BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0535.0019.p (507 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin0616 [V] COG1132 ABC-type multidrug transport system, ATPase ... 284 3e-76 Cgl0940 [V] COG1132 ABC-type multidrug transport system, ATPase ... 281 1e-75 TM0287 [V] COG1132 ABC-type multidrug transport system, ATPase a... 256 7e-68 MT1311 [V] COG1132 ABC-type multidrug transport system, ATPase a... 244 2e-64 Rv1273c [V] COG1132 ABC-type multidrug transport system, ATPase ... 244 3e-64 >lin0616 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 570 Score = 284 bits (726), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 177/483 (36%), Positives = 262/483 (54%), Gaps = 13/483 (2%) Query: 5 LKYLNPKEWALFGVSFLFIVAQVWLDLELPDYMSEITRLVQTPGSEMSDII-ATGGWMLL 63 +K L P W + QV L LP MS I G +D I +TG MLL Sbjct: 1 MKRLKPY-WLSITAVLVLTFGQVIGQLFLPTLMSNIIDKGVVKGD--TDYIWSTGMQMLL 57 Query: 64 CALGSLATSXXXXXXXXXXXXNFSSRLRSKLFDKVQSFSMEEINNFSTASLITRSTNDIT 123 + S+ S F LR K+F KV+ FS++E + T+SLITR+TND+ Sbjct: 58 ISFASVILSVIVVYLASRISMGFGKDLRDKIFTKVEDFSLQEFDKVGTSSLITRTTNDVV 117 Query: 124 QVQMLIVIGLQLLVKAPILAVWALLKITGKSWEWSLTTXXXXXXXXXXXXXXXXXXXPKF 183 Q+Q ++ + ++L+V API+ + ++ G+ + SL P F Sbjct: 118 QIQNVLYMMMRLMVMAPIMLLGGIIMAVGRDAKLSLIFVVVLPLLLLLVVILGGKAMPMF 177 Query: 184 QKLQQLTDNLNRVSRENLTGLRIIRAYNAEGYQENKFSEANNVLTRTNLFANNVLAVLMP 243 + LQ+ D LNRV RE LTG+R++R++N + KF EAN T + N +L+++ P Sbjct: 178 KSLQKKMDKLNRVIREGLTGIRVVRSFNRNEDELEKFEEANADYATTAIKVNRLLSLMSP 237 Query: 244 SITLIMSGLSLAIYWVGASLIQSADMGAKMGLFSDMIVFSSYAIQVVMAXXXXXXXXXXX 303 + L+M+ S+AI W+G+ I + DM D++ F YA+Q++M+ Sbjct: 238 LMMLLMNLTSIAIVWIGSIFIGNGDMEV-----GDLMAFIQYAMQIMMSFMMLSAVFIMI 292 Query: 304 PRAHVSAKRINEVLDTKPSLMNGSLTASSSKLAGEVEFRKVSFKYPDADDYVLKDISFTA 363 PRA SA+RINEVLD K ++N +S+ A ++ F V+F+Y A+ V++DI+F A Sbjct: 293 PRAGASAERINEVLDMKAEILNPENPKTSTPPA-KLSFEHVTFRYEGAEKPVIEDITFEA 351 Query: 364 KTGETVAFIGSTGCGKSTVVNLIPRFYDATXXXXXXXXXXXXQYEESALRNKMGYVSQKA 423 K GET+A IGSTG GKST++N+IPRFYD + ++S LR K+G V QKA Sbjct: 352 KAGETIAIIGSTGAGKSTLINMIPRFYDVESGVVKINGIDVREMDQSKLRQKIGLVPQKA 411 Query: 424 VLFGGTVTSNIAFGDNGSDASAEVV-DAVYISQASDFVEKMEGSYDAHIAQGGTNLSGGQ 482 VLF GT+ SN+ +G DA+ E + A+ +QA +FV K+ + + QGG N SGGQ Sbjct: 412 VLFTGTIASNMRYGK--EDATDEEIWAALRTAQAENFVSKLANGLGSRVEQGGNNFSGGQ 469 Query: 483 KQR 485 KQR Sbjct: 470 KQR 472 >Cgl0940 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 577 Score = 281 bits (720), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 