BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0509.0013.p (1052 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin1189 [R] COG2409 Predicted drug exporters of the RND superfamily 780 0.0 CAP0102 [R] COG2409 Predicted drug exporters of the RND superfamily 489 e-138 BS_ydgH [R] COG2409 Predicted drug exporters of the RND superfamily 372 e-102 MT1220 [R] COG2409 Predicted drug exporters of the RND superfamily 118 6e-26 ML1231 [R] COG2409 Predicted drug exporters of the RND superfamily 118 6e-26 >lin1189 [R] COG2409 Predicted drug exporters of the RND superfamily Length = 1066 Score = 780 bits (2015), Expect = 0.0, Method: Compositional matrix adjust. Identities = 431/1059 (40%), Positives = 604/1059 (57%), Gaps = 29/1059 (2%) Query: 1 LKTVLKARWAIIAVWLSAAVVLFMTAPGMSDLVREKGQISVPDGYTSTRAAEIMKEV-AD 59 +K ++K RWAI+A WL+AAVVL AP M+DLVREKG++ +PDGY S+ A E+ K+ D Sbjct: 1 MKWIMKLRWAILAFWLAAAVVLMFIAPPMADLVREKGELKLPDGYPSSLATEMQKKHNPD 60 Query: 60 AKGGETLHQVALVFNKPDGLAAEDTESIKQGVEKLAAEKEALKIDSITDPFSQAELKDTL 119 KG + V+ L + +IK+ ++ + K+ L + ++ F+Q ELKD Sbjct: 61 DKGSAYIA----VYTADHKLTGTELNNIKKSLDSIDKNKDELHVTNVVSSFNQPELKDKF 116 Query: 120 IAKDGKTIMVALMVNGGEEAVKQLPDQVDKLLSGVSADHYLTSEGLITEDTIVSSEAGLK 179 ++KDGKT++ +L V+ + +VK + + +DK + D YLT LI ED + SE GL Sbjct: 117 LSKDGKTMVASLTVDDTDASVKSIRNALDKKMDVKGVDTYLTGNKLIQEDVVQGSEDGLH 176 Query: 180 KSEYITXXXXXXXXXXXXRSFVAPFVPLLTVGLSYIVSQSIVAFLVDRFDFPLSTFTQIF 239 K+E IT RS VAPF+PLLTVG+SY+V+QS VAFL+D F+FP+ST+TQIF Sbjct: 177 KTEGITVVFILVVLFLVFRSAVAPFIPLLTVGISYLVAQSTVAFLIDIFNFPVSTYTQIF 236 Query: 240 MVAVMFGIGTDYCILLISRFKEELATAEDTRSAIISTYRKAGGTVFYSGLAVFVGFLAIG 299 MV +MFGIGTDYCILL+SRFKEE+ D R ++ +TYR AG TV YSG+AV V F ++ Sbjct: 237 MVCIMFGIGTDYCILLMSRFKEEMGAGLDPRESVHATYRTAGKTVIYSGVAVLVAFTSLY 296 Query: 300 LSKFMLYRSAVAVAVGIAVMLLALVTVVPFFMAVLGKKLFWPSSSKLEHSESGIWGAAGS 359 +F LYRSAVAV VGI V+L AL T+VPFFM+ LG LFWP + + H E+ +WGAAG Sbjct: 297 FVQFDLYRSAVAVGVGIVVLLAALYTLVPFFMSTLGTHLFWPLNKNISHKENKVWGAAGK 356 Query: 360 FSLKRPWXXXXXXXXXXXXXXXTYSGKLSFNSMDEIGPGYASVKGFNIISDSFGPGESMP 419 F+ RPW ++G SFNS+DEI Y S KGF I+SDSFG G+ P Sbjct: 357 FTFARPWIALLIVAAITLPPILLHTGTESFNSLDEISDKYPSKKGFEIVSDSFGAGQVAP 416 Query: 420 