BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0514.0002.p (1061 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMa0875 [V] COG0841 Cation/multidrug efflux pump 279 2e-74 CC3197 [V] COG0841 Cation/multidrug efflux pump 265 2e-70 YPO2849 [V] COG0841 Cation/multidrug efflux pump 261 6e-69 FN0474 [V] COG0841 Cation/multidrug efflux pump 260 1e-68 all7618 [P] COG3696 Putative silver efflux pump 258 5e-68 >SMa0875 [V] COG0841 Cation/multidrug efflux pump Length = 1065 Score = 279 bits (713), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 251/1035 (24%), Positives = 480/1035 (46%), Gaps = 66/1035 (6%) Query: 37 TIVVVLLMAWGAVSAFQMQRDYLPGINNTTLMVSLRASAYQADQVKRDITTPIEQAIRKT 96 T+++V+++ G S ++ D+ P + ++V+ + + V+ +I+ PIE A+ Sbjct: 15 TMMMVMILVLGLFSYGRLGVDHYPETDLPVVVVATTYTGASPESVESEISRPIEAALNTI 74 Query: 97 NGILNVETTSYDGGLLMNLYYPMNYNMDKAEQDIR--MALGDADLPANVNAPTVTRLTTS 154 GI + + SY+G ++ + + ++ + A Q++R +A + P V P VTR Sbjct: 75 GGIDTITSESYEGRSIVVVQFEVDVDSQDAAQEVRDRVARLETKFPDGVATPQVTRYKPE 134 Query: 155 TFPVLSYSLTANNEKVDDDTLRSTVQAGIVNQLKSVPGVSDVQAVGGAKNGYVVLIHTKD 214 +LS ++++ + + + T +T I N+L + GV V +G ++ +V++ Sbjct: 135 GQAILSVAVSSTSRTLPEITTLAT--RVINNRLSVISGVGQVSLIGSSERQVLVVVDPDR 192 Query: 215 LSAAGLTLDDFNKSVS------AAVPNLQGYIQNVKSPFPVRVEGWDMTEQDVNNIVIKN 268 L A GL + +++ AA + G Q + V VEG N I++ Sbjct: 193 LGAYGLAVSTVIEAIRGENQDRAAGTLISGINQRI-----VTVEGRIANTSGFNRIIVAQ 247 Query: 269 SDGVSVPLSAIASVSRSLNDVQTMSRTDGKASVLINVIKTSGANITDVAKQVKTRVAALP 328 +G V LS +A++ + +V +++ G+ ++ ++++K GAN +VA V+ V+AL Sbjct: 248 RNGYPVYLSEVATILDTGAEVTSLANYQGQTTLGLHIVKVQGANTVEVASAVRREVSALN 307 Query: 329 A-VEGGNVTMTLTGDRAHDLNASLLGLVREGLLGCVFSMLCVLFFFRNVRSTLLIAVSLP 387 A + NV +T+T D + + + + + R + G V S+L V F + RST++ ++LP Sbjct: 308 AELTKDNVQLTITRDNSRPIASQVSQVQRTLVEGGVLSVLIVFIFLNSWRSTVITGLTLP 367 Query: 388 ISLLATTAILKAMGVTLNILTVSGLIVAMGRIVDDAIVILDNMHRKMQEKKDQGALHVLA 447 IS++ T A + A+G TLNI+T+ L +++G ++DDAIV+ +N+ R +Q KD + Sbjct: 368 ISVIGTFAAIYALGFTLNIMTLMALSLSIGILIDDAIVVRENITRHLQMGKD--PVRAAL 425 Query: 448 ESVVEMLPAIFGSTATTVAVYAPIALVGGIIGASYSGFAWSVVIALAVSFLVAMLVIPAF 507 + E+ A+ +T VAV+ P+A +GG+IG + F +V +A+ +S V+ + P Sbjct: 426 DGTNEIGLAVLSTTLCIVAVFLPVAFMGGLIGRFFLQFGVTVAVAVVISLFVSFTLDPML 485 Query: 508 AYMGWHKPGGKAVT------------------LEPAMKPFLTTALKHKKTVLGVSLVIFI 549 + + W P + L + + ++KT + + L +F+ Sbjct: 486 SSV-WCDPQSQKTAKRGFFGQLIERFDQWFEGLASRYRSVIYFTFDYRKTTIAIVLGMFV 