BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0489.0023.p (2551 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_pksL_3 [Q] COG3321 Polyketide synthase modules and related pr... 506 e-142 all1649 [Q] COG3321 Polyketide synthase modules and related prot... 374 e-102 all1648_1 [Q] COG3321 Polyketide synthase modules and related pr... 371 e-101 BS_pksK_3 [Q] COG3321 Polyketide synthase modules and related pr... 366 e-100 all2646 [Q] COG3321 Polyketide synthase modules and related prot... 357 1e-97 >BS_pksL_3 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1206 Score = 506 bits (1302), Expect = e-142, Method: Compositional matrix adjust. Identities = 390/1264 (30%), Positives = 612/1264 (48%), Gaps = 145/1264 (11%) Query: 1304 AIIGYACKFPMAEDAEQFWRNLTTGVGAIRPFPESRRKDTDGYLAANQISPEGHAYCQG- 1362 AI+G + ++P A + ++W NL AIR P SR D D Y ++ +G YC+ Sbjct: 2 AIVGMSGRYPGARNVREYWDNLVHARNAIRDIPTSRW-DVDKYYDP-VLNKKGKVYCKSM 59 Query: 1363 GYLEEIDRFDSAFFHISPREGELMDPEQRLLLENVYQAAEHSGLGGTILSGTRTGVYVGK 1422 G L++I+ FD FF+I P E ELMDP+ R+ L+ Y+A E +G L+ + GVY+G Sbjct: 60 GMLDDIEHFDPLFFNIPPSEAELMDPQHRIFLQEGYKAFEDAGYNARTLNEKKCGVYLG- 118 Query: 1423 DTTGRNEYNNRVDILDPLKVTSGSTGILASRIAYYLNLNGPCLVVDTACSSSLTAICLAT 1482 NEY ++ T S I A+RI Y+LNL GP + +DTACSSSL LA Sbjct: 119 --IMSNEYGVMLNRQSRANATGNSFAIAAARIPYFLNLKGPAIPIDTACSSSLVGTHLAR 176 Query: 1483 QALKQGQIDIAIVAGVSLAYLPTQRNSLID----SADEMIRPFDAGANGTMWGEGAGTII 1538 QAL +ID+A+V GVSL P S+ + S D + FD GANG + GEGAG ++ Sbjct: 177 QALINKEIDMALVGGVSLYLTPESYMSMCEAGMLSPDGQCKAFDNGANGFVPGEGAGALV 236 Query: 1539 LKRMSEAVQDNHVIHAVIKGSEMNNNGTSNGITAPNAEAQEKVLVAAWKAANIDPETISY 1598 LKR+ +A D I+ +I GS +N +G +NGITAP+A++Q + ++ I PE+ISY Sbjct: 237 LKRLKDAEADRDHIYGIIIGSGINQDGKTNGITAPSAKSQMDLERDIYETYGIHPESISY 296 Query: 1599 IEAHATGTKLGDPIEVKGITNAFRRFTNKRQFCAAGTVKANIGHLVGASGMASVIKMIMA 1658 +E H TGTK GDPIE++ ++ F+ T+K+QFCA G+VK+NIGH A+G+A V K+++ Sbjct: 297 VEMHGTGTKQGDPIELEALSTVFQEKTDKKQFCAIGSVKSNIGHTSAAAGVAGVQKVLLC 356 Query: 1659 FKHKQLPPVLQFQNPNPFIEFADSPIYVNDRLQDW-SGSAAPRRCGISSFGFSGTNCHIL 1717 HK L P L F PN EF SP+YVN L+ W + PRR +SSFG+SGTN HI+ Sbjct: 357 MNHKTLVPTLNFTTPNEHFEFEHSPLYVNTELKPWETADGKPRRACVSSFGYSGTNAHIV 416 Query: 1718 LEE-PPVFTNPQEAKQDWHIL-ALSAKTAGSLSALIKRYFHMINGTVTLDLQNLCFTANI 1775 +EE P N + KQ L LSAK L A + + +DL+++ +T Sbjct: 417 IEEYQPEKRNDRLTKQHRSALFVLSAKKEKQLKAYAEAMKDFVTSNEDIDLEDMAYTLQT 476 Query: 1776 SRGHYEHRIVLLFRT-ENELRAKFKYLQE---AGILQAADRDQRIYYKASRISYDQEGFD 1831 R ++R+ L + E ++A YL E A I A + ++ K +D Sbjct: 477 GREAMDYRMAFLADSREMLIKALDDYLAEMPNASIFAAHVKTKKSEIKLFETDHD----- 531 Query: 1832 GDGLLEQDKLKLNKLAESLIEEWSVEETLSAVDNLHKIARLYTDGADINWDRLYQGKQHR 1891 A++L++ W +E+ L K+A L+ G I+W++LY R Sbjct: 532 ---------------AKALLQTW-IEKK-----RLEKVAELWVKGLQIDWNKLYGEYTPR 570 Query: 1892 LTELPAYAYEPVRHWIGGSARKGSSSPGKYYQLQWLPDH-----REQPAGIKPDEG---- 1942 LPAY + +W+ + + Q + +P + QP I+P E Sbjct: 571 RISLPAYPFAEEYYWLPTQEGEPETIATAMPQFELMPKRCFLRKQWQPCPIEPAEMTNQT 630 Query: 1943 -AWLFVGGTGTKSQEL------LRVLRKQEIELIEVTPGARYHQLAANRYSIGSG--EEY 1993 A L T ++EL R+ QE++ + A Y +A IG G E+ Sbjct: 631 VAILANEETMALAEELSAYFSTYRIFDSQELDRVS---AADYEHVAGAIDLIGCGTSHEH 687 Query: 1994 SL----LLKEL--SNRGIKHVIHCLSLADEKIAGIEDLHAAENRGVYNLHHLVTALLNGQ 2047 S+ L++L R KH + L + + L A N GV LL+G Sbjct: 688 SMGWINWLQKLIEQGRASKHHLTVLGVT-------KGLEAYANEGV---------LLSGA 731 Query: 2048 YHQELNLFFVADHTFLVNRHEPV-LNPHHAVLFGMAKVIPQEYPQFKCRCIDIDSATAPA 2106 L ++++ L +RH + H L A++I EY Sbjct: 732 SRAGLYRMLQSEYSHLTSRHADMECEASHEEL---ARLIAVEY----------------- 771 Query: 2107 TVWKEICSGKGDFQVAYRDNTRYLEHFGERRLEAAEA-GGVSLKENGVYVVTGGLGGIGL 2165 + + +V YR+ RY + E+ EAA + VS + V ++TGG G+GL Sbjct: 772 ------YAKSTESEVCYRNGQRYRAYLTEQPAEAALSHKQVSFSTDKVLLITGGTRGLGL 825 Query: 2166 AVAQYLSGKQRV-HLCLLNRRTLPPG--------PSQSQRIR---QIEANGSDVDLYSVD 2213 A++ V L L+ R LPP S +++I+ ++E G+ V + S+D Sbjct: 826 LCARHFVKTYGVKRLVLIGREELPPRDQWNSVKISSLAEKIKAVQELEDMGAQVQVLSLD 885 Query: 2214 ISAPNELQGVLQAIRTKYGQINGLFHCAGIAGE--GLLINKGKPEIKRVLDAKVTGTWLL 2271 ++ ++ L+ I G I G+ HCAG+ + I K EI +VL+ KV G L Sbjct: 886 LTDRVAVEQSLKTIHETMGAIGGVIHCAGMVNKQNPAFIRKSLEEIGQVLEPKVEGLQTL 945 Query: 2272 DQYTAQDHLDYFVLFSSVTSLLGGM--GQADYTAANAYLDGFSDYRQANNRRSVTINWPA 2329 + L +F LFSSV++ + + GQADY ANA++D F++ Q + V+I WP Sbjct: 946 FDLLQDEPLAFFTLFSSVSAAIPALAAGQADYAMANAFMDYFAEAHQ-DKCPIVSIQWPN 1004 Query: 2330 WKEVGMTLKYDIQEGRSPFLGLTEEQGISILDAVLQRKLSRIIAGEINERYFQNGDPSLP 2389 WKE G+ ++ + LT ++G+ +LD +L + ++ + + D + Sbjct: 1005 WKETGLGEVRSKALEQTGLISLTNDEGLQLLDQILSDRQYAVVLPAVPDTNVWKPDKLMQ 1064 Query: 2390 FAVPPQMISRGTGAFNPQEKVIADEPILPILKGRYDHSYNSYEISLAAMWQKVLGVAEVN 2449 ++P + +S + + E + ++ + S E+ +AA + Sbjct: 1065 PSLPVEALSHPETKEQTSTRNLFPETVDWLV------TLFSDELKIAA--------EDFE 