: 14 LPERIDKVIDQTLTDKRLAGAVIKVAVDGELIYNRAAGFANRELNQPMREDALFRLASVS 73 + + L L + + A + D+ + + + Sbjct: 12 FSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPAMIAEA 71 Query: 74 KPITSTAALVLVAQGRLQLDDRVDRWLPEFQPRLKNGEHAAITIRHLMTHTAGLTYRFFQ 133 + V Q +D + + + + G+ Sbjct: 72 RSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMP 131 Query: 134 EEG-GSYEQAGVSDGMDQPGITLDENLRRIASAPLLYTPGTQWRYSIATDVLGAVIARVA 192 + +Q A I + Sbjct: 132 DNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQ 191 Query: 193 GTTLSEAIDALVTRPLGMKDTGFLATDPQRLATAYADDVPGLRPLHNPDSLAFMEGTAGF 252 L + ++ + Sbjct: 192 AIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILLAFPRLFIVARRM 251 Query: 253 RLSPGRALDPAAYHSGGAGMVGSTGDFLHLLETLRKGGAPLLPEPLVREMTTNQIGDLHM 312 Sbjct: 252 311 Query: 313 PFWPGRGFGLGITVLKDPVAADTAESPGTWRMGGTYGHSWFVDPEQRLSVAAFTNTALEG 372 Sbjct: 312 371 Query: 373 MSGPFTIDLCNAVY 386 Sbjct: 372 385 >MT1414 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 142 bits (357), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 0/383 (0%), Positives = 0/383 (0%), Gaps = 59/383 (15%) Query: 9 INLDRLPERIDKVIDQTLTDKRLAGAVIKVAVDGELIYNRAAGFANRELNQPMREDALFR 68 ++ + +++ A ++ + Y G +++ Sbjct: 1 MSDWNPSLYLHFSAERSR----PAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAA 56 Query: 69 LASVSKPITSTAALVLVAQGRLQLDDRVDRWLPEFQPRLKNGEHA-----------AITI 117 + + A A Q + R Q +A + Sbjct: 57 RITGIDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHL 116 Query: 118 RHLMTHTAGLTYRFFQEE--GGSYEQAGVSDGMDQPGITLDENLRRIASAPLLYTPGTQW 175 L+ L + V+ + R ++ Sbjct: 117 VSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQ-------NYPDRGREPLAGVHAYYDIL 169 Query: 176 RYSIATDVLGAVIARVAGTTLSEAIDALVTRPLGMKDTGF-LATDPQ-RLATAY-ADDVP 232 + + + ID + L + ++ Sbjct: 170 SEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQY 229 Query: 233 GLRPLHNPDSLAFMEGTAGFRLSPGRALDPAAYHSGGAGMVGSTGDFLHLLETLRKGGA- 291 L+ N Sbjct: 230 PLQ--EN-------------GQILLA- 273 Query: 292 ----PLLPEPLVREMTTNQIGD-------LHMPFWPGRGFGLGITVLKDPVAADTAESP- 339 Sbjct: 274 - 332 Query: 340 --GTWRMGGTYGHSWFVDPEQRL 360 Sbjct: 333 355 >CC1567 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 138 bits (348), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 0/385 (0%), Positives = 0/385 (0%), Gaps = 56/385 (14%) Query: 16 ERIDKVID--QTLTDK-RLAGAVIKVAVDGELIYNRAAGFANRELN-QPMREDALFRLAS 71 + + A+ + + L + + + Sbjct: 72 RSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPD--HYELFPHLVSLLNPQGVLAVQ 129 Query: 72 VSKPITSTAALVLVAQGRLQLDDRVDRWLPEF-------------QPRLKNGEHAAITIR 118 + +++ Q R + + + + Sbjct: 130 MPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYH-QMP 188 Query: 119 HLMTHTAGLTYRFFQEEGGSYEQAGVSDGMDQPGITLDENLRRIASAPLLYTPGTQWRYS 178 +T + ++ + + + E + + + Sbjct: 189 SHQAIIDWVTATGLRPWLQDLTESEQQLFLKR-YHQMLEEQYPLQENGQILLAFPRLFIV 247 Query: 179 IATDVLGAVIARVAGTTLSEAIDALVTRPLGMKDTGFLATDPQ--RLATAYADDVPGLRP 236 Sbjct: 248 ------ 301 Query: 237 