BLASTP 2.2.18 [Mar-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0462.0007.p (645 letters) Database: COG 115,334 sequences; 38,378,431 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC3012 [R] COG0488 ATPase components of ABC transporters with d... 641 0.0 BS_yfmR [R] COG0488 ATPase components of ABC transporters with d... 587 e-167 lin1989 [R] COG0488 ATPase components of ABC transporters with d... 578 e-165 sll0912 [R] COG0488 ATPase components of ABC transporters with d... 572 e-163 alr1297 [R] COG0488 ATPase components of ABC transporters with d... 554 e-157 >CAC3012 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains Length = 632 Score = 641 bits (1653), Expect = 0.0, Method: Compositional matrix adjust. Identities = 317/642 (49%), Positives = 435/642 (67%), Gaps = 14/642 (2%) Query: 1 MNIMTVEHLSKSYGEKTLFRDASFGMDDRNKIGVIGVNGTGKSTFLKIIAGLDTPDDGQI 60 MN++T+E++SKSYGEKTL S + + KIG+IG+NGTGKST LKI+ G+ D G I Sbjct: 1 MNLITLENISKSYGEKTLLNKISLSISEGEKIGLIGINGTGKSTLLKILCGIQEYDSGNI 60 Query: 61 AIGNAVRVQYLAQNPPYEPDNTVLQQVFAGDEPELAAMREYMETLALLESRPGDSALERR 120 N++ + YL+QN + + TVL+Q+F G+ E+ +REY L P D +++ Sbjct: 61 ITSNSLSMSYLSQNENFYDNATVLEQIFQGNSKEMNLLREYETALENSAMHPDDEKVQKT 120 Query: 121 LVQIGQAIDAAGTWQLESEAKTVLTKLGITQFDARMESLSGGQRKRVALAAALITPSELL 180 L+ + + +DA W +ES AKT+LTKLGI F+A++++LSGGQ+KR+ LA LITPS LL Sbjct: 121 LLNLTEQMDALDLWNIESNAKTILTKLGIKNFNAKIKTLSGGQKKRICLAQTLITPSNLL 180 Query: 181 ILDEPTNHIDTDSVAWLEQYLQKRRGALLMVTHDRYFLERVASVMLELDGGQLYRYEANY 240 +LDEPTNH+D +++ WLEQYL + ++ M+THDRYFL+R+++ + EL G LY Y NY Sbjct: 181 VLDEPTNHLDNETIEWLEQYLTSTKSSVFMITHDRYFLDRISNKIFELYNGNLYSYVGNY 240 Query: 241 SRFXXXXXXXXXXXXXXXXXXXNLLRTELAWIRRGAKARSTKQKARIDRFEKLKESQGPA 300 S + NLLR ELAWIRRGAKARSTKQKARI RF++L Sbjct: 241 SVYLEKKLEREQLEISSKQKKDNLLRRELAWIRRGAKARSTKQKARIQRFDELNSQDDTI 300 Query: 301 SAGALDISVASTRLGRKIIEMKDLTKSLDGRTLIKDLTYIAVPQDRVGIVGPNGSGKSTL 360 ++IS + +RLG+K+IE+K+L KS +G IK+ ++I DR+GIVG NG GKSTL Sbjct: 301 IQDKIEISTSGSRLGKKVIEIKNLNKSFNGTEFIKNFSFIFSKGDRIGIVGHNGIGKSTL 360 Query: 361 LNLIAGKLQPDRGEVELGATVKLGYFTQEHQDMDDSLRVIEYVKEEAEIIRTADGSVITA 420 LN+I GK PD G ++LGATVK+GYF+Q+ +M+++LRVI+Y+KE AE IR ++ +I+A Sbjct: 361 LNIICGKTSPDSGTIDLGATVKIGYFSQDSSNMNENLRVIDYIKEGAEFIRDSNNELISA 420 Query: 421 GQMLERFLFPPAMQWTPIAKLSGGEKRRLYLLRVLMGAPNVLLLDEPTNDLDIGTLAVLE 480 +MLE+FLF MQWTPI KLSGGE+RRLYLLR+LM APNVL+LDEPTNDLDI TL +LE Sbjct: 421 SKMLEKFLFSSEMQWTPILKLSGGERRRLYLLRILMEAPNVLILDEPTNDLDIQTLTILE 480 Query: 481 DYLDEFPGVVFTVSHDRFFLDRTVDKLIAFE-NGSIRLHVGNYSEYEEWMANNIPARGGD 539 DYL F G + TVSHDR+FLD+ +KL+ F+ NG I + GNYS+Y