BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0489.0012.p (1728 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value all2635 [Q] COG3321 Polyketide synthase modules and related prot... 957 0.0 all2646 [Q] COG3321 Polyketide synthase modules and related prot... 940 0.0 AGl2329 [Q] COG3321 Polyketide synthase modules and related prot... 704 0.0 AGl2313 [Q] COG3321 Polyketide synthase modules and related prot... 694 0.0 all1649 [Q] COG3321 Polyketide synthase modules and related prot... 595 e-169 >all2635 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1565 Score = 957 bits (2473), Expect = 0.0, Method: Compositional matrix adjust. Identities = 571/1542 (37%), Positives = 848/1542 (54%), Gaps = 100/1542 (6%) Query: 11 EIAVIGLACRFPGADNREQFWNNLKDGLESVTVFTDEELRREGVTAEFLSNENYVKAGAV 70 E+A++G+A RFPGA N ++FW+NLK+G+ S+ ++E+L GV AE L +NYV+A A Sbjct: 38 EVAIVGMAGRFPGAKNVDEFWDNLKNGINSIKFLSNEDLLANGVKAEDLEKQNYVRAYAS 97 Query: 71 LDRFEYFDERFFGYSPKDALVMDPQVRLFHEVAWESLEDAGYVPDTYPGLIGVFAGASSN 130 L + FD FFGYSP++A ++DPQ RLF E AWE+LE+AGY + Y G I V+ GA+ N Sbjct: 98 LAGIDEFDAGFFGYSPREAEILDPQHRLFLECAWEALENAGYDSEQYSGNIAVYGGAALN 157 Query: 131 -YNWNARVYSYEGEHRDAFSEIQLSN-KDFLASRISYKFNLKGPSMXXXXXXXXXXXXIH 188 Y N S E+ D +++ +SN + +R+SYK NL G S +H Sbjct: 158 SYLVNLASNSNYRENSDR-TQVVISNVMGLMPTRVSYKLNLTGASCGIQTGCSTSLVSVH 216 Query: 189 TACRSLLSGECDMAIAGGSSILIPHRSGYLYQEGHFLSKDGHIRAFDEQASGILFGNGTG 248 AC+SLL+ ECD+A+AGG SI I ++GYLYQE LS DG+ RAFD A G +FGNG G Sbjct: 217 IACQSLLNKECDIALAGGVSIGIGEKAGYLYQEDGVLSPDGYCRAFDVNAKGTVFGNGVG 276 Query: 249 AVVLKPLENALADKDHIWAVVKGSAVNNDGNRKAGYMAPSVEGQREVIESALQVSEVGPD 308 VVLK L +A+ D DHI+A++K +A+NNDG++K G APSV GQ + I +AL +++ P+ Sbjct: 277 IVVLKRLRDAIQDGDHIYAIIKATAINNDGSQKVGLTAPSVTGQAKAITTALTKAKINPE 336 Query: 309 SISYIETHGTGTQLGDTIEFTALQQVF--HTRQSP-CILGSVKNNIGHLDAASGVAGFMK 365 +I YIETHGTGT LGD IE AL + F HT Q C +GSVK NIGHLDAA+G++G +K Sbjct: 337 TIQYIETHGTGTALGDPIEIAALTKAFSPHTHQKQFCAVGSVKTNIGHLDAAAGISGLIK 396 Query: 366 AVLALKHRQIPPMVNFAKSNPLLEMEKYPFAVNTKLLDWPLSSYPLRAGVSSFGVGGMNA 425 LALKH+QIPP +NF +NP ++ PF VNT+L W +P RAGVSSFG+GG NA Sbjct: 397 TALALKHKQIPPSLNFTAANPQIDFANSPFFVNTQLTPWINHQHPRRAGVSSFGMGGTNA 456 Query: 426 HLILEQAP--LPVEEPEEDLQPQLILLSAQSMESLENMTENLARHVEEHPDIRIRDVAYT 483 H ILE+AP ++ + + L+ LSA+S ++LE T NLA H+++HP++ + DVAYT Sbjct: 457 HAILEEAPTQFKIQNSKFKINYHLLCLSAKSEKALEQATINLATHLQKHPELNLADVAYT 516 Query: 484 LQAGRKPFEFRKQLICRDRKQLIEGLRKKDARQPQVNRVGEAPEQIVFMFPGQGAQYVNM 543 LQ GR+ F R+ L+C+ Q IE L DA Q IVFMFPGQG+QY+NM Sbjct: 517 LQIGRRAFNHRRCLVCQTPAQAIEILTGVDASQLLSYSPENTEPSIVFMFPGQGSQYLNM 576 Query: 544 GRELYHNEPIFRKYLDQCFAILQVHSETDYRAILFPSEEEAEQA---------------- 587 G+ELY+ EP+FRK +D C +LQ H D +ILF + E + Sbjct: 577 GQELYNTEPVFRKEIDHCSELLQPHLGCDLPSILFKQDNENSPSPQSPVPNLNYELRITN 636 Query: 588 REFMARLDHSLVILFIFGYALAELLMEWGIKPDVVIGYSLGEYIAGTVSGLFTLEQAIPL 647 E + + ++ LF YALA+L + +GI+P +IG+S+GEY+A