544 Query: 550 AAAFFASQLPFSLLPSTASGQVAVQLELPKGTALSEVDKAVQNVETVLKQDSQVAXXXXX 609 + ++ LP G+V++ LE +G +L + V +E L++ + V+ Sbjct: 545 VSLLLVPRIGTEFLPPPDQGEVSISLEANEGASLDYMAAKVGQIERALREFNYVSSTYST 604 Query: 610 XXXXXXPQADDVFDQGGGYIQQPNIANLSVAL--KDQKQVNS--YINSLQERLGNQQGVA 665 G ++ N A ++V L Q+++ + + ++ RL G+ Sbjct: 605 I--------------NSGEMRGFNKALVAVQLVHSSQRRLKTAETLGPIRRRLSRIAGLE 650 Query: 666 AVTITNQNIAGDDSTINIMLSGSDAGTLDKAASTVRSGLAGIEGLSVVGKTDLTNGIPKF 725 + G + + + G L + + + S LA I G + + ++ + P Sbjct: 651 ISVGQRSEVVGSIKPLQLSILGDGDEELRRISDHITSVLAAIPGATEI-ESSIEKLRPTL 709 Query: 726 SIALDRGKVLKAGVSRNDINKVLSRYMTKGKDFDISVSSGTGIIPVDVYLDPVKMGQAQA 785 ++ + R GVS I L R + G + S V V L A Sbjct: 710 AVRVRREAASDLGVSIATIGDTL-RSLVAGDAISVWNSPDGETHDVVVRLPAAGRENAAQ 768 Query: 786 GGPLPVYTPDQVLASLAAETVKGKDGTVYRLDQLGTLQRSDAGSSIQERDGQPYTVVQAR 845 LP+ T A GK V LDQ+ + S A + I +D + + Sbjct: 769 LRNLPIAT--------ARMDDNGKPIMVL-LDQVADVVESTAPAQITRKDLSRDIRISSN 819 Query: 846 IVSSDTSGVSKAVNKVLRTTNLPEGVTYSLGGITQQVTQMIFEMIIAVVLSIFLVLLITS 905 I V + + ++P G S GG + +T+ + ++ +++ + +I + Sbjct: 820 IEGRTLGDVVADLKAAMTKMDIPVGFRISFGGDAENLTESTAYALQSLAMAVIFIYIILA 879 Query: 906 FVFRSWRAPIAVLISIPLALSGVVLALYTVHGQWNLAALIGVLMLTGIVVTNGIVLIDKI 965 F S+ PIA+++++PL+L GV+L L N+ ++IG++ML G+V N I+L+D Sbjct: 880 SQFGSFIQPIAIIMTMPLSLMGVLLGLLFTGSTLNMFSMIGIMMLMGLVTKNAILLVDYS 939 Query: 966 ERNRREGLGLRDAVMQGSLSRVRPIFMTAATTILTLVPLTLSGDDGTVISKVLGVVVIGG 1025 REG LR ++ R+RPI MT I ++P L +G + +IGG Sbjct: 940 NLGVREGKSLRQSLADAGAVRLRPIVMTTLAMIFGMLPTALGLGEGGAQRAPMAHAIIGG 999 Query: 1026 MITSTLNSFVVIPIL 1040 +I+STL S V +P++ Sbjct: 1000 LISSTLLSLVFVPVV 1014 >CC3197 [V] COG0841 Cation/multidrug efflux pump Length = 1041 Score = 265 bits (678), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 266/1063 (25%), Positives = 479/1063 (45%), Gaps = 95/1063 (8%) Query: 18 GMLGMKKWVEAVMQRAAILTIVVVLLMAWGAVSAFQMQRDYLPGINNTTLMVSLRASAYQ 77 G L + W ++ + +V + LM G + + P + + V++ S Sbjct: 13 GQLRVSAWA---IRNPIPVAVVFIALMIAGVGAYLGLPIKQFPNVEFPAVTVTVTQSGAA 69 Query: 78 ADQVKRDITTPIEQAIRKTNGILNVETTSYDGGLLMNLYYPMNYNMDKAEQDIRMALGDA 137 +++ +T PIE A+ + + + ++ G + + + ++ K ++R + A Sbjct: 70 PGEMETQVTRPIEDAVASISNVKTIRSSVVQGASTTTIEFNLGEDLQKVTDEVRSKVDQA 129 Query: 138 D--LPANVNAPTVTRLTTSTFPVLSYSLTANNEKVDDDTLRSTVQAGIVNQLKSVPGVSD 195 LP V+ P V RL ++ P+++Y+++A D L + + L+ GV+ Sbjct: 130 RAVLPREVDEPLVQRLEITSAPIITYAVSAPGMSATD--LSWFIDDTVTRALQGEKGVAQ 