BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0560.0026.p (2351 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_ppsA_2 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 744 0.0 PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and ... 720 0.0 RSp0641_6 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 711 0.0 all2642 [Q] COG1020 Non-ribosomal peptide synthetase modules and... 667 0.0 RSp0641_7 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 655 0.0 >BS_ppsA_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Length = 792 Score = 744 bits (1920), Expect = 0.0, Method: Compositional matrix adjust. Identities = 0/1294 (0%), Positives = 0/1294 (0%), Gaps = 91/1294 (7%) Query: 860 TEKRDYYPMSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEIL 919 P+ ++ + ++ E++ + V + ++ L Sbjct: 1 MSNNGSSPLVLWYNQLGMNDVDRVGGKNASLGEMITNLSGMGVSVPNGFATTADAFNQFL 60 Query: 920 RTSFHM-IHHEPVQVVHDTIDFSIDYTEEKIDDIRLEADRFIQPFDLDTSPLFRVKIIKI 978 S +E + + +I ++ + + ++ Sbjct: 61 DQSGVNQRIYELLDKTDIDDVTQLAKAGAQIRQWIIDTPFQPELENAIREAYAQLSADDE 120 Query: 979 ASRHYLFMFDMHHIISDGISIGLFIKELALLYGNAVLPEPEIQFKDFSVWEKESAENGD- 1037 + + + D G L + +AVL + F + + Sbjct: 121 NASFAVRSSATAEDMPDASFAGQQETFLNVQGFDAVLVAVKHVFASLFND-RAISYRVHQ 179 Query: 1038 FKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKELAGDNGAT 1097 L + +L + G + + G Sbjct: 180 GYDHRGVALSAGVQRMVRSDLASSGVMFSIDTESGFDQVVFITSAWGLGEMVVQGAVNPD 239 Query: 1098 LYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFPAGNKRFK 1157 + + I + + E + + R+ + Sbjct: 240 EFYVHKPTLAANRPAIVRRTMGSKKIRMVYAPTQEHGKQVKIEDVPQEQRDIFSLTNEEV 299 Query: 1158 DFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQFQFGEMK 1217 L + + + P G++ Sbjct: 300 QELAKQAVQIEKHYGRPMDIEWAKDGHTGKLFIVQARPETVRSRGQVMERYTLHSQGKII 359 Query: 1218 VSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDYLKAIVNQVIAD 1277 H I + + + + E ++ AIV Sbjct: 360 AEGRAIGHRIGAGPVKVIHDI-SEMNRIEPGDVLVTDMTDPDWEPIMKKASAIVTNRGGR 418 Query: 1278 REIRISDICMVSENAVQQIL-AFNQTSFDLP-ADQTIHGLFEEQAKRRGDEPALEFLDQT 1335 + AV A + G + +T Sbjct: 419 TCHAAIIARELGIPAVVGCGDATERMKDGENVTVSCAEGDTGYVYAELLEFSVKSSSVET 478 Query: 1336 MSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGGAYLPIDPDYP 1395 M L N G+ R ++ +G+ Sbjct: 479 MPDLPLKVMMNVGNPDRAFDF-ACLPNEGVGLARLEFIINRMIGVHPRALLEFDDQEPQL 537 Query: 1396 GERIKFMIEDSGIQLVLTQ--------NIP-----YNWLDFDGEVIDLNCAGLNNMDGSN 1442 I+ M++ + + + Sbjct: 538 QNEIREMMKGFDSPREFYVGRLTEGIATLGAAFYPKRVIVRLSDFKSNEY----ANLVGG 593 Query: 1443 LPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRE--RVVQFSSI 1500 + G G + + L ++++ D V Sbjct: 594 ER-----YEPDEENPMLGFRGAGRYVSDSFRDCFALECEAVKRVRN-DMGLTNVEIMIPF 647 Query: 1501 SFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRIT------AAILPPTYLAN 1554 V + L L + C + + Sbjct: 648 VRTVDQAKAVVEELARQGLKRGENGLKIIMMCEIPSNALLAEQFLEYFDGFSIGSNDMTQ 707 Query: 1555 LNPNNIHTVDKMITIGSAISSG-----LVNEWKRKCEYINAYGPTETTVYSSVWIANKQG 1609 L + + L + + G A Sbjct: 708 LALGLDRDSGVVS-ELFDERNDAVKALLSMAIRAAKKQGKYVGICGQGPSDHEDFAAWLM 766 Query: 1610 E-VDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIIT 1668 E Sbjct: 767 