BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0535.0021.p (586 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin0617 [V] COG1132 ABC-type multidrug transport system, ATPase ... 459 e-129 Cgl0939 [V] COG1132 ABC-type multidrug transport system, ATPase ... 449 e-126 Rv1272c [V] COG1132 ABC-type multidrug transport system, ATPase ... 407 e-113 MT1310 [V] COG1132 ABC-type multidrug transport system, ATPase a... 407 e-113 TM0288 [V] COG1132 ABC-type multidrug transport system, ATPase a... 405 e-112 >lin0617 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 605 Score = 459 bits (1181), Expect = e-129, Method: Compositional matrix adjust. Identities = 246/547 (44%), Positives = 348/547 (63%), Gaps = 5/547 (0%) Query: 43 PDQLSEMTDLITQGIAA--GIDMEAIASIGLYLVIIYGISAVLSLLQGLIMSSVTQKVSK 100 P +L + T I +G+ + GI+ + I +I + ++++Y S++ S +Q +MSSV Q+ Sbjct: 57 PKELGKATTEIFKGVMSPEGINNDKIFNILMIVLVLYLGSSLFSFIQQYVMSSVAQRTVY 116 Query: 101 RLRGDLSHKMNRLPISYYNKSTTGDILSRVTNDVDTIGQALNQSVGTLVTALSLFVGSIV 160 +R DL KM RLP+ YY+ + GDILSR ND+D I L QS+ +TA+ +G ++ Sbjct: 117 DMRKDLKAKMARLPLKYYDTRSNGDILSRSVNDMDNIANTLQQSLTQAITAIVQMIGVLI 176 Query: 161 MMLKTNWIMTVTAVVATIIGFGLMTVIMKKSQKYFQSQQEYLGKINGHVEEVYTGHTVVK 220 MML +W MT+ +V I L+ +I +SQ+YF +QQ LG +N VEE Y G T++K Sbjct: 177 MMLTISWQMTLIVLVTVPISIILVAIIAGRSQRYFGAQQRNLGILNDTVEETYGGQTIIK 236 Query: 221 AYNAEAQMRGAFEDLNRNLKNSVFKAQFLSGMMMPIMMFIGNLGFVAVCVVGAVLATNGD 280 A+ E + F+++N + + KAQF+SG+MMP+M F+GNLG+V VCV G + TNG Sbjct: 237 AFGQEKKTLVKFDEVNEDYFKAAKKAQFISGIMMPVMQFVGNLGYVGVCVAGGIFVTNGT 296 Query: 281 ISFGVIVAFMMYVRFFTXXXXXXXXXXXXXXXXXXXXKRVFEFLEAEEMDDE-SQKTAQL 339 + G I +F YV+ FT +RVFE ++ EE DE Q+ Sbjct: 297 LQVGDIQSFTQYVQLFTQPISSVANIANIIQSTIASAERVFEMMDEEEEKDEIPANVNQV 356 Query: 340 KAATGKVKFEHVQFAYEGTDNLVIRDFSTEVQPGQKIAIVGPTGAGKTTLVNLLIRFNEL 399 + F+HV+F Y D ++ D + V+ GQ +AIVGPTGAGKTT++NLL+RF ++ Sbjct: 357 AGEEHSIVFDHVKFGYT-PDKPLMTDLNIHVEEGQMVAIVGPTGAGKTTIINLLMRFYDV 415 Query: 400 TGGEIYIDDTPISSLTRENIHDQFCMVLQDTWLFEGTIRENLIYNQTGITDQDIQEACKS 459 GGEI + +T++ + ++F MVLQDTWLF GTI +N+ Y + G T ++ A K+ Sbjct: 416 DGGEIRMRGIDTRDMTKDAVREKFGMVLQDTWLFNGTIADNIAYGREGATKDEVIGAAKA 475 Query: 460 VGLHHFIQTLSAGYDTVLNDK-VNLSAGQKQQLTIARAMLKNAPMLILDEATSSVDTRTE 518 FI+ L GYDT+LN++ N+S GQKQ LTIARA+L + +LILDEATSSVDTRTE Sbjct: 