187 Query: 196 VQAVGGAKNGYVVLIHTKDLSAAGLTLDDFNK---SVSAAVPNLQGYIQNVKSPFPVRVE 252 V VGG V+I +++ G+T N+ S S P + I + +RV Sbjct: 188 VARVGGVDREINVIIDPDRMASFGVTAPQLNQALASFSVDAPGGRASIGGREQT--LRVL 245 Query: 253 GWDMTEQDVNNIVIKNSDGVSVPLSAIASVSRSLNDVQTMSRTDGKASVLINVIKTSGAN 312 G T + + I I + G V L+ +A V + + + +R DGK V V+KT ++ Sbjct: 246 GAATTIEQLRQITIPVAGGRYVKLTDVAQVGQGSEEERGFARLDGKPVVAFQVMKTRDSS 305 Query: 313 ITDVAKQVKTRVAALPAVEGGNVTMTLTGDRAHDLNASLLGLVREGLLGCVFSMLCVLFF 372 V +VK V L A + VT + AS L G + + L V F Sbjct: 306 DVAVEDRVKAAVDKL-AEKTPGVTFVKIFSTVDETRASFKATEHTLLEGMLLASLVVFLF 364 Query: 373 FRNVRSTLLIAVSLPISLLATTAILKAMGVTLNILTVSGLIVAMGRIVDDAIVILDNMHR 432 R R+TL+ A+++P+SL+ T A + MG +LN++T+ L + +G +VDDA+V ++N+ + Sbjct: 365 LREWRATLITALAMPVSLVPTFAFMAFMGFSLNVVTLLALTLVIGILVDDAVVEIENIEK 424 Query: 433 KMQEKKDQGALHVLAESVVEMLPAIFGSTATTVAVYAPIALVGGIIGASYSGFAWSVVIA 492 ++ + Q E + A+ +T T VAV+ P++ + G+ G + F +V +A Sbjct: 425 RV--ARGQRPFQAAMEGADAIGLAVVATTFTIVAVFVPVSFMPGMPGQFFKEFGLTVAVA 482 Query: 493 LAVSFLVAMLVIPAFAYMGWHKPGGKAVTLEPA-----MKPF-------LTTALKHKKTV 540 + S +VA L+ P A A L+PA KPF L +L H+ Sbjct: 483 VLFSLVVARLLTPLLA----------AYFLKPAKAPHPRKPFEGFYRNILDWSLDHRILA 532 Query: 541 LGVSLVIFIAAAFFASQLPFSLLPSTASGQVAVQLELPKGTALSEVDKAVQNVETVLKQD 600 + +IF+ + A LP + P + ++++ P G ++++D+ VQ V T++++ Sbjct: 533 CIIGGLIFVGSIMLAGLLPTAFQPPANNNYYYLKVQGPPGATVADMDRTVQQVTTLMRK- 591 Query: 601 SQVAXXXXXXXXXXXPQADDVFDQ-----GGGYIQQPNI----ANLSVALKDQKQVNSYI 651 P+ +VF Q G G+ Q + A +++ L+ +++ S Sbjct: 592 --------------RPEVTNVFAQVGSNIGSGWGGQSSADIRDATITIVLRGDREL-SVT 636 Query: 652 NSLQERLGNQQGVAAVTITNQNIAGD--DSTINIMLSGSDAGTLDKAASTVRSGLAGIEG 709 QE + + + + N+ GD S + +L D L++ A+ + + +G Sbjct: 637 EIKQEVRASLRDIPDARV---NLQGDWGSSEVQTILVSEDGPLLERTAAKIEREM---QG 690 Query: 710 LSVVGKTDLTNGIPKFSIALDRGKVLKA---GVSRNDINKVLSRYMTKGKDFDISVSSGT 766 LS V ++ I L R K +A GVS DI + +R T G D D +V+ Sbjct: 691 LSTVADPRPSSPPSGPEI-LIRPKADEAARLGVSSADIAAI-ARVATVG-DIDANVA--- 744 Query: 767 GIIPVDVYLDPVKMGQAQAGGPLPVYTP---DQVLASLAAETVKGKDGTVYRLDQLGTLQ 823 KM Q + P+ V P Q L +L A V +G RLD + L Sbjct: 745 ------------KMTQGERRIPIRVRLPAESRQDLEALGALRVPTANGGSTRLDTVAELS 792 Query: 824 RSDAGSSIQERDGQPYTVVQARIVSSDTSGVSKA-VNKVLRTTNLPEGVTYSLGGITQQV 882 + I + V+A + + G + A V+ + NLP GV + G + Sbjct: 793 FQAGPAKIDRFGRKRQMTVEADLNNGAQLGEAMADVDNLPTMKNLPAGVAPASAGDQEAF 852 Query: 883 TQMIFEMIIAVVLSIFLVLLITSFVFRSWRAPIAVLISIPLALSGVVLALYTVHGQWNLA 