BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0584.0059.p (322 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH0008 [T] COG2206 HD-GYP domain 156 5e-38 BH3794 [T] COG2206 HD-GYP domain 124 2e-28 CAC2620 [T] COG2206 HD-GYP domain 121 1e-27 CAC0277 [T] COG2206 HD-GYP domain 108 2e-23 RSc2515 [T] COG2206 HD-GYP domain 98 2e-20 >BH0008 [T] COG2206 HD-GYP domain Length = 360 Score = 156 bits (394), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 99/310 (31%), Positives = 163/310 (52%), Gaps = 15/310 (4%) Query: 8 KRTVVQREEITILLRHKIEYVDIEPRTASHAE----DSGLGHS----------LNDNFDH 53 ++TV+ E+I L + I+ +++E A+ + D+GLG D + Sbjct: 29 EKTVLTAEDIQTLSKFLIDEIEVENVLANGEKFIPSDNGLGAEAAALMETGDRFKDRYMQ 88 Query: 54 AIQNYESIFLEALAQGTFTQSMVDDTLQPLLETLDTQKDVVSLLLLLERDDIDTYHHSLQ 113 A+ NY+ +F E A V L PL E + +KDV+ L + YHH++ Sbjct: 89 AVANYKKVFQEWAAGTPVEMECVRHILLPLFEEIVEKKDVLLQLHHYSTKEDYLYHHAVS 148 Query: 114 VGLLSYYIAAWMGHSKEERYEISRAGYLHDIGKSQVPLSILNKAGILTPAEEEELKRHTT 173 VGLLS ++ A +G+ K E +I+ AG L D G +++P S+L K G+ T E+ E++ H Sbjct: 149 VGLLSAFLGAKLGYEKGEWLKIALAGALADCGMAKLPTSLLTKNGLYTLKEKHEMRDHPK 208 Query: 174 FGYEIIRGSKMDEKTALVA-LQHHEFEDGTGYPNQILKSGIHPYTEIVTVANIYMGLTTS 232 + Y++++ + + L A LQHHE EDGTGYP + IH Y +I+ VA++Y + + Sbjct: 209 YSYQMLKKRPEIDGSLLSAVLQHHEREDGTGYPLGVRGQKIHFYAQILAVADVYHAMISE 268 Query: 233 RLNQPKQGLVAVLRKVHEMGFGKLNGTVVQALTGHLLPGFVGKNVQLSNGEIGTIVMNNP 292 R + K+ VL + + FGK N +V L L V +V+L+N +G IV +P Sbjct: 269 RKYRKKKSPYMVLEDLAKERFGKFNPRIVHVLVSQLTQLSVRTSVRLTNNRLGEIVFIDP 328 Query: 293 LDMFRPLVKV 302 + RP+V++ Sbjct: 329 MAPTRPMVQL 338 >BH3794 [T] COG2206 HD-GYP domain Length = 231 Score = 124 bits (312), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 80/224 (35%), Positives = 124/224 (55%), Gaps = 9/224 (4%) Query: 102 RDDIDTYHHSLQVGLLSYYIAAWMGHSKEERYEISRAGYLHDIGKSQVPLSILNKAGILT 161 +DD TY H++ V +LS I W+ + E++ LHDIGK ++P +ILNK G LT Sbjct: 7 KDDY-TYRHTVGVSILSRLIGTWLKLDEVILKELTLGAVLHDIGKVEIPDAILNKPGALT 65 Query: 162 PAEEEELKRHTTFGYEIIRGSKMDEKT-ALVALQHHEFEDGTGYPNQILKSGIHPYTEIV 220 E ++ HT GY II+ S + T AL+AL+HHE EDGTGYP Q ++ IH ++I+ Sbjct: 66 KDEYRIIQDHTVKGYRIIQESGIYSDTVALMALEHHEREDGTGYPYQKTRNEIHLLSKIL 125 Query: 221 TVANIYMGLTTSRLNQPKQGLVAVLRKVHEMGFGKLNGTVVQALTGHLLPGFVGKNVQLS 280 VA+++ +T+ R+ + L VL ++ + FGKL + + +G +L+ Sbjct: 126 AVADVFHAMTSDRIYRKGMALYDVLLQMRQDRFGKLEPRITDFFVRRFMEQCIGSKARLN 185 Query: 281 NG---EIGTIVMNNPLDMFRPLVKVDNVFKDLSRERSLSVEEII 321 +G EI I NP+ P+VK + DL R L ++E+I Sbjct: 186 DGSRVEIVFIPYENPIC---PIVKQGTNYIDL-RMSPLYIQELI 225 >CAC2620 [T] COG2206 HD-GYP domain Length = 345 Score = 121 bits (304), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 68/218 (31%), Positives = 117/218 (53%), Gaps = 5/218 (2%) Query: 106 DTYHHSLQVGLLSYYIAAWMGHSKEERYEISRAGYLHDIGKSQVPLSILNKAGILTPAEE 165 + Y HS+ V +S+ + W+G ++EE ++ A LHD GK+Q+ SIL K LTP E Sbjct: 132 NIYRHSVNVAAISFILGKWLGMNEEEINLLTYASLLHDFGKTQLDNSILKKESSLTPEEY 191 Query: 166 EELKRHTTFGYEIIRG-SKMDEKTALVALQHHEFEDGTGYPNQILKSGIHPYTEIVTVAN 224 K H Y +I+ ++ L L HHE DG+GYP I + IH + +I+ +A+ Sbjct: 