BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0580.0009.p (506 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin1658 [GEPR] COG0477 Permeases of the major facilitator superf... 213 4e-55 BS_lmrB [GEPR] COG0477 Permeases of the major facilitator superf... 194 2e-49 lin0519 [GEPR] COG0477 Permeases of the major facilitator superf... 179 8e-45 MT0807 [GEPR] COG0477 Permeases of the major facilitator superfa... 177 5e-44 Rv0783c [GEPR] COG0477 Permeases of the major facilitator superf... 166 7e-41 >lin1658 [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 489 Score = 213 bits (543), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 119/405 (29%), Positives = 215/405 (53%), Gaps = 1/405 (0%) Query: 20 LLAIIAGVFMVVLDSTAMNVALSTLVKDFHTELNTLQWVVTGYMLAQASVIPLSGWLSDR 79 L+ ++ G F+ +L+ T MNVAL +++KDF + QW+ TG+ML +IP++ +L +R Sbjct: 14 LIVMLMGAFVTILNQTLMNVALPSIMKDFGITASQGQWLSTGFMLVNGVMIPMTAFLIER 73 Query: 80 FGAKTVFLTAVIVFTIGSILCATPSRAEWLIAFRVLQGLGGGCVLPVGMAYVYKLAPKSK 139 F + ++L A+I F IG+ + + LIA R++Q +G G V+P+ V L P + Sbjct: 74 FTTRQLYLFAMITFAIGTAIGGFATDYTMLIAGRMVQAIGAGIVMPLLTVVVLNLFPMER 133 Query: 140 XXXXXXXXXXPVLFAPAIGPVLSGWLVEYHSWRWXXXXXXXXXXXXXXXGSRKLPQSVRS 199 + FAPAIGP LSGW+V+ + WR L + Sbjct: 134 RGRAMGLIGLAMNFAPAIGPTLSGWIVQQYDWRNLFFIIIPFAILDIVVAIFLLKNVGKR 193 Query: 200 QVPGMDKLGMILGPLAFASLSYGVSQGAD-SWTSDKTLIGLSVGMLALIAFVIAEFRSET 258 P +D LG+I+ + F SL G S D W + K + +G++ L F+ + ++ Sbjct: 194 TFPKLDILGVIMSTVGFGSLLLGFSNAGDHDWLTWKVAGFIILGLVVLGIFIRYQSSNKA 253 Query: 259 PLLELRILRSIDFSTGILVQWIAQFGLYGAXXXXXXXXXXARGFGAFDTGLTMLPQAIAS 318 PLL ++ + F+ + + GL+G RGF ++GL +LP A+ + Sbjct: 254 PLLNFKVFKYPTFALTTAISFFVVMGLFGGMLLLPIFLQTVRGFSPLESGLVLLPGALVT 313 Query: 319 GLMMPIAGILFDRIGVRWLVVCGLSLVSGALFQYSHVDLATQGKDLILPLFMCGAGMGMM 378 ++ P+ G++FDR G ++L + GL +++G+ F ++++D +T +I+ + AGM M+ Sbjct: 314 AILSPVTGVMFDRFGAKYLSLVGLIIMAGSTFMFTNLDESTTLTFIIIVQTIRSAGMAMV 373 Query: 379 VMPMNTHLLNKAPSHLVNRVTSLTNSMQQVINALAVSTLVTILTS 423 +MP+ T LN P L + +++ N+M+QV ++ + L+T+++ Sbjct: 374 MMPLQTAALNSLPLKLASHGSAMFNTMRQVAGSIGTAALITVMSK 418 >BS_lmrB [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 479 Score = 194 bits (494), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 122/427 (28%), Positives = 219/427 (51%), Gaps = 8/427 (1%) Query: 1 MEQELKSDADFRLLSILVPLLAIIAGVFMVVLDSTAMNVALSTLVKDFHTELNTLQWVVT 60 +E K+ ++++ I++ LL +AG F+ + TA+N+AL+ L+K+ + T+QW+ T Sbjct: 3 LETTAKASQQYKVMPIMISLL--LAG-FIGMFSETALNIALTDLMKELNITAATVQWLTT 59 Query: 61 GYMLAQASVIPLSGWLSDRFGAKTVFLTAVIVFTIGSILCATPSRAEWLIAFRVLQGLGG 120 GY+L ++P+SG L F + +F ++I +G+ + A +L+A R++Q LG Sbjct: 60 GYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALAPSFSFLLAARIVQALGT 119 Query: 121 GCVLPVGMAYVYKLAPKSKXXXXXXXXXXPVLFAPAIGPVLSGWLVEYHSWRWXXXXXXX 180 G +LP+ + + P K ++FAPAIGP SG ++E+ +W W Sbjct: 120 GLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLEHLNWHWIFWISLP 179 Query: 181 XXXXXXXXGSRKLPQSVRSQVPGMDKLGMILGPLAFASLSYGVS---QGADSWTSDKTLI 237 G + + P +D L +IL + F + +G S +G+ W+S ++ Sbjct: 180 FLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGIVFGFSNAGEGSGGWSSPTVIV 