165/482 (34%), Positives = 253/482 (52%), Gaps = 8/482 (1%) Query: 4 ILKYLNPKEWALFGVSFLFIVAQVWLDLELPDYMSEITRLVQTPGSEMSDIIATGGWMLL 63 ++++L P W L +F +AQ L LP ++I G ++ I TGG ML Sbjct: 6 LVRFLKPA-WPLILTVIIFQLAQSITSLLLPTLNADIIDNGVVTG-DIGYIWHTGGIMLA 63 Query: 64 CALGSLATSXXXXXXXXXXXXNFSSRLRSKLFDKVQSFSMEEINNFSTASLITRSTNDIT 123 L +A + LRS +F KV +FS E+ F SLITR+TND+ Sbjct: 64 LTLVQVACAIAGVYFGSKLSMRVGRDLRSAIFGKVVNFSEREMGQFGAPSLITRNTNDVQ 123 Query: 124 QVQMLIVIGLQLLVKAPILAVWALLKITGKSWEWSLTTXXXXXXXXXXXXXXXXXXXPKF 183 QVQML+ + L++ AP+LA+ ++ + S P F Sbjct: 124 QVQMLVQMTSTLMISAPMLAIGGIIMAVRQDLGLSWLMVVSIPVLIIVVALIIVRMVPLF 183 Query: 184 QKLQQLTDNLNRVSRENLTGLRIIRAYNAEGYQENKFSEANNVLTRTNLFANNVLAVLMP 243 Q +Q+ D +N++ RE LTG+R+IRA+ E + +F+ A+ + + N++A++ P Sbjct: 184 QTMQKRIDRINQIIREQLTGIRVIRAFVREDVERERFTTASKDVADIGVRTGNLMALMFP 243 Query: 244 SITLIMSGLSLAIYWVGASLIQSADMGAKMGLFSDMIVFSSYAIQVVMAXXXXXXXXXXX 303 ++ LIM+ ++A+ W GA ++S + ++G + F Y +Q++M Sbjct: 244 AVMLIMNLSAVAVIWFGAFQVESGE--TQIG---TLFAFLQYIMQILMGVMMAAFMFVMV 298 Query: 304 PRAHVSAKRINEVLDTKPSLMNGSLTASSSKLAGEVEFRKVSFKYPDADDYVLKDISFTA 363 PRA VSA RI EVL+T PS+ A S AGE+ F +F YP ADD VL ++SF Sbjct: 299 PRAAVSADRIGEVLETTPSVQAPETPAQPSTSAGEIVFNNATFAYPGADDPVLNNVSFRV 358 Query: 364 KTGETVAFIGSTGCGKSTVVNLIPRFYDATXXXXXXXXXXXXQYEESALRNKMGYVSQKA 423 G T A IGSTG GK+T++ L+PR +D T ++E L +++G V QK+ Sbjct: 359 APGSTTAIIGSTGSGKTTLIGLVPRLFDVTEGDVTVDGTDVREFEPLKLWDRIGLVPQKS 418 Query: 424 VLFGGTVTSNIAFGDNGSDASAEVVDAVYISQASDFVEKMEGSYDAHIAQGGTNLSGGQK 483 LF GT+ SN+ +G N ++ A+ I+QA+DFV +M D+ IAQGGTN+SGGQ+ Sbjct: 419 FLFSGTIASNLRYG-NEDATETQLWQALAIAQAADFVREMPEGLDSEIAQGGTNVSGGQR 477 Query: 484 QR 485 QR Sbjct: 478 QR 479 >TM0287 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 577 Score = 256 bits (654), Expect = 7e-68, Method: Compositional matrix adjust. Identities = 157/486 (32%), Positives = 250/486 (51%), Gaps = 10/486 (2%) Query: 1 MVKILKYLNPKEWALFGVSFLFIVAQVWLDLELPDYMSEITRLVQTPGSEMSDIIATGGW 60 M + +YL P W ++ LF+V +V DL P ++ I G + S ++ TG Sbjct: 1 MKTLARYLKPY-WIFAVLAPLFMVVEVICDLSQPTLLARIVDEGIARG-DFSLVLKTGIL 58 Query: 61 MLLCALGSLATSXXXXXXXXXXXXNFSSRLRSKLFDKVQSFSMEEINNFSTASLITRSTN 120 ML+ AL NF + LR LF KV SFS+ +N F T+SLITR TN Sbjct: 59 MLIVALIGAVGGIGCTVFASYASQNFGADLRRDLFRKVLSFSISNVNRFHTSSLITRLTN 118 Query: 121 DITQVQMLIVIGLQLLVKAPILAVWALLKITGKSWEWSLTTXXXXXXXXXXXXXXXXXXX 180 D+TQ+Q L+++ L+++V+AP+L V ++ + + S Sbjct: 119 DVTQLQNLVMMLLRIVVRAPLLFVGGIVMAVSINVKLSSVLIFLIPPIVLLFVWLTKKGN 178 Query: 