942 ++ +A++ ++ LV + +FRS+ PI +L ++PLA+ G L + ++ Sbjct: 853 VELFTGFAVALLSAVGLVFGVLVLLFRSFFKPITILSALPLAIGGAFFGLLVMGQSLSMP 912 Query: 943 ALIGVLMLTGIVVTNGIVLIDKIERNRREGLGLRDAVMQGSLSRVRPIFMTAATTILTLV 1002 +LIG LML G+ N I+L++ R G+ R+A++ R RPI MT + ++ Sbjct: 913 SLIGFLMLMGLAAKNSILLVEYAIEQERAGMSQREAILDACHERARPIVMTTLAMMAGML 972 Query: 1003 PLTLSGDDGTVISKVLGVVVIGGMITSTLNSFVVIPILYEAMN 1045 P L G + + V VIGG+ITST+ S V++P++YE ++ Sbjct: 973 PTALGIGTGAEFRQPMAVAVIGGLITSTVLSLVLVPVVYEIVD 1015 >YPO2849 [V] COG0841 Cation/multidrug efflux pump Length = 1024 Score = 261 bits (666), Expect = 6e-69, Method: Compositional matrix adjust. Identities = 240/1019 (23%), Positives = 471/1019 (46%), Gaps = 68/1019 (6%) Query: 59 LPGINNTTLMVSLRASAYQADQVKRDITTPIEQAIRKTNGILNVETTSYDGGLLMNLYYP 118 LP ++ +MVS + + + TP+E+A+ + G+ + +TS G + L + Sbjct: 37 LPQVDYPVIMVSASMPGADPETMASSVATPLERALGRIAGVNEMTSTSSLGSTRIILQFD 96 Query: 119 MNYNMDKAEQDIRMALGDAD--LPANV-NAPTVTRLTTSTFPVLSYSLTANNEKVDDDTL 175 +N +++ A +D++ AL A LP+ + + PT ++ S P++ +LT++ L Sbjct: 97 LNRDINGAARDVQAALNAAQSLLPSGMPSRPTYRKMNPSDAPIMIMTLTSDT--FSQGQL 154 Query: 176 RSTVQAGIVNQLKSVPGVSDVQAVGGAKNGYVVLIHTKDLSAAGLTLDDFNKSVSAA-VP 234 + ++ GVSDV G + V ++ L G++LD +++SAA V Sbjct: 155 YDYASTKLAQKIAQTEGVSDVTVGGSSLPAVRVELNPSALFNQGVSLDAVRQAISAANVR 214 Query: 235 NLQGYIQNVKSPFPVRVEGWDMTEQDVNNIVIKNSDGVSVPLSAIASVSRSLNDVQTMSR 294 QG + ++ + V+ T + +++ ++G V L +A+V S+ DV+ Sbjct: 215 RPQGSVDAAETHWQVQANDEIKTAEGYRPLIVHYNNGSPVRLQDVANVIDSVQDVRNAGM 274 Query: 295 TDGKASVLINVIKTSGANITDVAKQVKTRVAALPAVEGGNVTMTLTGDRAHDLNASLLGL 354 + G+ +VL+ + + GANI +++ + AL A ++ + + DR+ + ASL + Sbjct: 275 SAGQPAVLLVISREPGANIIATVDRIRAELPALRASIPASIQLNIAQDRSPTIRASLDEV 334 Query: 355 VREGLLGCVFSMLCVLFFFRNVRSTLLIAVSLPISLLATTAILKAMGVTLNILTVSGLIV 414 R ++ +L V F R+ R+TL+ AV++P+SL+ T A + G +LN L++ L + Sbjct: 335 ERSLVIAVALVILVVFIFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTI 394 Query: 415 AMGRIVDDAIVILDNMHRKMQE--KKDQGALHVLAESVVEMLPAIFGSTATTVAVYAPIA 472 A G +VDDAIV+L+N+ R ++ K AL V E+ + + + VAV+ P+ Sbjct: 395 ATGFVVDDAIVVLENISRHLEAGVKPKVAALR----GVREVGFTVLSMSISLVAVFIPLL 450 Query: 473 LVGGIIGASYSGFAWSVVIALAVSFLVAMLVIPAF-AYMGWHKPGGKA----------VT 521 L+ G+ G + FA ++ +A+ +S ++++ + P A++ P G+ + Sbjct: 451 LMAGLPGRLFREFAVTLSVAIGISLVISLTLTPMMCAWLLRSHPKGQQQRIRGFGKVLLA 510 Query: 522 LEPAMKPFLTTALKHKKTVLGVSLVIFIAAAFFASQLPFSLLPSTASGQVAVQLELPKGT 581 ++ L AL H + V+ V L + +P + P +G++ ++ + Sbjct: 511 IQQGYGRSLNWALSHTRWVMVVLLSTIALNVWLYISIPKTFFPEQDTGRMMGFIQADQSI 570 Query: 582 ALSEVDKAVQNVETVLKQDSQVAXXXXXXXXXXXPQADDVFDQGGGYIQQPNIANLSVAL 641 + + + +++ ++ D P D V GG + N ++ ++L Sbjct: 571 SFQSMQQKLKDFMQIVGAD---------------PAVDSVTGFTGG--SRTNSGSMFISL 613 Query: 642 KD----QKQVNSYINSLQERLGNQQGVAAVTITNQNI----AGDDSTINIMLSGSDAGTL 693 K Q+ I L+ +L + G + Q+I ++ L D L Sbjct: 614 KPLSERQETAQQVITRLRGKLAKEPGANLFLSSVQDIRVGGRHSNAAYQFTLLADDLAAL 673 Query: 694 DKAASTVRSGLAGIEGLSVVGKTDLTNGIPKFSIALDRGKVLKAGVSRNDINKVLSRYMT 753 + VR+ LA + L+ V G + ++ DR + + G+ ++ N +L+ Sbjct: 674 REWEPKVRAALAKLPQLADVNSDQQDKGA-EMALTYDRETMARLGIDVSEANALLNNAFG 732 Query: 754 KGKDFDISVSSGTGIIPVDVYLDPVKMGQAQAGGPLPVYTPDQVLASLAAETVKGKDGTV 813 + + IS T P++ Y V M A P YT D ++SL V +G Sbjct: 733 QRQ---IS----TIYQPLNQY--KVVMEVA------PEYTQD--VSSLDKMFVINSNGQS 775 Query: 814 YRLDQLGTLQRSDAGSSIQERDGQPYTVVQARIVSSDT-SGVSKAVNKVLRTTNLPEGVT 872 L Q ++A ++ + + + + + S + AV + + +P V Sbjct: 776 IPLSYFAKWQPANAPLAVNHQGLSAASTISFNLPDGGSLSEATAAVERAMTELGVPSTVR 835 Query: 873 YSLGGITQQVTQMIFEMIIAVVLSIFLVLLITSFVFRSWRAPIAVLISIPLALSGVVLAL 932 + G Q + + + ++ +I V ++ ++ S+ P+ +L ++P A G +LAL Sbjct: 836 GAFAGTAQVFQETLKSQLWLIMAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLAL 895 Query: 933 YTVHGQWNLAALIGVLMLTGIVVTNGIVLID-KIERNRREGLGLRDAVMQGSLSRVRPIF 991 ++L ALIG+++L GIV N I+++D ++ R + R+A+ Q SL R RPI Sbjct: 896 ELFDAPFSLIALIGIMLLIGIVKKNAIMMVDFALDAQRNGNISAREAIFQASLLRFRPII 955 Query: 992 MTAATTILTLVPLTLSGDDGTVISKVLGVVVIGGMITSTLNSFVVIPILYEAMNRKKFR 1050 MT + +PL LS DG + + LG+ ++GG++ S L + P++Y +R + R Sbjct: 956 MTTLAALFGALPLVLSSGDGAELRQPLGITIVGGLVVSQLLTLYTTPVIYLYFDRLRNR 1014 >FN0474 [V] COG0841 Cation/multidrug efflux pump Length = 1012 Score = 260 bits (664), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 226/1036 (21%), Positives = 477/1036 (46%), Gaps = 62/1036 (5%) Query: 24 KWVEAVMQRAAILTIVVVLLMAWGAVSAFQMQRDYLPGINNTTLMVSLRASAYQADQVKR 83 K ++ ++R + T++ + L+ G + M+ + LP I + + S A+ V++ Sbjct: 10 KLIKIAIKRTIVTTMISISLLILGIFAMKSMRTELLPDIEYPVVKIITHWSGASAEDVEK 69 Query: 84 DITTPIEQAIRKTNGILNVETTSYDGGLLMNLYYPMNYNM-DKAEQDIRMALG-DADLPA 141 IT IE+ + GI N+ + S +++ + N+ DK + R DLP Sbjct: 70 QITNKIERILPNVEGIENISSESSYENSSISVEFNYGVNIQDKVTEIQREVFQIKNDLPN 129 Query: 142 NVNAPTVTRLTTSTFPVLSYSLTANNEKVDDDTLRSTVQAGIVNQLKSVPGVSDVQAVGG 201 + P + + + +L D L S ++ + L+++ GV++V +GG