BLASTP 2.2.18 [Mar-02-2008]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0557.0015.p
         (564 letters)

Database: COG 
           115,334 sequences; 38,378,431 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

MA2454 [R] COG2304 Uncharacterized protein containing a von Will...   679   0.0  

>MA2454 [R] COG2304 Uncharacterized protein containing a von Willebrand
           factor type A (vWA) domain
          Length = 551

 Score =  679 bits (1752), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 331/567 (58%), Positives = 431/567 (76%), Gaps = 21/567 (3%)

Query: 3   MAEKGKKGIILVVIAASV--FALIYFGITLTSNLGKSDKEISAEDAGRKLNKLYKEIDVT 60
           M  +    +IL +I A+V  F L+Y  IT+   +G S+           L+ + ++I+V 
Sbjct: 1   MLNESNNKVILKIIGAAVVVFVLVYLAITI---IGPSEG---------SLDDIIEDINVN 48

Query: 61  VADTVKGQIDLDPA---DIGGSLPDIAKFPVSVDNTTDSFVEIFSSTEKSGTGNDGWLNE 117
                 G + + P     +  +LP+I+ +P  V+N+T +++EIFSSTEK+G+G DGWL E
Sbjct: 49  TVSHPMGHVVISPNLDDSLTENLPEISNYPPQVNNSTPTYIEIFSSTEKAGSGADGWLTE 108

Query: 118 VAAAFNDARIMIGGKQVSVRIRNIASGTATDYIRSGKYIPDAFTPSNELWGEMVKASGTP 177
           VA  FN A I I GKQVSVR+R I SG A DYI SGKY+PDA+TPSNELWGEM+ + G  
Sbjct: 109 VARDFNSAAITIDGKQVSVRLRGIPSGEAADYITSGKYLPDAYTPSNELWGEMIISKGVK 168

Query: 178 AELITKRMTGNVAGVVTNKKKYDELVGKYGSLNVKTITDAIAGNELSMGYTDPFASSTGL 237
           AEL+ +R+ GNVAG++  K K DELV K+G +N KTITDA+A  EL+MGYT+PFASSTGL
Sbjct: 169 AELVQERLVGNVAGILLTKSKKDELVDKHGEINTKTITDAVANKELAMGYTNPFASSTGL 228

Query: 238 NFLVTALGTFDSSDLLSDKAVQGFERFQANVPFIASTTLQMRDAAKTGALDAFVLEYQTY 297
           NFL+++L TFDSS+LLSDKA  GFE FQ N+P +A TTLQMR++AK+G LD FVLEYQTY
Sbjct: 229 NFLISSLYTFDSSNLLSDKAKSGFESFQINIPLVAYTTLQMRESAKSGVLDGFVLEYQTY 288

Query: 298 VNAPDLKSGYVFTPFGVRHDSPLYALGNLPREKEDILHKFAEFAEQDQYQKLAADKGFNG 357
           VN PD++  Y FTPFG RHD+P+YA+G L  EK   L++F EF++Q++YQ L  + GFNG
Sbjct: 289 VNTPDIRY-YEFTPFGFRHDNPMYAIGELSGEKRKTLNEFVEFSQQEKYQTLGTEYGFNG 347

Query: 358 LDDYVSEAAPVEGTLLTSAQKLWKEKKDGSKPIAAVFVADISGSMAGEPLNHLKESLLKG 417
            ++Y SE  PV G ++  AQKLWKEKK   KPI AVFVAD+SGSM GEPLN+LK+SLL+G
Sbjct: 348 FNEYQSETEPVSGDVIFQAQKLWKEKK---KPICAVFVADVSGSMMGEPLNNLKDSLLRG 404

Query: 418 QKFLGKDNSIGFVSYSSEVTINLPIAKYDTNQQSMFVGAINSLQAAGGTATFDGMIVAMK 477
           Q ++G+DN IG VSYS++V I+LPIAK+D NQ++ F GA+N LQA GGTATFDG+ VAMK
Sbjct: 405 QYYIGEDNMIGLVSYSNDVNIDLPIAKFDLNQRASFAGAVNDLQAGGGTATFDGIAVAMK 464

Query: 478 MLQDQLAANPGVKPLIFVLSDGETNEGHSLDEIRGLIETYKIPVYTIGYNANIKALESIS 537
           M+Q+Q AA+P ++P+IFVLSDGETN+GH L++I+G++E   IP+YTIGYNANI AL++IS
Sbjct: 465 MIQEQRAADPNIRPVIFVLSDGETNKGHPLNDIKGIVEDTGIPIYTIGYNANIPALQAIS 524

Query: 538 SINEAANINADTDDVVYKIGNLLNVQM 564
           SINEAA+INADTDDVVYK+GNL N +M
Sbjct: 525 SINEAASINADTDDVVYKLGNLFNAEM 551


  Database: COG
    Posted date:  Aug 3, 2010  9:58 AM
  Number of letters in database: 38,378,431
  Number of sequences in database:  115,334
  
Lambda     K      H
   0.314    0.133    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 115334
Number of Hits to DB: 41,556,875
Number of extensions: 1883693
Number of successful extensions: 2865
Number of sequences better than 1.0e-05: 2
Number of HSP's gapped: 2869
Number of HSP's successfully gapped: 2
Length of query: 564
Length of database: 38,378,431
Length adjustment: 112
Effective length of query: 452
Effective length of database: 25,461,023
Effective search space: 11508382396
Effective search space used: 11508382396
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 118 (50.1 bits)