BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0553.0005.p (280 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH2162 [H] COG1587 Uroporphyrinogen-III synthase 227 2e-59 BS_yjjA [H] COG1587 Uroporphyrinogen-III synthase 224 2e-58 MT0273_1 [H] COG1587 Uroporphyrinogen-III synthase 107 2e-23 Rv0260c_1 [H] COG1587 Uroporphyrinogen-III synthase 107 2e-23 MTH1663 [F] COG2019 Archaeal adenylate kinase 62 1e-09 >BH2162 [H] COG1587 Uroporphyrinogen-III synthase Length = 228 Score = 227 bits (578), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 0/267 (0%), Positives = 0/267 (0%), Gaps = 2/267 (0%) Query: 11 MAEQLQGITVALAGPRKAEEMAKLVQNMGGTALHRPAQGTVF-LDNQALREGIAAWIAHP 69 M + ++ T + Sbjct: 1 MRPAGRSNNQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFL-KGQGQGWI 59 Query: 70 PDLAILTTGMGXXXXXXXXXXXXXXXXXXXVLSASPIAARGYKTVNALKKRGLRPEVRDD 129 + + A R + AL + + + Sbjct: 60 TAEYGMLPRSTHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVL 119 Query: 130 DGSTAGLLRGLEDWDLRGKSVVLQLHGDPAPELAAWLKEAGASVLQVEPYRHTPPEPGAL 189 + + + +L + + A + + Sbjct: 120 QADGGTRTASITGACVALVDALQKLVENGKLKTNPMKGMVAAVSVGIVNGEAVCDLEYVE 179 Query: 190 ARLYEEIAEGRVDAVAFTSAPQFRFLAQYAREQGKLKELVEAFEHKVLAVSVGRITSESL 249 Sbjct: 180 239 Query: 250 KEEGITRIVMPEHERMGSMFVELGKYI 276 Sbjct: 240 266 >BS_yjjA [H] COG1587 Uroporphyrinogen-III synthase Length = 228 Score = 224 bits (570), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 0/265 (0%), Positives = 0/265 (0%) Query: 11 MAEQLQGITVALAGPRKAEEMAKLVQNMGGTALHRPAQGTVFLDNQALREGIAAWIAHPP 70 M + ++ T ++ R Sbjct: 1 MRPAGRSNNQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFLKGQGQGWIT 60 Query: 71 DLAILTTGMGXXXXXXXXXXXXXXXXXXXVLSASPIAARGYKTVNALKKRGLRPEVRDDD 130 + + A R + AL + + + Sbjct: 61 AEYGMLPRSTHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVLQ 120 Query: 131 GSTAGLLRGLEDWDLRGKSVVLQLHGDPAPELAAWLKEAGASVLQVEPYRHTPPEPGALA 190 + + + +L + + A + + Sbjct: 121 ADGGTRTASITGACVALVDALQKLVENGKLKTNPMKGMVAAVSVGIVNGEAVCDLEYVED 180 Query: 191 RLYEEIAEGRVDAVAFTSAPQFRFLAQYAREQGKLKELVEAFEHKVLAVSVGRITSESLK 250 Sbjct: 181 240 Query: 251 EEGITRIVMPEHERMGSMFVELGKY 275 Sbjct: 241 265 >MT0273_1 [H] COG1587 Uroporphyrinogen-III synthase Length = 228 Score = 107 bits (267), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 0/261 (0%), Positives = 0/261 (0%), Gaps = 8/261 (3%) Query: 15 LQGITVALAGPRKAEEMAKLVQNMGGTALHRPAQGTVFL-DNQALREGIAAWIAHPPDLA 73 Q V L ++ G T + A + + + Sbjct: 9 NQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFLKGQGQGWITAEYGMLPR 68 Query: 74 ILTTGMGXXXXXXXXXXXXXXXXXXXVLSASPIAARGYKTVNALKKRGLRPEVRDDDGST 133 T + + + + Sbjct: 69 STHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVLQADGGTRTA 128 Query: 