1110 Query: 2450 VHLPFQETGGNSILATSLVKEIDGVYPGCVNIATLFAYPSIAKMAEYLKQKQSENESLQE 2509 PFQE G +SI+ LV++++ G ++ + LF YP+I A +L K + LQ Sbjct: 1111 TDEPFQEYGIDSIILAQLVQQMNQQLNGDIDPSILFEYPTIESFAHWLISKYDISRVLQP 1170 Query: 2510 ADPK 2513 + P+ Sbjct: 1171 SVPE 1174 Score = 334 bits (857), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 221/621 (35%), Positives = 325/621 (52%), Gaps = 53/621 (8%) Query: 41 IAVVGISGRFPKADRVEQFWDNLCSGRDCLDTFPEDRLHDGQALAPERHLAGGS-LKQGG 99 IA+VG+SGR+P A V ++WDNL R+ + P R + P + G K G Sbjct: 1 IAIVGMSGRYPGARNVREYWDNLVHARNAIRDIPTSRWDVDKYYDPVLNKKGKVYCKSMG 60 Query: 100 YLDEISFFDAEMFRISPKEALSMEPYQRIMLEVAYDTLVNAGYETQDILGSKTGVFIGRD 159 LD+I FD F I P EA M+P RI L+ Y +AGY + + K GV++G Sbjct: 61 MLDDIEHFDPLFFNIPPSEAELMDPQHRIFLQEGYKAFEDAGYNARTLNEKKCGVYLG-- 118 Query: 160 HVTGIEY-----RNYAAPDIFRLTGGWPGILASRISYVYNLKGPSVVFDTSCSSGLVGLH 214 + EY R A TG I A+RI Y NLKGP++ DT+CSS LVG H Sbjct: 119 -IMSNEYGVMLNRQSRA----NATGNSFAIAAARIPYFLNLKGPAIPIDTACSSSLVGTH 173 Query: 215 FACESLRRNECDMAFVGGISGLFYFPP-----VKEDGSLDQVESAEEKIRAFDKAAEGTV 269 A ++L E DMA VGG+S Y P + E G L S + + +AFD A G V Sbjct: 174 LARQALINKEIDMALVGGVS--LYLTPESYMSMCEAGML----SPDGQCKAFDNGANGFV 227 Query: 270 WGEGCGGLLLKPLSKAVADKDVIYAVIKGSGINNNGLSKGITAPNGEAQEELLKKVWKQA 329 GEG G L+LK L A AD+D IY +I GSGIN +G + GITAP+ ++Q +L + +++ Sbjct: 228 PGEGAGALVLKRLKDAEADRDHIYGIIIGSGINQDGKTNGITAPSAKSQMDLERDIYETY 287 Query: 330 QINPETIRYIETHGTGTILGDTIELNSIINAFQAFTSKKQFCGVGSVKTNIGHLVGASGI 389 I+PE+I Y+E HGTGT GD IEL ++ FQ T KKQFC +GSVK+NIGH A+G+ Sbjct: 288 GIHPESISYVEMHGTGTKQGDPIELEALSTVFQEKTDKKQFCAIGSVKSNIGHTSAAAGV 347 Query: 390 VSLIKAVLMLKHGEIPASLHFQTPSPYINLADSALFINDQRSKLEKGN-HPVRIGINSFG 448 + K +L + H + +L+F TP+ + S L++N + E + P R ++SFG Sbjct: 348 AGVQKVLLCMNHKTLVPTLNFTTPNEHFEFEHSPLYVNTELKPWETADGKPRRACVSSFG 407 Query: 449 FSGTNCHVLLEE-PPVPVYDN-NAENNVFLLTLSARSSQKLVEAAQSLQRFLLTNRSVNL 506 +SGTN H+++EE P D ++ L LSA+ ++L A++++ F+ +N ++L Sbjct: 408 YSGTNAHIVIEEYQPEKRNDRLTKQHRSALFVLSAKKEKQLKAYAEAMKDFVTSNEDIDL 467 Query: 507 ADMCCTASQFRNHFANRLAITFSSYEDLLAKL-KIIRETKELSLWSSHPGISFQLHEVVA 565 DM T R R+A S E L+ L + E S++++H V Sbjct: 468 EDMAYTLQTGREAMDYRMAFLADSREMLIKALDDYLAEMPNASIFAAH----------VK 517 Query: 566 DTKSQIEAWEIREGEKIALDKTANEAIRELLQKKAGSEMLWEQAARFYIKGASMDWRPLY 625 KS+I+ +E D A ++ ++KK E+ A ++KG +DW LY Sbjct: 518 TKKSEIKLFET--------DHDAKALLQTWIEKKR-----LEKVAELWVKGLQIDWNKLY 564 Query: 626 P--GCRKLAMPGNVLERTKYW 644 R++++P YW Sbjct: 565 GEYTPRRISLPAYPFAEEYYW 585 Score = 95.5 bits (236), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 89/351 (25%), Positives = 159/351 (45%), Gaps = 29/351 (8%) Query: 919 KLIVLGRTAIPDRESWQSIIMDNEDKQLLKKINGILAIEALGFTLDYHCVDICDEAQLRR 978 +L+++GR +P R+ W S+ + + L +KI + +E +G + +D+ D + + Sbjct: 839 RLVLIGREELPPRDQWNSVKISS----LAEKIKAVQELEDMGAQVQVLSLDLTDRVAVEQ 894 Query: 979 TVEQIRQDHGSINGVFHCAG-VGVGDIEDFGMSGQEFEQRHAVKTYGSWLVYNLTQEFNT 1037 +++ I + G+I GV HCAG V + S +E Q K G +++L Q+ Sbjct: 895 SLKTIHETMGAIGGVIHCAGMVNKQNPAFIRKSLEEIGQVLEPKVEGLQTLFDLLQDEPL 954 Query: 1038 GFTLLFSSAVSITG--GRGSLAYTAGNAFVDGLAETIRLQGKNVMAINWSTWEAT--ASR 1093 F LFSS + G Y NAF+D AE + + +++I W W+ T Sbjct: 955 AFFTLFSSVSAAIPALAAGQADYAMANAFMDYFAEAHQDKCP-IVSIQWPNWKETGLGEV 1013 Query: 1094 LSLQADKHFFEFLSTHQALQALDLIIRRGMFRTIVGKLNVQNKLLELENLWPFRLAGEIK 1153 S ++ L+ + LQ LD I+ + ++ + N + + P + ++ Sbjct: 1014 RSKALEQTGLISLTNDEGLQLLDQILSDRQYAVVLPAVPDTNVWKPDKLMQP---SLPVE 1070 Query: 1154 QALFPKTRQEERPVRQTSVTVKEPEGYTATHRELAQVWADILGLTT--ISVFDSFHQLGG 1211 P+T++ QTS PE T L +++D L + + F + G Sbjct: 1071 ALSHPETKE------QTSTRNLFPE----TVDWLVTLFSDELKIAAEDFETDEPFQEYGI 1120 Query: 1212 DSIHAAHLHKQWNERHPGTLDVTDIYRYPTIHEMAGYL----DSQRISQPA 1258 DSI A L +Q N++ G +D + ++ YPTI A +L D R+ QP+ Sbjct: 1121 DSIILAQLVQQMNQQLNGDIDPSILFEYPTIESFAHWLISKYDISRVLQPS 1171 >all1649 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1570 Score = 374 bits (960), Expect = e-102, Method: Compositional matrix adjust. Identities = 208/521 (39%), Positives = 299/521 (57%), Gaps = 11/521 (2%) Query: 1304 AIIGYACKFPMAEDAEQFWRNLTTGVGAIRPFPESRRKDTDGYLAANQISPEGHAYCQGG 1363 AIIG C+FP A+ + FW+ L+ GV AI P + R + D + N +P GG Sbjct: 5 AIIGIGCRFPGADSPQAFWQLLSNGVDAITEIP-AERWNIDEFYDRNPETPGKMNARYGG 63 Query: 1364 YLEEIDRFDSAFFHISPREGELMDPEQRLLLENVYQAAEHSGLGGTILSGTRTGVYVGKD 1423 +L ++DRFD FF ISPRE LMDP+QRLLLE ++A E +G+ L+G++TGV+VG Sbjct: 64 FLSQVDRFDPHFFGISPREALLMDPQQRLLLEVAWEALEDAGIVREQLTGSKTGVFVGIS 123 Query: 1424 TTGRNEYNNRVDILDP--LKVTSGSTGILASRIAYYLNLNGPCLVVDTACSSSLTAICLA 1481 T + + D +P +T I A R++Y NL GP L VDTACSSSL A+ LA Sbjct: 124 TNDYSRIHPEFDS-NPQGYDLTGNCINIAAGRLSYLFNLRGPSLAVDTACSSSLVAVHLA 182 Query: 1482 