GKIVIKNDDRMDTSEYMGLAEKISRELEKVDGVKAVRSMSRPTGEQINDFLIPTQVAALT 479 ++ I+NDD M T+EY+ EKIS +L + G+ V S SRP G++++D I Q + Sbjct: 417 TQVFIENDDNMRTTEYIAQIEKISDDLSHLKGIDMVMSASRPAGKRVDDIYIKNQAGQVN 476 Query: 480 DGLSQSNEGLTKIQSGLEEASKQLKGNEPKLNEAVSGSAKLTEGTAELKKGIDALGDGLS 539 DG+ Q+ +G+ +++ GL+ AS +LK +EP L++AV+G L +GT ++GI+ L L+ Sbjct: 477 DGVGQATDGVGEVKKGLDSASSELKKSEPALDKAVAGVGDLQKGTVATEQGINQLQAALA 536 Query: 540 RIERGIKSGSSGAGEIKXXXXXXXXXXXXXXXXXXXXXXGYQKIXXXXXXXXXXX----- 594 +I+ GI+SG++GAG++K GY +I Sbjct: 537 QIQIGIESGATGAGDLKQGVAEAKSQLASLQNGEAQIQAGYAEIQKNLQNVAEQLKGFGN 596 Query: 595 -XXXXXXXXXVASALAGLDASFTGLENAHPDLLQDVNYQT----IKGTVTQSXXXXXXXX 649 + + + SF AHP++ D +Q I+G T Sbjct: 597 PNSPAIDTSKLEAQFKKIGESFQTFAAAHPEVRNDPKFQKLAADIQGLQTAGNELKTTAG 656 Query: 650 XXXXQISGQLKXXXXXXXXXXXXXXXXXXXXXXXXXXLDKLVAGIG-------QLQSGLN 702 + ++K L G+G QL++GLN Sbjct: 657 QQMAALQAKMKELNQGIQQLATAMNQLNEQSKQISDGLSAFGTGLGQIETGLDQLENGLN 716 Query: 703 QAAAGQGQIVDKIPSISSXXXXXXXXXXXXXXXXXXXTGQIGKLTDGLSDSADGLKQITG 762 QAA GQGQ+V K+P IS+ +GQ+G+LT+GL+ ADGL ++ Sbjct: 717 QAADGQGQVVSKMPEISNALSQIAAGQGALKEGFAGISGQMGELTNGLTSGADGLGKVES 776 Query: 763 GLNSAQ---DYLKQIQDAKDDELSGFLVPEEALKEGGIQQVFDNYLSSDRKVMTLDVVYA 819 GLN+A D ++ A SG VP+ LK Q+V D Y+SSD K+ T++V+ Sbjct: 777 GLNTANGLIDDWSKVPYAS----SGIYVPDALLKNADFQKVLDQYISSDGKLATINVILT 832 Query: 820 ANPYSAKAIDSMGDIQAAVDRAVKGTKLENAETAISGVSSTYSDLQKISNEDYTRTXXXX 879 NPYS A+DS+ DI + ++KGTKLENA+ I G++S D + +S DY Sbjct: 833 KNPYSNGAMDSIDDINEQLAASMKGTKLENAKIGIGGMTSANYDTRDMSTADYHLVLVIV 892 Query: 880 XXXXXXXXXXXXRSIIMPLYLIVSLLITYFTALGVTEAIFVHVLDYSGITWTTPFFSFVM 939 RS++MP+YLI SL++TYF ALG E IF+ +L YSG+TW TPFF FV+ Sbjct: 893 LASVFVTLVIVLRSLVMPIYLIASLVLTYFAALGFAEIIFMRILGYSGLTWATPFFGFVV 952 Query: 940 LIALGVDYSIFLMDRFNENKTWDVREAILHAMRNMGTVILSAVVILGGTFASMYPSGVLS 999 L+ALG+DYSIFLM RFNE VR+ ++ AM+NMG VI SAV+ILGGTFA+M P+GVLS Sbjct: 953 LVALGIDYSIFLMSRFNEYNGLSVRDRMIKAMKNMGGVIFSAVIILGGTFAAMMPAGVLS 1012 Query: 1000 MMQIATVVLSGXXXXXXXXXXXXXXXXXXXXGRANWWPF 1038 +++IATVVL G GR NWWPF Sbjct: 1013 LLEIATVVLIGLVLYAIVILPLFVPVMVKLFGRGNWWPF 1051 Score = 52.4 bits (124), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 59/250 (23%), Positives = 103/250 (41%), Gaps = 18/250 (7%) Query: 117 DTLIAKDGKTIMVALMV------NGGEEAVKQLPDQVDKLLSGVSADHYLTSEGLITE-- 168 D I+ DGK + +++ NG +++ + +Q+ + G ++ G +T Sbjct: 815 DQYISSDGKLATINVILTKNPYSNGAMDSIDDINEQLAASMKGTKLENAKIGIGGMTSAN 874 Query: 169 -DTIVSSEAGLKKSEYITXXXXXXXXXXXXRSFVAPFVPLLTVGLSYIVSQSIVAFLVDR 227 DT S A I RS V P + ++ L+Y + + R Sbjct: 875 YDTRDMSTADYHLVLVIVLASVFVTLVIVLRSLVMPIYLIASLVLTYFAALGFAEIIFMR 934 Query: 228 F--DFPLSTFTQIFMVAVMFGIGTDYCILLISRFKEELATAEDTRSAIISTYRKAGGTVF 285 L+ T F V+ +G DY I L+SRF E R +I + GG +F Sbjct: 935 ILGYSGLTWATPFFGFVVLVALGIDYSIFLMSRFNE--YNGLSVRDRMIKAMKNMGGVIF 992 Query: 286 YSGLAVFVGFLAIGLSKFMLYRSAVAVAVGIAVMLLALVTV---VPFFMAVLGKKLFWPS 342 S + + G A + +L +A V I ++L A+V + VP + + G+ +WP Sbjct: 993 -SAVIILGGTFAAMMPAGVLSLLEIATVVLIGLVLYAIVILPLFVPVMVKLFGRGNWWPF 1051 Query: 343 -SSKLEHSES 351 + K +H E+ Sbjct: 1052 ITRKGDHQEN 1061 >CAP0102 [R] COG2409 Predicted drug exporters of the RND superfamily Length = 1058 Score = 489 bits (1260), Expect = e-138, Method: Compositional matrix adjust. Identities = 308/1024 (30%), Positives = 508/1024 (49%), Gaps = 35/1024 (3%) Query: 1 LKTVLKARWAIIAVWLSAAVVLFMTAPGMSDLVREKGQISVPDGYTSTRAAEIMKEVADA 60 L +L + I W V+ T P M LVR+KGQ+++ Y+ + A I+ ++ D Sbjct: 9 LNKLLNKSYLSIVFWALILTVILFTMPDMGKLVRDKGQVTIGKEYSYSTAQNILNKLNDV 68 Query: 61 KGGETLHQVALVFNKPDGLAAEDTESIKQGVEKLAAEKEALKIDSITDPFSQAELKDTLI 120 K + + V +V++ L IK V KL K + ++ + F+ +++D +I Sbjct: 69 KSSDKVLDVIMVYHSDKKLTDSALNEIKDKVTKLENNKNKYNVKTVLNVFTNKDIEDQVI 128 Query: 121 AKDGKTIMVALMVNGGEEAVKQLPDQVDKLLSGVSADHYLTSEGLITEDTIVSSEAGLKK 180 +KD T++V + + + + +++ K++ Y T I+ED + EAG+KK Sbjct: 129 SKDKTTLLVPISIKQKGRTTETIRNEITKVMKTDKVTSYSTGSDFISEDFSKTIEAGVKK 188 Query: 181 SEYITXXXXXXXXXXXXRSFVAPFVPLLTVGLSYIVSQSIVAFLVDRFDFPLSTFTQIFM 240 +E IT +S V PF L TVGLSY+ S IV LVD+F+F +S FT +F+ Sbjct: 189 TELITIFLIIAILIAVFKSPVTPFATLATVGLSYLTSLGIVLQLVDKFNFSISNFTNVFL 248 Query: 241 VAVMFGIGTDYCILLISRFKEELATAEDTRSAIISTYRKAGGTVFYSGLAVFVGFLAIGL 300 V V+FGIGTDY +LL++RFKEEL DT SAII TY+ AG TV S L + +GF + Sbjct: 249 VLVLFGIGTDYTMLLLTRFKEELNNGLDTNSAIIVTYKTAGKTVILSSLTILIGFSCLMA 308 Query: 301 SKFMLYRSAVAVAVGIAVMLLALVTVVPFFMAVLGKKLFWPSSSKLEHSESGIWGAAGSF 360 S+F +Y+SA AVAVG+AV+++ + T +P M + G LFW HS + W A + Sbjct: 309 SQFKIYQSASAVAVGVAVLIIMIFTFLPALMKLFGIHLFWSPFKSSGHSSNKAWEKAATI 368 Query: 361 SLKRPWXXXXXXXXXXXXXXXTYSGKLSFNSMDEIGPGYASVKGFNIISDSFGPGESMPG 420 S K P+ Y+ LSFN++ EI Y SVKGFNI+S FG G+++P Sbjct: 369 STKYPFFALILVLAVCGLSYF-YTSSLSFNNLKEIASNYPSVKGFNIVSKHFGVGKALPV 427 Query: 421 KIVIKNDDRMDTSEYMGLAEKISRELEKVDGVKAVRSMSRPTGEQINDFLIPTQVAALTD 480 + I+ND R+D + ++I+ ++ V GVK V S+++P G++I D I Q +L Sbjct: 428 NVAIENDYRLDNQYTLSEIDEITEAIKSVKGVKEVCSVTQPKGKKIKDLYIKDQANSLNG 487 Query: 481 GLSQSNEGLTKIQSGLEEASKQLKGNEPKLNEAVSGSAKLTEGTAELKKGIDALGDGLSR 540 GL ++ G+ KI +GL +A +L+G + N KL +G +L +D + + Sbjct: 488 GLKDADGGVNKINNGLGDAVSKLQGAKVDTNSL----DKLQKGANDLSSNMDLINKATNE 543 Query: 541 IERGIKSGSSGAGEIKXXXXXXXXXXXXXXXXXXXXXXGYQKIXXXXXXXXXXXXXXXXX 600 ++ G+ SG G+ ++ Y I Sbjct: 544 LKNGMNSGVQGSKDLSNGIQALDDSIGKLQDSTNDLQNAYTAIGKGYGQVGEGLNSLLPQ 603 Query: 601 XXXVASALAGLDASFTGLENAHPDLLQDVNYQTIKGTVTQSXXXXXXXXXXXXQISGQLK 660 +A + + L HP+L D + T++ T +++ +L+ Sbjct: 604 VKNFQTAFGSVIYMQSQLAAKHPELNSDPTFVTMQQT--------------SLKLNSKLQ 649 Query: 661 XXXXXXXXXXXXXXXXXXXXXXXXXXLDKLVAGIGQLQSG--------------LNQAAA 706 L + +GIG ++SG L +AA Sbjct: 650 DMVDAITKLKAGLDEANSSLKKANNGLSQAQSGIGAMKSGSEALRSGSLTMANKLAEAAD 709 Query: 707 GQGQIVDKIPSISSXXXXXXXXXXXXXXXXXXXTGQIGKLTDGLSDSADGLKQITGGLNS 766 GQ ++ + + + + + +LTDGLS + GL I+ GLN Sbjct: 710 GQNKVANAMGQLDEGSKQLQDGQNQLINGISGISDKTKQLTDGLSTAQKGLTDISTGLND 769 Query: 767 AQDYLKQIQDAKDDELSGFLVPEEALKEGGIQQVFDNYLSSDRKVMTLDVVYAANPYSAK 826 A Y+ ++Q +K+ E F +P++ + + D Y+S DRK+ ++V +PYS Sbjct: 770 ANSYIDKLQKSKNSE--TFFIPQDKINNSDFSKSMDMYMSKDRKITEINVTLNIDPYSED 827 Query: 827 AIDSMGDIQAAVDRAVKGTKLENAETAISGVSSTYSDLQKISNEDYTRTXXXXXXXXXXX 886 A+ I + V +K + L+N++ ISG+S +DL+ +S +D+ ++ Sbjct: 828 AMKITDKINSVVAAKIKTSTLKNSKLGISGISQMNNDLKTMSQKDFNKSSIIMICGILIV 887 Query: 887 XXXXXRSIIMPLYLIVSLLITYFTALGVTEAIFVHVLDYSGITWTTPFFSFVMLIALGVD 946 R M ++++ SL+ +Y+ A+ ++ +F +VL ++W PFFSF+M+I+LGVD Sbjct: 888 LLIVTRDSWMSIFIMASLVASYYIAISISGLLFNNVLGKGDLSWNVPFFSFIMIISLGVD 947 Query: 947 YSIFLMDRFNENKTWDVREAILHAMRNMGTVILSAVVILGGTFASMYPSGVLSMMQIATV 1006 YSIFL+ R+ EN +EAI+ A +++G VI SA +IL GTFA+MYPSGV ++M+++ Sbjct: 948 YSIFLVMRYRENLDLPSKEAIVSAAKSVGGVISSAGIILSGTFAAMYPSGVPTLMELSLT 1007 