BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0586.0002.p (410 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_ymxG [R] COG0612 Predicted Zn-dependent peptidases 425 e-119 BH2405 [R] COG0612 Predicted Zn-dependent peptidases 416 e-116 BMEI1451 [R] COG0612 Predicted Zn-dependent peptidases 278 2e-74 mll7516 [R] COG0612 Predicted Zn-dependent peptidases 270 3e-72 CC3398 [R] COG0612 Predicted Zn-dependent peptidases 202 1e-51 >BS_ymxG [R] COG0612 Predicted Zn-dependent peptidases Length = 409 Score = 425 bits (1093), Expect = e-119, Method: Compositional matrix adjust. Identities = 213/389 (54%), Positives = 278/389 (71%) Query: 1 VVTEKIPTGRSVSFGIWVKTGSRNETPQNNGISHFIEHMLFKGTDRYSAKDIAEQFDAIG 60 +V E PT RSV+ G+W+ TGSR+ETP+ NGISHF+EHM FKGT SA++IAE FD IG Sbjct: 13 IVLENNPTVRSVAIGVWIGTGSRHETPEINGISHFLEHMFFKGTSTKSAREIAESFDRIG 72 Query: 61 GNVNAFTSKEYTCYYAKVLDEHLPIAVDVLADMFFRSRMDAEELAKEKNVILEEIAMCED 120 G VNAFTSKEYTCYYAKVLDEH A+DVLADMFF S D EL KEKNV+ EEI M ED Sbjct: 73 GQVNAFTSKEYTCYYAKVLDEHANYALDVLADMFFHSTFDENELKKEKNVVYEEIKMYED 132 Query: 121 TPDDLVHDLMCAAAYGEHPLAYSILGLKERLQEMTPDDLRDYMKAQYTIENTVISVAGNI 180 PDD+VHDL+ A YG H L Y ILG +E L D LR YM YT + VISVAGNI Sbjct: 133 APDDIVHDLLSKATYGNHSLGYPILGTEETLASFNGDSLRQYMHDYYTPDRVVISVAGNI 192 Query: 181 NDGLEELLEKHFGSFQNHGESAALAAPDFHGGLLFHRKKTEQNHICLSLPGVQSGGPLQY 240 +D + +EK FGS++ G++ L P+FH L +K+TEQ H+CL G++ G Y Sbjct: 193 SDSFIKDVEKWFGSYEAKGKATGLEKPEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIY 252 Query: 241 PMVLLNNAIGGGMSSRMFQEIREKRGLAYSVYSYHSSQADSGLFTVYAGTAPKQTKEVTE 300 +++LNN +GG MSSR+FQ++RE +GLAYSVYSYHSS DSG+ T+Y GT Q ++++E Sbjct: 253 DLIVLNNVLGGSMSSRLFQDVREDKGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSE 312 Query: 301 LIKEMMHELAVKGLSDDELRKGKEQLKGSLILSLESTSSRMNRIGKNELMLGRHDTLDDM 360 I+E + L G++ EL KEQ+KGSL+LSLEST+S+M+R GKNEL+LG+H TLD++ Sbjct: 313 TIQETLATLKRDGITSKELENSKEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEI 372 Query: 361 IAKIQQVSMDDVNQLLDHMFAQPLAVAMV 389 I ++ V+++ VN L +F + A+A++ Sbjct: 373 INELNAVNLERVNGLARQLFTEDYALALI 401 >BH2405 [R] COG0612 Predicted Zn-dependent peptidases Length = 413 Score = 416 bits (1069), Expect = e-116, Method: Compositional