T++G+FTL A+ + Sbjct: 637 YELLTQTTYAQPALFAVEYALAKLWLSYGIQPQAMIGHSIGEYVAATLAGVFTLADALAI 696 Query: 648 VLKRGRLFQQLPDGIMLSIPLPPDKVLPLLGDSLEIAIDNQVS-CVVGGPAHLVLELEEK 706 V +RG+L QQ P G+MLS+ L P+K+ P L D L IA+ N CVV G + LE+ Sbjct: 697 VAQRGKLMQQCPSGVMLSVSLAPEKLQPFLTDDLVIAVHNAPELCVVSGTEAAITLLEKL 756 Query: 707 LKQSKCVCTPLPTAKVIHTSRVESILDEYRAALQPVQYQPMKLRFMSSVTGDWAGPEELA 766 L L T+ H+ +E+ + LQ + P ++ F+S+VTG W PE+ Sbjct: 757 LTHQNITHRRLHTSHAFHSPLMETAVTPLTQILQNISLHPPQIPFISNVTGTWITPEQAT 816 Query: 767 TSQYWIDQLQEKVSFVKAVQRLADT-RTLFIEIGPGHDLSALVKRTFGQGPNVQVLNLIP 825 YW L++ V F + + L T +F+E+G G LS V R F P P Sbjct: 817 NPNYWATHLRQPVLFAEGITELQQTPNQIFVEVGFGQTLSTFV-RQFPDAPPTLSSGRHP 875 Query: 826 IGTSKVSEQHHLYDRIGKLWQYGYSADWNTF--SPQGRRIPLPTYAFMRKKFWLEEPSFP 883 T S+ + +G+LW G + +W+ Q RR+PLPTY F R+++W+E + P Sbjct: 876 QDTQ--SDVALICKTLGQLWLRGVTINWSELYTQQQRRRLPLPTYPFERQRYWVERDTLP 933 Query: 884 GRAGSQPYRMNRK-NIEEWYYVPSWKRLTPVTQAAPSQAKSERRRLIFGDHSSAGQKFTD 942 + + ++ I W+Y+PSW++ + AAP +++R L+F +AG++ Sbjct: 934 ETTSNTSKTLQKQEQISNWFYLPSWRQKPLLRSAAP---LNKQRYLVFCHAGNAGERLVQ 990 Query: 943 KWKTVSEGSVTVYKGEKRAKWSADELVINPARDEDYEWLFQELHAGSFIPDEMIHLWSLP 1002 + + VTV GE + D I P EDY+ L+ +L +PD +IH W+L Sbjct: 991 HLQETGQEVVTVKPGEGFTQ-EGDNYAIAPHNPEDYKTLWLQLQTDDKLPDVIIHSWTLQ 1049 Query: 1003 ----FDQKEAHALVPDAGLDDGYFSLLAIAKACGQHLGEHPLELRVITNGVCEVMGDDAT 1058 F Q++ + G++SLL + +A L L + V+T V V+G++ Sbjct: 1050 ERTNFQQQQ----------NLGFYSLLWLTQA----LSSSSLSIYVLTQQVQNVLGNENL 1095 Query: 1059 SPHKATMLGPVKVIPLEYPSIRCSLLDMEL----LPDGSRLDNMIDSLVSQLAAAK--WE 1112 +P AT+LG VKVIP EYP++ C +D+ + R N+ L L K Sbjct: 1096 NPDDATILGLVKVIPQEYPNLTCQHIDVSISDINFQQLVREINIPPVLSDTLPLEKGGLR 1155 Query: 1113 SVAAYRNNSFWVPTCNAVTLDTRHAMKIQPHGKYLIT-XXXXXXXXXXXXXXXRQARVEL 1171 AYR + W+ ++L + + G Y+I +L Sbjct: 1156 MSVAYRGKTRWIQEFQPISLPEPTQLPLITGGVYVIAGDLVEGLGLIYAKFLAATVNAKL 1215 Query: 1172 ILAGRTPFPPKEEWAEWSAPH-----LAEEIQKLTEIENSGGTVHVLQADISNPAEVQAL 1226 + GR+ P +EW W A H ++ IQ+L ++ G D++ ++V+ Sbjct: 1216 VFLGRSDLPQPKEWDNWLATHGRQDAVSHCIQQLQGLQAQGCEFLFTTVDLAEISQVEDA 1275 Query: 1227 LTQVEHTVGELTGVIHAAGVAD--GELIQRSTRESSKNMLAAKVDGTLCLYEALRGKPLD 1284 + Q G++ GVIHA + D LI+ T + K+ G L L AL+ +PLD Sbjct: 1276 IAQALTRFGKINGVIHAGVMGDRASCLIRNLTIPECEKQFHTKIHGLLALETALKNQPLD 1335 Query: 1285 FFILCSSLSSYLPAIGQAGYCAANAFLDSFAFYAHAQNPGFPVLSVNWERWKQTGMSRRI 1344 FF+L SSLS+ + IG A Y AN F+D+ A + QN +S+NW+ ++ Sbjct: 1336 FFLLQSSLSAVVGGIGFAAYAGANCFMDAIA-HQRTQNSNTHWISINWDAVSLAEITTS- 1393 Query: 1345 EALHKELTGSELED-TITEGEGIQIFSRIGNLAVP---QIIISAFDMNERVQLYELAGSP 1400 TG+ L D +T E Q+ RI LA P QI +S D+ R Q P Sbjct: 1394 -------TGATLIDLAMTSQEVWQVTERI--LAQPIAAQITVSPVDLASRQQ-----SQP 1439 Query: 1401 LDFEGAESISHQQPVAGIFERPSLTTEYVPPRNERERELAQLWEAQFGVQPVGMDDSLFE 1460 L+ + +H RP +T Y+PP NE E + Q+ E+ G+ P+G++D+ FE Sbjct: 1440 LE---QSTTNH--------ARPQITATYLPPSNEIEARVTQVMESLLGIAPIGVNDNFFE 1488 Query: 1461 