BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0562.0007.p (458 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value MT0807 [GEPR] COG0477 Permeases of the major facilitator superfa... 165 1e-40 Rv0783c [GEPR] COG0477 Permeases of the major facilitator superf... 159 8e-39 lin1658 [GEPR] COG0477 Permeases of the major facilitator superf... 129 1e-29 BS_lmrB [GEPR] COG0477 Permeases of the major facilitator superf... 127 3e-29 HI0852 [GEPR] COG0477 Permeases of the major facilitator superfa... 127 3e-29 >MT0807 [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 545 Score = 165 bits (418), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 113/400 (28%), Positives = 197/400 (49%), Gaps = 3/400 (0%) Query: 44 DTTITNVAIDTLVREFSTSVSTIQWVMTSYLLALGMVIPXXXXXXXXXGGKPMWLFSLGM 103 D T+ +VA T V +F ++ + + W MT Y+LAL VIP G + +++ S+ Sbjct: 63 DVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLA 122 Query: 104 FLLGSVLCSLAWNVESLIFFRTIQGIGGGLLMPIMQTLGVRAFKGENMGKMMATXXXXXX 163 F LGS+LC++A N+ LI FR +QG GGG+L P+ + R + +G++MA Sbjct: 123 FTLGSLLCAVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPKRLGRVMAVVGIPML 182 Query: 164 XXXXXXXXXXXXXXNHLSWRWIFLVNIPICIVAIIMAWRGLPNEERGTRTLRLDLPGLML 223 WRWIFLVN+P+ + A+++A P +R + D GL+L Sbjct: 183 LGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFP-RDRPAASENFDYMGLLL 241 Query: 224 LSPAIVLIIYGLGEVSSNHGFGHSXXXXXXXXXXXXXXXXXXXXFRKGKEALLDIRLFRV 283 LSP + ++G+ + + + + L+D+RLF+ Sbjct: 242 LSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTEHPLIDMRLFQN 301 Query: 284 RSLAVSSILLFLSGLTTYGAMLLLPLYFQQVRGESVLISGLLLVPQGIGMLLTRSLAGKL 343 R++A +++ + + L +G+ LLLP Y QQV +S + SG+ ++PQG+G +L +AG + Sbjct: 302 RAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQSGVHIIPQGLGAMLAMPIAGAM 361 Query: 344 TDQIGSRPVVXXXXXXXXXXXWPFTQLGADTSYYY--LGAALIVRGAGLGAVFLPVMASA 401 D+ G +V F A + Y L L + G G+ +P+ +A Sbjct: 362 MDRRGPAKIVLVGIMLIAAGLGTFAFGVARQADYLPILPTGLAIMGMGMVCSMMPLSGAA 421 Query: 402 YIGLSSQQIPHASSTTRIMQQIGGAFGASVIAIILQNEYN 441 L+ QI S+ + QQ+GG+ G ++++++L ++N Sbjct: 422 VQTLAPHQIARGSTLISVNQQVGGSIGTALMSVLLTYQFN 461 >Rv0783c [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 540 Score = 159 bits (402), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 114/400 (28%), Positives = 198/400 (49%), Gaps = 3/400 (0%) Query: 44 DTTITNVAIDTLVREFSTSVSTIQWVMTSYLLALGMVIPXXXXXXXXXGGKPMWLFSLGM 103 D T+ +VA T V +F ++ + + W MT Y+LAL VIP G + +++ S+ Sbjct: 58 DVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLA 117 Query: 104 FLLGSVLCSLAWNVESLIFFRTIQGIGGGLLMPIMQTLGVRAFKGENMGKMMATXXXXXX 163 F LGS+LC++A N+ LI FR +QG GGG+L P+ + R + +G++MA Sbjct: 118 FTLGSLLCAVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPKRLGRVMAVVGIPML 177 Query: 164 XXXXXXXXXXXXXXNHLSWRWIFLVNIPICIVAIIMAWRGLPNEERGTRTLRLDLPGLML 223 WRWIFLVN+P+ + A+++A P +R + D GL+L Sbjct: 178 LGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFP-RDRPAASENFDYMGLLL 236 Query: 224 LSPAIVLIIYGLGEVSSNHGFGHSXXXXXXXXXXXXXXXXXXXXFRKGKEALLDIRLFRV 283 LSP + ++G+ + + + + L+D+RLF+ Sbjct: 237 LSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTEHPLIDMRLFQN 296 Query: 284 RSLAVSSILLFLSGLTTYGAMLLLPLYFQQVRGESVLISGLLLVPQGIGMLLTRSLAGKL 343 R++A +++ + + L +G+ LLLP Y QQV +S + SG+ ++PQG+G +L +AG + Sbjct: 297 RAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQSGVHIIPQGLGAMLAMPIAGAM 356 Query: 344 TDQIGSRPVVXXXXXXXXXXXWPFTQLGADTSYYY--LGAALIVRGAGLGAVFLPVMASA 401 D+ G +V F A + Y L L + G G+G +P+ +A Sbjct: 357 MDRRGPAKIVLVGIMLIAAGLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAA 416 Query: 402 YIGLSSQQIPHASSTTRIMQQIGGAFGASVIAIILQNEYN 441 L+ QI S+ + QQ+GG+ G ++++++L ++N Sbjct: 417 VQTLAPHQIARGSTLISVNQQVGGSIGTALMSVLLTYQFN 456 >lin1658 [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 489 Score = 129 bits (324), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 103/438 (23%), Positives = 198/438 (45%), Gaps = 19/438 (4%) Query: 19 EAVEQQAAAKKMMWILMVGMLAPLFDTTITNVAIDTLVREFSTSVSTIQWVMTSYLLALG 78 +A ++ ++++G + + T+ NVA+ +++++F + S QW+ T ++L G Sbjct: 2 KAASTSVKRNGILIVMLMGAFVTILNQTLMNVALPSIMKDFGITASQGQWLSTGFMLVNG 61 Query: 79 MVIPXXXXXXXXXGGKPMWLFSLGMFLLGSVLCSLAWNVESLIFFRTIQGIGGGLLMPIM 138 ++IP + ++LF++ F +G+ + A + LI R +Q IG G++MP++ Sbjct: 62 VMIPMTAFLIERFTTRQLYLFAMITFAIGTAIGGFATDYTMLIAGRMVQAIGAGIVMPLL 121 Query: 139 QTLGVRAFKGENMGKMMATXXXXXXXXXXXXXXXXXXXXNHLSWRWIFLVNIPICIVAII 198 + + F E G+ M WR +F + IP I+ I+ Sbjct: 122 TVVVLNLFPMERRGRAMGLIGLAMNFAPAIGPTLSGWIVQQYDWRNLFFIIIPFAILDIV 181 Query: 199 MAWRGLPNEERGTRTL-RLDLPGLMLLSPAIVLIIYGLGEVSSNHGFGHSXXXXXXXXXX 257 +A L N G RT +LD+ G+++ + ++ G SN G H Sbjct: 182 VAIFLLKNV--GKRTFPKLDILGVIMSTVGFGSLLLGF----SNAG-DHDWLTWKVAGFI 234 Query: 258 XXXXXXXXXXFR---KGKEALLDIRLFRVRSLAVSSILLFLSGLTTYGAMLLLPLYFQQV 314 R K LL+ ++F+ + A+++ + F + +G MLLLP++ Q V Sbjct: 235 ILGLVVLGIFIRYQSSNKAPLLNFKVFKYPTFALTTAISFFVVMGLFGGMLLLPIFLQTV 294 Query: 315 RGESVLISGLLLVPQGIGMLLTRSLAGKLTDQIGSRPVVXXXXXXXXXXXWPFTQLGADT 374 RG S L SGL+L+P + + + G + D+ G++ + + FT L T Sbjct: 295 RGFSPLESGLVLLPGALVTAILSPVTGVMFDRFGAKYLSLVGLIIMAGSTFMFTNLDEST 354 Query: 375 SYYYLGAALIVRGAGLGAVFLPVMASAYIGLSSQQIPHASSTTRIMQQIGGAFGASVIAI 434 + ++ +R AG+ V +P+ +A L + H S+ M+Q+ G+ G + + Sbjct: 355 TLTFIIIVQTIRSAGMAMVMMPLQTAALNSLPLKLASHGSAMFNTMRQVAGSIGTAALI- 413 Query: 435 ILQNEYNSVMSQNPAAIA 452 +VMS++ A+ A Sbjct: 414 -------TVMSKSAASFA 424 >BS_lmrB [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 479 Score = 127 bits (320), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 102/441 (23%), Positives = 191/441 (43%), Gaps = 5/441 (1%) Query: 16 ETFEAVEQQAAAKKMMWILMVGMLAPLFDTTITNVAIDTLVREFSTSVSTIQWVMTSYLL 75 ET QQ +M L++ +F T N+A+ L++E + + +T+QW+ T YLL Sbjct: 4 ETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLL 63 Query: 76 ALGMVIPXXXXXXXXXGGKPMWLFSLGMFLLGSVLCSLAWNVESLIFFRTIQGIGGGLLM 135 LG+++P + ++ SL +LG+ + +LA + L+ R +Q +G GLL+ Sbjct: 64 VLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALAPSFSFLLAARIVQALGTGLLL 123 Query: 136 PIMQTLGVRAFKGENMGKMMATXXXXXXXXXXXXXXXXXXXXNHLSWRWIFLVNIPICIV 195 P+M + F G M T HL+W WIF +++P ++ Sbjct: 124 PLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLEHLNWHWIFWISLPFLVL 183 Query: 196 AIIMAWRGLPNEERGTRTLRLDLPGLMLLSPAIVLIIYGLGEVSSNHGFGHSXXXXXXXX 