181 PKFQKLQQLTDNLNRVSRENLTGLRIIRAYNAEGYQENKFSEANNVLTRTNLFANNVLAV 240 P F+K+Q+ TD +NRV RENL G+R++RA+ E Y+ F +AN L R+ + A +++ Sbjct: 179 PLFRKIQESTDEVNRVVRENLLGVRVVRAFRREEYENENFRKANESLRRSIISAFSLIVF 238 Query: 241 LMPSITLIMSGLSLAIYWVGASLIQSADMGAKMGLFSDMIVFSSYAIQVVMAXXXXXXXX 300 +P I++ +A+ W G L+++ M ++ +++Y +Q++ + Sbjct: 239 ALPLFIFIVNMGMIAVLWFGGVLVRNNQME-----IGSIMAYTNYLMQIMFSLMMIGNIL 293 Query: 301 XXXPRAHVSAKRINEVLDTKPSLMNGSLTASSSKLAGEVEFRKVSFKYPDADDYVLKDIS 360 RA SAKR+ EVL+ KP++ + + G V F V F+Y + D VL ++ Sbjct: 294 NFIVRASASAKRVLEVLNEKPAIEEADNALALPNVEGSVSFENVEFRYFENTDPVLSGVN 353 Query: 361 FTAKTGETVAFIGSTGCGKSTVVNLIPRFYDATXXXXXXXXXXXXQYEESALRNKMGYVS 420 F+ K G VA +G TG GKST++NLIPR D + LR + V Sbjct: 354 FSVKPGSLVAVLGETGSGKSTLMNLIPRLIDPERGRVEVDELDVRTVKLKDLRGHISAVP 413 Query: 421 QKAVLFGGTVTSNIAFG-DNGSDASAEVVDAVYISQASDFVEKMEGSYDAHIAQGGTNLS 479 Q+ VLF GT+ N+ +G ++ +D E+V+A I+Q DF+ + YD+ + +GG N S Sbjct: 414 QETVLFSGTIKENLKWGREDATD--DEIVEAAKIAQIHDFIISLPEGYDSRVERGGRNFS 471 Query: 480 GGQKQR 485 GGQKQR Sbjct: 472 GGQKQR 477 >MT1311 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 582 Score = 244 bits (623), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 148/431 (34%), Positives = 221/431 (51%), Gaps = 19/431 (4%) Query: 59 GWMLLCALGSLATSXXXXXXXXXXXXNFSSRLRSKLFDKVQSFSMEEINNFSTASLITRS 118 G +LCA+G++ F LRS +F+ + +FS E F +L+TRS Sbjct: 66 GLQVLCAIGAV-------YLGSRTGAGFGRDLRSAMFEHIITFSERETARFGAPTLLTRS 118 Query: 119 TNDITQVQMLIVIGLQLLVKAPILAVWALLKITGKSWEWSLTTXXXXXXXXXXXXXXXXX 178 TND+ Q+ L+ + +LV API+ V ++ + + Sbjct: 119 TNDVRQILFLVQMTATVLVTAPIMCVGGIIMAIHQEAALTWLLLVSVPILAVANYWIISH 178 Query: 179 XXPKFQKLQQLTDNLNRVSRENLTGLRIIRAYNAEGYQENKFSEANNVLTRTNLFANNVL 238 P F+++Q L D +NRV R+ L+G+R++RA+ EGY+ +KF++AN L+ L A N Sbjct: 179 MLPLFRRMQSLIDGINRVMRDQLSGVRVVRAFTREGYERDKFAQANTALSNAALSAGNWQ 238 Query: 239 AVLMPSITLIMSGLSLAIYWVGASLIQSADMGAKMGLFSDMIVFSSYAIQVVMAXXXXXX 298 A+++P TL ++ S+A+ W G I S M ++G +I F SY Q++MA Sbjct: 239 ALMLPVTTLTINASSVALIWFGGLRIDSGQM--QVG---SLIAFLSYFAQILMAVLMATM 293 Query: 299 XXXXXPRAHVSAKRINEVLDTKPSLMN-GSLTASSSKLAGEVEFRKVSFKYPDADDYVLK 357 PRA V A+RI EVL T +L N + + + G V +F YP AD VL+ Sbjct: 294 TLAVLPRASVCAERITEVLSTPAALGNPDNPKFPTDGVTGVVRLAGATFTYPGADCPVLQ 353 Query: 358 DISFTAKTGETVAFIGSTGCGKSTVVNLIPRFYDATXXXXXXXXXXXXQYEESALRNKMG 417 DIS TA+ G T A +GSTG GKST+V+LI R YD T +Y L + +G Sbjct: 354 DISLTARPGTTTAIVGSTGSGKSTLVSLICRLYDVTAGAVLVDGIDVREYHTERLWSAIG 413 Query: 418 YVSQKAVLFGGTVTSNIAFGDNGSD---ASAEVVDAVYISQASDFVEKMEGSYDAHIAQG 