476 AYADDFIRRLPNGYDTILNEEGSNISQGQKQLLTIARAILSDPSILILDEATSSVDTRTE 535 Query: 519 LLIQQAMDRLMEGRTSFVIAHRLSTIKNADVILVLKDGDILESGSHSELLAKNGFYAELY 578 L IQ AM LMEGRTSFVIAHRLSTI++AD+ILV+ G ++E G+H ELL GFYA+LY Sbjct: 536 LNIQLAMGNLMEGRTSFVIAHRLSTIRDADLILVMNHGSVIEQGTHQELLDAKGFYADLY 595 Query: 579 NSQFEQA 585 NSQF A Sbjct: 596 NSQFTGA 602 >Cgl0939 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 656 Score = 449 bits (1154), Expect = e-126, Method: Compositional matrix adjust. Identities = 235/546 (43%), Positives = 355/546 (65%), Gaps = 10/546 (1%) Query: 44 DQLSEMTDL-ITQGIAAGIDMEAIASIGLYLVIIYGISAVLSLLQGLIMSSVTQKVSKRL 102 +Q S M D+ + G +GID E +A I ++ Y I ++LSL Q +++ + Q RL Sbjct: 100 NQASMMEDMNLVPG--SGIDFEKLAMILGLVIGAYLIGSLLSLFQARMLNRIVQSAMHRL 157 Query: 103 RGDLSHKMNRLPISYYNKSTTGDILSRVTNDVDTIGQALNQSVGTLVTALSLFVGSIVMM 162 R ++ K++RLP+SY++ GD+LSRVTNDVD IGQ+L Q++ +T+L +G +VMM Sbjct: 158 RMEVEEKIHRLPLSYFDSIKRGDLLSRVTNDVDNIGQSLQQTLSQAITSLLTVIGVLVMM 217 Query: 163 LKTNWIMTVTAVVATIIGFGLMTVIMKKSQKYFQSQQEYLGKINGHVEEVYTGHTVVKAY 222 + ++ + A+V+ + + V+ +SQK F Q + G +N VEE Y+GH VVK + Sbjct: 218 FIISPLLALVALVSIPVTIVVTVVVASRSQKLFAEQWKQTGILNARVEETYSGHAVVKVF 277 Query: 223 NAEAQMRGAFEDLNRNLKNSVFKAQFLSGMMMPIMMFIGNLGFVAVCVVGAVLATNGDIS 282 + ++ AFE+ N+ + + F AQF+SG++MP MMF+GNL +VA+ VVG + +G +S Sbjct: 278 GHQKDVQEAFEEENQAVYKASFGAQFISGIIMPTMMFVGNLSYVAIAVVGGLQVASGSLS 337 Query: 283 FGVIVAFMMYVRFFTXXXXXXXXXXXXXXXXXXXXKRVFEFLEAEEMDDESQKTAQLKAA 342 G + +F+ Y R FT +RVFE ++ +E D + + + A Sbjct: 338 IGGVQSFIQYSRQFTQPLSQLGSMANLLQSGVASAERVFELIDEDEQDSDPAQPNTVAAG 397 Query: 343 TGKVKFEHVQFAYEGTDNLVIRDFSTEVQPGQKIAIVGPTGAGKTTLVNLLIRFNELTGG 402 +++F+ V F Y D +I + EV+ G IAIVGPTGAGKTTLVNL++RF ++ G Sbjct: 398 ANRLEFKDVSFGYS-EDRPLINNLDLEVRSGSTIAIVGPTGAGKTTLVNLIMRFYDINSG 456 Query: 403 EIYIDDTP-----ISSLTRENIHDQFCMVLQDTWLFEGTIRENLIYNQTGITDQDIQEAC 457 I + +T I ++ RE++ + MVLQDTWLF GTIR+N++Y + T++++ A Sbjct: 457 SITLGETAQDAVDIRTMAREDLRSRTGMVLQDTWLFAGTIRDNILYGRPEATEEEMLAAS 516 Query: 458 KSVGLHHFIQTLSAGYDTVLNDK-VNLSAGQKQQLTIARAMLKNAPMLILDEATSSVDTR 516 K+ + F+++L GYDTVL+D+ +NLS G++Q +TIARA L N +LILDEATSSVDTR Sbjct: 517 KAAYVDRFVRSLPEGYDTVLDDEAMNLSVGERQLITIARAFLANPRLLILDEATSSVDTR 576 Query: 517 TELLIQQAMDRLMEGRTSFVIAHRLSTIKNADVILVLKDGDILESGSHSELLAKNGFYAE 576 TELLIQ+AM +L + RT+FVIAHRLSTI++A++IL++KDG+I+E G+H EL+A G Y E Sbjct: 577 TELLIQRAMSKLRQDRTAFVIAHRLSTIRDANLILMMKDGEIVEQGNHRELMALEGAYWE 636 Query: 577 LYNSQF 582 LYNSQF Sbjct: 637 LYNSQF 642 >Rv1272c [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 631 Score = 407 bits (1045), Expect = e-113, Method: Compositional matrix adjust. Identities = 216/493 (43%), Positives = 309/493 (62%), Gaps = 6/493 (1%) Query: 87 QGLIMSSVTQKVSKRLRGDLSHKMNRLPISYYNKSTTGDILSRVTNDVDTIGQALNQSVG 146 Q +++ QK RLR D+ K++RLP+SY++ G++LSRVTND+D + +L+ ++ Sbjct: 140 QARLLNLTVQKTMVRLRTDVEDKVHRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTIS 199 Query: 147 TLVTALSLFVGSIVMMLKTNWIMTVTAVVATIIGFGLMTVIMKKSQKYFQSQQEYLGKIN 206 LVT++ V + MM+ + ++ + ++ + + I ++SQ F + G++N Sbjct: 200 QLVTSILTMVAVLAMMVSISGLLALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRLN 259 Query: 207 GHVEEVYTGHTVVKAYNAEAQMRGAFEDLNRNLKNSVFKAQFLSGMMMPIMMFIGNLGFV 266 H+EE Y+G TVVK + +A R F +LN ++ + F AQFLSG++ P FIGNLG+V Sbjct: 260 AHLEETYSGFTVVKTFGHQAAARERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGYV 319 Query: 267 AVCVVGAVLATNGDISFGVIVAFMMYVRFFTXXXXXXXXXXXXXXXXXXXXKRVFEFLEA 326 AV V G + G I+ G I AF+ Y+R F +RVF+ L+ Sbjct: 320 AVAVAGGLQVATGQITLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLDE 379 Query: 327 EEMDDESQKTAQLKAATGKVKFEHVQFAY-EGTDNLVIRDFSTEVQPGQKIAIVGPTGAG 385 E + +L TG+V+FEHV FAY GT VIRD S +PG +AIVGPTGAG Sbjct: 380 PEE--SPEPEPELPNLTGRVEFEHVNFAYLPGTP--VIRDLSLVAEPGSTVAIVGPTGAG 435 Query: 386 KTTLVNLLIRFNELTGGEIYIDDTPISSLTRENIHDQFCMVLQDTWLFEGTIRENLIYNQ 445 KTTLVNLL+RF E+ G I ID I+S++R+++ + MVLQDTWL++GTI EN+ Y + Sbjct: 436 KTTLVNLLMRFYEIGSGRILIDGVDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAYGR 495 Query: 446 TGITDQDIQEACKSVGLHHFIQTLSAGYDT-VLNDKVNLSAGQKQQLTIARAMLKNAPML 504 T +I EA ++ + F+ TL AGY T V D ++S G+KQ +TIARA L +L Sbjct: 496 PEATTDEIVEAARAAHVDRFVNTLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQLL 555 Query: 505 ILDEATSSVDTRTELLIQQAMDRLMEGRTSFVIAHRLSTIKNADVILVLKDGDILESGSH 564 ILDEATSSVDTRTELLIQ+AM L RTSF+IAHRLSTI++AD ILV++ G I+E G+H Sbjct: 556 ILDEATSSVDTRTELLIQRAMRELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERGNH 615 Query: 565 SELLAKNGFYAEL 577 +ELLA+ G Y ++ Sbjct: 616 AELLARRGVYYQM 628 >MT1310 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 631 