E + + Sbjct: 481 DYLQYFEGTILTVSHDRYFLDKLANKLLIFKGNGVIDYNTGNYSDYLEKSKSEEKLEMAN 540 Query: 540 TPKEAGTGKNSSAPEQGQTVPAAPPAREKLKFTFKEQREYEGIDEAIEQAEQHLADISAQ 599 TP + V + P KLKF+FKEQ EYE ID IE AE L I A+ Sbjct: 541 TPTK-------------NKVKSEKPKSTKLKFSFKEQMEYEKIDSVIEAAENELTSIEAK 587 Query: 600 MEAAFADSGKLQELVEKQRQGEAELERLMERWTYLNELAEKI 641 + +A +D L++L+ ++++ E +L+ L +RW YLNELAE+I Sbjct: 588 INSAGSDYMLLEDLMPQKKELEEKLQTLYDRWEYLNELAERI 629 >BS_yfmR [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains Length = 629 Score = 587 bits (1513), Expect = e-167, Method: Compositional matrix adjust. Identities = 309/642 (48%), Positives = 435/642 (67%), Gaps = 16/642 (2%) Query: 1 MNIMTVEHLSKSYGEKTLFRDASFGMDDRNKIGVIGVNGTGKSTFLKIIAGLDTPDDGQI 60 M+I+ E+L K+YG+KTLF SF +++ +IG+IG NGTGKST LK+IAGL++ ++G+I Sbjct: 1 MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKSTLLKVIAGLESIEEGEI 60 Query: 61 AIGNAVRVQYLAQNPPYEPDNTVLQQVFAGDEPELAAMREYMETLALLESRPGDSALERR 120 +V+V++L Q+P TVL+ +++G+ + +REY + L L P + ++ Sbjct: 61 TKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYEKALYELGKDPENEQRQKH 120 Query: 121 LVQIGQAIDAAGTWQLESEAKTVLTKLGITQFDARMESLSGGQRKRVALAAALITPSELL 180 L+ +DA W + AKTVL+KLG+ + LSGGQ+KRVA+A LI P++LL Sbjct: 121 LLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELSGGQKKRVAIAKNLIQPADLL 180 Query: 181 ILDEPTNHIDTDSVAWLEQYLQKRRGALLMVTHDRYFLERVASVMLELDGGQLYRYEANY 240 ILDEPTNH+D +++ WLE YL + GA+++VTHDRYFL RV + + EL+ G LY Y+ NY Sbjct: 181 ILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFLNRVTNRIYELERGSLYTYKGNY 240 Query: 241 SRFXXXXXXXXXXXXXXXXXXXNLLRTELAWIRRGAKARSTKQKARIDRFEKLKESQGPA 300 F NLLR ELAW+RRGAKARSTKQKARIDR E LKE GP Sbjct: 241 EVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGAKARSTKQKARIDRVETLKEQTGPQ 300 Query: 301 SAGALDISVASTRLGRKIIEMKDLTKSLDGRTLIKDLTYIAVPQDRVGIVGPNGSGKSTL 360 S+G+LD ++ S RLG+++IE +++ + DGR L+ + +P +R+GI+GPNG GK+TL Sbjct: 301 SSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLVDRFNELVIPGERIGIIGPNGIGKTTL 360 Query: 361 LNLIAGKLQPDRGEVELGATVKLGYFTQEHQDMDDSLRVIEYVKEEAEIIRTADGSVITA 420 LN +AG+ PD G++ +G TV++GY+TQ+H +M+ L+VI+Y+KE AE+++TADG +ITA Sbjct: 361 LNALAGRHTPDGGDITIGQTVRIGYYTQDHSEMNGELKVIDYIKETAEVVKTADGDMITA 420 Query: 421 GQMLERFLFPPAMQWTPIAKLSGGEKRRLYLLRVLMGAPNVLLLDEPTNDLDIGTLAVLE 480 QMLERFLFP +MQ T I KLSGGEKRRLYLL+VLM PNVL LDEPTNDLD TL+VLE Sbjct: 421 EQMLERFLFPRSMQQTYIRKLSGGEKRRLYLLQVLMQEPNVLFLDEPTNDLDTETLSVLE 480 Query: 481 DYLDEFPGVVFTVSHDRFFLDRTVDKLIAFE-NGSIRLHVGNYSEYEEWMANNIPARGGD 539 DY+D+FPGVV TVSHDR+FLDR VD+LI FE NG I G+YS+Y E Sbjct: 481 