matrix adjust. Identities = 208/391 (53%), Positives = 271/391 (69%) Query: 1 VVTEKIPTGRSVSFGIWVKTGSRNETPQNNGISHFIEHMLFKGTDRYSAKDIAEQFDAIG 60 ++TEK+ T RSVS GIWV TGSR E+ + NGISHF+EHM FKGT+ SA++IAE FD+IG Sbjct: 13 IITEKMSTVRSVSIGIWVGTGSRYESAEENGISHFLEHMFFKGTNTRSAQEIAEFFDSIG 72 Query: 61 GNVNAFTSKEYTCYYAKVLDEHLPIAVDVLADMFFRSRMDAEELAKEKNVILEEIAMCED 120 G VNAFTSKEYTCYYAKVLD+H A+D L+DMFF S EEL KE+ V+ EEI M +D Sbjct: 73 GQVNAFTSKEYTCYYAKVLDDHAGQAIDTLSDMFFHSTFQKEELEKERKVVFEEIKMVDD 132 Query: 121 TPDDLVHDLMCAAAYGEHPLAYSILGLKERLQEMTPDDLRDYMKAQYTIENTVISVAGNI 180 TPDD+VHDL+ +A YG+H L Y ILG E L LR YM YT + VISVAGN+ Sbjct: 133 TPDDIVHDLLSSATYGKHSLGYPILGTVETLNSFNEGMLRHYMDRFYTGDYVVISVAGNV 192 Query: 181 NDGLEELLEKHFGSFQNHGESAALAAPDFHGGLLFHRKKTEQNHICLSLPGVQSGGPLQY 240 +D L + +++ F + + P F + +K+TEQ H+CL PG+ G Y Sbjct: 193 HDELIDKIKETFSQVKPTTYNYQGEKPMFLPNRIVRKKETEQAHLCLGYPGLPIGDKDVY 252 Query: 241 PMVLLNNAIGGGMSSRMFQEIREKRGLAYSVYSYHSSQADSGLFTVYAGTAPKQTKEVTE 300 +VLLNN +GG MSSR+FQ+IREKRGL YSV+SYHSS DSG+ T+YAGT Q ++ Sbjct: 253 ALVLLNNVLGGSMSSRLFQDIREKRGLCYSVFSYHSSFRDSGMLTIYAGTGHDQLDDLVY 312 Query: 301 LIKEMMHELAVKGLSDDELRKGKEQLKGSLILSLESTSSRMNRIGKNELMLGRHDTLDDM 360 I+E LA KGL++ EL GKEQLKGSL+LSLEST+SRM+R GKNEL+L +H +LD+M Sbjct: 313 SIQETTSALAEKGLTEKELENGKEQLKGSLMLSLESTNSRMSRNGKNELLLKKHRSLDEM 372 Query: 361 IAKIQQVSMDDVNQLLDHMFAQPLAVAMVGA 391 I +I V DV++L + + +++++ A Sbjct: 373 IEQINAVQKQDVSRLAKILLSASPSISLINA 403 >BMEI1451 [R] COG0612 Predicted Zn-dependent peptidases Length = 490 Score = 278 bits (710), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 142/381 (37%), Positives = 222/381 (58%), Gaps = 2/381 (0%) Query: 1 VVTEKIPTGRSVSFGIWVKTGSRNETPQNNGISHFIEHMLFKGTDRYSAKDIAEQFDAIG 60 + T+ +P SV+ GIWVK G+RNE P +GI+H +EHM FKGT+ +A IA + +G Sbjct: 74 IATDTMPHVESVALGIWVKAGARNEAPDRHGIAHLLEHMAFKGTENRTAWQIASDIENVG 133 Query: 61 GNVNAFTSKEYTCYYAKVLDEHLPIAVDVLADMFFRSRMDAEELAKEKNVILEEIAMCED 120 G +NA TS E T YYA+VL +P+A+D+L+D+ S+ D EL +EK VI++EI D Sbjct: 134 GEINATTSVETTSYYARVLRNDMPLAIDILSDILTASKFDEGELEREKQVIMQEIGAAHD 193 Query: 121 TPDDLVHDLMCAAAYGEHPLAYSILGLKERLQEMTPDDLRDYMKAQYTIENTVISVAGNI 180 TPDD+V D AY P+ +ILG E + T DDLR YM+ QY+ + V++ AG I Sbjct: 194 