Query: 1007 VLSG 1010 V+ G Sbjct: 1008 VILG 1011 >BS_ydgH [R] COG2409 Predicted drug exporters of the RND superfamily Length = 314 Score = 372 bits (955), Expect = e-102, Method: Compositional matrix adjust. Identities = 0/510 (0%), Positives = 0/510 (0%), Gaps = 13/510 (2%) Query: 1 LKTVLKARWAIIAVWLSAAVVLFMTAPGMSDLVREKGQISVPDGYTSTRAAEIMKEVADA 60 +K + + ++ +V + V G + + Sbjct: 1 MKLKNTLLASALLSAMAFSVNAATELTPEQAAAVKPFDRVVVTGRFNAIGEAVKAV---- 56 Query: 61 KGGETLHQVALVFNKPDGLAAEDTESIKQGVEKLAAEKEALKIDSITDPFS-QAELKDTL 119 + A F D ++ + + K + T ++ Sbjct: 57 -SRRADKEGAASFYVVDTSDFGNSGNWRV---VADLYKADAEKAEETSNRVINGVVELPK 112 Query: 120 IAKDGKTIMVALMVNGGEEAVKQLPDQVDKLLSGVSADHYLTSEGLITEDTIVSSEAGLK 179 + V G + ++ D + K + I + + Sbjct: 113 DQAVLIEPFDTVTVQGFYRSQPEVNDAITKAAKA-KGAYSFYIVRQIDANQGGNQRITAF 171 Query: 180 KSEYITXXXXXXXXXXXXRSFVAPFVPLLTVGLSYIVSQSIVAFLVDRFDFPLSTFTQIF 239 + A L G + + + F + Sbjct: 172 IYKKDAKKRIVQSPDVIPADSEAGRAALAAGGEAAKKVEIPGVATTASPSSEVGRFFETQ 231 Query: 240 MVAVMFGIGTDYCILLISRFKEELATAEDTRSAIISTYRKAGGTVFYSGLAVFVGFLAIG 299 T + + A +I + T +A Sbjct: 232 SSKGGRYTVTLPDGTKVEELNKATAAMMVPFDSIKFSGNYGNMTEVSYQVAKRAAKKGAK 291 Query: 300 LSKFMLYRSAVAVAVGIAVMLLALVTVVPFFMAVLGKKLFWPSSSKLEHSESGIWGAAGS 359 Sbjct: 292 351 Query: 360 FSLKRPWXXXXXXXXXXXXXXXTYSGKLSFNSMDEIGPGYASVKGFNIISDSFGPGESMP 419 Sbjct: 352 411 Query: 420 GKIVIKNDDRMDTSEYMGLAEKISRELEKVDGVKAVRSMSRPTGEQINDFLIPTQVAALT 479 Sbjct: 412 471 Query: 480 DGLSQSNEGLTKIQSGL---EEASKQLKGN 506 Sbjct: 472 501 Score = 238 bits (607), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 0/299 (0%), Positives = 0/299 (0%) Query: 740 TGQIGKLTDGLSDSADGLKQITGGLNSAQDYLKQIQDAKDDELSGFLVPEEALKEGGIQQ 799 Sbjct: 580 639 Query: 800 VFDNYLSSDRKVMTLDVVYAANPYSAKAIDSMGDIQAAVDRAVKGTKLENAETAISGVSS 859 Sbjct: 640 699 Query: 860 TYSDLQKISNEDYTRTXXXXXXXXXXXXXXXXRSIIMPLYLIVSLLITYFTALGVTEAIF 919 Sbjct: 700 759 Query: 920 VHVLDYSGITWTTPFFSFVMLIALGVDYSIFLMDRFNENKTWDVREAILHAMRNMGTVIL 979 Sbjct: 760 819 Query: 980 SAVVILGGTFASMYPSGVLSMMQIATVVLSGXXXXXXXXXXXXXXXXXXXXGRANWWPF 1038 Sbjct: 820 878 >MT1220 [R] COG2409 Predicted drug exporters of the RND superfamily Length = 1002 Score = 118 bits (295), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 