BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0472.0043.p (174 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value L108967 [KR] COG0454 Histone acetyltransferase HPA2 and related ... 151 6e-37 BH0426 [KR] COG0454 Histone acetyltransferase HPA2 and related a... 116 2e-26 SA0612 [KR] COG0454 Histone acetyltransferase HPA2 and related a... 95 7e-20 FN0055 [KR] COG0454 Histone acetyltransferase HPA2 and related a... 90 2e-18 CAC1416 [KR] COG0454 Histone acetyltransferase HPA2 and related ... 84 1e-16 >L108967 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases Length = 162 Score = 151 bits (381), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 74/162 (45%), Positives = 110/162 (67%), Gaps = 5/162 (3%) Query: 5 IRELVPEDAAELISLQYRLDEESAFMLLEPGERQTGIKQAEDMIRSFASAENSALIGAAA 64 IR + DA +Q +LD ES FM+LEP ER+ + I F L+GA Sbjct: 4 IRRIDLCDARLFWDVQKQLDTESKFMMLEPEERRFDFSRTIGRISRF-----DFLVGADV 58 Query: 65 SGRLAGFLSVRGGSARRNRHSAYIVTGILKEFQGMGLGSALFKELEKWAKETGIIRLELT 124 G+ GFLS + G+A R R++AY+V GI++EFQ G+GS LF+ELE+WAKE + RLELT Sbjct: 59 DGKFVGFLSAKRGNANRIRNTAYVVVGIIEEFQHQGIGSQLFEELERWAKEKAVKRLELT 118 Query: 125 IMVHNERALALYTKNGFEIEGIKKKSLKVEGNWVDEYYMSRI 166 +M++N A+AL+ K+GF IEG++++++ V+G ++DE+YMS+I Sbjct: 119 VMINNYAAIALFQKHGFTIEGVRREAVCVDGKYIDEFYMSKI 160 >BH0426 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases Length = 165 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 63/163 (38%), Positives = 91/163 (55%), Gaps = 1/163 (0%) Query: 5 IRELVPEDAAELISLQYRLDEESAFMLLEPGERQTGIKQAEDMIRSFASAENSALIGAAA 64 IR + DA + L +D+ + ML EP E++ ++Q MI NS A Sbjct: 3 IRPIDTLDAEAFLDLSKAVDQ-TGMMLFEPREKKWTVEQQRKMIDGILGRRNSMTFVAEE 61 Query: 65 SGRLAGFLSVRGGSARRNRHSAYIVTGILKEFQGMGLGSALFKELEKWAKETGIIRLELT 124 GRL G+++ GG+ +R H AYIV G+ +E QG G+ + LF L WAK I RLELT Sbjct: 62 YGRLIGYITAIGGNVKRTAHRAYIVVGVREEEQGRGIATELFNRLFNWAKSVDITRLELT 121 Query: 125 IMVHNERALALYTKNGFEIEGIKKKSLKVEGNWVDEYYMSRIF 167 ++ N +A LY K GF +EG K SL ++G V+EYY+ ++ Sbjct: 122 VIKDNRKAFQLYQKLGFVLEGEKVHSLMIDGKPVNEYYLYKLL 164 >SA0612 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases Length = 168 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 48/166 (28%), Positives = 84/166 (50%) Query: 1 MKVTIRELVPEDAAELISLQYRLDEESAFMLLEPGERQTGIKQAEDMIRSFASAENSALI 60 M IR + +D IS+ ++ +ES +M PGE + A + + ++ + + Sbjct: 1 MAHIIRRVSIKDVENFISMLAKIYDESPYMFYTPGEYDPSVTSASKQLEEYITSPHKVIF 60 Query: 61 GAAASGRLAGFLSVRGGSARRNRHSAYIVTGILKEFQGMGLGSALFKELEKWAKETGIIR 120 A + +L GF V +R +H A I G+ K +Q G+G AL + W I R Sbjct: 61 VAESDEQLVGFAFVNTTPFQRIKHVAKIDLGVKKLYQHRGIGQALLDAIMAWCLNNQIHR 120 Query: 121 LELTIMVHNERALALYTKNGFEIEGIKKKSLKVEGNWVDEYYMSRI 166 +E + ++N+ AL L+ F+IEG+ K L ++G + D+Y M++I Sbjct: 121 IEANVPLNNQPALELFKSADFQIEGVLKDKLFIDGKYYDDYMMAKI 166 >FN0055 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases Length = 168 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 49/146 (33%), Positives = 82/146 (56%), Gaps = 2/146 (1%) Query: 1 MKVTIRELVPEDAAELISLQYRLDEESAFMLLEPGERQTGIKQAEDMIRSFASAENSALI 60 M++ IRE+ ED EL+ ++ E+ F+L P E + + ++ I+ S+E S Sbjct: 4 MEIEIREV--EDYKELLDFMRKVKGETNFLLGYPDEIKLSYEDEKEHIKKVKSSETSNHF 61 Query: 61 GAAASGRLAGFLSVRGGSARRNRHSAYIVTGILKEFQGMGLGSALFKELEKWAKETGIIR 120 A ++ G S G +AR+ +H I +LKE+ G G+ + L ++L WAKE GI + Sbjct: 62 VAMKEDKMIGCTSFNGNTARKMKHYGTIGISVLKEYWGRGVATVLLEKLISWAKEKGIKK 121 Query: 121 LELTIMVHNERALALYTKNGFEIEGI 146 + L + +N+RA+ LY K GF++EG Sbjct: 122 INLDVFENNKRAIELYEKFGFKLEGC 147 >CAC1416 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases Length = 171 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 48/162 (29%), Positives = 82/162 (50%), Gaps = 1/162 (0%) Query: 3 VTIRELVPEDAAELISLQYRLDEESAFMLLEPGERQTGIKQAEDMIRSFASAENSALIGA 62 + +RE++ ED +I ++ EES F+ GE + + + + I + + S I A Sbjct: 5 IIVREVLKEDDLGMIEYLKKIAEESNFLTFGKGEVKKSVLEEREFIENAIKNKTSLFIVA 64 Query: 63 AASGRLAGFLSVRGGSARRNRHSAYIVTGILKEFQGMGLGSALFKELEKWAKETGIIR-L 121 + G++ G L+ G R RH+ +LKE+ G+G+G L L W+K+ I+R + Sbjct: 65 ESEGKIIGNLNFSTGENSRVRHTGEFGVSVLKEYWGLGVGRKLIMNLIAWSKKNHIVRKI 124 Query: 122 ELTIMVHNERALALYTKNGFEIEGIKKKSLKVEGNWVDEYYM 163 L + N RA+ LY GF EG K+ ++G + D + M Sbjct: 125 NLRVRTDNYRAIKLYESLGFVNEGTIKRDFLIDGEFYDSFSM 166 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.317 0.135 0.375 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 12,430,524 Number of extensions: 473519 Number of successful extensions: 1335 Number of sequences better than 1.0e-05: 24 Number of HSP's gapped: 1344 Number of HSP's successfully gapped: 24 Length of query: 174 Length of database: 38,378,431 Length adjustment: 99 Effective length of query: 75 Effective length of database: 26,960,365 Effective search space: 2022027375 Effective search space used: 2022027375 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 112 (47.8 bits)