BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0490.0046.p (386 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_yloI [H] COG0452 Phosphopantothenoylcysteine synthetase/decar... 392 e-109 BH2510 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarb... 388 e-108 Cgl1566 [H] COG0452 Phosphopantothenoylcysteine synthetase/decar... 230 2e-60 SPy1222 [H] COG0452 Phosphopantothenoylcysteine synthetase/decar... 122 1e-27 L166912 [H] COG0452 Phosphopantothenoylcysteine synthetase/decar... 119 8e-27 >BS_yloI [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase Length = 346 Score = 392 bits (1008), Expect = e-109, Method: Compositional matrix adjust. Identities = 0/375 (0%), Positives = 0/375 (0%), Gaps = 4/375 (1%) Query: 1 LTSKLTQKGATVHVIMTASAKQFITELTLQSLSKQRVYSDTFQERDPSSISHIDLADSAD 60 + ++ A + + + ++ R + E + + Sbjct: 23 FGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSREKL 82 Query: 61 LVLVAPATANIIAKMAHGLADDMLSTXXXXXXXXXXXXXXXNVHMYQHPAVMDNINTLYK 120 ++ + + + + + Sbjct: 83 IIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPTNCFG 142 Query: 121 RGVKFIEPGEGQLACGYVGKGRLEEPEEIVKVVEQFFALQGSAANGPLAGKKVVITAGGT 180 + ++ E + + Sbjct: 143 KLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFG---VMRYLHLADKHDLP 199 Query: 181 IERIDPVRYITNDSSGKMGFALSRAARAMGAEVTLIAARTDEAPPQDPEIDVVRVESAAD 240 Y + S ++G A + Sbjct: 200 RIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKYLNG-AKPAGARNTL 258 Query: 241 MYEAVLNAWQDCDILVKAAAVSDYRPRQSAESKIKKSGDTLSLELVKTTDILENLGKQKG 300 + + V A R + Sbjct: 259 FSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQPFVASTLLGATTMDQLKTN 318 Query: 301 KQFLIGFAAETGNAEFYARDKLIRKNLDLIVANDVTMEGAGFGTDTNIVSVYDAEGLVLD 360 Sbjct: 319 378 Query: 361 LPQTSKDEVARQLLQ 375 Sbjct: 379 393 >BH2510 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase Length = 346 Score = 388 bits (997), Expect = e-108, Method: Compositional matrix adjust. Identities = 0/377 (0%), Positives = 0/377 (0%), Gaps = 6/377 (1%) Query: 5 LTQKGATVHVIMTASAKQFITELTLQSLSKQRVYSDTFQERDPSSISHIDLADSADLVLV 64 ++ A + + + ++ R + E + + ++ Sbjct: 27 NSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSREKLIIAS 86 Query: 65 APATANIIAKMAHGLADDMLSTXXXXXXXXXXXXXXXNVHMYQHPAVMDNINTLYKRGVK 124 + + + + + + Sbjct: 87 KVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPTNCFGKLGY 146 Query: 125 FIEPGEGQLACGYVGKGRLEEPEEIVKVVEQFFALQGSAANGPLAGKKVVITAGGTIERI 184 ++ E + + + Sbjct: 147 SWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFG----VMRYLHLADKHDLPRIV 202 Query: 185 DPVRYITNDSSGKMGFALSRAARAMGAEVTLIAARTDEAPPQDPEIDVVRVESAADMYEA 244 + + + + + ++ + A + + Sbjct: 203 TIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKY--LNGAKPAGARNTLFS 260 Query: 245 VLNAWQDCDILVKAAAVSDYRPRQSAESKIKKSGDTLSLELVKTTDILENLGKQKGKQFL 304 + AA D R + V +T + Q Sbjct: 261 RFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQPFVASTLLGATTMDQLKTNIE 320 Query: 305 IGFAAETGNAEFYARDKLIRKNLDLIVANDVTMEGAGFGTDTNIVSVYDAEGLVLDLPQT 364 Sbjct: 321 380 Query: 365 SKDEVARQLLQLAAKRI 381 Sbjct: 381 397 >Cgl1566 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase Length = 346 Score = 230 bits (587), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 0/389 (0%), Positives = 0/389 (0%), Gaps = 23/389 (5%) Query: 5 LTQKGATVHVIMTASAKQFITELTLQSLSKQRVYSDTFQERDPSSISHIDLADSADLVLV 64 Q V + + + + ++ + + A V Sbjct: 33 HAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLA--KHGSREKLIIASKVSG 90 Query: 65 APATANIIAKMAHGLADDMLSTXXXXXXXXXXXXXXXNVHMYQHPAVMDNINTLYKRGVK 124 + + L + ++ + L Sbjct: 91 PSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTD 150 Query: 125 FIEPGEGQLACGYVGKGRLEEPEEIVKVVEQFFALQGSAANGPLAGKKVVITAGGTIERI 184 + + + + V + G LA K + Sbjct: 151 SAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAF--GVMRYLHLADKHDLPRIVTIQNPY 208 Query: 185 DPVRYITNDSSGKMGFALSRAARAMGAEVTLIAARTDEAP-PQDPEIDVVRVESAADMYE 243 + ++ A + S Y Sbjct: 209 SLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKYLNGAKPAGAR--NTLFSRFTRYS 266 Query: 244 AVLNAWQDCDILVKAAAVSDYRPRQSAESKIKKSGDT-----LSLELVKTTDILENLGKQ 298 + A + + ++ + T+I + Sbjct: 267 GEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQPFVASTLLGATTMDQLKTNIESLHLEL 326 Query: 299 K------GKQFLIGFAAETGN----AEFYARDKLIRKNLDLIVANDVTMEGAGFGTDTNI 348 Sbjct: 327 SEDVLAE- 385 Query: 349 VSVYDAEGLVLDLPQTSKDEVARQLLQLA 377 Sbjct: 386 414 >SPy1222 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase Length = 346 Score = 122 bits (305), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 11/161 (6%), Positives = 32/161 (19%), Gaps = 2/161 (1%) Query: 1 LTSKLTQKGATVHVIMTASAKQFITELTLQSLSKQRVYSDTFQERDPSSISHIDLADSAD 60 +T A H + + Q I + + + +T + + + S + Sbjct: 21 MTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSRE 80 Query: 61 LVLVAPATANIIAKMAHGLADDMLSTXXXXXXXXX--XXXXXXNVHMYQHPAVMDNINTL 118 +++A + G+ D + Sbjct: 81 KLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPTNC 140 Query: 119 YKRGVKFIEPGEGQLACGYVGKGRLEEPEEIVKVVEQFFAL 159 + + ++ E Sbjct: 141 FGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNE 181 >L166912 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase Length = 211 Score = 119 bits (298), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 13/152 (8%), Positives = 31/152 (20%), Gaps = 2/152 (1%) Query: 1 LTSKLTQKGATVHVIMTASAKQFITELTLQSLSKQRVYSDTFQERDPSSISHIDLADSAD 60 T++L +I + Q ++ +K ++T + + Sbjct: 20 PTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTI 79 Query: 61 LVLVAPATANIIAKMAHGLADDMLSTXXXXXXXXXXX--XXXXNVHMYQHPAVMDNINTL 118 + + A I + NV + Sbjct: 80 GLYNSKAENIIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDT 139 Query: 119 YKRGVKFIEPGEGQLACGYVGKGRLEEPEEIV 150 + V V + L+ Sbjct: 140 HIFRVCNRTQFAPGKNVEQVEEKLLKVVPAEF 171 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.315 0.131 0.358 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 25,348,140 Number of extensions: 1074566 Number of successful extensions: 3406 Number of sequences better than 1.0e-05: 12 Number of HSP's gapped: 3390 Number of HSP's successfully gapped: 12 Length of query: 386 Length of database: 38,378,431 Length adjustment: 108 Effective length of query: 278 Effective length of database: 25,922,359 Effective search space: 7206415802 Effective search space used: 7206415802 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 117 (49.7 bits)