239 Query: 238 GLSVGMLALIAFVIAEFRSETPLLELRILRSIDFSTGILVQWIAQFGLYGAXXXXXXXXX 297 L VG++ LI F I + + P++ LR + F G+++ +I + + Sbjct: 240 SLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILGVIMVFICMMVILSSMLLLPMYLQ 299 Query: 298 XARGFGAFDTGLTMLPQAIASGLMMPIAGILFDRIGVRWLVVCGLSLVSGALFQYSHVDL 357 AF +GL +LP I +G M P+ G LFD+ G +WLV+ G +V+ L+ +S+V Sbjct: 300 GGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKYGPKWLVIPGFVIVTVVLWFFSNVT- 358 Query: 358 ATQGKDLILPLFMC-GAGMGMMVMPMNTHLLNKAPSHLVNRVTSLTNSMQQVINALAVST 416 T LI+ L C G+ M++MP T+ LN+ P T++ N++QQ+ A+ + Sbjct: 359 TTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQLPREFYPDGTAIMNTLQQMAGAIGTAV 418 Query: 417 LVTILTS 423 V+I+ + Sbjct: 419 AVSIMAA 425 >lin0519 [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 471 Score = 179 bits (455), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 124/425 (29%), Positives = 213/425 (50%), Gaps = 6/425 (1%) Query: 1 MEQELKSDADFRLLSILVPLLAIIAGVFMVVLDSTAMNVALSTLVKDFHTELNTLQWVVT 60 M+QE R + I+ L +AG F+ + TA+N+ALS L++ F T+QW+ T Sbjct: 1 MQQEATGGQKIRPIPIIASFL--MAG-FIGLFSETALNMALSDLIQVFDISSATVQWLTT 57 Query: 61 GYMLAQASVIPLSGWLSDRFGAKTVFLTAVIVFTIGSILCA-TPSRAEWLIAFRVLQGLG 119 GY+L ++P+SG L F + +F TAV G+++ A +P+ A +I RV+Q +G Sbjct: 58 GYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIG-RVVQAVG 116 Query: 120 GGCVLPVGMAYVYKLAPKSKXXXXXXXXXXPVLFAPAIGPVLSGWLVEYHSWRWXXXXXX 179 +LP+ + + P+ K ++FAPA+GP +SG ++E +W W Sbjct: 117 TALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISL 176 Query: 180 XXXXXXXXXGSRKLPQSVRSQVPGMDKLGMILGPLAFASLSYGVSQ-GADSWTSDKTLIG 238 G + + P +D L +IL L F + + S G + W S L+ Sbjct: 177 PFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGENGWGSATVLVS 236 Query: 239 LSVGMLALIAFVIAEFRSETPLLELRILRSIDFSTGILVQWIAQFGLYGAXXXXXXXXXX 298 + VG +AL FV + E PL++L++ + F+ G+++ +I+ + Sbjct: 237 IIVGGIALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQN 296 Query: 299 ARGFGAFDTGLTMLPQAIASGLMMPIAGILFDRIGVRWLVVCGLSLVSGALFQYSHVDLA 358 + AF GL +LP + +GLM P G LFD G R LV+ G + ALF + +++ Sbjct: 297 SLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVIALFFLTRIEVG 356 Query: 359 TQGKDLILPLFMCGAGMGMMVMPMNTHLLNKAPSHLVNRVTSLTNSMQQVINALAVSTLV 418 T +I+ + G+ M++MP T+ LN+ P L T++ N++QQV A+ + + Sbjct: 357 TSALTIIVLHSVLMIGISMVMMPAQTNGLNQLPPKLYPDGTAIMNTLQQVSGAIGTAVAI 416 Query: 419 TILTS 423 TI+++ Sbjct: 417 TIMSA 421 >MT0807 [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 545 Score = 177 bits (448), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 121/400 (30%), Positives = 204/400 (51%), Gaps = 7/400 (1%) Query: 29 MVVLDSTAMNVALSTLVKDFHTELNTLQWVVTGYMLAQASVIPLSGWLSDRFGAKTVFLT 88 M +D T ++VA T V DF + + W +TGYMLA A+VIP +GW +DRFG + +F+ Sbjct: 59 MAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMG 118 Query: 89 AVIVFTIGSILCATPSRAEWLIAFRVLQGLGGGCVLPVGMAYVYKLAPKSKXXXXXXXXX 148 +V+ FT+GS+LCA LI FRV+QG GGG + PV A + + A + Sbjct: 119 SVLAFTLGSLLCAVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPKRLGRVMAVVG 178 Query: 149 XPVLFAPAIGPVLSGWLVEYHSWRWXXXXXXXXXXXXXXXGSRKLPQSVRSQVPGMDKLG 