TQALKQGQIDIAIVAGVSLAYLPTQRNSLID----SADEMIRPFDAGANGTMWGEGAGTI 1537 Q++ + +AI +GV+L P +L S D + FD ANG + EGAG I Sbjct: 183 CQSIWNQESSMAIASGVNLVLSPIGNIALSKLKALSPDGRCKTFDESANGYVRSEGAGCI 242 Query: 1538 ILKRMSEAVQDNHVIHAVIKGSEMNNNGTSNGITAPNAEAQEKVLVAAWKAANIDPETIS 1597 ILK +++A+ D+ I+AVI+GS +N++G S G+T P AQE ++ A + A + P+ IS Sbjct: 243 ILKPIAQALADHDPIYAVIRGSAINHDGRSKGLTVPYGPAQESLIRQALQQAQVQPKEIS 302 Query: 1598 YIEAHATGTKLGDPIEVKGITNAFRRFTNKRQFCAAGTVKANIGHLVGASGMASVIKMIM 1657 Y+E H TGT LGDPIE I + C G VK+NIGHL A+G+AS+IKM + Sbjct: 303 YVELHGTGTPLGDPIEAMAIGAVLGEGRDAAHPCLVGAVKSNIGHLEAAAGIASIIKMAL 362 Query: 1658 AFKHKQLPPVLQFQNPNPFIEFADSPIYVNDRLQDWSGSAAPRRCGISSFGFSGTNCHIL 1717 A K++Q+PP L F PNP+I F P+ V L W S + G+SSFGFSGTN H++ Sbjct: 363 ALKYQQIPPSLHFHQPNPYIPFDQLPLRVQTSLIPWPKSKYGAKAGVSSFGFSGTNAHVI 422 Query: 1718 LEEPPVFTNPQEAKQDW-HILALSAKTAGSLSALIKRYFHMINGTVTLD--LQNLCFTAN 1774 LE F +P++ + H+L LSA T ++ L Y +IN +QNLC++A+ Sbjct: 423 LEGVSSFNSPEQQTCKFPHLLPLSAHTPAAVQTLALGYQDLINAQKLTPEFVQNLCYSAS 482 Query: 1775 ISRGHYEHRIVLLFRTENELRAKFKYLQEAGILQAADRDQR 1815 + R H +R ++ + +L + + L A I + +R Sbjct: 483 VRRTHQSYRSAVVVNSPEDLPSCLQALATADITTQTKQSKR 523 Score = 350 bits (899), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 209/528 (39%), Positives = 298/528 (56%), Gaps = 29/528 (5%) Query: 39 EEIAVVGISGRFPKADRVEQFWDNLCSGRDCLDTFPEDR-----LHDGQALAPERHLAGG 93 E IA++GI RFP AD + FW L +G D + P +R +D P + A Sbjct: 2 EPIAIIGIGCRFPGADSPQAFWQLLSNGVDAITEIPAERWNIDEFYDRNPETPGKMNA-- 59 Query: 94 SLKQGGYLDEISFFDAEMFRISPKEALSMEPYQRIMLEVAYDTLVNAGYETQDILGSKTG 153 + GG+L ++ FD F ISP+EAL M+P QR++LEVA++ L +AG + + GSKTG Sbjct: 60 --RYGGFLSQVDRFDPHFFGISPREALLMDPQQRLLLEVAWEALEDAGIVREQLTGSKTG 117 Query: 154 VFIG--RDHVTGIEYRNYAAPDIFRLTGGWPGILASRISYVYNLKGPSVVFDTSCSSGLV 211 VF+G + + I + P + LTG I A R+SY++NL+GPS+ DT+CSS LV Sbjct: 118 VFVGISTNDYSRIHPEFDSNPQGYDLTGNCINIAAGRLSYLFNLRGPSLAVDTACSSSLV 177 Query: 212 GLHFACESLRRNECDMAFVGGISGLFYFPPVKEDGSLDQVESAEEKIRAFDKAAEGTVWG 271 +H AC+S+ E MA G++ L P S + S + + + FD++A G V Sbjct: 178 AVHLACQSIWNQESSMAIASGVN-LVLSPIGNIALSKLKALSPDGRCKTFDESANGYVRS 236 Query: 272 EGCGGLLLKPLSKAVADKDVIYAVIKGSGINNNGLSKGITAPNGEAQEELLKKVWKQAQI 331 EG G ++LKP+++A+AD D IYAVI+GS IN++G SKG+T P G AQE L+++ +QAQ+ Sbjct: 237 EGAGCIILKPIAQALADHDPIYAVIRGSAINHDGRSKGLTVPYGPAQESLIRQALQQAQV 296 Query: 332 NPETIRYIETHGTGTILGDTIELNSIINAFQAFTSKKQFCGVGSVKTNIGHLVGASGIVS 391 P+ I Y+E HGTGT LGD IE +I C VG+VK+NIGHL A+GI S Sbjct: 297 QPKEISYVELHGTGTPLGDPIEAMAIGAVLGEGRDAAHPCLVGAVKSNIGHLEAAAGIAS 356 Query: 392 LIKAVLMLKHGEIPASLHFQTPSPYINLADSALFINDQRSKLEKGNHPVRIGINSFGFSG 451 +IK L LK+ +IP SLHF P+PYI L + K + + G++SFGFSG Sbjct: 357 IIKMALALKYQQIPPSLHFHQPNPYIPFDQLPLRVQTSLIPWPKSKYGAKAGVSSFGFSG 416 Query: 452 TNCHVLLEEPPVPVYDNNAENNV---FLLTLSARSSQKLVEAAQSLQRFL----LTNRSV 504 TN HV+LE V +++ + LL LSA + + A Q + LT V Sbjct: 417 TNAHVILEG--VSSFNSPEQQTCKFPHLLPLSAHTPAAVQTLALGYQDLINAQKLTPEFV 474 Query: 505 NLADMCCTASQFRNHFANRLAITFSSYEDL------LAKLKIIRETKE 546 ++C +AS R H + R A+ +S EDL LA I +TK+ Sbjct: 475 Q--NLCYSASVRRTHQSYRSAVVVNSPEDLPSCLQALATADITTQTKQ 520 Score = 146 bits (369), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 129/443 (29%), Positives = 205/443 (46%), Gaps = 16/443 (3%) Query: 1944 WLFVGGTGTKSQELLRVLRKQEIELIEVTPGARYHQLAANRYSIG--SGEEYSLLLKELS 2001 WL QEL V+ I V+ G Y +L+++ Y I ++ LL ++S Sbjct: 968 WLIFSDNQGLGQELAAVVND---SCILVSSGESYEKLSSSHYQINPHQAADFQQLLADIS 1024 Query: 2002 NRGIKHVIHCLSLADEKIAGIEDLHAAENRGVYNLHHLVTALLNGQYHQELNLFFVADHT 2061 I V++ SL D I +L ++ + +L +LV AL L+ Sbjct: 1025 EP-ITKVVYLWSL-DSSI----NLENSQPQCYSHLLYLVQALAKISSKIAPQLWIGTQQA 1078 Query: 2062 FLVNRHEPVLNPHHAVLFGMAKVIPQEYPQFKCRCIDIDSATAPAT-VWKEICSGKGDFQ 2120 V +N L+GM +VI EYPQ ID + AT + E+ + G+ + Sbjct: 1079 QAVTPSCHQINVAQTPLWGMGQVIALEYPQLWGGLIDFGNQDVAATAIIAEMTAKTGEDR 1138 Query: 2121 VAYRDNTRYLEHFGERRLEAAEAGGVSLKENGVYVVTGGLGGIGLAVAQYLSGKQRVHLC 2180 VA+RD RY+ + A L +G Y++TGGLG +GL +A++L + HL Sbjct: 1139 VAFRDGKRYVARL--MPISAPLPAPQPLISDGSYLITGGLGALGLTLAEWLVQQGARHLV 1196 Query: 2181 LLNRR-TLPPGPSQSQRIRQIEANGSDVDLYSVDISAPNELQGVLQAIRTKYGQINGLFH 2239 L +R+ L + Q+IR +E G+ V + + D+S ++ + I+ ++ G+ H Sbjct: 1197 LTSRQGLLNQSEEKQQKIRALENQGATVKVVAADVSDYQQMSQLFAQIQLNSPKLRGIIH 1256 Query: 2240 CAGIAGEGLLINKGKPEIKRVLDAKVTGTWLLDQYTAQDHLDYFVLFSSVTSLLGGMGQA 2299 AG+ + + +V KVTG W L Q T LD+FV FSS+++LLG GQ Sbjct: 1257 AAGVLNDCSIAQMDSETFTKVFQPKVTGAWNLHQLTQDLSLDFFVCFSSMSALLGSRGQL 1316 Query: 2300 DYTAANAYLDGFSDYRQANNRRSVTINWPAWKEVGM-TLKYDIQEGRSPFLGLTEEQGIS 2358 Y AAN++LDG +RQ+ ++INW W E GM T Y++ R L + Sbjct: 1317 HYAAANSFLDGLVYHRQSLGLPGLSINWGPWAEGGMATQGYEVGLKRMGIEPLEPTAALQ 1376 Query: 2359 ILDAVLQRKLSRIIAGEINERYF 2381 +L +L + + IN F Sbjct: 1377 VLGGLLGSASMQTMVAAINWSAF 1399 Score = 