BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0553.0002.p (541 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value MA1861 [R] COG0661 Predicted unusual protein kinase 352 8e-97 alr4515 [R] COG0661 Predicted unusual protein kinase 299 7e-81 sll1770 [R] COG0661 Predicted unusual protein kinase 292 1e-78 alr0189 [R] COG0661 Predicted unusual protein kinase 265 1e-70 sll0095 [R] COG0661 Predicted unusual protein kinase 265 2e-70 >MA1861 [R] COG0661 Predicted unusual protein kinase Length = 559 Score = 352 bits (903), Expect = 8e-97, Method: Compositional matrix adjust. Identities = 187/544 (34%), Positives = 301/544 (55%), Gaps = 13/544 (2%) Query: 3 LMRHGFGYMVEELGLYHLLSLPRRMITQEVHESLTLGE--RIRRVLEDLGPTFVKLGQLA 60 L ++GFGY+V+++GL R+ QE + L R RR+LE+LGPT++KLGQL Sbjct: 22 LQKYGFGYIVDQIGLGSFGDFTSRLKKQEKRDEHNLSGPVRTRRILEELGPTYIKLGQLL 81 Query: 61 STRSDLLPDSIIQELVKLQDSVPPFSAETARNILEQELDQPIDEMFSYFENAPLAAASIG 120 S R DL+P E KLQD P F E I+ +EL P++++F FE PLA ASIG Sbjct: 82 SMRRDLVPLEYAAEFSKLQDDAPSFGFEEVELIIREELGLPVEDLFESFEKKPLACASIG 141 Query: 121 QVHRAVLHGGQSVAVKIQRPGVMRTMTRDLEILQDLSALAERKLDWAKQYGLTRMVEEFS 180 QVHRA L G V VK+QRPG+ + DL+I+ LS L + A+ Y +V+E S Sbjct: 142 QVHRAKLKNGDDVVVKVQRPGIKEVIESDLDIMYSLSRLLTEHIPEARLYRPVELVDELS 201 Query: 181 RALLAELDYGQEGRNAERIAGQLTEHDQVYIPAIFWDYSSTRVLTMEYVEGITLNHREEL 240 R++LAE+DY QEG N +R A + +Q++IP ++WDY+ TRVLT+EY+EGI + L Sbjct: 202 RSILAEIDYSQEGWNTDRFAENFKDSEQIHIPKVYWDYTGTRVLTLEYIEGIKGGRVDLL 261 Query: 241 LLKGVKLKTLAQQLVEMMLNQIFIHGFFHADPHPGNVMLLDDGKLALIDFGMVGRLSEEM 300 +G +A + L Q+F GFFHAD HPGN+++++DG +A +DFGMVG LS E Sbjct: 262 EKQGFDRSAIALAVAGSFLKQVFEDGFFHADLHPGNILIMEDGIVAFLDFGMVGHLSSET 321 Query: 301 KDSLSALVIALMRKNTDSMVRAILRLGVIPEEADRMALHDDMDRLREAYYDIPFKQVSIG 360 +D + A+++ ++ V + +G I D L D D R YY K + Sbjct: 322 RDMFLNGMTAMVKGDSSLFVEVLRDMGGIDSHVDTKVLKVDFDYFRSKYYGRALKNLDAS 381 Query: 361 KALNDLFGIARKHRLVIPPDLAMLGKTMLTLEGVVGNLDPSFSIVQMAEPFGRRLVRQRF 420 + +L + RK+++ +P ++ +L + L +EG +DP ++ ++ EP+ + +++ F Sbjct: 382 VIIEELIEVLRKNQVKVPYNITLLVRGTLAVEGFGLIIDPDLNLAELVEPYAKNAIKESF 441 Query: 421 SGSRLQRKILGGVADLAESLVELPAQARQLSAXXXXXXXXXXXXXXXXXXIEHKVSRVGN 480 + R + ++ + P + + + +++ N Sbjct: 442 YPQNIARVLYDNISSWSRIFQRAPTKISHILDNAENGYLGIKLESEETKRLISEINTASN 501 Query: 481 RLSFSIVLLAFSIIMAGLIIASSLRGEPSM---LWDFPIVEI-GSVIALLMILWLLYSIF 536 RLS FS+I++ +I+ASSL + +M LW P++ I G ++A + +WL+++IF Sbjct: 502 RLS-------FSLIISAIIVASSLITQTNMKPLLWGVPLLGIFGFLLASIFGMWLIFNIF 554 Query: 537 KSGR 540 ++GR Sbjct: 555 RTGR 558 >alr4515 [R] COG0661 Predicted unusual protein kinase Length = 359 Score = 299 bits (766), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 0/411 (0%), Positives = 0/411 (0%), Gaps = 12/411 (2%) Query: 42 IRRVLEDLGPTFVKLGQLASTRSDLLPDSIIQELVKLQDSVPPFSAETARNILEQELDQP 101 L + + + + + +L A R + + QP Sbjct: 94 HFHTAVHNEEQLAALEEASLDEPVTVWMKLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQP 153 Query: 102 IDEMFSYFENAPLAAASIGQVHRAVLHGGQSVAVKIQRPGVMRTMTRDLEILQDLSALAE 161 ++ + + + + + + + + Sbjct: 