EE 826 Query: 1669 AADSRIGKVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVI 1728 Sbjct: 827 886 Query: 1729 VTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKID 1788 Sbjct: 887 - 945 Query: 1789 QKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQV 1848 Sbjct: 946 -- 1003 Query: 1849 AAILGKHRLHMEIKDLFHRQKIAELSECVRDLRNNPIVENPVGRIDSSGTEGDASIEVLC 1908 Sbjct: 1004 --------- 1054 Query: 1909 SIWLGEIKDQELRHTESIRNAPLVGKHLPAAVQKYHLMNAEKVHTSIPFRSCGDIGKIQK 1968 Sbjct: 1055 ----------------- 1097 Query: 1969 AILRLVNEQVLLRSVIVNDGENTYFYEHGSVYNLPFILIDLSGFDAARRSECLAYLQDHF 2028 Sbjct: 1098 ---- 1153 Query: 2029 NKLPFERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQLAAYF-----AGD 2083 Sbjct: 1154 - 1212 Query: 2084 SSLPVHSLKHHQNYWDYAD---QMQKGPQNLSEQ 2114 Sbjct: 1213 ---- 1242 Score = 416 bits (1069), Expect = e-115, Method: Compositional matrix adjust. Identities = 0/1192 (0%), Positives = 0/1192 (0%), Gaps = 93/1192 (7%) Query: 18 KKKKKYWLNRVVGSETDSRILTD----PHKSALGIEGKESLRLDIPDGLFQQLQHLSNRS 73 + L+ V S + + + G + + G + Sbjct: 181 YDHRGVALSAGVQRMVRSDLASSGVMFSIDTESGFDQVVFITSAWGLGEMV----VQGAV 236 Query: 74 DDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHYVPIIDTFTT------ 127 + +Y+ L ++ + + + + Sbjct: 237 NPDEFYVHKPTLAANRPAIVRRTMGSKKIRM------VYAPTQEHGKQVKIEDVPQEQRD 290 Query: 128 ----GMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHN 183 + L + Y + Sbjct: 291 IFSLTNEEVQELAKQAVQIEKHYGRPMDIEWAKDGHTGKLFIVQARPETVRSRGQVMERY 350 Query: 184 D-------AVIPDVGSNIVFGF------TRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQ 230 + + + + T + K+ Sbjct: 351 TLHSQGKIIAEGRAIGHRIGAGPVKVIHDISEMNRIEPGDVLVTDMTDPDWEPIMKKASA 410 Query: 231 ILKGAAENVSIKLG--SMXXXXXXXXXXXXXXQTRTYQNMEDMTLYELFEKQVRQTPDHV 288 I+ + + +N+ + + Sbjct: 411 IVTNRGGRTCHAAIIARELGIPAVVGCGDATERMKDGENVTVSCAEGDTGYVYAELLEFS 470 Query: 289 AVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAY 348 + +++ L N G+ + R + ++G+ Sbjct: 471 VKSSSVETMPDLPLKVMMNVGNPDRAFDF-ACLPNEGVGLARLEFIINRMIGVHPRALLE 529 Query: 349 LPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDG---LTVIRLDDDVLLENESDLD 405 + ++ +++ + E + G + + ++ Sbjct: 530 FDDQEPQLQNEIREMMKGFDSPREFYVGRLTEGIATLGAAFYPKRVIVRLSDFK-SNEYA 588 Query: 406 LILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNT-IQWRKSEYSFDASD-RMLQLFSY 463 ++G P G G + V R + K D + + + Sbjct: 589 NLVGGERYEPDEENPMLGFRGAGRYVSDSFRDCFALECEAVKR-VRNDMGLTNVEIMIPF 647 Query: 464 IFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMK 523 + ++ + + + I L + Sbjct: 648 VRTVDQAKAVVEELARQGLKRGENGLKIIMMCEIPSNALLAEQFLEYFDGFSIGSNDMTQ 707 Query: 524 PEEAQ--SLRIVTLAGEKV-TPNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDD 580 +V+ ++ + S + + G + Sbjct: 708 LALGLDRDSGVVSELFDERNDAVKALLSMAIRAAKKQGKYVGICGQGPSDHEDFAAWLME 767 Query: 581 T---ELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSN 637 Sbjct: 768 EGID 827 Query: 638 PFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVV 697 Sbjct: 828 887 Query: 698 ALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDR 757 Sbjct: 888 - 946 Query: 758 NALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLL 817 