120 bits (302), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 136/594 (22%), Positives = 242/594 (40%), Gaps = 46/594 (7%) Query: 706 CILVEIGRPYRKINAEHYHVS-NSVEDFSALCGELDISALEQILYAAPSREGLPDSLKEF 764 CILV G Y K+++ HY ++ + DF L ++ + +++Y DS Sbjct: 989 CILVSSGESYEKLSSSHYQINPHQAADFQQLLADIS-EPITKVVYLWSL-----DSSINL 1042 Query: 765 KESFNQTVMNLLYLVKAL-QAANTMNKDLDIALITRNAHVLQPMDTGSDPFAHTLYGIGK 823 + S Q +LLYLV+AL + ++ + L I T+ A + P + L+G+G+ Sbjct: 1043 ENSQPQCYSHLLYLVQALAKISSKIAPQLWIG--TQQAQAVTPSCHQINVAQTPLWGMGQ 1100 Query: 824 SILQENRSFHVRHIDISNEPADLEALPAELEVPSAQYSVALRHGRRYVEVIKRXXXXXXX 883 I E ID N+ A+ AE+ + + VA R G+RYV + Sbjct: 1101 VIALEYPQLWGGLIDFGNQDVAATAIIAEMTAKTGEDRVAFRDGKRYVA--RLMPISAPL 1158 Query: 884 XXXXXXXXXXTFXXXXXXXXXXXEVCKYLSQKNRVKLIVLGRTAIPDRESWQSIIMDNED 943 ++ + ++L Q+ L++ R Q ++ +E+ Sbjct: 1159 PAPQPLISDGSYLITGGLGALGLTLAEWLVQQGARHLVLTSR---------QGLLNQSEE 1209 Query: 944 KQLLKKINGILAIEALGFTLDYHCVDICDEAQLRRTVEQIRQDHGSINGVFHCAGVGVGD 1003 KQ I A+E G T+ D+ D Q+ + QI+ + + G+ H AGV + D Sbjct: 1210 KQ-----QKIRALENQGATVKVVAADVSDYQQMSQLFAQIQLNSPKLRGIIHAAGV-LND 1263 Query: 1004 IEDFGMSGQEFEQRHAVKTYGSWLVYNLTQEFNTGFTLLFSSAVSITGGRGSLAYTAGNA 1063 M + F + K G+W ++ LTQ+ + F + FSS ++ G RG L Y A N+ Sbjct: 1264 CSIAQMDSETFTKVFQPKVTGAWNLHQLTQDLSLDFFVCFSSMSALLGSRGQLHYAAANS 1323 Query: 1064 FVDGLAETIRLQGKNVMAINWSTWE---ATASRLSLQADKHFFEFLSTHQALQALDLIIR 1120 F+DGL + G ++INW W + + E L ALQ L ++ Sbjct: 1324 FLDGLVYHRQSLGLPGLSINWGPWAEGGMATQGYEVGLKRMGIEPLEPTAALQVLGGLLG 1383 Query: 1121 RGMFRTIVGKLNVQ--NKLLELENLWPFRLAGEIKQALFPKTRQEERPVRQTSVTVKEPE 1178 +T+V +N K++ + F A +++ + R + + P Sbjct: 1384 SASMQTMVAAINWSAFGKIVAAKGRVAFLEALLTQESKDGSNGENFRQKLSAAPLHRRPA 1443 Query: 1179 GYTA-THRELAQVWADILGLTTISVFDSFHQLGGDSIHAAHLHKQWNERHPGTLDVTDIY 1237 T +E+AQV G V F +G DS+ + +L T ++ Sbjct: 1444 LLTTQVQQEVAQVLGHS-GSYVPEVEQGFFDMGMDSLMSVQFRHSLEALLAVSLPSTLVF 1502 Query: 1238 RYPTIHEMAGYL------------DSQRISQPAALNLDSILEGFKGSKYSKEEA 1279 P+I ++ YL DS + A++ +++ + +G ++ EA Sbjct: 1503 ECPSIGDVVSYLMREVFAWQLDADDSSAMESQASVVIENTIAQLEGLSTAETEA 1556 >all1648_1 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1041 Score = 371 bits (952), Expect = e-101, Method: Compositional matrix adjust. Identities = 205/528 (38%), Positives = 305/528 (57%), Gaps = 18/528 (3%) Query: 1280 KRLLAEWTEHSSVERLQPAESDEYAIIGYACKFPM-AEDAEQFWRNLTTGVGAIRPFPES 1338 K ++A + +E L+ +++ AI+G C+FP A + E+FW L G I P Sbjct: 11 KAIIALKEARTKIESLERTQNEPIAIVGMGCRFPGDANNPEKFWELLRQGKDGITTVP-P 69 Query: 1339 RRKDTDGYLAANQISPEGHAYCQGGYLEEIDRFDSAFFHISPREGELMDPEQRLLLENVY 1398 +R D D Y + P GG++ +D+FD FF I+PRE +DP+QRLLLE + Sbjct: 70 QRWDIDAYYDDDPDVPNKMYARYGGFINNVDQFDPQFFGITPREAIALDPQQRLLLEVSW 129 Query: 1399 QAAEHSGLGGTILSGTRTGVYVGKDTTGRNEYNNR-VDILDPLKVTSGSTGIL---ASRI 1454 +A E++G+ L+GT+TGV+VG G ++Y R + P+ +GS A R+ Sbjct: 130 EALENAGIAPQKLTGTQTGVFVG---IGIDDYAKRQIKHHIPIDAYTGSGNAFCFAAGRL 186 Query: 1455 AYYLNLNGPCLVVDTACSSSLTAICLATQALKQGQIDIAIVAGVSLAYLP------TQRN 1508 +Y L L GP L +DTACS+SL I LA Q+L+ G+ ++A+ GVSL P ++ Sbjct: 187 SYLLGLQGPSLAIDTACSTSLVTIHLACQSLRNGECNLALAGGVSLMLSPEVTLYLSKTR 246 Query: 1509 SLIDSADEMIRPFDAGANGTMWGEGAGTIILKRMSEAVQDNHVIHAVIKGSEMNNNGTSN 1568 +L S D + FD ANG + GEG G ++LKR+S AV D I AVI+GS +N +G S+ Sbjct: 247 AL--SPDGRCKTFDRDANGYVRGEGCGMVVLKRLSSAVADGDHILAVIRGSAVNQDGASS 304 Query: 1569 GITAPNAEAQEKVLVAAWKAANIDPETISYIEAHATGTKLGDPIEVKGITNAFRRFTNKR 1628 G+T PN AQ+ V+ A A + P ISY+EAH TGT LGDPIEV+ I F + + Sbjct: 305 GLTVPNGTAQQAVIRQALANAKVTPAQISYLEAHGTGTALGDPIEVRAIDGVFGKGRSPN 364 Query: 1629 QFCAAGTVKANIGHLVGASGMASVIKMIMAFKHKQLPPVLQFQNPNPFIEFADSPIYVND 1688 G+VK NIGHL A+GMAS++K+I++ +H+++PP L FQ NP + + + + Sbjct: 365 HPLILGSVKTNIGHLEIAAGMASLLKVILSLQHQEIPPHLNFQELNPDLAASAKSLKIPT 424 Query: 1689 RLQDWSGSAAPRRCGISSFGFSGTNCHILLEEPPVFT-NPQEAKQDWHILALSAKTAGSL 1747 + W + PR GISSFG SGTN HI++EEPP T P E + H+L LSAK+ +L Sbjct: 425 SIIPWQPTEQPRMAGISSFGLSGTNAHIIIEEPPQLTVTPAEVDRPLHVLMLSAKSEAAL 484 Query: 1748 SALIKRYFHMINGTVTLDLQNLCFTANISRGHYEHRIVLLFRTENELR 1795 L + H++ + +L F+AN RG + HR+ ++ ++ + R Sbjct: 485 HTLATDWEHLLRNHPETNFADLAFSANTGRGSFNHRLAIIAQSTAQAR 532 Score = 352 bits (904), Expect = 3e-96, Method: Compositional matrix adjust. Identities = 199/515 (38%), Positives = 298/515 (57%), Gaps = 14/515 (2%) Query: 25 EYITYLQNGNEHRSEEIAVVGISGRFP-KADRVEQFWDNLCSGRDCLDTFPEDR-----L 78 E T +++ ++E IA+VG+ RFP A+ E+FW+ L G+D + T P R Sbjct: 18 EARTKIESLERTQNEPIAIVGMGCRFPGDANNPEKFWELLRQGKDGITTVPPQRWDIDAY 77 Query: 79 HDGQALAPERHLAGGSLKQGGYLDEISFFDAEMFRISPKEALSMEPYQRIMLEVAYDTLV 138 +D P + A + GG+++ + FD + F I+P+EA++++P QR++LEV+++ L Sbjct: 78 YDDDPDVPNKMYA----RYGGFINNVDQFDPQFFGITPREAIALDPQQRLLLEVSWEALE 133 Query: 139 