BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0489.0015.p (2806 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_ppsA_2 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 578 e-164 PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and ... 506 e-142 PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 506 e-142 all2644_1 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 504 e-142 all2646 [Q] COG3321 Polyketide synthase modules and related prot... 499 e-140 >BS_ppsA_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Length = 792 Score = 578 bits (1491), Expect = e-164, Method: Compositional matrix adjust. Identities = 0/1067 (0%), Positives = 0/1067 (0%), Gaps = 69/1067 (6%) Query: 1727 YPTSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRA 1786 P L ++ + + + ++ L S Sbjct: 7 SPLVLWYNQLGMNDVDRVGGKNASLGEMITNLSGMGVSVPNGFATTADAFNQFLDQSGVN 66 Query: 1787 E-NGEIVQIIHPHVDFKLIRTAVKEQGIEEAVERFIQPFDLARAPLIRVGLLQAGEQQSI 1845 + E++ +L + + + + + R ++ ++ Sbjct: 67 QRIYELLDKTDIDDVTQLAKAGAQIRQWIIDTPFQPELENAIREAYAQLSADDENASFAV 126 Query: 1846 LVVDMHHIIADGTSVNLLVNDFADLYMGKILPPLAIQYKDYAEWQQGFITSEAYRSKETY 1905 + D + +L + + + Sbjct: 127 RSSATAEDMPDASFAGQQETFLNVQGFDAVLVAVKHVFASLFNDRAISYRVHQGYDHRGV 186 Query: 1906 WLEKLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMTMXX 1965 L + L + + + G + + F Sbjct: 187 ALSAGVQRMVRSDLASSGVMFSIDTESGFDQVVFITSAWGLGEMVVQGAVNPDEFYVHKP 246 Query: 1966 XXXXXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFL 2025 + I ++ + V + R+ + L Sbjct: 247 TLAANRPAIVRRTMGSKKIRMVYAPTQEHGKQVKIEDVPQEQRDIF----SLTNEEVQEL 302 Query: 2026 QEVRASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDM 2085 + + + + + + Sbjct: 303 AKQAVQIEKHYGRPMDIEWAKDGHTGKLFIVQARPETVRSRGQVMERYTLHS----QGKI 358 Query: 2086 KLSPYPMTSKTTKADLNIHLYEVPSGIYVECFYRTDLFKRETVQYI---FEEYRRLIEAI 2142 + + + + + I Sbjct: 359 IAEGRAIGHRIGAGPVKVIHDISEMNRIEPGDVLVTDMTDPDWEPIMKKASAIVTNRGGR 418 Query: 2143 PEQAGRTIGELPVFRQNDIPPAGGNVSPPVRFQAFHYNDPAENLVQR-------FEKQVA 2195 A EL + + A Sbjct: 419 TCHAAIIARELGIPAVVGC--------------GDATERMKDGENVTVSCAEGDTGYVYA 464 Query: 2196 AYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVALLFGNTIEMVAALAG 2255 + E++ L N + + ++ + G Sbjct: 465 ELLEFSVKSSSVETMPDLPLKVMMNVGNPD---RAFDFACLPNEGVGLARLEFIINRMIG 521 Query: 2256 AIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSENESIARELAERVHAKVTIVNTAE 2315 + + M+ + L + K IV Sbjct: 522 VHPRALLEFDDQEPQLQNEIREMMKGFDSPREFYVGRLTEGIATLGAAFYPKRVIVR--L 579 Query: 2316 GLSGVSAENPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQD- 2374 + V + + G G + V S+R+ + Sbjct: 580 SDFKSNEYANLVGGERYEPDEENPMLGFRGAGRYVSDSFRD-------CFALECEAVKRV 632 Query: 2375 -------RMALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSSWLNSEGITLY 2427 + ++ + + + L L + L + Sbjct: 633 RNDMGLTNVEIMIPFVRTVDQAKAVVEELARQGLKRGENGLKIIMMCEIPSNALLAEQFL 692 Query: 2428 HSVPS----VFRFLMKNLPGDVKLPSLRMVLLGGEVVTRADFELYKKNCAEHCLFVNFLG 2483 +V + A L ++G Sbjct: 693 EYFDGFSIGSNDMTQLA---LGLDRDSGVVSELFDERNDAVKALLSMAIRAAKKQGKYVG 749 Query: 2484 CSELMV-ISFYTLDKGSEVNHARLPAGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEYL 2542 Sbjct: 750 ICGQGPS 809 Query: 2543 SPGYWNQAGVTERVFASGPDSGAKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDL 2602 Sbjct: 810 869 Query: 2603 NEIESTLDHIPFIQQSIVTATLDHEGEQAIAAYYVLKEPAAEKDIIR-LLREQLPAYLIP 2661 Sbjct: 870 -- 927 Query: 2662 RYWIELKFFPMTGPNKVDRNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQH 2721 Sbjct: 928 ---- 983 Query: 2722 IGVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTISSLA 2768 Sbjct: 984 - 1029 Score = 98.6 bits (244), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 0/324 (0%), Positives = 0/324 (0%), Gaps = 50/324 (15%) Query: 1618 PVTRKSQGKRPELPVA-------YVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGD 1670 Sbjct: 937 996 Query: 1671 SLKAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRN-ASRAN------ERQIAPVNP 1723 Sbjct: 997 --- 1053 Query: 1724 KSHYPTSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTS 1783 Sbjct: 1054 ----------- 1102 Query: 1784 F-RAENGEIVQIIH--PHVDFKLI--------RTAVKEQGIEE---AVERFIQ-PFDLAR 1828 Sbjct: 1103 1162 Query: 1829 APLIRVGLLQAGEQQSILVVDMHHIIADGTSVNLLVNDFADLYMGKI------LPPLAIQ 1882 Sbjct: 1163 - 1221 Query: 1883 YKDYAEWQQGFITSEAYRSKETYW 1906 Sbjct: 1222 1245 >PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Length = 346 Score = 506 bits (1304), Expect = e-142, Method: Compositional matrix adjust. Identities = 0/1164 (0%), Positives = 0/1164 (0%), Gaps = 77/1164 (6%) Query: 1642 EKKLCAIYENHLGFQPIGIEDDFFELSGDSLKAIHVISSIRKQFDCNLTLTDFFQNKTIK 1701 L + + I ++ + + +T+ + + Sbjct: 155 VSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRS 214 Query: 1702 SVARFIRNASRANERQIAPVNPKSHYPTSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNI 1761 S+ ++ + + G S Sbjct: 215 FEVGLA-EVSQYEGVELLAYSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKA 273 Query: 1762 NAGRIEEVFAQIINRHESLRTSFRAENGEIVQIIHPHVDFKLIR---TAVKEQGIEEAVE 1818 A ++ ++ + R + ++ +L + E + E Sbjct: 274 VAAYVDIARRHGLDPAQMALAFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAE 333 Query: 1819 -RFIQPFDLARAPLIRVGLLQAGEQQSILVVDMHHIIADGTSVNLLVNDFADLYMG---- 1873 Sbjct: 334 I 393 Query: 1874 --KILPPLAIQYKDYAEWQQGFITSEAYRSKETYWLEKLAGPLPVLTLPTDYPRPAALSF 1931 Sbjct: 394 453 Query: 1932 QGGRITLELDRPSSERIKKFSQEQQVTWFMTMXXXXXXXXXXXSGESDILIGIPQAGRNH 