Sbjct: 947 -- 1004 Query: 818 SRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPTEKRDYYPMSSAQKRMYA 877 Sbjct: 1005 ----- 1059 Query: 878 LYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMIHHEPVQVVHDT 937 Sbjct: 1060 -- 1117 Query: 938 ID---------FSIDYTEEKID----DIRLEADRFI--QPFDLDTSPLFRVKIIKIASRH 982 Sbjct: 1118 1177 Query: 983 YLFMFDMHHIISDGISIGLFIKELALLYGNAV------LPEPEIQFKDFSVWEKESAENG 1036 Sbjct: 1178 - 1236 Query: 1037 DFKQQEEFWLKMFKGEVPLLELPVDYKR-PVHKSYEGSKIPFTLDKETTRKLK-ELAGDN 1094 Sbjct: 1237 -- 1294 Query: 1095 GATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRR----QVELESVMGMFSN 1142 Sbjct: 1295 1346 >PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Length = 346 Score = 720 bits (1858), Expect = 0.0, Method: Compositional matrix adjust. Identities = 0/1306 (0%), Positives = 0/1306 (0%), Gaps = 72/1306 (5%) Query: 629 LTRDKFVSNPF-EANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLL 687 + + + + + + + + A Q E+ + R Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPE 60 Query: 688 EYNGITEAVVALWEDQNDNSRICAYIVCD------RVLSALE-LRESLSKSLPEYMLPTH 740 V + + + +R + H Sbjct: 61 TQGLTETYVGNWLAKH-----GSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALH 115 Query: 741 FFQLEQFPMTPTGKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIH 800 + + S L + I Sbjct: 116 DSLKRLQTDYLDLYQVHWPQ-RPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIR 174 Query: 801 DNFFMLGGHSLKATMLLSRLHKEFQVEIELDEIFEKQTICNLAALIKSKRPGTYSSILPT 860 L + + + + L + +L Sbjct: 175 YIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVS-QYEGVELLAY 233 Query: 861 EKRDYYPMSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILR 920 + ++ S + V+ R + ++ Sbjct: 234 SCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMAL 293 Query: 921 TSFHMIHHEPVQVVHDTIDFSID-YTEEKIDDIRLEAD---RFIQPFDLDTSPLFRVKII 976 ++ T + E ++ + Sbjct: 294 AFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEI 353 Query: 977 KIASRHYLFMFDMHHIISDGISIGLFIKELALLYG------NAVLPEPEIQFKDFSVWEK 1030 Sbjct: 354 413 Query: 1031 ESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLKEL 1090 Sbjct: 414 473 Query: 1091 AGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRNFP 1150 Sbjct: 474 533 Query: 1151 AGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNIAVNQ 1210 Sbjct: 534 --- 590 Query: 1211 FQFGEMKV---SFYEH--EHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMID 1265 Sbjct: 591 - 649 Query: 1266 YLKAIVNQVIADREIRISDICMVSENAVQQI-LAFNQTSFDLPADQTIHGLFEEQAKRRG 1324 Sbjct: 650 709 Query: 1325 DEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSG 1384 Sbjct: 710 769 Query: 1385 GAYLPIDPDYPGERIKFMIEDSGIQLVLTQNIPYNWLDFDGEVIDLNCAGLNN-MDGSNL 1443 Sbjct: 770 --- 826 Query: 1444 P-----VINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRERVVQFS 1498 Sbjct: 827 886 Query: 1499 SISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYLANLNPN 1558 Sbjct: 887 - 945 Query: 1559 -----NIHTVDKMITIGSAISSGLVN-EWKR-KCEYI-NAYGPTETTVYSSVWIANKQGE 1610 Sbjct: 946 1005 Query: 1611 VDDP-VPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITA 1669 Sbjct: 1006 1065 Query: 1670 