LGGDSLMALSILARVQKQWNERIPMAYFI-NHPTVAGISSYM 1501 LGG SL+A+ ++++++++ +PM F+ PT+ GI+ + Sbjct: 1489 LGGHSLLAIQAVSQLREEFQVELPMRQFLFESPTIGGIAKII 1530 >all2646 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1488 Score = 940 bits (2429), Expect = 0.0, Method: Compositional matrix adjust. Identities = 546/1507 (36%), Positives = 840/1507 (55%), Gaps = 91/1507 (6%) Query: 1 MADPSDYNGLEIAVIGLACRFPGADNREQFWNNLKDGLESVTVFTDEELRREGVTAEFLS 60 M +P+ GLEIA+IG+ +FPGA+N E++W NL++G+ES+T TDE++++ GV L Sbjct: 1 MNNPT---GLEIAIIGINGKFPGANNLEEYWQNLRNGVESITNLTDEQIQKNGVDPTQLK 57 Query: 61 NENYVKAGAVLDRFEYFDERFFGYSPKDALVMDPQVRLFHEVAWESLEDAGYVPDTYPGL 120 + NYVK A++D EYFD FFG++P++A ++DPQ RLF E AW +LEDAGY P+ Y G Sbjct: 58 HPNYVKRQAIIDNIEYFDAEFFGFNPREAEILDPQHRLFLECAWTALEDAGYNPENYTGA 117 Query: 121 IGVFAGASSNYNWNARVYSYEGEHRDAFSEIQLSN-KDFLASRISYKFNLKGPSMXXXXX 179 IGV+AGA+ N + + + +++ + ++ LSN KDFL +R+SYK NL+GPS+ Sbjct: 118 IGVYAGAAMNNYLLNLITNPQIQNQISRYQLFLSNDKDFLTTRVSYKLNLRGPSLDIQTA 177 Query: 180 XXXXXXXIHTACRSLLSGECDMAIAGGSSILIPHRSGYLYQEGHFLSKDGHIRAFDEQAS 239 +H AC+SLLSGECD+A+AGG S + +GYLYQEG S DGH RAFD A Sbjct: 178 CSTSLVAVHVACQSLLSGECDIALAGGVS--LAKATGYLYQEGGIYSPDGHCRAFDADAQ 235 Query: 240 GILFGNGTGAVVLKPLENALADKDHIWAVVKGSAVNNDGNRKAGYMAPSVEGQREVIESA 299 G + G+G G VVLK L+ A+ D+D+I AV+KGSA+NNDG K Y AP ++ Q VI +A Sbjct: 236 GTIAGSGLGIVVLKRLQEAIEDRDYIHAVIKGSAINNDGGLKVSYTAPRIDTQAAVIRAA 295 Query: 300 LQVSEVGPDSISYIETHGTGTQLGDTIEFTALQQVFHT---RQSPCILGSVKNNIGHLDA 356 ++ V P ISYIETHGTGT LGD IE AL Q F + C + SVK NIGHLDA Sbjct: 296 QALAGVEPADISYIETHGTGTALGDPIEIAALTQAFRAGTEKTGFCAISSVKTNIGHLDA 355 Query: 357 ASGVAGFMKAVLALKHRQIPPMVNFAKSNPLLEMEKYPFAVNTKLLDWPLSSYPLRAGVS 416 A+G+A +K VLALKH+QIPP ++F + NP ++ + PF VNT L+DW P RAGVS Sbjct: 356 AAGIASLIKTVLALKHQQIPPNLHFQQPNPQIDFSQTPFYVNTNLVDWETDKTPRRAGVS 415 Query: 417 SFGVGGMNAHLILEQAPL--PVEEPEEDLQPQLILLSAQSMESLENMTENLARHVEEHPD 474 SFG+GG NAH+ILE+AP+ ++ + + Q++ LSA+S ++LE T NLA ++++HP Sbjct: 416 SFGIGGTNAHVILEEAPIKFKIQNSKFKINYQMLCLSAKSEKALEEATINLATYLQQHPQ 475 Query: 475 IRIRDVAYTLQAGRKPFEFRKQLICRDRKQLIEGLRKKDARQPQVNRVGEAPEQIVFMFP 534 + D+AYTL GR+ F +R+ ++C+ ++ + L +K+ + N E I FMFP Sbjct: 476 FNLADIAYTLHIGRQHFAYRRMVLCQTTEEAAQIL-EKETKYTHTN--SEKSPSIAFMFP 532 Query: 535 GQGAQYVNMGRELYHNEPIFRKYLDQCFAILQVHSETDYRAILFPSEEEAEQAREFMARL 594 GQG+ Y+NMG+ELY E IFR+ +D C +LQ D +ILF +E + Sbjct: 533 GQGSHYLNMGKELYETEAIFREQIDHCCELLQHDLGLDLLSILFETESIPSPQSPVPSPQ 592 Query: 595 DHSLV---ILFIFGYALAELLMEWGIKPDVVIGYSLGEYIAGTVSGLFTLEQAIPLVLKR 651 ++ LFI YALA+L + WGI+P +IG+SLGEY+ T++G+F+L + LV R Sbjct: 593 SQTIYAQPALFIIEYALAKLWISWGIQPQAMIGHSLGEYVVATLAGVFSLPDVLKLVALR 652 Query: 652 GRLFQQLPDGIMLSIPLPPDKVLPLLGDSLEIAIDNQVS-CVVGGPAHLVLELEEKLKQS 710 GRL QQ P G MLS+ + K+ PLL D+L IA N CVV G +++LE L + Sbjct: 653 GRLMQQCPTGAMLSVGMSAAKLQPLLTDNLVIAAYNAPELCVVSGTEAEIVQLETNLNKQ 712 Query: 711 KCVCTPLPTAKVIHTSRVESILDEYRAALQPVQYQPMKLRFMSSVTGDWAGPEELATSQY 770 L T+ H+ +ES++ + AA Q + Q K+ F+S+VTG W E+ Y Sbjct: 713 GISNRRLQTSHAFHSPLMESMITPFIAAFQKITLQTPKIPFISNVTGTWITAEQATDPHY 772 Query: 771 WIDQLQEKVSFVKAVQR-LADTRTLFIEIGPGHDLSALVKRTFGQGPNVQVLNLIPIGTS 829 W++ L++ V F ++ L + + + +E+G G L+ L K+ Q + +L+ + Sbjct: 773 WVNHLRQPVQFATGIKELLTEPQQILLEVGAGRTLATLAKQ---QTNSHTILSSLRHPQD 829 Query: 830 KVSEQHHLYDRIGKLWQYGYSADWNTF--SPQGRRIPLPTYAFMRKKFWLEEPSFPGRAG 887 S+ L +G+LW G S DW F Q +R+PLPTY F R+++W++ + G G Sbjct: 830 TQSDVAFLLQTLGQLWLAGVSIDWENFYTHQQRQRLPLPTYPFQRQRYWIDLKA--GEQG 887 Query: 888 SQPYRMNRKNIEEWYYVPSWKRLTPVTQAAPSQAKSERRR--LIFGDHSSAGQKFTDKWK 945 S+ R Y+PSW+R P P +E+R L+F D+ Q+ + + Sbjct: 888 SENIPSPR------LYLPSWERSLP----HPQVDIAEKRLCWLVFTDNYGIYQEIINTLQ 937 Query: 946 TVSEGSVTVYKGEKRAKWSADELVINPARDEDYEWLFQELHAGSFIPDEMIHLWSLPFDQ 1005 V + V +GEK + + +NP +D+ L+ +L IP +++LW L Q Sbjct: 938 AVGHDVIIVSQGEKYDQPAYRTFTVNPQNSQDFVELWSDLELRELIPHHILYLWDLTDLQ 997 Query: 1006 KEAHALVPDAGLDDGYFSLLAIAKACGQHLGEHPLELRVITNGVCEVMGDDATSPHKATM 1065 ++ SLL +A+A E + L ++TN ++G++ P KAT+ Sbjct: 998 QQP-------------LSLLYLAQAISSQSIEREITLTLVTNDGQLLLGNENIQPMKATV 1044 Query: 1066 LGPVKVIPLEYPSIRCSLLDMELLPDGSRLDNMIDSLVSQLAAAKWESVAAYRNNSFWVP 1125 G KVI E P + C +D+ L S + + L+++ + +SV AYR N W Sbjct: 1045 WGMGKVISQEIPQLTCRCVDISLSTVASTNEQIAQQLITECLNNQNDSVVAYRGNYRWNQ 1104 Query: 1126 TCNAVTLDTRHAMKIQPH--GKYLITXXXXXXXXXXXXXXXRQARVELILAGRTPFPPKE 1183 + +D + KI H G Y+I + V L+L Sbjct: 1105 IYKPLLMDDAQS-KISVHEGGNYVILGDLTTGLGTVFAEFLMKNSVRLVLLSDV------ 1157 Query: 1184 EWAEWSAPHLAEEIQKLTEIENSGGTVHVLQADISNPAEVQALLTQVEHTVGELTGVIHA 1243 + E +++ ++N G L DI+ AE++ + Q E G++ GV ++ Sbjct: 1158 ---------ITETLKQ--SLDNVGIDYLSLNIDITKQAELENAIAQAETKFGQINGVFYS 1206 Query: 1244 AGVADGE----LIQRSTRESSKNMLAAKVDGTLCLYEALRGKPLDFFILCSSLSSYLPAI 1299 +++ L Q +T+ N K+ G L E LR KPLDF +L SSLS+ L + Sbjct: 1207 TPMSNEHSMAFLPQLTTKHWEYNY-RTKIQGLCVLAEVLRDKPLDFCVLQSSLSTVLGGL 1265 Query: 1300 GQAGYCAANAFLDSFAFYAHAQNPGFPVLSVNWERWKQTGMSRRIEALHKELTGSELEDT 1359 G A Y AANA +D FA + QN FP +S+NW+ + S ++ + + Sbjct: 1266 GLAVYAAANAVIDMFAIQQN-QNSKFPWISINWDACR----SDLETDINHSFAANLVTLA 1320 Query: 1360 ITEGEGIQIFSRIGNLAVPQ-IIISAFDMNERVQLYELAGSPLDFEGAESISHQQPVAGI 1418 +T E Q I L +P+ ++++ D+++R++ + + +P + + S Sbjct: 1321 LTPAEVWQSTQHIIKLGLPESVVVTKSDLDKRLEKW-VTNTPTKTKTETNNS-------- 1371 Query: 1419 FERPSLTTEYVPPRNERERELAQLWEAQFGVQPVGMDDSLFELGGDSLMALSILARVQKQ 1478 + RP LT EY+ PR+E E +AQ+W+ G+ P+G++DS F+LGG SL+A+ ++R++ + Sbjct: 1372 YTRPQLTNEYIAPRDEIETAIAQIWQDLLGISPIGINDSFFDLGGHSLLAIQAISRLRDR 1431 Query: 1479 WNERIPM 1485 + + M Sbjct: 1432 FGVELSM 1438 >AGl2329 [Q] COG3321 Polyketide synthase modules and related proteins Length = 211 Score = 704 bits (1817), Expect = 0.0, Method: Compositional matrix adjust. Identities = 0/1524 (0%), Positives = 0/1524 (0%), Gaps = 98/1524 (6%) Query: 12 IAVIGLACRFPGADNREQFWNNLKDGLESVTVFTDEELRREGVTAEFLSNENYVKAGAVL 71 ++ A V ++ + + Sbjct: 40 AQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENIIKTCRILLEQ 99 Query: 72 DRFEYFDERFFGYSPKDALVMDPQVRLFHEVAWESLEDAGYVPDTYPGLIGVFAGASSNY 131 E ++R + V L W ++ ++ Sbjct: 100 HNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQV 159 Query: 132 NWNARVYSYEGEHRDAFSEIQ--LSN-KDFLASRISYKFNLKGPSMXXXXXXXXXXXXIH 188 + L Sbjct: 160 EEK-LLKV-VPAEFKVDCHHWLILHGR 217 Query: 189 TACRSLLSGECDMAIAGGSSILIPHRSGYLYQEGHFLSKDGHIRAFDEQASGILFGNGTG 248 Sbjct: 218 277 Query: 249 AVVLKPLENALADKDHIWAVVKGSAVNNDGNRKAGYMAPSVEGQREVIESALQVSEVGPD 308 Sbjct: 278 337 Query: 309 SISYIETHGTGTQLGDTIEFTALQQVF----HTRQSPCILGSVKNNIGHLDAASGVAGFM 364 Sbjct: 338 397 Query: 365 KAVLALKHRQIPPMVNFAKSNPLLEMEKYPFAVNTKLLDWPL-SSYPLRAGVSSFGVGGM 423 Sbjct: 398 457 Query: 424 NAHLILEQAPLPVEEPEED----LQPQLILLSAQSMESLENMTENLARHVEEHPDIRIRD 479 Sbjct: 458 - 516 Query: 480 VAYTLQAGRKPFEFRKQLICRDRKQLIEGLRKKDARQPQVNRVGEAPEQIVFMFPGQGAQ 539 Sbjct: 517 576 Query: 540 YVNMGRELYHNEPIFRKYLDQCFAILQVHSETDYRAILFPSEEEAEQAREFMARLDHSLV 599 Sbjct: 577 ----- 631 Query: 600 ILFIFGYALAELLMEWGIKPDVVIGYSLGEYIAGTVSGLFTLEQAIPLVLKRGRLFQQLP 659 Sbjct: 632 691 Query: 660 DGIMLSIPLPPDKVLPLLGDSLEI-AIDNQVSCVVGGPAHLVLELEEKLKQSKCVCTPLP 718 Sbjct: 692 751 Query: 719 TAKVIHTSRVESILDEYRAALQPVQYQPMKLRFMSSVTGDWAGPEELATSQYWIDQLQEK 778 Sbjct: 752 811 Query: 779 VSFVKAVQR-LADTRTLFIEIGPGHDLSALVKRTFGQGPNVQVLNLIPIGTSKVSEQHHL 837 Sbjct: 812 -- 869 Query: 838 YDRIGKLWQYGYSADWNTF---SPQGRRIPLPTYAFMRKKFWLEEPSFPGRAGSQPYRMN 894 Sbjct: 870 ---- 925 Query: 895 RKNIEEWYYVPSWKRLTPVTQAAPSQAKSERRRLIFGDHSSAGQKFTDKWKTVSEGSVTV 954 Sbjct: 926 ---------- 975 Query: 955 YKGEKRAKWSADE--LVINPARDEDYEWLFQELHAGSFIPDEMIHLWSLPFDQKEAHALV 1012 Sbjct: 976 --------- 1026 Query: 1013 PDAGLDDGYFSLLAIAKACGQHLGEHPLELRVITNGVCEVMGDDATSPHKATMLGPVKVI 1072 Sbjct: 1027 ------ 1080 Query: 1073 PLEYPSIRCSLLDMELLPDGSR---LDNMIDSLVSQLAAAKWESVAAYRNNSFWVPTCNA 1129 Sbjct: 1081 ----- 1135 Query: 1130 VTLDTRHAMKIQPHGK-YLITXXXXXXXXXXXXXXXRQARVELILAGRTPFPPKEEWAEW 1188 Sbjct: 1136 1195 Query: 1189 SAPHLAEE-----IQKLTEIENSGGTVHVLQADISNPAEVQALLTQVEHTVGELTGVIHA 1243 Sbjct: 1196 1255 Query: 1244 AGVADGELIQRSTRESSKNMLAAKVDGTLCLYEALRGKPLDFFILC-SSLSSYLPAIGQA 1302 Sbjct: 1256 1315 Query: 1303 GYCAANAFLDSFAFYAHAQNPGFPVL-SVNWERWKQTGMSRRIEALHKELTGSELEDTIT 1361 Sbjct: 1316 ------- 1368 Query: 1362 EGEGIQIFSRIGNLAVP-QIIISAFDMNERVQLYELAGSPLDFEGAESISHQQPVAGIFE 1420 Sbjct: 1369 --------------- 1413 Query: 1421 RPSLTTEYVPPRNERERELAQLWEAQFGVQPVGMDDSLFELGGDSLMALSILARVQKQWN 1480 Sbjct: 1414 1473 Query: 1481 ERIPM-AYFINHPTVAGISSYMEQ 1503 Sbjct: 1474 1497 >AGl2313 [Q] COG3321 Polyketide synthase modules and related proteins Length = 211 Score = 694 bits (1791), Expect = 0.0, Method: Compositional matrix adjust. Identities = 0/1539 (0%), Positives = 0/1539 (0%), Gaps = 145/1539 (9%) Query: 2 ADPSDYNGLEIAVIGLACRFPGADNREQFWNNLKDGLESVTVFTDEELRREGVTAEFLSN 61 ++ N + +A ++ Sbjct: 19 HPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKT 78 Query: 62 ENYVKAGAVLDRFEYFDERFFGYSPKDALVMDPQVRLFHEVAWESLEDAGYVPDTYPGLI 121 + A + ++ + Sbjct: 79 IGLYNSKAENIIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVD 138 Query: 122 GVFAGASSNYNWNARVYSYEGEHRDAFSEIQL---SNKDFLASRISYKFNLKGPSMXXXX 178 + + ++ + ++ Sbjct: 139 THIF--RVCNRTQFAPGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGS 196 Query: 179 XXXXXXXXIHTACRSLLSGECDMAIAGGSSILIPHRSGYLYQEGHFLSKDGHIRAFDEQA 238 Sbjct: 197 -- 254 Query: 239 SGILFGNGTGAVVLKPLENALADKDHIWAVVKGSAVNNDGNRKAGYMAPSVEGQREVIES 298 Sbjct: 255 314 Query: 299 ALQVSEVGPDSISYIETHGTGTQLGDTIEFTALQQVFHT---RQSPCILGSVKNNIGHLD 355 Sbjct: 315 374 Query: 356 AASGVAGFMKAVLALKHRQIPPMVNFAKSNPLLEMEKYPFAVNTKLLDWPLSSYPLRAGV 415 Sbjct: 375 434 Query: 416 SSFGVGGMNAHLILEQAPLPVE--EPEEDLQPQLILLSAQSMESLENMTENLARHVEEHP 473 Sbjct: 435 494 Query: 474 DIRIRDVAYTLQAGRKPFEFRKQLICRDRKQLIEGLRKKDARQPQVNRVGEAPEQIVFMF 533 Sbjct: 495 --- 551 Query: 534 PGQGAQYVNMGRELYHNEPIFRKYLDQCFAILQVHSETDYRAILFPSEEEAEQAREFMAR 593 Sbjct: 552 ---- 607 Query: 594 LDHSLVILFIFGYALAELLMEWGIKPDVVIGYSLGEYIAGTVSGLFTLEQAIPLVLKRGR 653 Sbjct: 608 --- 664 Query: 654 LFQQLPDGIMLSIPLPPDKVLPLLGDSLEIAIDNQVS-CVVGGPAHLVLELEEKLKQSKC 712 Sbjct: 665 724 Query: 713 VCTPLPTAKVIHTSRVESILDEYRAALQPVQYQPMKLRFMSSVTGDWAGPEELATSQYWI 772 Sbjct: 725 784 Query: 773 DQLQEKVSFVKAVQRL-ADTRTLFIEIGPGHDLSALVKRTFGQGPNVQVLNLIP-IGTSK 830 Sbjct: 785 ----- 839 Query: 831 VSEQHHLY-DRIGKLWQYGYSADWNTFSPQGRRIPLPTYAFMRKKFWLEEPSFPGRAG-S 888 Sbjct: 840 899 Query: 889 QPYRMNRKNIEEWYYVPSWKRLTPVTQAAPSQAKSERRRLIFGDHSSAGQKFTDKWKTVS 948 Sbjct: 900 ----------- 948 Query: 949 EGSVTVYKGEKRAKWSADELVINPARDEDYEWLFQELHAGSFIPDEMIHLWSL-PFDQKE 1007 Sbjct: 949 1008 Query: 1008 AHALVPDAGLDDGYFSLLAIAKACGQHLGEHPLELRVITNGVCEVMGDDATSPHKATMLG 1067 Sbjct: 1009 --------------- 1053 Query: 1068 PVKVIPLEYPSIRCSLLDMELLPDGSRLDNMIDSLVSQLAAAKWE---SVAAYRNNSFWV 1124 Sbjct: 1054 ------ 1107 Query: 1125 PTCNAVTL-DTRHAMKIQPHGKYLITXXXXXXXXXXXXXXXRQARVELILAGRTPFPPKE 1183 Sbjct: 1108 ------------------------- 1142 Query: 1184 EWAEWSAPHLAEEIQKLTEIEN------SGGTVHVLQADISNPAEVQALLTQVEHTVGEL 1237 Sbjct: 1143 1202 Query: 1238 TGVI----HAAGVADGELIQRSTRESSKNMLAAKVDGTLCLYEALRGKPLDFFILCSSLS 1293 Sbjct: 1203 - 1261 Query: 1294 SYLPAIGQAGYCAANAFLDSF--AFYAHAQNP----GFPVLSVNWERWKQTGMSRRIEAL 1347 Sbjct: 1262 - 1320 Query: 1348 HK----ELTGSELEDTITEGEGIQIFSRIGNLAVPQIIISAFDMNERVQLYELAGSPLDF 1403 Sbjct: 1321 ----------------- 1363 Query: 1404 EGAESISHQQPVAGIFERPSLTTEYVPPRNERERELAQLWEAQFGVQPVGMDDSLFELGG 1463 Sbjct: 1364 ----------- 1412 Query: 1464 DSLMALSILARVQKQWNERIPMAYFI-NHPTVAGISSYM 1501 Sbjct: 1413 1451 >all1649 [Q] COG3321 Polyketide synthase modules and related proteins Length = 1570 Score = 595 bits (1533), Expect = e-169, Method: Compositional matrix adjust. Identities = 461/1580 (29%), Positives = 736/1580 (46%), Gaps = 159/1580 (10%) Query: 