118/536 (22%), Positives = 228/536 (42%), Gaps = 26/536 (4%) Query: 11 IIAVWLSAAVVLFMTAPGMSDLVREKGQISVPDGYTSTRAAEIMKEVADAKGGETLHQVA 70 ++ W++ A+VL M P ++++ + +P S+ A M E G E + V Sbjct: 1 MVGCWVALALVLPMAVPSLAEMAQRHPVAVLPADAPSSVAVRQMAEAFHESGSENILVVL 60 Query: 71 LVFNKPDGLAAEDTESIKQGVEKLAAEKEALKIDSITDPFSQAELKDTLIAKDGKTIMVA 130 L K GL A D V++L +A + + D + L++ L +KDGK ++ Sbjct: 61 LTDEK--GLGAADENVYHTLVDRL--RNDAKDVVMLQDFLTTPPLREVLGSKDGKAWILP 116 Query: 131 LMVNG--GEEAVKQLPDQVDKLLSGVSADHYLTSEGLITEDTIVS-SEAGLKKS---EYI 184 + + G G V++++ A LT+ T+ ++AG + E Sbjct: 117 IGLAGDLGTPKSYHAYTDVERIVKRTVAGTTLTANVTGPAATVADLTDAGARDRASIELA 176 Query: 185 TXXXXXXXXXXXXRSFVAPFVPLLTVGLSYIVSQSIVAFLVDRFDFPLSTFTQIFMVAVM 244 R+ V +PL+T+G S + +Q++VA + +S + + A++ Sbjct: 177 IAVMLLVILMVIYRNPVTMLLPLVTIGASLMTAQALVAGVSLVGGLAVSNQAIVLLSAMI 236 Query: 245 FGIGTDYCILLISRFKEELATAEDTRSAIISTYRKAGGTVFYSGLAVFVGFLAIGLSKFM 304 G GTDY + LISR+ E + E A+ G + S V + FL + +K Sbjct: 237 AGAGTDYAVFLISRYHEYVRLGEHPERAVQRAMMSVGKVIAASAATVGITFLGMRFAKLG 296 Query: 305 LYRS-AVAVAVGIAVMLLALVTVVPFFMAVLGKKLFW--PSSSKLEHSESGIWGAAGSFS 361 ++ + A+A+GIAV LA VT++P + VL W P ++ + W AG+ Sbjct: 297 VFSTVGPALAIGIAVSFLAAVTLLPAIL-VLASPRGWVAPRGERM----ATFWRRAGTRI 351 Query: 362 LKRPWXXXXXXXXXXXXXXXTYS-GKLSFNSMDEIGPGYASVKGFNIISDSFGPGESMPG 420 ++RP S +++ ++ P S G+ + F +++P Sbjct: 352 VRRPKAYLGASLIGLVALASCASLAHFNYDDRKQLPPSDPSSVGYAAMEHHFSVNQTIPE 411 Query: 421 KIVIKNDDRMDTSEYMGLAEKISRELEKVDGVKAVRSMSRPTGEQINDFLIPTQVAALTD 480 ++I + + T + E++++ + ++ GV VR ++RP GE + Q + + Sbjct: 412 YLIIHSAHDLRTPRGLADLEQLAQRVSQIPGVAMVRGVTRPNGETLEQARATYQAGQVGN 471 Query: 481 GLSQSNE-------GLTKIQSGLEEASKQLKGNEPKLNEAVSGSAKLTEGTAELKK 529 L ++ L ++ SG + L +++ AV+G L + A ++ Sbjct: 472 RLGGASRMIDERTGDLNRLASGANLLADNLGDVRGQVSRAVAGVRSLVDALAYIQN 527 Score = 117 bits (293), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 75/294 (25%), Positives = 133/294 (45%), Gaps = 2/294 (0%) Query: 745 KLTDGLSDSADGLKQITGGLNSAQDYLKQI-QDAKDDELSGFLVPEEALKEGGIQQVFDN 803 ++ DG+ D K + GLN A +L + DA ++GF VP + LK ++V Sbjct: 675 QVADGVQMLVDQTKNMGIGLNQASAFLMAMGNDASQPSMAGFNVPPQVLKSEEFKKVAQA 734 Query: 804 YLSSDRKVMTLDVVYAANPYSAKAIDSMGDIQAAVDRAVKGTKLENAETAISGVSSTYSD 