BLASTP 2.2.18 [Mar-02-2008]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0541.0048.p
         (273 letters)

Database: COG 
           115,334 sequences; 38,378,431 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

mlr1380 [H] COG2243 Precorrin-2 methylase                              86   8e-17
SMc03191 [H] COG2243 Precorrin-2 methylase                             75   8e-14
PAE2573 [H] COG0007 Uroporphyrinogen-III methylase                     54   2e-07
PA2611_2 [H] COG0007 Uroporphyrinogen-III methylase                    52   7e-07

>mlr1380 [H] COG2243 Precorrin-2 methylase
          Length = 162

 Score = 85.5 bits (210), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 0/179 (0%), Positives = 0/179 (0%), Gaps = 15/179 (8%)

Query: 42  GTLYGVGVGPGDPELITLKACRLLRECPVIAYPATKKGGKSYAHEIVEMHIKADEKVMLG 101
                      +      K     +    +      +         +++ +    + +  
Sbjct: 11  AAFATTSAWAAESVQPLEKIAPYPQAEKGMKRQV-IQLTPQEDESTLKVELLIG-QTLEV 68

Query: 102 LVFPMTRD--------PGQLASGWNRTAELCWNELKQGRDVAFVTEGDPNLYSTFIHL-A 152
                            G     +                     +     Y     +  
Sbjct: 69  DCNLHRLGGKLENKTLEGWGYDYYVFDKVSSPVSTMMACPDGKKEKKFVTAYLGDAGMLR 128

Query: 153 RLMQELHPGVPIVSIPGISSVXXXXXXXXXXXXXXDQRVGIIPATEDPEALKEALLHHD 211
              +                                                       
Sbjct: 129 YNSKLP----                                                  183


>SMc03191 [H] COG2243 Precorrin-2 methylase
          Length = 251

 Score = 75.5 bits (184), Expect = 8e-14,   Method: Compositional matrix adjust.
 Identities = 58/176 (32%), Positives = 83/176 (47%), Gaps = 15/176 (8%)

Query: 41  TGTLYGVGVGPGDPELITLKACRLLRECPVIAYPATKKGGKSYAHEIVEMHIKADEKVML 100
           +G L GVG GPGDPEL+T+KA R L E  V+AY A K G       +VE  +K      L
Sbjct: 6   SGRLIGVGTGPGDPELLTVKAVRALGEADVVAYFA-KAGRNGNGRAVVEGLLKPG-MTEL 63

Query: 101 GLVFPMTRD--------PGQLASGWNRTAELCWNELKQGRDVAFVTEGDPNLYSTFIHL- 151
            L +P+T +          Q+   ++ +AE     L  GR VA ++EGDP  Y +++HL 
Sbjct: 64  PLYYPVTTEIDKDHDAYKRQITDFYDASAEAVAAHLLAGRTVAVLSEGDPLFYGSYMHLH 123

Query: 152 ARLMQELHPGVPIVSIPGISSVXXXXXXXXXXXXXXDQRVGIIPATEDPEALKEAL 207
            RL        P   IPGI+++              D  + ++P T     L+  L
Sbjct: 124 VRLAGRF----PAEVIPGITAMSGCWSLAGLPLVQGDDVLSVLPGTMGEGELRRRL 175


>PAE2573 [H] COG0007 Uroporphyrinogen-III methylase
          Length = 228

 Score = 54.3 bits (129), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 9/133 (6%), Positives = 23/133 (17%), Gaps = 26/133 (19%)

Query: 44  LYGVGVGPGDPELITLKACRLLRECPVIAYPATKKGGKSYAHEIVEMHIKADEKVMLGLV 103
             G       P  +T    +      ++ +      G +       +       +     
Sbjct: 3   PAGRSNNQVRPVTLTRNYTKHAEGSVLVEF------GDTKVLCTASIEEGVPRFLKGQGQ 56

Query: 104 FP----MTRDPGQLASGWNRTAELCWNELKQGRDVAFVTEGDPNLYSTFIHLARLMQELH 159
                     P    +   R               A   +           +AR ++   
Sbjct: 57  GWITAEYGMLPRSTHTRNAR--------------EAAKGKQGGRTMEIQRLIARALRA-- 100

Query: 160 PGVPIVSIPGISS 172
                       +
Sbjct: 101 AVDLKALGEFTIT 113


>PA2611_2 [H] COG0007 Uroporphyrinogen-III methylase
          Length = 228

 Score = 52.4 bits (124), Expect = 7e-07,   Method: Compositional matrix adjust.
 Identities = 11/135 (8%), Positives = 20/135 (14%), Gaps = 16/135 (11%)

Query: 39  IGTGTLYGVGVGPGDPELITLKACRLLRECPVIAYPATKKGGKSYAHEIVEMHIKADEKV 98
           +         V P        K                          I E   +  +  
Sbjct: 1   MRPAGRSNNQVRPVTLTRNYTKHAEGSVLVEFGDTK------VLCTASIEEGVPRFLKGQ 54

Query: 99  MLGLVFPMTRDPGQLASGWNRTAELCWNELKQGRDVAFVTEGDPNLYSTFIHLARLMQEL 158
             G          +       T      E  +G+      E    +          +   
Sbjct: 55  GQG------WITAEYGMLPRSTHTRNAREAAKGKQGGRTMEIQRLIARAL---RAAVDLK 105

Query: 159 HP-GVPIVSIPGISS 172
                 I     +  
Sbjct: 106 ALGEFTITLDCDVLQ 120


  Database: COG
    Posted date:  Aug 3, 2010  9:58 AM
  Number of letters in database: 38,378,431
  Number of sequences in database:  115,334
  
Lambda     K      H
   0.316    0.134    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 115334
Number of Hits to DB: 18,298,279
Number of extensions: 744114
Number of successful extensions: 3851
Number of sequences better than 1.0e-05: 4
Number of HSP's gapped: 3850
Number of HSP's successfully gapped: 4
Length of query: 273
Length of database: 38,378,431
Length adjustment: 105
Effective length of query: 168
Effective length of database: 26,268,361
Effective search space: 4413084648
Effective search space used: 4413084648
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 115 (48.9 bits)