12 IAVIGLACRFPGADNREQFWNNLKDGLESVTVF------TDEELRREGVTAEFLSNENYV 65 IA+IG+ CRFPGAD+ + FW L +G++++T DE R T + N Y Sbjct: 4 IAIIGIGCRFPGADSPQAFWQLLSNGVDAITEIPAERWNIDEFYDRNPETPGKM-NARY- 61 Query: 66 KAGAVLDRFEYFDERFFGYSPKDALVMDPQVRLFHEVAWESLEDAGYVPDTYPG-LIGVF 124 G L + + FD FFG SP++AL+MDPQ RL EVAWE+LEDAG V + G GVF Sbjct: 62 --GGFLSQVDRFDPHFFGISPREALLMDPQQRLLLEVAWEALEDAGIVREQLTGSKTGVF 119 Query: 125 AGASSN--------YNWNARVYSYEGEHRDAFSEIQLSNKDFLASRISYKFNLKGPSMXX 176 G S+N ++ N + Y G + + A R+SY FNL+GPS+ Sbjct: 120 VGISTNDYSRIHPEFDSNPQGYDLTG-----------NCINIAAGRLSYLFNLRGPSLAV 168 Query: 177 XXXXXXXXXXIHTACRSLLSGECDMAIAGGSSILIPHRSGYLYQEGHFLSKDGHIRAFDE 236 +H AC+S+ + E MAIA G ++++ + LS DG + FDE Sbjct: 169 DTACSSSLVAVHLACQSIWNQESSMAIASGVNLVLSPIGNIALSKLKALSPDGRCKTFDE 228 Query: 237 QASGILFGNGTGAVVLKPLENALADKDHIWAVVKGSAVNNDGNRKAGYMAPSVEGQREVI 296 A+G + G G ++LKP+ ALAD D I+AV++GSA+N+DG R G P Q +I Sbjct: 229 SANGYVRSEGAGCIILKPIAQALADHDPIYAVIRGSAINHDG-RSKGLTVPYGPAQESLI 287 Query: 297 ESALQVSEVGPDSISYIETHGTGTQLGDTIEFTALQQVF---HTRQSPCILGSVKNNIGH 353 ALQ ++V P ISY+E HGTGT LGD IE A+ V PC++G+VK+NIGH Sbjct: 288 RQALQQAQVQPKEISYVELHGTGTPLGDPIEAMAIGAVLGEGRDAAHPCLVGAVKSNIGH 347 Query: 354 LDAASGVAGFMKAVLALKHRQIPPMVNFAKSNPLLEMEKYPFAVNTKLLDWPLSSYPLRA 413 L+AA+G+A +K LALK++QIPP ++F + NP + ++ P V T L+ WP S Y +A Sbjct: 348 LEAAAGIASIIKMALALKYQQIPPSLHFHQPNPYIPFDQLPLRVQTSLIPWPKSKYGAKA 407 Query: 414 GVSSFGVGGMNAHLILEQAPLPVEEPEEDLQ--PQLILLSAQSMESLENMT---ENLARH 468 GVSSFG G NAH+ILE PE+ P L+ LSA + +++ + ++L Sbjct: 408 GVSSFGFSGTNAHVILEGVS-SFNSPEQQTCKFPHLLPLSAHTPAAVQTLALGYQDLINA 466 Query: 469 VEEHPDIRIRDVAYTLQAGRKPFEFRKQLICR---DRKQLIEGLRKKDARQPQVNRVGEA 525 + P+ ++++ Y+ R +R ++ D ++ L D Q + Sbjct: 467 QKLTPEF-VQNLCYSASVRRTHQSYRSAVVVNSPEDLPSCLQALATADITT-QTKQSKRK 524 Query: 526 PEQIVFMFPGQGAQYVNMGRELYHNEPIFRKYLDQCFAILQVHSETDYRAILFPSEEEAE 585 P ++ F+F GQG Q+ MGREL EP+FR +++C A++Q +++ +E Sbjct: 525 P-KVAFVFSGQGPQWWAMGRELLAQEPVFRAVIEECDALIQKYAQWS-----LLTEFAVP 578 Query: 586 QAREFMARLDHSLVILFIFGYALAELLMEWGIKPDVVIGYSLGEYIAGTVSGLFTLEQAI 645 +++ + + LF LA L WGI+P V+G+SLGE A ++G+ +LE A+ Sbjct: 579 ESQSRFQETEIAQPALFALQVGLAHLWRSWGIEPKAVVGHSLGEVAAAHIAGVLSLEDAV 638 Query: 646 PLVLKRGRLFQQLP-DGIMLSIPLPPDKVLPLL---GDSLEI-AIDNQVSCVVGGPAHLV 700 L+ RGRL QQ +G ML++ LP +V PLL LEI AI++ + V+ G + + Sbjct: 639 HLICHRGRLMQQATGNGKMLAVELPATEVEPLLTAWAGQLEIAAINSPTATVISGQSQAL 698 Query: 701 LELEEKLKQS--KCVCTPLPTAKVIHTSRVESILDEYRAALQPVQYQPMKLRFMSSVTGD 758 +L+Q LP H+ ++ + L +Q Q L S+VTGD Sbjct: 699 QIFVTQLQQQHPDIFYKELPVNYAFHSQQMAPFAEALVEKLSHIQPQAGSLAVFSTVTGD 758 Query: 759 WAGPEELATSQYWIDQLQEKVSFVKAVQRLADT-RTLFIEIGPGHDLSALVKRTFGQGPN 817 E+ + YW L+ V F A+ L + T F+EI P LS + + Sbjct: 759 KQAGEKF-NADYWGQNLRHTVCFAPALTALIQSGYTQFVEISPHPVLSGYINACLRKQEV 817 Query: 818 VQVLNLIPIGTSKVSEQHHLYDRIGKLWQYGYSADWNTFSPQG-RRIPLPTYAFMRKKFW 876 V ++P E+ L +G L+ G+S +W + P G + + LP Y + R+ +W Sbjct: 818 