LHNPDSLAFMEGTAGFRLSPGRALDPAAYHSGGAGMVGSTGDFLHLLE-TLRKG---GAP 292 Sbjct: 302 ------ 355 Query: 293 LLPEPLVREMTTNQIGDLHM-----------------PFWPGRGFGLGITVLKDPVAADT 335 Sbjct: 356 415 Query: 336 AESPGTWRMGGTYGHSWFVDPEQRL 360 Sbjct: 416 440 >Rv1367c [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 133 bits (335), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 0/348 (0%), Positives = 0/348 (0%), Gaps = 53/348 (15%) Query: 43 ELIYNRAAGFANRELNQPMREDALFRLASVSKPITSTAALVLVAQGRLQLDDRVDRWLPE 102 L + +A + + R + L+ Q P Sbjct: 7 SLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPA 66 Query: 103 FQPRLKNGEHA-----------AITIRHLMTHTAGLTYRFFQEE--GGSYEQAGVSDGMD 149 ++ + G+ Sbjct: 67 MIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNPQGV- 125 Query: 150 QPGITLDENLRRIASAPLLYTPGTQWRYSIATDVLGAVIARVAGTTLSEAIDALVTRPLG 209 + + + G +A + Sbjct: 126 ------LAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIW 179 Query: 210 MKDTGF-LATDPQ-RLATAY-ADDVPGLRPLHNPDSLAFMEGTAGFRLSPGRALDPAAYH 266 + + + Sbjct: 180 RTTYYHQMPSHQAIIDWVTATGLRPWLQD--LT-------------ESEQQL-FLKRYHQ 223 Query: 267 SGGAGMVGSTGDFLHLLETL----RKGGAPLLPEPLVREMTTNQIGD-------LHMPFW 315 + L Sbjct: 224 MLEEQYPLQENGQILLAFPRLFIV 283 Query: 316 PGRGFGLGITVLKDPVAADTAESP---GTWRMGGTYGHSWFVDPEQRL 360 Sbjct: 284 331 >CC1568 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 129 bits (324), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 0/363 (0%), Positives = 0/363 (0%), Gaps = 44/363 (12%) Query: 24 QTLTDK-RLAGAVIKVAVDGELIYNRAAGFANRELNQPMREDALFRLASVSKPITSTAAL 82 + A+I A D +F AS+ Sbjct: 55 AARITGIDSSPAMIAEARSALPDCQFVEADIRNW-QPVQALDLIFANASLQWLPDHYELF 113 Query: 83 VLVAQGRLQLDDRVDRWLPEF-QPRLKNGEHA-----------AITIRHLMTHTAGLTYR 130 + + + +P + Sbjct: 114 PHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAG 173 Query: 131 FFQEEGGSYEQAGVSDGMDQPGITLDENLRRIASAPLLYTPGTQWRYSIATDVLGAVIAR 190 + + + L ++ + + Sbjct: 174 CEVDIWRTTYYHQMPSHQAIID----WVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQY 229 Query: 191 VAGTTLSEAIDALVTRPLGMKDTGFL--ATDPQRLATAYADDVPGLRPLHNPDSLAFMEG 248 Sbjct: 230 - 288 Query: 249 TAGFRLSPGRALDPAAYHSGGAGMVGSTGDFLHLLETLRKG----GAPLLPEPLVREMTT 304 Sbjct: 289 ----------- 337 Query: 305 NQIGDLHM-----PFWP--GRGFGLGITVLKDPVAADTAESPGTWRMGGTYGHSWFVDPE 357 Sbjct: 338 - 396 Query: 358 QRL 360 Sbjct: 397 399 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.319 0.137 0.410 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 31,029,287 Number of extensions: 1387125 Number of successful extensions: 2451 Number of sequences better than 1.0e-05: 52 Number of HSP's gapped: 2386 Number of HSP's successfully gapped: 52 Length of query: 391 Length of database: 38,378,431 Length adjustment: 108 Effective length of query: 283 Effective length of database: 25,922,359 Effective search space: 7336027597 Effective search space used: 7336027597 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 117 (49.7 bits)