255 A++ + N T+ ++D+ ++L + I++G G S Sbjct: 184 ALVFGIAYMQNVSETTKP-KIDVLSIILSTIGFGGIVFGFSNAGEGSGGWSSPTVIVSLI 242 Query: 256 XXXXXXXXXXXXFRKGKEALLDIRLFRVRSLAVSSILLFLSGLTTYGAMLLLPLYFQQVR 315 K+ ++++R F+ + I++F+ + +MLLLP+Y Q Sbjct: 243 VGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILGVIMVFICMMVILSSMLLLPMYLQGGL 302 Query: 316 GESVLISGLLLVPQGIGMLLTRSLAGKLTDQIGSRPVVXXXXXXXXXXXWPFTQLGADTS 375 + SGL+L+P GI + G+L D+ G + +V W F+ + ++ Sbjct: 303 VLTAFASGLVLLPGGILNGFMSPVTGRLFDKYGPKWLVIPGFVIVTVVLWFFSNVTTTST 362 Query: 376 YYYLGAALIVRGAGLGAVFLPVMASAYIGLSSQQIPHASSTTRIMQQIGGAFGASVIAII 435 + G+ + +P + L + P ++ +QQ+ GA G +V I Sbjct: 363 AVLIIILHTCLMIGISMIMMPAQTNGLNQLPREFYPDGTAIMNTLQQMAGAIGTAVAVSI 422 Query: 436 L---QNEYNSVMSQNPAAIAV 453 + Q++Y S + +NPA AV Sbjct: 423 MAAGQHDYMSTV-KNPADPAV 442 >HI0852 [GEPR] COG0477 Permeases of the major facilitator superfamily Length = 463 Score = 127 bits (320), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 117/431 (27%), Positives = 187/431 (43%), Gaps = 17/431 (3%) Query: 23 QQAAAKKMMWILMVGMLAPLFDTTITNVAIDTLVREFSTSVSTIQWVMTSYLLALGMVIP 82 + A + + W+ + + D TI N A+ + + +Q + +Y LA+ + IP Sbjct: 4 ESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIP 63 Query: 83 XXXXXXXXXGGKPMWLFSLGMFLLGSVLCSLAWNVESLIFFRTIQGIGGGLLMPIMQTLG 142 G ++ ++ F+LGSV C+ A N+ESLI R IQGIGG +MP+ + Sbjct: 64 LTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAI 123 Query: 143 VRAFKGE---NMGKMMATXXXXXXXXXXXXXXXXXXXXNHLSWRWIFLVNIPICIVAIIM 199 ++A + N +MAT H SW WIFL+NIPI + I+ Sbjct: 124 IQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVI---HASWHWIFLINIPIGALG-IL 179 Query: 200 AWRGLPNEERGTRTLRLDLPGLMLLSPAIVLIIYG---LGEVSSNHGFGHSXXXXXXXXX 256 A + N +G + +LD G +L + +V I G LGE N +S Sbjct: 180 ASGSVMNNIKG-KAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLL 238 Query: 257 XXXXXXXXXXXFRKGKEALLDIRLFRVRSLAVSSILLFLSGLTTYGAMLLLPLYFQQVRG 316 + + A+L + LFR R+ + I L+ G LLPL FQ G Sbjct: 239 VTYCGYA-----KNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFG 293 Query: 317 ESVLISGLLLVPQGIGMLLTRSLAGKLTDQIGSRPVVXXXXXXXXXXXWPFTQLGADTSY 376 S +SG LL P + ++ + L G++ ++ G + + L +S Sbjct: 294 YSAEMSGWLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVISMAWLDKQSSL 353 Query: 377 YYLGAALIVRGAGLGAVFLPVMASAYIGLSSQQIPHASSTTRIMQQIGGAFGASVIAIIL 436 ++ L+ GA + +F + A LS QQ S+ I+QQ+G FG +V +IIL Sbjct: 354 TWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIIL 413 Query: 437 QNEYNSVMSQN 447 N Y S + Sbjct: 414 -NLYRHFFSAS 423 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.326 0.139 0.414 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 26,312,692 Number of extensions: 913507 Number of successful extensions: 2789 Number of sequences better than 1.0e-05: 46 Number of HSP's gapped: 2718 Number of HSP's successfully gapped: 56 Length of query: 458 Length of database: 38,378,431 Length adjustment: 110 Effective length of query: 348 Effective length of database: 25,691,691 Effective search space: 8940708468 Effective search space used: 8940708468 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 117 (49.7 bits)