863 ++S D + + NP+S A+D + I A T L +A ++SG D Sbjct: 735 FISPDGHTVRYFIQTDLNPFSTAAMDQVNTIIDTAKGAQPNTSLADASISMSGYPVMLRD 794 Query: 864 LQKISNEDYTRTXXXXXXXXXXXXXXXXRSIIMPLYLIVSLLITYFTALGVTEAIFVHVL 923 ++ D R+I+ PLYL+ S++I+Y +A+G+ +F V Sbjct: 795 IRDYYERDMRLIVAVTVVVVILILMALLRAIVAPLYLVGSVVISYMSAIGLGVVVF-QVF 853 Query: 924 DYSGITWTTPFFSFVMLIALGVDYSIFLMDRFNENKTWDVREAILHAMRNMGTVILSAVV 983 + W+ P +FV+L+A+G DY++ L R + VR +++ +R G VI +A + Sbjct: 854 LGQELHWSVPGLAFVVLVAVGADYNMLLASRLRDESALGVRSSVIRTVRCTGGVITAAGL 913 Query: 984 ILGGTFASMYPSGVLSMMQIATVVLSGXXXXXXXXXXXXXXXXXXXXGRANWWP 1037 I + + + S + +++Q ++ G GRA+WWP Sbjct: 914 IFAASMSGLLFSSIGTVVQGGFIIGVGILIDTFVVRTITVPAMATLLGRASWWP 967 >ML1231 [R] COG2409 Predicted drug exporters of the RND superfamily Length = 983 Score = 118 bits (295), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 73/294 (24%), Positives = 137/294 (46%), Gaps = 2/294 (0%) Query: 745 KLTDGLSDSADGLKQITGGLNSAQDYLKQI-QDAKDDELSGFLVPEEALKEGGIQQVFDN 803 ++ DG++ D + + L A +L ++ QDA ++GF VP + L +++ Sbjct: 683 RIADGVAVLVDQTRTMGTSLARASAFLMEMGQDASQPSMAGFNVPPQLLNTEDFKKLVQA 742 Query: 804 YLSSDRKVMTLDVVYAANPYSAKAIDSMGDIQAAVDRAVKGTKLENAETAISGVSSTYSD 863 ++S D + + NP+S+ A+D + I A T L +A +SG + T D Sbjct: 743 FISPDGHSVRYFIQTDLNPFSSAAMDQVNTILNVATGAQPNTTLSDASIYLSGYTVTLRD 802 Query: 864 LQKISNEDYTRTXXXXXXXXXXXXXXXXRSIIMPLYLIVSLLITYFTALGVTEAIFVHVL 923 + + D RSI+ P+YL+ S++++Y +ALG+ +F VL Sbjct: 803 TRDYYDRDLQLIVIVTMIVVLLILMALLRSIVAPIYLVGSVIVSYLSALGLCVLVF-QVL 861 Query: 924 DYSGITWTTPFFSFVMLIALGVDYSIFLMDRFNENKTWDVREAILHAMRNMGTVILSAVV 983 + W+ P +FV+L+A+G DY++ L R + + +R +++ +R+ G VI +A + Sbjct: 862 LRQQLHWSVPGLAFVVLVAVGADYNMLLASRLRDESSHGLRASVIRTVRSTGGVITAAGL 921 Query: 984 ILGGTFASMYPSGVLSMMQIATVVLSGXXXXXXXXXXXXXXXXXXXXGRANWWP 1037 I + + S + +++Q V+ SG RA+WWP Sbjct: 922 IFAASMFGLLLSSIATVVQAGFVLGSGILLDTFIVRTITVPAVAALLRRASWWP 975 Score = 111 bits (277), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 113/541 (20%), Positives = 237/541 (43%), Gaps = 29/541 (5%) Query: 11 IIAVWLSAAVVLFMTAPGMSDLVREKGQISVPDGYTSTRAAEIMKEVADAKGGETLHQVA 70 +I W A++L MT P +++L + + +P S+ AA+ + + E + V Sbjct: 2 VIGCWTLLALMLPMTVPSLTELTQRHPVVILPVDAPSSVAAKKISQAFHEVDSENVLIVL 61 