NAGYETQDILGSKTGVF--IGRDHVTGIEYRNYAAPDIFRLTGGWPGILASRISYVYNLK 196 NAG Q + G++TGVF IG D + +++ D + +G A R+SY+ L+ Sbjct: 134 NAGIAPQKLTGTQTGVFVGIGIDDYAKRQIKHHIPIDAYTGSGNAFCFAAGRLSYLLGLQ 193 Query: 197 GPSVVFDTSCSSGLVGLHFACESLRRNECDMAFVGGISGLFYFPPVKEDGSLDQVESAEE 256 GPS+ DT+CS+ LV +H AC+SLR EC++A GG+S L P V S + S + Sbjct: 194 GPSLAIDTACSTSLVTIHLACQSLRNGECNLALAGGVS-LMLSPEVTLYLSKTRALSPDG 252 Query: 257 KIRAFDKAAEGTVWGEGCGGLLLKPLSKAVADKDVIYAVIKGSGINNNGLSKGITAPNGE 316 + + FD+ A G V GEGCG ++LK LS AVAD D I AVI+GS +N +G S G+T PNG Sbjct: 253 RCKTFDRDANGYVRGEGCGMVVLKRLSSAVADGDHILAVIRGSAVNQDGASSGLTVPNGT 312 Query: 317 AQEELLKKVWKQAQINPETIRYIETHGTGTILGDTIELNSIINAFQAFTSKKQFCGVGSV 376 AQ+ ++++ A++ P I Y+E HGTGT LGD IE+ +I F S +GSV Sbjct: 313 AQQAVIRQALANAKVTPAQISYLEAHGTGTALGDPIEVRAIDGVFGKGRSPNHPLILGSV 372 Query: 377 KTNIGHLVGASGIVSLIKAVLMLKHGEIPASLHFQTPSPYINLADSALFINDQRSKLEKG 436 KTNIGHL A+G+ SL+K +L L+H EIP L+FQ +P + + +L I + Sbjct: 373 KTNIGHLEIAAGMASLLKVILSLQHQEIPPHLNFQELNPDLAASAKSLKIPTSIIPWQPT 432 Query: 437 NHPVRIGINSFGFSGTNCHVLLEEPP-VPVYDNNAENNVFLLTLSARSSQKLVEAAQSLQ 495 P GI+SFG SGTN H+++EEPP + V + + +L LSA+S L A + Sbjct: 433 EQPRMAGISSFGLSGTNAHIIIEEPPQLTVTPAEVDRPLHVLMLSAKSEAALHTLATDWE 492 Query: 496 RFLLTNRSVNLADMCCTASQFRNHFANRLAITFSS 530 L + N AD+ +A+ R F +RLAI S Sbjct: 493 HLLRNHPETNFADLAFSANTGRGSFNHRLAIIAQS 527 >BS_pksK_3 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1250 Score = 366 bits (940), Expect = e-100, Method: Compositional matrix adjust. Identities = 338/1290 (26%), Positives = 571/1290 (44%), Gaps = 176/1290 (13%) Query: 39 EEIAVVGISGRFPKADRVEQFWDNLCSGRDCLDTFPEDRL----HDGQALAPERHLAGGS 94 E +A+VGISGRFP A +++FW NL G+D + P+DR H G P+ + Sbjct: 4 EPVAIVGISGRFPGAMDIDEFWKNLEEGKDSITEVPKDRWDWREHYGN---PDTDVNKTD 60 Query: 95 LKQGGYLDEISFFDAEMFRISPKEALSMEPYQRIMLEVAYDTLVNAGYETQDILGSKTGV 154 +K GG++D ++ FD F ISP+EA ++P QR+++ + L +AG Q + G+ TG+ Sbjct: 61 IKWGGFIDGVAEFDPLFFGISPREADYVDPQQRLLMTYVWKALEDAGCSPQSLSGTGTGI 120 Query: 155 FIG------RD--HVTGIEYRNYAAPDIFRLTGGW-PGILASRISYVYNLKGPSVVFDTS 205 FIG +D H + +AA TG P + +R+SY N+ GPS +T+ Sbjct: 121 FIGTGNTGYKDLFHRANLPIEGHAA------TGHMIPSVGPNRMSYFLNIHGPSEPVETA 174 Query: 206 CSSGLVGLHFACESLRRNECDMAFVGGISGLFYFPPVKEDGSLDQVE----SAEEKIRAF 261 CSS LV +H A +++ +C+MA GG++ + + E+ + + S + + + F Sbjct: 175 CSSSLVAIHRAVTAMQNGDCEMAIAGGVNTI-----LTEEAHISYSKAGMLSTDGRCKTF 229 Query: 262 DKAAEGTVWGEGCGGLLLKPLSKAVADKDVIYAVIKGSGINNNGLSKGITAPNGEAQEEL 321 A G V GEG G ++LK L A D + IY VI+G+ N+ G + +T+PN +AQ +L Sbjct: 230 SADANGYVRGEGVGMVMLKKLEDAERDGNHIYGVIRGTAENHGGRANTLTSPNPKAQADL 289 Query: 322 LKKVWKQAQINPETIRYIETHGTGTILGDTIELNSIINAFQAFTSKK---------QFCG 372 L + ++QA I+P T+ YIE HGTGT LGD IE+N + AF+ ++ + CG Sbjct: 290 LVRAYRQADIDPSTVTYIEAHGTGTELGDPIEINGLKAAFKELSNMRGESQPDVPDHRCG 349 Query: 373 VGSVKTNIGHLVGASGIVSLIKAVLMLKHGEIPASLHFQTPSPYINLADSALFINDQRSK 432 +GSVK+NIGHL A+GI LIK +L +KH + SLH +T +PY+ L DS +I ++ + Sbjct: 350 IGSVKSNIGHLELAAGISGLIKVLLQMKHKTLVKSLHCETLNPYLQLTDSPFYIVQEKQE 409 Query: 433 LEK-----GNH-PVRIGINSFGFSGTNCHVLLEE-PPVPVYDNNAENNVFLLTLSARSSQ 485 + GN P R GI+SFG G N H+++EE P ++ A ++ LSA++ Sbjct: 410 WKSVTDRDGNELPRRAGISSFGIGGVNAHIVIEEYMPKANSEHTATEQPNVIVLSAKNKS 469 Query: 486 KLVEAAQSLQRFLLTNRSV--NLADMCCTASQFRNHFANRLAITFSSYEDLLAKLKII-- 541 +L++ A L + + +L + T R RLA + ++L KL+ Sbjct: 470 RLIDRASQLLEVIRNKKYTDQDLHRIAYTLQVGREEMDERLACVAGTMQELEEKLQAFVD 529 Query: 542 --RETKELSLWSSHPGISFQ-LHEVVADTKSQIEAWEIREGEKIALDKTANEAIRELLQK 598 ET E SH Q + D ++AW ++K Sbjct: 530 GKEETDEFFRGQSHRNKETQTIFTADEDMALALDAW---------------------IRK 568 Query: 599 KAGSEMLWEQAARFYIKGASMDWRPLY--PGCRKLAMPGNVLERTKYWPAEAKRGEVYQD 656 + +++ A ++KG S+ W LY R +++P + YW + E + Sbjct: 569 RKYAKL-----ADLWVKGVSIQWNTLYGETKPRLISLPSYPFAKDHYWVPAKEHSERDKK 623 Query: 657 EL----------YYTTEWVEESRLPAGSGAARETVLLIVHEADTALWEAQLPGKLRRKRC 706 EL + T +W S P GS + I+ +TA A++ Sbjct: 624 ELVNAIEDRAACFLTKQW---SLSPIGSAVPGTRTVAILCCQETADLAAEVSSYFPNH-- 678 Query: 707 ILVEIGRPYRKINAEHYHVSNSVEDFSAL-----CGELDISALEQILYAAPSREGLPDSL 761 +L+++ R E+ ++F L CG D L+ I + + Sbjct: 679 LLIDVSR------IENDQSDIDWKEFDGLVDVIGCGWDDEGRLDWIEW-----------V 721 Query: 762 KEFKESFNQTVMNLLYLVKALQAANTMNKDLDIALITRNAHVLQPMDTGSDPFAHTLYGI 821 + E ++ + LL + K L++ N + +A +R G+ Sbjct: 722 QRLVEFGHKEGLRLLCVTKGLESFQ--NTSVRMAGASRA-------------------GL 760 Query: 822 GKSILQENRSFHVRHID---ISNEPADLEALPAELEVPSAQYSVALRHGRRYVEVIKRXX 878 + + E RH+D +++ + + E S V R G RY +K Sbjct: 761 YRMLQCEYSHLISRHMDAEEVTDHRRLAKLIADEFYSDSYDAEVCYRDGLRYQAFLKAHP 820 Query: 879 XXXXXXXXXXXXXXXTFXXXXXXXXXXXEVC-KYLSQKNRVKLIVL-GRTAIPDRESWQS 936 +C ++ ++ VK +VL GR +P RE W Sbjct: 821 ETGKATEQSAVFPKDHVLLITGGTRGIGLLCARHFAECYGVKKLVLTGREQLPPREEWAR 880 Query: 937 IIMDNEDKQLLKKINGILAIEALGFTLDYHCVDICDEAQLRRTVEQIRQDHGSINGVFHC 