134 AGLLRGLEDWDLRGKSVVLQLHG-----DPAPELAAWLKEAGASVLQVEPYRHTP-PEPG 187 + + D K V ++ + A + Sbjct: 129 SITGACVALVDALQKLVENGKLKTNPMKGMVAAVSVGIVNGEAVCDLEYVEDSAAETDMN 188 Query: 188 ALARLYEEIAEGRVDAVAFTSAPQFRFLAQYAREQGKLKELVEAFEHKVLAVSVGRITSE 247 Sbjct: 189 248 Query: 248 SLKEEGITRIVMPEHERMGSM 268 Sbjct: 249 - 268 >Rv0260c_1 [H] COG1587 Uroporphyrinogen-III synthase Length = 228 Score = 107 bits (267), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 0/261 (0%), Positives = 0/261 (0%), Gaps = 8/261 (3%) Query: 15 LQGITVALAGPRKAEEMAKLVQNMGGTALHRPAQGTVFL-DNQALREGIAAWIAHPPDLA 73 Q V L ++ G T + A + + + Sbjct: 9 NQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFLKGQGQGWITAEYGMLPR 68 Query: 74 ILTTGMGXXXXXXXXXXXXXXXXXXXVLSASPIAARGYKTVNALKKRGLRPEVRDDDGST 133 T + + + + Sbjct: 69 STHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVLQADGGTRTA 128 Query: 134 AGLLRGLEDWDLRGKSVVLQLHG-----DPAPELAAWLKEAGASVLQVEPYRHTP-PEPG 187 + + D K V ++ + A + Sbjct: 129 SITGACVALVDALQKLVENGKLKTNPMKGMVAAVSVGIVNGEAVCDLEYVEDSAAETDMN 188 Query: 188 ALARLYEEIAEGRVDAVAFTSAPQFRFLAQYAREQGKLKELVEAFEHKVLAVSVGRITSE 247 Sbjct: 189 248 Query: 248 SLKEEGITRIVMPEHERMGSM 268 Sbjct: 249 - 268 >MTH1663 [F] COG2019 Archaeal adenylate kinase Length = 268 Score = 62.0 bits (149), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 11/249 (4%), Positives = 34/249 (13%), Gaps = 12/249 (4%) Query: 25 PRKAEEMAKLVQNMGGTALHRPAQGTVFLDNQALREGIAAWIAHPPDLAILTTGMGXXXX 84 + ++ ++ D Sbjct: 7 SIFIPDSLTAETGDLKIKTYKVVLIARAASIFGVKR--IVIYHDDADGEARFI-----RD 59 Query: 85 XXXXXXXXXXXXXXXVLSASPIAARGYKTVNALKKRGLRPEVRDDDGSTAGLLRGLEDWD 144 + G V + + R + Sbjct: 60 ILTYMDTPQYLRRKVFPIMRELKHVGILPPLRTPHHPTGKPVTGEYRQGLTVKRVKKGTL 119 Query: 145 LRGKSVVLQLHGDPAPELAAWLKEAGASVLQVEPYRHTPPE-PGALARLYEEIAEGRVDA 203 + + L L + ++ P + L Sbjct: 120 VDIGADKLALCREKLTVNRIMSFRVVRLGKEILIEPDEPEDRYWGYEVLDTRRNLAESLK 179 Query: 204 VAFTSAPQFRFLAQYAREQGKLKELVEAFEHKVLAVSVGRITSESLKEEGITRIVMPEHE 263 + + V+ + + I + + Sbjct: 180 TVGADVVVATSRNASP--ITSILDEVKTRM-RGAREAAILFGGPYKGLPEID-ADIWVNT 235 Query: 264 RMGSMFVEL 272 G + Sbjct: 236 LPGQCTETV 244 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.316 0.133 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 19,905,274 Number of extensions: 737578 Number of successful extensions: 2529 Number of sequences better than 1.0e-05: 7 Number of HSP's gapped: 2521 Number of HSP's successfully gapped: 7 Length of query: 280 Length of database: 38,378,431 Length adjustment: 105 Effective length of query: 175 Effective length of database: 26,268,361 Effective search space: 4596963175 Effective search space used: 4596963175 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 115 (48.9 bits)