DYIDQFPGVVITVSHDRYFLDRVVDRLIVFEGNGVISRFQGSYSDYME------------ 528 Query: 540 TPKEAGTGKNSSAPEQGQTVPAAPPAREKLKFTFKEQREYEGIDEAIEQAEQHLADISAQ 599 E+ K + P + A P +++ K ++K+Q E++GI++ I Q E+ + A Sbjct: 529 ---ESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWDGIEDKIAQLEEKHEQLEAD 585 Query: 600 MEAAFADSGKLQELVEKQRQGEAELERLMERWTYLNELAEKI 641 + AA +D GK+QEL+ +Q + ELE M+RWT L+ + E++ Sbjct: 586 IAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMIEEL 627 >lin1989 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains Length = 630 Score = 578 bits (1491), Expect = e-165, Method: Compositional matrix adjust. Identities = 299/642 (46%), Positives = 411/642 (64%), Gaps = 15/642 (2%) Query: 1 MNIMTVEHLSKSYGEKTLFRDASFGMDDRNKIGVIGVNGTGKSTFLKIIAGLDTPDDGQI 60 M + VE+L+K+YGEK+LF + S + + +IG+IGVNGTGKST L+II+G ++ D G + Sbjct: 1 MKQLKVENLTKTYGEKSLFENISLTITEGERIGLIGVNGTGKSTLLQIISGSESGDKGSV 60 Query: 61 AIGNAVRVQYLAQNPPYEPDNTVLQQVFAGDEPELAAMREYMETLALLESRPGDSALERR 120 + YLAQ+P + ++TVL VF GD L AMR+Y E L + ++ L Sbjct: 61 TKAKDYTIGYLAQDPVFNEEDTVLSAVFDGDTAALRAMRKYEEVLLAMSLDAENTKLHDA 120 Query: 121 LVQIGQAIDAAGTWQLESEAKTVLTKLGITQFDARMESLSGGQRKRVALAAALITPSELL 180 Q +DA+ W + +EAKT+L +LGIT A++ LSGGQRKRV LA LI +LL Sbjct: 121 YTAASQEMDASAAWDMNTEAKTILERLGITDLTAKISELSGGQRKRVGLAQVLIETPDLL 180 Query: 181 ILDEPTNHIDTDSVAWLEQYLQKRRGALLMVTHDRYFLERVASVMLELDGGQLYRYEANY 240 ILDEPTNH+D S+ WLE+YL + +GA+L+VTHDRYFL+RV + M+ELD G YRY NY Sbjct: 181 ILDEPTNHLDFQSIRWLEEYLNRFKGAVLLVTHDRYFLDRVTNHMVELDRGSAYRYVGNY 240 Query: 241 SRFXXXXXXXXXXXXXXXXXXXNLLRTELAWIRRGAKARSTKQKARIDRFEKL-KESQGP 299 +F NL R ELAW+RRG + R+TKQ AR DRF L K+ + Sbjct: 241 EKFMESKAIRMENEVRESEKNKNLYRKELAWMRRGPQGRATKQNARQDRFHDLEKKVKTK 300 Query: 300 ASAGALDISVASTRLGRKIIEMKDLTKSLDGRTLIKDLTYIAVPQDRVGIVGPNGSGKST 359 L I ++RLG+ + E+K+L K D + +++D + I P +R+GI G NG+GKST Sbjct: 301 IDDSELAIDFVTSRLGKDVFELKNLEKRFDEKQVLQDFSLIIQPGERLGITGNNGTGKST 360 Query: 360 LLNLIAGKLQPDRGEVELGATVKLGYFTQEHQDMDDSLRVIEYVKEEAEIIRTADGSVIT 419 LLN++AGKL PD GEV G TV++GY+TQ++++MD +R+I Y++E E + T+ G VI+ Sbjct: 361 LLNMLAGKLTPDAGEVITGQTVQIGYYTQQNEEMDPDMRMIAYLQEAGEQVTTSGGEVIS 420 Query: 420 AGQMLERFLFPPAMQWTPIAKLSGGEKRRLYLLRVLMGAPNVLLLDEPTNDLDIGTLAVL 479 MLERFLFPP I LSGGEKRRL+LLR+LM PNVLLLDEPTNDLD TL VL Sbjct: 421 VSAMLERFLFPPNSHGKKIGSLSGGEKRRLFLLRILMERPNVLLLDEPTNDLDTQTLTVL 480 Query: 480 EDYLDEFPGVVFTVSHDRFFLDRTVDKLIAFEN-GSIRLHVGNYSEY-EEWMANNIPARG 537 EDYL+ F G V TVSHDR+FLD+ V+KL+ F G + + G YS+Y +E A PA+ Sbjct: 481 EDYLESFNGTVITVSHDRYFLDKVVNKLLVFRAIGEVEIFYGEYSDYLKELEAKGKPAKS 540 Query: 538 GDTPKEAGTGKNSSAPEQGQTVPAAPPAREKLKFTFKEQREYEGIDEAIEQAEQHLADIS 