996 N L +KI + +EA G ++ + + D+AQ+ +T++ I++ G I GV HC Sbjct: 881 FKTSN--TSLAEKIQAVRELEAKGVQVEMLSLTLSDDAQVEQTLQHIKRTLGPIGGVIHC 938 Query: 997 AGVGVGDIEDF-GMSGQEFEQRHAVKTYGSWLVYNLTQEFNTGFTLLFSSAVSITG--GR 1053 AG+ D F + + ++ K G +Y F +LFSS +I Sbjct: 939 AGLTDMDTLAFIRKTSDDIQRVLEPKVSGLTTLYRHVCNEPLQFFVLFSSVSAIIPELSA 998 Query: 1054 GSLAYTAGNAFVDGLAETIRLQGKNVMAINWSTWEATA-SRLSLQA--DKHFFEFLSTHQ 1110 G Y N+++D AE + ++++ W W+ T ++ QA D ++ + Sbjct: 999 GQADYAMANSYMDYFAEAHQKHAP-IISVQWPNWKETGMGEVTNQAYRDSGLLS-ITNSE 1056 Query: 1111 ALQALDLIIRRGMFRTIVGKLNVQNKLLELENLWPFRLA--GEIKQALFPKTRQEERPVR 1168 L+ LD I+ + ++ + Q E E L R G +++A + P R Sbjct: 1057 GLRFLDQIVSKKFGPVVLPAMANQTN-WEPELLMKRRKPHEGGLQEAAL-----QSPPAR 1110 Query: 1169 QTSVTVKEPEGYTATHRELAQVWADILGLTT---------ISVFDSFHQLGGDSIHAAHL 1219 ++E + + L++ + ++ L T + F G DSI A + Sbjct: 1111 D----IEEADEVSKCDGLLSETQSWLIDLFTEELRIDREDFEIDGLFQDYGVDSIILAQV 1166 Query: 1220 HKQWNERHPGTLDVTDIYRYPTIHEMAGYL 1249 ++ N + LD + +Y YPTI A +L Sbjct: 1167 LQRINRKLEAALDPSILYEYPTIQRFADWL 1196 Score = 348 bits (892), Expect = 9e-95, Method: Compositional matrix adjust. Identities = 214/645 (33%), Positives = 342/645 (53%), Gaps = 68/645 (10%) Query: 1298 AESDEYAIIGYACKFPMAEDAEQFWRNLTTGVGAIRPFPESR--------RKDTDGYLAA 1349 A+ + AI+G + +FP A D ++FW+NL G +I P+ R DTD Sbjct: 1 ADFEPVAIVGISGRFPGAMDIDEFWKNLEEGKDSITEVPKDRWDWREHYGNPDTD----V 56 Query: 1350 NQISPEGHAYCQGGYLEEIDRFDSAFFHISPREGELMDPEQRLLLENVYQAAEHSGLGGT 1409 N+ + GG+++ + FD FF ISPRE + +DP+QRLL+ V++A E +G Sbjct: 57 NKTDIK-----WGGFIDGVAEFDPLFFGISPREADYVDPQQRLLMTYVWKALEDAGCSPQ 111 Query: 1410 ILSGTRTGVYVGKDTTGRNEYNNRVDILDPLKVTSGSTGILAS----RIAYYLNLNGPCL 1465 LSGT TG+++G TG + +R ++ P++ + + ++ S R++Y+LN++GP Sbjct: 112 SLSGTGTGIFIGTGNTGYKDLFHRANL--PIEGHAATGHMIPSVGPNRMSYFLNIHGPSE 169 Query: 1466 VVDTACSSSLTAICLATQALKQGQIDIAIVAGVSL-----AYLPTQRNSLIDSADEMIRP 1520 V+TACSSSL AI A A++ G ++AI GV+ A++ + ++ S D + Sbjct: 170 PVETACSSSLVAIHRAVTAMQNGDCEMAIAGGVNTILTEEAHISYSKAGML-STDGRCKT 228 Query: 1521 FDAGANGTMWGEGAGTIILKRMSEAVQDNHVIHAVIKGSEMNNNGTSNGITAPNAEAQEK 1580 F A ANG + GEG G ++LK++ +A +D + I+ VI+G+ N+ G +N +T+PN +AQ Sbjct: 229 FSADANGYVRGEGVGMVMLKKLEDAERDGNHIYGVIRGTAENHGGRANTLTSPNPKAQAD 288 Query: 1581 VLVAAWKAANIDPETISYIEAHATGTKLGDPIEVKGITNAFRRFTNKR---------QFC 1631 +LV A++ A+IDP T++YIEAH TGT+LGDPIE+ G+ AF+ +N R C Sbjct: 289 LLVRAYRQADIDPSTVTYIEAHGTGTELGDPIEINGLKAAFKELSNMRGESQPDVPDHRC 348 Query: 1632 AAGTVKANIGHLVGASGMASVIKMIMAFKHKQLPPVLQFQNPNPFIEFADSPIYVNDRLQ 1691 G+VK+NIGHL A+G++ +IK+++ KHK L L + NP+++ DSP Y+ Q Sbjct: 349 GIGSVKSNIGHLELAAGISGLIKVLLQMKHKTLVKSLHCETLNPYLQLTDSPFYIVQEKQ 408 Query: 1692 DW------SGSAAPRRCGISSFGFSGTNCHILLEE-PPVFTNPQEAKQDWHILALSAKTA 1744 +W G+ PRR GISSFG G N HI++EE P + A + +++ LSAK Sbjct: 409 EWKSVTDRDGNELPRRAGISSFGIGGVNAHIVIEEYMPKANSEHTATEQPNVIVLSAKNK 468 Query: 1745 GSLSALIKRYFHMINGT--VTLDLQNLCFTANISRGHYEHRIVLLFRTENELRAKFKYLQ 1802 L + +I DL + +T + R + R+ + T EL K Sbjct: 469 SRLIDRASQLLEVIRNKKYTDQDLHRIAYTLQVGREEMDERLACVAGTMQELEEKL---- 524 Query: 1803 EAGILQAADRDQRIYYKASRISYDQEGFDGDGLLEQDKLKLNKLAESLIEEWSVEETLSA 1862 +A + + D+ ++ R Q F D E L L+ W + + Sbjct: 525 QAFVDGKEETDEFFRGQSHRNKETQTIFTAD---EDMALALDA--------WIRKRKYA- 572 Query: 1863 VDNLHKIARLYTDGADINWDRLYQGKQHRLTELPAYAYEPVRHWI 1907 K+A L+ G I W+ LY + RL LP+Y + +W+ Sbjct: 573 -----KLADLWVKGVSIQWNTLYGETKPRLISLPSYPFAKDHYWV 612 Score = 150 bits (380), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 125/457 (27%), Positives = 216/457 (47%), Gaps = 40/457 (8%) Query: 2080 GMAKVIPQEYPQFKCRCIDIDSATAPATVWK----EICSGKGDFQVAYRDNTRYLEHFGE 2135 G+ +++ EY R +D + T + K E S D +V YRD RY + F + Sbjct: 759 GLYRMLQCEYSHLISRHMDAEEVTDHRRLAKLIADEFYSDSYDAEVCYRDGLRY-QAFLK 817 Query: 2136 RRLEAAEAGGVS--LKENGVYVVTGGLGGIGLAVAQYLSGKQRVH-LCLLNRRTLPPG-- 2190 E +A S ++ V ++TGG GIGL A++ + V L L R LPP Sbjct: 818 AHPETGKATEQSAVFPKDHVLLITGGTRGIGLLCARHFAECYGVKKLVLTGREQLPPREE 877 Query: 2191 -----------PSQSQRIRQIEANGSDVDLYSVDISAPNELQGVLQAIRTKYGQINGLFH 2239 + Q +R++EA G V++ S+ +S +++ LQ I+ G I G+ H Sbjct: 878 WARFKTSNTSLAEKIQAVRELEAKGVQVEMLSLTLSDDAQVEQTLQHIKRTLGPIGGVIH 937 Query: 2240 CAGIAGEGLL--INKGKPEIKRVLDAKVTGTWLLDQYTAQDHLDYFVLFSSVTSLLGGM- 2296 CAG+ L I K +I+RVL+ KV+G L ++ + L +FVLFSSV++++ + Sbjct: 938 CAGLTDMDTLAFIRKTSDDIQRVLEPKVSGLTTLYRHVCNEPLQFFVLFSSVSAIIPELS 997 Query: 2297 -GQADYTAANAYLDGFSDYRQANNRRSVTINWPAWKEVGMTLKYDIQEGRSPFLGLTEEQ 2355 GQADY AN+Y+D F++ Q + +++ WP WKE GM + S L +T + Sbjct: 998 AGQADYAMANSYMDYFAEAHQ-KHAPIISVQWPNWKETGMGEVTNQAYRDSGLLSITNSE 1056 Query: 2356 GISILDAVLQRKLSRIIAGEINERYFQNGDPSLPFAVPPQMISRGTGAFNPQEKVIADEP 2415 G+ LD ++ +K ++ + + N +P L M R QE + P Sbjct: 1057 GLRFLDQIVSKKFGPVVLPAMANQ--TNWEPEL------LMKRRKPHEGGLQEAALQSPP 