BLASTP 2.2.18 [Mar-02-2008]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0492.0003.p
         (604 letters)

Database: COG 
           115,334 sequences; 38,378,431 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

MK1297 [R] COG1353 Predicted hydrolase of the HD superfamily (pe...    77   1e-13
TM1794 [R] COG1353 Predicted hydrolase of the HD superfamily (pe...    71   4e-12

>MK1297 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted
           catalytic motifs)
          Length = 793

 Score = 76.6 bits (187), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 54/161 (33%), Positives = 80/161 (49%), Gaps = 18/161 (11%)

Query: 312 LEELYGKILKEPTPYYALVVGDGDRMGDALRKMKTPAEHQSFTEHLSGFASEVERIVFKD 371
           LE LY       TPYYAL+  DGDRMG+     + P   +  +     F  +  RIV   
Sbjct: 535 LENLY-------TPYYALLKLDGDRMGELF--SRDPETTRGASRATIEFGLKAMRIVHGH 585

Query: 372 DIKGQMIYSGGDDLMALLPVHRCLAAAQEIRQAFTNTMTLALPDEDQRPTLSVGIAIVHM 431
              G ++Y GGDD+ A LP+H  L  A E+ + F  ++      +  + T S G+A+VH 
Sbjct: 586 --YGVLLYCGGDDVFAALPLHTALDCAFELEETFRESL------KKWKGTCSAGLAVVHH 637

Query: 432 FEPLEDSLLIARAAEALAK-VRRDELAIHFQKRSGSEEMRV 471
             PL D++ +A   E  AK   R+ LA+   +R+  E + V
Sbjct: 638 LHPLRDAIDLAYRLEKRAKEAGRNRLAVGLYRRNAPERVAV 678


>TM1794 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted
           catalytic motifs)
          Length = 815

 Score = 71.2 bits (173), Expect = 4e-12,   Method: Compositional matrix adjust.
 Identities = 62/203 (30%), Positives = 87/203 (42%), Gaps = 65/203 (32%)

Query: 326 YYALVVGDGDRMGD---------------------------------ALRKMKT--PAEH 350
           Y A+++ DGDRMGD                                  L++ KT  PA H
Sbjct: 496 YIAVLLMDGDRMGDWMLGENAPFLEKVINPKVIEMFQETDDLKYAWEKLKEFKTIQPAYH 555

Query: 351 QSFTEHLSGFASEVERIVFKDDIKGQMIYSGGDDLMALLPVHRCLAAAQEIRQAFTNTMT 410
           +  +  L  F+  V +IV  D   G ++YSGGDD++ALLP    L  A +IR+ F+  + 
Sbjct: 556 RGVSRTLGIFSQLVGKIV--DRHNGMLVYSGGDDVLALLPADSVLECANDIRKFFSGHLE 613

Query: 411 LALPDE-----------------DQRP---------TLSVGIAIVHMFEPLEDSLLIARA 444
             +  E                 + +P         T+S GIAIVH   PL+ +L IAR 
Sbjct: 614 YEIEIESGSDVERFRSENGVLYHNDKPFAPLMGRAATMSAGIAIVHHKFPLQVALKIARE 673

Query: 445 AEALAK--VRRDELAIHFQKRSG 465
           AE  AK    R+   +   KRSG
Sbjct: 674 AEKRAKNVYGRNAFCVTQVKRSG 696



 Score = 57.0 bits (136), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 39/122 (31%), Positives = 63/122 (51%), Gaps = 20/122 (16%)

Query: 3   ISIGPVQEFIAQARKTRDLWFGSHLLSEISKEAARRLAEAHN-ARMIFPYIHK------- 54
           ++IGPVQE IAQARK +DLW GS+LLS +   A   + + +    +I PY+         
Sbjct: 195 VAIGPVQEVIAQARKVKDLWAGSYLLSYLIYGAIEVVGKKYGFDSIISPYLRGNYFVKET 254

Query: 55  -EKIAYGLDDL----------KVANKVLAIVPTNDPKAVALDVRRAVVTKWLGYANKAKE 103
            E +   L+DL           + N  +AIVP++D + +  +   A+  +W    ++ KE
Sbjct: 255 LESMGVDLEDLCPVPPRREVASLPNLFVAIVPSSD-EEILKECEEAIRNRWKTIVDETKE 313

Query: 104 EL 105
           +L
Sbjct: 314 KL 315


  Database: COG
    Posted date:  Aug 3, 2010  9:58 AM
  Number of letters in database: 38,378,431
  Number of sequences in database:  115,334
  
Lambda     K      H
   0.317    0.133    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 115334
Number of Hits to DB: 41,167,742
Number of extensions: 1640582
Number of successful extensions: 3445
Number of sequences better than 1.0e-05: 2
Number of HSP's gapped: 3445
Number of HSP's successfully gapped: 3
Length of query: 604
Length of database: 38,378,431
Length adjustment: 112
Effective length of query: 492
Effective length of database: 25,461,023
Effective search space: 12526823316
Effective search space used: 12526823316
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 119 (50.4 bits)