154 VNIVSHFARADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQSHFDWVRPGII 213 Query: 162 RKLDWAKQYGLTRMVEEFSRALLAELDYGQEGRNAERIAGQLTEHDQVYIPAIFWDYSST 221 + T + + + Sbjct: 214 LYGVSPLEDRSTGADFGCQPVMSLTSSLIAVREHKAGEPVGYGGTWVSERDTRLGVVAMG 273 Query: 222 RVLTMEYVEGITLNHREELLLKGVKLKTLAQQLVEMMLNQIFIHGFFHADPHPGNVMLLD 281 + + + + Q + + Sbjct: 274 YGDGYPRAAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPVILWGEGLPVER 333 Query: 282 DGKLALIDFGMVGRLSEEMKDSLSALVIALMRKNTDSMVRAILRLGVIPEEADRMALHDD 341 Sbjct: 334 393 Query: 342 MDRLREAYYDIPFKQVSIGKALNDLFGIARKHRLVIPPDLAMLGKTMLTLEGVVGNLDPS 401 Sbjct: 394 453 Query: 402 FSIVQMAEPFGRRLVRQRFSGSRLQRKILGGVADLAESLVELPAQARQLSA 452 Sbjct: 454 ------------ 492 >sll1770 [R] COG0661 Predicted unusual protein kinase Length = 585 Score = 292 bits (747), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 149/372 (40%), Positives = 221/372 (59%), Gaps = 1/372 (0%) Query: 42 IRRVLEDLGPTFVKLGQLASTRSDLLPDSIIQELVKLQDSVPPFSAETARNILEQELDQP 101 IR L LGPTF+K+GQL STRSDL P ++EL KLQD VP FS E A I+E+EL +P Sbjct: 88 IRENLLSLGPTFIKVGQLFSTRSDLFPAEYVEELSKLQDEVPAFSYEQAAGIIEEELGKP 147 Query: 102 IDEMFSYFENAPLAAASIGQVHRAVLHGGQSVAVKIQRPGVMRTMTRDLEILQDLSALAE 161 I +++ F+ PLAAAS+GQVH+A LH G+ V VK+QRPG+ + T DL IL+ ++ + Sbjct: 148 IAKLYRSFDPVPLAAASLGQVHKAQLHTGEDVVVKVQRPGLKKLFTIDLAILKKIAQYFQ 207 Query: 162 RKLDWAKQYGLTRMVEEFSRALLAELDYGQEGRNAERIAGQLTEHDQVYIPAIFWDYSST 221 W + + EE + L E DY +EGR+A+ D V +P ++W Y+ST Sbjct: 208 NHPKWGRGRDWNGIYEECCKILWQETDYLREGRSADTFRRNFRGEDWVKVPRVYWRYTST 267 Query: 222 RVLTMEYVEGITLNHREELLLKGVKLKTLAQQLVEMMLNQIFIHGFFHADPHPGNVMLLD 281 ++LT+EY+ GI ++H + L G++ K LAQ L Q+ HGFFHADPHPGN+ + Sbjct: 268 QILTLEYLPGIKISHYDALEAAGLERKELAQLGARAYLFQLLNHGFFHADPHPGNLAVSP 327 Query: 282 D-GKLALIDFGMVGRLSEEMKDSLSALVIALMRKNTDSMVRAILRLGVIPEEADRMALHD 340 + G+L DFGM+G ++ + K+ L + + KN + +V +++ LG + E D + Sbjct: 328 EAGELIFYDFGMMGEITPDTKNKLMDTLFGVAEKNAERIVNSLVALGALKETEDMGPIRR 387 Query: 341 DMDRLREAYYDIPFKQVSIGKALNDLFGIARKHRLVIPPDLAMLGKTMLTLEGVVGNLDP 400 + L + + D PF++ SI K +DL+ IA P + + TLEGV LDP Sbjct: 388 SVQFLLDNFMDKPFEEQSITKISDDLYEIAYDQPFRFPATFTFVMRAFSTLEGVGKGLDP 447 Query: 401 SFSIVQMAEPFG 412 F+ + +A+PF Sbjct: 448 DFNFMAVAQPFA 459 >alr0189 [R] COG0661 Predicted unusual protein kinase Length = 359 Score = 265 bits (677), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 0/554 (0%), Positives = 0/554 (0%), Gaps = 39/554 (7%) Query: 3 LMRHGFGYMVEELGLYHLLSLPRRMIT--QEVHESLTLGERIRRVLEDLGPTFVKLGQLA 60 L R + + + R L D V + A Sbjct: 17 LQRLRELAP-------------ASKMVAVVKANAYGHGLLETARTLPDADAFGVARLEEA 63 Query: 61 STRSDLLPDSIIQELVKLQDSVPPFSAETARNILEQELDQPIDEMFSYFENAPLAAASIG 120 + L D+ + ++ + + + P+ Sbjct: 64 LRLRAGGITKPVLLLEGFFDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMKL 123 Query: 121 QVHRAVLHGGQSVAVKIQRPGVMRTMTRDLEILQDLSALAERKLDWAKQYGLTRMVEEFS 180 L A R + A A+ + F Sbjct: 124 DTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFARADEP-KCGATEKQLAIFNTFC 182 Query: 181 RALLAELDYGQEGRNAERIAGQLT-----EHDQVYIPAIFWDYSSTRVLTMEYVEGITL- 