ADSRIG-KVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVI 1728 Sbjct: 1066 1125 Query: 1729 VTHRKNQLQHASICAYYISAMDYSV-----------TELRKQLLSKLPEFMIPAYFVRME 1777 Sbjct: 1126 -- 1183 Query: 1778 AFPLTSNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFE 1837 Sbjct: 1184 - 1242 Query: 1838 VGGDSLKAMQVAAILGKHRLHME--IKDLFHRQKIAELSECVRDLR 1881 Sbjct: 1243 - 1287 Score = 350 bits (899), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 0/879 (0%), Positives = 0/879 (0%), Gaps = 46/879 (5%) Query: 12 LSTSEMKKKKKYWLNRVVGSETDSRILTD-PHKSALGIEGKESLRLDIPDGLFQQLQHLS 70 Sbjct: 416 - 474 Query: 71 NRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYNHY---VPIIDTFTT 127 Sbjct: 475 534 Query: 128 G-MTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCLLTNIHNDAV 186 Sbjct: 535 594 Query: 187 IPDVGS---------------NIVFGFTRDDAGISLNLIYNLKYFTRNFVMQLAKQYFQI 231 Sbjct: 595 654 Query: 232 LKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNMEDMTL-YELFEKQVRQTPDHVAV 290 Sbjct: 655 714 Query: 291 KFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGILKSGAAYLP 350 Sbjct: 715 774 Query: 351 LDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLK-RDGLTVIRLDDDVLLENESDLDLILG 409 Sbjct: 775 834 Query: 410 RALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDASDRMLQLFSYIFDGFL 469 Sbjct: 835 894 Query: 470 TSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPTLYSALLRNMKPE-EAQ 528 Sbjct: 895 - 953 Query: 529 SLRIVTLAGEKVT-PNLLIASKQLHPGMEIVNEYGPTESSVLATLKRDLKPDDTE---LT 584 Sbjct: 954 - 1012 Query: 585 IGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDKFVSNPFEA-NE 643 Sbjct: 1013 1072 Query: 644 RMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQ 703 Sbjct: 1073 - 1131 Query: 704 NDNSRICAYIVCDRVLSA----------LELRESLSKSLPEYMLPTHFFQLEQFPMTPTG 753 Sbjct: 1132 1191 Query: 754 KMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKA 813 Sbjct: 1192 - 1250 Query: 814 TMLLSRLHKEFQVEIELDEIFEKQTI---CNLAALIKSK 849 Sbjct: 1251 1289 >RSp0641_6 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Length = 346 Score = 711 bits (1834), Expect = 0.0, Method: Compositional matrix adjust. Identities = 0/1043 (0%), Positives = 0/1043 (0%), Gaps = 42/1043 (4%) Query: 862 KRDYYPMSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRT 921 + + S+ + + + + + + Sbjct: 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPE 60 Query: 922 SFHMIHHEPVQ-VVHDTIDFSIDYTEEKIDDIRLEADR-----------FIQPFDLDTSP 969 + + + + R + + Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIA-----SKVSGPSRNNDKGIRPDQALDRKNIREALH 115 Query: 970 LFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLY------GNAVLPEPEIQFK 1023 ++ Y + G + + A Sbjct: 116 DSLKRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRY 175 Query: 1024 DFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKET 1083 E ++ L L + L Sbjct: 176 IGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSC 235 Query: 1084 TRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNT 1143 ++ + ++ + + M Sbjct: 236 LGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAF 295 Query: 1144 LAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLIL 