BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0479.0018.p (464 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ybbX [F] COG0044 Dihydroorotase and related cyclic amidohydrolases 379 e-105 BH2309 [F] COG0044 Dihydroorotase and related cyclic amidohydrol... 374 e-103 BS_yunH [F] COG0044 Dihydroorotase and related cyclic amidohydro... 360 4e-99 DR1153 [F] COG0044 Dihydroorotase and related cyclic amidohydrol... 348 1e-95 YIR027c [F] COG0044 Dihydroorotase and related cyclic amidohydro... 244 3e-64 >ybbX [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 379 bits (974), Expect = e-105, Method: Compositional matrix adjust. Identities = 0/453 (0%), Positives = 0/453 (0%), Gaps = 7/453 (1%) Query: 4 AYELIIRNGDVVLPGEVRKLDVGVQDGKIXXXXXXXXXXXXXXVIDAEGQYVLPGMIDMH 63 Y I + V + + G Q+ + I+ + + Sbjct: 2 QYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQ--GINLIDVAEMYPVPPRP 59 Query: 64 VHFNEPAFGHWEGFRSGSAALAAGGCTCYADMPLNGNPPTVNRAALQLKAEAASGNSAVD 123 + + + N + AL K + + ++ Sbjct: 60 ETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLK 119 Query: 124 YMLWGGLVPGNXXXXXXXXXXXVTGFKAFISNPGGEG-EGRFREVDDGTLFLGMQKXXXX 182 + L ++ + + + ++ Sbjct: 120 RLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVS 179 Query: 183 XXXXXXHAESEDITAMLSAGAVRSGRTGARDFAASRPAMAELEAVSRALLYSERTGCRLH 242 + + + + S + + + Sbjct: 180 NETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFG 239 Query: 243 FVHISTAAAVEMIHAAKRRGLDVTAETCPHYLVLNEDSMEQLGPVAKCAPPLRSTQEQQE 302 + + A T + ++ + +++ Sbjct: 240 TLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQ 299 Query: 303 LWKVLAEGRIDLIASDHSPCPPELKFDPGLTFFEAWGGISGAQSSLELMFHEGVHMRGLP 362 + + + Sbjct: 300 PFVASTLLGATTMDQLKTNIESLHL--- 356 Query: 363 VTQVSALLSGQPARRFGLDHRKGSIAPGLDADLVLLNPKAGYTLAAGDLLYRHKHSPYIG 422 Sbjct: 357 - 415 Query: 423 MTLSCKVTTTVCRGNVVYTAEQGVVSADKGEWL 455 Sbjct: 416 448 >BH2309 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 374 bits (959), Expect = e-103, Method: Compositional matrix adjust. Identities = 0/437 (0%), Positives = 0/437 (0%), Gaps = 6/437 (1%) Query: 5 YELIIRNGDVVLPGEVRKLDVGVQDGKIXXXXXXXXXXXXXX-VIDAEGQYVLPGMIDMH 63 + + + +V G + AE V P Sbjct: 4 HRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQG 63 Query: 64 VHFNEPAFGHWEGFRSGSAALAAGGCTCYADMPLNGNPPTVNRAALQLKAEAASGNSAVD 123 + + +A+ + P +A S Sbjct: 64 LTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQT 123 Query: 124 YMLWGGLVPGNXXXXXXXXXXXVTGFKAFISNPGGEGEGRFREVDDGTLFLGMQKXXXXX 183 L V + + + + + + ++ Sbjct: 124 DYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDT---LDALAEYQRAGKIRYIGVSN 180 Query: 184 XXXXXHAESEDITAMLSAGAVRSGRTGARDFAASRPAMAELEAVSRALLYSERTGCRLHF 243 + + + + S + + + Sbjct: 181 ETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGT 240 Query: 244 VHISTAAAVEMIHAAKRRGLDVTAETCPHYLVLNEDSMEQLGPVAKCAPPLRSTQEQQEL 303 + + A T + ++ + +++ Sbjct: 241 LTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQP 300 Query: 304 WKVLAEGRIDLIASDHSPCPPELKFDPGLTFFEAWGGISGAQSSLELMFHEGVHMRGLPV 363 + + + Sbjct: 301 FVASTLLGATTMDQLKTNIESLHL-- 358 Query: 364 TQVSALLSGQPARRFGLDHRKGSIAPGLDADLVLLNPKAGYTLAAGDLLYRHKHSPYIGM 423 Sbjct: 359 418 Query: 424 TLSCKVTTTVCRGNVVY 440 Sbjct: 419 435 >BS_yunH [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 360 bits (923), Expect = 4e-99, Method: Compositional matrix adjust. Identities = 0/447 (0%), Positives = 0/447 (0%), Gaps = 9/447 (2%) Query: 4 AYELIIRNGDVVLPGEVRKLDVGVQDGKIXXXXXXXXXXXXXXVIDAEGQYVLPGMIDMH 63 Y I + V + + G Q+ + + + + P Sbjct: 2 QYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQG-INLIDVAEMYPVPPRPE 60 Query: 64 VHFNEPAFGHWEGFRSGSAALAAGGCTCYADMPLNGNPPTVNRAALQLKAEAASGNSAVD 123 + + GS N ++A + A +S Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 124 YMLWGGLVPGNXXXXXXXXXXXVTGFKAFISNPGGEGEGRFREVDDGTLFLGMQKXXXXX 183 + G+ S P +D + K Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVS---LLDTLDALAEYQRAGKIRYIG 177 Query: 184 XXXXXHAESEDITAMLSAGAVRSGRTGARDFAASRPAMAELEAVSRALLYSERTGCRLHF 243 + + T ++ + A E Sbjct: 178 VSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLG 237 Query: 244 VHISTAAAVEMIHAAKRRGLDVTAETCPHYLVLNEDSMEQLGPVAKCAPPLRSTQEQQEL 303 T + A R + T + + + Sbjct: 238 FGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVR 297 Query: 304 WKVLAEGRIDLIASDHSPCPPELKFDPGLTFFEAWGGISGAQSSLELMFHEGVHMRGLPV 363 + + + L Sbjct: 298 RQPFVASTLLGATTMDQLKTNIESLHLEL--- 354 Query: 364 TQVSALLSGQPARRFGLDHRKGSIAPGLDADLVLLNPKAGYTLAAGDLLYRHKHSPYIGM 423 Sbjct: 355 -- 412 Query: 424 TLSCKVTTTVCRGNVVYTAEQGVVSAD 450 Sbjct: 413 439 >DR1153 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 348 bits (892), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 0/438 (0%), Positives = 0/438 (0%), Gaps = 11/438 (2%) Query: 4 AYELIIRNGDVVLPGEVRKLDVGVQDGKIXXXXXXXXXXXXXXVIDAEGQYVLPGMIDMH 63 Y I + V + + G Q+ + + + + P Sbjct: 2 QYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQG-INLIDVAEMYPVPPRPE 60 Query: 64 VHFNEPAFGHWEGFRSGSAALAAGGCTCYADMPLNGNPPTVNRAALQLKAEAASGNSAVD 123 + + GS N ++A + A +S Sbjct: 61 TQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKR 120 Query: 124 YMLWGGLVPGNXXXXXXXXXXXVTGFKAFISNPGGEGEGRFREVDDGTLFLGMQKXXXXX 183 + G+ S P +D + K Sbjct: 121 LQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVS---LLDTLDALAEYQRAGKIRYIG 177 Query: 184 XXXXXHAESEDITAMLSAGAVRSGRTGARDFAASRPAMAELEAVSRALLYSERTGCRLHF 243 + + T ++ + A E Sbjct: 178 VSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLG 237 Query: 244 VHISTAAAVEMIHAAKRRGLDVTAETCPHYLVLNEDSMEQLGPVAKCAPPLRSTQEQQEL 303 T + A R + T + + + Sbjct: 238 FGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVR 297 Query: 304 WKVLAEGRIDLIASDHSPCPPELKFDPGLTFFEAWGGISGAQSSLELMFHEGVHMRGLPV 363 + + + Sbjct: 298 RQPFVASTLLGATTMDQLKTNIESLHL-- 355 Query: 364 TQVSALLSGQPARRFGLDHRKGSIAPGLDADLVLLNPKAGYTLAAGDLLY-RHKHSPYIG 422 Sbjct: 356 ---- 411 Query: 423 MTLSCKVTTTVCRGNVVY 440 Sbjct: 412 429 >YIR027c [F] COG0044 Dihydroorotase and related cyclic amidohydrolases Length = 346 Score = 244 bits (622), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 0/404 (0%), Positives = 0/404 (0%), Gaps = 13/404 (3%) Query: 55 VLPGMIDMHVHFNEPAFGHWEGFRSGSAALAAGGCTCYADMPLNGNPPTVNRAALQLKAE 114 + + S + + LK Sbjct: 62 QGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRL 121 Query: 115 AASGNSAVDYMLWGGLVPGNXXXXXXXXXXXVTGFKAFISNPGGEGEGRFREVDDGTLFL 174 + E R + + Sbjct: 122 QTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAE---YQRAGKIRYIGV 178 Query: 175 GMQKXXXXXXXXXXHAESEDITAMLSAGAVRSGRTGARDFAASRPAMAELEAVSRAL-LY 233 + + + + A Sbjct: 179 SNETAFGVMRYLHLADKHDL--PRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCL 236 Query: 234 SERTGC--RLHFVHISTAAAVEMIHAAKRRGLDVTAETCPHYLVLNEDSMEQLGPVAKCA 291 T L+ + A + G + + ++ Sbjct: 237 GFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFV 296 Query: 292 PPLRSTQEQQELWKVLAEGRIDLIASDHSPCPPELKFDPGLTFFEAWGGISGAQSSLELM 351 Sbjct: 297 356 Query: 352 FHEGVHMRGLPVTQVSALLSGQPARRFGLDHRKGSIAPGLDADLVLLNPKAGYTLAAGDL 411 Sbjct: 357 ----- 411 Query: 412 LYRHKHSPYIGMTLSCKVTTTVCRGNVVYTAEQGVVSADKGEWL 455 Sbjct: 412 455 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.318 0.135 0.409 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 32,863,941 Number of extensions: 1250757 Number of successful extensions: 2613 Number of sequences better than 1.0e-05: 34 Number of HSP's gapped: 2523 Number of HSP's successfully gapped: 38 Length of query: 464 Length of database: 38,378,431 Length adjustment: 110 Effective length of query: 354 Effective length of database: 25,691,691 Effective search space: 9094858614 Effective search space used: 9094858614 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 118 (50.1 bits)