Score = 407 bits (1045), Expect = e-113, Method: Compositional matrix adjust. Identities = 216/493 (43%), Positives = 309/493 (62%), Gaps = 6/493 (1%) Query: 87 QGLIMSSVTQKVSKRLRGDLSHKMNRLPISYYNKSTTGDILSRVTNDVDTIGQALNQSVG 146 Q +++ QK RLR D+ K++RLP+SY++ G++LSRVTND+D + +L+ ++ Sbjct: 140 QARLLNLTVQKTMVRLRTDVEDKVHRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTIS 199 Query: 147 TLVTALSLFVGSIVMMLKTNWIMTVTAVVATIIGFGLMTVIMKKSQKYFQSQQEYLGKIN 206 LVT++ V + MM+ + ++ + ++ + + I ++SQ F + G++N Sbjct: 200 QLVTSILTMVAVLAMMVSISGLLALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRLN 259 Query: 207 GHVEEVYTGHTVVKAYNAEAQMRGAFEDLNRNLKNSVFKAQFLSGMMMPIMMFIGNLGFV 266 H+EE Y+G TVVK + +A R F +LN ++ + F AQFLSG++ P FIGNLG+V Sbjct: 260 AHLEETYSGFTVVKTFGHQAAARERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGYV 319 Query: 267 AVCVVGAVLATNGDISFGVIVAFMMYVRFFTXXXXXXXXXXXXXXXXXXXXKRVFEFLEA 326 AV V G + G I+ G I AF+ Y+R F +RVF+ L+ Sbjct: 320 AVAVAGGLQVATGQITLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLDE 379 Query: 327 EEMDDESQKTAQLKAATGKVKFEHVQFAY-EGTDNLVIRDFSTEVQPGQKIAIVGPTGAG 385 E + +L TG+V+FEHV FAY GT VIRD S +PG +AIVGPTGAG Sbjct: 380 PEE--SPEPEPELPNLTGRVEFEHVNFAYLPGTP--VIRDLSLVAEPGSTVAIVGPTGAG 435 Query: 386 KTTLVNLLIRFNELTGGEIYIDDTPISSLTRENIHDQFCMVLQDTWLFEGTIRENLIYNQ 445 KTTLVNLL+RF E+ G I ID I+S++R+++ + MVLQDTWL++GTI EN+ Y + Sbjct: 436 KTTLVNLLMRFYEIGSGRILIDGVDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAYGR 495 Query: 446 TGITDQDIQEACKSVGLHHFIQTLSAGYDT-VLNDKVNLSAGQKQQLTIARAMLKNAPML 504 T +I EA ++ + F+ TL AGY T V D ++S G+KQ +TIARA L +L Sbjct: 496 PEATTDEIVEAARAAHVDRFVNTLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQLL 555 Query: 505 ILDEATSSVDTRTELLIQQAMDRLMEGRTSFVIAHRLSTIKNADVILVLKDGDILESGSH 564 ILDEATSSVDTRTELLIQ+AM L RTSF+IAHRLSTI++AD ILV++ G I+E G+H Sbjct: 556 ILDEATSSVDTRTELLIQRAMRELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERGNH 615 Query: 565 SELLAKNGFYAEL 577 +ELLA+ G Y ++ Sbjct: 616 AELLARRGVYYQM 628 >TM0288 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 598 Score = 405 bits (1040), Expect = e-112, Method: Compositional matrix adjust. Identities = 210/513 (40%), Positives = 318/513 (61%), Gaps = 3/513 (0%) Query: 71 LYLVIIYGISAVLSLLQGLIMSSVTQKVSKRLRGDLSHKMNRLPISYYNKSTTGDILSRV 130 L L