Query: 71 LVFNKPDGLAAEDTESIKQGVEKLAAEKEALKIDSITDPFSQAELKDTLIAKDGKTIMVA 130 L +K GL D + V++L + + + + + D S L + L++KDGK ++ Sbjct: 62 LTDDK--GLGPADETVYRTLVDRLRNDTKDVVV--LQDFLSTPPLHELLVSKDGKAWILP 117 Query: 131 LMVNG--GEEAVKQ-------LPDQVDKLLSGVSADHYLTSEGLITEDTIVSSEAGLKKS 181 +++ G G A Q + Q + +G S LT D + Sbjct: 118 IVLAGELGTSASYQAYAGVAGIVKQTLESTAGSSLKANLTGPASTVADLTDAGARDRTSI 177 Query: 182 EYITXXXXXXXXXXXXRSFVAPFVPLLTVGLSYIVSQSIVAFLVDRFDFPLSTFTQIFMV 241 E + R+ + +PL+T+G S + +Q++V+ + +S + + Sbjct: 178 ELVIAVLLLTILMIIYRNPITMLLPLITIGASLMTAQAVVSGVSVLAGLAVSNQMIVLLS 237 Query: 242 AVMFGIGTDYCILLISRFKEEL----ATAEDTRSAIISTYRKAGGTVFYSGLAVFVGFLA 297 A++ G GTDY + LISR+ + + +A+D A+ G + S V + FL Sbjct: 238 AMIAGAGTDYAVFLISRYHDYIRMGSGSAQDAGCAVRQALISLGKVIAASAATVGITFLG 297 Query: 298 IGLSKFMLYRSA-VAVAVGIAVMLLALVTVVPFFMAVLGKKLFWPSSSKLEHSESGIWGA 356 + +K ++ + A+A+GIAV LA VT++P + + G + W + + W Sbjct: 298 MSFTKIRVFSTVGPALAIGIAVAFLAAVTLMPALLVLAGTR-GWVAPRR--DRAGAFWRR 354 Query: 357 AGSFSLKRPWXXXXXXXXXXXXXXXTYS-GKLSFNSMDEIGPGYASVKGFNIISDSFGPG 415 G ++RP S + +++ +I S G+ + F G Sbjct: 355 TGVRIVRRPVAYLSASMVILIVLALCASLVRFNYDDRKQIPASDESSVGYAALESHFPVG 414 Query: 416 ESMPGKIVIKNDDRMDTSEYMGLAEKISRELEKVDGVKAVRSMSRPTGEQINDF------ 469 +++P ++I++ + T + ++++ + ++ G+ VR ++RPTG+ + + Sbjct: 415 QAIPEYLLIQSPHDLRTPRALADMAELAQRVSQIPGIALVRGVTRPTGKPLEETSATYQA 474 Query: 470 -LIPTQVAALTDGLSQSNEGLTKIQSGLEEASKQLKGNEPKLNEAVSGSAKLTEGTAELK 528 ++ Q+ + + + +S L ++ SG + +L ++ +AV+G + L + A + Sbjct: 475 GMVGKQLGSASHLIGESTGDLNRLASGAGLLADKLGDVRIQVGQAVAGISGLLDNLAFAQ 534 Query: 529 K 529 K Sbjct: 535 K 535 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.316 0.133 0.368 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 61,418,076 Number of extensions: 2232482 Number of successful extensions: 7042 Number of sequences better than 1.0e-05: 27 Number of HSP's gapped: 7014 Number of HSP's successfully gapped: 51 Length of query: 1052 Length of database: 38,378,431 Length adjustment: 117 Effective length of query: 935 Effective length of database: 24,884,353 Effective search space: 23266870055 Effective search space used: 23266870055 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 121 (51.2 bits)