1991 Sbjct: 454 513 Query: 1992 EDVQEMVGMFVNSLVLRNQPXXXXERKKPFLAFLQEVRASLLEALENQDFQIEMIVDQLD 2051 Sbjct: 514 ---- 569 Query: 2052 YKRDPGRTFLYDTIFNYQSMKNQTETEASYLHDMKLSPYPMTSKTTKADLNIHLYEVPSG 2111 Sbjct: 570 -- 627 Query: 2112 IYVECFYRTDLFKRETVQYIFEEYRRLIEAIPEQAGRTIGELPVFRQNDIPPAGGNVSPP 2171 Sbjct: 628 ------ 681 Query: 2172 VRFQAFHYND---PAENLV-QRFEKQVAAYPAHTAVKYREESLNYRQLNEQANRIARRIW 2227 Sbjct: 682 ---- 737 Query: 2228 ELKEQESVERPVALLFGNTIEMVAALAGAIKAGIPFVPLDRSAPLQRLIHMVNDAQA--- 2284 Sbjct: 738 - 796 Query: 2285 TLILTDSENESIARELAERVHAKVTIVNTAEGLSGVSAENPSVCPDGDQTAFILYTSGSS 2344 Sbjct: 797 ------ 850 Query: 2345 GIPKGVVQSYRNIAFYIAQFTHSLAVNHQDRMALLTTYSHAIGILDILASLLNGATLHLC 2404 Sbjct: 851 910 Query: 2405 DLKLDASIQRLSSWLNSEGITLYHSVPSVFRFLMKNLPGDVKLPSLRMVLLGGEVVTRAD 2464 Sbjct: 911 - 969 Query: 2465 FELYKKNCAEHCLFVNFLGCSELMVIS-FYTLDKGSEVNHARLP--------AGYAVDG- 2514 Sbjct: 970 - 1028 Query: 2515 IDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQAGVTERVFASGP-DSGAKRLYRSGD 2573 Sbjct: 1029 --------- 1079 Query: 2574 YGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATLDHEGEQAIA 2633 Sbjct: 1080 - 1138 Query: 2634 AYYVLKEPA----------AEKDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNAL 2683 Sbjct: 1139 1198 Query: 2684 PAPDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQN 2743 Sbjct: 1199 --- 1255 Query: 2744 NLEKELKLTVEMGDLFKYPTISSL 2767 Sbjct: 1256 1279 Score = 142 bits (358), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 10/215 (4%), Positives = 35/215 (16%), Gaps = 15/215 (6%) Query: 2567 RLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATLDH 2626 L + AQ ++ + + + Sbjct: 17 GLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETY---VGNWL 73 Query: 2627 EGEQAIAAYYV-------LKEPAAEKDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVD 2679 + + +K I + + Sbjct: 74 AKH--GSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQV 131 Query: 2680 RNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLM 2739 + ++L L + + ++ Sbjct: 132 HWPQRPTNC---FGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMR 188 Query: 2740 QVQNNLEKELKLTVEMGDLFKYPTISSLATFLKDK 2774 + + +L V + + + S + Sbjct: 189 YLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVS 223 >PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Length = 346 Score = 506 bits (1303), Expect = e-142, Method: Compositional matrix adjust. Identities = 0/1072 (0%), Positives = 0/1072 (0%), Gaps = 56/1072 (5%) Query: 1730 SLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTSFRAENG 1789 + + L N + + + + R + Sbjct: 7 PHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTE 66 Query: 1790 