IY ++++L LQG IM +++Q V RLR +L K+ R+P+ +++++ GDI+SRV Sbjct: 81 LILGTIYALTSLLFWLQGKIMLTLSQDVVFRLRKELFEKLQRVPVGFFDRTPHGDIISRV 140 Query: 131 TNDVDTIGQALNQSVGTLVTALSLFVGSIVMMLKTNWIMTVTAVVATIIGFGLMTVIMKK 190 NDVD I L S+ + + G+++MM + N I+++ + + + ++ + Sbjct: 141 INDVDNINNVLGNSIIQFFSGIVTLAGAVIMMFRVNVILSLVTLSIVPLTVLITQIVSSQ 200 Query: 191 SQKYFQSQQEYLGKINGHVEEVYTGHTVVKAYNAEAQMRGAFEDLNRNLKNSVFKAQFLS 250 ++KYF Q LG++NG +EE +G TV+K + E + F+ +N +L+ KAQ S Sbjct: 201 TRKYFYENQRVLGQLNGIIEEDISGLTVIKLFTREEKEMEKFDRVNESLRKVGTKAQIFS 260 Query: 251 GMMMPIMMFIGNLGFVAVCVVGAVLATNGDISFGVIVAFMMYVRFFTXXXXXXXXXXXXX 310 G++ P+M + NLGF + G LA I+ G I F+ Y R FT Sbjct: 261 GVLPPLMNMVNNLGFALISGFGGWLALKDIITVGTIATFIGYSRQFTRPLNELSNQFNMI 320 Query: 311 XXXXXXXKRVFEFLEAEEMDDESQKTAQLKAATGKVKFEHVQFAYEGTDNLVIRDFSTEV 370 +R+FE L+ EE D+ +L+ G+++F++V F+Y+ V++D + + Sbjct: 321 QMALASAERIFEILDLEEEKDDPD-AVELREVRGEIEFKNVWFSYDKKKP-VLKDITFHI 378 Query: 371 QPGQKIAIVGPTGAGKTTLVNLLIRFNELTGGEIYIDDTPISSLTRENIHDQFCMVLQDT 430 +PGQK+A+VGPTG+GKTT+VNLL+RF ++ G+I +D I + R ++ +VLQDT Sbjct: 379 KPGQKVALVGPTGSGKTTIVNLLMRFYDVDRGQILVDGIDIRKIKRSSLRSSIGIVLQDT 438 Query: 431 WLFEGTIRENLIYNQTGITDQDIQEACKSVGLHHFIQTLSAGYDTVLNDK-VNLSAGQKQ 489 LF T++ENL Y G TD++I+EA K HFI+ L GY+TVL D +LS GQ+Q Sbjct: 439 ILFSTTVKENLKYGNPGATDEEIKEAAKLTHSDHFIKHLPEGYETVLTDNGEDLSQGQRQ 498 Query: 490 QLTIARAMLKNAPMLILDEATSSVDTRTELLIQQAMDRLMEGRTSFVIAHRLSTIKNADV 549 L I RA L N +LILDEATS+VDT+TE IQ AM +LMEG+TS +IAHRL+TIKNAD+ Sbjct: 499 LLAITRAFLANPKILILDEATSNVDTKTEKSIQAAMWKLMEGKTSIIIAHRLNTIKNADL 558 Query: 550 ILVLKDGDILESGSHSELLAKNGFYAELYNSQF 582 I+VL+DG+I+E G H EL+ K GFY EL+ SQ+ Sbjct: 559 IIVLRDGEIVEMGKHDELIQKRGFYYELFTSQY 591 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.320 0.134 0.376 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 36,690,054 Number of extensions: 1404941 Number of successful extensions: 22677 Number of sequences better than 1.0e-05: 1569 Number of HSP's gapped: 21135 Number of HSP's successfully gapped: 1629 Length of query: 586 Length of database: 38,378,431 Length adjustment: 112 Effective length of query: 474 Effective length of database: 25,461,023 Effective search space: 12068524902 Effective search space used: 12068524902 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 119 (50.4 bits)