BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0578.0001.p (395 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4916 [F] COG1051 ADP-ribose pyrophosphatase 91 4e-18 slr1690 [F] COG1051 ADP-ribose pyrophosphatase 90 6e-18 DR0192 [F] COG1051 ADP-ribose pyrophosphatase 90 8e-18 mll5836 [R] COG4111 Uncharacterized conserved protein 80 5e-15 alr2484 [F] COG1051 ADP-ribose pyrophosphatase 80 6e-15 >PA4916 [F] COG1051 ADP-ribose pyrophosphatase Length = 346 Score = 90.5 bits (223), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 17/254 (6%), Positives = 38/254 (14%), Gaps = 63/254 (24%) Query: 149 SLQLLMIQRGEHPYLGQWALPGGFV---GVDESLEDAALRELYSETNIDNVYMEQLYTWG 205 + + H L G + + + +ET + N + Sbjct: 22 TFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSREK 81 Query: 206 DVGRDPRMRVISSSYIALVDRKTLDVQXXXXXXXXXWFEVTYDVLESGRRELAEGYMEEQ 265 + ++ + + Sbjct: 82 LIIASKVSGPSRNNDKGIRPDQA------------------------------------- 104 Query: 266 KIRITLQKEDVELTGVVTITETVQGHVRRVRREIAENHGFAFDHLKMIQYAIERLRGKVE 325 + H R + + Q Sbjct: 105 ------LDRKNIREAL---------HDSLKR---LQTDYLDLYQVHWPQRPTNCFGKLGY 146 Query: 326 YTDIIFNLMPPLFTLSELQRVYEIILGRELLAPAFRRKI-----ADSVTETEEFTKDAGH 380 + L TL L R + + + Sbjct: 147 SWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQN 206 Query: 381 RPSKLYRYRADKGS 394 S L R + Sbjct: 207 PYSLLNRSFEVGLA 220 >slr1690 [F] COG1051 ADP-ribose pyrophosphatase Length = 261 Score = 90.1 bits (222), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 71/243 (29%), Positives = 109/243 (44%), Gaps = 61/243 (25%) Query: 156 QRGEHPYLGQWALPGGFVGVDESLEDAALRELYSETNIDNVYMEQLYTWGDVGRDPRMRV 215 +R + PY W+ PG V + E+LE AA R L + + N+Y+EQLYT+G+ GRDPR Sbjct: 58 KREDQPYQNYWSFPGTLVRMGETLEGAAHRILSEKIAVKNLYLEQLYTFGNPGRDPR--- 114 Query: 216 ISSSYIALVDRKTLDVQXXXXXXXXXWFEVTYDVLESGRRELAEGYMEEQKIRITLQKED 275 + D + G R L+ Y ++ ED Sbjct: 115 -----------EAPD--------------------QYGVRYLSVSYFA------LIRYED 137 Query: 276 VELTGVVTITETVQGHVRRVRREIAENHGFAFDHLKMIQYAIERLRGKVEYTDIIFNLMP 335 +L + V H +A AFDH +++ Y +RLR K+EY+ I F ++P Sbjct: 138 AQL--MSKNLSQVSWH------NVAAIPTLAFDHNQILDYGYQRLRNKLEYSPIAFEVLP 189 Query: 336 PLFTLSELQRVYEIILGRELLA-PAFRRKIADSVTETEEFTKDAGH-------RPSKLYR 387 LFTL++L ++Y +LG + FR ++ F KD G RP+ L+R Sbjct: 190 ELFTLNDLFQLYTTVLGEDFADYSNFRSRLL-----KLGFLKDTGQKISKGVGRPASLFR 244 Query: 388 YRA 390 + A Sbjct: 245 FDA 247 >DR0192 [F] COG1051 ADP-ribose pyrophosphatase Length = 346 Score = 89.7 bits (221), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 10/96 (10%), Positives = 17/96 (17%), Gaps = 2/96 (2%) Query: 150 LQLLMIQRGEHPYLGQWALPGGFVGVDESLEDAALRELYSETNI--DNVYMEQLYTWGDV 207 Q G + + + N + E+L V Sbjct: 29 EADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSREKLIIASKV 88 Query: 208 GRDPRMRVISSSYIALVDRKTLDVQXXXXXXXXXWF 243 R +DRK + Sbjct: 89 SGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTD 124 Score = 59.3 bits (142), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 4/93 (4%), Positives = 14/93 (15%), Gaps = 5/93 (5%) Query: 305 