EIVQIIHPHVDFKLIRTAVKEQGIEEAVERFI-QPFDLARAPLIRVGLLQAGEQQSILVV 1848 V + + +P IR L + ++ + Sbjct: 67 TYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYL 126 Query: 1849 DMHHIIADGTSVNLLVNDFADLY------MGKILPPLAIQYKDYAEWQQGFITSEAYRSK 1902 D++ + N +Y+ + + +++E Sbjct: 127 DLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGV 186 Query: 1903 ETYWLEKLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQQVTWFMT 1962 Y LP + + SF+ G + +T Sbjct: 187 MRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKYL 246 Query: 1963 MXXXXXXXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXXERKKPFL 2022 G V ++ + R++PF+ Sbjct: 247 NGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMA----LAFVRRQPFV 302 Query: 2023 AFLQEVRASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQTETEASYL 2082 Sbjct: 303 - 361 Query: 2083 HDMKLSPYPMTSKTTKADLNIHLYEVPSGIYVECFYRTDLFKRETVQYIFEEYRRLIEAI 2142 Sbjct: 362 421 Query: 2143 PEQAGRTIGELPVFRQNDIPPAGGNVSPPVRFQAFHYNDPAE-------NLVQRFEKQVA 2195 Sbjct: 422 ------------ 469 Query: 2196 AYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVALLFGNTIEMVAALAG 2255 Sbjct: 470 -- 527 Query: 2256 AIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSE-NESIARELAERVHAKVTIVNTA 2314 Sbjct: 528 --- 584 Query: 2315 EGLSGVSAENPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNIAFYIAQFTHSLAVNHQD 2374 Sbjct: 585 -- 642 Query: 2375 RMALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSSWLNSEGITLYHSVPSVF 2434 Sbjct: 643 702 Query: 2435 RFLMK-NLPGDV--KLPSLRMVLLGGEVVTRADFE-LYKKNCAEHCLFVNFLGCSELMV- 2489 Sbjct: 703 762 Query: 2490 ISFYTLDKGSEVNHARLPAGYAVDGIDVRIVGESGREAGIFEVGQLVYQSEYLSPGYWNQ 2549 Sbjct: 763 822 Query: 2550 AGVTERVFASGPDSG--AKRLYRSGDYGRLLPNGCLEYHGRNDAQLKIRGYRVDLNEIES 2607 Sbjct: 823 882 Query: 2608 TLDHIPFIQQSIVTATLDHEGEQAIAAYYVLKEPAAEKDIIR-----LLREQLPAYLIPR 2662 Sbjct: 883 -- 940 Query: 2663 YWIELKFFPMTGPNKVDRNALPAPDAIPSNDLRHEYVPPRNEMENMLARLWGEVLGIQHI 2722 Sbjct: 941 --- 997 Query: 2723 GVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTISSLATFLKDK 2774 Sbjct: 998 1049 >all2644_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Length = 346 Score = 504 bits (1299), Expect = e-142, Method: Compositional matrix adjust. Identities = 0/1092 (0%), Positives = 0/1092 (0%), Gaps = 86/1092 (7%) Query: 1724 KSHYPTSLAQKRIFFLQGLMPDTVGYNESTSVLLEGNINAGRIEEVFAQIINRHESLRTS 1783 S A + + + + + E + R Sbjct: 22 TFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSREK 81 Query: 1784 FRAENGEIVQIIHPHVDFKLIRTAVKE--------QGIEEAVERFIQPFDLARAPLIRVG 1835 + + + + ++ + Sbjct: 82 LIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPTNCF 141 Query: 1836 LLQAGEQQSILVVDMHHIIADGTSVNLLVNDFADLYMGKILPPLAIQYKDYAEWQQGFIT 1895 