BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0470.0012.p (523 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAP0121 [TQ] COG2508 Regulator of polyketide synthase expression 150 4e-36 CAC1426 [TQ] COG2508 Regulator of polyketide synthase expression 69 2e-11 BS_ycgP [TQ] COG2508 Regulator of polyketide synthase expression 61 3e-09 BS_yukF [TQ] COG2508 Regulator of polyketide synthase expression 60 9e-09 BS_yunI [TQ] COG2508 Regulator of polyketide synthase expression 58 3e-08 >CAP0121 [TQ] COG2508 Regulator of polyketide synthase expression Length = 211 Score = 150 bits (380), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 0/515 (0%), Positives = 0/515 (0%), Gaps = 52/515 (10%) Query: 43 FAPEFIYVGKRSMLPGNAANMENASLMLINDAELPVQEDVESSPNIIEFTAGED-VFEIY 101 + + P L + + + E + Sbjct: 42 ATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKT--IGLYNSKAENIIKTCRILLEQ 99 Query: 102 NQTRELFLEKAETEQAKATLLKAFAAGKGMDHIVSVAADILGNPVIVIDLSYKVLAYSDS 161 + A A ++A D V Sbjct: 100 HNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQV 159 Query: 162 -EITDPVWRDNLQKGYCSYDFIAAVQK-----------MKSVQNGAKSGEPYEVFCSGS- 208 E V + + + Sbjct: 160 EEKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSC 219 Query: 209 ---------------AAAKMVARIKIGDKPVGNLILLGTERPVHPRDRDLAAFAGEMVAA 253 Sbjct: 220 279 Query: 254 ELQKNSFYRNSAHAVYDELIYDLLENHLSGKELVQERLRSGN------IRLTGRLSVLVL 307 Sbjct: 280 339 Query: 308 DIVQYDASGKYNGYLRDRISTLFTAERQIFYNGHIVSIRER-KLKAARMDCGPDIREFLT 366 Sbjct: 340 ------- 392 Query: 367 ANQIRLGISSEFSDIADCRKYYLQAVKALEIGLIAMPADPVVLYSDVQLYDILS-AHTQG 425 Sbjct: 393 452 Query: 426 DYREVCHPALLTLREYDGKHHADLYHTLFIYLKNNRQLQRTATELFIHRNTLRYRLHQIS 485 Sbjct: 453 512 Query: 486 VLIHVDLDNIDNVLKLYMSYKMTAYLDRLKEAGEC 520 Sbjct: 513 ------ 541 >CAC1426 [TQ] COG2508 Regulator of polyketide synthase expression Length = 397 Score = 68.6 bits (166), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 90/178 (50%), Gaps = 4/178 (2%) Query: 338 YNGHIVSI---RERKLKAARMDCGPDIREFLTANQIRLGISSEFSDIADCRKYYLQAVKA 394 YN I+ + +R +K M+ +I + +G+ EFS++ D + +A + Sbjct: 214 YNSIILMLPKNEKRTIKNIAMNIIEEIISKAKNTSVNIGVGGEFSELRDFKISVSEAHRC 273 Query: 395 LEIGLIAMPADPVVLYSDVQLYDIL-SAHTQGDYREVCHPALLTLREYDGKHHADLYHTL 453 L++ + + V+ Y ++ +Y + + ++ L L +YD K+ +L +TL Sbjct: 274 LKVLKLNNDNNTVISYDELGIYKLFFQMDNLEEMKKFYLDVLKKLIDYDSKNTTELMNTL 333 Query: 454 FIYLKNNRQLQRTATELFIHRNTLRYRLHQISVLIHVDLDNIDNVLKLYMSYKMTAYL 511 +Y+K + + RTA +LFIHRNTL+YR+ +I + L +++ + + K+ +L Sbjct: 334 EMYIKESTNINRTAEKLFIHRNTLKYRIRRIEEITKCSLKDVNVLFNFDTALKIKKFL 391 >BS_ycgP [TQ] COG2508 Regulator of polyketide synthase expression Length = 411 Score = 61.2 bits (147), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 65/239 (27%), Positives = 109/239 (45%), Gaps = 22/239 (9%) Query: 282 SGKELVQERLRSGNIRLTGRLSVLVLDIVQYDASG----KYN--GYL--RDRISTLFTAE 333 S KEL +E R + L SV++L D K N YL RD++S + T E Sbjct: 170 SEKELRREAERINTV-LPSMFSVVILHAANGDGEAVEDLKENIRSYLNLRDKVSHVLTIE 228 Query: 334 RQIFYNGHIVSIRERKLKAARMDCGPDIREFLT-------ANQIRLGISSEFSDIADCRK 386 I IV + + I + LT I +GI +E++ + K Sbjct: 229 SNIV----IVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEYNHLLKLGK 284 Query: 387 YYLQAVKALEIGLIAMPADPVVL-YSDVQLYDIL-SAHTQGDYREVCHPALLTLREYDGK 444 Y +A++ ++ I + + Y+ + +Y L S + ++ E + L L+ D + Sbjct: 285 SYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKDLALLKAKDEE 344 Query: 445 