1108 Query: 2416 ILPILKG----RYDHSYNSYEISLAAMWQKVLGVAEVNVHLP--FQETGGNSILATSLVK 2469 I + + D + + L ++ + L + + + FQ+ G +SI+ +++ Sbjct: 1109 ARDIEEADEVSKCDGLLSETQSWLIDLFTEELRIDREDFEIDGLFQDYGVDSIILAQVLQ 1168 Query: 2470 EIDGVYPGCVNIATLFAYPSIAKMAEYLKQKQSENES 2506 I+ ++ + L+ YP+I + A++L SE S Sbjct: 1169 RINRKLEAALDPSILYEYPTIQRFADWLIGSYSERLS 1205 >all2646 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1488 Score = 357 bits (916), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 206/510 (40%), Positives = 286/510 (56%), Gaps = 30/510 (5%) Query: 1302 EYAIIGYACKFPMAEDAEQFWRNLTTGVGAIRPFPESRRKDTDGYLAANQISPEGHAYC- 1360 E AIIG KFP A + E++W+NL GV ES TD + N + P + Sbjct: 8 EIAIIGINGKFPGANNLEEYWQNLRNGV-------ESITNLTDEQIQKNGVDPTQLKHPN 60 Query: 1361 ---QGGYLEEIDRFDSAFFHISPREGELMDPEQRLLLENVYQAAEHSGLGGTILSGTRTG 1417 + ++ I+ FD+ FF +PRE E++DP+ RL LE + A E +G +G G Sbjct: 61 YVKRQAIIDNIEYFDAEFFGFNPREAEILDPQHRLFLECAWTALEDAGYNPENYTGA-IG 119 Query: 1418 VYVGK-------DTTGRNEYNNRVDILDPLKVTSGSTGILASRIAYYLNLNGPCLVVDTA 1470 VY G + + N++ S L +R++Y LNL GP L + TA Sbjct: 120 VYAGAAMNNYLLNLITNPQIQNQISRYQLF--LSNDKDFLTTRVSYKLNLRGPSLDIQTA 177 Query: 1471 CSSSLTAICLATQALKQGQIDIAIVAGVSLA----YLPTQRNSLIDSADEMIRPFDAGAN 1526 CS+SL A+ +A Q+L G+ DIA+ GVSLA YL + I S D R FDA A Sbjct: 178 CSTSLVAVHVACQSLLSGECDIALAGGVSLAKATGYL--YQEGGIYSPDGHCRAFDADAQ 235 Query: 1527 GTMWGEGAGTIILKRMSEAVQDNHVIHAVIKGSEMNNNG-TSNGITAPNAEAQEKVLVAA 1585 GT+ G G G ++LKR+ EA++D IHAVIKGS +NN+G TAP + Q V+ AA Sbjct: 236 GTIAGSGLGIVVLKRLQEAIEDRDYIHAVIKGSAINNDGGLKVSYTAPRIDTQAAVIRAA 295 Query: 1586 WKAANIDPETISYIEAHATGTKLGDPIEVKGITNAFRRFTNKRQFCAAGTVKANIGHLVG 1645 A ++P ISYIE H TGT LGDPIE+ +T AFR T K FCA +VK NIGHL Sbjct: 296 QALAGVEPADISYIETHGTGTALGDPIEIAALTQAFRAGTEKTGFCAISSVKTNIGHLDA 355 Query: 1646 ASGMASVIKMIMAFKHKQLPPVLQFQNPNPFIEFADSPIYVNDRLQDWSGSAAPRRCGIS 1705 A+G+AS+IK ++A KH+Q+PP L FQ PNP I+F+ +P YVN L DW PRR G+S Sbjct: 356 AAGIASLIKTVLALKHQQIPPNLHFQQPNPQIDFSQTPFYVNTNLVDWETDKTPRRAGVS 415 Query: 1706 SFGFSGTNCHILLEEPPVFTNPQEA--KQDWHILALSAKTAGSLSALIKRYFHMINGTVT 1763 SFG GTN H++LEE P+ Q + K ++ +L LSAK+ +L + Sbjct: 416 SFGIGGTNAHVILEEAPIKFKIQNSKFKINYQMLCLSAKSEKALEEATINLATYLQQHPQ 475 Query: 1764 LDLQNLCFTANISRGHYEHRIVLLFRTENE 1793 +L ++ +T +I R H+ +R ++L +T E Sbjct: 476 FNLADIAYTLHIGRQHFAYRRMVLCQTTEE 505 Score = 352 bits (904), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 207/533 (38%), Positives = 304/533 (57%), Gaps = 25/533 (4%) Query: 40 EIAVVGISGRFPKADRVEQFWDNLCSGRDCLDTFPEDRLHDGQALAPERHLAGGSLKQGG 99 EIA++GI+G+FP A+ +E++W NL +G + + ++++ + P + +K+ Sbjct: 8 EIAIIGINGKFPGANNLEEYWQNLRNGVESITNLTDEQIQKN-GVDPTQLKHPNYVKRQA 66 Query: 100 YLDEISFFDAEMFRISPKEALSMEPYQRIMLEVAYDTLVNAGYETQDILGSKTGVFIGR- 158 +D I +FDAE F +P+EA ++P R+ LE A+ L +AGY ++ G+ GV+ G Sbjct: 67 IIDNIEYFDAEFFGFNPREAEILDPQHRLFLECAWTALEDAGYNPENYTGA-IGVYAGAA 125 Query: 159 ------DHVTGIEYRNYAAPDIFRLTGGWPGILASRISYVYNLKGPSVVFDTSCSSGLVG 212 + +T + +N + L+ L +R+SY NL+GPS+ T+CS+ LV Sbjct: 126 MNNYLLNLITNPQIQNQISRYQLFLSND-KDFLTTRVSYKLNLRGPSLDIQTACSTSLVA 184 Query: 213 LHFACESLRRNECDMAFVGGISGLFYFPPVKEDGSLDQ---VESAEEKIRAFDKAAEGTV 269 +H AC+SL ECD+A GG+S K G L Q + S + RAFD A+GT+ Sbjct: 185 VHVACQSLLSGECDIALAGGVS------LAKATGYLYQEGGIYSPDGHCRAFDADAQGTI 238 Query: 270 WGEGCGGLLLKPLSKAVADKDVIYAVIKGSGINNNG-LSKGITAPNGEAQEELLKKVWKQ 328 G G G ++LK L +A+ D+D I+AVIKGS INN+G L TAP + Q +++ Sbjct: 239 AGSGLGIVVLKRLQEAIEDRDYIHAVIKGSAINNDGGLKVSYTAPRIDTQAAVIRAAQAL 298 Query: 329 AQINPETIRYIETHGTGTILGDTIELNSIINAFQAFTSKKQFCGVGSVKTNIGHLVGASG 388 A + P I YIETHGTGT LGD IE+ ++ AF+A T K FC + SVKTNIGHL A+G Sbjct: 299 AGVEPADISYIETHGTGTALGDPIEIAALTQAFRAGTEKTGFCAISSVKTNIGHLDAAAG 358 Query: 389 IVSLIKAVLMLKHGEIPASLHFQTPSPYINLADSALFINDQRSKLEKGNHPVRIGINSFG 448 I SLIK VL LKH +IP +LHFQ P+P I+ + + ++N E P R G++SFG Sbjct: 359 IASLIKTVLALKHQQIPPNLHFQQPNPQIDFSQTPFYVNTNLVDWETDKTPRRAGVSSFG 418 Query: 449 FSGTNCHVLLEEPPVPVYDNNAEN--NVFLLTLSARSSQKLVEAAQSLQRFLLTNRSVNL 506 GTN HV+LEE P+ N++ N +L LSA+S + L EA +L +L + NL Sbjct: 419 IGGTNAHVILEEAPIKFKIQNSKFKINYQMLCLSAKSEKALEEATINLATYLQQHPQFNL 478 Query: 507 ADMCCTASQFRNHFANRLAITFSSYEDLLAKLKIIRETKELSLWSSH-PGISF 558 AD+ T R HFA R + + E+ L+ +ETK S P I+F Sbjct: 479 ADIAYTLHIGRQHFAYRRMVLCQTTEEAAQILE--KETKYTHTNSEKSPSIAF 529 Score = 169 bits (427), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 156/638 (24%), Positives = 283/638 (44%), Gaps = 79/638 (12%) Query: 1866 LHKIARLYTDGADINWDRLYQGKQHRLTELPAYAYEPVRHWI----GGSARKGSSSPGKY 1921 L + +L+ G I+W+ Y +Q + LP Y ++ R+WI G + SP + Sbjct: 838 LQTLGQLWLAGVSIDWENFYTHQQRQRLPLPTYPFQRQRYWIDLKAGEQGSENIPSP-RL 896 Query: 1922 YQLQWLPDHREQPAGIKPDEGAWLFVGGTGTKSQELLRVLRKQEIELIEVTPGARYHQLA 1981 Y W