D + + + ++Y A+ Sbjct: 142 GKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLHLADKHDLPRI 201 Query: 1896 SEAYRSKETYWLEKLAGPLPVLTLPTDYPRPAALSFQGGRITLELDRPSSERIKKFSQEQ 1955 G V + G L+ + + Sbjct: 202 VTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKYLNGAKPAGARNTLFSR 261 Query: 1956 QVTWFMTMXXXXXXXXXXXSGESDILIGIPQAGRNHEDVQEMVGMFVNSLVLRNQPXXXX 2015 + + + + + + + + Sbjct: 262 FTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQPFVASTLLGATTMDQLK----T 317 Query: 2016 ERKKPFLAFLQEVRASLLEALENQDFQIEMIVDQLDYKRDPGRTFLYDTIFNYQSMKNQT 2075 Sbjct: 318 377 Query: 2076 ETEASYLHDMKLSPYPMTSKTTKADLNIHLYEVPSGIYVECFYRTDLFKRETVQYIFEEY 2135 Sbjct: 378 ---- 433 Query: 2136 RRLIEAIPEQAGRTIGELPVFRQNDIPPAGGNVSPPVRFQAF--HYND-----PAENLVQ 2188 Sbjct: 434 -------------- 479 Query: 2189 RFEKQVAAYPAHTAVKYREESLNYRQLNEQANRIARRIWELKEQESVERPVALLFGNTIE 2248 Sbjct: 480 -- 537 Query: 2249 MVAALAGAIKAGIPFVPLDRSAPLQRLIHMVNDAQATLILTDSE---NESIARELAERVH 2305 Sbjct: 538 597 Query: 2306 AKVTIVNTA--------EGLSGVSAENPSVCPDGDQTAFILYTSGSSGIPKGVVQSYRNI 2357 Sbjct: 598 -- 655 Query: 2358 AFYIAQFTHSLAVNHQDRMALLTTYSHAIGILDILASLLNGATLHLCDLKLDASIQRLSS 2417 Sbjct: 656 715 Query: 2418 WLNSEGITLYHSVPSVFRFLMKN-LPGDVKLPSLRMVLLGGEVVTRADFELYKK--NCAE 2474 Sbjct: 716 ------- 768 Query: 2475 HCLFVNFLGCSELMVISF---YTLDKGSEVNHARLPAGYAVDGIDVRIVGESGREAGIFE 2531 Sbjct: 769 --------- 819 Query: 2532 VGQLVYQSEYLSPGYWNQAGVTERVF------ASGPDSGAKRLYRSGDYGRLLPNGCLEY 2585 Sbjct: 820 879 Query: 2586 HGRNDAQLKIRGYRVDLNEIESTLDHIPFIQQSIVTATLDHEGEQAIAAYYVLK-EPAAE 2644 Sbjct: 880 939 Query: 2645 KDIIRLLREQLPAYLIPRYWIELKFFPMTGPNKVDRNALPAPDAIPSNDLRHEYVPPRNE 2704 Sbjct: 940 ----- 994 Query: 2705 MENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNNLEKELKLTVEMGDLFKYPTI 2764 Sbjct: 995 1054 Query: 2765 SSLATFLKDKHN 2776 Sbjct: 1055 1066 Score = 61.6 bits (148), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 0/111 (0%), Positives = 0/111 (0%), Gaps = 13/111 (11%) Query: 1613 KNGPEPVTRKSQGKRPELPVAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGDSL 1672 Sbjct: 976 --------- 1026 Query: 1673 KAIHVISSIRKQFDCNLTLTDFFQNKTIKSVARFIRNASRANERQIAPVNP 1723 Sbjct: 1027 ---- 1073 >all2646 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1488 Score = 499 bits (1285), Expect = e-140, Method: Compositional matrix adjust. Identities = 269/630 (42%), Positives = 376/630 (59%), Gaps = 30/630 (4%) Query: 11 TGLEIAVIGLDCKFPQAADAGQFWNNLKHGVEGIQFFSDEEMIQSGIDPALCNDPNYVKA 70 TGLEIA+IG++ KFP A + ++W NL++GVE I +DE++ ++G+DP PNYVK Sbjct: 5 TGLEIAIIGINGKFPGANNLEEYWQNLRNGVESITNLTDEQIQKNGVDPTQLKHPNYVKR 64 Query: 71 RGILEDIEYFDASFFDYTPFEATVLDPQVRIFHECVMNALDNAGYNPDTYKGQIGLYAGS 130 + I+++IEYFDA FF + P EA +LDPQ R+F EC AL++AGYNP+ Y G IG+YAG+ Sbjct: 65 QAIIDNIEYFDAEFFGFNPREAEILDPQHRLFLECAWTALEDAGYNPENYTGAIGVYAGA 124 Query: 131 TEN-------ANWQLRQLLADEHPTFNMSFREYLCTSVSYKLRLRGPSVTVLSACSTSLV 183 N N Q++ ++ + F + +++L T VSYKL LRGPS+ + +ACSTSLV Sbjct: 125 AMNNYLLNLITNPQIQNQIS-RYQLFLSNDKDFLTTRVSYKLNLRGPSLDIQTACSTSLV 183 Query: 184 AVHLASQALLNGECNIALAGGGHLSLPSKKGYYYVEDLIYSADGHCRTFDAASQGTLISD 243 AVH+A Q+LL+GEC+IALAGG +SL GY Y E IYS DGHCR FDA +QGT+ Sbjct: 184 AVHVACQSLLSGECDIALAGG--VSLAKATGYLYQEGGIYSPDGHCRAFDADAQGTIAGS 241 Query: 244 GAGVVVLKTLQDAIQDRDHIYAVIKGSAVNNDGNRKAGFSAPSINGQREVIEAALQMAEV 303 G G+VVLK LQ+AI+DRD+I+AVIKGSA+NNDG K ++AP I+ Q VI AA +A V Sbjct: 242 GLGIVVLKRLQEAIEDRDYIHAVIKGSAINNDGGLKVSYTAPRIDTQAAVIRAAQALAGV 301 Query: 304 EAESITMVEAHGTGTKIGDSIEIEALKRAY--GTGHKAYCAIGSVKSNIGHLNEAAGIAG 361 E I+ +E HGTGT +GD IEI AL +A+ GT +CAI SVK+NIGHL+ AAGIA Sbjct: 302 EPADISYIETHGTGTALGDPIEIAALTQAFRAGTEKTGFCAISSVKTNIGHLDAAAGIAS 361 Query: 362 LIKTILSIEHRQXXXXXXXXXXXXXXEFEDTPFYVNNALADWTTAGTALRAAVSSFGIGG 421 LIKT+L+++H+Q +F TPFYVN L DW T T RA VSSFGIGG Sbjct: 362 LIKTVLALKHQQIPPNLHFQQPNPQIDFSQTPFYVNTNLVDWETDKTPRRAGVSSFGIGG 421 Query: 422 TNAHVILEEPPSLEPATEEKVP---RLFVFSAKTPTAVQEQISRFKQHLKSSPHLSLSDA 478 TNAHVILEE P K ++ SAK+ A++E +L+ P +L+D Sbjct: 422 TNAHVILEEAPIKFKIQNSKFKINYQMLCLSAKSEKALEEATINLATYLQQHPQFNLADI 481 Query: 479 AYTLQAGRRAMPNRAYIVASSHQELASKLEDKNVTVQSVDKSEYAVLYVLPDIDGNIQAV 538 AYTL GR+ R ++ + +E A LE + + + ++ ++ P + + Sbjct: 482 AYTLHIGRQHFAYRRMVLCQTTEEAAQILEKETKYTHTNSEKSPSIAFMFPGQGSHY--L 539 Query: 539 QQAISLYESHPVFRQAADTAMGKLGAHSGIDFRTLFLRGEKNQ-------------LQRE 585 LYE+ +FR+ D L G+D ++ E + + Sbjct: 540 NMGKELYETEAIFREQIDHCCELLQHDLGLDLLSILFETESIPSPQSPVPSPQSQTIYAQ 599 Query: 586 AIHFLFGYAVVSIMLQCNHKPLGLLGIKRG 615 F+ YA+ + + +P ++G G Sbjct: 600 PALFIIEYALAKLWISWGIQPQAMIGHSLG 629 Score = 173 bits (438), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 152/612 (24%), Positives = 259/612 (42%), Gaps = 67/612 (10%) Query: 642 AIADYPIHNPRVPMFSAASGGKLSLEELKEPDFWSNVRNSSFSLTTGMVNLVNTPKTLVA 701 A + P++P S +G ++ E+ +P +W N TG+ L+ P+ ++ Sbjct: 740 AFQKITLQTPKIPFISNVTGTWITAEQATDPHYWVNHLRQPVQFATGIKELLTEPQQILL 799 Query: 702 YIGT--EVHELMKAMDEPRSKLISFNPGADGISEDGCFQQWIGRLWSAGLGIRWEALEKA 759 +G + L K + L S D S+ Q +G+LW AG+ I WE Sbjct: 800 EVGAGRTLATLAKQQTNSHTILSSLRHPQDTQSDVAFLLQTLGQLWLAGVSIDWENFYTH 859 Query: 760 GNKGRIPLPAYPFERNRYFLDEDPAQLGQSLLQQVKGQTGQQKSAADCCYTATWKKAALS 819 + R+PLP YPF+R RY++D G+ G + + Y +W+++ Sbjct: 860 QQRQRLPLPTYPFQRQRYWIDLK------------AGEQGSENIPSPRLYLPSWERSLPH 907 Query: 820 SVKSRKGTKPSAIIVHD-VALDERTIEICSRYFDHPVFVAKACSPVTAGGATIQLENSSK 878 + ++ D + + I + V++ T + + Sbjct: 908 