597 K A T S+PE+ +EK+K T++EQ E++GI++AI EQ + ++ Sbjct: 541 --MKKMANTSAEKSSPEK----------KEKVKLTYQEQLEWDGIEDAISDLEQDIESLN 588 Query: 598 AQMEAAFADSGKLQELVEKQRQGEAELERLMERWTYLNELAE 639 +E AD K E+ E E+ELE++MERW +L++ AE Sbjct: 589 ETLEQTGADFTKAAEISELITAKESELEQMMERWEFLSQYAE 630 >sll0912 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains Length = 636 Score = 572 bits (1475), Expect = e-163, Method: Compositional matrix adjust. Identities = 298/641 (46%), Positives = 427/641 (66%), Gaps = 12/641 (1%) Query: 1 MNIMTVEHLSKSYGEKTLFRDASFGMDDRNKIGVIGVNGTGKSTFLKIIAGLDTPDDGQI 60 M ++TV+ L K +G K + RDA+F ++ +++G+IGVNG+GKST LK+IAGL+ D G+ Sbjct: 1 MALITVQSLRKDFGIKEILRDATFNIEPGDRVGLIGVNGSGKSTLLKMIAGLEPFDGGEY 60 Query: 61 AIGNAVRVQYLAQNPPYEPDNTVLQQVFAGDEPELAAMREYMETLALLESRPGDSALERR 120 ++ +V YL Q P + D TVL+QVF + +++Y L + D L + Sbjct: 61 WCNSSAKVVYLPQQPEMDGDRTVLEQVFVDSGEQWQLVKQYELLSDKLAHQGSDEQLLNQ 120 Query: 121 LVQIGQAIDAAGTWQLESEAKTVLTKLGITQFDARMESLSGGQRKRVALAAALITPSELL 180 L + ++ +G W+LE++AK +LT+LG+ DA++ LSGG RKRVA+AAAL++ ++L Sbjct: 121 LSALSAQMETSGAWELETQAKIILTQLGVDHLDAKVGDLSGGYRKRVAIAAALLSQPDVL 180 Query: 181 ILDEPTNHIDTDSVAWLEQYLQKRRGALLMVTHDRYFLERVASVMLELDGGQLYRYEANY 240 ++DEPTNH+D SV WL+ YLQ+ RGALL++THDRYFL+RV + +LE+D G+LY Y NY Sbjct: 181 LMDEPTNHLDAFSVEWLQSYLQRFRGALLLITHDRYFLDRVTNRILEIDQGELYSYNGNY 240 Query: 241 SRFXXXXXXXXXXXXXXXXXXXNLLRTELAWIRRGAKARSTKQKARIDRFEKLKESQGPA 300 + +LR EL W++RG KARSTKQKARIDR + ++E+ Sbjct: 241 GYYLTKKAEAEESEQSSQKKHRGVLRRELEWLKRGPKARSTKQKARIDRIQDMQETSFKT 300 Query: 301 SAGALDISVASTRLGRKIIEMKDLTKSLDGRTLIKDLTYIAVPQDRVGIVGPNGSGKSTL 360 G +DIS A R+G+K++E+++++K + + LIKD +YI P DRVGIVG NG GKSTL Sbjct: 301 GTGKVDISTAGRRIGKKVVELENISKGFENKQLIKDFSYIFTPGDRVGIVGKNGVGKSTL 360 Query: 361 LNLIAGKLQPDRGEVELGATVKLGYFTQEHQD--MDDSLRVIEYVKEEAEIIRTADGSVI 418 +N+I G+L+PD+G V++G+T+ GYF Q D ++ + RVI+Y+K AE+I+T DG VI Sbjct: 361 MNMITGRLEPDQGTVDIGSTIHFGYFDQHSDDLSLNPNQRVIDYLKSVAELIKTTDGEVI 420 Query: 419 TAGQMLERFLFPPAMQWTPIAKLSGGEKRRLYLLRVLMGAPNVLLLDEPTNDLDIGTLAV 478 TAGQMLERFLFPP Q+ PIAKLSGGEKRRL+LLRVLM APNVL+LDEPTNDLD+ TLAV Sbjct: 421 TAGQMLERFLFPPNQQFAPIAKLSGGEKRRLFLLRVLMRAPNVLILDEPTNDLDVQTLAV 480 Query: 479 LEDYLDEFPGVVFTVSHDRFFLDRTVDKLIAF-ENGSIRLHVGNYSEYEEW-MANNIPAR 536 LEDYL++F G V VSHDR+FLDRTV+ + AF E G +R + GNY+ Y E+ A + A Sbjct: 481 LEDYLEDFNGCVIVVSHDRYFLDRTVETIFAFEEEGELRQYPGNYTLYLEYKKAEQVRAN 540 Query: 537 GGDTPKEAGTGKNSSAPEQGQTVPAAPPAREKLKFTFKEQREYEGIDEAIEQAEQHLADI 596 +T + S P T + + K K ++KE+REYE +++ I Q E+ A + Sbjct: 541 QEETELK------KSQPVASVTTKVSQDSSSK-KLSYKEKREYEQLEQQIPQLEEEKAQL 593 Query: 597 