FAFDHLKMIQYAIERLRGKVEYTDIIFNLMPPLFTLSELQRVYEIILGRELLAPAFRRKI 364 + + + + L ++ I + E R Sbjct: 132 HWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLH 191 Query: 365 --ADSVTETEEFTKDAGHRPSKLYRYRADKGSR 395 ++ + Sbjct: 192 LADKHDLPRIVTIQNPY-SLLNRSF-EV-GLAE 221 >mll5836 [R] COG4111 Uncharacterized conserved protein Length = 319 Score = 80.5 bits (197), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 77/262 (29%), Positives = 114/262 (43%), Gaps = 47/262 (17%) Query: 167 ALPGG-FVGVDESLEDAALRELYSETNIDNVYMEQLYTWGDVGR-DPRMRVISSSYIALV 224 ALP G F SL+ + +T Y+EQLYT+ D R RVIS SY+AL Sbjct: 45 ALPSGPFELAHRSLQSGLRAWVELQTGQPLGYIEQLYTFADRDRVGANQRVISISYLALT 104 Query: 225 DRKTLDVQXXXXXXXXXWFE-VTYDVLESGRRELAEGYMEEQKIRI-------------- 269 + D W++ ++ SGR + +EE + R+ Sbjct: 105 REE--DAGASGRRSWASWYDYFPWEDHRSGRPPIV---LEELRPRLIEWADGADDGATRF 159 Query: 270 ---------------------TLQKEDVELTGVVTITETVQGHVRRVRREIAENHGFAFD 308 LQ+ ++ L + E +G V + + A D Sbjct: 160 DRRRRAAVAFALDGRAWNEELALQRYEL-LYEAALVEEAKRGGVSAILPSVPGRSMIA-D 217 Query: 309 HLKMIQYAIERLRGKVEYTDIIFNLMPPLFTLSELQRVYEIILGRELLAPAFRRKIADS- 367 H +++ AI RLR K++Y ++F LMPPLFTL +LQR E + GR + P FRR I Sbjct: 218 HRRILATAIARLRSKIKYRPVVFELMPPLFTLLQLQRTVEALSGRLINKPNFRRLIEQQE 277 Query: 368 -VTETEEFTKDAGHRPSKLYRY 388 V +T T + G RP++LYR+ Sbjct: 278 LVEKTGATTAETGGRPAQLYRF 299 >alr2484 [F] COG1051 ADP-ribose pyrophosphatase Length = 248 Score = 80.1 bits (196), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 74/280 (26%), Positives = 125/280 (44%), Gaps = 74/280 (26%) Query: 125 VTVDMLIFTVMEQEQDNYRKLSEKSLQLLMIQRGEHPYLGQWALPGGFVGVDESLEDAAL 184 V VD +IF+V ++ L +L++ R + P+L W+LPG V ESLEDAA Sbjct: 23 VGVDNVIFSVDTEKN---------RLLVLLVMRQQEPFLNYWSLPGTLVREGESLEDAAY 73 Query: 185 RELYSETNIDNVYMEQLYTWGDVGRDPR-------MRVISSSYIALVDRKTLDVQXXXXX 237 R + + + N+Y+EQLYT+G RDPR +R +S SY ALV Sbjct: 74 RIMAEKIRVKNLYLEQLYTFGGPNRDPREATGSYGVRYLSVSYFALVR------------ 121 Query: 238 XXXXWFEVTYDVLESGRRELAEGYMEEQKIRITLQKEDVELTGVVTITETVQGHVRRVRR 297 FE +++ G +A Y +Q +++ ++ GH RR+R Sbjct: 122 -----FEEA-ELIADGVTGIA-WYPVKQVPKLSFDHNEI----------LAYGH-RRLRN 163 Query: 298 EIAENHGFAFDHLKMIQYAIERLRGKVEYTDIIFNLMPPLFTLSELQRVYEIILGRELLA 357 ++ EY+ + F ++P +FTL++L ++Y +LG Sbjct: 164 KL-------------------------EYSPVAFEVLPEMFTLNDLYQLYTTVLGENFSD 198 Query: 358 PA-FRRKIAD--SVTETEEFTKDAGHRPSKLYRYRADKGS 394 + FR ++ +++T RP+ LY++ A+ S Sbjct: 199 YSNFRARLLKLGFLSDTGIKVSRGAGRPASLYKFDAEAFS 238 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.321 0.138 0.394 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 21,979,705 Number of extensions: 846253 Number of successful extensions: 11926 Number of sequences better than 1.0e-05: 15 Number of HSP's gapped: 11920 Number of HSP's successfully gapped: 18 Length of query: 395 Length of database: 38,378,431 Length adjustment: 108 Effective length of query: 287 Effective length of database: 25,922,359 Effective search space: 7439717033 Effective search space used: 7439717033 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 117 (49.7 bits)