1203 + + Sbjct: 296 VRRQ- 354 Query: 1204 QNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETM 1263 Sbjct: 355 - 413 Query: 1264 IDYLKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLPADQTIHGLFEEQAKR 1322 Sbjct: 414 - 472 Query: 1323 RGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILK 1382 Sbjct: 473 532 Query: 1383 SGGAYLPIDPDYPGERIKFMIEDSGIQLV-----LTQNIPYNWLDFDGEVIDLNCAGLNN 1437 Sbjct: 533 ---- 588 Query: 1438 MDGSNLP--VINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDRERVV 1495 Sbjct: 589 648 Query: 1496 QFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPTYLANL 1555 Sbjct: 649 708 Query: 1556 NPNNIHTVDKMITIGSAISSGLVNEWKRKCEYINAYGPTETTVYSSVWIANKQGEVDDPV 1615 Sbjct: 709 --- 765 Query: 1616 PIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTADKIITAADSRIG 1675 Sbjct: 766 825 Query: 1676 KVYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQ 1735 Sbjct: 826 885 Query: 1736 LQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVP 1795 Sbjct: 886 945 Query: 1796 ENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQ-VAAILGK 1854 Sbjct: 946 1005 Query: 1855 HRLHMEIKDLFHRQKIAELSECV 1877 Sbjct: 1006 1028 Score = 472 bits (1214), Expect = e-132, Method: Compositional matrix adjust. Identities = 0/873 (0%), Positives = 0/873 (0%), Gaps = 41/873 (4%) Query: 1 MSIQNANINVL----LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRL 56 + K+ L R+V + +L + L + Sbjct: 170 AGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVE 229 Query: 57 DIPDGLFQQLQHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYN 116 + + + L +++ + Sbjct: 230 LLAYSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPA 289 Query: 117 HYVPIIDTFT-----TGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFV 171 + + + +T + + + + Sbjct: 290 QM--ALAFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQ--VYTYPA 345 Query: 172 RHVLCLLTNIHNDAVIPDVGSNIVFGFTRDDAGISLNL-----------IYNLKYFTRNF 220 Sbjct: 346 405 Query: 221 VMQLAKQYF----QILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNMEDMTLYEL 276 Sbjct: 406 465 Query: 277 FEKQVRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAG 336 Sbjct: 466 525 Query: 337 GILGILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLDDDV 396 Sbjct: 526 585 Query: 397 LLENESDLDLILGRALDHP---AYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDA 453 Sbjct: 586 -- 643 Query: 454 SDRMLQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPT 513 Sbjct: 644 703 Query: 514 LYSALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLK 573 Sbjct: 704 ------- 756 Query: 574 RDLKPDDTELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLTRDK 633 Sbjct: 757 - 815 Query: 634 FVSNPFEANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLEYNGIT 693 Sbjct: 816 875 Query: 694 EAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTG 753 Sbjct: 876 935 Query: 754 KMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKA 813 Sbjct: 936 995 Query: 814 TMLLSRLHKEFQVEIELDEIFEKQTICNLAALI 846 Sbjct: 996 1028 >all2642 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Length = 346 Score = 667 bits (1721), Expect = 