PQVDIAEKRLCWLVFTDNYGIYQEIINTLQAVGHDVIIVSQGEKYDQPAYRTFTVNPQNS 967 Query: 879 HAYCQMIQAYQKQTKAFPQNILYFALNDHGMESWDHGQEDLMLQETYYGLLSLVQAIDEC 938 + ++ + + + P +ILY WD LQ+ LL L QAI Sbjct: 968 QDFVELWSDLELR-ELIPHHILYL---------WDLTD----LQQQPLSLLYLAQAISSQ 1013 Query: 939 SANGMLQLNVVTNHLFDVLGNEEINPWNATLLGLIRGIPLEFPGLQCQLIEIA------D 992 S + L +VTN +LGNE I P AT+ G+ + I E P L C+ ++I+ Sbjct: 1014 SIEREITLTLVTNDGQLLLGNENIQPMKATVWGMGKVISQEIPQLTCRCVDISLSTVAST 1073 Query: 993 QEQLRLSAAADILFREAESSRDEIVAIRGNSKWLPMYEPLEPGPDTMPV-LSDQGVYLIT 1051 EQ+ A ++ + D +VA RGN +W +Y+PL + + + G Y+I Sbjct: 1074 NEQI----AQQLITECLNNQNDSVVAYRGNYRWNQIYKPLLMDDAQSKISVHEGGNYVIL 1129 Query: 1052 GG-SGGIGIELAEYLSRNCNASLVLLVRSAFPARSQWESWLREQAKHDPVSEKIRRIQAM 1110 G + G+G AE+L +N + LVLL D ++E ++ Q++ Sbjct: 1130 GDLTTGLGTVFAEFLMKN-SVRLVLL--------------------SDVITETLK--QSL 1166 Query: 1111 EQRGTQVYVYQSDVSDFNRLADTIQQVEQEIGRIQGVIHAAGLPGG---GFIQQQNKETA 1167 + G D++ L + I Q E + G+I GV ++ + F+ Q + Sbjct: 1167 DNVGIDYLSLNIDITKQAELENAIAQAETKFGQINGVFYSTPMSNEHSMAFLPQLTTKHW 1226 Query: 1168 DPVILTKALGCMHLNQILQDHPLDFFAVCSSVSTLFPIIGQSDYNAANAFVDAYAEYWNR 1227 + TK G L ++L+D PLDF + SS+ST+ +G + Y AANA +D +A N+ Sbjct: 1227 EYNYRTKIQGLCVLAEVLRDKPLDFCVLQSSLSTVLGGLGLAVYAAANAVIDMFAIQQNQ 1286 Query: 1228 FGKHRITSIKWD 1239 K SI WD Sbjct: 1287 NSKFPWISINWD 1298 Score = 66.2 bits (160), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 27/66 (40%), Positives = 45/66 (68%) Query: 2694 LRHEYVPPRNEMENMLARLWGEVLGIQHIGVDDGFFEIGGHSLLLMQVQNNLEKELKLTV 2753 L +EY+ PR+E+E +A++W ++LGI IG++D FF++GGHSLL +Q + L + + Sbjct: 1377 LTNEYIAPRDEIETAIAQIWQDLLGISPIGINDSFFDLGGHSLLAIQAISRLRDRFGVEL 1436 Query: 2754 EMGDLF 2759 M +L Sbjct: 1437 SMRNLL 1442 Score = 57.4 bits (137), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 26/69 (37%), Positives = 39/69 (56%) Query: 1627 RPELPVAYVPAGTDTEKKLCAIYENHLGFQPIGIEDDFFELSGDSLKAIHVISSIRKQFD 1686 RP+L Y+ + E + I+++ LG PIGI D FF+L G SL AI IS +R +F Sbjct: 1374 RPQLTNEYIAPRDEIETAIAQIWQDLLGISPIGINDSFFDLGGHSLLAIQAISRLRDRFG 1433 Query: 1687 CNLTLTDFF 1695 L++ + Sbjct: 1434 VELSMRNLL 1442 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.135 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 204,107,219 Number of extensions: 8758108 Number of successful extensions: 23191 Number of sequences better than 1.0e-05: 317 Number of HSP's gapped: 22228 Number of HSP's successfully gapped: 381 Length of query: 2806 Length of database: 38,378,431 Length adjustment: 124 Effective length of query: 2682 Effective length of database: 24,077,015 Effective search space: 64574554230 Effective search space used: 64574554230 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 125 (52.8 bits)