Sbjct: 130 SAKNPIIKKTEVGAGAI---TLFLTFVSPDKKALFSYLENYVKPNLETISGVAEVSILGG 186 Query: 202 AKNGYVVLIHTKDLSAAGLT-LDDFN--KSVSAAVPNLQGYIQNVKSPFPVRVEGWDMTE 258 K + I L++ LT +D + + S +P G + N + + ++ G + Sbjct: 187 TKKQLQIQIEPAKLASYNLTPMDIYQLIRKSSMVIP--LGSLMNGREEYVIQALGELESV 244 Query: 259 QDVNNIVIKNSDGVSVPLSAIASVSRSLNDVQTMSRTDGKASVLINVIKTSGANITDVAK 318 ++ NI++ +S+G ++ L IA+V + D + GK + I + K+S + ++ + Sbjct: 245 EEYENILL-HSNGDTLRLKDIANVVLTEEDPLNLGFNRGKPATTIAISKSSDGSTIEINE 303 Query: 319 QVKTRVAALPAVEGGNVTMTLTGDRAHDLNASLLGLVREGLLGCVFSMLCVLFFFRNVRS 378 ++ + + N+T D + + S+ + + L G + + L + FF+N + Sbjct: 304 KIMKAIKNMEETMPSNITYFKIFDSSESIKKSINTVGKSALQGLILASLFLWIFFKNKKM 363 Query: 379 TLLIAVSLPISLLATTAILKAMGVTLNILTVSGLIVAMGRIVDDAIVILDNMHRKMQEKK 438 TL+++ + P+++ T ++K + T N++++ GL + +G + D+++V++DN++ +QE+K Sbjct: 364 TLIVSFAFPLAISTTFILMKGIHSTFNLISLMGLAIGVGMLTDNSVVVIDNIYNHIQEEK 423 Query: 439 DQGALHVLAESVVEMLPAIFGSTATTVAVYAPIALVGGIIGASYSGFAWSVVIALAVSFL 498 + + + ++ ++ ST T++ V+ PI GI + W+++ + + L Sbjct: 424 NSIEAAFIGTN--QVFSSVLASTLTSIIVFLPIIFTKGIFKEMFQDMVWAIIFSNVAALL 481 Query: 499 VAMLVIPAFAYMGWHK-----PGGKAVTLEPAMKPFLTTALKHKKTVLGVSLVI-FIAAA 552 V++ IP A K G ++ + FL+ +LKHKK + +SL+ F+ Sbjct: 482 VSVTFIPMLASKFMKKNIIQTEGKYFSKIQRKYQKFLSISLKHKKKTVLISLLFAFLIFG 541 Query: 553 FFASQLPFSLLPSTASGQVAVQLELPKGTALSEVDKAVQNVETVLKQDSQVAXXXXXXXX 612 + F L G +V E G+ ++ + +ET++K++S Sbjct: 542 IGGKFVKFGFLTKQDYGYYSVIAEFQNGSDFEKIQELRNEIETIIKKESHTKSYF----- 596 Query: 613 XXXPQADDVFDQGGGYIQQPNIANLSVALKDQKQVNSY--INSLQERLGNQQGVAAVTIT 670 + + G I N+ V K++++ + + + +++ + + Sbjct: 597 -------SIIQKRNGTIS----VNVDVGFKEKRKESIFEIVKKVRKEVEKIPDIRTTFFY 645 Query: 671 NQNIAGDDSTINIMLSGSDAGTLDKAASTVRSGLAGIEGLSVVGKTDLTNGIPKFSIALD 730 I + G+D T+ A + + I+G++ V T L +G K I Sbjct: 646 EYAKGKPKKDIEFQIVGTDLETIQILARQIYKDVLKIKGVTDVSST-LDSGGKKLEIIFK 704 Query: 731 RGKVLKAGVSRNDINKVLSRYMTKGKDFD-ISVSSGTGIIPVDVYLDPVKMGQAQAGGPL 789 R K+ +S I + +S Y+ G + I++ SG I V V L Sbjct: 705 RDKIQSLNISIKQIEETISYYLLGGDRANTITIKSGNEEIEVLVRLSK------------ 752 Query: 790 PVYTPDQVLASLAAETVKGKDGTVYRLDQLGTLQRSDAGSSIQERDGQPYTVVQARIVSS 849 + + L +K D + L ++ +++ + SI ++ + Y+V I + Sbjct: 753 ---DNRKSIKQLENLKIKVTDNSFINLSEIADIRKVENQLSI-DKINRFYSV---SIYVN 805 Query: 850 D----TSGVSKAVNKVLRTTNLPEGVTYSLGGITQQVTQMIFEMIIAVVLSIFLVLLITS 905 D T + + + K+ N + Y GG +++ + + E+++ +++IFL+ + + Sbjct: 806 DGGIGTQKIQEELVKIFSEKNKDSSIQYRWGGDAEKMQRAMKELMLTFLIAIFLIYALLA 