192 AVYKTHPVIAYHLIKEIPDINASVGLGVLMHHEQIDGSGYPLGIKDNKIHKFAKIIAIAD 251 Query: 225 IYMGLTTSRLNQPKQGLVAVLRKVHEMGFGKLNGTVVQALTGHLLPGFVGKNVQLSNGEI 284 I+ + + N P +GL A + ++ GKL+ + H + ++G++V LS+ Sbjct: 252 IFDKVNSDNTNGPFEGLKA----IKDLSLGKLDCSYSNMFINHAVNYYMGESVTLSDNRS 307 Query: 285 GTIVMNNPLDMFRPLVKVDNVFKDLSRERSLSVEEIIM 322 I+ + ++ +PL+ D+ F DL E+ L V+ +I+ Sbjct: 308 CKIIKLDTENLTKPLLLADDGFLDLKSEKDLYVKSLIV 345 >CAC0277 [T] COG2206 HD-GYP domain Length = 372 Score = 108 bits (269), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 70/221 (31%), Positives = 115/221 (52%), Gaps = 1/221 (0%) Query: 83 LLETLDTQKDVVSLLLLLERDDIDTYHHSLQVGLLSYYIAAWMGHSKEERYEISRAGYLH 142 ++E + +QK+V+ L+ ++ D TY HS+ V ++S I + K E +++ LH Sbjct: 116 IIEEILSQKNVMIGLVDIKSFDDYTYQHSVNVAVISLIIGIKLKFHKYELFDLCIGALLH 175 Query: 143 DIGKSQVPLSILNKAGILTPAEEEELKRHTTFGYEIIRG-SKMDEKTALVALQHHEFEDG 201 D+GK +P ILNK G LT E + +K HT GY+ ++G ++ +++LQHHE G Sbjct: 176 DVGKMFIPSEILNKKGELTEEEFKIMKEHTVRGYDYLKGLYEISVPARIISLQHHERAGG 235 Query: 202 TGYPNQILKSGIHPYTEIVTVANIYMGLTTSRLNQPKQGLVAVLRKVHEMGFGKLNGTVV 261 GYP I + IV VA++Y +T+ R+ + L + K + VV Sbjct: 236 QGYPEGRSGERISILSRIVAVADVYDAMTSDRVYRRAIAPNEALEYIMANSGSKFDYKVV 295 Query: 262 QALTGHLLPGFVGKNVQLSNGEIGTIVMNNPLDMFRPLVKV 302 QA + ++P G V+LSN EIG + + RP +K+ Sbjct: 296 QAFSKSVIPYPEGSIVRLSNNEIGVVTKIHEDFPLRPEIKI 336 >RSc2515 [T] COG2206 HD-GYP domain Length = 402 Score = 97.8 bits (242), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 79/279 (28%), Positives = 128/279 (45%), Gaps = 14/279 (5%) Query: 30 IEPRTASHAEDSGLGHSLNDNFDHAIQNYESIFLEALAQGTFTQSMVDDTLQPLLETLDT 89 I PR A+ A++ + D A+Q ++F EA +++ QPL+E + Sbjct: 86 IAPRPATLADEMRRAARIIDKAGIAVQ---AMFAEA----RMGRTIEARDAQPLVEAISG 138 Query: 90 QKD-----VVSLLLLLERDDIDTYHHSLQVGLLSYYIAAWMGHSKEERYEISRAGYLHDI 144 D +VSL L +D T+ HS+ V L + +G S +E + AG LHDI Sbjct: 139 SVDRHPGALVSLARLKTKDRY-TFLHSVAVCALMVALGRQLGLSDDEVRDAGLAGLLHDI 197 Query: 145 GKSQVPLSILNKAGILTPAEEEELKRHTTFGYEIIRGSKMDEKTAL-VALQHHEFEDGTG 203 GK +P +LNK G LT E + H GY+I+ G AL V L HHE DGTG Sbjct: 198 GKIAIPPEVLNKPGALTTDEFRHVIGHPKAGYDILVGDPSMRDIALDVCLHHHERMDGTG 257 Query: 204 YPNQILKSGIHPYTEIVTVANIYMGLTTSRLNQPKQGLVAVLRKVHEMGFGKLNGTVVQA 263 YP+++ I + + + ++Y +T+ R + ++++ E + V QA Sbjct: 258 YPHKLAGENISLFARMGAICDVYDAVTSDRPYKKAWEAAYAIQRMVEWRGNHFDPMVFQA 317 Query: 264 LTGHLLPGFVGKNVQLSNGEIGTIVMNNPLDMFRPLVKV 302 + G V+L +G + ++ + + P VKV Sbjct: 318 FVKSVGIYPTGSLVRLRSGRLAVVMEHASGALLSPTVKV 356 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.136 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 24,488,529 Number of extensions: 1073078 Number of successful extensions: 1842 Number of sequences better than 1.0e-05: 38 Number of HSP's gapped: 1809 Number of HSP's successfully gapped: 38 Length of query: 322 Length of database: 38,378,431 Length adjustment: 106 Effective length of query: 216 Effective length of database: 26,153,027 Effective search space: 5649053832 Effective search space used: 5649053832 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 116 (49.3 bits)