BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0504.0059.p (256 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin0490 [F] COG1051 ADP-ribose pyrophosphatase 147 2e-35 DR0192 [F] COG1051 ADP-ribose pyrophosphatase 103 3e-22 alr2484 [F] COG1051 ADP-ribose pyrophosphatase 85 1e-16 slr1690 [F] COG1051 ADP-ribose pyrophosphatase 75 9e-14 PA4916 [F] COG1051 ADP-ribose pyrophosphatase 68 2e-11 >lin0490 [F] COG1051 ADP-ribose pyrophosphatase Length = 346 Score = 147 bits (371), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 8/199 (4%), Positives = 27/199 (13%), Gaps = 16/199 (8%) Query: 3 ENEEQTYNVKKYRTPDGVPADIVMFTLTKRERKTVTKTLPLRELKVMLVKR-------KK 55 + E + T ++ + ++ V + Sbjct: 9 SSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQG--------INLIDVAEMYPVPPRPE 60 Query: 56 WPYAGMWALPGGFCQEDESIYDAATRELKEETGVDGGHLEYLGVYSKPGRDPRGWIISHA 115 + + ++ + + + + Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 116 FFALVEEWMLEHRQASDDAGEVGLFTXXXXXXXXXXXFDHHDIITDAYLRIQQQMLQTTI 175 + H L Y R + Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGY-SWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVS 179 Query: 176 ARQFLPHHFTLSELYQVIQ 194 L + Sbjct: 180 NETAFGVMRYLHLADKHDL 198 >DR0192 [F] COG1051 ADP-ribose pyrophosphatase Length = 346 Score = 103 bits (256), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 11/203 (5%), Positives = 23/203 (11%), Gaps = 20/203 (9%) Query: 45 ELKVMLVKRKKWPYAGMWALPGGFCQEDESIYDAATRELKEETGV--DGGHLEYLGVYSK 102 + G+ + + G E L + SK Sbjct: 28 SEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSREKLIIASK 87 Query: 103 PGRDPRGWIISHAFFALVEEWMLEHRQASDDAGEVGLFTXXXXXXXXXXXFDHHDIITDA 162 R ++ + Sbjct: 88 VSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTD----YLDLYQVHWPQRPTNCFGK 143 Query: 163 YLRIQQQMLQTTIARQFLPHHFTLSELYQVIQTVV-PEFKEPNFIRKITSTRSRQGILKE 221 L ++ V E + Sbjct: 144 LGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLHLAD----KHD-- 197 Query: 222 VRDEAGNPVSSNQYS-QRPAQLY 243 P + Sbjct: 198 ------LPRIVTIQNPYSLLNRS 214 >alr2484 [F] COG1051 ADP-ribose pyrophosphatase Length = 248 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 102/207 (49%), Gaps = 20/207 (9%) Query: 46 LKVMLVKRKKWPYAGMWALPGGFCQEDESIYDAATRELKEETGVDGGHLEYLGVYSKPGR 105 L V+LV R++ P+ W+LPG +E ES+ DAA R + E+ V +LE L + P R Sbjct: 39 LLVLLVMRQQEPFLNYWSLPGTLVREGESLEDAAYRIMAEKIRVKNLYLEQLYTFGGPNR 98 Query: 106 DPRGWI-------ISHAFFALVEEWMLEHRQASDDAGEVGLFTXXXXXXXXXXXFDHHDI 158 DPR +S ++FALV +A A V FDH++I Sbjct: 99 DPREATGSYGVRYLSVSYFALV-----RFEEAELIADGVTGIAWYPVKQVPKLSFDHNEI 153 Query: 159 ITDAYLRIQQQMLQTTIARQFLPHHFTLSELYQVIQTVVPEFKEPNFIRKITSTRSRQGI 218 + + R++ ++ + +A + LP FTL++LYQ+ TV+ E NF ++ R+R Sbjct: 154 LAYGHRRLRNKLEYSPVAFEVLPEMFTLNDLYQLYTTVLGE----NF-SDYSNFRARLLK 208 Query: 219 LKEVRDEAGNPVSSNQYSQRPAQLYMF 245 L + D + ++ + RPA LY F Sbjct: 209 LGFLSDTG---IKVSRGAGRPASLYKF 232 >slr1690 [F] COG1051 ADP-ribose pyrophosphatase Length = 261 Score = 75.1 bits (183), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 58/202 (28%), Positives = 93/202 (46%), Gaps = 22/202 (10%) Query: 52 KRKKWPYAGMWALPGGFCQEDESIYDAATRELKEETGVDGGHLEYLGVYSKPGRDPRGW- 110 KR+ PY W+ PG + E++ AA R L E+ V +LE L + PGRDPR Sbjct: 58 KREDQPYQNYWSFPGTLVRMGETLEGAAHRILSEKIAVKNLYLEQLYTFGNPGRDPREAP 117 Query: 111 ------IISHAFFALVEEWMLEHRQASDDAGEVGLFTXXXXXXXXXXXFDHHDIITDAYL 164 +S ++FAL+ + A + + + FDH+ I+ Y Sbjct: 118 DQYGVRYLSVSYFALI-----RYEDAQLMSKNLSQVSWHNVAAIPTLAFDHNQILDYGYQ 172 Query: 165 RIQQQMLQTTIARQFLPHHFTLSELYQVIQTVVPE-FKEPNFIRKITSTRSRQGILKEVR 223 R++ ++ + IA + LP FTL++L+Q+ TV+ E F + + R S + G LK+ Sbjct: 173 RLRNKLEYSPIAFEVLPELFTLNDLFQLYTTVLGEDFADYSNFR---SRLLKLGFLKDTG 229 Query: 224 DEAGNPVSSNQYSQRPAQLYMF 245 + V RPA L+ F Sbjct: 230 QKISKGVG------RPASLFRF 245 >PA4916 [F] COG1051 ADP-ribose pyrophosphatase Length = 346 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 12/211 (5%), Positives = 32/211 (15%), Gaps = 12/211 (5%) Query: 42 PLRELKVMLVKRKKWPYAGMWALPGGFCQ---EDESIYDAATRELKEETGVDGGHLEYLG 98 + G E + + ET V ++ Sbjct: 19 GTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGS 78 Query: 99 VYSKPGRDPRGWIISHAFFALVEEWMLEHRQASDDAGEVGLFTXXXXXXXXXXXFDHHDI 158 + + + + + + Sbjct: 79 REKLIIASKVSGPSRNNDKGIRPD---QALDRKNIREALHD--SLKRLQTDYLDLYQVHW 133 Query: 159 ITDAYLRIQQQMLQTTIARQFLPHHFTLSELYQVIQTVVPEFKEPNFIRKITSTRSRQGI 218 + T + + TL L + + + + R Sbjct: 134 PQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLHLA 193 Query: 219 LKEV----RDEAGNPVSSNQYSQRPAQLYMF 245 K N+ + Sbjct: 194 DKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQ 224 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.319 0.135 0.405 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 18,694,647 Number of extensions: 770799 Number of successful extensions: 1192 Number of sequences better than 1.0e-05: 18 Number of HSP's gapped: 1183 Number of HSP's successfully gapped: 18 Length of query: 256 Length of database: 38,378,431 Length adjustment: 104 Effective length of query: 152 Effective length of database: 26,383,695 Effective search space: 4010321640 Effective search space used: 4010321640 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 114 (48.5 bits)