865 Query: 906 FVFRSWRAPIAVLISIPLALSGVVLALYTVHGQWNLAALIGVLMLTGIVVTNGIVLIDKI 965 F S+ P V+ SIP +L GV++ + A++G+++L GIVV N IVL+D I Sbjct: 866 SQFESFLFPFLVMGSIPFSLVGVIIGFLITQHTLDAVAMVGIILLIGIVVNNAIVLLDFI 925 Query: 966 ERNRREGLGLRDAVMQGSLSRVRPIFMTAATTILTLVPLTLSGDDGTVISKVLGVVVIGG 1025 ++ +E ++A+ + R+RPI +T+ TTI+ ++PL+L DG+ + + LG+ +I G Sbjct: 926 QQEEKESKNKKEAIEKACNLRLRPILLTSLTTIVGMIPLSLGIGDGSEVYQGLGISIIFG 985 Query: 1026 MITSTLNSFVVIPILY 1041 M STL + + +P Y Sbjct: 986 MSFSTLLTLIFVPTTY 1001 >all7618 [P] COG3696 Putative silver efflux pump Length = 1058 Score = 258 bits (658), Expect = 5e-68, Method: Compositional matrix adjust. Identities = 266/1062 (25%), Positives = 486/1062 (45%), Gaps = 93/1062 (8%) Query: 24 KWVEAVMQRAAILTIVVVLLMAWGAVSAFQMQRDYLPGINNTTLMVSLRASAYQADQVKR 83 KW +++QR ++ I +++M G + QM D P + + A ++V+ Sbjct: 7 KW--SIVQRW-LVVIGAMIVMMLGVYNLTQMPLDVFPNFAPPQVEIQTEAPGLAPEEVES 63 Query: 84 DITTPIEQAIRKTNGILNVETTSYDGGLLMNLYYPMNYNMDKAEQDI--RMALGDADLPA 141 +T PIE A+ T G+ V ++S G ++ + + ++ +A Q + R+ LPA Sbjct: 64 LVTLPIESAVNGTPGVETVRSSSGIGISVVRIIFNWGTDIYQARQLVTERLQQASQKLPA 123 Query: 142 NVNAPTVTRLTTSTFPVLSYSLTANNE----KVDDDTLRSTVQAGIVNQLKSVPGVSDVQ 197 N+ +P ++ ++ +L+Y+ T ++ K D +R + + N+L +VPGVS V Sbjct: 124 NIESPQISPISNPIGTILTYAFTIDSPGGKAKTDMMEVRRFIDLVVTNRLLAVPGVSQVI 183 Query: 198 AVGGAKNGYVVLIHTKDLSAAGLTLDDFNKSVSAAVPNLQG-YIQNVKSPFPVRVEGWDM 256 GG Y VL+ L A ++L+D + + A N G ++ + +R G Sbjct: 184 TYGGDVRQYQVLVDPAKLKAFDVSLEDVTTAAAKANNNAAGGFLIDPDQELLIRGIGRIT 243 Query: 257 TEQDVNNIVIKNSDGVSVPLSAIASVSRSLNDVQ---TMSRTDG----KASVLINVIKTS 309 +D+ VI DG V L R + DVQ + R DG + +V++ + K Sbjct: 244 AIEDLQKSVITARDGTPVLL-------RDIADVQIGAALKRGDGSFNTQPAVVVLIDKQP 296 Query: 310 GANITDVAKQVKTRVAALPAVEGGNVTMTLTGDRAHDLNASLLGLVREGLLGCVFSMLCV 369 A+ V++ V+T +A L + NV T+T + + ++ + G + + + Sbjct: 297 QADTPTVSRAVETAIAELKSSLPANVKYTVTFRQESFIEDAIENVTSSLRDGTIIVSIIL 356 Query: 370 LFFFRNVRSTLLIAVSLPISLLATTAILKAMGVTLNILTVSGLIVAMGRIVDDAIVILDN 429 L F N R+ ++ ++P+S+L IL G +N +T+ GL+VA+G +VDD+IV ++N Sbjct: 357 LMFLMNWRTAIITLSAIPLSVLIGMMILNLFGQGINTMTLGGLVVAIGSVVDDSIVDMEN 416 Query: 430 MHRKMQE-KKDQGALH---VLAESVVEMLPAIFGSTATTVAVYAPIALVGGIIGASYSGF 485 +R +QE +K + +H ++ ++ VE+ ++ ST V V+API + GI G ++ Sbjct: 417 CYRGLQENQKAENPVHPFQIVYDTSVEVRTSVILSTVIIVVVFAPIFTLSGIEGRIFAPM 476 Query: 486 AWSVVIALAVSFLVAMLVIPAFAYM---GWHKPGGKAVTL---EPAMKPFLTTALKHKKT 539 W+ ++++ S LVAM + PA + P + + +P L ++K Sbjct: 477 GWAYLVSILSSTLVAMTLSPALCAILLANQRLPDDETWVTRWSQRLYRPLLNFSIKRPSV 536 Query: 540 VLGVSLVIFIAAAFFASQLPFSLLPSTASGQVAVQLELPKGTALSEVDKAVQNVETVLKQ 599 V+ ++ F+A+ S L LP + L L GT+L ++A +E+ LK Sbjct: 537 VILTAIAAFVASMVIFSSLGRVFLPEFQERTLVNSLLLYPGTSLEVTNQAGNAIESALKD 596 Query: 600 DSQVAXXXXXXXXXXXPQADDVFDQGGGYIQQPNIANLSVALKD--QKQVNSYINSLQER 657 D ++A Q G N+ +L + + D K + + ++E Sbjct: 597 DPRIASV----------QMRSGRAPGDADAAPVNLTHLDIEISDVGMKDREATVEKVREE 646 Query: 658 LGNQQG-VAAV-----TITNQNIAGDDSTINIMLSGSDAGTLDKAASTVRSGLAGIEGLS 711 G VAA+ ++ ++G S I + + G + L V + + I GL Sbjct: 647 FARIPGSVAAIGGFISHRMDEILSGVRSAIAVKIFGPELEELRALGKEVEAVMKDIPGLV 706 Query: 712 VVGKTDLTNGIP--KFSIALDRGKVLKAGVSRNDIN---------KVLSRYMTKGKDFDI 760 L IP + I DR + G+S D++ +V+S+ + K + FD+ Sbjct: 707 ---DLQLEPQIPIKQVQIQFDRDAAARYGLSVGDLSEITETALNGRVVSQVLEKQQLFDL 763 Query: 761 SVSSGTGIIPVDVYLDPVKMGQAQAGGPLPVYTPDQVLASLAAETVKGKDGTVYRLDQLG 820 V +L P L V TP++ LAA V ++D G Sbjct: 764 LV-----------WLKPEARNNLDTIRNLLVDTPNEQKIPLAA---------VAKID-YG 802 Query: 821 TLQRSDAGSSIQERDGQPYTVVQARIVSSDTSGVSKAVN-KVLRTTNLPEGVTYSLGGIT 879 T ++I + VV A + D V + KV + +P G GG Sbjct: 803 T-----GPNTINRENVSRLIVVSANVSGRDLGSVVDEIRAKVQQQVQVPSGYFIQYGGQF 857 Query: 880 QQVTQMIFEMIIAVVLSIFLVLLITSFVFRSWRAPIAVLISIPLALSGVVLALYTVHGQW 939 + + +++ LS+ ++ ++ F +S A + ++ ++PLAL G VL++ G Sbjct: 858 ESEQRASQNLLVFGSLSMIVIAVLMYFAVKSIPATLIIMSNLPLALIGGVLSVALGGGIL 917 Query: 940 NLAALIGVLMLTGIVVTNGIVLIDKIERNRREGLGLRDAVMQGSLSRVRPIFMTAATTIL 999 ++A+++G + L G+ NG++L++ G+ LR+ + QGS+ R+ I MTA T+ L Sbjct: 918 SVASMVGFITLFGVATRNGLLLVENYNSKFAIGMPLREVISQGSIERLVAILMTALTSAL 977 Query: 1000 TLVPLTLSGDDGTVISKVLGVVVIGGMITSTLNSFVVIPILY 1041 +VPL + G I + L +VV+GG+ TST + +V+P LY Sbjct: 978 GMVPLVIGTGAGKEILQPLAIVVLGGLFTSTALTLLVLPALY 1019 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.134 0.370 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 71,112,096 Number of extensions: 2842551 Number of successful extensions: 9631 Number of sequences better than 1.0e-05: 131 Number of HSP's gapped: 8966 Number of HSP's successfully gapped: 295 Length of query: 1061 Length of database: 38,378,431 Length adjustment: 117 Effective length of query: 944 Effective length of database: 24,884,353 Effective search space: 23490829232 Effective search space used: 23490829232 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 121 (51.2 bits)