HHADLYHTLFIYLKNNRQLQRTATELFIHRNTLRYRLHQISVLIHVDLDNIDNVLKLYM 503 +L TL +YL NN + + A +LFIH+NTL YR+ QI+ + +DL + +LY+ Sbjct: 345 SSTELLKTLEVYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDLSDFRTRCQLYL 403 >BS_yukF [TQ] COG2508 Regulator of polyketide synthase expression Length = 211 Score = 60.1 bits (144), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 0/397 (0%), Positives = 0/397 (0%), Gaps = 35/397 (8%) Query: 132 DHIVSVAADILGNPVIVIDLSYKVLAYSD-SEITDPVWRDNLQKGYCSYDFIAAVQKMKS 190 + V Y + + K ++ Sbjct: 33 LIA----VLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAEN 88 Query: 191 VQNGAKSGEPYEV--FCSGSAAAKMVARIKIGDKPVGNLILLGTERPVHPRDRDLAAFAG 248 + + AA + + + V G Sbjct: 89 IIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRT 148 Query: 249 EMVAAELQKNSFYRNSAHAVYDELIYDLLENHLSGKELVQERLRSGNIRLTGRLSVLVLD 308 + + + + + + L G+ R + L Sbjct: 149 QFAPGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208 Query: 309 IVQYDASGKYNGYLRDRISTLFTAERQIFYNGHIVSIRERKLKAARMDCGP--DIREFLT 366 + Sbjct: 209 V----- 263 Query: 367 ANQ-----------IRLGISSEFSDIADCRKYYLQAVKALEIG-LIAMPADPVVLYSDVQ 414 Sbjct: 264 323 Query: 415 LY---DILSAHTQ--GDYREVCHPALLTLREYDGKHHADLYHTLFIYLKNNRQLQRTATE 469 Sbjct: 324 ---- 379 Query: 470 LFIHRNTLRYRLHQISVLIHVDLDNIDNVLKLYMSYK 506 Sbjct: 380 416 >BS_yunI [TQ] COG2508 Regulator of polyketide synthase expression Length = 531 Score = 58.2 bits (139), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 83/403 (20%), Positives = 162/403 (40%), Gaps = 46/403 (11%) Query: 127 AGKGMDHIVSVAADILGNPVIVIDLSYKVLAYSDSEITDPVWRDNLQKGYCSYDFIAAVQ 186 +GKG+ ++ +DIL PV+++D K+L+ S+ + Sbjct: 148 SGKGLQSLLKKVSDILQLPVLLLDQHAKMLS-------------------ASHQISVETE 188 Query: 187 KMKSVQNGAKSGEPYEVFCSGS-AAAKMVARIKIGDKPVGNLILLGTERPVHPRDRDLAA 245 K+K N SG + F + S V I +K G L++ V D+ L Sbjct: 189 KLKGTLNTV-SGPFFTCFSTISDQKTYSVLPIYNHEKNCGYLLIPDM---VQAGDKGLIL 244 Query: 246 F---AGEMVAAELQKNSFYRNSAHAVYDELIYDLLENHLSGKELVQERLRSGNIRLTGRL 302 A +++ EL K + + + +E + +E S + ++ R + +R + Sbjct: 245 TIEQAANVISFELLKENALKQFSRRARNEFFNNFIERTFSSDDEIKNRAKEFKLRWDQKY 304 Query: 303 SVLVLDIVQYDASGKY--NGYLRDRISTLFTAERQIF-YNGHI-----VSIRERKLKAAR 354 + + + D S + N D + E F + H V I + + Sbjct: 305 MCIAGKLDRNDESISFTENQLASDSVFEFLEGELSAFPFPPHFFMKGNVGIILIEATDSW 364 Query: 355 MDCGPDIREFLTANQ----------IRLGISSEFSDIADCRKYYLQAVKALEIGLIAMPA 404 + + FL Q + GIS+ + D + +A AL+ G ++ Sbjct: 365 SEMHASVISFLEQFQTQVSAQFKRTVSFGISNICQKLIDVPDAFTEASDALQSGHLSRST 424 Query: 405 DPVVLYSDVQLYDILSAHTQGDYREVCHPALLTLREYDGKHHADLYHTLFIYLKNNRQLQ 464 + +Y + ++L D ++ + L +L E + + L HTL +YL+ + Q+ Sbjct: 425 AFIQVYHAKDVPELLRLLPVEDLKKFYNSTLQSLAEKQQEDQS-LLHTLSVYLETHCQIS 483 Query: 465 RTATELFIHRNTLRYRLHQISVLIHVDLDNIDNVLKLYMSYKM 507 TA L++HRNT+ YRL + L+ L + + ++L ++ +M Sbjct: 484 ETAKRLYVHRNTVIYRLEKCEELLGKSLKDPETTMRLRLALRM 526 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.320 0.136 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 36,045,446 Number of extensions: 1487492 Number of successful extensions: 3038 Number of sequences better than 1.0e-05: 9 Number of HSP's gapped: 3036 Number of HSP's successfully gapped: 10 Length of query: 523 Length of database: 38,378,431 Length adjustment: 111 Effective length of query: 412 Effective length of database: 25,576,357 Effective search space: 10537459084 Effective search space used: 10537459084 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 118 (50.1 bits)