474 V Q++ LF GTV N+ +G G D E+ +A+ ++ A FV+ +AQG Sbjct: 414 LVPQRSYLFSGTVADNLRYG-GGPDQVVTEQEMWEALRVAAADGFVQT--DGLQTRVAQG 470 Query: 475 GTNLSGGQKQR 485 G N SGGQ+QR Sbjct: 471 GVNFSGGQRQR 481 >Rv1273c [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Length = 582 Score = 244 bits (622), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 148/431 (34%), Positives = 221/431 (51%), Gaps = 19/431 (4%) Query: 59 GWMLLCALGSLATSXXXXXXXXXXXXNFSSRLRSKLFDKVQSFSMEEINNFSTASLITRS 118 G +LCA+G++ F LRS +F+ + +FS E F +L+TRS Sbjct: 66 GLQVLCAIGAV-------YLGSRTGAGFGRDLRSAMFEHIITFSERETARFGAPTLLTRS 118 Query: 119 TNDITQVQMLIVIGLQLLVKAPILAVWALLKITGKSWEWSLTTXXXXXXXXXXXXXXXXX 178 TND+ Q+ L+ + +LV API+ V ++ + + Sbjct: 119 TNDVRQILFLVQMTATVLVTAPIMCVGGIIMAIHQEAALTWLLLVSVPILAVANYWIISH 178 Query: 179 XXPKFQKLQQLTDNLNRVSRENLTGLRIIRAYNAEGYQENKFSEANNVLTRTNLFANNVL 238 P F+++Q L D +NRV R+ L+G+R++RA+ EGY+ +KF++AN L+ L A N Sbjct: 179 MLPLFRRMQSLIDGINRVMRDQLSGVRVVRAFTREGYERDKFAQANTALSNAALSAGNWQ 238 Query: 239 AVLMPSITLIMSGLSLAIYWVGASLIQSADMGAKMGLFSDMIVFSSYAIQVVMAXXXXXX 298 A+++P TL ++ S+A+ W G I S M ++G +I F SY Q++MA Sbjct: 239 ALMLPVTTLTINASSVALIWFGGLRIDSGQM--QVG---SLIAFLSYFAQILMAVLMATM 293 Query: 299 XXXXXPRAHVSAKRINEVLDTKPSLMN-GSLTASSSKLAGEVEFRKVSFKYPDADDYVLK 357 PRA V A+RI EVL T +L N + + + G V +F YP AD VL+ Sbjct: 294 TLAVLPRASVCAERITEVLSTPAALGNPDNPKFPTDGVTGVVRLAGATFTYPGADCPVLQ 353 Query: 358 DISFTAKTGETVAFIGSTGCGKSTVVNLIPRFYDATXXXXXXXXXXXXQYEESALRNKMG 417 DIS TA+ G T A +GSTG GKST+V+LI R YD T +Y L + +G Sbjct: 354 DISLTARPGTTTAIVGSTGSGKSTLVSLICRLYDVTAGAVLVDGIDVREYHTERLWSAIG 413 Query: 418 YVSQKAVLFGGTVTSNIAFGDNGSD---ASAEVVDAVYISQASDFVEKMEGSYDAHIAQG 474 V Q++ LF GTV N+ +G G D E+ +A+ ++ A FV+ +AQG Sbjct: 414 LVPQRSYLFSGTVADNLRYG-GGPDQVVTEQEMWEALRVAAADGFVQT--DGLQTRVAQG 470 Query: 475 GTNLSGGQKQR 485 G N SGGQ+QR Sbjct: 471 GVNFSGGQRQR 481 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.132 0.371 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 29,189,975 Number of extensions: 1017523 Number of successful extensions: 5126 Number of sequences better than 1.0e-05: 276 Number of HSP's gapped: 4751 Number of HSP's successfully gapped: 285 Length of query: 507 Length of database: 38,378,431 Length adjustment: 111 Effective length of query: 396 Effective length of database: 25,576,357 Effective search space: 10128237372 Effective search space used: 10128237372 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 118 (50.1 bits)