I WL QE++ L+ ++I V+ G +Y Q A Sbjct: 897 YLPSWERSLPHPQVDIAEKRLCWLVFTDNYGIYQEIINTLQAVGHDVIIVSQGEKYDQPA 956 Query: 1982 ANRYSIG--SGEEYSLLLKELSNRGI--KHVIHCLSLADEKIAGIEDLHAAENRGVYNLH 2037 +++ + +++ L +L R + H+++ L D + + +L Sbjct: 957 YRTFTVNPQNSQDFVELWSDLELRELIPHHILYLWDLTDLQ------------QQPLSLL 1004 Query: 2038 HLVTALLNGQYHQELNLFFVADHTFLVNRHEPVLNPHHAVLFGMAKVIPQEYPQFKCRCI 2097 +L A+ + +E+ L V + L+ +E + P A ++GM KVI QE PQ CRC+ Sbjct: 1005 YLAQAISSQSIEREITLTLVTNDGQLLLGNENI-QPMKATVWGMGKVISQEIPQLTCRCV 1063 Query: 2098 DIDSATAPAT-------VWKEICSGKGDFQVAYRDNTRYLEHFGERRLEAAEAGGVSLKE 2150 DI +T +T + E + + D VAYR N R+ + + ++ A++ +S+ E Sbjct: 1064 DISLSTVASTNEQIAQQLITECLNNQNDSVVAYRGNYRWNQIYKPLLMDDAQSK-ISVHE 1122 Query: 2151 NGVYVVTGGLG-GIGLAVAQYLSGKQRVHLCLLNRRTLPPGPSQSQRIRQ-IEANGSDVD 2208 G YV+ G L G+G A++L K V L LL+ ++ ++Q ++ G D Sbjct: 1123 GGNYVILGDLTTGLGTVFAEFLM-KNSVRLVLLSDVI-------TETLKQSLDNVGIDYL 1174 Query: 2209 LYSVDISAPNELQGVLQAIRTKYGQINGLFHCAGIAGE---GLLINKGKPEIKRVLDAKV 2265 ++DI+ EL+ + TK+GQING+F+ ++ E L + K+ Sbjct: 1175 SLNIDITKQAELENAIAQAETKFGQINGVFYSTPMSNEHSMAFLPQLTTKHWEYNYRTKI 1234 Query: 2266 TGTWLLDQYTAQDHLDYFVLFSSVTSLLGGMGQADYTAANAYLDGFSDYRQANNRRS-VT 2324 G +L + LD+ VL SS++++LGG+G A Y AANA +D F+ + N++ ++ Sbjct: 1235 QGLCVLAEVLRDKPLDFCVLQSSLSTVLGGLGLAVYAAANAVIDMFAIQQNQNSKFPWIS 1294 Query: 2325 INWPAWKEVGMTLKYDIQEGRSPFLGLTEEQGISILDAVLQRKLSRIIAGEINERYFQNG 2384 INW A + L+ DI + L +++ A + + II Sbjct: 1295 INWDACRS---DLETDINHSFAANL-----VTLALTPAEVWQSTQHIIK----------- 1335 Query: 2385 DPSLPFAVPPQMISRGTGAFNPQEKVIADEP-----------ILPILKGRYDHSYNSYEI 2433 +P ++ + EK + + P P L Y + E Sbjct: 1336 -----LGLPESVVVTKSDLDKRLEKWVTNTPTKTKTETNNSYTRPQLTNEYIAPRDEIET 1390 Query: 2434 SLAAMWQKVLGVAEVNVHLPFQETGGNSILATSLVKEI 2471 ++A +WQ +LG++ + ++ F + GG+S+LA + + Sbjct: 1391 AIAQIWQDLLGISPIGINDSFFDLGGHSLLAIQAISRL 1428 Score = 91.3 bits (225), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 141/652 (21%), Positives = 250/652 (38%), Gaps = 79/652 (12%) Query: 591 AIRELLQKKAGSEMLWEQAARFYIKGASMDWRPLYPGCRK--LAMPGNVLERTKYWPAEA 648 ++R ++ L + + ++ G S+DW Y ++ L +P +R +YW + Sbjct: 823 SLRHPQDTQSDVAFLLQTLGQLWLAGVSIDWENFYTHQQRQRLPLPTYPFQRQRYW-IDL 881 Query: 649 KRGEVYQDEL----YYTTEWVEESRLPAGSGAARETVLLIVHEADTALWEAQLPGKLRRK 704 K GE + + Y W P A + L+ + E + Sbjct: 882 KAGEQGSENIPSPRLYLPSWERSLPHPQVDIAEKRLCWLVFTDNYGIYQEIINTLQAVGH 941 Query: 705 RCILVEIGRPYRKINAEHYHVS-NSVEDFSALCGELDISALEQILYAAPSREGLPDSLKE 763 I+V G Y + + V+ + +DF L +L++ RE +P + Sbjct: 942 DVIIVSQGEKYDQPAYRTFTVNPQNSQDFVELWSDLEL------------RELIPHHILY 989 Query: 764 FKE--SFNQTVMNLLYLVKALQAANTMNKDLDIALITRNAHVLQPMDTGSDPFAHTLYGI 821 + Q ++LLYL +A+ ++ ++ +++ + L+T + +L + P T++G+ Sbjct: 990 LWDLTDLQQQPLSLLYLAQAI-SSQSIEREITLTLVTNDGQLLLG-NENIQPMKATVWGM 1047 Query: 822 GKSILQENRSFHVRHIDIS-------NEPADLEALPAELEVPSAQYSVALRHGRRYVEVI 874 GK I QE R +DIS NE + L E VA R R+ ++ Sbjct: 1048 GKVISQEIPQLTCRCVDISLSTVASTNEQIA-QQLITECLNNQNDSVVAYRGNYRWNQIY 1106 Query: 875 KRXXXXXXXXXXXXXXXXXTFXXXXXXXXXXXEVCKYLSQKNRVKLIVLGRTAIPDRESW 934 K ++L KN V+L++L Sbjct: 1107 KPLLMDDAQSKISVHEGGNYVILGDLTTGLGTVFAEFL-MKNSVRLVLL----------- 1154 Query: 935 QSIIMDNEDKQLLKKINGILAIEALGFTLDYHCVDICDEAQLRRTVEQIRQDHGSINGVF 994 S ++ KQ L + I+ L +DI +A+L + Q G INGVF Sbjct: 1155 -SDVITETLKQSLDNV----GIDYLSLN-----IDITKQAELENAIAQAETKFGQINGVF 1204 Query: 995 HCAGVGVGDIEDF--GMSGQEFEQRHAVKTYGSWLVYNLTQEFNTGFTLLFSSAVSITGG 1052 + + F ++ + +E + K G ++ + ++ F +L SS ++ GG Sbjct: 1205 YSTPMSNEHSMAFLPQLTTKHWEYNYRTKIQGLCVLAEVLRDKPLDFCVLQSSLSTVLGG 1264 Query: 1053 RGSLAYTAGNAFVDGLAETIRLQGKNVMAINWST--WEATASRLSLQADKHFFEFLST-- 1108 G Y A NA +D A +Q W + W+A S L + F L T Sbjct: 1265 LGLAVYAAANAVIDMFA----IQQNQNSKFPWISINWDACRSDLETDINHSFAANLVTLA 1320 Query: 1109 ---HQALQALDLIIRRGMFRTIV-GKLNVQNKLLELENLWPFRLAGEIKQALFPKTRQEE 1164 + Q+ II+ G+ ++V K ++ +L + P + E + Sbjct: 1321 LTPAEVWQSTQHIIKLGLPESVVVTKSDLDKRLEKWVTNTPTKTKTETNNSY-------T 1373 Query: 1165 RPVRQTSVTVKEPEGYTATHRELAQVWADILGLTTISVFDSFHQLGGDSIHA 1216 RP E TA +AQ+W D+LG++ I + DSF LGG S+ A Sbjct: 1374 RPQLTNEYIAPRDEIETA----IAQIWQDLLGISPIGINDSFFDLGGHSLLA 1421 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.135 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 192,398,790 Number of extensions: 8405845 Number of successful extensions: 18182 Number of sequences better than 1.0e-05: 127 Number of HSP's gapped: 17429 Number of HSP's successfully gapped: 280 Length of query: 2551 Length of database: 38,378,431 Length adjustment: 123 Effective length of query: 2428 Effective length of database: 24,192,349 Effective search space: 58739023372 Effective search space used: 58739023372 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 125 (52.8 bits)