SAQM-EAAFADSGKLQELVEKQRQGEAELERLMERWTYLNE 636 AQ+ +++ + +LQ L E+ +++ ERW L E Sbjct: 594 EAQLYQSSNGNFTELQNLTERLANLSESIDQKTERWLTLAE 634 >alr1297 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains Length = 359 Score = 554 bits (1428), Expect = e-157, Method: Compositional matrix adjust. Identities = 0/656 (0%), Positives = 0/656 (0%), Gaps = 23/656 (3%) Query: 1 MNIMTVEHLSKSYGEKTLFRDASFGMDDRNKIGVIGVNGTGKSTFLKIIAGLDTPDDGQI 60 M TV ++ + G G + + D ++ Sbjct: 1 MQAATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGLLETARTLPDADAFGVARL 60 Query: 61 AIGNAVRVQYLAQNPPYEPDNTVLQQVFAGDEPELAAMREYMETLALLESRPGDSALERR 120 +R + + + + E LA LE D + Sbjct: 61 EEALRLRAGGITKPVLLLEGFFDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVW 120 Query: 121 LVQIGQAIDAAGTWQLESEAKTVLTKLGITQFDARMESLSGGQRKRVALAAALITPSELL 180 + + LT+ + + S + A Sbjct: 121 MKLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFARADEPKCGATEKQLAIFNT 180 Query: 181 ILDEPTNHIDTDSVAWLEQYLQKRRGALLMVTHDRYFLERVASVMLELDGGQLYRYEANY 240 + + + + Q + G Q + Sbjct: 181 FCEGKPGQRSIAASGGILLWPQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSS 240 Query: 241 SRFXXXXXXXXXXXXXXXXXXXNLLRTELAWIRRGAKARSTKQKARIDRFEKLKESQGPA 300 R + + G + Sbjct: 241 LIAVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGR 300 Query: 301 SAGALDISVASTRLGRKIIEMKDLTKSLDGRTLIKDLTYIAVPQDRVGIVGPNGSGKSTL 360 Sbjct: 301 360 Query: 361 LNLIAGKLQPDRGEVELGATVKLGYFTQEHQD----MDDSLRVIEYVKEEAEIIRTADGS 416 Sbjct: 361 420 Query: 417 VITAGQMLERFLFPPAMQWTPIAKLSGGEKRRLYLLRVLMGAPNVLLLDEPTNDLDIGTL 476 Sbjct: 421 480 Query: 477 AVLEDYLDEFPGVVFTVSHDRFFLDRTVDKLIAFE-NGSIRLHVGNYSEYEEWMANNIPA 535 Sbjct: 481 540 Query: 536 RGGDTPKEAGTGKNSSAPE---QGQTVPAAPPAREKL-KFTFKEQREYEG----IDEAIE 587 Sbjct: 541 ---- 596 Query: 588 QAEQHLADISAQMEAAFADSGKLQELVEKQRQGEAELERLMERWTYLNELAEKIAG 643 Sbjct: 597 ------ 646 Database: COG Posted date: Aug 3, 2010 9:58 AM Number of letters in database: 38,378,431 Number of sequences in database: 115,334 Lambda K H 0.316 0.134 0.376 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 115334 Number of Hits to DB: 47,573,071 Number of extensions: 2163483 Number of successful extensions: 25424 Number of sequences better than 1.0e-05: 1484 Number of HSP's gapped: 23104 Number of HSP's successfully gapped: 2154 Length of query: 645 Length of database: 38,378,431 Length adjustment: 113 Effective length of query: 532 Effective length of database: 25,345,689 Effective search space: 13483906548 Effective search space used: 13483906548 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 119 (50.4 bits)