234 + G P + +L Sbjct: 183 EGKPGQRSIAASGGILLWPQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLI 242 Query: 235 ------NHREELLLKGVKLKTLAQQLVEMMLNQIFIHGFFHADPHPGNVMLLDDGKLALI 288 + ++ + G+ A P V++ + Sbjct: 243 AVREHKAGEPVGYGGTWVSERD---TRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVG 299 Query: 289 DFGMVGRLSEEMKDSLSALVIALMRKNTDSMVRAILRLGVIPEEADRMALHDDMDRLREA 348 M + + ++ V I + + L + Sbjct: 300 RVAMDMICVDLGPQAQDKAGDPVILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD 359 Query: 349 YYDIPFKQVSIGKALNDLFGIARKHRLVIPPDLAMLGKTMLTLEGVVGNLDPSFSIVQMA 408 Sbjct: 360 419 Query: 409 EPFGRRLVRQRFSGSRLQRKILGGVADLAESLVELPAQARQLSAXXXXXXXXXXXXXXXX 468 Sbjct: 420 479 Query: 469 XXIEHKVSRVGNRLSFSIVLLAFSIIMAGLIIASSLR-GEPSMLWDFPIVEIGSVIALLM 527 Sbjct: 480 ------- 532 Query: 528 ILWLLYSIFKSGRF 541 Sbjct: 533 546 >sll0095 [R] COG0661 Predicted unusual protein kinase Length = 567 Score = 265 bits (676), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 130/367 (35%), Positives = 218/367 (59%), Gaps = 4/367 (1%) Query: 49 LGPTFVKLGQLASTRSDLLPDSIIQELVKLQDSVPPFSAETARNILEQELDQPIDEMFSY 108 LGPTF+K+GQ STR+D++P I+ +LQD VPPF + A ++EQEL IDE+F Sbjct: 68 LGPTFIKIGQSLSTRADIIPAEYIEAFTQLQDRVPPFDSRQAIAVIEQELHGAIDEIFQQ 127 Query: 109 FENAPLAAASIGQVHRAVLHGGQSVAVKIQRPGVMRTMTRDLEILQDLSALAERKLD--- 165 FE PLA+AS+GQVHRAVL G++V VK+QRPG+ + D E+L LA+R L Sbjct: 128 FEVTPLASASLGQVHRAVLPTGEAVVVKVQRPGLDSLLNLDFELLHQTLRLAKRWLPGFR 187 Query: 166 -WAKQYGLTRMVEEFSRALLAELDYGQEGRNAERIAGQLTEHDQVYIPAIFWDYSSTRVL 224 A++Y + + +EF L E+DY EG+NAER ++ +V +P I+W Y++ VL Sbjct: 188 RLAQKYEIEAIYQEFFSLLFLEIDYIHEGKNAERFRQNFADYPRVRVPEIYWQYTTRMVL 247 Query: 225 TMEYVEGITLNHREELLLKGVKLKTLAQQLVEMMLNQIFIHGFFHADPHPGNVMLLDDGK 284 T+EY+ GI ++ R+ L G+ L + Q + L Q+ + GFF +DPHPGN+ + G Sbjct: 248 TLEYLPGIKVDDRQALETAGINLDLVIQTGICAYLKQLLVDGFFQSDPHPGNMAVDSQGD 307 Query: 285 LALIDFGMVGRLSEEMKDSLSALVIALMRKNTDSMVRAILRLGVIPEEADRMALHDDMDR 344 L DFG + + KD + A++RK+T+ ++ A++ +G++ + D + ++ Sbjct: 308 LIFYDFGTMAEVKIIAKDQMVQTFFAVLRKDTNQVLEALIYMGLVEPKGDLSPIKRIINF 367 Query: 345 LREAYYDIPFKQVSIGKALNDLFGIARKHRLVIPPDLAMLGKTMLTLEGVVGNLDPSFSI 404 L + + D P + + +++ + ++ +PP + + K++ TL+G+ LDP +++ Sbjct: 368 LLDNFRDKPIDIKAFDQVGEEVYAMFQQQPFRLPPQMTFILKSISTLDGIARALDPRYNL 427 Query: 405 VQMAEPF 411 + ++PF Sbjct: 428 IAASQPF 434 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.323 0.139 0.394 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 36,348,108 Number of extensions: 1411232 Number of successful extensions: 11421 Number of sequences better than 1.0e-05: 27 Number of HSP's gapped: 11370 Number of HSP's successfully gapped: 28 Length of query: 541 Length of database: 38,378,431 Length adjustment: 111 Effective length of query: 430 Effective length of database: 25,576,357 Effective search space: 10997833510 Effective search space used: 10997833510 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.5 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (22.0 bits) S2: 118 (50.1 bits)