DGV--ILPSLKRGFGERATLLKSLGTLYTLGHSINWQSLYPDGCQMVDLPLYPWQRESYW 875 Query: 877 LEE--PSF----PGRA------GSQPYRMNRKNIEEWYYVPSWKRLTP------------ 912 + E P F P + + ++ ++ P K+ P Sbjct: 876 VSESQPQFQKALPASSLLNLLVAGKTEQLTQELSNHHQLSPEAKQFIPQLLQLLATGKST 935 Query: 913 --VTQ----------------AAPSQAKSERRRLIFGDHSSAGQKFTDKWKTVSEGSVTV 954 +TQ ++ R LIF D+ GQ+ V++ + V Sbjct: 936 AKITQDLSNARYRIEWQLSPLTVDNKTSEAERWLIFSDNQGLGQELA---AVVNDSCILV 992 Query: 955 YKGEKRAKWSADELVINPARDEDYEWLFQELHAGSFIPDEMIHLWSLPFDQKEAHALVPD 1014 GE K S+ INP + D++ L ++ S ++++LWSL ++ + Sbjct: 993 SSGESYEKLSSSHYQINPHQAADFQQLLADI---SEPITKVVYLWSLD------SSINLE 1043 Query: 1015 AGLDDGYFSLLAIAKACGQHLGEHPLELRVITNGVCEVMGD-DATSPHKATMLGPVKVIP 1073 Y LL + +A + + +L + T V + + + G +VI Sbjct: 1044 NSQPQCYSHLLYLVQALAKISSKIAPQLWIGTQQAQAVTPSCHQINVAQTPLWGMGQVIA 1103 Query: 1074 LEYPSIRCSLLDMELLPDGSRLDNMIDSLVSQLAAAKWESVAAYRNNSFWVPTCNAVTLD 1133 LEYP + L+D D ++++++ A E A+R+ +V ++ Sbjct: 1104 LEYPQLWGGLIDF------GNQDVAATAIIAEMTAKTGEDRVAFRDGKRYVARLMPISAP 1157 Query: 1134 TRHAMKIQPHGKYLITXXXXXXXXXXXXXXXRQARVELILAGRTPFPPKEEWAEWSAPHL 1193 + G YLIT +Q L+L R + E Sbjct: 1158 LPAPQPLISDGSYLITGGLGALGLTLAEWLVQQGARHLVLTSRQGLLNQSE--------- 1208 Query: 1194 AEEIQKLTEIENSGGTVHVLQADISNPAEVQALLTQVEHTVGELTGVIHAAGVADGELIQ 1253 E+ QK+ +EN G TV V+ AD+S+ ++ L Q++ +L G+IHAAGV + I Sbjct: 1209 -EKQQKIRALENQGATVKVVAADVSDYQQMSQLFAQIQLNSPKLRGIIHAAGVLNDCSIA 1267 Query: 1254 RSTRESSKNMLAAKVDGTLCLYEALRGKPLDFFILCSSLSSYLPAIGQAGYCAANAFLDS 1313 + E+ + KV G L++ + LDFF+ SS+S+ L + GQ Y AAN+FLD Sbjct: 1268 QMDSETFTKVFQPKVTGAWNLHQLTQDLSLDFFVCFSSMSALLGSRGQLHYAAANSFLDG 1327 Query: 1314 FAFYAHAQNPGFPVLSVNWERWKQTGMSRR-IEALHKELTGSELEDTITEGEGIQIFSRI 1372 + H Q+ G P LS+NW W + GM+ + E K + LE T +Q+ + Sbjct: 1328 LVY--HRQSLGLPGLSINWGPWAEGGMATQGYEVGLKRMGIEPLEPT----AALQVLGGL 1381 Query: 1373 GNLAVPQIIISAFDMNE---------RVQLYE--LAGSPLDFEGAESISHQQPVAGIFER 1421 A Q +++A + + RV E L D E+ + A + R Sbjct: 1382 LGSASMQTMVAAINWSAFGKIVAAKGRVAFLEALLTQESKDGSNGENFRQKLSAAPLHRR 1441 Query: 1422 PSLTTEYVPPRNERERELAQLWEAQFGVQPVGMDDSLFELGGDSLMALSILARVQKQWNE 1481 P+L T V ++E+AQ+ P ++ F++G DSLM++ ++ Sbjct: 1442 PALLTTQV------QQEVAQVLGHSGSYVP-EVEQGFFDMGMDSLMSVQFRHSLEALLAV 1494 Query: 1482 RIPMAYFINHPTVAGISSYM 1501 +P P++ + SY+ Sbjct: 1495 SLPSTLVFECPSIGDVVSYL 1514 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.319 0.135 0.405 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 128,339,613 Number of extensions: 5476445 Number of successful extensions: 22351 Number of sequences better than 1.0e-05: 145 Number of HSP's gapped: 21822 Number of HSP's successfully gapped: 177 Length of query: 1728 Length of database: 38,378,431 Length adjustment: 120 Effective length of query: 1608 Effective length of database: 24,538,351 Effective search space: 39457668408 Effective search space used: 39457668408 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 123 (52.0 bits)