TPDDIVFDRFTETAYRHQPIGRAILGEPETVMSFTSDDLRQYMQEQYSADRMVVTAAGGI 253 Query: 181 N-DGLEELLEKHFGSFQNHGESAALAAPDFHGGLLFHRKKTEQNHICLSLPGVQSGGPLQ 239 + D +EK GSF+ H + L + GG ++ + + G Sbjct: 254 DHDEFVREVEKRLGSFRPHNTAPTLDLAHYVGGDFRENRELMDAQVLIGFEGRAYHVRDF 313 Query: 240 YPMVLLNNAIGGGMSSRMFQEIREKRGLAYSVYSYHSSQADSGLFTVYAGTAPKQTKEVT 299 Y LL+ +GGGMSSR+FQE+REKRGL YSVY++H +D+GLF ++A T + E+ Sbjct: 314 YASQLLSMILGGGMSSRLFQEVREKRGLCYSVYAFHWGFSDTGLFGIHAATGRDELVELV 373 Query: 300 ELIKEMMHELAVKGLSDDELRKGKEQLKGSLILSLESTSSRMNRIGKNELMLGRHDTLDD 359 +I + +H+ A + +E+ + + Q + SL++S ES +SR +I + L+ GR + Sbjct: 374 PVIIDELHK-AANSIGIEEVDRARAQYRASLLMSQESAASRAGQIARQFLLYGRPVENSE 432 Query: 360 MIAKIQQVSMDDVNQLLDHMF 380 ++ ++ ++ + + L +F Sbjct: 433 LLDRLSLITPERLTDLAGRLF 453 >mll7516 [R] COG0612 Predicted Zn-dependent peptidases Length = 430 Score = 270 bits (690), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 144/393 (36%), Positives = 228/393 (58%), Gaps = 6/393 (1%) Query: 1 VVTEKIPTGRSVSFGIWVKTGSRNETPQNNGISHFIEHMLFKGTDRYSAKDIAEQFDAIG 60 V TE +P+ SV+ G WVK+G+RNE + +G++H +EHM FKGT R +A +IA + + +G Sbjct: 14 VATETLPSIESVALGAWVKSGARNERDEEHGMAHLLEHMAFKGTKRRTAFEIASEIEDVG 73 Query: 61 GNVNAFTSKEYTCYYAKVLDEHLPIAVDVLADMFFRSRMDAEELAKEKNVILEEIAMCED 120 G +NA TS E T YYA+VL + +P+AVD+LAD+ S D +EL +E++VIL+EI D Sbjct: 74 GEINAATSVETTSYYARVLSDDVPLAVDILADILQESEFDPQELEREQHVILQEIGAAHD 133 Query: 121 TPDDLVHDLMCAAAYGEHPLAYSILGLKERLQEMTPDDLRDYMKAQYTIENTVISVAGNI 180 TPDD+V D A+ + SILG + ++ T L D+++ QY E VI AG+I Sbjct: 134 TPDDIVFDRFTETAFRHQTIGRSILGTPDTVKSFTSKQLHDFIERQYGAERMVIVAAGDI 193 Query: 181 -NDGLEELLEKHFGSFQNHGESAALAAPDFHGGLLFHRKKTEQNHICLSLPGVQSGGPLQ 239 +D +EK G F++ +S + GG + I L G Sbjct: 194 KHDNFVREVEKQLGGFRSKADSTIPQYAQYVGGDFREDRDLMDAQIVLGFEGRAYHVRDF 253 Query: 240 YPMVLLNNAIGGGMSSRMFQEIREKRGLAYSVYSYHSSQADSGLFTVYAGTAPKQTKEVT 299 Y +L+ +GGGMSSR+FQE+REKRGL YSVY++H +D+G+F V+A T ++ Sbjct: 254 YASQVLSMILGGGMSSRLFQEVREKRGLCYSVYAFHWGFSDTGIFGVHAATG---QSDIA 310 Query: 300 ELIKEMMHELAVKG--LSDDELRKGKEQLKGSLILSLESTSSRMNRIGKNELMLGRHDTL 357 EL+ ++ EL G + +EL + + Q + LI+S ES +SR ++I + L+ GR Sbjct: 311 ELVPVIIDELQKAGENILQEELDRARAQYRAGLIMSAESPASRASQIARQLLLFGRPIAK 370 Query: 358 DDMIAKIQQVSMDDVNQLLDHMFAQPLAVAMVG 390 ++++ ++ ++++ + L MF+ + VG Sbjct: 371 EELMERLSALTVERLTDLSSRMFSTKPTLTAVG 403 >CC3398 [R] COG0612 Predicted Zn-dependent peptidases Length = 423 Score = 202 bits (513), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 125/393 (31%), Positives = 199/393 (50%), Gaps = 3/393 (0%) Query: 1 VVTEKIPTGRSVSFGIWVKTGSRNETPQNNGISHFIEHMLFKGTDRYSAKDIAEQFDAIG 60 VV + +P +++ + G+ E P +G SH +EHM+FKG SA+DI E + G Sbjct: 14 VVCDPMPGLETLALSVVAGRGAAYEDPARSGWSHLLEHMVFKGAGSRSARDIVEVIENQG 73 Query: 61 GNVNAFTSKEYTCYYAKVLDEHLPIAVDVLADMFFRSRMDAEELAKEKNVILEEIAMCED 120 G++NA T E T + + L L + +DV+AD+ R +D +L +EK V+ +EIA D Sbjct: 74 GSINAATGYERTSFQVRALKGGLDLGMDVIADLVRRPTLDPADLTREKQVVAQEIAEAAD 133 Query: 121 TPDDLVHDLMCAAAYGEHPLAYSILGLKERLQEMTPDDLRDYMKAQYTIENTVISVAG-N 179 PDD V DL+ A++G+HP+ ILG E + + + L D+ Y + VI+ G Sbjct: 134 APDDYVFDLIQRASWGDHPVGRPILGSDETVNAASVEALSDWRGDLYAADRLVIAATGAV 193 Query: 180 INDGLEELLEKHFGSFQNHGESAALAAPDFHGGLLFHRKKTEQNHICLSLPGVQSGGPLQ 239 L E+ FG + F GG +K EQ H+ LP + Sbjct: 194 EEAELMAAAERAFGDLPATPGVGLAQSAAFVGGPQAEARKLEQAHLVFMLPACGAREDDY 253 Query: 240 YPMVLLNNAIGGGMSSRMFQEIREKRGLAYSVYSYHSSQADSGLFTVYAGTAPKQTKEVT 299 + + + +GGGMSSR+FQE REKRGLAY++ +Y + AD G +YAG A E Sbjct: 254 FALRIFAECLGGGMSSRLFQEAREKRGLAYNIDAYADTYADHGALGIYAGCAASDAVETA 313 Query: 300 ELIKEMMHELAVKGLSDDELRKGKEQLKGSLILSLESTSSRMNRIGKNELMLGRHDTLDD 359 ++ + + +LA + + + EL + K QLK + ++ E SR + L+ R + Sbjct: 314 KVCADELIKLADR-IEEAELARAKAQLKAHMFMAREQPLSRAEQGAGQVLLFDRLYPPAE 372 Query: 360 MIAKIQQVSMDDVNQLLDHMFAQP-LAVAMVGA 391 + ++ V+ DV +L + A A A++GA Sbjct: 373 LAREVDAVTPQDVARLGQRLLAAGRAATAVLGA 405 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.317 0.134 0.378 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 30,118,059 Number of extensions: 1267934 Number of successful extensions: 2987 Number of sequences better than 1.0e-05: 71 Number of HSP's gapped: 2900 Number of HSP's successfully gapped: 76 Length of query: 410 Length of database: 38,378,431 Length adjustment: 109 Effective length of query: 301 Effective length of database: 25,807,025 Effective search space: 7767914525 Effective search space used: 7767914525 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 117 (49.7 bits)