BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0533.0011.p (378 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC1568 [V] COG1680 Beta-lactamase class C and other penicillin b... 164 1e-40 MT1414 [V] COG1680 Beta-lactamase class C and other penicillin b... 137 2e-32 Rv1367c [V] COG1680 Beta-lactamase class C and other penicillin ... 137 3e-32 CC1567 [V] COG1680 Beta-lactamase class C and other penicillin b... 133 5e-31 PA2315 [V] COG1680 Beta-lactamase class C and other penicillin b... 130 3e-30 >CC1568 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 164 bits (416), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 0/336 (0%), Positives = 0/336 (0%), Gaps = 17/336 (5%) Query: 48 PIDDGRIINLYSLTKIMTCTAALQLLEKGAFLLNDRLSDYLPEYTEMNVKKRLPG-GELA 106 I SL + L + E E Sbjct: 91 VQALDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQN 150 Query: 107 FERAVNPITVRDLFTMSAGFSYDL--ELPSIKEAVSRTGGKMPTRAIAEALAKEPLQFEP 164 + ++ + + + LQ Sbjct: 151 YPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLT 210 Query: 165 GTRWNYSLCHDVLAALVEAVDGRRFGTYIREEITGPLGMTDTGFDLPDGKRSRLAPQYEY 224 Sbjct: 211 270 Query: 225 SDELGKPVRKDGNGFRLGTE---YESGGAGLLSTVTDYAQFLNTLTNLGTSPDGVRILSP 281 Sbjct: 271 - 329 Query: 282 ASVELMRTEQLTESM--RGDFSWEQLKGYSYGLGVRTHISQARSGSLSPLGE--FGWSGA 337 Sbjct: 330 --- 386 Query: 338 AGCLAVIDPASQLTVMYAQHMLNNQEPFVHPRLRNI 373 Sbjct: 387 --- 419 >MT1414 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 137 bits (346), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 0/348 (0%), Positives = 0/348 (0%), Gaps = 18/348 (5%) Query: 22 AEVLVMHRNEPVYRYRNGYASLEEKTPIDDGRIINLYSLTKIMTCTAALQLLEKGAFLLN 81 + + Y G + + A Sbjct: 22 ELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPAMIAEARSALPDCQFV 81 Query: 82 DRLSDYLPEYTEMNVKKRLPGGELAFERAVNPITVRDLFTMSAGFSYDLELPSIKEAVSR 141 + +++ + + + L + + Sbjct: 82 EADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQM---PDNWLEPT 138 Query: 142 TGGKMP----TRAIAEALAKEPLQFEPGTRWNYSLCHDVLAALVEAVDGRRFGTYIREEI 197 + + C + I Sbjct: 139 HVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVT 198 Query: 198 TGPLGMTDTGFDLPDGKRSRLAPQYEYSDELGKPVRKDGNGFRLGT--EYESGGAGLLST 255 L + + ++ P++++G Sbjct: 199 ATGLRPWLQDLTESEQQLFLKRYHQMLEEQ--YPLQENGQILLAFPRL 256 Query: 256 VTDYAQFLNTLTNLGTSPDGVRILSPASVELMRTEQLT-ESMRGDFSWEQL-KGYSYGLG 313 Sbjct: 257 - 315 Query: 314 VRTHISQARSGSL---SPLGEFGWSGAAGCLAVIDPASQLTVMY-AQH 357 Sbjct: 316 363 >Rv1367c [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 137 bits (345), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 0/345 (0%), Positives = 0/345 (0%), Gaps = 18/345 (5%) Query: 25 LVMHRNEPVYRYRNGYASLEEKTPIDDGRIINLYSLTKIMTCTAALQLLEKGAFLLNDRL 84 + + + + Y + LL++ Sbjct: 1 MSDWNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITG 60 Query: 85 SDYLPEYTEMNVKKRLPGGELAFERAVNPITVRDLFTMSAGFSYDLELPSIKEAVSRTGG 144 D P + + + L + Sbjct: 61 IDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWL---PDHYELFPHLV 117 Query: 145 KMP----TRAIAEALAKEPLQFEPGTRWNYSLCHDVLAALVEAVDGRRFGTYIREEITGP 200 + A+ + + A + Sbjct: 118 SLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVD 177 Query: 201 LGMTDTGFDLPDGKRSRLAPQYEYSDELGKPVRKDGNGFRLGT--EYESGGAGLLSTVTD 258 + T +P + + +L ++ Sbjct: 178 IWRTTYYHQMPSHQAIIDWVTATGLRP--WLQDLTESEQQLFLKRYHQMLEEQYPLQENG 235 Query: 259 YAQFLNTLTNLGTSPDGVRILSPASVELMRTEQLT-ESMRGDFSWEQL-KGYSYGLGVRT 316 + Sbjct: 236 QILLAFPRLFIVAR- 294 Query: 317 HISQARSGSL---SPLGEFGWSGAAGCLAVIDPASQLTVMY-AQH 357 Sbjct: 295 339 >CC1567 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 133 bits (335), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 0/379 (0%), Positives = 0/379 (0%), Gaps = 28/379 (7%) Query: 24 VLVMHRNEPVYRYRNGYASLEEKTPIDDGRIINLYSLTKIMTCTAALQLLEKGAFLLNDR 83 + ++ N + + Y + + + + + + + E Sbjct: 94 LDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPD 153 Query: 84 LSDYLPEYTEMNVKKRLPGGELAFERAVNPI----TVRDLFTMSAGFSYDL-ELPSIKEA 138 E E + + + + Sbjct: 154 RGREPLAGVHAYYDI---LSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLT 210 Query: 139 VSRTGGKMPTRA----IAEALAKEPLQFEPGTRWNYSLCHDVLAALVEAVDGRRFGTYIR 194 S + Sbjct: 211 ESEQQLFLKRYHQMLE 270 Query: 195 EEITGPLGMTDTGFDLPDGKRSRLAPQYEYSDELGKPVRKDGNGFRLGTEYES---GGAG 251 Sbjct: 271 330 Query: 252 LLSTVTDYAQFLNTLTNLGTSPDGVRILSPASVELMRTEQLTESM------------RGD 299 Sbjct: 331 - 389 Query: 300 FSWEQLKGYSYGLGVRTHISQARSGSLSPLGEFGWSGAAGCLAVIDPASQLTVMYAQHML 359 Sbjct: 390 449 Query: 360 NNQEPFVHPRLRNIVYACL 378 Sbjct: 450 468 >PA2315 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Length = 252 Score = 130 bits (328), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 0/382 (0%), Positives = 0/382 (0%), Gaps = 48/382 (12%) Query: 18 RIPWAEVLVMHRNEPVYRYRNGYASLEEKTPIDDGRIINLYSLTKIMTCTAALQLLEKGA 77 + E + P + + + + Sbjct: 28 PLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRN 87 Query: 78 FLLNDRLSDYLPEYTEMNVKKRLPGGELAFERAVNPITVRDLFTMSAGFSY-----DLEL 132 + L + G + Sbjct: 88 WQPVQALDLIFANA-----SLQWLPDHYEL------FPHLVSLLNPQGVLAVQMPDNWLE 136 Query: 133 PSIKEAVSRTGGKMPTRAIAE---ALAKEPLQFEPGTRWNYSLCHDVLAALVEAVDGRRF 189 P+ + A + + + Sbjct: 137 PTHVLMRE-VAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIID 195 Query: 190 GTYIREEITGPLGMTDTGFDLPDGKR-------SRLAPQYEYSDELGKPVRKDGNGFRL- 241 +T++ L + L + + Sbjct: 196 WVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILLAFPRLF- 254 Query: 242 ------GTEYESGGAGLLSTVTDYAQFLNTLTNLGTSPDGVRILSPASVELMRTEQLTES 295 Sbjct: 255 ------- 307 Query: 296 MRGDFSWEQLKGYSYGLGVRTHISQARSGSLSPLGEFGWSGAAGCLAVIDPASQLTVMYA 355 Sbjct: 308 --- 364 Query: 356 QHML--NNQEPFVHPRLRNIVY 375 Sbjct: 365 - 385 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.136 0.406 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 29,390,347 Number of extensions: 1335723 Number of successful extensions: 2209 Number of sequences better than 1.0e-05: 33 Number of HSP's gapped: 2169 Number of HSP's successfully gapped: 33 Length of query: 378 Length of database: 38,378,431 Length adjustment: 108 Effective length of query: 270 Effective length of database: 25,922,359 Effective search space: 6999036930 Effective search space used: 6999036930 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 117 (49.7 bits)