0.0, Method: Compositional matrix adjust. Identities = 0/1097 (0%), Positives = 0/1097 (0%), Gaps = 78/1097 (7%) Query: 845 LIKSKRPGTYS-SILPTEKRDYYPMSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVG 903 RP T + S + + + + + ++ + Sbjct: 53 YPVPPRPETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIRE 112 Query: 904 QVESVLRQMISRHEILRTSFHMIHHEPVQVVHDTIDFSIDYTE-------EKIDDIRLEA 956 + L+++ + + L + R Sbjct: 113 ALHDSLKRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGK 172 Query: 957 DRFIQ-PFDLDTSPLFRVKIIKIASRHYLFMFDMHHIISDGISIGLFIKELALLY----G 1011 R+I + + + + + + + + + Sbjct: 173 IRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLA 232 Query: 1012 NAVLPEPE--IQFKDFSVWEKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKS 1069 + L ++ + + + + P + Sbjct: 233 YSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMA 292 Query: 1070 YEGSKIPFTLDKETTRKLKELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRR 1129 Sbjct: 293 352 Query: 1130 QVELESVMGMFSNTLAMRNFPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVR 1189 Sbjct: 353 412 Query: 1190 DTGRNPLFDAMLILQNIAVNQFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSFE 1249 Sbjct: 413 - 471 Query: 1250 YCTRLFKRETVETMIDYLKAIVNQVIADREIRISDICMVSENAVQQILA-FNQTSFDLPA 1308 Sbjct: 472 531 Query: 1309 DQTIHGLFEEQAKRRGDEPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFE 1368 Sbjct: 532 591 Query: 1369 RSFEMMIGWLGILKSGGAYLPIDPDYPGERIKFMIEDSGIQLVLTQ---------NIPYN 1419 Sbjct: 592 651 Query: 1420 WLDFDGEVIDLNCAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLT 1479 Sbjct: 652 ------- 704 Query: 1480 ASNKEQLKIQDRERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNS 1539 Sbjct: 705 764 Query: 1540 NRITAAILPPTYLANLNPNNIHTVDKMITIGSAISSGLVNEWKRKCEYINAYGPTETTVY 1599 Sbjct: 765 824 Query: 1600 SSVWIANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRP 1659 Sbjct: 825 --- 881 Query: 1660 EMTADKIIT-----AADSRIGK-----------------VYRTGDLARWLPDGNLEYLGR 1697 Sbjct: 882 941 Query: 1698 MDEQVKIRGFRVEPQEIKAELLKIEGIKDVIVTHRKNQLQHASICAYYISAMD------- 1750 Sbjct: 942 1001 Query: 1751 -----------YSVTELRKQLLSKLPEFMIPAYFVRMEAFPLTSNGKIDQKLLPVPENSM 1799 Sbjct: 1002 1061 Query: 1800 QRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDSLKAMQ-VAAILGKHRLH 1858 Sbjct: 1062 - 1120 Query: 1859 MEIKDLFHRQKIAELSE 1875 Sbjct: 1121 1137 Score = 378 bits (970), Expect = e-104, Method: Compositional matrix adjust. Identities = 0/861 (0%), Positives = 0/861 (0%), Gaps = 95/861 (11%) Query: 62 LFQQLQHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEA----YNH 117 Sbjct: 306 365 Query: 118 YVPIIDTFTTGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFVRHVLCL 177 Sbjct: 366 425 Query: 178 LTNIHNDAVIPDVGSNIVFGFTRDDAGISLNLI---------------YNLKYFTRNFVM 222 Sbjct: 426 -- 483 Query: 223 QLAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRT-YQNMEDMTLYELFEKQV 281 Sbjct: 484 543 Query: 282 RQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSIDMAGGILGI 341 Sbjct: 544 603 Query: 342 LKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLK---RDGLTVIRLDDDVLL 398 Sbjct: 604 --------- 654 Query: 399 