208 P+L P GP+L GWL+ + WRW + P+ + D +G Sbjct: 179 IPMLLGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASENFDYMG 238 Query: 209 MILGPLAFASLSYGVSQGADSWT-SDKTLIGLSVGMLALIAFVIAE--FRSETPLLELRI 265 ++L A+ +GVS T +D+ ++ ++ LALIA +A +R+E PL+++R+ Sbjct: 239 LLLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTEHPLIDMRL 298 Query: 266 LRSIDFSTGILVQWIAQFGLYGAXXXXXXXXXXARGFGAFDTGLTMLPQAIASGLMMPIA 325 ++ + + + GL+G+ +G+ ++PQ + + L MPIA Sbjct: 299 FQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQSGVHIIPQGLGAMLAMPIA 358 Query: 326 GILFDRIGVRWLVVCGLSLVSGALFQYSHVDLATQGKDL-ILPLFMCGAGMGMM--VMPM 382 G + DR G +V+ G+ L++ L ++ +A Q L ILP + GMGM+ +MP+ Sbjct: 359 GAMMDRRGPAKIVLVGIMLIAAGLGTFAF-GVARQADYLPILPTGLAIMGMGMVCSMMPL 417 Query: 383 NTHLLNKAPSHLVNRVTSLTNSMQQVINALAVSTLVTILT 422 + + H + R ++L + QQV ++ + + +LT Sbjct: 418 SGAAVQTLAPHQIARGSTLISVNQQVGGSIGTALMSVLLT 457 >Rv0783c [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 540 Score = 166 bits (421), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 122/400 (30%), Positives = 204/400 (51%), Gaps = 7/400 (1%) Query: 29 MVVLDSTAMNVALSTLVKDFHTELNTLQWVVTGYMLAQASVIPLSGWLSDRFGAKTVFLT 88 M +D T ++VA T V DF + + W +TGYMLA A+VIP +GW +DRFG + +F+ Sbjct: 54 MAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMG 113 Query: 89 AVIVFTIGSILCATPSRAEWLIAFRVLQGLGGGCVLPVGMAYVYKLAPKSKXXXXXXXXX 148 +V+ FT+GS+LCA LI FRV+QG GGG + PV A + + A + Sbjct: 114 SVLAFTLGSLLCAVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPKRLGRVMAVVG 173 Query: 149 XPVLFAPAIGPVLSGWLVEYHSWRWXXXXXXXXXXXXXXXGSRKLPQSVRSQVPGMDKLG 208 P+L P GP+L GWL+ + WRW + P+ + D +G Sbjct: 174 IPMLLGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASENFDYMG 233 Query: 209 MILGPLAFASLSYGVSQGADSWT-SDKTLIGLSVGMLALIAFVIAE--FRSETPLLELRI 265 ++L A+ +GVS T +D+ ++ ++ LALIA +A +R+E PL+++R+ Sbjct: 234 LLLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTEHPLIDMRL 293 Query: 266 LRSIDFSTGILVQWIAQFGLYGAXXXXXXXXXXARGFGAFDTGLTMLPQAIASGLMMPIA 325 ++ + + + GL+G+ +G+ ++PQ + + L MPIA Sbjct: 294 FQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQSGVHIIPQGLGAMLAMPIA 353 Query: 326 GILFDRIGVRWLVVCGLSLVSGALFQYSHVDLATQGKDL-ILP--LFMCGAGMGMMVMPM 382 G + DR G +V+ G+ L++ L ++ +A Q L ILP L + G GMG +MP+ Sbjct: 354 GAMMDRRGPAKIVLVGIMLIAAGLGTFA-FGVARQADYLPILPTGLAIMGMGMGCSMMPL 412 Query: 383 NTHLLNKAPSHLVNRVTSLTNSMQQVINALAVSTLVTILT 422 + + H + R ++L + QQV ++ + + +LT Sbjct: 413 SGAAVQTLAPHQIARGSTLISVNQQVGGSIGTALMSVLLT 452 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.325 0.139 0.417 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 30,075,506 Number of extensions: 1041475 Number of successful extensions: 3461 Number of sequences better than 1.0e-05: 74 Number of HSP's gapped: 3369 Number of HSP's successfully gapped: 78 Length of query: 506 Length of database: 38,378,431 Length adjustment: 111 Effective length of query: 395 Effective length of database: 25,576,357 Effective search space: 10102661015 Effective search space used: 10102661015 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 118 (50.1 bits)