ENESDLDLILGRALDHP---------AYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEY 449 Sbjct: 655 --- 711 Query: 450 SFDASDRMLQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFI 509 Sbjct: 712 771 Query: 510 AVPTLYSALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVL 569 Sbjct: 772 ------- 824 Query: 570 ATLKRDLKPDDTELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVL 629 Sbjct: 825 - 883 Query: 630 TRDKFV----------------------SNPFEANERMYRTGDLARWTTGGEIEIIGRAD 667 Sbjct: 884 943 Query: 668 TQVKLRGYRIELGEIENRLLEYNGITEAVVALWEDQNDNSRICAYIVCDR---------- 717 Sbjct: 944 1003 Query: 718 --------VLSALELRESLSKSLPEYMLPTHFFQLEQFPMTPTGKMDRNALRNNQDLKEL 769 Sbjct: 1004 - 1062 Query: 770 GARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGGHSLKATMLLSRLHKEFQVEIE 829 Sbjct: 1063 1122 Query: 830 LDEIFEKQTICNLAALIKSKR 850 Sbjct: 1123 1143 Score = 58.9 bits (141), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 17/192 (8%), Positives = 44/192 (22%), Gaps = 16/192 (8%) Query: 1922 HTESIRNAPLVGKHLPAAVQKYHLMNAEKVH---------TSIPFRSCGDIGKIQKAILR 1972 + + +K + + + ++ R Sbjct: 62 QGLTETYVGNWL-AKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 1973 LVNEQVLLRSVIVNDGENTYFYEHGSVYNLPFILIDLSGFDAARRSECLAYLQDHFNKLP 2032 L + + L V F + G +E + + + Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGYS-WTDSAPAVSLLDTLDALAEYQRAGKIRYIGVS 179 Query: 2033 FERDNGLLYRLVLVQTAPEDYMLLYSADHAVSDGLSLGIITDQLAAY---FAGDSSLPVH 2089 E G++ L L ++ +++ + + + S L Sbjct: 180 NETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFG 239 Query: 2090 SLKHHQNYWDYA 2101 +L Y + A Sbjct: 240 TLTGK--YLNGA 249 >RSp0641_7 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Length = 346 Score = 655 bits (1691), Expect = 0.0, Method: Compositional matrix adjust. Identities = 0/1056 (0%), Positives = 0/1056 (0%), Gaps = 67/1056 (6%) Query: 867 PMSSAQKRMYALYHLEGESTSYNMPEVMVMEGELDVGQVESVLRQMISRHEILRTSFHMI 926 S+ + + + + + + + + Sbjct: 6 IPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLT 65 Query: 927 HHEPVQ-VVHDTIDFSIDYTEEKIDDIRLEADR-----------FIQPFDLDTSPLFRVK 974 + + R + + + Sbjct: 66 ETYVGNWLAKHGSREKLIIA-----SKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 975 IIKIASRHYLFMFDMHHIISDGISIGLFIKELALLY-----GNA-VLPEPEIQFKDFSVW 1028 + Y + G + + Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSN 180 Query: 1029 EKESAENGDFKQQEEFWLKMFKGEVPLLELPVDYKRPVHKSYEGSKIPFTLDKETTRKLK 1088 E ++ L L + L Sbjct: 181 ETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGT 240 Query: 1089 ELAGDNGATLYMLLLALFNIMLSKITNQEDIIVGSPVTRRRQVELESVMGMFSNTLAMRN 1148 ++ + ++ + + M + + Sbjct: 241 LTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQ- 299 Query: 1149 FPAGNKRFKDFLNEVKSSALSAFDNQDYQFEEMISKLDIVRDTGRNPLFDAMLILQNI-A 1207 Sbjct: 300 359 Query: 1208 VN-QFQFGEMKVSFYEHEHNISRFDITLHCLEGLDGLLHCSFEYCTRLFKRETVETMIDY 1266 Sbjct: 360 - 418 Query: 1267 LKAIVNQVIADREIRISDICMVSENAVQQIL-AFNQTSFDLPADQTIHGLFEEQAKRRGD 1325 Sbjct: 419 478 Query: 1326 EPALEFLDQTMSYGELNKRANQLARLLREKGVTAGSVVGLMFERSFEMMIGWLGILKSGG 1385 Sbjct: 479 538 Query: 1386 AYLPIDPDYPGERIKFMIEDSGIQLVLTQN----------IPYNWLDFDGEV----IDLN 1431 Sbjct: 539 -- 596 Query: 1432 CAGLNNMDGSNLPVINRSSDLAYMIYTSGTTGKPKGTLLEHKGIVNLTASNKEQLKIQDR 1491 Sbjct: 597 ------------ 644 Query: 1492 ERVVQFSSISFDVSLMDISMSILLGGTLCLTTKEILNDNSCFEAFLNSNRITAAILPPT- 1550 Sbjct: 645 704 Query: 1551 ---YLANLNPNNIHTVDKMITIGSAISSGLVNEWKRK---CEYINAYGPTETTVYSSVWI 1604 Sbjct: 705 764 Query: 1605 ANKQGEVDDPVPIGKPILNTQMYILDKYRNLQPVGIPGELCIGGIGLTRGYWKRPEMTAD 1664 Sbjct: 765 - 823 Query: 1665 KIITAADSRIGK--VYRTGDLARWLPDGNLEYLGRMDEQVKIRGFRVEPQEIKAELLKIE 1722 Sbjct: 824 883 Query: 1723 GIKDVIVTHRKNQLQHASICAYYISAMDYSVTELRKQLLSKLPEFMIPAYFVRMEAFPLT 1782 Sbjct: 884 943 Query: 1783 SNGKIDQKLLPVPENSMQRHSGYIPPRNEIELMLAEVWEEVLRLEKVGIEDNFFEVGGDS 1842 Sbjct: 944 1003 Query: 1843 LKAMQ-VAAILGKHRLHMEIKDLFHRQKIAELSECV 1877 Sbjct: 1004 1039 Score = 475 bits (1222), Expect = e-133, Method: Compositional matrix adjust. Identities = 0/878 (0%), Positives = 0/878 (0%), Gaps = 40/878 (4%) Query: 1 MSIQNANINVL----LSTSEMKKKKKYWLNRVVGSETDSRILTDPHKSALGIEGKESLRL 56 + K+ L R+V + +L + L + Sbjct: 170 AGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVE 229 Query: 57 DIPDGLFQQLQHLSNRSDDSLYYILLTALKWLIVKHTESSIITVASPVYMDENSTSEAYN 116 + + + L +++ + Sbjct: 230 LLAYSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPA 289 Query: 117 HYVPIIDTFT-----TGMTFRESLLQVRETTLGAYDHQDYPFDKIIEDVQAISDRDFSFV 171 + + + +T + + + + Sbjct: 290 QM--ALAFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQ--VYTYPA 345 Query: 172 RHVLCLLTNIHNDAVI------------PDVGS-----NIVFGFTRDDAGISLNLIYNLK 214 Sbjct: 346 405 Query: 215 YFTRNFVMQLAKQYFQILKGAAENVSIKLGSMXXXXXXXXXXXXXXQTRTYQNMEDM-TL 273 Sbjct: 406 465 Query: 274 YELFEKQVRQTPDHVAVKFNNQSITYRDLNAKANKLARVLRNQGVGANQIVGLLVERSID 333 Sbjct: 466 525 Query: 334 MAGGILGILKSGAAYLPLDIKSPEERLQFLIEDAGIEVAVSNKQTEEKLKRDGLTVIRLD 393 Sbjct: 526 -- 583 Query: 394 DDVLLENESDLDLILGRALDHPAYVIYTSGTTGQPKGVIIEHRSISNTIQWRKSEYSFDA 453 Sbjct: 584 643 Query: 454 SDRMLQLFSYIFDGFLTSFFTPIVSGATVVFLDETEARDPLAIIQLITLHKITHFIAVPT 513 Sbjct: 644 703 Query: 514 LYSALLRNMKPEEAQSLRIVTLAGEKVTPNLLIASKQLHPGMEIVNEYGPTESSVLATLK 573 Sbjct: 704 763 Query: 574 R---DLKPDDTELTIGKPIGNTRVYIVGDNLELKAAGMVGELCISGAGLARGYLHNEVLT 630 Sbjct: 764 -- 821 Query: 631 RDKFVSNPF--EANERMYRTGDLARWTTGGEIEIIGRADTQVKLRGYRIELGEIENRLLE 688 Sbjct: 822 881 Query: 689 YNGITEAVVALWEDQNDNSRICAYIVCDRVLSALELRESLSKSLPEYMLPTHFFQLEQFP 748 Sbjct: 882 941 Query: 749 MTPTGKMDRNALRNNQDLKELGARFQHPTNEIESRLVEIWKNVLEVDKVSIHDNFFMLGG 808 Sbjct: 942 1001 Query: 809 HSLKATMLLSRLHKEFQVEIELDEIFEKQTICNLAALI 846 Sbjct: 1002 1039 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.320 0.137 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 171,739,883 Number of extensions: 7385852 Number of successful extensions: 17622 Number of sequences better than 1.0e-05: 298 Number of HSP's gapped: 16248 Number of HSP's successfully gapped: 529 Length of query: 2351 Length of database: 38,378,431 Length adjustment: 123 Effective length of query: 2228 Effective length of database: 24,192,349 Effective search space: 53900553572 Effective search space used: 53900553572 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 124 (52.4 bits)